CN106934253B - 用于基于网络的生物活动评价的系统和方法 - Google Patents

用于基于网络的生物活动评价的系统和方法 Download PDF

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CN106934253B
CN106934253B CN201710175969.6A CN201710175969A CN106934253B CN 106934253 B CN106934253 B CN 106934253B CN 201710175969 A CN201710175969 A CN 201710175969A CN 106934253 B CN106934253 B CN 106934253B
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CN106934253A (zh
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J·霍恩格
F·马丁
M·派奇
A·塞沃尔
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CN201710175969.6A 2011-06-10 2012-06-11 用于基于网络的生物活动评价的系统和方法 Expired - Fee Related CN106934253B (zh)

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US201161495824P 2011-06-10 2011-06-10
US61/495,824 2011-06-10
US201161525700P 2011-08-19 2011-08-19
US61/525,700 2011-08-19
EP11195417.8A EP2608122A1 (en) 2011-12-22 2011-12-22 Systems and methods for quantifying the impact of biological perturbations
EP11195417.8 2011-12-22
CN201280028435.6A CN103827896B (zh) 2011-06-10 2012-06-11 用于基于网络的生物活动评价的系统和方法

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CN201280028438.XA Expired - Fee Related CN103765448B (zh) 2011-06-10 2012-06-11 用于量化生物扰动的影响的系统和方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI746381B (zh) 2021-02-25 2021-11-11 長庚醫療財團法人高雄長庚紀念醫院 利用深度學習分析眼振感測資料的方法及眼振感測分析系統

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2608122A1 (en) 2011-12-22 2013-06-26 Philip Morris Products S.A. Systems and methods for quantifying the impact of biological perturbations
US8818920B2 (en) * 2012-03-09 2014-08-26 Bank Of America Corporation Incremental effect modeling by area index maximization
CN104737167B (zh) * 2012-10-22 2019-01-04 起元科技有限公司 使用源跟踪剖析数据
US8554712B1 (en) 2012-12-17 2013-10-08 Arrapoi, Inc. Simplified method of predicting a time-dependent response of a component of a system to an input into the system
JP6372892B2 (ja) * 2012-12-28 2018-08-15 セルベンタ インコーポレイテッド 機構的ネットワークモデルを使用した生物学的影響の定量評価
US9253044B1 (en) * 2013-01-04 2016-02-02 Selventa, Inc. Quantitative assessment of biological impact using overlap methods
CA2910061C (en) * 2013-04-23 2023-08-15 Philip Morris Products S.A. Systems and methods for using mechanistic network models in systems toxicology
EP3033721A1 (en) * 2013-08-12 2016-06-22 Philip Morris Products S.A. Systems and methods for crowd-verification of biological networks
EP3044713A1 (en) 2013-09-13 2016-07-20 Philip Morris Products S.A. Systems and methods for evaluating perturbation of xenobiotic metabolism
US12020823B2 (en) * 2013-11-01 2024-06-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. Integrated virtual patient framework
US9430739B2 (en) 2013-12-19 2016-08-30 Praedicat, Inc. Determining general causation from processing scientific articles
GB201405243D0 (en) 2014-03-24 2014-05-07 Synthace Ltd System and apparatus 1
EP4708152A3 (en) * 2014-06-30 2026-04-29 Evolving Machine Intelligence Pty Ltd A system and method for modelling system behaviour
US10309956B2 (en) 2014-07-10 2019-06-04 R.J. Reynolds Tobacco Company Process for assessing risk of substance administration
AR101678A1 (es) * 2014-09-11 2017-01-04 Sony Corp Dispositivo de procesamiento de información, método de procesamiento de información y medio de almacenamiento legible por computadora no transitorio de almacenamiento de programa
US20160092653A1 (en) * 2014-09-30 2016-03-31 Koninklijke Philips N.V. NUTRITIONAL INTAKE VIEWER (NutriWeb)
US12053292B2 (en) * 2014-12-05 2024-08-06 Lifecycle Technologies Pty Ltd. Method and system for improving a physiological response
US9762393B2 (en) * 2015-03-19 2017-09-12 Conduent Business Services, Llc One-to-many matching with application to efficient privacy-preserving re-identification
GB201511587D0 (en) * 2015-07-02 2015-08-19 Ge Healthcare Bio Sciences Ab A method and a system for determining a concentration range for a sample by means of a calibration curve
US10529253B2 (en) * 2016-08-30 2020-01-07 Bernard De Bono Method for organizing information and generating images of biological structures as well as related resources and the images and materials so generated
US20190318802A1 (en) * 2016-10-13 2019-10-17 University Of Florida Research Foundation, Incorporated Method and apparatus for improved determination of node influence in a network
US12619852B2 (en) 2017-01-27 2026-05-05 Ohuku Llc Method and system for simulating, predicting, interpreting, comparing, or visualizing complex data
WO2018203349A1 (en) * 2017-05-01 2018-11-08 Parag Kulkarni A system and method for reverse hypothesis machine learning
CA3057420C (en) * 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
US10657179B2 (en) * 2017-09-01 2020-05-19 X Development Llc Bipartite graph structure
US11024403B2 (en) * 2018-01-22 2021-06-01 X Development Llc Method for analyzing and optimizing metabolic networks
US11068540B2 (en) 2018-01-25 2021-07-20 Ab Initio Technology Llc Techniques for integrating validation results in data profiling and related systems and methods
US11309058B2 (en) 2018-03-30 2022-04-19 X Development Llc Modeling the chemical composition of a biological cell wall
CN108614536B (zh) * 2018-06-11 2020-10-27 云南中烟工业有限责任公司 一种卷烟制丝工艺关键因素的复杂网络构建方法
US10961921B2 (en) 2018-09-19 2021-03-30 Pratt & Whitney Canada Corp. Model-based control system and method for a turboprop engine
US11521710B2 (en) * 2018-10-31 2022-12-06 Tempus Labs, Inc. User interface, system, and method for cohort analysis
CN109521172A (zh) * 2018-11-14 2019-03-26 苏州新派特信息科技有限公司 一种采用扁螺防控红丝虫的生物扰动效应的模拟方法
CN109712667A (zh) * 2018-12-28 2019-05-03 广东省心血管病研究所 模拟骨髓间充质干细胞移植体外模型构建中的控制方法
CA3127607A1 (en) * 2019-01-23 2020-07-30 The Regents Of The University Of Michigan Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors
US10585990B1 (en) 2019-03-15 2020-03-10 Praedicat, Inc. Live updating visualization of causation scores based on scientific article metadata
EP3799057A1 (en) * 2019-09-25 2021-03-31 Koninklijke Philips N.V. Prediction tool for patient immune response to a therapy
CN110729022B (zh) * 2019-10-24 2023-06-23 江西中烟工业有限责任公司 一种被动吸烟大鼠早期肝损伤模型建立方法及相关基因筛选方法
CN111223520B (zh) * 2019-11-20 2023-09-12 云南省烟草农业科学研究院 一种预测烟草尼古丁含量的全基因组选择模型及其应用
US10748091B1 (en) 2020-01-16 2020-08-18 Applied Underwriters, Inc. Forecasting digital reservoir controller
CN111755065B (zh) * 2020-06-15 2024-05-17 重庆邮电大学 一种基于虚拟网络映射和云并行计算的蛋白质构象预测加速方法
WO2023058056A1 (en) * 2021-10-05 2023-04-13 Vishal Gupta A system for entity state-based stage-wise formal specification of processes and a method therefor
US11954159B2 (en) * 2021-11-09 2024-04-09 Adp, Inc. System and method for using graph theory to rank characteristics
US12620459B2 (en) 2022-02-16 2026-05-05 Stokely-Van Camp, Inc. High efficacy functional ingredient blends
CN114821823B (zh) * 2022-04-12 2023-07-25 马上消费金融股份有限公司 图像处理、人脸防伪模型的训练及活体检测方法和装置
JP2023161401A (ja) * 2022-04-25 2023-11-07 国立研究開発法人農業・食品産業技術総合研究機構 形質予測方法、形質予測モデル生成方法、形質予測装置、形質予測モデル生成装置、及び形質予測システム
CN116453585B (zh) * 2023-02-23 2025-08-12 中南大学 mRNA和药物关联的预测方法、装置、终端设备及介质

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5640494A (en) * 1991-03-28 1997-06-17 The University Of Sydney Neural network with training by perturbation
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
IL134994A0 (en) * 2000-03-09 2001-05-20 Yeda Res & Dev Coupled two way clustering analysis of data
US7623969B2 (en) * 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
US20070016390A1 (en) * 2002-03-06 2007-01-18 Bernardo Diego D Systems and methods for reverse engineering models of biological networks
WO2005055113A2 (en) * 2003-11-26 2005-06-16 Genstruct, Inc. System, method and apparatus for causal implication analysis in biological networks
US7376520B2 (en) * 2005-03-16 2008-05-20 Lam Research Corporation System and method for gas flow verification
US20070225956A1 (en) * 2006-03-27 2007-09-27 Dexter Roydon Pratt Causal analysis in complex biological systems
US20080195322A1 (en) * 2007-02-12 2008-08-14 The Board Of Regents Of The University Of Texas System Quantification of the Effects of Perturbations on Biological Samples
WO2008124096A1 (en) * 2007-04-04 2008-10-16 Gaia Medical Institute Systems and methods for analyzing persistent homeostatic perturbations
US8068994B2 (en) * 2007-07-27 2011-11-29 Wayne State University Method for analyzing biological networks
WO2009042754A1 (en) 2007-09-26 2009-04-02 Genstruct, Inc. Software assisted methods for probing the biochemical basis of biological states
WO2009132239A2 (en) * 2008-04-24 2009-10-29 Trustees Of Boston University A network biology approach for identifying targets for combination therapies
WO2009155009A1 (en) * 2008-05-27 2009-12-23 Memorial Sloan Kettering Cancer Center Models for combinatorial perturbations of living biological systems
US20110191087A1 (en) * 2008-09-03 2011-08-04 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Computer implemented model of biological networks
US20100299289A1 (en) * 2009-05-20 2010-11-25 The George Washington University System and method for obtaining information about biological networks using a logic based approach
EP2514361A1 (en) * 2011-04-22 2012-10-24 Université Catholique De Louvain In vivo quantification of a variation of oxygenation in a tissue by using a magnetic resonance imaging technique
EP2608122A1 (en) 2011-12-22 2013-06-26 Philip Morris Products S.A. Systems and methods for quantifying the impact of biological perturbations
CN107391961B (zh) 2011-09-09 2020-11-17 菲利普莫里斯生产公司 用于基于网络的生物活性评估的系统与方法
CA2910061C (en) 2013-04-23 2023-08-15 Philip Morris Products S.A. Systems and methods for using mechanistic network models in systems toxicology

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Anonymous:"Reverse Causal Reasoning Method - White Paper";Selventa.com;《http://www.selventa.com/attachments/white_papers/reverse-causal-reasoning.pdf》;20110204;全文 *
Patricia Gimenez:" Local Influence Analysis Based on the Perturbation Manifold in functional Measurement Error Models";Congreso Monteiro;《http://www.matematica.uns.edu.ar/XCongresomonteiro/actas.HTM》;20090529;全文 *
Selventa.com.Anonymous:"Reverse Causal Reasoning Method - White Paper".《http://www.selventa.com/attachments/white_papers/reverse-causal-reasoning.pdf》.2011, *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI746381B (zh) 2021-02-25 2021-11-11 長庚醫療財團法人高雄長庚紀念醫院 利用深度學習分析眼振感測資料的方法及眼振感測分析系統

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JP6138768B2 (ja) 2017-05-31
WO2012168483A1 (en) 2012-12-13
CN103827896A (zh) 2014-05-28
JP2014522531A (ja) 2014-09-04
JP6335260B2 (ja) 2018-05-30
EP2718880A1 (en) 2014-04-16
US10916350B2 (en) 2021-02-09
EP2718879A1 (en) 2014-04-16
US9558318B2 (en) 2017-01-31
CN106940758B (zh) 2019-10-11
US20140172398A1 (en) 2014-06-19
EP2608122A1 (en) 2013-06-26
US20170235914A1 (en) 2017-08-17
JP2018120617A (ja) 2018-08-02
WO2012168481A1 (en) 2012-12-13
CN103765448A (zh) 2014-04-30
JP2017073160A (ja) 2017-04-13
CN103827896B (zh) 2017-04-26
JP2017073161A (ja) 2017-04-13
JP2014522530A (ja) 2014-09-04
US20140114987A1 (en) 2014-04-24
CN103765448B (zh) 2017-05-17
JP6336020B2 (ja) 2018-06-06
CN106940758A (zh) 2017-07-11
CN106934253A (zh) 2017-07-07
JP6138767B2 (ja) 2017-05-31

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