CN106924173B - 一种药物负载介孔材料及其制备方法 - Google Patents
一种药物负载介孔材料及其制备方法 Download PDFInfo
- Publication number
- CN106924173B CN106924173B CN201710215848.XA CN201710215848A CN106924173B CN 106924173 B CN106924173 B CN 106924173B CN 201710215848 A CN201710215848 A CN 201710215848A CN 106924173 B CN106924173 B CN 106924173B
- Authority
- CN
- China
- Prior art keywords
- mesoporous material
- polylactic acid
- drug
- chitosan
- crude product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000013335 mesoporous material Substances 0.000 title claims abstract description 67
- 239000003814 drug Substances 0.000 title claims abstract description 48
- 229940079593 drug Drugs 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 72
- 239000004626 polylactic acid Substances 0.000 claims abstract description 72
- 229920001661 Chitosan Polymers 0.000 claims abstract description 69
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 66
- 239000002608 ionic liquid Substances 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000012043 crude product Substances 0.000 claims description 52
- 239000000243 solution Substances 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- 239000000017 hydrogel Substances 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 14
- 238000002791 soaking Methods 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 14
- -1 1-allyl-3-methyl-imidazole chloride salt Chemical class 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000007710 freezing Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 230000008014 freezing Effects 0.000 claims description 10
- 238000004108 freeze drying Methods 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000009833 condensation Methods 0.000 claims description 7
- 230000005494 condensation Effects 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 239000011261 inert gas Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims 2
- 101710134784 Agnoprotein Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 238000011068 loading method Methods 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 16
- 239000002244 precipitate Substances 0.000 description 12
- 239000011148 porous material Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000013267 controlled drug release Methods 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000003509 long acting drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000002336 sorption--desorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000009920 food preservation Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710215848.XA CN106924173B (zh) | 2017-03-29 | 2017-03-29 | 一种药物负载介孔材料及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710215848.XA CN106924173B (zh) | 2017-03-29 | 2017-03-29 | 一种药物负载介孔材料及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN106924173A CN106924173A (zh) | 2017-07-07 |
CN106924173B true CN106924173B (zh) | 2020-11-06 |
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CN201710215848.XA Expired - Fee Related CN106924173B (zh) | 2017-03-29 | 2017-03-29 | 一种药物负载介孔材料及其制备方法 |
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CN (1) | CN106924173B (zh) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1476907A (zh) * | 2003-06-30 | 2004-02-25 | 暨南大学 | 生物活性三维多孔组织工程支架材料及其制备方法 |
CN100431623C (zh) * | 2006-10-23 | 2008-11-12 | 天津大学 | 壳聚糖-聚乳酸共聚物三维多孔支架制备方法 |
CN102321271B (zh) * | 2011-09-15 | 2012-09-05 | 西安交通大学 | 一种生物活性壳聚糖基多孔支架的制备方法 |
CN105017541B (zh) * | 2015-07-09 | 2018-03-16 | 广西师范学院 | 香蕉纤维素微晶/聚乳酸气凝胶及其制备方法和用途 |
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- 2017-03-29 CN CN201710215848.XA patent/CN106924173B/zh not_active Expired - Fee Related
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CN106924173A (zh) | 2017-07-07 |
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Effective date of registration: 20230208 Address after: 073000 West 200m northbound at the intersection of Dingzhou commercial street and Xingding Road, Baoding City, Hebei Province (No. 1910, 19th floor, building 3, jueshishan community) Patentee after: Hebei Kaitong Information Technology Service Co.,Ltd. Address before: 530200 No.8, Longting Road, Yongning District, Nanning City, Guangxi Zhuang Autonomous Region Patentee before: NANNING University Effective date of registration: 20230208 Address after: 261300 No. 46, Dawang Village, Puzhuang Town, Changyi City, Weifang City, Shandong Province Patentee after: Wang Xiwei Address before: 073000 West 200m northbound at the intersection of Dingzhou commercial street and Xingding Road, Baoding City, Hebei Province (No. 1910, 19th floor, building 3, jueshishan community) Patentee before: Hebei Kaitong Information Technology Service Co.,Ltd. |
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Effective date of registration: 20230606 Address after: 323-2, Building 1, North of East Guihua Road, Gaoxin Second Road, Weifang Comprehensive Free Trade Zone, Shandong 261000 Patentee after: Weifang Tuoyun Biotechnology Co.,Ltd. Address before: 261300 No. 46, Dawang Village, Puzhuang Town, Changyi City, Weifang City, Shandong Province Patentee before: Wang Xiwei |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201106 |
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CF01 | Termination of patent right due to non-payment of annual fee |