CN106908576A - Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof - Google Patents
Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof Download PDFInfo
- Publication number
- CN106908576A CN106908576A CN201710037151.8A CN201710037151A CN106908576A CN 106908576 A CN106908576 A CN 106908576A CN 201710037151 A CN201710037151 A CN 201710037151A CN 106908576 A CN106908576 A CN 106908576A
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- China
- Prior art keywords
- emulsus
- class
- cadmium
- phases
- heavy metal
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/20—Metals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
Abstract
The present invention relates to emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof, it is included：Emulsus class cosmetic base, and heavy metal cadmium is dispersed in emulsus class cosmetic base, and uniformity and stability reach national grade ii standard material requirement, sample preparation raw material is easy to get, method is simple, reliable and stable, success rate is high, repeatable strong, all significant to improving Cosmetic Manufacture, cosmetics supervision and detection management work standardization etc..
Description
Technical field
The present invention relates to emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof, emulsus class cosmetics
It is one of the most frequently used formulation in daily cosmetics, its standard substance is a kind of measurement criteria, is mainly used in calibration measurement utensil
With the degree of accuracy for evaluating measuring method.
Background technology
Heavy metal analysis in cosmetics are one of important leverage measures of cosmetics safety, and recent year is to making up
The detection of contents of heavy metal elements in product, essentially according to 2007 editions《Cosmetics health specification》Requirement, heavy metal element
Lead, mercury, arsenic content are detected, and heavy metal element cadmium and its compound are put into cosmetics disabling component, but because cadmium is normal
Cosmetics often can be brought into as impurity, especially in some facial treatment milk, cream, it is difficult to accomplish to be entirely free of cadmium.So
Background under, it is being issued by state food pharmaceuticals administration general bureau in December, 2015 and have been carried out in December, 2016
《Cosmetics safety technical specification》The limit value of cadmium is increased, it is domestic at present there was only standard liquid containing cadmium, also without related containing cadmium
Emulsus class standard material, when sample is emulsus matrix, is made using the cadmium standard liquid for having bigger difference with emulsus matrix
It is control, systematic error can be introduced, influences the accuracy for determining, therefore emulsus class cosmetic standard of the research containing heavy metal cadmium
Material, it is all significant to improving Cosmetic Manufacture, cosmetics supervision and detection management work standardization etc..
The content of the invention
It is an object of the invention to provide the preparation method of the emulsus class cosmetic standard material containing heavy metal cadmium, its bag
Contain：Emulsus class cosmetic base, and heavy metal cadmium is dispersed in the emulsus class cosmetic base, and uniformity and steady
It is qualitative to reach national grade ii standard material requirement.
The present invention is the emulsus class cosmetic standard material containing heavy metal cadmium, with emulsus class cosmetics Matrix Match degree
Height, testing result has more reliability and accuracy.Sample preparation raw material is easy to get, method is simple, reliable and stable, success rate is high, can
It is repeated strong, with good uniformity and stability.
The technical solution used in the present invention is：A kind of preparation of the emulsus class cosmetic standard material containing heavy metal cadmium
Method, conjunction is mixed with water by the oil phase in emulsus class cosmetics, forms emulsus class cosmetics, then adds cadmium-containing solution wherein,
Form the emulsus class cosmetic standard material containing heavy metal cadmium.
Above-mentioned emulsus class cosmetic formulations are included by mass percentage：
A phases：Cetostearyl alcohol 2 ~ 4, stearine 1 ~ 3, Dormant oils（White oil 15#）4 ~ 6, dimethyl silicone polymer 2 ~ 5, palm
Isopropyl propionate 1 ~ 3, stereth -2（72）1 ~ 2.5, Nipasol 0.05 ~ 0.1；
B phases：Water 62 ~ 82.75, glycerine 3 ~ 6, propane diols 1 ~ 4, stereth -21（721）2 ~ 3.5, xanthans 0.1 ~ 0.2,
Methyl hydroxybenzoate 0.1 ~ 0.2；
C phases：Standard liquid containing cadmium 0 ~ 0.5.
On the basis of above-mentioned emulsus class cosmetic base, preparation method comprises the steps：
The first step：B phase raw material xanthans is accurately weighed in advance, it is dispersed, be dissolved in water it is stand-by.
Second step：Each raw material of A phases is accurately weighed respectively, is added in oil phase tank, be slowly heated to 80 DEG C, it is stand-by.
3rd step：Each raw material of B phases is accurately weighed respectively, is added in scattered xanthan gum solution in advance, added in the lump
In water phase tank, 80 DEG C are slowly heated to, it is stand-by.
4th step：The stirring of emulsion tank is opened, under vacuum conditions, A phases is first added, after adding B phases, stirred.
5th step：Homogeneous is opened, 80 DEG C of keeping temperature, homogeneous 5 minutes after homogeneous terminates, opens stirring, and emulsion tank continues
Insulation 30 minutes.
6th step：Slowly lower the temperature, when being cooled to 45 DEG C~50 DEG C, add C phase standard liquids containing cadmium, homogeneous 3 minutes.
7th step：When temperature is down to room temperature, stop stirring, the inspection of semifinished product, it is qualified after, discharging, it is filling, that is, be made and contain
There are the emulsus class cosmetics of heavy metal cadmium.
The present invention mixes heavy metal cadmium with emulsus class cosmetic emulsion, forms the emulsus class cosmetics containing heavy metal cadmium
Standard substance, the standard substance with it is actually detected when the cosmetic sample matrix matching degree containing heavy metal it is high so that right
The testing result of emulsus class Heavy Metals in Cosmetics has more reliability and accuracy.
Specific embodiment
The preparation method of the emulsus class cosmetic standard material containing heavy metal cadmium：By the oil phase in emulsus class cosmetics and
Water is mixed, and forms emulsus class cosmetics, then adds cadmium-containing solution wherein, forms the emulsus class cosmetics containing heavy metal cadmium
Standard substance.
The emulsus class cosmetic standard material formula containing heavy metal cadmium is as shown in the table by mass percentage：
Emulsus class cosmetic standard substances preparation method containing heavy metal cadmium：
The first step：B phase raw material xanthans is accurately weighed in advance, it is dispersed, be dissolved in water it is stand-by.
Second step：Each raw material of A phases is accurately weighed respectively, is added in oil phase tank, be slowly heated to 80 DEG C, it is stand-by.
3rd step：Each raw material of B phases is accurately weighed respectively, is added in scattered xanthan gum solution in advance, added in the lump
In water phase tank, 80 DEG C are slowly heated to, it is stand-by.
4th step：Emulsion tank is opened, under vacuum conditions, A phases is first added, after adding B phases, stirred.
5th step：Homogeneous is opened, 80 DEG C of keeping temperature, homogeneous 5 minutes after homogeneous terminates, opens stirring, and emulsion tank continues
Insulation 30 minutes.
6th step：Slowly lower the temperature, when being cooled to 45 DEG C~50 DEG C, add C phase solution, homogeneous 3 minutes.
7th step：When temperature is down to room temperature, stop stirring, the inspection of semifinished product, it is qualified after, discharging, it is filling, that is, be made and contain
There are the emulsus class cosmetics of heavy metal cadmium.
Using inductively coupled plasma mass spectrometry, the emulsus class cosmetics containing heavy metal cadmium obtained in the above method are entered
Row test：
1st, uniformity test：Randomly select 15 bottles of samples, every bottle of independently sampling 2 times, test result such as following table：
By variance analysis, F is obtainedCalculate＜ F0.05(14,15), show that sample is uniform.
2nd, stability test：In 6 months, test sample 3 times, 3 bottles of each grab sample, independently sample 2 every time respectively
Secondary, test result see the table below：
Investigated by 6 months to sample, test result becomes in method of testing range of uncertainty without obvious directionality
Change, sample stabilization.
Data above shows the emulsus class cosmetic standard thing containing heavy metal cadmium through China National Measuring Science Research Inst.'s detection
Matter uniform stabilization within the time period of monitoring half a year, reaches the requirement of national grade ii standard thing.
New and consulting is looked into through ISTIC Research ＆ Traning Center's Access point center, the series standard material is adapted to
What the end of the year 2016 just implemented《Cosmetics safety technical specification》New demand to skin-protection product.
Claims (2)
1. a kind of preparation method of the emulsus class cosmetic standard material containing heavy metal cadmium, it is characterised in that：By cadmium-containing solution
It is dispersed in emulsus class cosmetic base, forms the standard substance for detecting emulsus class Heavy Metals in Cosmetics cadmium, its
In, the formula of the cosmetic emulsion is by mass percentage：
A phases
Cetostearyl alcohol 2 ~ 4
Stearine 1 ~ 3
Dormant oils（White oil 15#） 4~6
Dimethyl silicone polymer 2 ~ 5
Isopropyl palmitate 1 ~ 3
Stereth -2（72） 1~2.5
Nipasol 0.05 ~ 0.1
B phases
Glycerine 3 ~ 6
Propane diols 1 ~ 4
Stereth -21（721） 2~3.5
Xanthans 0.1 ~ 0.2
Methyl hydroxybenzoate 0.1 ~ 0.2
Water 62 ~ 82.75
C phases
Standard liquid containing cadmium 0 ~ 0.5.
2. the preparation method of a kind of emulsus class cosmetic standard material containing heavy metal cadmium according to claim 1, its
It is characterised by：The preparation method of emulsus class cosmetics comprises the steps：
The first step：B phase raw material xanthans is accurately weighed in advance, it is dispersed, be dissolved in water it is stand-by；
Second step：Each raw material of A phases is accurately weighed respectively, is added in oil phase tank, be slowly heated to 80 DEG C, it is stand-by；
3rd step：Each raw material of B phases is accurately weighed respectively, is added in scattered xanthan gum solution in advance, water phase is added in the lump
In tank, 80 DEG C are slowly heated to, it is stand-by；
4th step：The stirring of emulsion tank is opened, under vacuum conditions, A phases is first added, after adding B phases, stirred；
5th step：Homogeneous is opened, 80 DEG C of keeping temperature, homogeneous 5 minutes after homogeneous terminates, opens stirring, and emulsion tank continues to be incubated
30 minutes；
6th step：Slowly lower the temperature, when being cooled to 45 DEG C~50 DEG C, add C phase standard liquids containing cadmium, homogeneous 3 minutes；
7th step：When temperature is down to room temperature, stop stirring, the inspection of semifinished product, it is qualified after, discharging, it is filling, that is, be made containing weigh
The emulsus class cosmetics of cadmium metal.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710037151.8A CN106908576A (en) | 2017-01-19 | 2017-01-19 | Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof |
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| CN201710037151.8A CN106908576A (en) | 2017-01-19 | 2017-01-19 | Emulsus class cosmetic standard material containing heavy metal cadmium and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111965284A (en) * | 2020-08-20 | 2020-11-20 | 中检科（北京）实验室能力评价有限公司 | Dioxane-containing cosmetic emulsion matrix standard sample and preparation method thereof |
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|---|---|---|---|---|
| CN101936835A (en) * | 2010-09-03 | 2011-01-05 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting scurf removing agent in cosmetics |
| CN102353572A (en) * | 2011-06-30 | 2012-02-15 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard material for detecting ferulic acid in cosmetics |
| CN102944652A (en) * | 2012-12-10 | 2013-02-27 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard substance for detecting aristolochic acid A in cosmetic |
| CN102944654A (en) * | 2012-12-12 | 2013-02-27 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard substance for detecting arecoline in cosmetic |
-
2017
- 2017-01-19 CN CN201710037151.8A patent/CN106908576A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101936835A (en) * | 2010-09-03 | 2011-01-05 | 上海相宜本草化妆品有限公司 | Method for preparing standard substance for detecting scurf removing agent in cosmetics |
| CN102353572A (en) * | 2011-06-30 | 2012-02-15 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard material for detecting ferulic acid in cosmetics |
| CN102944652A (en) * | 2012-12-10 | 2013-02-27 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard substance for detecting aristolochic acid A in cosmetic |
| CN102944654A (en) * | 2012-12-12 | 2013-02-27 | 上海相宜本草化妆品股份有限公司 | Preparation method of standard substance for detecting arecoline in cosmetic |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111965284A (en) * | 2020-08-20 | 2020-11-20 | 中检科（北京）实验室能力评价有限公司 | Dioxane-containing cosmetic emulsion matrix standard sample and preparation method thereof |
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Application publication date: 20170630 |