CN106929722A - Degradable Mg La Fe alloy materials that a kind of detachment blood vessel is plugged into and its preparation method and application - Google Patents

Degradable Mg La Fe alloy materials that a kind of detachment blood vessel is plugged into and its preparation method and application Download PDF

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Publication number
CN106929722A
CN106929722A CN201710117932.8A CN201710117932A CN106929722A CN 106929722 A CN106929722 A CN 106929722A CN 201710117932 A CN201710117932 A CN 201710117932A CN 106929722 A CN106929722 A CN 106929722A
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blood vessel
powder
mixed
degradable
alloy materials
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滑有录
李扬德
李卫荣
李卫
何东磊
刘芳菲
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Dongguan Eontec Co Ltd
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Dongguan Eontec Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A61L17/145—Coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C22C1/0408—Light metal alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C23/00—Alloys based on magnesium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • B22F2003/145—Both compacting and sintering simultaneously by warm compacting, below debindering temperature

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses the degradable Mg La Fe alloy materials that a kind of detachment blood vessel is plugged into, including Mg, La and Fe element, specifically including following component in percentage by weight：0.05 0.15%La；0.5 3.2%Fe；Other impurity content≤0.005%；Balance of Mg.On this basis, blood vessel anastomat is also prepared using the Mg La Fe alloy materials, and its surface is modified, i.e., adsorb polyglycolic acid film in its surfaces externally and internally.At detachment blood vessel end, termination was refuted in the reparation phase, and the film gradually degraded can provide the microenvironment of endangium growth, contributed to impaired or detachment blood vessel quickly to plug into.Detachment blood vessel is plugged into after the completion of reparation, and the time that blood vessel anastomat is retained in vivo is more short better, and the Mg La Fe alloys that the present invention is provided possess fast degradation performance, not only can be degradable in a short time, and tolerate in vivo.

Description

Degradable Mg-La-Fe alloy materials and its preparation side that a kind of detachment blood vessel is plugged into Method and application
Technical field
The invention belongs to medical instruments field, it is related to degradable medical biomaterial, more particularly to a kind of detachment blood vessel to connect Degradable Mg-La-Fe alloy materials refuted and preparation method thereof, and using the vascular anastomosis of the Mg-La-Fe alloy materials Device and preparation method thereof.
Background technology
In the prior art, there are surgical operation, intervention support and drug therapy for the treatment means of vascular diseases.Clinically Most of blood vessel to detachment uses manual suture, the experienced surgical specialist of suturing skill requirement.Particularly suture small blood Guan Shi, may cause the time lengthening of operation, and with certain risk.Hence it is highly desirable to have a kind of safety, letter Single, quick vascular anastomosis method.
The content of the invention
In order to overcome the deficiencies in the prior art, first purpose of the invention is dropping of providing that detachment blood vessel plugs into Solution Mg-La-Fe alloy materials, are used as the raw material for preparing blood vessel connector, and effect of plugging into is good, and can be complete in a short time Degraded, it is nontoxic, it is safe to use；Tolerance in vivo simultaneously.
Second object of the present invention is to provide the degradable Mg-La-Fe alloy materials that detachment blood vessel is plugged into, step Few, process is simple, obtained good product quality and stabilization.
Third object of the present invention is to provide a kind of blood vessel anastomat (microcapillary of plugging into), and blood vessel effect of plugging into is good, And can be degradable in a short time, it is harmless, it is safe to use.
Fourth object of the present invention is to provide a kind of preparation method of blood vessel anastomat, and step is few, and flow is simple, institute Obtained good product quality and stabilization.
First purpose of the invention is realized using following technical scheme：
A kind of degradable Mg-La-Fe alloy materials that detachment blood vessel is plugged into, the alloy material includes Mg, La and Fe Element.
Preferably, the alloy material includes following component in percentage by weight：0.05-0.15%La；0.5- 3.2%Fe；Other impurity content≤0.005%；Balance of Mg.
Second object of the present invention is realized using following technical scheme：
A kind of preparation method of degradable Mg-La-Fe alloy materials, comprises the following steps：
1) Mg-La alloyed powders, Mg-Fe alloyed powders and Mg metal powders are taken respectively, is mixed, obtain the first mixed-powder；
2) first mixed-powder is well mixed, obtains the second mixed-powder；
3) second mixed-powder is carried out into hot pressed sintering, obtains final product the Mg-La-Fe alloy materials.
Preferably, in step 1) in, the particle diameter of the Mg-La alloyed powders, Mg-Fe alloyed powders and Mg metal powders is ≤0.2 μm；In step 2) in, powder is uniformly mixed under vacuum or argon gas protective condition, it is 150-300r/min, time to set mixed powder speed It is 20-60min, obtains the second mixed-powder.
Preferably, in step 3) in, the concrete operations of hot pressed sintering are as follows：
3-1) the second mixed-powder is put into the graphite jig of cylindrical shape, is subsequently placed into hot pressed sintering burner hearth；
Hot-pressed sintering furnace 3-2) is evacuated down to 3.67-5.0 × 10-3During Pa, then applying argon gas, until vacuometer shows 0.6-1Mpa；
3-3) heat, temperature reaches 780-820 DEG C, be incubated 0.4-1.0h；
3-4) pressurize, pressure is 100-500N, and pressing time is 0.5-1h；
3-5) furnace cooling, after temperature drops to room temperature, feeding obtains final product the Mg-La-Fe alloy materials.
Third object of the present invention is realized using following technical scheme：
A kind of blood vessel anastomat, is prepared from by described Mg-La-Fe alloy materials.
Preferably, the surfaces externally and internally of the blood vessel anastomat is provided with PVOH sorrel.
Fourth object of the present invention is realized using following technical scheme：
A kind of preparation method of blood vessel anastomat, is prepared using hot extrusion technique, and concrete operations are as follows：
1) hot-extrusion mold is installed and is positioned on the work top of vacuum heat extruder, after die trial is qualified, by Mg-La- Fe alloy extrusion samples are put into recipient；
2) vacuumized successively, heated, being incubated and pressurized operation after, proceed by extruding, extruding punch movement away from During from maximum, stop extruding, complete hot extrusion technique step；
3) heating, cooling are stopped；When extrusion temperature drops to room temperature, pickup obtains final product the blood vessel anastomat.
Preferably, in step 2) in, it is evacuated to 3.67-5.0 × 10-3Pa, be heated to 230-350 DEG C, insulation 0.5-1h, 300-500MPa is forced into, extruding is then proceeded by.
Preferably, in step 3) obtain blood vessel anastomat after, also including step 4) surface modification technology, concrete operations are such as Under：
4-1) take step 3) blood vessel anastomat that obtains, and is fixed on the workbench of plastic suction forming apparatus；
4-2) take particle diameter≤0.2 μm and be the polyglycolic acid powder of blown film level, be put into hopper, heating is until melt index is 2-6g/10min；Continue to heat, be warmed up to 160-200 DEG C, be incubated 10-20min, form molten polyglycolic acid；
4-3) start to extrude molten polyglycolic acid, extruded velocity 0.1mm/s, blowing traction, blow-up ratio is controlled in 1.5- 3.0 so that polyglycolic acid forms film and is adsorbed in the surfaces externally and internally of the blood vessel anastomat；
After 4-4) cooling down, degradable blood vessel anastomosis device of the surface with polyglycolic acid film is obtained final product.
Compared to existing technology, the beneficial effects of the present invention are：
(1) the degradable Mg-La-Fe alloy materials that detachment blood vessel provided by the present invention is plugged into, can be used for preparing Blood vessel is plugged into microcapillary (blood vessel anastomat), after blood vessel of plugging into, can be degradable in a short time, and it is harmless nontoxic, use peace Quan Xinggao；And it is possible to the surfaces externally and internally of microcapillary of being plugged into blood vessel is modified, that is, last layer polyglycolic acid film is adsorbed, Polyglycolic acid film contributes to impaired or detachment blood vessel to plug into, and is plugged into completely the good time period in human body damaged blood vessels tissue Interior, polyglycolic acid film can gradually degrade, and the remaining time in human body is short, greatly reduces medical-risk.
(2) blood vessel anastomat provided by the present invention, is prepared from using degradable mg-based material and polyglycolic acid, It is a kind of new blood vessel anastomat.Using polyglycolic acid as raw material, blood vessel microcapillary is carried out into surface and is modified, obtain one Kind of the blood vessel connector with film layer, the modified purpose in surface be polyglycolic acid when degraded, discharge CO2And H2O, is blood The cell growth of tube wall provides suitable microenvironment, promotes coincideing for detachment blood vessel two ends.When using, by the two ends of detachment blood vessel Be inserted into the modified microcapillary two ends in surface carry out vascular anastomosis be connected, realize end to end anastomosis.It is coincide compared to suture or is propped up Frame is put up a bridge and PCI, and blood vessel anastomat of the invention need not be sutured, simple to operate, quick, safety, and damage After vascular repair, implantation instrument can voluntarily degrade, and realize that temporary support is acted on.
Brief description of the drawings
The microscopic structure view of the Mg-La-Fe alloy materials that Fig. 1 is provided by the embodiment of the present invention 1；
The blood vessel anastomat being modified by surface that Fig. 2 is provided by the embodiment of the present invention 1；
The Mg-La-Fe alloy material corrosion degradation test result figures that Fig. 3 is provided by the embodiment of the present invention 1.
Specific embodiment
Below, with reference to accompanying drawing and specific embodiment, the present invention is described further：
Embodiment 1
A kind of blood vessel anastomat, is prepared from according to following steps successively：
1) 96.8%Mg-0.05%La-3.2%Fe alloys are prepared, is weighed and closed in the middle of the Mg-La that mass percent is 10% Gold, 20% Mg-Fe intermediate alloys and balance of Mg powder, wherein, powder diameter is 0.2 μm；
2) by three kinds of powder under vacuum or argon gas protective condition uniformly mixed powder (it is 150r/min to set mixed powder speed, when Between be 30min), obtain the mixed-powder containing Mg, La, Fe；
3) mixed-powder is put into the graphite jig of cylindrical shape, is subsequently placed into hot pressed sintering burner hearth；
4) hot-pressed sintering furnace is evacuated down to 4.0 × 10-3During Pa, then applying argon gas, until vacuometer display 0.8Mpa；
5) heat, temperature reaches 780 DEG C, be incubated 0.5h；
6) pressurize, pressure is 100N, pressing time 0.5h.
7) furnace cooling, after temperature drops to room temperature, feeding.
8) hot-extrusion mold is installed and is positioned on the work top of vacuum heat extruder, after die trial is qualified, by 96.8% Mg-0.05%La-3.2%Fe alloy extrusions sample (hollow bar) is put into recipient；
9) (3.67 × 10 are vacuumized successively-3Pa), heating (250 DEG C), insulation (0.5h) and pressurization 350MPa, start Extruded, when the distance of extruding punch movement is maximum, stopped extruding, completed hot extrusion technique step；
10) heating, cooling are stopped；When extrusion temperature drops to room temperature, pickup obtains final product microcapillary；
11) the modified polyglycolic acid powder used in surface is chosen, particle diameter is 0.2 μm；
12) microcapillary that will have been prepared, and be fixed on the workbench of plastic suction forming apparatus；
13) polyglycolic acid particles of blown film level are put into hopper, heating until melt index is 3g/10min；Continue to add Heat, is warmed up to 180 DEG C, is incubated 10min, forms molten polyglycolic acid；
14) start to extrude molten polyglycolic acid, extruded velocity 0.1mm/s, blowing traction, blow-up ratio is controlled 2.0, made Polyglycolic acid forms film and is adsorbed in blood vessel and plugs into the surfaces externally and internally of microcapillary；
15) after cooling down, degradable blood vessel anastomosis device of the surface with polyglycolic acid film is obtained final product.
As shown in figure 1, be step 7) acquired in Mg-La-Fe alloy materials microscopic structure view, can from figure Ash discharge dead color, bright color and black different phase compositions, learn through XRD diffraction test analysis：The alloy contains Mg17La2With Tiny Fe is evenly distributed on matrix.
As shown in Fig. 2 being the final blood vessel anastomat being modified by surface for obtaining, its a diameter of 2.221mm.
Embodiment 2
A kind of blood vessel anastomat, is prepared from according to following steps successively：
1) 97.1%Mg-0.1%La-2.8%Fe alloys are prepared, is weighed and closed in the middle of the Mg-La that mass percent is 15% Gold, 14% Mg-Fe intermediate alloys and balance of Mg powder, wherein, powder diameter is 0.15 μm；
2) by three kinds of powder under vacuum or argon gas protective condition uniformly mixed powder (it is 200r/min to set mixed powder speed, when Between be 40min), obtain the mixed-powder containing Mg, La, Fe；
3) mixed-powder is put into the graphite jig of cylindrical shape, is subsequently placed into hot pressed sintering burner hearth；
4) hot-pressed sintering furnace is evacuated down to 3.6 × 10-3During Pa, then applying argon gas, until vacuometer display 0.8Mpa；
5) heat, temperature reaches 800 DEG C, be incubated 0.4h；
6) pressurize, pressure is 100N, pressing time 0.5h；
7) furnace cooling, after temperature drops to room temperature, feeding；
8) hot-extrusion mold is installed and is positioned on the work top of vacuum heat extruder, after die trial is qualified, by 97.1% Mg-0.1%La-2.8%Fe alloy extrusions sample (hollow bar) is put into recipient；
9) (3.6 × 10 are vacuumized successively-3Pa), heating (300 DEG C), insulation (1h) and pressurize 400MPa, start into Row extruding, when the distance of extruding punch movement is maximum, stops extruding, completes hot extrusion technique step；
10) heating, cooling are stopped；When extrusion temperature drops to room temperature, pickup obtains final product microcapillary.
11) the modified polyglycolic acid powder used in surface, 0.1 μm of particle diameter are chosen；
12) microcapillary that will have been prepared, and be fixed on the workbench of plastic suction forming apparatus；
13) polyglycolic acid particles of blown film level are put into hopper, heating until melt index is 4g/10min；Continue to add Heat, is warmed up to 200 DEG C, is incubated 20min, forms molten polyglycolic acid；
14) start to extrude molten polyglycolic acid, extruded velocity 0.08mm/s, blowing traction, blow-up ratio is controlled 2.2, So that polyglycolic acid forms film and is adsorbed in blood vessel plugging into the surfaces externally and internally of microcapillary；
15) after cooling down, degradable blood vessel anastomosis device of the surface with polyglycolic acid film is obtained final product.
Embodiment 3
A kind of blood vessel anastomat, is prepared from according to following steps successively：
1) 98.85%Mg-0.15%La-1.0%Fe alloys are prepared, is weighed in the middle of the Mg-La that mass percent is 15% Alloy, 5% Mg-Fe intermediate alloys and balance of Mg powder, wherein, 0.1 μm of powder diameter；
2) by three kinds of powder under vacuum or argon gas protective condition uniformly mixed powder (it is 250r/min to set mixed powder speed, when Between be 50min), obtain the mixed-powder containing Mg, La, Fe；
3) mixed-powder is put into the graphite jig of cylindrical shape, is subsequently placed into hot pressed sintering burner hearth；
4) hot-pressed sintering furnace is evacuated down to 5.0 × 10-3During Pa, then applying argon gas, until vacuometer display 0.6Mpa；
5) heat, temperature reaches 820 DEG C, be incubated 1h；
6) pressurize, pressure is 500N, pressing time 1h；
7) furnace cooling, after temperature drops to room temperature, feeding；
8) hot-extrusion mold is installed and is positioned on the work top of vacuum heat extruder, after die trial is qualified, will 98.85Mg-0.15La-1.0Fe alloy extrusions sample (hollow bar) is put into recipient；
9) (4.0 × 10 are vacuumized successively-3Pa), heating (220 DEG C), insulation (0.5h) and pressurization 400MPa, start Extruded, when the distance of extruding punch movement is maximum, stopped extruding, completed hot extrusion technique step；
10) heating, cooling are stopped；When extrusion temperature drops to room temperature, pickup obtains final product microcapillary；
11) the modified polyglycolic acid powder used in surface, 0.1 μm of particle diameter are chosen；
12) microcapillary that will have been prepared, and be fixed on the workbench of plastic suction forming apparatus；
13) polyglycolic acid particles of blown film level are put into hopper, heating until melt index is 6g/10min；Continue to add Heat, is warmed up to 200 DEG C, is incubated 20min, forms molten polyglycolic acid；
14) start to extrude molten polyglycolic acid, extruded velocity 0.1mm/s, blowing traction, blow-up ratio is controlled 5.0, made Polyglycolic acid forms film and is adsorbed in blood vessel and plugs into the surfaces externally and internally of microcapillary；
15) after cooling down, degradable blood vessel anastomosis device of the surface with polyglycolic acid film is obtained final product.
Test case 1
The Mg-La-Fe alloy materials that Example 1 is obtained carry out corrosion degradation test, corrosion degradation velocity test foundation The qualitative and quantitative of the part metals of GBT 16886.15-2003 BiologicalEvaluationofMedicalDevices the 15th and alloy catabolite.Adopt Method is infusion method, and the sodium chloride physiological saline of corrosive liquid selection 0.9%, control group is pure magnesium.Corrosion degradation speed Test result is as shown in Figure 3.
From figure 3, it can be seen that after addition La, Fe alloying element, in the reduced time of 10 days, the degradation rule of pure magnesium It is first to increase to reduce afterwards, and Mg-La-Fe alloys are gradually to increase, main cause is caused by Fe so that blood vessel anastomat is planted Can be disappeared in a short time after entering.
The corrosion degradation test result and the class of embodiment 1 of the Mg-La-Fe alloy materials that embodiment 2 and embodiment 3 are obtained Seemingly, will not be repeated here.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various It is corresponding to change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention Within.

Claims (10)

1. the degradable Mg-La-Fe alloy materials that a kind of detachment blood vessel is plugged into, it is characterised in that the alloy material includes Mg, La and Fe element.
2. degradable Mg-La-Fe alloy materials according to claim 1, it is characterised in that the alloy material includes pressing According to the following component of percentage by weight meter：0.05-0.15%La；0.5-3.2%Fe；Other impurity content≤0.005%； Balance of Mg.
3. a kind of preparation method of degradable Mg-La-Fe alloy materials as described in claim 1-2 any one, its feature It is to comprise the following steps：
1) Mg-La alloyed powders, Mg-Fe alloyed powders and Mg metal powders are taken respectively, is mixed, obtain the first mixed-powder；
2) first mixed-powder is well mixed, obtains the second mixed-powder；
3) second mixed-powder is carried out into hot pressed sintering, obtains final product the Mg-La-Fe alloy materials.
4. the preparation method of degradable Mg-La-Fe alloy materials according to claim 3, it is characterised in that in step 1) In, the particle diameter of the Mg-La alloyed powders, Mg-Fe alloyed powders and Mg metal powders≤0.2 μm；
In step 2) in, powder is uniformly mixed under vacuum or argon gas protective condition, it is 150-300r/min, time to set mixed powder speed It is 20-60min, obtains the second mixed-powder.
5. the preparation method of degradable Mg-La-Fe alloy materials according to claim 3, it is characterised in that in step 3) In, the concrete operations of hot pressed sintering are as follows：
3-1) the second mixed-powder is put into the graphite jig of cylindrical shape, is subsequently placed into hot pressed sintering burner hearth；
Hot-pressed sintering furnace 3-2) is evacuated down to 3.67-5.0 × 10-3During Pa, then applying argon gas, until vacuometer display 0.6- 1Mpa；
3-3) heat, temperature reaches 780-820 DEG C, be incubated 0.4-1.0h；
3-4) pressurize, pressure is 100-500N, and pressing time is 0.5-1h；
3-5) furnace cooling, after temperature drops to room temperature, feeding obtains final product the Mg-La-Fe alloy materials.
6. a kind of blood vessel anastomat, it is characterised in that the Mg-La-Fe alloy material systems as described in claim 1-2 any one It is standby to form.
7. blood vessel anastomat according to claim 6, it is characterised in that the surfaces externally and internally of the blood vessel anastomat is respectively provided with There is PVOH sorrel.
8. a kind of preparation method of blood vessel anastomat as claimed in claim 6, it is characterised in that use hot extrusion technique system Standby, concrete operations are as follows：
1) hot-extrusion mold is installed and is positioned on the work top of vacuum heat extruder, after die trial is qualified, Mg-La-Fe closed Golden extruded sample is put into recipient；
2) vacuumized successively, heated, being incubated and pressurized operation after, proceed by extruding, the distance of extruding punch movement is most When big, stop extruding, complete hot extrusion technique step；
3) heating, cooling are stopped；When extrusion temperature drops to room temperature, pickup obtains final product the blood vessel anastomat.
9. the preparation method of blood vessel anastomat according to claim 8, it is characterised in that in step 2) in, it is evacuated to 3.67-5.0×10-3Pa, 230-350 DEG C is heated to, 0.5-1h is incubated, is forced into 300-500MPa, then proceeding by extruding.
10. the preparation method of blood vessel anastomat according to claim 8, it is characterised in that in step 3) obtain blood vessel kiss After clutch, also including step 4) surface modification technology, concrete operations are as follows：
4-1) take step 3) blood vessel anastomat that obtains, and is fixed on the workbench of plastic suction forming apparatus；
4-2) take particle diameter≤0.2 μm and be the polyglycolic acid powder of blown film level, be put into hopper, heating is until melt index is 2- 6g/10min；Continue to heat, be warmed up to 160-200 DEG C, be incubated 10-20min, form molten polyglycolic acid；
4-3) start to extrude molten polyglycolic acid, extruded velocity 0.1mm/s, blowing traction, blow-up ratio is controlled in 1.5-3.0, So that polyglycolic acid forms film and is adsorbed in the surfaces externally and internally of the blood vessel anastomat；
After 4-4) cooling down, degradable blood vessel anastomosis device of the surface with polyglycolic acid film is obtained final product.
CN201710117932.8A 2017-03-01 2017-03-01 Degradable Mg La Fe alloy materials that a kind of detachment blood vessel is plugged into and its preparation method and application Withdrawn CN106929722A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107557633A (en) * 2017-08-10 2018-01-09 北京航空航天大学 A kind of microalloying medical degradable magnesium alloy and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107557633A (en) * 2017-08-10 2018-01-09 北京航空航天大学 A kind of microalloying medical degradable magnesium alloy and preparation method thereof
CN107557633B (en) * 2017-08-10 2019-07-09 北京航空航天大学 A kind of microalloying medical degradable magnesium alloy and preparation method thereof

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