CN106925593A - A kind of method of antibiotic fermentation bacteria residue solidification dehydration - Google Patents
A kind of method of antibiotic fermentation bacteria residue solidification dehydration Download PDFInfo
- Publication number
- CN106925593A CN106925593A CN201511006120.3A CN201511006120A CN106925593A CN 106925593 A CN106925593 A CN 106925593A CN 201511006120 A CN201511006120 A CN 201511006120A CN 106925593 A CN106925593 A CN 106925593A
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- CN
- China
- Prior art keywords
- antibiotic
- bacteria residue
- solidification
- dehydration
- fermentation
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- 241000894006 Bacteria Species 0.000 title claims abstract description 131
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 80
- 238000000855 fermentation Methods 0.000 title claims abstract description 77
- 230000004151 fermentation Effects 0.000 title claims abstract description 76
- 238000007711 solidification Methods 0.000 title claims abstract description 59
- 230000008023 solidification Effects 0.000 title claims abstract description 59
- 230000018044 dehydration Effects 0.000 title claims abstract description 52
- 238000006297 dehydration reaction Methods 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims abstract description 41
- 238000006243 chemical reaction Methods 0.000 claims abstract description 31
- 239000012024 dehydrating agents Substances 0.000 claims abstract description 31
- 239000007787 solid Substances 0.000 claims abstract description 31
- 239000005416 organic matter Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002893 slag Substances 0.000 claims abstract description 14
- 238000004064 recycling Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 17
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 12
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 12
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 7
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- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 238000013019 agitation Methods 0.000 claims description 5
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- 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims description 4
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- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 4
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- 230000008569 process Effects 0.000 abstract description 6
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L5/00—Solid fuels
- C10L5/40—Solid fuels essentially based on materials of non-mineral origin
- C10L5/48—Solid fuels essentially based on materials of non-mineral origin on industrial residues and waste materials
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- Environmental & Geological Engineering (AREA)
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- Treatment Of Sludge (AREA)
Abstract
The invention provides a kind of method of antibiotic fermentation bacteria residue solidification dehydration, methods described is：Antibiotic fermentation bacteria residue is mixed with solidification dehydrating agent, curing reaction, the moisture in removing antibiotic fermentation bacteria residue is carried out；Wherein, the solidification dehydrating agent is：Any number of in hydrate, absorbable moisture or the inorganic matter that can be reacted with water and/or organic matter or at least two combination can be formed.The bacteria residue solid mixt that the curing reaction is produced recycling or can carry out burning disposal directly or after being dehydrated.Methods described can be by fast dewatering temperature and complete dehydration temperaturre the reduction 10-90% of the bacteria residue that ferments；Solve the problems, such as that transport difficult, easy secondary fermentation are stored under antibiotic fermentation wet bacteria slag normal temperature produces the treatment process cost such as pollution, dehydration high, be that antibiotic fermentation wet bacteria slag low cost recycling and harmless treatment provide a kind of new method.
Description
Technical field
Technical field is utilized the invention belongs to the treatment of antibiotic fermentation bacteria residue and changing waste into resources, is related to a kind of anti-
The method of raw element fermentation bacteria residue solidification dehydration, more particularly to one kind is right to process with antibiotic fermentation wet bacteria slag
As realizing the side of the dehydration of antibiotic fermentation bacteria residue low-cost solidification and its recycling and harmless treatment
Method.
Background technology
China is antibiotics production state maximum in the world, and the 90% of global antibiotic bulk drug carries by China
For.The production process of antibiotic bulk drug includes the unit process such as fermentation, extraction, refined.In fermentation process
Middle to produce substantial amounts of antibiotic fermentation bacteria residue, China there are about 2,000,000 tons of antibiotic fermentation bacteria residues and urgently locates every year
Reason.Antibiotic fermentation bacteria residue is main by fermentation mycelium, residual antibiotic, remaining culture medium and other generations
Thank to product.Antibiotic bacterium dregs are mishandling, and residual antibiotic therein may induce generation drug-fast bacteria and super
Bacterium, China is listed within 2008《National Hazard waste register》, antibiotic bacterium dregs are by dangerous solid
Discarded object is strictly supervised.
The antibiotic fermentation wet bacteria slag content of organic matter is enriched, and has the value of recycling；But wet bacteria slag is normal
Warm easily secondary fermentation, self-dissolving is thinning, distributes stench, pollutes environment.Wet bacteria slag moisture content is generally
70-90%, and moisture combined with bacteria residue in colloidal state, in the absence of free water, the mechanical means such as centrifugation is difficult to
Dehydration.At present, burn and specification landfill is only antibiotic bacterium dregs processing method for meeting regulation, but
There is a problem of high cost and easily cause secondary pollution.
In the research of antibiotic fermentation bacteria residue processing method, Zhang Guangyi et al. have studied hydro-thermal process antibiotic
Bacteria residue dehydration prepares solid bio-fuel, and the hydrothermal condition of optimization is 180-200 DEG C for the treatment of 30-60min, institute
The solid bio-fuel moisture content of preparation is in 45%-48%.Hydrothermal reaction condition harshness is, it is necessary to high temperature and height
Pressure carries out dehydration, and high energy consumption, processing cost is high.
CN 104212840A disclose a kind of processing method of antibiotic fermentation bacteria residue, including can by hydrochloric acid woods
The fermentation bacteria residue of mycin and gentamicin is well mixed with water, is configured to suspension；Then suspension is carried out
Anaerobic fermentation treatment.Methods described is a kind of efficient hair of the bacteria residue that fermented to Lincomycin Hydrochloride and gentamicin
Ferment handling process.But, methods described cannot in time process a large amount of antibiotic bacterium dregs and its secondary fermentation, and
And it is relatively costly.CN 102728142A disclose a kind of processing method of antibiotic bacterium dregs high-efficiency dehydration, institute
Processing method is stated to comprise the following steps：A bacteria residue by test, is obtained the isoelectric point value of bacteria residue by ()；(b)
Bacteria residue is added into acid solution or alkali lye, isoelectric point value of its pH value obtained by step (a) is adjusted to；C () will
In step (b) products therefrom, flocculant solution, stirring, precipitation, filtering are added, you can.But, institute
State the method high cost of antibiotic bacterium dregs dehydration, complex operation.
The content of the invention
For antibiotic fermentation bacteria residue yield at this stage is big, the treatment process cost such as easy secondary fermentation and dehydration
Situation high, it is described it is an object of the invention to provide a kind of method of antibiotic fermentation bacteria residue solidification dehydration
Method can at normal temperatures realize the solidification dehydration of wet bacteria slag, solve and be difficult under antibiotic fermentation bacteria residue normal temperature
Storage, the problem of transport, are that antibiotic fermentation wet bacteria slag low cost recycling and harmless treatment are provided
A kind of new method.
It is that, up to this purpose, the present invention uses following technical scheme：
The invention provides a kind of method of antibiotic fermentation bacteria residue solidification dehydration, methods described is：By antibiosis
Element fermentation bacteria residue mixes with solidification dehydrating agent, carries out curing reaction, the water in removing antibiotic fermentation bacteria residue
Point；Wherein, the solidification dehydrating agent is：Hydrate, absorbable moisture or the nothing that can be reacted with water can be formed
Any number of in machine thing and/or organic matter or at least two combination.
It is described solidification dehydrating agent can be：Organic matter that hydrate can be formed, the inorganic matter that hydrate can be formed,
The organic matter of absorbable moisture, the inorganic matter of absorbable moisture, the inorganic matter that can be reacted with water or can be anti-with water
In the organic matter answered any one or at least two combination.Typical but non-limiting solidification dehydrating agent group
It is combined into：The inorganic matter and the inorganic matter that can be reacted with water of hydrate can be formed, the organic matter of hydrate can be formed
With the inorganic matter of absorbable moisture, the organic matter that can be reacted with water, the organic matter of absorbable moisture and can be formed
The organic matter of hydrate, can be formed hydrate organic matter, can with water react inorganic matter, hydration can be formed
The inorganic matter of thing and the organic matter etc. that can be reacted with water.
The solidification dehydrating agent is alternatively and contains the nothing that can form hydrate, absorbable moisture or can be reacted with water
Any number of in machine thing and/or organic matter or the mixture of at least two combination.
Those skilled in the art can solidify each component in dehydrating agent according to actual antibiotic bacterium dregs regulation,
So as to reach more preferable dehydrating effect.
The antibiotic fermentation bacteria residue with solidification dehydrating agent reaction mechanism be：By solidifying dehydrating agent and bacteria residue
Mixing, destroy the colloform texture of bacteria residue, the transformation of moisture existence form in bacteria residue is realized, so as to reduce
Dehydration temperaturre, reduces dehydration cost.
The present invention is using the dehydrating agent that solidifies as described above by the moisture removal in antibiotic fermentation bacteria residue.Solidification is anti-
The bacteria residue solid mixt biochemical property stabilization that should be produced, will not further secondary fermentation.Solve antibiotic
Be difficult to the problem that stores, transport under fermentation bacteria residue normal temperature, and antibiotic bacterium dregs secondary fermentation problem, be
Antibiotic fermentation wet bacteria slag low cost recycling and harmless treatment provide a kind of new method.
The antibiotic fermentation bacteria residue derives from beta-lactam antibiotic (such as penicillin), macrolide
Class antibiotic (such as erythromycin), aminoglycoside antibiotics (such as streptomysin), Tetracyclines antibiosis
Plain (such as terramycin), amphenicols antibiotic (such as chloramphenicol), polypeptide antibiotics are (as through the ages
Mycin etc.), act on antibiotic (such as lincomycin, lindamycin, mould through the ages of gram-positive bacteria
Element, bacitracin etc.), act on gram- bacteria antibiotic (such as polymyxins, phosphonomycin, ciramycin,
Seromycin, rifampin etc.), antimycotic antibiotic (such as griseofulvin), antineoplastic antibiotic (such as
Mitomycin, actinomycin D, bleomycin or adriamycin etc.) or antibiotic with immunosuppressive action
In (such as cyclosporin) any one or at least two combination.Typical but non-limiting combination
For：Beta-lactam antibiotic and macrolide antibiotics, aminoglycoside antibiotics, Tetracyclines resist
Raw element and amphenicols antibiotic, polypeptide antibiotics and the antibiotic for acting on gram-positive bacteria, effect
Antibiotic, antimycotic antibiotic, antineoplastic antibiotic in gram- bacteria with there is immunosuppressive action
Antibiotic, beta-lactam antibiotic, macrolide antibiotics, aminoglycoside antibiotics and Fourth Ring
Plain class antibiotic.
The inorganic matter and/or organic matter for forming hydrate is that can form the inorganic salts of hydrate and/or have
Machine salt.
Preferably, the inorganic salts for forming hydrate be sulfate, carbonate, ammonium salt, hydrochloride or
In sulphite any one or at least two combination.It is typical but non-limiting to be combined as：Sulfate
With sulfate, sulfate and carbonate, carbonate and carbonate, carbonate and ammonium salt, hydrochloride, sulfurous
Hydrochlorate and sulfate, carbonate, ammonium salt, hydrochloride and sulphite.
Preferably, the inorganic salts for forming hydrate be sodium carbonate, magnesium chloride, ammonium chloride, calcium chloride,
In aluminum sulfate, magnesium sulfate, copper sulphate, sodium sulphate or sodium acetate any one or at least two combination.
It is typical but non-limiting to be combined as：Sodium carbonate and magnesium chloride, ammonium chloride, calcium chloride and aluminum sulfate, sulfuric acid
Magnesium, copper sulphate, sodium sulphate and sodium acetate, sodium carbonate, magnesium chloride, ammonium chloride and calcium chloride etc..
Preferably, the inorganic matter of the absorbable moisture is anhydrous silica gel.
Preferably, the inorganic matter that can be reacted with water is calcium oxide.
The antibiotic fermentation bacteria residue is 1 with the mass ratio of the solidification dehydrating agent:0.2-1:3, such as 1:0.5、
1:0.8、1:1.0、1:1.2、1:1.5、1:1.8、1:2.0、1:2.3、1:2.5 or 1:2.8 etc., consider solid
Change the factors, preferably 1 such as dehydrating agent cost, bacteria residue treatment effeciency and treatment effect:1-1:2, both can be with
Ensure the effect of bacteria residue solidification dehydration, bacteria residue treatment effeciency and relatively low solidification dehydration higher can be ensured again
Cost.
The temperature of the curing reaction be 0-100 DEG C, such as 5 DEG C, 10 DEG C, 15 DEG C, 20 DEG C, 30 DEG C,
40 DEG C, 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C, 90 DEG C or 95 DEG C etc., preferably 15-50 DEG C.
The time of the curing reaction because choose solidification dehydrating agent and bacteria residue treating capacity it is different and different,
Curing reaction terminal is to obtain what dry and comfortable solid mixt determined.
During the antibiotic fermentation bacteria residue is mechanical agitation, stirs or extrude with the mode that mix of solidification dehydrating agent
Any one or at least two combination.It is typical but non-limiting to be combined as：Mechanical agitation with stir,
Mechanical agitation and extruding, mechanical agitation, stir and extruding.The purpose of the mixing be will solidification dehydrating agent with
Antibiotic fermentation bacteria residue is well mixed, so that the uniform curing dehydration of antibiotic fermentation bacteria residue.
Used as preferred technical scheme, methods described also includes：The bacteria residue solid-state that curing reaction is produced mixes
Thing carries out dewater treatment, the mode of the dewater treatment be in heating, air-dry or evaporating any one or extremely
Lack two kinds of combination, the mode of dewater treatment is as described：Heating is combined with air-dried, heats and evaporation is tied
Close, heating, the air-dried mode combined with evaporation are dehydrated.The bacteria residue that the curing reaction is produced is powder
Shape or other shapes.The shape of the bacteria residue solid mixt is different according to the degree of its solidification dehydration.
Preferably, the temperature of the dewater treatment be 15-160 DEG C, such as 20 DEG C, 25 DEG C, 30 DEG C, 40 DEG C,
50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C, 100 DEG C, 110 DEG C, 120 DEG C, 130 DEG C or 150 DEG C etc., preferably
40-80℃。
Bacteria residue solid mixt recycling after the bacteria residue solid mixt of curing reaction generation and/or dehydration
Or carry out burning disposal.Bacteria residue solid-state mixing after the bacteria residue solid mixt of curing reaction generation and/or dehydration
Thing can be used as solid fuel.
Used as preferred technical scheme, methods described is：It is under the conditions of 0-100 DEG C, antibiotic fermentation is wet
Bacteria residue is 1 according to mass ratio with solidification dehydrating agent:0.2-1:3 mixing, form bacteria residue solid mixt；By bacteria residue
Solid mixt directly or after dehydration recycling or carries out burning disposal, wherein, the temperature of the dehydration
It is 15-160 DEG C.
Compared with prior art, beneficial effects of the present invention are：
(1) method of the antibiotic fermentation bacteria residue solidification dehydration that the present invention is provided, can be by the fast of bacteria residue of fermenting
Fast dehydration temperaturre and complete dehydration temperaturre reduction 10-90%.By taking penicillin mushroom dregs as an example, process blue or green through the method
After mycin fermentation bacteria residue, it is possible to achieve dehydration peak temperature is reduced to 71.9 DEG C, is dehydrated temperature completely by 97.4 DEG C
Degree is reduced to 98.5 DEG C by 162.7 DEG C, and fermentation bacteria residue fast dewatering temperature peak reduction by 27% is dehydrated temperature completely
Degree reduces by 37%, realizes inexpensive dehydration.
(2) method of the antibiotic fermentation bacteria residue solidification dehydration that the present invention is provided so that antibiotic fermentation bacteria residue
Physical behavior there is huge change, dry and comfortable solid-state is changed into by original colloidal state, solve antibiotic hair
The problems such as storage transport, easy secondary fermentation pollution environment are difficult under ferment wet bacteria slag normal temperature, is that recycling is carried
New basis is supplied, tool is of great significance.
Brief description of the drawings
Fig. 1 is the shape appearance figure before and after the antibiotic fermentation bacteria residue solidification dehydration that embodiment 1 is provided, wherein (a)
It is the shape appearance figure before solidification dehydration, (b) is the shape appearance figure after solidification dehydration.
Fig. 2 is the shape appearance figure before and after the antibiotic fermentation bacteria residue solidification dehydration that embodiment 2 is provided, wherein (a)
It is the shape appearance figure before solidification dehydration, (b) is the shape appearance figure after solidification dehydration.
Fig. 3 is the shape appearance figure before and after the antibiotic fermentation bacteria residue solidification dehydration that embodiment 3 is provided, wherein (a)
It is the shape appearance figure before solidification dehydration, (b) is the shape appearance figure after solidification dehydration.
Fig. 4 is the shape appearance figure before and after the antibiotic fermentation bacteria residue solidification dehydration that embodiment 4 is provided, wherein (a)
It is the shape appearance figure before solidification dehydration, (b) is the shape appearance figure after solidification dehydration.
Specific embodiment
Technical scheme, but institute are further illustrated below in conjunction with the accompanying drawings and by specific embodiment
There is embodiment not constitute any limitation to the present invention.
Embodiment 1
By abomacetin fermentation bacteria residue and No. 1 solidification dehydrating agent (main component is sodium carbonate) according to mass ratio 1:0.2
Mixing, carries out curing reaction under 0 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Shape appearance figure before and after the solidification dehydration of abomacetin fermentation bacteria residue is as shown in figure 1, as can be seen from the figure bacteria residue
By after curing reaction, physical pattern is changed into dry and comfortable solid state powder (b) from colloidal state (a).
Embodiment 2
By penicillin fermentation bacteria residue and No. 2 solidifications dehydrating agent (main component is magnesium sulfate) according to mass ratio 1:3 mix
Close, curing reaction is carried out under 100 DEG C, stirring condition, obtain dry and comfortable bacteria residue solid mixt.
Shape appearance figure before and after the solidification dehydration of penicillin fermentation bacteria residue is as shown in Fig. 2 as can be seen from the figure bacteria residue
By after curing reaction, physical pattern is changed into dry and comfortable solid state powder (b) from colloidal state (a).
Embodiment 3
By griseofulvin fermentation bacteria residue and No. 3 solidifications dehydrating agent (main component is copper sulphate) according to mass ratio 1:1
Mixing, carries out curing reaction under 15 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Shape appearance figure before and after griseofulvin fermentation bacteria residue solidification dehydration is as shown in figure 3, as can be seen from the figure bacterium
Slag is by after curing reaction, physical pattern is changed into dry and comfortable solid state powder (b) from colloidal state (a).
Embodiment 4
By lincomycin fermentation bacteria residue and No. 4 solidifications dehydrating agent (main component is sodium sulphate) according to mass ratio 1:2
Mixing, carries out curing reaction under 50 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Shape appearance figure before and after the solidification dehydration of lincomycin fermentation bacteria residue is as shown in figure 4, as can be seen from the figure bacterium
Slag is by after curing reaction, physical pattern is changed into dry and comfortable solid state powder (b) from colloidal state (a).
Embodiment 5
By terramycin fermentation bacteria residue and No. 5 solidifications dehydrating agent (main component is zinc sulfate) according to mass ratio 1:0.8
Mixing, carries out curing reaction under 25 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Embodiment 6
By big mycin fermentation bacteria residue and No. 6 solidifications dehydrating agent (main component is ammonium chloride) according to mass ratio 1:3 mix
Close, curing reaction is carried out under 25 DEG C, stirring condition, obtain dry and comfortable bacteria residue solid mixt.
Embodiment 7
By Ferment of DM bacteria residue and No. 7 solidifications dehydrating agent (main component is magnesium chloride) according to mass ratio 1:1.7
Mixing, carries out curing reaction under 45 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Embodiment 8
By streptomycin fermentation bacteria residue and No. 8 solidifications dehydrating agent (main component is calcium chloride) according to mass ratio 1:2.5
Mixing, carries out curing reaction under 50 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid mixt.
Embodiment 9
By cynnematin fermentation bacteria residue and No. 9 solidification dehydrating agents (main component is magnesium chloride, magnesium sulfate) according to matter
Amount compares 1:1.5 mixing, carry out curing reaction under 50 DEG C, stirring condition, obtain dry and comfortable bacteria residue solid-state mixing
Thing.
Embodiment 10
By vancomycin fermentation bacteria residue with No. 10 solidify dehydrating agent (main component is aluminum sulfate) mixtures according to
Mass ratio 1:0.6 mixing, carries out curing reaction under 30 DEG C, stirring condition, obtains dry and comfortable bacteria residue solid-state and mixes
Compound.
Embodiment 11
By ciramycin fermentation bacteria residue and No. 11 solidification dehydrating agents (main component is ammonium chloride, sodium sulphate) according to matter
Amount compares 1:2.2 mixing, carry out curing reaction under 40 DEG C, stirring condition, obtain dry and comfortable bacteria residue solid-state mixing
Thing.
Embodiment 12
Medecamycin fermentation bacteria residue is pressed with No. 12 solidification dehydrating agents (main component is sodium sulfite, sodium sulphate)
According to mass ratio 1:3 mixing, carry out curing reaction under 15 DEG C, stirring condition, obtain dry and comfortable bacteria residue solid-state
Mixture.
Applicant's statement, the foregoing is only specific embodiment of the invention, but protection scope of the present invention
It is not limited thereto, person of ordinary skill in the field is it will be clearly understood that any skill for belonging to the art
Art personnel the invention discloses technical scope in, the change or replacement that can be readily occurred in all fall within the present invention
Protection domain and it is open within the scope of.
Claims (10)
1. the method for a kind of antibiotic fermentation bacteria residue solidification dehydration, it is characterised in that methods described is：Will
Antibiotic fermentation bacteria residue mixes with solidification dehydrating agent, curing reaction is carried out, in removing antibiotic fermentation bacteria residue
Moisture；Wherein, the solidification dehydrating agent is：Hydrate, absorbable moisture can be formed or can be reacted with water
Any number of in inorganic matter and/or organic matter or at least two combination.
2. method according to claim 1, it is characterised in that the antibiotic fermentation bacteria residue source
In beta-lactam antibiotic, macrolide antibiotics, aminoglycoside antibiotics, Tetracyclines antibiosis
Element, amphenicols antibiotic, polypeptide antibiotics, the antibiotic for acting on gram-positive bacteria, act on
The antibiotic of gram- bacteria, antimycotic antibiotic, antineoplastic antibiotic or with immunosuppressive action
In antibiotic any one or at least two combination.
3. method according to claim 1 and 2, it is characterised in that the nothing for forming hydrate
Machine thing and/or organic matter are the inorganic salts and/or organic salt that can form hydrate；
Preferably, the inorganic salts for forming hydrate be sulfate, carbonate, ammonium salt, hydrochloride or
In sulphite any one or at least two combination；
Preferably, the inorganic salts for forming hydrate be sodium carbonate, magnesium chloride, ammonium chloride, calcium chloride,
In aluminum sulfate, magnesium sulfate, copper sulphate, sodium sulphate or sodium acetate any one or at least two combination；
Preferably, the inorganic matter of the absorbable moisture is anhydrous silica gel；
Preferably, the inorganic matter that can be reacted with water is calcium oxide.
4. according to the method that one of claim 1-3 is described, it is characterised in that the antibiotic fermentation bacteria residue
Mass ratio with the solidification dehydrating agent is 1:0.2-1:3, preferably 1:1-1:2.
5. according to the method that one of claim 1-4 is described, it is characterised in that the temperature of the curing reaction
It is 0-100 DEG C, preferably 15-50 DEG C.
6. method according to claim 1, it is characterised in that the antibiotic fermentation bacteria residue with it is solid
Change dehydrating agent mixing mode for mechanical agitation, stir or extrude in any one or at least two group
Close.
7. according to the method that one of claim 1-6 is described, it is characterised in that methods described also includes：Will
The bacteria residue solid mixt that curing reaction is produced carries out dewater treatment, the mode of the dewater treatment is heating,
Air-dry or evaporation in any one or at least two combination.
8. method according to claim 7, it is characterised in that the temperature of the dewater treatment is
15-160 DEG C, preferably 40-80 DEG C.
9. according to the method that one of claim 1-8 is described, it is characterised in that the bacterium produced to curing reaction
Bacteria residue solid mixt after slag solid mixt and/or dehydration carries out recycling or carries out at burning
Reason.
10. according to the method that one of claim 1-9 is described, it is characterised in that methods described is：
It is 1 according to mass ratio by antibiotic fermentation wet bacteria slag and solidification dehydrating agent under the conditions of 0-100 DEG C:0.2-1:3 mix
Close, form bacteria residue solid mixt；Bacteria residue solid mixt directly or after dehydration recycling or is carried out
Burning disposal, wherein, the temperature of the dehydration is 15-160 DEG C.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109266416A (en) * | 2018-09-12 | 2019-01-25 | 湖南省万木汇生物质燃料有限责任公司 | A kind of compound biomass granular fuel and its preparation method and application |
| CN110342966A (en) * | 2019-07-12 | 2019-10-18 | 沈阳中科微道生物科技有限公司 | A kind of quick, the effective dehydrating method of the useless bacteria residue of vitamin c fermenting |
| CN110813999A (en) * | 2019-11-27 | 2020-02-21 | 湖北共同生物科技有限公司 | Method for curing and dehydrating steroid compound fermentation fungus residues |
| CN112815638A (en) * | 2020-12-31 | 2021-05-18 | 伊犁川宁生物技术股份有限公司 | Method for drying erythromycin thiocyanate fungus residues |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624256A (en) * | 2008-07-09 | 2010-01-13 | 密西西比国际水务有限公司 | Method and device for processing sludge and/or waste residues |
| CN103664126A (en) * | 2012-09-20 | 2014-03-26 | 深圳市海川实业股份有限公司 | Sludge curing treatment agent and method for treating sludge by use of curing treatment agent |
-
2015
- 2015-12-29 CN CN201511006120.3A patent/CN106925593A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624256A (en) * | 2008-07-09 | 2010-01-13 | 密西西比国际水务有限公司 | Method and device for processing sludge and/or waste residues |
| CN103664126A (en) * | 2012-09-20 | 2014-03-26 | 深圳市海川实业股份有限公司 | Sludge curing treatment agent and method for treating sludge by use of curing treatment agent |
Non-Patent Citations (1)
| Title |
|---|
| 张利民，李如章: "GB一青霉素菌渣的脱水处理和含糖量的测定", 《张 家 口 医 学 院 学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109266416A (en) * | 2018-09-12 | 2019-01-25 | 湖南省万木汇生物质燃料有限责任公司 | A kind of compound biomass granular fuel and its preparation method and application |
| CN110342966A (en) * | 2019-07-12 | 2019-10-18 | 沈阳中科微道生物科技有限公司 | A kind of quick, the effective dehydrating method of the useless bacteria residue of vitamin c fermenting |
| CN110813999A (en) * | 2019-11-27 | 2020-02-21 | 湖北共同生物科技有限公司 | Method for curing and dehydrating steroid compound fermentation fungus residues |
| CN112815638A (en) * | 2020-12-31 | 2021-05-18 | 伊犁川宁生物技术股份有限公司 | Method for drying erythromycin thiocyanate fungus residues |
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