CN106970124B - It is a kind of based on mobile terminal for the NFC label sensing system of biochemistry detection and its application - Google Patents
It is a kind of based on mobile terminal for the NFC label sensing system of biochemistry detection and its application Download PDFInfo
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- 238000001514 detection method Methods 0.000 title claims abstract description 63
- 239000003990 capacitor Substances 0.000 claims abstract description 25
- 238000004891 communication Methods 0.000 claims abstract description 7
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 52
- 229910052697 platinum Inorganic materials 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 25
- 239000010931 gold Substances 0.000 claims description 25
- 229910052737 gold Inorganic materials 0.000 claims description 25
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 230000001580 bacterial effect Effects 0.000 claims description 12
- 230000001174 ascending effect Effects 0.000 claims description 9
- 238000013461 design Methods 0.000 claims description 8
- 241000191967 Staphylococcus aureus Species 0.000 claims description 7
- 230000005611 electricity Effects 0.000 claims description 7
- 239000002356 single layer Substances 0.000 claims description 6
- 229910021389 graphene Inorganic materials 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 230000005518 electrochemistry Effects 0.000 claims description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 239000012531 culture fluid Substances 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 abstract description 4
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 239000000758 substrate Substances 0.000 abstract description 3
- -1 NFC IC chip Substances 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 17
- 238000012360 testing method Methods 0.000 description 15
- 238000010586 diagram Methods 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 101100545272 Caenorhabditis elegans zif-1 gene Proteins 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 101100368725 Bacillus subtilis (strain 168) tagF gene Proteins 0.000 description 1
- 102100024342 Contactin-2 Human genes 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 101000731015 Homo sapiens Peptidoglycan recognition protein 1 Proteins 0.000 description 1
- 102100032393 Peptidoglycan recognition protein 1 Human genes 0.000 description 1
- 101000690440 Solanum lycopersicum Floral homeotic protein AGAMOUS Proteins 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000014670 detection of bacterium Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
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- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
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Abstract
NFC (communication of the marching into the arena) tag sensor system and its application that the invention discloses a kind of based on mobile terminal for biochemistry detection, mobile terminal of the system by NFC label sensor and with NFC function forms, NFC label sensor and mobile terminal are in communication with each other, and the NFC label sensor includes antenna, patch capacitor, NFC IC chip, PET base, slide rheostat and electrode；The antenna, patch capacitor and NFC ic chip package are on the pet substrate, one end of antenna is connected with one end of patch capacitor, the other end of patch capacitor is connected with the sliding end of slide rheostat, one end of the coil of slide rheostat is connected with one end of electrode, the other end of electrode is connected with one end of NFC IC chip, and the other end of antenna is connected with the other end of NFC IC chip.The half-quantitative detection to different target object may be implemented in the NFC label sensing system.The present invention have the characteristics that it is wireless, passive, small in size, at low cost, be convenient for carrying, can be used for the fields such as environmental monitoring, Gernral Check-up and Internet of Things.
Description
Technical field
The present invention relates to electrochemical impedance detection technique more particularly to it is a kind of based on mobile terminal for biochemistry detection
NFC label sensing system and its application.
Background technique
In recent years, smart phone is popularized in the world.Due to the powerful build-in function of smart phone, for example, it is various not
Same interface and sensor, networked capabilities, outstanding data-handling capacity, display function, so that the mobile end based on mobile phone
End plays an important role in portable sensing system.These portable sensor-based systems can be used for environmental monitoring and health chases after
The fields such as track, they are usually made of an additional sensing device and a mobile phone, and attachment device can be portable electrochemistry
Detection device, fluorescence detection device etc., mobile phone often play a control testing process, receive and handle experimental data, show
Show the function of testing result.Mobile phone and attachment device by the interfaces such as bluetooth, USB interface, camera, audio port carry out it is wired or
Wireless data transmission, attachment device obtain energy from mobile phone by interfaces such as audio ports and mention come work, or by external power supply
For energy.
It is nearest research hotspot that passive label sensor and electronics, which is tatooed, and the advantage of this novel sensor is nothing
Source, wireless, compact, flexibility can attach, and can be used for monitoring environmental contaminants and some health indicators.Their design
It is based primarily upon radio frequency identification (RFID) technology.Though this sensor has many advantages, usually require one it is bulky
Network Analyzer or impedance analyzer receive and handle experimental data, and cannot combine with some mobile terminals such as mobile phone.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide it is a kind of based on mobile terminal for biochemistry detection
NFC label sensing system and its application.
The purpose of the present invention is achieved through the following technical solutions: a kind of to be used for biochemistry detection based on mobile terminal
NFC label sensing system, mobile terminal of the system by NFC label sensor and with NFC function form, NFC label
Sensor and mobile terminal are in communication with each other, and NFC label sensor includes antenna, patch capacitor, NFC IC chip, PET base
Bottom, slide rheostat and electrode；Antenna, patch capacitor and NFC ic chip package on the pet substrate, one end of antenna
It is connected with one end of patch capacitor, the other end of patch capacitor is connected with the sliding end of slide rheostat, the line of slide rheostat
One end of circle is connected with one end of electrode, and the other end of electrode is connected with one end of NFC IC chip, the other end of antenna
It is connected with the other end of NFC IC chip.
Further, the electrode is the carbon interdigital electrode of the single-layer graphene modification through CVD growth.
Further, the electrode is made of gold electrode and platinum electrode.
It is a further object of the present invention to provide a kind of, and the NFC label for biochemistry detection based on mobile terminal senses
Application of the device system in gas concentration half-quantitative detection, includes the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat, then with the mobile terminal with NFC function close to day
Line, when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat is NFC label sensor
On-off threshold value.
(2) determination of threshold gradient distribution
The alcohol gas for configuring at least five kinds various concentrations, carbon interdigital electrode is placed in the gas chamber of constant temperature and humidity, electricity
Chem workstation is connected on two pins of electrode, the impedance variations for detecting electrode；By the alcohol gas of various concentration
It is successively passed into gas chamber, being passed through after alcohol gas every time the air of durations such as needs to be passed through, and passes through electrochemical workstation record resistance
Anti- change curve, according to impedance variations curve, design at least five at gradient distribution threshold value；
(3) half-quantitative detection of gas concentration
The alcohol gas of various concentration is successively passed into gas chamber, being passed through after alcohol gas every time the durations such as needs to be passed through
Air, and by adjusting slide rheostat by the adjusting thresholds of NFC label sensor the designed different threshold values before, pass through
Mobile terminal with NFC function reads the on-off of NFC label sensor, realizes the half-quantitative detection to gas concentration.
The present invention also provides a kind of, and the NFC label sensing system for biochemistry detection based on mobile terminal is molten in ion
Application in liquid concentration half-quantitative detection, includes the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat, then with the mobile terminal with NFC function close to day
Line, when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat is NFC label sensor
On-off threshold value.
(2) determination of threshold gradient distribution
The solion for configuring a variety of various concentrations takes isometric solion to be put into electrification every kind of concentration
It learns in pond, and gold electrode and platinum electrode is inserted into electrochemical cell, electrochemical workstation is connected on gold electrode and platinum electrode,
Record concentration-impedance curve by electrochemical workstation, according to the curve, design at least three at gradient distribution threshold value；
(3) half-quantitative detection of solion concentration
For every kind of concentration, isometric solion is taken to be put into electrochemical cell, and gold electrode and platinum electrode are inserted
Enter into electrochemical cell, by adjusting slide rheostat by the adjusting thresholds of NFC label sensor to before designed difference
Threshold value reads the on-off of NFC label sensor by the mobile terminal with NFC function, realizes half to solion concentration
Quantitative detection.
The present invention also provides a kind of, and the NFC label sensing system for biochemistry detection based on mobile terminal is dense in bacterium
The application in half-quantitative detection is spent, is included the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat, then with the mobile terminal with NFC function close to day
Line, when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat is NFC label sensor
On-off threshold value.
(2) determination of threshold gradient distribution
Inoculum is diluted to different bacterial concentrations, for every kind of concentration, isometric inoculum is taken to put
Enter into electrochemical cell, and gold electrode and platinum electrode be inserted into electrochemical cell, electrochemical workstation be connected to gold electrode and
On platinum electrode, concentration-impedance curve is recorded by electrochemical workstation, according to the curve, design at least three is at gradient distribution
Threshold value；
(3) half-quantitative detection of bacterial concentration
For every kind of concentration, isometric inoculum is taken to be put into electrochemical cell, and by gold electrode and platinum electrode
Be inserted into electrochemical cell, by adjusting slide rheostat by the adjusting thresholds of NFC label sensor to before it is designed not
Same threshold value reads the on-off of NFC label sensor by the mobile terminal with NFC function, realizes the semidefinite to bacterial concentration
Amount detection.
The present invention has the advantages that the present invention devises one kind based on movement relative to existing biochemical sensor
The NFC label sensing system for biochemistry detection of terminal is overcome by the method for slide rheostat of connecting in circuit
The shortcomings that NFC label sensor cannot carry out more accurate half-quantitative detection to object, is not only realized pair with sensor
NFC label sensor is also used for the biochemistry detection other than gas for the first time by the half-quantitative detection of alcohol gas, such as solion and
The detection of bacterium.Sensor advantages such as there is passive, wireless, inexpensive, compact, flexibility can attach itself, make simultaneously
Energy is provided for sensor with such as mobile phone of the mobile terminal with NFC function, receives and handles experimental data, and shows experiment knot
Fruit overcomes the shortcomings that existing label sensor needs the analyzing and processing datas such as the instruments such as large-scale Network Analyzer, will mark
The double dominant of label sensor and portable mobile terminal such as mobile phone is combined together.In alcohol gas sensing, NFC label sensing
The electrode section of device uses the carbon interdigital electrode of the single-layer graphene modified through CVD growth, in the inspection of solion and bacterium
In survey, traditional gold electrode and platinum electrode are used.Electrode can be replaced for different target detection things.According to above excellent
Point, the present invention can be used for the fields such as environmental monitoring, Gernral Check-up and Internet of Things.
Detailed description of the invention
Fig. 1 is the NFC label sensing system overall structure figure for biochemistry detection the present invention is based on mobile terminal；
Fig. 2 is the carbon interdigitated electrode structure figure of single-layer graphene modification of the present invention through CVD growth；
Fig. 3 is the structure chart for carrying out solution detection in the present invention using gold electrode and platinum electrode；
Fig. 4 (a) is the schematic diagram that slide rheostat is not connect in NFC label sensor, and Fig. 4 (b) is the equivalent of Fig. 4 (a)
Circuit diagram, Fig. 4 (c) are single Concentration Testing schematic diagram；
Fig. 5 (a) is to have the schematic diagram for connecing slide rheostat in NFC label sensor, and Fig. 5 (b) is the equivalent electricity of Fig. 5 (a)
Lu Tu, Fig. 5 (c) are sxemiquantitative Concentration Testing schematic diagram；
Fig. 6 is the half-quantitative detection result figure of NFC label sensing system of the invention to ethanol gas concentration；
Fig. 7 is the half-quantitative detection result figure of NFC label sensing system of the invention to KCl solion；
Fig. 8 is the half-quantitative detection result figure of NFC label sensing system of the invention to staphylococcus aureus concentration；
In figure: antenna 1, patch capacitor 2, NFC IC chip 3, PET base 4, slide rheostat 5, electrode 6, it is mobile
Terminal 7.
Specific embodiment
Below in conjunction with drawings and concrete examples, the present invention is described in detail, but is not the limitation present invention.
As shown in Figure 1, the present invention provides a kind of NFC label sensor system for biochemistry detection based on mobile terminal
System, mobile terminal 7 of the system by NFC label sensor and with NFC function form, mobile terminal such as mobile phone, and NFC label passes
Sensor and mobile terminal 7 are in communication with each other；NFC label sensor includes antenna 1, patch capacitor 2, NFC IC chip 3, PET
Substrate 4, slide rheostat 5 and electrode 6；Antenna 1, patch capacitor 2 and NFC IC chip 3 are encapsulated in PET base 4, day
One end of line 1 is connected with one end of patch capacitor 2, and the other end of patch capacitor 2 is connected with the sliding end of slide rheostat 5, sliding
One end of the coil of dynamic rheostat 5 is connected with one end of electrode 6, the other end of electrode 6 and one end of NFC IC chip 3
It is connected, the other end of antenna 1 is connected with the other end of NFC IC chip 3.
When carrying out the half-quantitative detection of gas concentration, such as alcohol gas, the electrode 6 is the single layer stone through CVD growth
The carbon interdigital electrode of black alkene modification, as shown in Fig. 2, the variation of gas concentration will lead to the variation of electrode impedance；Carrying out ion
When the half-quantitative detection of solution or bacterial concentration, such as KCl solution and staphylococcus aureus, the electrode 6 is by gold electrode and platinum
Electrode composition changes as shown in figure 3, the variation of target concentration will lead to the impedance value that electrode measures.
The building of NFC label sensor of the present invention and testing principle are as follows:
1), shown in such as Fig. 4 (a), 5 schematic diagram of slide rheostat, its equivalent circuit diagram are not connect in NFC label sensor
As shown in Fig. 4 (b), which has an on-off threshold value RThreshold value, when the resistance value of electrode 6 is lower than this threshold value, use
Mobile terminal with NFC module reads NFC label sensor, and sensor is in readable state, when the resistance value of electrode 6 is due to mesh
Mark the presence of substance and when being increased to threshold value or more, NFC label sensor be in can not read states, by being examined with mobile terminal
Survey the readable variation of NFC label sensor, so that it may detect target substance presence or absence, but since the threshold value is one
Constant value can not achieve half-quantitative detection, as shown in Fig. 4 (c) so single Concentration Testing can only be carried out to object.
2), shown in such as Fig. 5 (a), accessed 5 schematic diagram of slide rheostat in NFC label sensor, Fig. 5 (b) be it etc.
Circuit diagram is imitated, it can be seen that, the on-off threshold value of NFC label sensor originally is threshold value 1 from Fig. 5 (c), and sliding of having connected becomes
After hindering device 5, on-off threshold value has dropped RIt is sliding, become threshold value 2, i.e., the resistance value of original electrode 6 can just to pass when reaching threshold value 1
Sensor is unreadable, now when reaching threshold value 2 as long as the state of sensor can be made to change, become unreadable.For general
Object is detected, certain linear relationship can be all presented in 6 impedance of electrode with target concentration, as a result, by adjusting sliding variable resistance
The resistance value of device 5 is to a series of different values, so that it may give NFC label sensor settings a series of threshold values at gradient distribution.It is right
In some specific concentration, when sensor is under different threshold status, readability can be different, and NFC label passes under certain threshold values
Sensor is in " readable " state, and NFC label sensor is in " unreadable " state under certain threshold values, in this way with NFC module
Mobile terminal on can export a digitized testing result, correspond to various concentration or concentration range, it can realize mesh
Mark the half-quantitative detection of object.
Embodiment 1:
The half-quantitative detection of gas concentration is carried out using NFC label sensor, the electrode 6 is the single layer through CVD growth
The carbon interdigital electrode of graphene modified includes the following steps: so that alcohol gas detects as an example
(1) the on-off threshold value of NFC label sensor is measured；
It is shorted 6 both ends of electrode in NFC label sensor, the ascending resistance value for adjusting slide rheostat 5, then with having
The mobile terminal of NFC function close to antenna 1, when NFC label sensor from readable state become can not read states when, slide variable resistance
The resistance value of device 5 is the on-off threshold value of NFC label sensor, and by measurement, the on-off threshold value of the NFC label sensor is 2.7k
Ω。
(2) determination of threshold gradient distribution
Configuration concentration is respectively the alcohol gas of 5ppm, 4ppm, 3ppm, 2ppm and 1ppm.Carbon interdigital electrode is placed on
In the gas chamber of constant temperature and humidity, electrochemical workstation is connected on two pins of electrode, the impedance variations for detecting electrode；It hands over
For air and configured alcohol gas (successively reducing by concentration) is passed through, ventilate 50s every time, records carbon with electrochemical workstation
The impedance variations curve of interdigital electrode, sampling interval 1s.The impedance for obtaining electrode rises linear rise with concentration.According to ethyl alcohol
The corresponding electrode impedance change curve of gas concentration, the impedance value of slide rheostat 5 is respectively 0.1k Ω, 0.2k in adjustment circuit
Ω, 0.3k Ω, 0.4k Ω, 0.5k Ω, so that NFC label on-off threshold value is respectively 2.6k Ω, 2.5k Ω, 2.4k Ω, 2.3k Ω,
2.2k Ω, this five threshold status are denoted as TAG2, TAG3, TAG4, TAG5, TAG6 respectively.
(3) half-quantitative detection of gas concentration
The carbon interdigital electrode of NFC label sensor is partially disposed in the gas chamber of constant temperature and humidity, rest part is placed on
Outside gas chamber.The alcohol gas that air and concentration are respectively 5ppm, 4ppm, 3ppm, 2ppm and 1ppm is alternately passed into gas chamber
In, ventilate 50s every time, sampling interval 1s.For each concentration, the resistance value of slide rheostat 5 is adjusted, NFC label is sensed
The adjusting thresholds of device designed five different threshold status TAG2 to TAG6 before, with the mobile end with NFC function
The on-off that NFC label sensor is read at end is denoted as " 0 " if readable, if unreadable, is denoted as " 1 ".As shown in fig. 6, being passed through 5ppm
Alcohol gas when, the impedance value of carbon interdigital electrode is between 2.6k Ω and 2.7k Ω, more than the threshold value of all settings, so
TAG2 to TAG6 is unreadable, shows that testing result is 11111, when being passed through 4ppm alcohol gas on mobile terminal, the interdigital electricity of carbon
The impedance value of pole is between 2.5k Ω and 2.6k Ω, on-off threshold value lower than TAG2, is higher than other threshold values, so mobile terminal
Upper display testing result is 01111, and so on, the testing result that 3ppm, 2ppm and 1ppm are obtained is respectively 00111,00011
It, should be the result shows that NFC label sensor can be used for the half-quantitative detection of alcohol gas with 00001.
Embodiment 2:
The half-quantitative detection of solion concentration is carried out using NFC label sensor, the electrode 6 is by gold electrode and platinum electricity
Pole composition, by taking the detection of KCl solution as an example, includes the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
It is shorted 6 both ends of electrode in NFC label sensor, the ascending resistance value for adjusting slide rheostat 5, then with having
The mobile terminal of NFC function close to antenna 1, when NFC label sensor from readable state become can not read states when, slide variable resistance
The resistance value of device 5 is the on-off threshold value of NFC label sensor, and by measurement, the on-off threshold value of the NFC label sensor is 2.7k
Ω。
(2) determination of threshold gradient distribution
Configure the KCl solution of 18 various concentrations, concentration gradient 0.008M, 0.009M, 0.01M, 0.011M,
0.012M,0.013M,0.014M,0.015M,0.016M,0.02M,0.03M,0.04M,0.05M,0.06M,0.07M,0.08M,
0.09M, and 0.1M take 4mL to be put into electrochemical cell each concentration, and gold electrode and platinum electrode are extend into solution,
Electrochemical workstation is connected on gold electrode and platinum electrode, surveys the impedance value under various concentration, draws concentration-impedance curve.It is double
The impedance that electrode measures is reduced with the raising of KCl concentration, according to the curve, the resistance value of slide rheostat 5 is adjusted, to set
Three different on-off threshold value 2.7k Ω, 1.35k Ω and 0.45k Ω are counted, are denoted as TAG1, TAG7 and TAG8 respectively.
(3) half-quantitative detection of solion concentration
For the KCl solution of each concentration, 4mL is taken to be put into electrochemical cell, gold electrode and platinum electrode are extend into solution
In.By the adjusting thresholds of NFC label sensor to the three different threshold values set, with the mobile terminal with NFC function
The on-off for reading NFC label sensor is denoted as " 0 " if readable, if unreadable, is denoted as " 1 ".As shown in fig. 7, working as the concentration of KCl
When more than or equal to 0.05M, the impedance that electrode measures is lower than all on-off threshold values, so the detection knot shown on mobile terminal
Fruit is 000, and when the concentration of KCl is more than or equal to 0.02M and is less than or equal to 0.05M, electrode impedance is more than the threshold value of TAG8, TAG8
Become unreadable, testing result 001, and so on, when concentration is between 0.01M to 0.016M, testing result 011 is dense
When degree is less than or equal to 0.009M, testing result 111.This is the result shows that NFC label sensor may be implemented to solion
Half-quantitative detection.
Embodiment 3:
The half-quantitative detection of bacterial concentration is carried out using NFC label sensor, the electrode 6 is by gold electrode and platinum electrode group
At including the following steps: by taking the detection of staphylococcus aureus as an example
(1) the on-off threshold value of NFC label sensor is measured；
It is shorted 6 both ends of electrode in NFC label sensor, the ascending resistance value for adjusting slide rheostat 5, then with having
The mobile terminal of NFC function close to antenna 1, when NFC label sensor from readable state become can not read states when, slide variable resistance
The resistance value of device 5 is the on-off threshold value of NFC label sensor, and by measurement, the on-off threshold value of the NFC label sensor is 2.7k
Ω。
(2) determination of threshold gradient distribution
The staphylococcus aureus culture solution of 2 kinds of various concentrations is configured, concentration is respectively 105(c)FU/mL and 106CFU/mL,
And as a control group with empty culture solution, three groups take 4mL in electrochemical cell respectively, and gold electrode and platinum electrode are extend into solution
In, electrochemical workstation is connected on gold electrode and platinum electrode, surveys the impedance value under various concentration, draws concentration-impedance curve.
According to the curve, the resistance value of slide rheostat 5 is adjusted, thus two different on-off threshold value 0.3k Ω and 0.25k Ω of design, point
TAG9 and TAG10 are not denoted as it.
(3) half-quantitative detection of bacterial concentration
The staphylococcus aureus culture solution of 2 kinds of various concentrations is configured, concentration is respectively 105 (c) FU/mL and 106CFU/
ML, and as a control group with empty culture solution, three groups take 4mL in electrochemical cell respectively, and gold electrode and platinum electrode are extend into
In solution, it is denoted as " 0 " if readable with the on-off that the mobile terminal with NFC function reads NFC label sensor, if can not
It reads, is denoted as " 1 ".As shown in figure 8, when the concentration of bacterium is 106When CFU/mL, impedance value that electrode measures be higher than TAG9 and
The on-off threshold value of TAG10, so the testing result shown on mobile terminal is 11, bacterial concentration 105(c)When FU/mL, detection
It as a result is 01, when bacterial concentration is 0, testing result 00.The result shows that bacterium also may be implemented with NFC label sensor
The half-quantitative detection of concentration.
Claims (3)
1. a kind of NFC label sensing system for biochemistry detection based on mobile terminal is in gas concentration half-quantitative detection
Application, the NFC label sensing system for biochemistry detection based on mobile terminal by NFC label sensor and has
The mobile terminal (7) of NFC function forms, and NFC label sensor and mobile terminal (7) are in communication with each other, the NFC label sensor
Including antenna (1), patch capacitor (2), NFC IC chip (3), PET base (4), slide rheostat (5) and electrode (6)；
The antenna (1), patch capacitor (2) and NFC IC chip (3) are encapsulated on PET base (4), one end of antenna (1) with
One end of patch capacitor (2) is connected, and the other end of patch capacitor (2) is connected with the sliding end of slide rheostat (5), slides variable resistance
One end of the coil of device (5) is connected with one end of electrode (6), and the one of the other end of electrode (6) and NFC IC chip (3)
End is connected, and the other end of antenna (1) is connected with the other end of NFC IC chip (3), and the electrode (6) is through chemical gas
The mutually carbon interdigital electrode of the single-layer graphene modification of deposition CVD growth；It is characterized by comprising the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat (5), then with the mobile terminal with NFC function close to day
Line (1), when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat (5) is NFC label
The on-off threshold value of sensor；
(2) determination of threshold gradient distribution
The alcohol gas for configuring at least five kinds various concentrations, carbon interdigital electrode is placed in the gas chamber of constant temperature and humidity, electrochemistry
Work station is connected on two pins of electrode, the impedance variations for detecting electrode；Successively by the alcohol gas of various concentration
It is passed into gas chamber, being passed through after alcohol gas every time the air of durations such as needs to be passed through, and passes through electrochemical workstation and records impedance and becomes
Change curve, according to impedance variations curve, design at least five at gradient distribution threshold value；
(3) half-quantitative detection of gas concentration
The alcohol gas of various concentration is successively passed into gas chamber, being passed through after alcohol gas every time the sky of durations such as needs to be passed through
Gas, and by the adjusting thresholds of NFC label sensor, the designed various concentration institute before is right by adjusting slide rheostat (5)
The threshold value answered reads the on-off of NFC label sensor by the mobile terminal with NFC function, realizes half to gas concentration
Quantitative detection.
2. a kind of NFC label sensing system for biochemistry detection based on mobile terminal is examined in solion concentration sxemiquantitative
Application in survey, the NFC label sensing system for biochemistry detection based on mobile terminal by NFC label sensor and
Mobile terminal (7) composition with NFC function, NFC label sensor and mobile terminal (7) are in communication with each other, and the NFC label passes
Sensor includes antenna (1), patch capacitor (2), NFC IC chip (3), PET base (4), slide rheostat (5) and electrode
(6)；The antenna (1), patch capacitor (2) and NFC IC chip (3) are encapsulated on PET base (4), and the one of antenna (1)
End is connected with one end of patch capacitor (2), and the other end of patch capacitor (2) is connected with the sliding end of slide rheostat (5), sliding
One end of the coil of rheostat (5) is connected with one end of electrode (6), the other end of electrode (6) and NFC IC chip (3)
One end be connected, the other end of antenna (1) is connected with the other end of NFC IC chip (3), electrode (6) You Jin electricity
Pole and platinum electrode composition；It is characterized by comprising the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat (5), then with the mobile terminal with NFC function close to day
Line (1), when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat (5) is NFC label
The on-off threshold value of sensor；
(2) determination of threshold gradient distribution
The KCL solution for configuring a variety of various concentrations takes isometric KCL solution to be put into electrochemical cell every kind of concentration,
And gold electrode and platinum electrode are inserted into electrochemical cell, electrochemical workstation is connected on gold electrode and platinum electrode, passes through electricity
Chem workstation records concentration-impedance curve, according to the curve, design at least three at gradient distribution threshold value；
(3) half-quantitative detection of KCL solution concentration
For every kind of concentration, isometric KCL solution is taken to be put into electrochemical cell, and gold electrode and platinum electrode are inserted into electricity
In chemical bath, by adjusting slide rheostat (5) by the adjusting thresholds of NFC label sensor to before designed various concentration
Corresponding threshold value reads the on-off of NFC label sensor by the mobile terminal with NFC function, realizes dense to KCL solution
The half-quantitative detection of degree.
3. a kind of NFC label sensing system for biochemistry detection based on mobile terminal is in bacterial concentration half-quantitative detection
Application, the NFC label sensing system for biochemistry detection based on mobile terminal by NFC label sensor and has
The mobile terminal (7) of NFC function forms, and NFC label sensor and mobile terminal (7) are in communication with each other, the NFC label sensor
Including antenna (1), patch capacitor (2), NFC IC chip (3), PET base (4), slide rheostat (5) and electrode (6)；
The antenna (1), patch capacitor (2) and NFC IC chip (3) are encapsulated on PET base (4), one end of antenna (1) with
One end of patch capacitor (2) is connected, and the other end of patch capacitor (2) is connected with the sliding end of slide rheostat (5), slides variable resistance
One end of the coil of device (5) is connected with one end of electrode (6), and the one of the other end of electrode (6) and NFC IC chip (3)
End be connected, the other end of antenna (1) is connected with the other end of NFC IC chip (3), the electrode (6) by gold electrode with
Platinum electrode composition；It is characterized by comprising the following steps:
(1) the on-off threshold value of NFC label sensor is measured；
Short circuit electrode, the ascending resistance value for adjusting slide rheostat (5), then with the mobile terminal with NFC function close to day
Line (1), when NFC label sensor from readable state become can not read states when, the resistance value of slide rheostat (5) is NFC label
The on-off threshold value of sensor；
(2) determination of threshold gradient distribution
Staphylococcus aureus culture solution is diluted to different bacterial concentrations, for every kind of concentration, takes isometric golden yellow
Staphylococcus culture fluid is put into electrochemical cell, and gold electrode and platinum electrode are inserted into electrochemical cell, electrochemical operation
Station is connected on gold electrode and platinum electrode, records concentration-impedance curve by electrochemical workstation, and according to the curve, design is extremely
Few three threshold values at gradient distribution；
(3) half-quantitative detection of bacterial concentration
For every kind of concentration, isometric staphylococcus aureus culture solution is taken to be put into electrochemical cell, and by gold electrode and
Platinum electrode is inserted into electrochemical cell, sets the adjusting thresholds of NFC label sensor before by adjusting slide rheostat (5)
Threshold value corresponding to the various concentration counted reads the on-off of NFC label sensor by the mobile terminal with NFC function,
Realize the half-quantitative detection to bacterial concentration.
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