CN106938124A - The slow material of neutron - Google Patents
The slow material of neutron Download PDFInfo
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- CN106938124A CN106938124A CN201610004784.4A CN201610004784A CN106938124A CN 106938124 A CN106938124 A CN 106938124A CN 201610004784 A CN201610004784 A CN 201610004784A CN 106938124 A CN106938124 A CN 106938124A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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Abstract
The present invention discloses a kind of slow material of neutron, the slow material of neutron by the material containing lithium and it is a kind of have that fast neutron action section is big and the small material of epithermal neutron action section is constituted, the slow materials application of neutron is used as slow body in the beam-shaping body of neutron capture therapeutic system.The beneficial effects of the invention are as follows by adding the material containing lithium to improve by the prosthese beam quality of the slow neutron beam of the slow material of the neutron into the conventional slow material of neutron.
Description
Technical field
The present invention relates to a kind of slow material of radioactive ray, especially a kind of slow material of neutron.
Background technology
The slow material of neutron is common in the beam-shaping body of neutron capture therapeutic system, to power spectrum that will launch from neutron source compared with
Wide neutron beam is adjusted to the neutron beam with certain energy range, in the mistake treated using neutron capture therapeutic system
Cheng Zhong, influence therapeutic effect not only has air beam quality, in addition it is also necessary to consider prosthese beam quality.Not yet find to be directed at present
Screening of the prosthese beam quality of neutron beam to the slow material of neutron.
The content of the invention
During being treated using neutron capture therapeutic system, the prosthese beam quality of the neutron capture therapeutic system is determined
Determine therapeutic effect, wherein, the slow material of neutron for constituting slow body in the neutron capture therapeutic system is influence prosthese beam
The principal element of quality.The prosthese beam quality includes：Effective therapeutic depth, effective therapeutic depth close rate and effectively treatment
Dose ratio, wherein：
Effective therapeutic depth (AD) refer to tumor dose be equal to normal structure maximum dose depth, the position after this depth,
The dosage that tumour cell is obtained is less than normal structure maximum dose, that is, loses the advantage of boron neutron capture.This parameter represents neutron
The penetration capacity of beam, effective therapeutic depth is bigger to represent that medicable tumor depth is deeper, and unit is cm.
Effective therapeutic depth close rate is the tumor dose rate of effective therapeutic depth, also equal to the maximum dose rate of normal structure.Cause
Normal structure receives accumulated dose can give the factor of tumour accumulated dose size for influence, therefore parameter influences the length for the treatment of time,
Irradiation time needed for tumour doses are given in the bigger expression of effective therapeutic depth close rate is shorter, and unit is cGy/mA-min.
Dose therapeutically effective ratio refers to from brain surface to effective therapeutic depth, the mean dose ratio that tumour and normal structure are received,
Referred to as dose therapeutically effective ratio；The calculating of mean dose.Dose therapeutically effective ratio is bigger, represents the treatment of the neutron beam
Benefit is better.
The radiation field of neutron capture therapeutic system is mixing field, because photon, neutron can cause biological effect different, so being directed to
Fast neutron, thermal neutron and photon doses, are multiplied by the relative biological effect (RBE) of different tissues in the hope of equivalent agent respectively
Amount.Find that 30RBE-Gy can effective tumors destroyed cell during being treated using neutron capture therapeutic system.
Depth is to evaluate penetrating by the slow material of neutron where preferably effective therapeutic depth (AD) and tumour 30RBE-Gy of the invention
The prosthese beam quality of beam.
In order that having preferable prosthese beam quality by the slow neutron beam of the slow material of neutron, the invention provides in one kind
Sub slow material, the slow material of neutron has fast neutron action section big by the material containing lithium and one kind and epithermal neutron is acted on
The small material composition in section, wherein the weight of the material containing lithium accounts for the 5%~40% of the slow material weight of neutron.
Wherein, fast neutron of the present invention is more than 40keV neutron for energy area, and epithermal neutron energy area is in 0.5eV to 40keV
Between, subzone is hankered less than 0.5eV.
The material have fast neutron action section big and the small property of epithermal neutron action section by constituting the element of the material
Determined, when the one or more of elements for constituting the material have that fast neutron action section is big and epithermal neutron action section is small
Property when, the material has fast neutron action section big and the small property of epithermal neutron action section, it is common have it is fast in
Sub- action section is big and the small element of epithermal neutron action section includes but is not limited to：F, Al, Mg, O, Pb, Ba and Ca,
These elements are resonance zone in the action section of fast neutron energy range, these elements and the other elements phase for constituting the material
Interaction has higher neutron action section in fast neutron energy range to reach.
Preferably, in the slow material of the neutron, described have that fast neutron action section is big and epithermal neutron action section is small
Material includes：Al2O3、BaF2、CaF2、(C2F4)n、PbF2、PbF4。
Preferably, in the slow material of the neutron, the material containing lithium includes but is not limited to LiF, Li2CO3, wherein Li members
Element has the effect that thermal neutrons are absorbed with other described material competitions, gamma-ray content in neutron beam can be reduced, in this hair
In bright, the mutual cooperation effect in the material and material containing lithium between the content and element of various elements makes slow by the neutron
The slow neutron beam of material has preferable prosthese beam quality.Li elements described herein be preferably natural content Li (6Li
With7Li), certain those skilled in the art can also be used containing different content6Li。
Preferably, in the slow material of the neutron, have that fast neutron action section is big and epithermal neutron action section is small when described
Material be BaF2When, the weight of the material containing lithium accounts for the 25%~40% of the slow material weight of neutron, in the slow material of such neutron
Under the conditions of the composition of material, it is more than or equal to by depth where the tumour 30RBE-Gy of the neutron beam of the slow material of the neutron
By 1.92 times of the slow material of neutron without the material containing lithium；Have fast neutron action section big and epithermal neutron work when described
It is CaF with the small material in section2When, the weight of the material containing lithium accounts for the 35%~40% of the slow material weight of neutron, in such
It is big by depth where the tumour 30RBE-Gy of the neutron beam of the slow material of the neutron under the conditions of the composition of sub slow material
In or equal to by 1.01 times of the slow material of neutron without the material containing lithium；When described there is fast neutron action section to surpass greatly
The small material of thermal neutron action section is (C2F4)nWhen, the weight of the material containing lithium accounts for the 15%~20% of the slow material weight of neutron,
Under the conditions of the composition of the slow material of such neutron, by the tumour 30RBE-Gy of the neutron beam of the slow material of the neutron
Place depth is more than or equal to 1.01 times by the slow material of neutron without the material containing lithium；There is fast neutron effect when described
Section is big and the small material of epithermal neutron action section is PbF2When, the weight of the material containing lithium accounts for the slow material weight of neutron
25%~40%, under the conditions of the composition of the slow material of such neutron, by the slow material of the neutron neutron beam it is swollen
Depth is more than or equal to 1.11 times by the slow material of neutron without the material containing lithium where knurl 30RBE-Gy；When the tool
There is fast neutron action section big and the small material of epithermal neutron action section is PbF4When, the weight of the material containing lithium accounts for the slow material of neutron
The 15%~40% of weight is expected, under the conditions of the composition of the slow material of such neutron, by the neutron of the slow material of the neutron
Depth is more than or equal to 1.04 times by the slow material of neutron without the material containing lithium where the tumour 30RBE-Gy of beam；
Have that fast neutron action section is big and the small material of epithermal neutron action section is Al when described2O3When, the weight of the material containing lithium is accounted for
The 25% of the slow material weight of neutron, under the conditions of the composition of the slow material of such neutron, by the slow material of the neutron
Depth is more than or equal to 1.03 by the slow material of neutron without the material containing lithium where the tumour 30RBE-Gy of neutron beam
Times.
Preferably, in the slow material of the neutron, the slow material of neutron is to be laminated or mixed-powder pressed compact or mixed-powder
The form of sintering is arranged in beam-shaping body using the slow body as the beam-shaping body.
The slow density of material of neutron for wherein constituting the slow body is smaller, and the volume of slow body and the beam-shaping body is bigger,
Preferably, in the slow material of the neutron, the density of the slow material of neutron is 60%~100% solid density.
Preferably, in the slow material of the neutron, the beam-shaping body also include surrounding the reflector of the slow body, with
The thermal neutron absorber of the slow body adjoining and the radiation shield being arranged in the beam-shaping body.
Preferably, in the slow material of the neutron, the beam-shaping body is used for accelerator neutron capture therapeutic system, described
Accelerator neutron capture therapeutic system is including accelerator, the charged particle beam accelerated by the accelerator, for by described powered
The charged particle beam entrance of the particle beams, through with the charged particle beam occur nuclear reaction so as to produce neutron beam neutron generating unit,
For adjusting the beam-shaping body of the neutron beam flux produced through the neutron generating unit and quality and being adjacent to the beam-shaping
The beam outlet of body, wherein, the neutron generating unit is contained in the beam-shaping body.
Preferably, in the slow material of the neutron, the slow body is arranged to include at least one cone-shaped shape.
Preferably, in the slow material of the neutron, it is cone-shaped that the slow body is arranged to that two opposite directions adjoin each other.
Brief description of the drawings
Fig. 1 is19The neutron action section figure of F elements.
Fig. 2 is27The neutron action section figure of Al elements.
Fig. 3 is24The neutron action section figure of Mg elements.
Fig. 4 is16The neutron action section figure of O elements.
Fig. 5 is208The neutron action section figure of Pb elements.
Fig. 6 is138The neutron action section figure of Ba elements.
Fig. 7 is40The neutron action section figure of Ca elements.
Fig. 8 is accelerator formula neutron capture therapeutic system schematic diagram.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, with make those skilled in the art with reference to specification word can
Implement according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein be not precluded from it is one or more of the other into
Point or its combination presence or addition.
Fig. 1~Fig. 7 lists the neutron action section of 7 kinds of elements respectively, and some of which element includes more than one isotope, these yuan
Although the neutron action section slightly difference of element and its isotope, the shape of their neutron action section collection of illustrative plates is substantially
Consistent (action section in epithermal neutron region is smaller, and is rendered as resonance zone in fast region).
Illustrate beneficial effects of the present invention with contrast test by the following examples, wherein, embodiment and contrast test are to be based on
What tests below condition was completed：Prosthese uses Modified Snyder head phantom, and prosthese beam quality uses MCNP softwares
(being developed by Los Alamos National Laboratories of the U.S. based on DSMC) is calculated, the system of the slow material of neutron
Preparation Method is sinters after well mixed, and the density of the slow material of neutron is by described in solid density, the embodiment of the present invention
The geometry for the slow body that sub slow material is constituted is cone-shaped (as shown in Figure 8) that two opposite directions adjoin each other, wherein
The depth that neutron generating unit stretches into left side cone is 10cm, and the distance that neutron generating unit to beam is exported is 24cm, two cone weights
The radius in folded face is 40cm.
The experimental condition used above is simply to illustrate that beneficial effects of the present invention, those skilled in the art know ground, the present invention
Implementation condition be not limited to the experiment condition of the embodiment of the present invention.
<Embodiment 1>
Al2O3With the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
Al2O3For the contrast test of the embodiment, the prosthese beam product of the embodiment and contrast test are calculated by MCNP softwares
Matter is as shown in table 1.
Table 1：To contain Al2O3The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 2>
BaF2With the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
BaF2For the contrast test of the embodiment, the prosthese beam quality of the embodiment and contrast test is calculated by MCNP softwares
As shown in table 2.
Table 2：To contain BaF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 3>
CaF2With the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
CaF2For the contrast test of the embodiment, the prosthese beam quality of the embodiment and contrast test is calculated by MCNP softwares
As shown in table 3.
Table 3：To contain CaF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 4>
(C2F4)nWith the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
(C2F4)nFor the contrast test of the embodiment, the prosthese beam product of the embodiment and contrast test are calculated by MCNP softwares
Matter is as shown in table 4.
Table 4：To contain (C2F4)nThe slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 5>
PbF2With the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
PbF2For the contrast test of the embodiment, the prosthese beam quality of the embodiment and contrast test is calculated by MCNP softwares
As shown in table 5.
Table 5：To contain PbF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 6>
PbF4With the fast neutron action section small property of epithermal neutron action section greatly, with without any material containing Li
PbF4For the contrast test of the embodiment, the prosthese beam quality of the embodiment and contrast test is calculated by MCNP softwares
As shown in table 6.
Table 6：To contain PbF4The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 7>
The present embodiment is with Li2CO3Substitute<Embodiment 1>In LiF, remaining experiment condition and<Embodiment 1>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 7.
Table 7：To contain Al2O3The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 8>
The present embodiment is with Li2CO3Substitute<Embodiment 2>In LiF, remaining experiment condition and<Embodiment 2>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 8.
Table 8：To contain BaF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 9>
The present embodiment is with Li2CO3Substitute<Embodiment 3>In LiF, remaining experiment condition and<Embodiment 3>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 9.
Table 9：To contain CaF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 10>
The present embodiment is with Li2CO3Substitute<Embodiment 4>In LiF, remaining experiment condition and<Embodiment 4>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 10.
Table 10：To contain (C2F4)nThe slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 11>
The present embodiment is with Li2CO3Substitute<Embodiment 5>In LiF, remaining experiment condition and<Embodiment 5>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 11.
Table 11：To contain PbF2The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
<Embodiment 12>
The present embodiment is with Li2CO3Substitute<Embodiment 6>In LiF, remaining experiment condition and<Embodiment 6>In experiment bar
Part is identical, and the prosthese beam quality for calculating the embodiment and contrast test by MCNP softwares is as shown in table 12.
Table 12：To contain PbF4The slow material of neutron as the neutron capture therapeutic system of slow body prosthese beam quality
According to<Embodiment 1>Arrive<Embodiment 12>And its corresponding contrast test can be drawn：The addition of the material containing lithium can make
The slow material of neutron depth where it can be effectively improved tumour 30RBE-Gy on the premise of not slackening effective therapeutic depth.
Contrast<Embodiment 1>Arrive<Embodiment 7>With<Embodiment 8>Arrive<Embodiment 12>It can draw, add different containing lithium
Material can be effectively improved depth where tumour 30RBE-Gy.
The slow materials application of neutron is used as slow body 24, institute in accelerator formula neutron capture therapeutic system as shown in Figure 8
Accelerator formula neutron capture therapeutic system is stated including accelerator 10, the charged particle beam 11 accelerated by the accelerator, for passing through
The charged particle beam entrance 23 of the charged particle beam 11, through occurring nuclear reaction with the charged particle beam 11 so as to producing neutron
The neutron generating unit 22 of beam, the beam-shaping for adjusting the neutron beam flux produced through the neutron generating unit 22 and quality
Body 20 and the beam outlet 25 for being adjacent to the beam-shaping body, wherein, it is whole that the neutron generating unit 22 is contained in the beam
In body 20；The reflector 21 and the slow body 24 that wherein beam-shaping body 20 also includes surrounding the slow body 24 are adjacent
The thermal neutron absorber 26 connect and the radiation shield 27 being arranged in the beam-shaping body 20.
Wherein, slow body 24 is arranged to cone-shaped, the as shown in Figure 8 direction that two opposite directions adjoin each other, slow body
24 left side be towards left side taper into it is cone-shaped, the right side of slow body 24 be towards right side taper into it is cone-shaped,
Both adjoin each other.Reflector 21 is closely enclosed in around slow body 24, is set between slow body 24 and reflector 21
There is clearance channel 28, so-called clearance channel 28 refers to the empty area for easily allowing neutron beam to pass through of unused solid material covering
Domain, such as clearance channel 28 could be arranged to air duct or vacuum passage.The neutron absorption set close to slow body 24
Body 26 is by very thin one layer6Li materials are made, and the photon being made up of the Pb shielding in radiation shield 27 can be with reflector 21
Setting is integrated, and can also be arranged to split.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed utilization.
It can be applied to various suitable the field of the invention completely.For those skilled in the art, it is easily achieved another
Outer modification.Therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited to specifically
Details and shown here as the legend with description.
Claims (10)
1. a kind of slow material of neutron, it is characterised in that the slow material of neutron by the material containing lithium and one kind there is fast neutron to act on
The section small material composition of epithermal neutron action section greatly, wherein the weight of the material containing lithium accounts for the slow material weight of neutron
The 5%~40% of amount.
2. the slow material of neutron according to claim 1, it is characterised in that described have the fast neutron action section big and superthermal
The small material of sub- action section includes：Al2O3、BaF2、CaF2、(C2F4)n、PbF2、PbF4。
3. the slow material of neutron according to claim 1, it is characterised in that the material containing lithium includes LiF, Li2CO3。
4. the slow material of neutron according to any one of claim 1-3, it is characterised in that when described there is fast neutron effect to cut
Face is big and the small material of epithermal neutron action section is BaF2When, the weight of the material containing lithium accounts for the slow material weight of neutron
25%~40%；Have that fast neutron action section is big and the small material of epithermal neutron action section is CaF when described2When, containing lithium
The weight of material accounts for the 35%~40% of the slow material weight of neutron；Have fast neutron action section big and epithermal neutron when described
The small material of action section is (C2F4)nWhen, the weight of the material containing lithium accounts for the 15%~20% of the slow material weight of neutron；Work as institute
State big and the small material of epithermal neutron action section is PbF with fast neutron action section2When, during the weight of the material containing lithium is accounted for
The 25%~40% of sub slow material weight.；Have that fast neutron action section is big and epithermal neutron action section is small when described
Material is PbF4When, the weight of the material containing lithium accounts for the 15%~40% of the slow material weight of neutron.；There is fast neutron when described
Action section is big and the small material of epithermal neutron action section is Al2O3When, the weight of the material containing lithium accounts for the slow material weight of neutron
The 25% of amount.
5. the slow material of neutron according to any one of claim 1-3, it is characterised in that the density of the slow material of neutron
For 60%~100% solid density.
6. the slow material of neutron according to any one of claim 1-3, it is characterised in that the slow material of neutron is to be laminated
Or the form of mixed-powder pressed compact or mixed-powder sintering is arranged in beam-shaping body to be used as the slow of the beam-shaping body
Fast body.
7. the slow material of neutron according to claim 6, it is characterised in that the beam-shaping body also includes surrounding described slow
The reflector of body, the thermal neutron absorber with the slow body adjoining and the radiation shield being arranged in the beam-shaping body.
8. the slow material of neutron as claimed in claim 7, it is characterised in that the beam-shaping body is controlled for accelerator neutron capture
Device is treated, the accelerator neutron capture therapeutic system includes accelerator, the charged particle beam accelerated by the accelerator, use
In the charged particle beam entrance by the charged particle beam, through occurring nuclear reaction with the charged particle beam so as to produce neutron
The neutron generating unit of beam, for adjust through the neutron generating unit produce neutron beam flux and quality beam-shaping body and
The beam outlet of the beam-shaping body is adjacent to, wherein, the neutron generating unit is contained in the beam-shaping body.
9. the slow material of neutron according to claim 6, it is characterised in that the slow body is arranged to include at least one cone
The shape of shape.
10. the slow material of neutron according to claim 9, it is characterised in that the slow body is arranged to two opposite directions
What is adjoined each other is cone-shaped.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019034043A1 (en) * | 2017-08-18 | 2019-02-21 | 南京中硼联康医疗科技有限公司 | Moderator for moderating neutrons |
| CN116375473A (en) * | 2023-03-30 | 2023-07-04 | 山东亚赛陶瓷科技有限公司 | Magnesium fluoride-based composite neutron moderating material and preparation method thereof |
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| CN110507914A (en) | 2019-11-29 |
| CN110507914B (en) | 2021-05-07 |
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