CN106983904A - A kind of preparation method of iodoform gelatin sponge - Google Patents
A kind of preparation method of iodoform gelatin sponge Download PDFInfo
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- CN106983904A CN106983904A CN201710227180.0A CN201710227180A CN106983904A CN 106983904 A CN106983904 A CN 106983904A CN 201710227180 A CN201710227180 A CN 201710227180A CN 106983904 A CN106983904 A CN 106983904A
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- Prior art keywords
- iodoform
- gelatin
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- gelatin sponge
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Jellies, Jams, And Syrups (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation method of iodoform gelatin sponge, first iodoform is dissolved in ethanol, then iodoform is evenly spread in gelatin distilled water solution, behind continue to stir foaming, formaldehyde is fixed solidification etc. and prepared.Making stripping and slicing can be designed to that teeth socked wound is similarly sized and conveniently take.The iodoform gelatin sponge of finished product can be produced by being seen using this method, and good effect is reached in clinical practice.
Description
Technical field
The present invention relates to field of medical products, and in particular to a kind of preparation method of iodoform gelatin sponge.
Background technology
In the prior art, there is the sterilizing article of three kinds of main oral surgeries：1. gelfoam is in oral and maxillofacial surgery
Surgery tooth extraction and Jaw Bone Operation hemostasis with packs apply very extensive, advantage：Gelatin anastalsis very well, is can absorb.Shortcoming：Nonreactive
Infection effect.2. iodoform gauze can be used for teeth socked wound to stop blooding and alveolitis treatment, advantage：Compressive Hemostasis is definite, has
Anti-infectious function.Shortcoming：It can not degrade, need to take out.3. gelfoam+iodoform advantage：Not only it can stop blooding but also can prevent to infect,
It is widely used.Tooth extraction wound is clogged particularly after Outpatient Service Stomatology tooth extraction can stop blooding anti-infective dry socket.Shortcoming：At present
The iodoform gelatin sponge without finished product be, it is necessary to the used time can only be the iodoform skewness with picking iodoform above gelfoam on the market,
It is easy to fall off.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of preparation method of iodoform gelatin sponge, the method overcome
The shortcoming of above-mentioned prior art, produces the iodoform gelatin sponge of finished product, and good effect is reached in clinical practice.
The technical problems to be solved by the invention are achieved by the following technical programs：
A kind of preparation method of iodoform gelatin sponge, comprises the following steps：
（1）Under normal temperature, will 5-20 parts by weight iodoform add 10-15 parts by weight ethanol in, stir iodoform is molten
Liquid；
（2）In the distilled water for the 100-150 parts by weight that the gelatin of 8-15 parts by weight is added to 38 DEG C, the gelatin that bubbles to obtain is stirred
Solution；
（3）Iodoform solution and gelatin solution are pressed 1：1 ratio is mutually mixed, and adds 10-15 weight while stirring using mixer
3% formalin of number, after after its solidification, cools to -10 DEG C ~ -30 DEG C and freezes to obtain iodoform gelatin sponge；
（4）By iodoform gelatin sponge stripping and slicing, each iodoform gelatin sponge stripping and slicing of In Aluminium Foil Packing obtains finished product.
The present invention has the advantages that：
The present invention is a kind of gelfoam for carrying iodoform, can be directly used for stopping blooding and anti-infective after extraction, can also extensive utilization
In other deep wound filling operations such as Cesarean esction, it can be retrieved by human body automatic absorption without second operation.The present invention
Preparation method technological process it is succinct, it is easy to operate, production efficiency is high, according to oral cavity tooth extraction wound shape size, by iodoform gelatin
Adaptable 5mm × 5mm sizes are made in sponge, are packed into about tooth extraction wound size（ 10mm×10mm ）Lattice
Aluminium foil, it is easy to use, it is difficult pollution.Waste can be reduced simultaneously, use cost is reduced, and this method also causes iodoform gelatin sponge
Can commercialization, large-scale production processing on reach better effects.
Embodiment
With reference to embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention,
It is not limitation of the invention.
Embodiment 1
A kind of preparation method of iodoform gelatin sponge, comprises the following steps：
（1）Under normal temperature, 20 parts of parts by weight iodoform are added in 20 parts of parts by weight ethanol, stir to obtain iodoform solution；
（2）In 100 parts of parts by weight distilled water that 15 parts of parts by weight gelatin are added to 38 DEG C, the gelatin solution that bubbles to obtain is stirred；
（3）Iodoform solution and gelatin solution are pressed 1：1 ratio is mutually mixed, and adds 15 parts of weight while stirring using mixer
The formaldehyde of number 3%, after after its solidification, cools to -30 DEG C and freezes to obtain iodoform gelatin sponge；
（4）By iodoform gelatin sponge stripping and slicing, per the blockage of the block size shape 5mm × 5mm size similar with teeth socked wound
It is identical, it is convenient to clinical practice and commercialization production；
（5）With each iodoform gelatin sponge stripping and slicing of the In Aluminium Foil Packing of tooth extraction wound size 10mm × 10mm lattices, finished product is obtained.Use
In Aluminium Foil Packing, air performance is strong, anti-oxidation for barrier, waterproof, protection against the tide, mould proof；Mechanical performance is strong, and anti-burst performance is high, resists and wears
Pierce tear resistance strong；High temperature resistant（121℃）, it is low temperature resistant（-50℃）；It is nonpoisonous and tasteless, meet food, Key works Drug packing health mark
It is accurate；Heat sealability is good, flexibility, high obstructing performance are good.Doctor can be met applied to iodoform gelatin sponge of the present invention is packed
Therapeutic effect and production requirement.
Embodiment 2
A kind of preparation method of iodoform gelatin sponge, comprises the following steps：
（1）Under normal temperature, 10 parts of parts by weight iodoform are added in 10 parts of parts by weight ethanol, stir to obtain iodoform solution；
（2）In 120 parts of parts by weight distilled water that 9 parts of parts by weight gelatin are added to 38 DEG C, the gelatin solution that bubbles to obtain is stirred；
（3）Iodoform solution and gelatin solution are pressed 1：2 ratio is mutually mixed, and adds 12 parts of weight while stirring using mixer
The formaldehyde of number 3%, after after its solidification, cools to -25 DEG C and freezes to obtain iodoform gelatin sponge；
（4）By iodoform gelatin sponge stripping and slicing, per the blockage of the block size shape 5mm × 5mm size similar with teeth socked wound
It is identical, it is convenient to clinical practice and commercialization production；
（5）With each iodoform gelatin sponge stripping and slicing of the In Aluminium Foil Packing of tooth extraction wound size 10mm × 10mm lattices, finished product is obtained.Use
In Aluminium Foil Packing, air performance is strong, anti-oxidation for barrier, waterproof, protection against the tide, mould proof；Mechanical performance is strong, and anti-burst performance is high, resists and wears
Pierce tear resistance strong；High temperature resistant（121℃）, it is low temperature resistant（-50℃）；It is nonpoisonous and tasteless, meet food, Key works Drug packing health mark
It is accurate；Heat sealability is good, flexibility, high obstructing performance are good.Doctor can be met applied to iodoform gelatin sponge of the present invention is packed
Therapeutic effect and production requirement.
Embodiment 3
A kind of preparation method of iodoform gelatin sponge, comprises the following steps：
（1）Under normal temperature, 5 parts of parts by weight iodoform are added in 5 parts of parts by weight ethanol, stir to obtain iodoform solution；
（2）In 150 parts of parts by weight distilled water that 8 parts of parts by weight gelatin are added to 38 DEG C, the gelatin solution that bubbles to obtain is stirred；
（3）Iodoform solution and gelatin solution are pressed 1.5：1 ratio is mutually mixed, and adds 12 parts of weights while stirring using mixer
The formaldehyde of number 3% is measured, after after its solidification, -10 DEG C is cooled to and freezes to obtain iodoform gelatin sponge；
（4）By iodoform gelatin sponge stripping and slicing, per the blockage of the block size shape 5mm × 5mm size similar with teeth socked wound
It is identical, it is convenient to clinical practice and commercialization production；
（5）With each iodoform gelatin sponge stripping and slicing of the In Aluminium Foil Packing of tooth extraction wound size 10mm × 10mm lattices, finished product is obtained.Use
In Aluminium Foil Packing, air performance is strong, anti-oxidation for barrier, waterproof, protection against the tide, mould proof；Mechanical performance is strong, and anti-burst performance is high, resists and wears
Pierce tear resistance strong；High temperature resistant（121℃）, it is low temperature resistant（-50℃）；It is nonpoisonous and tasteless, meet food, Key works Drug packing health mark
It is accurate；Heat sealability is good, flexibility, high obstructing performance are good.Doctor can be met applied to iodoform gelatin sponge of the present invention is packed
Therapeutic effect and production requirement.
Outpatient service is selected to require to extract 1214 of backteeth totally 1293 teeth, wherein man 647,711 teeth；Female 567,
582 teeth, it is age 13-85 Sui, average 49 years old.
It is randomly divided into experimental group and control group, experimental group 620,734 teeth, control group 594,559 teeth, experimental group
Tooth extraction is after being put into iodoform gelatin sponge in alveolus（It is random to select iodoform gelatin sponge made from embodiment 1,2,3）, control
Group is then put into common gelfoam.
Case infection conditions after extraction are observed, standard is：The obvious pain of tooth extraction wound surrounding tissue or redness, or even with opening
Mouth or dysphagia, local pressure are well-illuminated aobvious, have rheuminess thing in teeth socked, laboratory leukocyte increases.
620 generation postextraction infections 13 of experimental group, incidence is 2.10%, and postextraction infection occurs for 594 control groups
33, incidence is that infection rate has statistical significance between 5.56%, two groups, it was demonstrated that iodoform gelatin sponge contrast gelatin sea
Silk floss has marked improvement at anti-infective aspect.
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
The specific implementation of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (1)
1. a kind of preparation method of iodoform gelatin sponge, comprises the following steps：
（1）Under normal temperature, will 5-20 parts by weight iodoform add 10-15 parts by weight ethanol in, stir iodoform is molten
Liquid；
（2）In the distilled water for the 100-150 parts by weight that the gelatin of 8-15 parts by weight is added to 38 DEG C, the gelatin that bubbles to obtain is stirred
Solution；
（3）Iodoform solution and gelatin solution are pressed 1 ~ 2：1 ~ 2 ratio is mutually mixed, and 10-15 is added while stirring using mixer
3% formalin of parts by weight, after after its solidification, cools to -10 DEG C ~ -30 DEG C and freezes to obtain iodoform gelatin sponge；
（4）By iodoform gelatin sponge stripping and slicing, each iodoform gelatin sponge stripping and slicing of In Aluminium Foil Packing obtains finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710227180.0A CN106983904A (en) | 2017-04-10 | 2017-04-10 | A kind of preparation method of iodoform gelatin sponge |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710227180.0A CN106983904A (en) | 2017-04-10 | 2017-04-10 | A kind of preparation method of iodoform gelatin sponge |
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| Publication Number | Publication Date |
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| CN106983904A true CN106983904A (en) | 2017-07-28 |
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| CN201710227180.0A Pending CN106983904A (en) | 2017-04-10 | 2017-04-10 | A kind of preparation method of iodoform gelatin sponge |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066812A (en) * | 2018-01-02 | 2018-05-25 | 辽宁大学 | A kind of active probiotic gelfoam and its manufacturing method |
| CN108114311A (en) * | 2017-12-20 | 2018-06-05 | 江苏省健尔康医用敷料有限公司 | The preparation method of iodoform gelatin sponge |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2121958U (en) * | 1991-06-28 | 1992-11-18 | 张泉 | Pcp-iodine gelatin sponge plaster |
| US20080138387A1 (en) * | 2006-12-07 | 2008-06-12 | Machiraju Venkat R | Hemostatic sponge and article |
-
2017
- 2017-04-10 CN CN201710227180.0A patent/CN106983904A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2121958U (en) * | 1991-06-28 | 1992-11-18 | 张泉 | Pcp-iodine gelatin sponge plaster |
| US20080138387A1 (en) * | 2006-12-07 | 2008-06-12 | Machiraju Venkat R | Hemostatic sponge and article |
Non-Patent Citations (2)
| Title |
|---|
| 杨明: "《中药药剂学》", 31 December 2008, 上海科学技术出版社 * |
| 田卫东: "《实用拔牙学》", 31 October 2003, 四川大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114311A (en) * | 2017-12-20 | 2018-06-05 | 江苏省健尔康医用敷料有限公司 | The preparation method of iodoform gelatin sponge |
| CN108066812A (en) * | 2018-01-02 | 2018-05-25 | 辽宁大学 | A kind of active probiotic gelfoam and its manufacturing method |
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Application publication date: 20170728 |
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