CN106942269A - A kind of device for preparing disinfectant nano particle - Google Patents
A kind of device for preparing disinfectant nano particle Download PDFInfo
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- CN106942269A CN106942269A CN201710169277.0A CN201710169277A CN106942269A CN 106942269 A CN106942269 A CN 106942269A CN 201710169277 A CN201710169277 A CN 201710169277A CN 106942269 A CN106942269 A CN 106942269A
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- disinfectant
- vaporization
- nano particle
- particle
- storing liquid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
Abstract
This application discloses a kind of device for preparing disinfectant nano particle.The device of the disinfectant nano particle includes device for storing liquid, and the device for storing liquid is used to store the disinfectant；Spraying system, the spraying system is connected with the device for storing liquid, for the disinfectant in the device for storing liquid to be suctioned out, and is particle by disinfectant atomization；Piece-rate system is vaporized, the vaporization piece-rate system is connected with the spraying system, for vaporizing the particle for nanometer mist；Cyclone separation system, the cyclone separation system is connected with the vaporization piece-rate system, for receiving the nanometer mist in the vaporization piece-rate system, and the nanometer mist is dried, separated, and forms the disinfectant nano particle.
Description
Technical field
The application is related to the device for preparing disinfectant nano particle.
Background technology
It is well known that vaporization is that material is changed into a kind of gaseous process from liquid, generally there are two kinds of shapes of evaporation and boiling
Formula.A kind of gentle vaporescence in liquid surface simply occurs for evaporation, can occur at any temperature, the temperature of liquid
The higher, surface area of degree is bigger and ventilation effect is better, and the speed for vaporizing (evaporation) is faster.Boiling is same at the same temperature
Shi Fasheng is in liquid surface and a kind of internal violent vaporescence, and every kind of liquid is only when its temperature is raised and reaches boiling temperature
Shi Caihui seethes with excitement.Although evaporation has no essential distinction with boiling in phase transformation, for inflammable and explosive and unstable material
Blast is just easily produced for such as hydrogen peroxide and Peracetic acid, during boiling or destruction is decomposed.
Space is carried out disinfection or sterilized generally using spraying or stifling (high-temperature evaporation) 2 kinds of modes using thimerosal.By
It is smaller than spraying in fumigating produced particle, easily spread in atmosphere, thus effect is relatively preferable, using scope also compared with
It is wide.The mode that the disinfectant such as using propane diols, lactic acid, Peracetic acid, hydrogen peroxide and formaldehyde is fumigated disappears to space
Poison or sterilizing are all obtained a wide range of applications.
But, in the prior art, otherwise the disinfectant particle produced is larger can not to reach Disinfection Effect, and containing a large amount of
Moisture or steam equipment or wall surface can be made to moisten and produce corrosiveness；The excessive concentration of the disinfectant used,
And then causing corrosion strengthen, especially with high concentration hydrogen peroxide during high-temperature evaporation because hydrogen peroxide decompose
Large quantity of moisture can be produced, also there is stronger corrosiveness to color steel and epoxy ground.No matter use that method system
Standby disinfectant particle, can all contain substantial amounts of moisture or water vapour, thus also inevitably produce corruption to some body surfaces
Erosion is acted on.
Accordingly, it would be desirable to develop it is a kind of it is new prepare the short grained device of disinfectant, to overcome the defect of prior art.
The content of the invention
In order to overcome the defect of prior art, this application provides a kind of device for preparing disinfectant nano particle, it is wrapped
Device for storing liquid is included, it is used to store the disinfectant；Spraying system, it is connected with the device for storing liquid, for by the liquid storage
The disinfectant in device is suctioned out, and is particle by disinfectant atomization；Vaporize piece-rate system, itself and the spraying system
Connection, for vaporizing the particle for nanometer mist；Cyclone separation system, it is connected with the vaporization piece-rate system, for receiving
The nanometer mist in the vaporization piece-rate system, and the nanometer mist is dried, is separated, form the disinfectant
Nano particle.
In a detailed embodiment, it is described vaporization piece-rate system and the cyclone separation system respectively with the liquid storage
Device is connected.
In a detailed embodiment, the spraying system includes
Air cleaner, its first end is contacted with the external world；
At least one blower fan and/or air compressor, its first end are connected with the second end of the air cleaner；
Atomizer, it is connected by ventilation shaft with the blower fan and/or the end of air compressor second；And the spray
Mist system is connected by the atomizer with the vaporization piece-rate system.
In a detailed embodiment, the vaporization piece-rate system includes
Vaporization separation body, it is connected with the atomizer, and the particle is sprayed into institute during the atomizer work
State in the cavity that vaporization separation body is enclosed；
Nanometer mist delivery outlet, it is located on the vaporization separation body, and is connected with the cyclone separation system.
Preferably, vaporization separation body is at least two vaporization separation bodies being sequentially connected with.
In a detailed embodiment, the cyclone separation system includes
Cyclonic separation body；
Nanometer mist input port, it is located on the cyclonic separation body, and is connected with the nanometer mist delivery outlet；
Solvent vapo(u)r outlet, it is located at the top of the cyclonic separation body, for discharging what is produced in drying process
Solvent vapo(u)r；
Disinfectant nano particle delivery outlet, it is located on the cyclonic separation body, for exporting the disinfectant nanometer
Particle.
Preferably, the cyclonic separation body is at least two cyclonic separation bodies being sequentially connected with.
In a detailed embodiment, the vaporization piece-rate system also includes the first disinfectant and assembles mouth, described first
Disinfectant aggregation mouth is located at the bottom of the vaporization separation body, and is connected with the device for storing liquid.
In a detailed embodiment, the cyclone separation system also includes the second disinfectant and assembles mouth, described second
Disinfectant aggregation mouth is located at the bottom of the cyclonic separation body, and is connected with the device for storing liquid.
In a detailed embodiment, the cyclone separation system also includes pneumatic filter, the pneumatic filter
Positioned at the lower section of the solvent vapo(u)r outlet.
In a detailed embodiment, the cyclone separation system is shaped as cylindricality, taper or cylindricality and taper
Combination.
In a detailed embodiment, described device also includes
Decontaminant concentration detection means, it is connected with the disinfectant nano particle delivery outlet, the institute for detecting output
State the concentration of disinfectant nano particle；
Circuit control system, it is connected with the spraying system, the decontaminant concentration detection means respectively；
Shell, is provided with the first hole, described molten in the first end of the air cleaner and the junction of the shell
The junction of agent steam outlet and the shell is provided with the second hole；The disinfectant nano particle delivery outlet with it is described outer
The junction of shell is provided with the 3rd hole；
Roller, it is arranged at the bottom of the shell.
In a detailed embodiment, the solvent can be water and/or ethanol.
The beneficial effect that the application can be produced includes：
(1) using the device of the application, prepared disinfectant nano particle is not only very small and relatively dry, greatly
Part can reach nanoscale, can suspend for a long time in atmosphere, and fully contacted with the bacterium in air and reach sterilized mesh
, and there is no corrosiveness to color steel and epoxy ground.Prior art disinfectant is solved in the particle for vaporizing or being atomized
In exist a large amount of solvents or solvent vapo(u)r and decomposition the problem of, improve its sterilization effect, and reduce its corrosivity.
Can be widely used in it is various can confined space sterilization.
Specifically, it is not only able to produce the disinfectant grain diameter size for being satisfied with Disinfection Effect.I.e. it is produced
Disinfectant grain diameter is less than 5 μm；Its disinfectant grain diameter produced can reach 95% less than 3 μm；Its disinfectant produced
Grain diameter can reach 85% less than 2 μm；Its disinfectant grain diameter produced can reach 72% less than 1 μm；What it was produced disappears
Toxic agent grain diameter can reach 53% less than 0.5 μm；Its disinfectant grain diameter produced can reach 28% less than 0.3 μm.And
And the relative humidity of its disinfectant particle that can make generation is reduced to 40%, and then greatly reduce disinfectant nano particle pair
The corrosion of sterilizing equipment decontaminating apparatus and/or the wall being sterilized.
Even if only carrying out one cyclonic separation, the disinfectant grain diameter that it is produced is also below 5 μm；Its disinfectant produced
Grain diameter can reach 93% less than 3 μm；Its disinfectant grain diameter produced can reach 81% less than 2 μm；What it was produced disappears
Toxic agent grain diameter can reach 67% less than 1 μm；Its disinfectant grain diameter produced can reach 49% less than 0.5 μm；It is produced
Raw disinfectant grain diameter can reach 25% less than 0.3 μm.And the relative humidity of its disinfectant particle that can make generation
It is reduced to 60%.Its also while Disinfection Effect is met, can substantially reduce disinfectant nano particle to sterilizing equipment decontaminating apparatus and/or
The corrosion for the wall being sterilized.
And it can be seen from the result more than, the disinfectant that can not only improve smaller particle using the equipment of the application is received
Ratio shared by rice grain particle diameter, and the relative humidity of disinfectant nano particle can be effectively reduced.
(2) the application only needs to provide air and the peroxidating using low concentration using cheap blower fan or air compressor
Hydrogen thimerosal.
(3) it is different from hydrogen peroxide (the general 30- that existing high-temperature evaporation technology (VHP technologies) needs to use high concentration
50%) and at least 130 DEG C temperature flash evaporation technology to it is each drop thimerosal (note：About 400 μm or so of the particle diameter of 1 drop thimerosal)
Being vaporized can cause a large amount of hydrogen peroxide to decompose.The application is due to first using spray technique by disinfectant liquid atomization to 10 μm or so
Little particle, recycle the size particles different principle of elasticity to carry out isolated average grain diameter to size particles and be less than 1 μm
More little particle, substantially increases the surface area of thimerosal, improves the carburation by evaporation efficiency under cryogenic conditions.Therefore it can make
With the hydrogen peroxide of low concentration, (general less than 6%) is under low temperature (room temperature) using high speed circulation air to Hydrogen Peroxide Disinfection Solution
It is evaporated vaporization, it is to avoid existing VHP technologies cause decomposition destruction and the corrosiveness of a large amount of hydrogen peroxide, while
Can reach high concentration hydrogen peroxide is identical or more preferable sterilization effect.
Brief description of the drawings
Fig. 1 is the apparatus structure schematic diagram provided in an embodiment of the present invention for preparing disinfectant nano particle.
Part and reference numerals list：
1 spraying system,
11 blower fans or air compressor, 12 air cleaners, 13 atomizers, 14 supports,
21 device for storing liquid, 22 solvent filters, 23 liquid-transport pipe-lines, 24 recovery channels,
3 vaporization piece-rate systems,
31 vaporization separation bodies, 32 cavitys, 33 nanometers of mist delivery outlets, 34 first disinfectants aggregation mouth,
4 cyclone separation systems,
41 nanometers of mist input ports, 42 solvent vapo(u)r outlets, 43 disinfectant nano particle delivery outlets, 44 second thimerosals gather
Ji Kou, 45 filters, 46 cyclonic separation bodies,
5 decontaminant concentration detection means,
6 circuit control systems,
7 shells,
71 first holes, 72 second holes, 73 the 3rd holes,
8 rollers.
Embodiment
The application is described in detail with reference to embodiment, but the application is not limited to these embodiments.
Embodiment 1
As shown in figure 1, being vaporized separation this application provides a kind of to disinfectant under cryogenic and preparing disinfectant
The device of nano particle, the device includes being used to be atomized disinfectant to form short grained spraying system 1, and storage has disinfectant
Device for storing liquid 21, for the disinfectant little particle after atomization to be separated, carburation by evaporation formation more little particle (nanometer mist)
Vaporize piece-rate system 3 and the cyclone separation system 4 for being dried, separating by the nanometer mist of the formation after separation of vaporization.Institute
Device for storing liquid 21 is stated to be connected with the spraying system 1, the vaporization piece-rate system 3 and cyclone separation system 4 respectively.The spraying
System 1, the vaporization piece-rate system 3 and the cyclone separation system 4 are sequentially connected.The device for storing liquid 21 respectively with the vapour
Change piece-rate system 3 and cyclone separation system 4 is connected, gather for reclaiming in the vaporization piece-rate system 3 and cyclone separation system 4
The thimerosal of collection.
Specifically, device for storing liquid 21 can be using the containers such as liquid storage bottle, the device for storing liquid 21 and liquid-transport pipe-line 23 and recovery
Pipeline 24 is connected.The device for storing liquid 21 is stored with the disinfectant.The solvent filter is provided with the liquid-transport pipe-line 23
Device 22, and the first end of the liquid-transport pipe-line 23 is connected with the device for storing liquid 21, the second end of the liquid-transport pipe-line 23 and institute
Spraying system 1 is stated to connect.The device for storing liquid 21 vaporizes piece-rate system 3 and whirlwind with described respectively by the recovery channel 24
Separate the connection of 4 systems.
In spraying system, the first end of atomizer 13 passes through ventilation shaft and high-speed fan or air compressor 11
Outlet (i.e. the second end of ventilation shaft and high-speed fan or air compressor 11) be connected.Second end of atomizer 13
It is connected with the entrance for vaporizing piece-rate system 3.Atomizer 13 is also connected by liquid-transport pipe-line 23 with device for storing liquid 21 simultaneously,
Thimerosal in device for storing liquid 21 can be sucked and be atomized by atomizer 13 in the presence of negative pressure or micro electric pump, will
The particle of atomization is released in the vaporization piece-rate system.
Specifically, the spraying system 1 includes at least one blower fan or air compressor 11, at least one atomizer
13rd, support 14 and air cleaner 12.Second end of the blower fan or air compressor 11 and the first of the atomizer 13
End is connected by ventilation shaft.The first end of the blower fan or air compressor 11 and the second end of the air cleaner 12 connect
Connect.Second end of the liquid-transport pipe-line 23 is connected with the atomizer 13.Second end of the atomizer 13 and the vapour
Change piece-rate system 3 to connect.Preferably, the spraying system 1 can include multiple blower fans or air compressor 11, and/or multiple
Atomizer 13, sets multiple blower fans or air compressor 11, and/or atomizer 13 quantity, for producing higher stream
The air and more atomizing particles of speed.Blower fan or air compressor 11 can provide high flow rate air for atomizer 13.Atomization
Shower nozzle 13 can be venturi high velocity projector.
Specifically, the vaporization piece-rate system 3 includes at least one vaporization separation body 31.Vaporization separation body 31 is enclosed
Form cavity 32.The bottom of vaporization separation body 31 can assemble mouth 34 provided with the first disinfectant.First disinfectant assembles mouth 34
It is connected by recovery channel 24 with device for storing liquid 21.A nanometer mist delivery outlet 33 is provided with vaporization separation body 31, nanometer mist is defeated
Outlet 33 is connected with cyclone separation system 4.Wherein, nanometer mist delivery outlet 33 can for example be arranged at the upper of vaporization separation body 31
In portion or side wall.Vaporization separation body 31 is connected with the atomizer 13, and atomizer 13 sprays into atomizing particle when working
In the cavity 32 enclosed to vaporization separation body 31.
Wherein, the quantity of atomization system 1 and vaporization piece-rate system 3 can flexibly be provided to ensure that and can produce according to actual needs
Raw sufficient amount of atomizing particle and sufficiently small atomization particle (nanometer mist particle)；As it was previously stated, atomization system 1 utilizes wind
Thimerosal in the high velocity air that machine or air compressor 11 are produced, driving device for storing liquid 21 carries out spraying and forms of different sizes
Thimerosal little particle, and input into vaporization piece-rate system 3, and it is different using the elasticity of variable grain to vaporize piece-rate system 3
Property, the different size of thimerosal particle formed after atomization is separated, will without elasticity larger particles lead to
The inwall of overflash piece-rate system 3 adsorbs to form liquid film or drop, and the drop of formation prolongs the inwall aggregation of vaporization separation body 31
Assemble mouth 34 to the first disinfectant, and be recycled to by recovery channel 24 in device for storing liquid 21.And by it is wherein flexible compared with
Little particle is separated in the presence of high velocity air, carburation by evaporation formation more little particle i.e. nanometer mist particle, finally with a high speed
Air-flow inputs from nanometer mist delivery outlet 33 and further carburation by evaporation and separation is carried out into cyclone separation system 4.
Specifically, the cyclone separation system 4 can be cylindricality or taper and cylindricality and the combination of taper.Such as scheming
In cyclone separation system 4 shown in 1, combined by cylindricality and taper and form cyclonic separation body, nanometer mist input port 41 is arranged at
Cyclonic separation body on the side wall on top (for example positioned at the side wall of cyclonic separation body 46 close to top more than 2/3 portion
Point), nanometer mist input port 41 is connected by ventilation shaft with the nanometer mist delivery outlet 33 in the separation of vaporization system 3.Solvent
Steam outlet 42 is communicated with air, and positioned at the top of cyclonic separation body 46, pneumatic filter 45 is discharged positioned at solvent vapo(u)r
The lower section of mouth 42, the second thimerosal aggregation mouth 44 is located at the bottom of cyclonic separation body 46, and the second thimerosal aggregation mouth 44 passes through
Recovery channel 24 is connected with device for storing liquid 21.
Wherein, the quantity of the cyclone separation system 4 also can be flexibly provided to ensure that to vaporization separation according to actual needs
The nanometer mist that system 3 is produced further evaporate, vaporize and separate.Because the nanometer mist produced by vaporization piece-rate system 3
In usually contain a large amount of solvents or solvent vapo(u)r, cyclone separation system 4 can enter traveling one using wind action is revolved to nanometer mist
Step ground carburation by evaporation and drying, recycle solvent different with particle diameter with the proportion of disinfectant nano particle, pass through whirlwind and filtering
Device is separated solvent and disinfectant nano particle：Solvent vapo(u)r is discharged into air, dry sterilization will be finally given
Agent nano particle is treated sterilization space and carried out disinfection sterilizing.
Preferably, the device for preparing disinfectant nano particle also includes decontaminant concentration detection means 5.Disinfectant is dense
Degree detection means 5 is connected with the disinfectant nano particle delivery outlet 43 of the cyclone separation system 4, for detecting described in output
The concentration of disinfectant nano particle.
Preferably, the device for preparing disinfectant nano particle, also including circuit control system 6.Circuit control system 6
It is connected respectively with the spraying system 1 and decontaminant concentration detection means 6.
Preferably, the device for preparing disinfectant nano particle also includes shell 7 and roller 8.The outer 7 shell bottoms are set
It is equipped with multiple rollers 8.The first end of air cleaner 12 and the junction of shell 7 are provided with the first hole 71, in solvent
The junction of steam outlet 42 and shell 7 is provided with the second hole 72；In the company of disinfectant nano particle delivery outlet 5 and shell 7
The place of connecing is provided with the 3rd hole 73.
The application recycles size particles elasticity first using spray technique by the little particle of disinfectant liquid atomization to 10 μm or so
Different property carries out the more little particle that isolated average grain diameter is less than 1 μm to size particles, significantly increases thimerosal
Surface area, improve the carburation by evaporation efficiency of the thimerosal under cryogenic conditions.Therefore the hydrogen peroxide of low concentration can be used
(general less than 6%) is evaporated vaporization to Hydrogen Peroxide Disinfection Solution under the conditions of low temperature (room temperature) using high speed circulation air,
The decomposition destruction of existing VHP technologies a large amount of hydrogen peroxide caused by high temperature evaporation is avoided, the peroxide of high concentration has also been reached
Change that hydrogen is identical or more preferable sterilization effect.
The device for preparing disinfectant nano particle of the application, it is right under the conditions of low temperature (room temperature, i.e., 25 ± 5 DEG C) to realize
Thimerosal is evaporated the purpose for vaporizing and separating and obtain dry disinfection agent nano particle, solves the sterilization of prior art preparation
Problem containing a large amount of solvents and solvent vapo(u)r in agent particle, prepared disinfectant nano particle can be suspended in sky for a long time
In gas, and fully contacted with the bacterium in air and reach sterilized purpose, and work is not corroded to color steel and epoxy ground
With.Coordinate Active Hydrogen Peroxide Disinfection Solution is used, and has the advantages that noresidue after sterilizing, pollution-free, is that one kind can
Replace the desired sanitisation sterilization technology and system of formaldehyde and ozone.
Embodiment 2
Actual analysis is carried out using experimental implementation mode
First, particle size distribution and drying effect are determined
With 6%Exemplified by Hydrogen Peroxide Disinfectant, to the disinfectant nanometer mist of the invention produced and using rotation
The size distribution for the disinfectant particle that wind separation is produced after drying is determined.Its humidity is also determined simultaneously, tied
Fruit is as follows.
1. major experimental material and facility
CLJ-BII (D) types airborne particle counter (measurement particle size scope is 0.3-5 μm), 6%Activity
Hydrogen Peroxide Disinfection Solution (sporicide performs standard Q/HHP 001-2015), hydrogen peroxide and the trace active for including 6% is silver-colored
Ion is used as stabilizer (Hubei Hepu Pharmaceutical Co., Ltd.'s production)；
2. test site
A cleaning shop in certain pharmacy corporation GMP factory buildings, the high 2.8m in workshop, wide 4.4m, long 6.5m, space cumulative volume is about
80m3。
3. experimental method
With reference to CLJ-BII (D) type airborne particle counter operation instructions, open the dust particle detector device power supply and open
Close, set relevant parameter (test period：60s, sampling quantity：28.3L/min), by the dust particle detector device sampling mouth of pipe point
Detect the particle size distribution and relative humidity of Hydrogen Peroxide Disinfection Solution in the different exits for not being placed on the present invention.
4. experimental result
Quantity corresponding to different size of particle carries out statistical analysis, the results are shown in Table shown in 1.As shown in Table 1, it is of the invention
Low-temperature vaporization technology prepare the device of disinfectant nano particle and 6% Hydrogen Peroxide Disinfection Solution be atomized and through overflash segregative line
About 0.5 μm of mean particle size produced after separation, vaporization after system, the particle less than 1 μm accounts for more than 50%, but it is relatively wet
Degree up to 95%, after first order cyclone drying system evaporation drying and separation, the particle proportion less than 1 μm is by 54%
66.5% is brought up to, relative humidity also drops to 60% by original 95%, by second level cyclone drying system evaporation drying
And after separating, particle proportion less than 1 μm brings up to 72.1% by 66.5% again, relative humidity is also by under original 95%
Drop to 40%.The method and system that the low-temperature vaporization technology of this explanation present invention prepares disinfectant nano particle is truly realized
Thimerosal is evaporated under the conditions of low temperature (room temperature) and vaporizes and separate the purpose for obtaining dry disinfection agent nano particle, is solved
Problem containing a large amount of solvents and solvent vapo(u)r in disinfectant particle prepared by prior art, prepared disinfectant nanometer can
Suspend in atmosphere for a long time, and fully contacted with the bacterium in air and reach sterilized purpose, to color steel and epoxy ground
There is no corrosiveness.
The granular size proportion and relative humidity measurement result of the different outlets of table 1.
2nd, tested for GMP workshops sterilization
By taking certain GMP medicines workshop as an example, determine this low-temperature vaporization technology and prepare disinfectant nano particle GMP workshops are disappeared
Malicious sterilization effect, specific method is as follows：
1. major experimental material
Biological indicator (bacillus stearothermophilus spore, spore amount 106CFU/ pieces, containing same lot number biological indicator
Special culture solution) and TSA, 6%Active Hydrogen Peroxide Disinfection Solution (special sporicide).
2. test site
Between GMP cleaning shops one, the high 2.8m in workshop, wide 4.4m, long 6.5m, space size about 80m3。
3. experimental method
According to workshop space size, according to 5mL/m3Use volume carry out disinfection sterilizing.Car is placed a device in when using
Between middle, 5 biological indicators and the chemical indicator of 5 hydrogen peroxide are individually positioned in the middle of workshop (numbering 3) and four
(two corner points numberings are respectively 1 and 2 to different corners in front of equipment, and two, rear corner point numbering is respectively 4 and 5), is owned
Biological indicator is disposed vertically and height from the ground is 1m, and is fully exposed in air, after thimerosal is exhausted,
The closed 90min in room, then air draft 30min are removed into the disinfectant of residual, reaching level of security, (hydrogen peroxide is dense in air
Degree is less than 1ppm), biological indicator (gemma bar) is taken out by aseptic procedure, the stearothermophilus gemma nutrient solution of reference numeral is put into
In, according to the operation instructions of purchased biological indicator, it is placed in constant incubator, is observed after being cultivated 24 hours at 55-60 DEG C.
Take simultaneously and make positive control with batch biological indicator 1.By the culture of 24 hours, if nutrient solution becomes cloudy, color was by purple
It is changed into yellow and is then determined as the positive；If nutrient solution is clarified, color nondiscolouring is then feminine gender；Continue to cultivate to the 7th day, if culture
Liquid is changed into yellow, then is determined as that sterilizing is unqualified；If nutrient solution is still purple, it is determined as that sterilizing is qualified.
(1) space disinfection effect：Test result indicate that, when 6%The consumer of active Hydrogen Peroxide Disinfection Solution
Product is 5mL/m3, seal time is 90min, you can to 80m3Room carry out disinfection sterilizing, and reach that sterilizing requires (to kill
Dead 106Spore).
(2) surface sterilization effect：Using 6%Active Hydrogen Peroxide Disinfection Solution carries out space atomization disinfection, disappears
Consumption volume is 5mL/m3, seal time is 90min.After sanitized, dish is contacted to each surface in clean area after sterilizing using TSA
(8 points are selected on 4 metopes each 2 point, ground at random) samples.During sampling, cover is opened, by sterile culture primary surface and sampling face
Directly contact, uniform face contact dish base plate, it is ensured that whole agar surfaces are uniformly fully contacted with sample point surface, contact not low
In 10 seconds, cover is covered.After sampling, wiped with appropriate disinfectant be sampled surface immediately, to remove residual agar.Will
(TSA) contact dish, which is inverted in 30 DEG C~35 DEG C constant incubators, cultivates 3 days, count detection.As a result show：When atomization volume is
5mL/m3, when seal time is 60min, the equipment cannot be only used for space disinfection, and also body surface can be carried out disinfection, sterilization
Wall and ground microbiological index afterwards meets GMP requirement.
(3) chemical indicator inspection result：Sterilize and the discoloration of chemical indicator is checked after terminating, as a result change
Indicator is learned all to change colour.
(4) measure of residual quantities of hydrogen peroxide：Sterilizing terminates rear venting 30min, and the different parts in room (refer to biology
Show that agent placement location is identical) residual quantity of hydrogen peroxide is checked with hydrogen peroxide detector, as a result respectively less than ＜ 1ppm.
The above, is only several embodiments of the application, any type of limitation is not done to the application, although this Shen
Please disclosed as above with preferred embodiment, but and be not used to limit the application, any those skilled in the art are not taking off
In the range of technical scheme, make a little variation using the technology contents of the disclosure above or modification is equal to
Case study on implementation is imitated, is belonged in the range of technical scheme.
Claims (10)
1. a kind of device for preparing disinfectant nano particle, it is characterised in that including
Device for storing liquid, it is used to store the disinfectant；
Spraying system, it is connected with the device for storing liquid, for the disinfectant in the device for storing liquid to be suctioned out, and by institute
It is particle to state disinfectant atomization；
Piece-rate system is vaporized, it is connected with the spraying system, for vaporizing the particle for nanometer mist；
Cyclone separation system, it is connected with the vaporization piece-rate system, for receiving the institute in the vaporization piece-rate system
A nanometer mist is stated, and the nanometer mist is dried, separated, the disinfectant nano particle is formed.
2. device according to claim 1, it is characterised in that the vaporization piece-rate system and the cyclone separation system point
It is not connected with the device for storing liquid.
3. device according to claim 1, it is characterised in that the spraying system includes
Air cleaner, its first end is contacted with the external world；
At least one blower fan and/or air compressor, its first end are connected with the second end of the air cleaner；
Atomizer, it is connected by ventilation shaft with the blower fan and/or the end of air compressor second；And the spraying system
System is connected by the atomizer with the vaporization piece-rate system.
4. device according to claim 3, it is characterised in that the vaporization piece-rate system includes
Vaporization separation body, it is connected with the atomizer, and the particle is sprayed into the vapour during atomizer work
Change in the cavity that separation body is enclosed；
Nanometer mist delivery outlet, it is located on the vaporization separation body, and is connected with the cyclone separation system.
5. device according to claim 4, it is characterised in that the cyclone separation system includes
Cyclonic separation body；
Nanometer mist input port, it is located on the cyclonic separation body, and is connected with the nanometer mist delivery outlet；
Solvent vapo(u)r outlet, it is located at the top of the cyclonic separation body, the solvent produced for discharging in drying process
Steam；
Disinfectant nano particle delivery outlet, it is located on the cyclonic separation body, for exporting the disinfectant nano particle.
6. device according to claim 4, it is characterised in that the vaporization piece-rate system also includes the first disinfectant and assembled
Mouthful, the first disinfectant aggregation mouth is located at the bottom of the vaporization separation body, and is connected with the device for storing liquid.
7. device according to claim 5, it is characterised in that the cyclone separation system also includes the second disinfectant and assembled
Mouthful, the second disinfectant aggregation mouth is located at the bottom of the cyclonic separation body, and is connected with the device for storing liquid.
8. device according to claim 5, it is characterised in that the cyclone separation system also includes pneumatic filter, institute
State the lower section that pneumatic filter is located at the solvent vapo(u)r outlet.
9. device according to claim 1, it is characterised in that the cyclone separation system be shaped as cylindricality, taper or
Cylindricality and the combination of taper.
10. device according to claim 5, it is characterised in that described device also includes
Decontaminant concentration detection means, it is connected with the disinfectant nano particle delivery outlet, disappears for detecting described in output
The concentration of toxic agent nano particle；
Circuit control system, it is connected with the spraying system, the decontaminant concentration detection means respectively；
Shell, the first hole is provided with the first end of the air cleaner and the junction of the shell, is steamed in the solvent
The junction of vapour outlet and the shell is provided with the second hole；In the disinfectant nano particle delivery outlet and the shell
Junction is provided with the 3rd hole；
Roller, it is arranged at the bottom of the shell.
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| CN201710169277.0A CN106942269B (en) | 2017-03-21 | 2017-03-21 | A kind of device preparing disinfectant nano particle |
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| CN201710169277.0A CN106942269B (en) | 2017-03-21 | 2017-03-21 | A kind of device preparing disinfectant nano particle |
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| CN106942269B CN106942269B (en) | 2019-09-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908320A (en) * | 2021-10-28 | 2022-01-11 | 西安泰维生物技术设备有限公司 | Atomized disinfectant generating device and drying method based on same |
| CN116481118A (en) * | 2023-06-20 | 2023-07-25 | 科瑞特空调集团有限公司 | Air sterilizing and purifying device |
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| CN113908320A (en) * | 2021-10-28 | 2022-01-11 | 西安泰维生物技术设备有限公司 | Atomized disinfectant generating device and drying method based on same |
| CN116481118A (en) * | 2023-06-20 | 2023-07-25 | 科瑞特空调集团有限公司 | Air sterilizing and purifying device |
| CN116481118B (en) * | 2023-06-20 | 2023-08-22 | 科瑞特空调集团有限公司 | Air sterilizing and purifying device |
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| CN106942269B (en) | 2019-09-17 |
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