CN106923842A - A kind of blood glucose monitoring system - Google Patents

A kind of blood glucose monitoring system Download PDF

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Publication number
CN106923842A
CN106923842A CN201710176230.7A CN201710176230A CN106923842A CN 106923842 A CN106923842 A CN 106923842A CN 201710176230 A CN201710176230 A CN 201710176230A CN 106923842 A CN106923842 A CN 106923842A
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value
monitoring
glucose
blood glucose
body temperature
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CN106923842B (en
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刘慧�
刘厚为
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Dongguan Zhongshengda Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/14517Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6832Means for maintaining contact with the body using adhesives
    • A61B5/6833Adhesive patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
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  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The present invention gives a kind of blood glucose monitoring system, it includes mobile terminal, its measured value for passing through the glucose in the glucose sensor monitoring human sweat carried on wearable device is simultaneously sent to mobile terminal, mobile terminal is calculated and is predicted the blood glucose value obtained in certain period of time in future according to the glucose measurements, and the invention effectively can carry out real-time monitoring and prediction to blood sugar for human body.

Description

A kind of blood glucose monitoring system
Technical field
The invention belongs to blood sugar for human body monitoring or detection field, itself more particularly to a kind of blood glucose monitoring system.
Background technology
With industrialized quick process, food composition there occurs that the ratio of great variety, diabetes etc. " rich man's disease " is got over Come bigger, or even it have also appeared the trend of rejuvenation, inventor even has found the situation for having high school student that diabetes occur, and right In diabetes patient, its monitoring is particularly important.
In currently available technology, to its monitoring often through the glucose level in measurement blood, have to tackle The fluctuation of the blood sugar of patient so as to place because of the complication of kidney, nervous system, the blood vessel etc. that elevated blood glucose levels trigger, and then It is guarded and is treated.These technologies can be to carry out effective monitoring to blood sugar and provide many reference frames, such as Chinese patent CN205234512 provides for a kind of wearable high-precision blood sugar detection equipment.The technology for but using at present It is all based on the monitoring of blood sugar, that is to say, that need wound and blood sampling, this prior art is not suitable for the day of non-professional patient Often use, and need wound on the one hand to have pain and use feeling is not good, and have the possibility for causing infection.Meanwhile, blood sugar Monitoring need manually operated, that is to say, that if user it is busier or forget operate and cause monitor something lost Leakage, even if or even using other alerting patterns, but also have ignored risk.So as to it reliably can not do to user To effective daily monitoring, so as to lose the use advantage of Wearable device.
Based on this, inventors herein propose and a kind of be particularly well-suited to the wearable blood glucose system that daily monitoring is used.
The content of the invention
The present invention gives a kind of blood glucose monitoring system, it includes mobile terminal, and including wearable body and can Paste section on wearing body, the wearable body includes wearable part, flexible display screen, control unit, body temperature trans And communication section, the paste section include glucose sensor, communicator and controller, it is characterised in that the paste section can glue Human body skin is affixed on, and the wearable body is worn on the human body skin correspondence stickup by the wearable part Monitor value is simultaneously sent to the control unit, the grape by the position that portion pastes, the body temperature of the body temperature trans monitoring human body The measured value of the glucose in sugared Sensor monitoring human sweat is simultaneously sent to the controller, and the controller is by described logical The measured value is sent to the communication section by news device, and the measured value is sent to the control unit by the communication section, described Control unit also controls the flexible display screen to show the monitor value of the body temperature and the measured value of the glucose, and by institute State communication section and the measured value is sent to the mobile terminal.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enables the glucose and passes after the request signal is received by communicator by some cycles Sensor obtains the measured value of the glucose.
Preferably, the mobile terminal possesses communication device, display part and central processing unit, the central processing unit difference Connect the communication device and display part, and its pass through the communication device obtain the measured value and after being pre-processed with One threshold value of warning for prestoring is compared, when the pretreated measured value is more than the threshold value of warning by the display Portion's display alarm.
Preferably, it is described obtain the measured value and carry out blood glucose value that pretreatment is made up of Monitoring Data calculating with The predictive coefficient of time changing curve is obtained, and computing formula is:
Wherein, n be test number of times and it is not less than 50, YiIt is the blood glucose value that i & lt is obtained, tiIt is i & lt monitoring Time;
And described calculating is terminated the computing formula of predicted value of blood sugar after monitoring t hours and is:
Yt=K (t-tn)+Yn
Wherein, YtTo terminate the blood glucose prediction value after monitoring t hours, K is the Kelvin predictive coefficient being calculated, tnIt is use The time of blood glucose monitoring device last time monitoring, YnIt is the blood glucose value with blood glucose monitoring device last time monitoring, wherein t is not More than 24.
Specific embodiment
This explanation is described further below, it should be appreciated that below not as limitation of the present invention, i.e., originally Deformation of the invention under its core concept is still within protection domain.
Embodiment one.
The present embodiment is related to a kind of wearable blood glucose monitoring device, including wearable body and on wearable body Paste section, the wearable body include wearable part, flexible display screen, control unit, body temperature trans and communication section, institute Stating paste section includes glucose sensor, communicator and controller, it is characterised in that the paste section Pasting is in human body skin Skin, and the wearable body is worn on the position that the human body skin correspondence paste section is pasted by the wearable part Put, monitor value is simultaneously sent to the control unit, the glucose sensor prison by the body temperature of the body temperature trans monitoring human body The measured value of the glucose surveyed in human sweat is simultaneously sent to the controller, and the controller will be described by the communicator Measured value is sent to the communication section, and the measured value is sent to the control unit by the communication section, and the control unit is also controlled Make the flexible display screen and show the monitor value of the body temperature and the measured value of the glucose, and will by the communication section The measured value is sent to mobile terminal.
Here wearable body can select the configuration of the common various wearable devices of in the market, such as bracelet, armlet Deng, preferred wrist-watch in this implementation, and wrist strap by wrist-watch further constrains the paste section so that paste section one side energy Enough it is close to skin, paste section is touched when on the other hand preventing from using causes coming off for paste section.On the other hand, paste section is selected It is the splendid product of permeability, user will not produce sense of discomfort because of stickup.
Preferably, the glucose sensor is Graphene flexible patch sensor.That the sensor is selected is Jin great Jiong A novel sensor that team's research and development are promoted, it uses the patch-type of the gold net processing for adding gold grain formation in Graphene to pass Sensor, its size can accomplish also smaller than identity card, and it can detect G/W therein by the sweat of body surface It is flat, and then obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enables the glucose and passes after the request signal is received by communicator by some cycles Sensor obtains the measured value of the glucose.After such setting is carried out, this product can be opened all at any time Sensor is opened, and is inferred human body whether to have the possibility of perspiration by the monitor value of body temperature and is carried out the monitoring of blood sugar.And its This equipment is in holding state and reduces consumption in the case of him.
Embodiment two.
The present invention gives a kind of blood glucose monitoring system, it includes mobile terminal, and including wearable body and can Paste section on wearing body, the wearable body includes wearable part, flexible display screen, control unit, body temperature trans And communication section, the paste section include glucose sensor, communicator and controller, it is characterised in that the paste section can glue Human body skin is affixed on, and the wearable body is worn on the human body skin correspondence stickup by the wearable part Monitor value is simultaneously sent to the control unit, the grape by the position that portion pastes, the body temperature of the body temperature trans monitoring human body The measured value of the glucose in sugared Sensor monitoring human sweat is simultaneously sent to the controller, and the controller is by described logical The measured value is sent to the communication section by news device, and the measured value is sent to the control unit by the communication section, described Control unit also controls the flexible display screen to show the monitor value of the body temperature and the measured value of the glucose, and by institute State communication section and the measured value is sent to the mobile terminal.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enables the glucose and passes after the request signal is received by communicator by some cycles Sensor obtains the measured value of the glucose.
Preferably, the mobile terminal possesses communication device, display part and central processing unit, the central processing unit difference Connect the communication device and display part, and its pass through the communication device obtain the measured value and after being pre-processed with One threshold value of warning for prestoring is compared, when the pretreated measured value is more than the threshold value of warning by the display Portion's display alarm.
Embodiment three.
The present embodiment gives a kind of blood glucose monitoring system, and it includes mobile terminal, and including wearable body and Paste section on wearable body, the wearable body includes that wearable part, flexible display screen, control unit, body temperature are passed Sensor and communication section, the paste section include glucose sensor, communicator and controller, it is characterised in that the paste section Pasting is worn on described in human body skin correspondence in human body skin, and the wearable body by the wearable part Monitor value is simultaneously sent to the control unit by the position that paste section is pasted, the body temperature of the body temperature trans monitoring human body, described The measured value of the glucose in glucose sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through institute State communicator and the measured value be sent to the communication section, the measured value is sent to the control unit by the communication section, The control unit also controls the flexible display screen to show the monitor value of the body temperature and the measured value of the glucose, and leads to Cross the communication section and the measured value is sent to the mobile terminal.The APP that matching is preinstalled with the mobile terminal comes side Just user operates to the system, such as reading histories data, sets type of alarm, sets long-range alternative contact people, is needing Will when carry out automatic actively contact etc..
In addition glucose sensor is Graphene flexible patch sensor.The Shi Jin great Jiong team research and development that the sensor is selected A novel sensor promoted, it adds the golden patch-type sensor for netting processing that gold grain is formed in using Graphene, its Size can accomplish also smaller than identity card, and it can detect glucose level therein by the sweat of body surface, and then Obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enables the glucose and passes after the request signal is received by communicator by some cycles Sensor obtains the measured value of the glucose.
The setting of the body temperature threshold value, the present embodiment has done an improvement, i.e., no longer using the threshold of fixation commonly used in the art The mode of value, when the system is used for the first time, control unit obtains the average body of user by the temperature monitoring of a cycle Temperature, then will increase by 0.5 DEG C as the threshold value again on the basis of the mean body temperature.Such improvement causes that the system is more fitted The actual conditions of human body.
Preferably, the mobile terminal possesses communication device, display part and central processing unit, the central processing unit difference Connect the communication device and display part, and its pass through the communication device obtain the measured value and after being pre-processed with One threshold value of warning for prestoring is compared, when the pretreated measured value is more than the threshold value of warning by the display Portion's display alarm.
And in Practical experiments, inventor also found a problem, the early warning for being exactly blood sugar is to need in advance, on the one hand The monitoring of the glucose of body fluid has been a delayed monitoring, and blood sugar is reacted from the level of the glucose of body fluid one The backwardness of time, and the change of blood sugar is a regular process, i.e., should be according to the Changing Pattern of blood sugar and delayed Time period studies the real change of blood sugar rule of simulation and accomplishes timely early warning.
For this, inventors herein propose one kind and obtain the measured value and carry out pretreatment by calculating by supervising according to described The blood glucose value for surveying data composition changes over time the mode that the predictive coefficient of curve is obtained, and computing formula is:
Wherein, n be test number of times and it is not less than 50, YiIt is the blood glucose value that i & lt is obtained, tiIt is i & lt monitoring Time;
And described calculating is terminated the computing formula of predicted value of blood sugar after monitoring t hours and is:
Yt=K (t-tn)+Yn
Wherein, YtTo terminate the blood glucose prediction value after monitoring t hours, K is the Kelvin predictive coefficient being calculated, tnIt is use The time of blood glucose monitoring device last time monitoring, YnIt is the blood glucose value with blood glucose monitoring device last time monitoring, wherein t is not More than 24.
Example IV.
The present embodiment gives a kind of blood glucose monitoring system, and it includes mobile terminal, and including wearable body and Paste section on wearable body, the wearable body includes that wearable part, flexible display screen, control unit, body temperature are passed Sensor and communication section, the paste section include glucose sensor, communicator and controller, it is characterised in that the paste section Pasting is worn on described in human body skin correspondence in human body skin, and the wearable body by the wearable part Monitor value is simultaneously sent to the control unit by the position that paste section is pasted, the body temperature of the body temperature trans monitoring human body, described The measured value of the glucose in glucose sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through institute State communicator and the measured value be sent to the communication section, the measured value is sent to the control unit by the communication section, The control unit also controls the flexible display screen to show the monitor value of the body temperature and the measured value of the glucose, and leads to Cross the communication section and the measured value is sent to the mobile terminal.The APP that matching is preinstalled with the mobile terminal comes side Just user operates to the system, such as reading histories data, sets type of alarm, sets long-range alternative contact people, is needing Will when carry out automatic actively contact etc..
In addition glucose sensor is Graphene flexible patch sensor.The Shi Jin great Jiong team research and development that the sensor is selected A novel sensor promoted, it adds the golden patch-type sensor for netting processing that gold grain is formed in using Graphene, its Size can accomplish also smaller than identity card, and it can detect glucose level therein by the sweat of body surface, and then Obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enables the glucose and passes after the request signal is received by communicator by some cycles Sensor obtains the measured value of the glucose.
The setting of the body temperature threshold value, the present embodiment has done an improvement, i.e., no longer using the threshold of fixation commonly used in the art The mode of value, when the system is used for the first time, control unit obtains the average body of user by the temperature monitoring of a cycle Temperature, then will increase by 0.5 DEG C as the threshold value again on the basis of the mean body temperature.Such improvement causes that the system is more fitted The actual conditions of human body.
Preferably, the mobile terminal possesses communication device, display part and central processing unit, the central processing unit difference Connect the communication device and display part, and its pass through the communication device obtain the measured value and after being pre-processed with One threshold value of warning for prestoring is compared, for this firstly for sweat dextrose equivalent, it is adopted according to the fixed cycle Sample.
Additionally, inventors herein propose one kind and obtaining the measured value and carrying out pretreatment by calculating by monitoring according to described The blood glucose value of data composition changes over time the mode that the predictive coefficient of curve is obtained, and computing formula is:
Wherein, n be test number of times and it is not less than 50, YiIt is the blood glucose value that i & lt is obtained, tiIt is i & lt monitoring Time;
And described calculating is terminated the computing formula of predicted value of blood sugar after monitoring t hours and is:
Yt=K (t-tn)+Yn
Wherein, YtTo terminate the blood glucose prediction value after monitoring t hours, K is the Kelvin predictive coefficient being calculated, tnIt is use The time of blood glucose monitoring device last time monitoring, YnIt is the blood glucose value with blood glucose monitoring device last time monitoring, wherein t is not More than 24.
Also by the predicted value plus an individual Watch Error value c, the error amount is used to embody sweat Portugal last the present embodiment The error of grape sugar value and blood glucose value, so we are to have obtained a predicted value for revised blood sugar, then in mobile terminal In be provided with blood sugar several threshold values.In the present embodiment, wearable device also sets up a melbine injection release dress Put, it can carry out injection operation with controlled.After the predicted value of blood sugar is triggered to the threshold value of different ranks, mobile terminal Different actions are taken to correspond to, one-level sends vibrations and audible alarm and sends signal and controls the melbine to inject release dress Put and user is injected, and mobile terminal is carried out to hospital and programmed emergency transmission short message automatically after touching secondary alarm Remind.

Claims (5)

1. a kind of blood glucose monitoring system, it includes mobile terminal, and viscous including wearable body and on wearable body Patch portion, the wearable body includes wearable part, flexible display screen, control unit, body temperature trans and communication section, described viscous Patch portion include glucose sensor, communicator and controller, it is characterised in that the paste section Pasting in human body skin, and And the wearable body is worn on the position that the human body skin correspondence paste section is pasted, institute by the wearable part State the body temperature of body temperature trans monitoring human body and monitor value is sent to the control unit, the glucose sensor monitors human body The measured value of the glucose in sweat is simultaneously sent to the controller, and the controller passes through the communicator by the measured value The communication section is sent to, the measured value is sent to the control unit by the communication section, and the control unit also controls described Flexible display screen shows the monitor value of the body temperature and the measured value of the glucose, and by the communication section by the survey Value is sent to the mobile terminal.
2. blood glucose monitoring system as claimed in claim 1, it is characterised in that also prestores body temperature threshold value in the control unit, And the monitor value of its body temperature and the body temperature threshold value, and when the monitor value of the body temperature exceedes the body temperature threshold value Shi Suoshu control units send a request signal by the communication section, and the controller is receiving the request by communicator After signal the measured value that the glucose sensor obtains the glucose is enabled by some cycles.
3. blood glucose monitoring system as claimed in claim 2, it is characterised in that the mobile terminal possesses communication device, display Portion and central processing unit, the central processing unit connect the communication device and display part respectively, and it is by the communication Device obtains the measured value and is compared with the threshold value of warning that prestores after being pre-processed, when the pretreated survey Value be more than the threshold value of warning when by the display part display alarm.
4. blood glucose monitoring system as claimed in claim 3, it is characterised in that the glucose sensor is Graphene flexible paste Piece sensor.
5. blood glucose monitoring system as claimed in claim 3, it is characterised in that the acquisition measured value is simultaneously pre-processed The predictive coefficient that curve is changed over time by calculating the blood glucose value being made up of Monitoring Data is obtained, and computing formula is:
K = Σ i = 1 n Y i t i - 1 n ( Σ i = 1 n Y i Σ i = 1 n t i ) Σ i = 1 n t i 2 - 1 n ( Σ i = 1 n t i ) 2
Wherein, n be test number of times and it is not less than 50, YiIt is the blood glucose value that i & lt is obtained, tiFor i & lt monitoring when Between;
And described calculating is terminated the computing formula of predicted value of blood sugar after monitoring t hours and is:
Yt=K (t-tn)+Yn
Wherein, YtTo terminate the blood glucose prediction value after monitoring t hours, K is the Kelvin predictive coefficient being calculated, tnIt is to use blood sugar The time of monitoring device last time monitoring, YnIt is the blood glucose value with blood glucose monitoring device last time monitoring, wherein t is not more than 24。
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CN106859663A (en) * 2017-03-23 2017-06-20 刘厚为 A kind of wearable blood glucose monitoring device and its system
CN111281360A (en) * 2020-03-06 2020-06-16 中国人民解放军陆军军医大学第一附属医院 Health monitoring system for smart bracelet

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106859663A (en) * 2017-03-23 2017-06-20 刘厚为 A kind of wearable blood glucose monitoring device and its system
CN106859663B (en) * 2017-03-23 2018-03-23 刘厚为 A kind of wearable blood glucose monitoring device and its system
CN108309314A (en) * 2017-03-23 2018-07-24 佛山市洛克威特科技有限公司 A kind of wearable blood glucose monitoring device and its system
CN108309315A (en) * 2017-03-23 2018-07-24 佛山市洛克威特科技有限公司 A kind of wearable blood glucose monitoring device and its system
CN111281360A (en) * 2020-03-06 2020-06-16 中国人民解放军陆军军医大学第一附属医院 Health monitoring system for smart bracelet

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