CN106969813A - A kind of high-precision pipettor automatic calibrator - Google Patents
A kind of high-precision pipettor automatic calibrator Download PDFInfo
- Publication number
- CN106969813A CN106969813A CN201710258025.5A CN201710258025A CN106969813A CN 106969813 A CN106969813 A CN 106969813A CN 201710258025 A CN201710258025 A CN 201710258025A CN 106969813 A CN106969813 A CN 106969813A
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- China
- Prior art keywords
- pipettor
- suction nozzle
- liquid
- feed screw
- precision
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- 239000007788 liquid Substances 0.000 claims abstract description 66
- 238000005303 weighing Methods 0.000 claims abstract description 29
- 238000004458 analytical method Methods 0.000 claims abstract description 21
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000009434 installation Methods 0.000 claims abstract description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 238000009834 vaporization Methods 0.000 claims description 6
- 230000008016 vaporization Effects 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims 1
- 238000012795 verification Methods 0.000 abstract description 7
- 238000013461 design Methods 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000010876 biochemical test Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F25/00—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
- G01F25/0084—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume for measuring volume
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- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of high-precision pipettor automatic calibrator, including pipettor moving parts, liquid weighing component, suction nozzle storage assembly for storing and device pedestal.Pipettor moving parts include down-feed screw and horizontal lead screw, and the top of down-feed screw is connected with motor vertical, and the side of horizontal lead screw is connected with the sliding block also set up on horizontal motor, down-feed screw for installing pipettor to be measured；Liquid weighing component includes being provided with liquid container on high accuracy analysis balance, high accuracy analysis balance；Suction nozzle storage assembly for storing includes the suction nozzle box support for being used to deposit disposable liquid-transfering sucker.The device possesses the pipettor moving parts of horizontal and vertical two dimensional motion ability by design, liquid weighing component and suction nozzle charging assembly are combined can realize the pipettor calibrating installation of automation in the same apparatus, improve calibrating efficiency, reduce gauging error, expand calibrating scope so that pipettor verification result has more confidence level.
Description
Technical field
The present invention relates to pipettor Calibration Technology, and in particular to a kind of high-precision pipettor automatic calibrator is used to examine and determine
Whether pipettor to be measured meets concerned countries (world) standard.
Background technology
In biochemical test and clinical detection, pipettor is one of core devices of whole experiment flow, the shifting of pipettor
Liquid precision directly influences the whole result tested and detected.Underproof liquid relief precision can not only increase experimental error, in height
The failure of an experiment is resulted even in the biochemical test of required precision.The either shifting of commercial pipettor or laboratory internal design
Liquid device engineering machine, it is all very necessary operation to detect whether its liquid relief precision meets concerned countries (world) standard.It is existing
Pipettor automatic calibrator is a fixed platform, does not possess horizontal and vertical two dimensional motion ability, not by liquid
Weigh assembly and suction nozzle charging assembly are integrated in same system, therefore generally require in verification process that suction nozzle first to be loaded into mould
Block, which is placed on platform, loads suction nozzle, removes suction nozzle load-on module after the completion of suction nozzle loading, then liquid weighing module is put manually
Put on platform, and the automatic pipettor for possessing vertical motion capabilities can only be examined and determine, calibrating scope is small.For there are a large amount of weights
The verifying process flow of renaturation manipulation, this will extremely expend time and manpower, and may introduce human error, and it is accurate that influence is examined and determine
Degree.
The content of the invention
Goal of the invention：The problem of existing for prior art, the present invention provides a kind of high-precision pipettor automatic Verification dress
Put.The device possesses the pipettor moving parts of horizontal and vertical two dimensional motion ability by design, by liquid weighing component and
Suction nozzle charging assembly is combined can realize the pipettor calibrating installation of automation in the same apparatus, improve calibrating efficiency, reduction inspection
Determine error, expand calibrating scope so that pipettor verification result has more confidence level.
Technical scheme：To achieve these goals, a kind of high-precision pipettor automatic calibrator as described in the present invention,
It is characterised in that it includes pipettor moving parts, liquid weighing component, suction nozzle storage assembly for storing and device pedestal；The liquid claims
Restructuring part, suction nozzle storage assembly for storing are mounted side by side on device pedestal, and pipettor moving parts are arranged on liquid weighing component and suction
Head storage assembly for storing rear；The pipettor moving parts include down-feed screw and horizontal lead screw, and the top of down-feed screw is connected with
Motor vertical, the side of horizontal lead screw is connected with the cunning also set up on horizontal motor, down-feed screw for installing pipettor to be measured
Block；The liquid weighing component includes being provided with liquid container on high accuracy analysis balance, high accuracy analysis balance；The suction nozzle
Storage assembly for storing includes the suction nozzle box support for being used to deposit disposable liquid-transfering sucker.
Pipettor moving parts are used to fix and drive pipettor to be measured to move, wherein above and below motor vertical driving pipettor
Motion, horizontal motor driving pipettor horizontal movement.
Liquid weighing component is used for carrying out high-precision weighing to test liquid and recording result, wherein high accuracy analysis day
Flat that prepare liquid is weighed, liquid container is used to hold testing liquid.
Suction nozzle storage assembly for storing is used to deposit the disposable tip used in liquid relief.
In the pipettor moving parts, with independent vertical movement module and horizontal movement module so that this is high-precision
Degree pipettor automatic calibrator possesses two dimensional motion ability, and independent liquid weighing component and suction nozzle storage assembly for storing are combined
In same device, the automatic flow of pipettor calibrating is realized.
Further, the down-feed screw side is provided with upper limit level sensor and lower limit level sensor.Upper limit is sensed
Device and lower limit level sensor are used to limit pipettor up and down motion scope.
Further, liquid container top is provided with vaporization prevention trap.Vaporization prevention trap is used to prevent liquid evaporation.
Further, fixation kit is additionally provided with the pipettor moving parts, fixation kit one end is fixed on high-precision
Spend on assay balance, the other end is fixed on device pedestal.Fixation kit is used to prevent high accuracy analysis balance to examine in pipettor
Situation is moved during fixed, weighing operation is influenceed.The fixation kit is Z-shaped brandreth, fixed high respectively by screw
The gentle device pedestal of precision analysis day.
Further, the suction nozzle box frame bottom is provided with suction nozzle box locating piece.Locating piece is used to determine each liquid relief
The putting position of suction nozzle box support when device calibrating starts.
Further, described four screws of pipettor to be measured are fixed on the sliding block of down-feed screw, the sliding block and vertical
Leading screw is engaged by screw thread.
Operation principle：Step 1：Pipettor to be measured is held within down-feed screw by the present apparatus by four screws first
Sliding block on, sliding block and down-feed screw are engaged by screw thread, when motor vertical driving down-feed screw rotation when just can drive simultaneously
Movable slider moves up and down, so that the pipettor to be measured for promoting to be fixed on sliding block possesses the ability moved in vertical direction, its
Middle upper limit level sensor is used for the upper limit of movement for limiting pipettor to be measured, and lower limit level sensor is used for the fortune for limiting pipettor to be measured
Dynamic lower limit
Step 2：After pipettor installation to be measured, it is to be measured to make that the present apparatus drives horizontal screw lead to rotate by horizontal motor
Fixed position above pipettor horizontal movement, pipettor to be measured horizontal movement first to suction nozzle box support, is then transported vertically downward
Dynamic, until pipettor to be measured successfully loads the disposable liquid-transfering sucker being stored on suction nozzle box support, wherein locating piece is used for true
The putting position of suction nozzle box support when fixed each pipettor calibrating starts；
Step 3：After the completion of disposable liquid-transfering sucker loading, the present apparatus drives pipettor horizontal movement to be measured to high accuracy point
Fixed position above balance is analysed, then pipettor vertical downward movement to be measured so that disposable liquid-transfering sucker, which enters, fills test
In the liquid container of liquid and test liquid is drawn, after the completion of absorption, pipettor upward vertical movement to be measured to initial position is high
Precision analysis balance carries out peeling operation, after the completion of peeling operation, pipettor to be measured again vertical downward movement to liquid container
Middle release test liquid, and motion comes back to initial position upwards, high accuracy analysis balance then enters to the test liquid of release
Row weighing operation simultaneously records test liquid weight, and wherein vaporization prevention trap is used to prevent the test liquid Influence of Evaporation in liquid container
Weigh, fixation kit is used to prevent high accuracy analysis balance from moving situation in pipettor verification process, influences the behaviour that weighs
Make.
Step 4：Pipettor horizontal movement to be measured unloads disposable liquid-transfering sucker to specified location.
Step 1-4 weighs flow for once complete liquid relief, and repeat step 2-4 can obtain multigroup liquid relief weighing data,
And statistical analysis is carried out, the liquid relief precision of pipettor (2) to be measured is calculated, examines and determine whether it meets concerned countries (world) mark
It is accurate.
Beneficial effect：Compared with prior art, the invention has the advantages that：
Being applied in combination by pipettor moving parts, liquid weighing component and suction nozzle storage assembly for storing of the invention, by liquid relief
Pipetting and weighing operation in device verifying process flow are combined in same device, realize the automation stream of pipettor calibrating
Journey.The horizontal movement ability that device possesses allows liquid weighing component and suction nozzle storage assembly for storing to be combined while being placed on device
Use, improve the automaticity of device；The vertical motion capabilities possessed are not so that itself possesses treating for up and down motion ability
The automatic Verification of pipettor can also be realized in the automation equipment of design by surveying pipettor, expand the calibrating scope of pipettor,
Improve the detection capability of device.
Brief description of the drawings
Fig. 1 is a kind of structural representation of high-precision pipettor automatic calibrator of the present invention；
Fig. 2 is a kind of front view of high-precision pipettor automatic calibrator of the present invention；
Fig. 3 is Fig. 2 left view；
Fig. 4 is Fig. 2 top view.
Embodiment
The present invention will be further described with accompanying drawing with reference to embodiments.
Embodiment
As Figure 1-4, a kind of high-precision pipettor automatic calibrator, including pipettor moving parts 1, liquid weighing
Component 2, suction nozzle storage assembly for storing 3 and device pedestal 4；Liquid weighing component 2, suction nozzle storage assembly for storing 3 are mounted side by side on device pedestal 4
On, pipettor moving parts 1 are arranged on liquid weighing component 2 and the rear of suction nozzle storage assembly for storing 3.
Pipettor moving parts 1 include down-feed screw 5 and horizontal lead screw 6, and the top of down-feed screw 5 is connected with motor vertical
7, the side of horizontal lead screw 6 is connected with the sliding block also set up on horizontal motor 8, down-feed screw 5 for installing pipettor 9 to be measured
10, pipettor 9 to be measured is fixed on 10 on the sliding block of down-feed screw 5 by four screws, and sliding block 10 and down-feed screw 5 pass through screw thread
Engagement, the side of down-feed screw 5 is provided with upper limit level sensor 15-1 and lower limit level sensor 15-2.
Liquid weighing component 2 includes being provided with liquid container 12 on high accuracy analysis balance 11, high accuracy analysis balance 11,
The top of liquid container 12 is provided with vaporization prevention trap 16.By setting fixation kit 17 to prevent balance on pipettor moving parts 2
Move, fixation kit 17 is that Z-shaped brandreth is fixed on high accuracy analysis balance 11 by screw one end, and the other end is fixed on
On device pedestal 4.
Suction nozzle storage assembly for storing 3 includes the suction nozzle box support 14 for being used to deposit disposable liquid-transfering sucker 13, suction nozzle box support 14
Bottom is provided with suction nozzle box locating piece 18.
Pipettor 9 to be measured is held within the sliding block 10 of down-feed screw 5 by the present apparatus by four screws first, sliding
Block 10 and down-feed screw 5 are engaged by screw thread, and sliding block just can be driven simultaneously when the driving down-feed screw 5 of motor vertical 7 rotates
10 move up and down, so that the pipettor to be measured 9 for promoting to be fixed on sliding block 19 possesses the ability moved in vertical direction, wherein
Upper limit level sensor 15-1 is used for the upper limit of movement for limiting pipettor to be measured, and lower limit level sensor 15-2 is used to limit liquid relief to be measured
The motion lower limit of device
After the installation of pipettor 9 to be measured, the present apparatus drives horizontal screw lead rotation to make liquid relief to be measured by horizontal motor 8
Then the horizontal movement of device 9, pipettor 9 to be measured horizontal movement first transports vertically downward to the top fixed position of suction nozzle box support 14
Dynamic, until pipettor 9 to be measured successfully loads the disposable liquid-transfering sucker 13 being stored on suction nozzle box support 14, wherein suction nozzle box are determined
Position block 18 is used for the putting position for determining suction nozzle box support 14 when each pipettor calibrating starts；
After the completion of disposable liquid-transfering sucker 13 is loaded, the present apparatus drives the horizontal movement of pipettor 9 to be measured to high accuracy analysis
The top fixed position of balance 11, the then vertical downward movement of pipettor 9 to be measured so that disposable liquid-transfering sucker 13, which enters, fills survey
In the liquid container 12 of test solution body and test liquid is drawn, after the completion of absorption, the upward vertical movement of pipettor 9 to be measured to initial bit
Put, high accuracy analysis balance 11 carries out peeling operation, after the completion of peeling operation, and vertical downward movement is extremely again for pipettor 9 to be measured
Test liquid is discharged in liquid container 12, and motion comes back to initial position upwards, high accuracy analysis balance 11 is then to release
Test liquid carry out weighing operation and record test liquid weight, wherein vaporization prevention trap 16 is used to prevent the survey in liquid container
The influence of test solution evacuator body is weighed, and fixation kit 17 is used to prevent high accuracy analysis balance from moving in pipettor verification process
Situation, influences weighing operation.
The horizontal movement of pipettor 9 to be measured unloads disposable liquid-transfering sucker 13 to calibrating installation low order end, completes once complete
Liquid relief weigh flow.Multigroup liquid relief weighing data can be obtained by repeating above-mentioned Overall Steps, and carry out statistical analysis, be calculated
The liquid relief precision of pipettor 9 to be measured, examines and determine whether it meets concerned countries (world) standard, i.e. JJG 646-2006 pipettors calibrating
Code and ISO 8655International Standard.
Claims (8)
1. a kind of high-precision pipettor automatic calibrator, it is characterised in that including pipettor moving parts (1), liquid weighing
Component (2), suction nozzle storage assembly for storing (3) and device pedestal (4)；The liquid weighing component (1), suction nozzle storage assembly for storing (3) are side by side
On device pedestal (4), pipettor moving parts (1) are arranged on after liquid weighing component (2) and suction nozzle storage assembly for storing (3)
Side；The pipettor moving parts (1) include down-feed screw (5) and horizontal lead screw (6), and the top of down-feed screw (5) is connected with
Motor vertical (7), the side of horizontal lead screw (6) is connected with to also set up on horizontal motor (8), down-feed screw (5) and treated for installation
Survey the sliding block (10) of pipettor (9)；The liquid weighing component (2) includes high accuracy analysis balance (11), high accuracy analysis day
Liquid container (12) is provided with flat (11)；The suction nozzle storage assembly for storing (3) includes being used to deposit disposable liquid-transfering sucker (13)
Suction nozzle box support (14).
2. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the down-feed screw (5)
Side is provided with upper limit level sensor (15-1) and lower limit level sensor (15-2).
3. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the liquid container (12)
Top is provided with vaporization prevention trap (16).
4. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the liquid weighing component
(2) fixation kit (17) is additionally provided with, fixation kit (17) one end is fixed on high accuracy analysis balance (11), and the other end is solid
It is scheduled on device pedestal (4).
5. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the fixation kit (17)
For Z-shaped brandreth, high accuracy analysis balance (11) and device pedestal (4) are fixed by screw respectively.
6. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the suction nozzle box support
(14) bottom is provided with suction nozzle box locating piece (18).
7. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the pipettor to be measured
(9) four screws are fixed on the sliding block of down-feed screw (5) (10).
8. high-precision pipettor automatic calibrator according to claim 1, it is characterised in that the sliding block (10) and hang down
Raw silk rings thick stick (5) is engaged by screw thread.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710258025.5A CN106969813B (en) | 2017-04-19 | 2017-04-19 | Automatic calibrating device of high-precision pipettor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710258025.5A CN106969813B (en) | 2017-04-19 | 2017-04-19 | Automatic calibrating device of high-precision pipettor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106969813A true CN106969813A (en) | 2017-07-21 |
| CN106969813B CN106969813B (en) | 2024-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710258025.5A Active CN106969813B (en) | 2017-04-19 | 2017-04-19 | Automatic calibrating device of high-precision pipettor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333077A (en) * | 2018-02-08 | 2018-07-27 | 北京市临床检验中心 | A method of measuring fluid density |
| CN113856782A (en) * | 2021-11-05 | 2021-12-31 | 常州市聚光宇业机电有限公司 | Multi-channel variable-pitch liquid transfer module |
| WO2022001084A1 (en) * | 2020-06-29 | 2022-01-06 | 上海思路迪生物医学科技有限公司 | Three-degree-of-freedom library preparation cartridge and method |
| CN114279978A (en) * | 2021-12-29 | 2022-04-05 | 南京祥中生物科技有限公司 | Novel full-automatic detection and analysis workstation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333077A (en) * | 2018-02-08 | 2018-07-27 | 北京市临床检验中心 | A method of measuring fluid density |
| WO2022001084A1 (en) * | 2020-06-29 | 2022-01-06 | 上海思路迪生物医学科技有限公司 | Three-degree-of-freedom library preparation cartridge and method |
| EP4174225A4 (en) * | 2020-06-29 | 2024-07-10 | 3D Biomedicine Science & Tech Co Limited | Three-degree-of-freedom library preparation cartridge and method |
| CN113856782A (en) * | 2021-11-05 | 2021-12-31 | 常州市聚光宇业机电有限公司 | Multi-channel variable-pitch liquid transfer module |
| CN114279978A (en) * | 2021-12-29 | 2022-04-05 | 南京祥中生物科技有限公司 | Novel full-automatic detection and analysis workstation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106969813B (en) | 2024-01-23 |
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