CN106963826A - 一种活络膏配方及其膏剂制备方法 - Google Patents

一种活络膏配方及其膏剂制备方法 Download PDF

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CN106963826A
CN106963826A CN201710269554.5A CN201710269554A CN106963826A CN 106963826 A CN106963826 A CN 106963826A CN 201710269554 A CN201710269554 A CN 201710269554A CN 106963826 A CN106963826 A CN 106963826A
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王文惠
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Beijing Boaz Biological Science And Technology Co Ltd
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Abstract

本发明涉及一种活络膏配方及其膏剂制备方法，其关键技术点在于，其由如下活性组分组成：菊花80‑120份，密蒙花80‑120份份，柴胡50‑70份，蒺藜65‑95份，蝉蜕50‑70份，红花50‑70份，薄荷65‑95份，决明子65‑95份，丹参32‑48份，赤芍32‑48份，木贼50‑70份，黄芪50‑70份，黄连50‑70份，冰片6‑14份，川芎65‑95份，本发明所提供的膏剂直接涂抹到人体上的经络穴位，无任何毒副作用，只外敷，不涉及内服，不会危及到人体健康，通过疏通肝胆经络，增强人体肝胆的排毒功能，从而保证眼睛的微量元素的供给，对视力亚健康起到良好的调理效果，同时还可以增强人体对食物中营养的吸收效果，从而增加人体免疫力。

Description

一种活络膏配方及其膏剂制备方法
技术领域
本发明涉及一种活络膏配方及其膏剂制备方法，涉及中药领域。
背景技术
目前，随着工作学习生活压力的普遍增加，紧张的节奏给人们的情绪和健康带来了不良影响，例如失眠，目赤，视疲劳，容食欲不振，舌苔变白等等，从中医角度解释为肝胆经络不通所致。中医认为，“肝主目”是肝的生理功能，这个功能的实现通过肝的疏泄来完成，从经络分布上看，有十五条经络均分布眼睛的各个部位，多角度的为眼睛提供气血，其中胆经是分布眼睛的重要经络。而现有的治疗方法多为口服药物，例如CN200510012929.7公开的治疗肝胆病的药物胶囊及其制备方法，其具有通胆肝经络，清肝解毒，利胆清热，疏肝理气，抗菌消炎，解痉排石的功效，而中所周知的，长期服用药物会对身体产生不利影响。
发明内容
本发明所要解决的技术问题是提供一种可以有效治疗视力亚健康并促进营养吸收的活络膏配方，并同时提供其膏剂的制备方法。
为解决上述问题，本发明所采取的技术方案是：
本发明一方面提供了一种活络膏配方，其关键技术点在于，其由如下活性组分组成：菊花80-120份，密蒙花80-120份份，柴胡50-70份，蒺藜65-95份，蝉蜕50-70份，红花50-70份，薄荷65-95份，决明子65-95份，丹参32-48份，赤芍32-48份，木贼50-70份，黄芪50-70份，黄连50-70份，冰片6-14份，川芎65-95份。
进一步的其由如下活性组分组成：菊花100份，密蒙花100份，柴胡60份，蒺藜80份，蝉蜕60份，红花60份，薄荷80份，决明子80份，丹参40份，赤芍40份，木贼60份，黄芪60份，黄连60份，冰片10份，川芎80份。
进一步的还包括如下辅料：硬脂酸200-400份，凡士林40-60份，甘油40-60份，三乙醇胺22-27份。
本发明另一方面提供了一种上述膏剂的制备方法，具体步骤如下：
1)按重量份称取活性组分药材粉碎成颗粒放入砂锅内，加入以上药材6-10倍重量的水，武火至沸腾，转文火熬1.5小时，过滤将药液倒出，药渣中再次加入初次加入药材3-5倍重量的水，武火至沸腾，转文火熬1小时，过滤将药液倒出；
2)将二次熬制的药液一起再次熬制，得到浓缩液；
3)将浓缩液温度降至60-80℃度，加入硬脂酸，凡士林和甘油，搅拌至全部溶解；
4) 加入三乙醇胺乳化成膏，冷却后即得。
作为本发明进一步的改进，所述浓缩液的重量为初次加入活性组分药材重量的2-3倍。
在本发明中，各中药材的功效如下：
菊花为菊科植物菊Chrysanthemum morifolium Ramat.的干燥头状花序。性味：甘、苦，微寒。归经：归肺、肝经。功能主治：散风清热，平肝明目。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花。
密蒙花为马钱科植物密蒙花Buddleja officinalis Maxim.的干燥花蕾及其花序。性味甘，微寒。归经归肝经。功能主治清热养肝，明目退翳。用于目赤肿痛，多泪羞明，眼生翳膜，肝虚目暗，视物昏花。
柴胡为伞形科植物柴胡Bupleurum chinense DC.或狭叶柴胡Bupleurumscorzonerifolium Willd.的干燥根。性味：苦，微寒。归经：归肝、胆经。功能主治：和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。
蒺藜为蒺藜科植物蒺藜Tribulus terrestris L. 的干燥成熟果实。性味辛、苦，微温；有小毒。归经归肝经。功能主治平肝解郁，活血祛风，明目，止痒。用于头痛眩晕，胸胁胀痛，乳闭乳痈，目赤翳障，风疹瘙痒。
蝉蜕为蝉科昆虫黑蚱Cryptotympana pustulata Fabricius的幼虫羽化时脱落的皮壳。性味甘，寒。归经归肺、肝经。功能主治散风除热，利咽，透疹，退翳，解痉。用于风热感冒，咽痛，音哑，麻疹不透，风疹瘙痒，目赤翳障，惊风抽搐，破伤风。
红花为菊科植物红花Carthamus tinctorius L.的干燥花。性味辛，温。归经归心、肝经。功能主治活血通经，散瘀止痛。用于经闭，痛经，恶露不行，症瘕痞块，跌扑损伤，疮疡肿痛。
薄荷为唇形科薄荷属植物薄荷 Mentha haplocalyx Briq.的干燥地上部分。性味辛，凉。归经归肺、肝经。功能主治宣散风热。清头目，透疹。用于风热感冒，风温初起，头痛，目赤，喉痹，口疮，风疹，麻疹，胸胁胀闷。
决明子为豆科植物决明Cassia obtusifolia L. 或小决明Cassia tora L. 的干燥成熟种子。性味甘、苦、咸，微寒。归经归肝、大肠经。功能主治清热明目，润肠通便。用于目赤涩痛，羞明多泪，头痛眩晕，目暗不明，大便秘结。
丹参为唇形科植物丹参Salvia miltiorrhiza Bunge. 的干燥根及根茎。性味苦，微寒。归经归心、肝经。功能主治祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
赤芍为毛茛科植物芍药Paeonia lactiflora Pall.或川赤芍Paeonia veitchiiLynch 的干燥根。性味苦，微寒。归经归肝经。功能主治清热凉血，散瘀止痛。用于温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，症瘕腹痛，跌扑损伤，痈肿疮疡。
木贼为木贼科植物木贼Equisetum hiemale L.的干燥地上部分。性味甘、苦，平。归经归肺、肝经。功能主治散风热，退目翳。用于风热目赤，迎风流泪，目生云翳。
黄芪为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var.mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。性味甘，温。归经归肺、脾经。功能主治补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
黄连为毛茛科植物黄连Coptis chinensis Franch.、三角叶黄连Coptisdeltoidea C. Y. Cheng et Hsiao或云连Coptis teeta Wall.的干燥根茎。性味苦，寒。归经归心、脾、胃、肝、胆、大肠经。功能主治清热燥湿，泻火解毒。
冰片为无色透明或白色半透明的片状松脆结晶；性味辛、苦，微寒。归经归心、脾、肺经。功能主治开窍醒神，清热止痛。用于热病神昏、痉厥，中风痰厥，气郁暴厥，中恶昏迷，目赤，口疮，咽喉肿痛，耳道流脓。
川芎活血行气，祛风止痛。用于安抚神经，正头风头痛，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
采用上述技术方案所产生的有益效果在于：
本发明根据中医理论和经验医学，严格遵从中药七情配伍，科学调配各组方，各组方共用，达到治疗视力亚健康并促进营养吸收的效果。菊花决明子平肝明目、清热通便；密蒙花明目退翳；柴胡疏肝止痛；蒺藜平肝活血；薄荷蝉蜕宣散风热；红花丹参活血痛经；川芎活血行气；冰片开窍醒神；赤芍清热散瘀； 木贼退目翳；黄芪补气；黄连清热解毒；诸药合用协同共奏舒经通络，健脾益气，清热解毒，活血行气，促进循环，排毒明目之效。
本发明所提供的膏剂直接涂抹到人体上的经络穴位，无任何毒副作用， 只外敷，不涉及内服，不会危及到人体健康，通过疏通肝胆经络，增强人体肝胆的排毒功能，从而保证眼睛的微量元素的供给，对视力亚健康起到良好的调理效果，同时还可以增强人体对食物中营养的吸收效果，从而增加人体免疫力。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面结合具体实施例对发明进行清楚、完整的描述。
实施例1
活络膏配方，由如下原料组成：菊花100克，密蒙花100克，柴胡60克，蒺藜80克，蝉蜕60克，红花60克，薄荷80克，决明子80克，丹参40克，赤芍40克，木贼60克，黄芪60克，黄连60克，冰片10克，川芎80克，硬脂酸300克，凡士林50克，甘油50克，三乙醇胺25克。
其由以下步骤制备：
1)按重量份称取活性组分药材粉碎成颗粒放入砂锅内，加入以上药材8倍重量的水，武火至沸腾，转文火熬1.5小时，过滤将药液倒出，药渣中再次加入初次加入药材4倍重量的水，武火至沸腾，转文火熬1小时，过滤将药液倒出；
2)将二次熬制的药液一起再次熬制，待总重量为活性组分药材总重量2.5倍时，得到浓缩液；
3)将浓缩液温度降至60-80℃度，加入硬脂酸，凡士林和甘油，搅拌至全部溶解；
4) 加入三乙醇胺乳化成膏，冷却后即得。
实施例2
活络膏配方，菊花80份，密蒙花120份，柴胡50份，蒺藜95份，蝉蜕50份，红花70份，薄荷65份，决明子95份，丹参32份，赤芍48份，木贼50份，黄芪70份，黄连50份，冰片14份，川芎65份，硬脂酸200份，凡士林60份，甘油40份，三乙醇胺27份。
其由以下步骤制备：
1)按重量份称取活性组分药材粉碎成颗粒放入砂锅内，加入以上药材10倍重量的水，武火至沸腾，转文火熬1.5小时，过滤将药液倒出，药渣中再次加入初次加入药材3倍重量的水，武火至沸腾，转文火熬1小时，过滤将药液倒出；
2)将二次熬制的药液一起再次熬制，待总重量为活性组分药材总重量3倍时，得到浓缩液；
3)将浓缩液温度降至60-80℃度，加入硬脂酸，凡士林和甘油，搅拌至全部溶解；
4) 加入三乙醇胺乳化成膏，冷却后即得。
实施例3
活络膏配方，由如下原料组成：菊花120份，密蒙花80份，柴胡70份，蒺藜65份，蝉蜕70份，红花50份，薄荷95份，决明子65份，丹参48份，赤芍32份，木贼70份，黄芪50份，黄连70份，冰片6份，川芎95份，硬脂酸200份，凡士林60份，甘油40份，三乙醇胺27份。
其由以下步骤制备：
1)按重量份称取活性组分药材粉碎成颗粒放入砂锅内，加入以上药材6倍重量的水，武火至沸腾，转文火熬1.5小时，过滤将药液倒出，药渣中再次加入初次加入药材5倍重量的水，武火至沸腾，转文火熬1小时，过滤将药液倒出；
2)将二次熬制的药液一起再次熬制，待总重量为活性组分药材总重量2倍时，得到浓缩液；
3)将浓缩液温度降至60-80℃度，加入硬脂酸，凡士林和甘油，搅拌至全部溶解；
4) 加入三乙醇胺乳化成膏，冷却后即得。
效果例
采用本发明中实施例1制备的活络膏，做如下临床试验 ：
分别选取50名20岁-35岁的轻年视疲劳患者（眼干眼涩），50名11岁-17岁的青少年假性近视，施予实施例1制备的活络膏，进行试验。
具体试验方法：取9g活络膏平均分成10份，分别涂抹于：瞳子髎穴、清明穴、明目穴、肩井穴、光明穴、风池穴、印堂穴、太空穴、液门穴、太冲穴，24小时换药一次，9日为一疗程，时间2个疗程。
临床试验结果如下：
选取的50名20岁-35岁的轻年视疲劳患者试验组，100眼，其中有效者(视疲劳症状得到缓解)25眼，占25％，显著者(视疲劳症状基本消失)71眼，占71％，总有效率达96％。
选取的1岁-17岁的青少年假性近视患者试验组，100眼，其中有效者（视力提高一个格）37眼，占37%，显著者（视力提高两个格以上）58眼，占58%，总有效率达95%。
最后应说明的是：以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。

Claims (5)

1.一种活络膏配方，其特征在于，其由如下活性组分组成：菊花80-120份，密蒙花80-120份份，柴胡50-70份，蒺藜65-95份，蝉蜕50-70份，红花50-70份，薄荷65-95份，决明子65-95份，丹参32-48份，赤芍32-48份，木贼50-70份，黄芪50-70份，黄连50-70份，冰片6-14份，川芎65-95份。
2.根据权利要求1所述的一种活络膏配方，其特征在于，其由如下活性组分组成：菊花100份，密蒙花100份，柴胡60份，蒺藜80份，蝉蜕60份，红花60份，薄荷80份，决明子80份，丹参40份，赤芍40份，木贼60份，黄芪60份，黄连60份，冰片10份，川芎80份。
3.根据权利要求1或2所述的一种活络膏配方，其特征在于，还包括如下辅料：硬脂酸200-400份，凡士林40-60份，甘油40-60份，三乙醇胺22-27份。
4.一种如权利要求1-3任一项所述的膏剂的制备方法，其特征在于，具体步骤如下：
1)按重量份称取活性组分药材粉碎成颗粒放入砂锅内，加入以上药材6-10倍重量的水，武火至沸腾，转文火熬1.5小时，过滤将药液倒出，药渣中再次加入初次加入药材3-5倍重量的水，武火至沸腾，转文火熬1小时，过滤将药液倒出；
2)将二次熬制的药液一起再次熬制，得到浓缩液；
3)将浓缩液温度降至60-80℃度，加入硬脂酸，凡士林和甘油，搅拌至全部溶解；
4) 加入三乙醇胺乳化成膏，冷却后即得。
5.根据权利要求4所述的一种膏剂的制备方法，其特征在于，所述浓缩液的重量为初次加入活性组分药材重量的2-3倍。
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