CN106963727A - Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product and preparation method thereof - Google Patents
Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product and preparation method thereof Download PDFInfo
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- CN106963727A CN106963727A CN201710402693.0A CN201710402693A CN106963727A CN 106963727 A CN106963727 A CN 106963727A CN 201710402693 A CN201710402693 A CN 201710402693A CN 106963727 A CN106963727 A CN 106963727A
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- sodium hyaluronate
- antibacterial peptide
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- scar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
A kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product, including following raw material：420 600 parts of 0.5 10 parts of antibacterial peptide, 100 200 parts of dimethyl silicone polymer, 100 200 parts of Dimethicone Crosspolymer, 10 50 parts of sodium hyaluronate, 46 parts of carbomer, 58 parts of triethanolamine, 100 150 parts of glycerine and purified water；Compound method：1st, sodium hyaluronate solution is made in purified water and sodium hyaluronate；2nd, antibacterial peptide solution is made in purified water and antibacterial peptide；3rd, glycerine, purified water and triethanolamine are sequentially added in carbomer carbomer solution is made；4th, sodium hyaluronate solution and antibacterial peptide solution are added into carbomer solution stirring successively, adds dimethyl silicone polymer and Dimethicone Crosspolymer stirs, crossed colloid mill and obtain finished product.The present invention can treat and prevent scar；Anti-inflammation；Protection, antalgesic-antipruritic；Strength water lock, soften and repair scar.
Description
Technical field
Product technical field is repaired the present invention relates to skin scar, and in particular to a kind of silicon comprising sodium hyaluronate and antibacterial peptide
Gel scar of dispelling repairs product and preparation method thereof.
Background technology
In burn, wound and surgical site infections, because skin soft tissue is badly damaged at wound healing, it is impossible to completely voluntarily
Repair, and hyperplastic scar or keloid are formed by fibrous tissue replacement, leave influence skin function and local disease attractive in appearance
Shape.According to 2012 years of southern institute according to statistics：There is nearly 400,000,000 people to be perplexed by scar in China.Scar annoyings the normal life of people
Work, study, marriage etc., especially when scar formation is in exposed position, have a strong impact on and hit the self-esteem of people, clinical at present
Medical science is substantially repaired by performing the operation and medicine softens means and treated, this treatment method cycle length, somewhat expensive.Cause
This, studying the method and product of No operation prevention of scar turns into the problem that domestic and international medical field is paid close attention to jointly.
At present, the skin scar reparation product category of in the market is more.Such as Chinese invention patent（Patent No.
ZL200410096766.0）Disclose " a kind of preparation method of silicon gel carrying silver ion ", this method mainly adds Ludox
Enter into the silver nitrate solution containing surfactant, obtain silicon gel carrying silver ion.It possesses certain antibacterial effect, still
Moisturizing, aquation effect are poor, and the uncomfortable symptom such as rubefaction, allergy, itch, tight occurs in use.Chinese invention
Patent application（Number of patent application is 201510503456.4）Disclosing one kind " prevents the sodium hyaluronate of scar formation and Complicated primary
Silica hydrogel composition and preparation method ", this method introduces sodium hyaluronate composition in traditional Silica hydrogel product and onion is extracted
Thing, greatly improves moisturizing, the aquation effect of Silica hydrogel product, but its fungistatic effect awaits improving.
Therefore, needing one kind badly in the prior art has treatment and prevention scar effect, there is extremely strong anti-inflammation ability again
And the skin scar of moisturizing aquation effect repairs product.
The content of the invention
The invention aims to overcome the shortcomings of that prior art has that there is provided a kind of sodium hyaluronate and antibacterial peptide of including
Silica hydrogel dispel scar repair product, it has quadruple effect：1st, potent treatment and prevention scar；2nd, extremely strong antimicrobial and anti-inflammation efficacy；
3rd, protection, antalgesic-antipruritic excellent；4th, strength water lock, aquation, soften and repair scar.
The present invention is achieved by the following technical solutions：A kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide is dispelled scar reparation
Product, includes the raw material of following parts by weight：0.5-10 parts of antibacterial peptide, 100-200 parts of dimethyl silicone polymer, polydimethylsiloxanes
100-200 parts of alkane cross-linked polymer, 10-50 parts of sodium hyaluronate, 4-6 parts of carbomer, 5-8 parts of triethanolamine, 100-150 parts of glycerine
With 420-600 parts of purified water；
Compound method：The first step, take purified water to add to stir into sodium hyaluronate, sodium hyaluronate solution is made；Second step, take again
Purified water is added to stir into antibacterial peptide, and antibacterial peptide solution is made；3rd step, first carbomer is added in glycerine and stirred
Mix, it is to be dissolved after, add purified water and stir, stand more than 4 hours, then add triethanolamine regulation pH to 6.5-
7.2, carbomer solution is made；4th step, sodium hyaluronate solution and antibacterial peptide solution is added to the card ripple that the 3rd step is made successively
Stirred in nurse solution, add dimethyl silicone polymer and Dimethicone Crosspolymer stirs, cross colloid mill,
Finished product.
Preferably, including the raw material of following parts by weight：5 parts of antibacterial peptide, 150 parts of dimethyl silicone polymer, poly dimethyl
150 parts of Dimethicone Crosspolymer, 25 parts of sodium hyaluronate, 5 parts of carbomer, 5 parts of triethanolamine, 100 parts of glycerine and purified water 600
Part.
Wherein, sodium hyaluronate and antibacterial peptide are all the materials that human body is inherently present.Sodium hyaluronate is also known as hyaluronic acid, is fell
One of main matrix composition of skin epidermis and corium, its physiological function is that moisture can be made to enter space between cells, and with protein knot
Close and form protein gel, cell is sticked together, holding cell moisture, protection are played in the cell metabolism effect brought into normal play
Cell is not encroached on by pathogen, is accelerated to recover skin histology, is improved Wound healing power of regeneration, reduces scar, and enhancing is immune
Power etc. is acted on.Meanwhile, hyaluronic acid is the main component of proliferative cell and migrating cell extracellular matrix, especially in embryonic tissue
It is such.Because the characteristic of itself of hyaluronic acid, can maintain separately from each other cell, cell is set to be easy to motion migration and breed
And prevent cell differentiation.In growth course, the effect of hyaluronic acid seemingly prevents cell from breeding enough or migrating in place
Broken up too early before.
Antibacterial peptide former, which refers to the class produced in insect bodies through induction, has the basic polypeptide material of antibacterial activity, molecular weight
2000~7000 or so, it is made up of 20~60 amino acid residues.Initially, immunologic mechanism of the people in research North America giant silkworm
When, it is found that after its diapause pupae is induced through environmental stimuli, the peptide material with bacteriostasis is generated in its hemolymph, it is this kind of anti-
Bacterium polypeptide is named as cecropin (Cecropins).Later, from other insects and amphibian animal, mammal, also divide
From to the similar antibacterial polypeptide of structure, the structure for having more than 70 kinds of antibacterial polypeptide is measured.Between several years after 1980, people are successive
Find and separate to obtain with antibacterial activity from bacterium, fungi, amphibian animal, insect, higher plant, mammal or even the mankind
Polypeptide.The extended familys that the alexin found in human body belongs in antibacterial peptide, according to the space structure of its amino acid
It is divided into three major types again with the difference of Secreting section:Human α-defensin (humand α-defensin), people's beta-alexin (human β-
Defensin, H β D), people θ-alexin (human θ-defensin) [5], it has now been found that human alpha-defensin up to more than 35 kinds, wherein
Very important defence have 10 kinds.Because this kind of active peptides have broad-spectrum high efficacy bactericidal activity to bacterium, thus it is named as
" antibacterial pepitides, ABP ", Chinese is translated into antibacterial peptide, and its original meaning is antibacterium peptide.As people study work
That makees carries out in a deep going way, it is found that some antibacterium peptides are respectively provided with strong killing to some fungi, protozoon, virus and cancer cell etc.
Effect.
The beneficial effects of the invention are as follows：1st, potent treatment and prevention scar：The international scar treatment guide of addition is recommended most
The dimethyl silicone polymer and Dimethicone Crosspolymer of new standard, it is lazy with good chemical stability and physiology
Property, the tension force in scar body surface face can be significantly decreased, suppresses collagenous fibres synthesis, prevention of scar is formed, while correcting growth
It is not enough or excessive, bidirectional modulation growth factor（Such as BFGF）, repair and treatment scar；2nd, extremely strong antimicrobial and anti-inflammation efficacy：Addition
Antibacterial peptide components, antibacterial peptide belongs to bio-extract, with extremely strong antibacterial and anti-inflammation functions, and bacterium is killed rapidly, and will not
Produce allergic reaction；3rd, protection, antalgesic-antipruritic：The present invention can quickly form closing pellicle at scar, and isolation bacterium enters
Invade and recover stratum corneum barrier function, prevent moisture loss, reach aquation protection, the effect of antalgesic-antipruritic, while beneficial to scar
Softening, it is smooth, calm down；4th, strength water lock, aquation, soften and repair scar：Sodium hyaluronate composition is with the addition of, its hyalomitome molecule
More than 500 times of moisture, strength water lock, with extremely strong moisturizing aquation effect, while wound repair can be promoted can be carried.
Embodiment
Embodiment 1
A kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product, includes the raw material of following parts by weight：Antibacterial peptide 0.5
Part, 100 parts of dimethyl silicone polymer, 100 parts of Dimethicone Crosspolymer, 10 parts of sodium hyaluronate, 4 parts of carbomer, three
420 parts of 5 parts of monoethanolamine, 100 parts of glycerine and purified water；
Compound method：The first step, take 140 parts of purified waters to add to stir into sodium hyaluronate, sodium hyaluronate solution is made；Second
Step, take 140 parts of purified waters to add again to stir into antibacterial peptide, antibacterial peptide solution is made；3rd step, first carbomer added
Into glycerine stir, it is to be dissolved after, add 140 parts of purified waters and stir, stand more than 4 hours, then add three
Monoethanolamine adjusts pH to 6.5, and carbomer solution is made；4th step, sodium hyaluronate solution and antibacterial peptide solution is added to successively
Stirred in the carbomer solution that three steps are made, add dimethyl silicone polymer and Dimethicone Crosspolymer stirring
Uniformly, colloid mill, finished product are crossed.
Embodiment 2
A kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product, includes the raw material of following parts by weight：Antibacterial peptide 10
Part, 200 parts of dimethyl silicone polymer, 200 parts of Dimethicone Crosspolymer, 50 parts of sodium hyaluronate, 6 parts of carbomer, three
480 parts of 8 parts of monoethanolamine, 150 parts of glycerine and purified water；
Compound method：The first step, take 160 parts of purified waters to add to stir into sodium hyaluronate, sodium hyaluronate solution is made；Second
Step, take 160 parts of purified waters to add again to stir into antibacterial peptide, antibacterial peptide solution is made；3rd step, first carbomer added
Into glycerine stir, it is to be dissolved after, add 160 parts of purified waters and stir, stand more than 4 hours, then add three
Monoethanolamine adjusts pH to 7.2, and carbomer solution is made；4th step, sodium hyaluronate solution and antibacterial peptide solution is added to successively
Stirred in the carbomer solution that three steps are made, add dimethyl silicone polymer and Dimethicone Crosspolymer stirring
Uniformly, colloid mill, finished product are crossed.
Embodiment 3
A kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product, includes the raw material of following parts by weight：Antibacterial peptide 5
Part, 150 parts of dimethyl silicone polymer, 150 parts of Dimethicone Crosspolymer, 25 parts of sodium hyaluronate, 5 parts of carbomer, three
600 parts of 5 parts of monoethanolamine, 100 parts of glycerine and purified water；
Compound method：The first step, take 200 parts of purified waters to add to stir into sodium hyaluronate, sodium hyaluronate solution is made；Second
Step, take 200 parts of purified waters to add again to stir into antibacterial peptide, antibacterial peptide solution is made；3rd step, first carbomer added
Into glycerine stir, it is to be dissolved after, add 200 parts of purified waters and stir, stand more than 4 hours, then add three
Monoethanolamine adjusts pH to 7.0, and carbomer solution is made；4th step, sodium hyaluronate solution and antibacterial peptide solution is added to successively
Stirred in the carbomer solution that three steps are made, add dimethyl silicone polymer and Dimethicone Crosspolymer stirring
Uniformly, colloid mill, finished product are crossed.
By a large amount of clinical tests confirm, Silica hydrogel made from three above embodiment dispel scar repair product be respectively provided with prevention
Scar formation, treatment scar, anti-inflammation, antalgesic-antipruritic, completely cut off bacterial invasion and avoid the effect of moisture loss.Wherein, it is real
The effect for applying example 3 is optimal.
Antibacterial peptide with anti-inflammation function and the sodium hyaluronate for possessing superpower moisturizing aquation effect are incorporated into by the present invention
In Silica hydrogel, prepare a kind of medical composite silica gel scar of dispelling and repair product, and its processing technology is simple, production cost
It is low, it is with short production cycle, it is suitable to produce in enormous quantities.
Finally it should be noted that above content is merely illustrative of the technical solution of the present invention, rather than to present invention protection
The limitation of scope, simple modification or equivalent substitution that one of ordinary skill in the art is carried out to technical scheme,
All without departing from the spirit and scope of technical solution of the present invention.
Claims (2)
1. a kind of Silica hydrogel comprising sodium hyaluronate and antibacterial peptide is dispelled, scar repairs product, it is characterised in that：
Include the raw material of following parts by weight：0.5-10 parts of antibacterial peptide, 100-200 parts of dimethyl silicone polymer, polydimethylsiloxanes
100-200 parts of alkane cross-linked polymer, 10-50 parts of sodium hyaluronate, 4-6 parts of carbomer, 5-8 parts of triethanolamine, 100-150 parts of glycerine
With 420-600 parts of purified water；
Compound method：The first step, take purified water to add to stir into sodium hyaluronate, sodium hyaluronate solution is made；Second step, take again
Purified water is added to stir into antibacterial peptide, and antibacterial peptide solution is made；3rd step, first carbomer is added in glycerine and stirred
Mix, it is to be dissolved after, add purified water and stir, stand more than 4 hours, then add triethanolamine regulation pH to 6.5-
7.2, carbomer solution is made；4th step, sodium hyaluronate solution and antibacterial peptide solution is added to the card ripple that the 3rd step is made successively
Stirred in nurse solution, add dimethyl silicone polymer and Dimethicone Crosspolymer stirs, cross colloid mill,
Finished product.
2. the Silica hydrogel according to claim 1 comprising sodium hyaluronate and antibacterial peptide is dispelled, scar repairs product, it is characterised in that bag
Include the raw material of following parts by weight：5 parts of antibacterial peptide, 150 parts of dimethyl silicone polymer, Dimethicone Crosspolymer 150
Part, 25 parts of sodium hyaluronate, 5 parts of carbomer, 5 parts of triethanolamine, 100 parts of glycerine and 600 parts of purified water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710402693.0A CN106963727A (en) | 2017-06-01 | 2017-06-01 | Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710402693.0A CN106963727A (en) | 2017-06-01 | 2017-06-01 | Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product and preparation method thereof |
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| CN106963727A true CN106963727A (en) | 2017-07-21 |
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| CN201710402693.0A Pending CN106963727A (en) | 2017-06-01 | 2017-06-01 | Silica hydrogel comprising sodium hyaluronate and antibacterial peptide scar of dispelling repairs product and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020249040A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883520B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883368B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11904041B2 (en) | 2019-06-14 | 2024-02-20 | The Procter & Gamble Company | Leave-on oral care compositions |
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| CN103536960A (en) * | 2013-10-30 | 2014-01-29 | 无锡灵锡医疗器械科技有限公司 | Hydrogel capable of slowly releasing antibacterial peptide as well as preparation method thereof |
| CN103611181A (en) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | Antibacterial peptide hydrogel and preparation method thereof |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
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2017
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Patent Citations (3)
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| CN103611181A (en) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | Antibacterial peptide hydrogel and preparation method thereof |
| CN103536960A (en) * | 2013-10-30 | 2014-01-29 | 无锡灵锡医疗器械科技有限公司 | Hydrogel capable of slowly releasing antibacterial peptide as well as preparation method thereof |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020249040A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883520B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11883368B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11904041B2 (en) | 2019-06-14 | 2024-02-20 | The Procter & Gamble Company | Leave-on oral care compositions |
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Application publication date: 20170721 |
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