CN106913952A - A kind of single thread medical multifunctional nasal obstruction and preparation method thereof - Google Patents
A kind of single thread medical multifunctional nasal obstruction and preparation method thereof Download PDFInfo
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- CN106913952A CN106913952A CN201710094370.XA CN201710094370A CN106913952A CN 106913952 A CN106913952 A CN 106913952A CN 201710094370 A CN201710094370 A CN 201710094370A CN 106913952 A CN106913952 A CN 106913952A
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- medical multifunctional
- single thread
- nasal obstruction
- thread medical
- stuffy nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a kind of single thread medical multifunctional nasal obstruction and preparation method thereof.Described single thread medical multifunctional nasal obstruction, it is characterised in that only by an one thread through knitting one-shot forming.Porosity of the present invention is high, and the connectedness in hole reaches 100%, therefore with good gas permeability.Good elasticity can make it be fitted well with human nasal threshold form.Good supportive ensure that it can stably set in nose threshold.Water suction and water retention property are excellent.It is easy to carry medicine and local controllable sustained-release medicine can be realized.It has been provided simultaneously with imbibition, ventilative and administration functions.Structural reduction, moulding process is controllable, easy realization is automated and standardized.Can be by changing thickness of yarn, tension force, the number of turns and pin number, size, aperture and porosity to having a stuffy nose carry out any regulation.Using attractive in appearance, specific aim, practicality and replicability are strong.
Description
Technical field
The present invention relates to a kind of single thread medical multifunctional nasal obstruction and preparation method thereof, belong to medical instruments field.
Background technology
Runny nose that rhinitis, nasosinusitis, flu etc. cause, nasal obstruction, the schneiderian membrane symptom such as swell and ache are very normal in daily life
See, the life that gives people, study and work bring no small puzzlement.At present, for runny nose symptom, clinically also without one kind
Effective method gives and processes.Can only be alleviated by way of oral drug for treating rhinitis, nasosinusitis medicine or cold drug, but the cycle
Long, slowly effect, it is most important that the targeted therapy effect of medicine is poor.Medicine enters after human circulation blood, not only acts on
In nasal cavity inflammation position, can also reach in other normal structure organs, there is side effect hidden danger.Therefore, common patient one side work
Make, while with cotton balls or health spitball plug nostril phenomenon.This not only unsightly, has an effect on breathing, has potential safety hazard, drops
Cotton fiber have risk into respiratory tract.The alleviation swollen and ache to nasal obstruction and schneiderian membrane, can use dropping liquid, spray and use at present
The modes such as ventilating nasal patch are alleviated.However, dropping liquid and the mode of spraying are administered, medicine is easy to run off, the drug action time is short, easily
Repeatedly, inconvenience is operated.Ventilating nasal patch by percutaneous drug delivery, operational efficiency is low, the cycle is long, slowly effect, using unsightly, also limit
Its popularization and application.
Therefore, had a stuffy nose the invention provides a kind of single thread medical multifunctional, be provided simultaneously with imbibition, ventilation and part controllable slow
The function of drug release thing, can disposably solve the problems such as runny nose, nasal obstruction and local administration difficulty.Through retrieval, to the present invention it is similar but
The documents and materials for having essential difference only have 1, a kind of multipurpose nasal plug (application number by nasal-cavity administration：
200510098838.X).The nasal obstruction is made up of hollow ball and spindle clamp, is adopted with latex, silica gel, plastics, metal or other materials
With perfusion, membrane, blow, press, be molded, metal die is suppressed etc., and method prepares nasal obstruction.It is administered by the way that medicine is loaded into hollow ball.It is aobvious
And be clear to, compared to nasal obstruction of the present invention, the nasal obstruction structure and preparation technology complexity, unitary function, using unsightly and
Practicality is not strong.As can be seen here, a kind of single thread medical multifunctional nasal obstruction involved in the present invention, compared with being had a stuffy nose more than, has
Substantial difference, with novelty, creativeness, practicality and irreplaceability.
The content of the invention
It is an object of the invention to provide a kind of single thread medical multifunctional nasal obstruction, to solve existing alleviation runny nose, nasal obstruction and nose
The problem of the medicine equipment missing of mucosal swelling pain symptom.
In order to achieve the above object, had a stuffy nose the invention provides a kind of single thread medical multifunctional, it is characterised in that only by one
One thread is through knitting one-shot forming.
Preferably, described yarn is superabsorbent fiber yarn.
Preferably, described knitting method is hour hand method.
Preferably, size, aperture and the porosity that described medical multifunctional is had a stuffy nose can be by changing thickness of yarn, opening
At least one in power, the number of turns and pin number carries out any regulation.
Preferably, described medical multifunctional nasal obstruction is hollow structure.
Preferably, described medical multifunctional nasal obstruction is ellipsoid.
Preferably, the connectedness in the hole of described medical multifunctional nasal obstruction is 100%.
Preferably, described medical multifunctional nasal obstruction is single layer structure.
Present invention also offers a kind of preparation method of single thread medical multifunctional nasal obstruction, it is characterised in that including following step
Suddenly：
The first step：By an one thread on knitting rod around an initial ring, m pin hour hands are then played on initial ring with crochet hook
First lap is formed, m is the integer more than or equal to 1；
Second step：Enclosed from second, often enclosing hour hand number increases by one, continuously knit n circles, n is the integer more than or equal to 1；
3rd step：Enclosed from (n+1)th, often enclose hour hand number and reduce one, until closing up, prototype is prepared and completed；
4th step：Load medicine is carried out to prototype using infusion process or coating, single thread medical multifunctional nasal obstruction is prepared and completed.
Preferably, described m is 3-9.
Preferably, described n is 2-9.
Preferably, the medicine that described medicine swells and ache for the alleviation nasal obstruction and schneiderian membrane of Clinical practice.
Compared with prior art, the beneficial effects of the invention are as follows：
1st, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, only by an one thread through knitting one-shot forming, knot
Structure is brief, without chopped fiber falling fiber risk.
2nd, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, with good elasticity and support performance, can
It is enough to be fitted well with nose threshold, the stably set in nose threshold is can guarantee that again.
3rd, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, porosity is high and hole connectedness reaches 100%,
Therefore possesses good gas permeability.
4th, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, water suction and water retention property are good, can effectively delay
Solution runny nose symptom.
5th, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, carries prescription just and can realize that the part of medicine is controllable
Sustained release, operational efficiency is high, effect is good, lasting.
6th, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, can by change thickness of yarn, tension force, the number of turns with
And pin number, size, aperture and porosity to having a stuffy nose carry out any regulation.
7th, a kind of single thread medical multifunctional nasal obstruction provided by the present invention, is provided simultaneously with imbibition, ventilation and administration functions, makes
With attractive in appearance, practicality and with strong points.
8th, a kind of preparation method of single thread medical multifunctional nasal obstruction provided by the present invention is hour hand method, and technique is brief, stream
Journey is short, time-consuming few, easily automation and standardization.
9th, a kind of single thread medical multifunctional nasal obstruction provided by the present invention is easy to carry medicine and can realize local controllable sustained-release medicine
Thing.
Brief description of the drawings
Fig. 1 is a kind of single thread medical multifunctional nasal obstruction structural representation.
Fig. 2 is three kinds of single thread medical multifunctional nasal obstruction medicament slow release figures.Wherein, the correspondence of curve 1 embodiment 1, the correspondence of curve 2
Embodiment 2, the correspondence embodiment 3 of curve 3.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.Additionally, after present disclosure has been read, those skilled in the art can make to the present invention
Various changes or modification, these equivalent form of values equally fall within the application appended claims limited range.
Embodiment 1
As shown in figure 1, a kind of single thread medical multifunctional nasal obstruction, only by a superabsorbent fiber yarn (Technical
Absorbents Ltd, No.2085206) through the knitting one-shot forming of hour hand method.Described medical multifunctional nasal obstruction is hollow ellipse
Body.
Described medical multifunctional nasal obstruction porosity is high, and the connectedness in hole reaches 100%, therefore is breathed freely with good
Property.Good elasticity can make it be fitted well with human nasal threshold form.Good supportive ensure that it can be with nose threshold
Stably set.Water suction and water retention property are excellent.It is easy to carry medicine and local controllable sustained-release medicine can be realized.Structural reduction, shaping
Technique is controllable, easy realization is automated and standardized.
Present invention also offers the preparation method that above-mentioned medical multifunctional is had a stuffy nose, concretely comprise the following steps：
The first step：By a superabsorbent fiber yarn on knitting rod around an initial ring, then with crochet hook in initial ring
Go up 3 pin hour hands and form first lap.
Second step：Enclosed from second, often enclosing hour hand number increases by one, continuously knits 3 circles.
3rd step：Enclosed from the 4th, often enclose hour hand number and reduce one, until closing up, prototype is prepared and completed.
4th step：Load medicine is carried out to prototype using infusion process, by the Triamcinolone acetonide solution that prototype immersion concentration is 22 μ g/mL
After middle 10min, taking-up is dried, and Multifunction nose filter is prepared and completed.
The Multifunction nose filter maximum radius for being obtained is 4mm, is highly 6mm.Can be used for the alleviation of cold stuffy nasal obstruction symptom, thoroughly
Gas is good, and imbibition effect is obvious.
Embodiment 2
As shown in figure 1, a kind of single thread medical multifunctional nasal obstruction, only by a superabsorbent fiber yarn (Technical
Absorbents Ltd, No.2085208) through the knitting one-shot forming of hour hand method.Described medical multifunctional nasal obstruction is hollow ellipse
Body.
Described medical multifunctional nasal obstruction porosity is high, and the connectedness in hole reaches 100%, therefore is breathed freely with good
Property.Good elasticity can make it be fitted well with human nasal threshold form.Good supportive ensure that it can be with nose threshold
Stably set.Water suction and water retention property are excellent.It is easy to carry medicine and local controllable sustained-release medicine can be realized.Structural reduction, shaping
Technique is controllable, easy realization is automated and standardized.
Present invention also offers the preparation method that above-mentioned medical multifunctional is had a stuffy nose, concretely comprise the following steps：
The first step：By a superabsorbent fiber yarn on knitting rod around an initial ring, then with crochet hook in initial ring
Go up 6 pin hour hands and form first lap.
Second step：Enclosed from second, often enclosing hour hand number increases by one, continuously knits 4 circles.
3rd step：Enclosed from the 5th, often enclose hour hand number and reduce one, until closing up, prototype is prepared and completed.
4th step：Load medicine is carried out to prototype using infusion process, by the Triamcinolone acetonide solution that prototype immersion concentration is 44 μ g/mL
After middle 10min, taking-up is dried, and Multifunction nose filter is prepared and completed.
The Multifunction nose filter maximum radius for being obtained is 5mm, is highly 7mm.Can be used for the alleviation of cold stuffy nasal obstruction symptom, thoroughly
Gas is good, and imbibition effect is obvious.
Embodiment 3
As shown in figure 1, a kind of single thread medical multifunctional nasal obstruction, only by a superabsorbent fiber yarn (Technical
Absorbents Ltd, No.2085210) through the knitting one-shot forming of hour hand method.Described medical multifunctional nasal obstruction is hollow ellipse
Body.
Described medical multifunctional nasal obstruction porosity is high, and the connectedness in hole reaches 100%, therefore is breathed freely with good
Property.Good elasticity can make it be fitted well with human nasal threshold form.Good supportive ensure that it can be with nose threshold
Stably set.Water suction and water retention property are excellent.It is easy to carry medicine and local controllable sustained-release medicine can be realized.Structural reduction, shaping
Technique is controllable, easy realization is automated and standardized.
Present invention also offers the preparation method that above-mentioned medical multifunctional is had a stuffy nose, concretely comprise the following steps：
The first step：By a superabsorbent fiber yarn on knitting rod around an initial ring, then with crochet hook in initial ring
Go up 9 pin hour hands and form first lap.
Second step：Enclosed from second, often enclosing hour hand number increases by one, continuously knits 8 circles.
3rd step：Enclosed from the 9th, often enclose hour hand number and reduce one, until closing up, prototype is prepared and completed.
4th step：Load medicine is carried out to prototype using coating, the Triamcinolone acetonide solution that concentration is 66 μ g/mL is coated in prototype
On, drying, Multifunction nose filter is prepared and completed.
The Multifunction nose filter maximum radius for being obtained is 6mm, is highly 8mm.Can be used for the alleviation of cold stuffy nasal obstruction symptom, thoroughly
Gas is good, and imbibition effect is obvious.
The single thread medical multifunctional nasal obstruction of embodiment 1-3 is respectively placed in the centrifuge tube for filling 10mL PBS solutions,
Constant temperature oscillation at 37 DEG C；1mL solution is taken out per 5min, measurement of ultraviolet-visible spectrophotometer absorbance is used；Mended toward centrifuge tube
1mLPBS solution is filled, liquid volume constant in centrifuge tube is kept；Triamcinolone acetonide concentration is calculated by Triamcinolone acetonide calibration curve equation
And cumulative release amount and map, as a result as shown in Figure 2.
Claims (10)
1. a kind of single thread medical multifunctional is had a stuffy nose, it is characterised in that only by an one thread through knitting one-shot forming.
2. single thread medical multifunctional as claimed in claim 1 is had a stuffy nose, it is characterised in that described yarn is superabsorbent fiber yarn
Line.
3. single thread medical multifunctional as claimed in claim 1 is had a stuffy nose, it is characterised in that described knitting method is hour hand method.
4. single thread medical multifunctional as claimed in claim 1 is had a stuffy nose, it is characterised in that described single thread medical multifunctional nasal obstruction
Size, aperture and porosity can carry out arbitrarily by changing at least one in thickness of yarn, tension force, the number of turns and pin number
Regulation.
5. single thread medical multifunctional as claimed in claim 1 is had a stuffy nose, it is characterised in that described single thread medical multifunctional nasal obstruction
It is hollow structure.
6. single thread medical multifunctional as claimed in claim 1 is had a stuffy nose, it is characterised in that described single thread medical multifunctional nasal obstruction
It is ellipsoid.
7. any one of claim 1-6 single thread medical multifunctional nasal obstruction preparation method, it is characterised in that including with
Lower step：
The first step：By an one thread on knitting rod around an initial ring, m pin hour hands are then played on initial ring with crochet hook and are formed
First lap, m is the integer more than or equal to 1；
Second step：Enclosed from second, often enclosing hour hand number increases by one, continuously knit n circles, n is the integer more than or equal to 1；
3rd step：Enclosed from (n+1)th, often enclose hour hand number and reduce one, until closing up, prototype is prepared and completed；
4th step：Load medicine is carried out to prototype using infusion process or coating, single thread medical multifunctional nasal obstruction is prepared and completed.
8. the preparation method that single thread medical multifunctional as claimed in claim 7 is had a stuffy nose, it is characterised in that described m is 3-9.
9. the preparation method that single thread medical multifunctional as claimed in claim 7 is had a stuffy nose, it is characterised in that described n is 2-9.
10. the preparation method of single thread medical multifunctional as claimed in claim 7 nasal obstruction, it is characterised in that described medicine is
The medicine that the alleviation nasal obstruction and schneiderian membrane of Clinical practice swell and ache.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710094370.XA CN106913952B (en) | 2017-02-21 | 2017-02-21 | Single-yarn medical multifunctional nasal plug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710094370.XA CN106913952B (en) | 2017-02-21 | 2017-02-21 | Single-yarn medical multifunctional nasal plug and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106913952A true CN106913952A (en) | 2017-07-04 |
| CN106913952B CN106913952B (en) | 2020-08-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710094370.XA Active CN106913952B (en) | 2017-02-21 | 2017-02-21 | Single-yarn medical multifunctional nasal plug and preparation method thereof |
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| Country | Link |
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2093649U (en) * | 1991-04-11 | 1992-01-22 | 晁华 | Miniature medicine-plug for prevention or cure of having cold |
| US6214029B1 (en) * | 2000-04-26 | 2001-04-10 | Microvena Corporation | Septal defect occluder |
| WO2004084872A1 (en) * | 2003-03-26 | 2004-10-07 | Metris Therapeutics Ltd. | Drug delivery device comprising a mesh sleeve |
| WO2005051444A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| EP2266502A1 (en) * | 2000-12-19 | 2010-12-29 | Abbott Laboratories Vascular Enterprises Limited | Apparatus for stenting with enhanced protection against embolism, restenosis and thrombus formation |
| CN202087141U (en) * | 2011-04-29 | 2011-12-28 | 庞伟杰 | Filter net block |
| CN104684512A (en) * | 2012-07-27 | 2015-06-03 | 迅息Pty有限公司 | Improvements relating to nasal dilation devices |
| CN204521069U (en) * | 2014-12-25 | 2015-08-05 | 殷敏 | A kind of sinunasal degradable controlled release drug stent |
| CN204562276U (en) * | 2015-05-09 | 2015-08-19 | 无锡市人民医院 | Nasal packing slow release treatment pump |
| CN104971414A (en) * | 2014-04-01 | 2015-10-14 | 黄震山 | Medicine sustained release device |
| CN106137482A (en) * | 2015-04-27 | 2016-11-23 | 浦易（上海）生物技术有限公司 | A kind of nasal sinuses support and induction system |
| CN106344232A (en) * | 2015-07-14 | 2017-01-25 | 浦易（上海）生物技术有限公司 | Sustained release medicine bracket for nasal cavity, forming method and application thereof |
-
2017
- 2017-02-21 CN CN201710094370.XA patent/CN106913952B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2093649U (en) * | 1991-04-11 | 1992-01-22 | 晁华 | Miniature medicine-plug for prevention or cure of having cold |
| US6214029B1 (en) * | 2000-04-26 | 2001-04-10 | Microvena Corporation | Septal defect occluder |
| EP2266502A1 (en) * | 2000-12-19 | 2010-12-29 | Abbott Laboratories Vascular Enterprises Limited | Apparatus for stenting with enhanced protection against embolism, restenosis and thrombus formation |
| WO2004084872A1 (en) * | 2003-03-26 | 2004-10-07 | Metris Therapeutics Ltd. | Drug delivery device comprising a mesh sleeve |
| WO2005051444A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| CN202087141U (en) * | 2011-04-29 | 2011-12-28 | 庞伟杰 | Filter net block |
| CN104684512A (en) * | 2012-07-27 | 2015-06-03 | 迅息Pty有限公司 | Improvements relating to nasal dilation devices |
| CN104971414A (en) * | 2014-04-01 | 2015-10-14 | 黄震山 | Medicine sustained release device |
| CN204521069U (en) * | 2014-12-25 | 2015-08-05 | 殷敏 | A kind of sinunasal degradable controlled release drug stent |
| CN106137482A (en) * | 2015-04-27 | 2016-11-23 | 浦易（上海）生物技术有限公司 | A kind of nasal sinuses support and induction system |
| CN204562276U (en) * | 2015-05-09 | 2015-08-19 | 无锡市人民医院 | Nasal packing slow release treatment pump |
| CN106344232A (en) * | 2015-07-14 | 2017-01-25 | 浦易（上海）生物技术有限公司 | Sustained release medicine bracket for nasal cavity, forming method and application thereof |
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|---|---|
| CN106913952B (en) | 2020-08-25 |
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