CN106908297A - Forming devices and the method moulding to tissue specimen for tissue specimen - Google Patents
Forming devices and the method moulding to tissue specimen for tissue specimen Download PDFInfo
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- CN106908297A CN106908297A CN201710262455.4A CN201710262455A CN106908297A CN 106908297 A CN106908297 A CN 106908297A CN 201710262455 A CN201710262455 A CN 201710262455A CN 106908297 A CN106908297 A CN 106908297A
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- tissue specimen
- clamping element
- clamp assembly
- forming devices
- pedestal
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of forming devices for tissue specimen.The forming devices include pedestal, first clamp assembly and the second clamp assembly, wherein, first and second clamp assemblies are respectively provided with clamping element, lower clamping element and keeper, on, lower clamping element can be together with keeper along guide part horizontal movement, upper clamping element and corresponding lower clamping element energy relative motion, so that forming gap between them, the recess of circle is provided with pedestal, round turntable can be rotated to support in recess, the round turntable is used to carry the carrier for tissue specimen, clamping element and corresponding lower clamping element have outwardly open rim openings at least one, wherein, their rim openings are arranged to consistency from top to bottom, to allow fixture to pass through.In addition, the invention also discloses a kind of for the method moulding to tissue specimen.
Description
Technical field
The present invention relates to a kind of forming devices for tissue specimen and a kind of method moulding to tissue specimen.
Background technology
With developing rapidly for endoscopic technic, Endoscopic Treatment is more and more, and the judgement to scope therapeutic effect is then led
To depend on the pathological diagnosis of pathological tissues sample and whether there is complication, wherein the pathological diagnosis of pathological tissues sample are extremely closed
Important, its prognosis treatment to disease has important directive significance.Especially for the endoscopic excision treatment of tumor in digestive tract,
The lateral incision edge and substrate incisxal edge of the pathological tissues sample of excision have the remnants of negative for tumor cells, may determine whether to need scope again
Treatment, or even surgical operation therapy.Therefore a good pathologic group is prepared by the treatment of the pathological tissues sample to cutting off
Knit section most important.The materials of the preparation process of histopathologic slide including tissue specimen, fixation, dehydration, embedding, freezing,
Section, dyeing etc., and the fixation of tissue specimen is often the key factor for influenceing pathological diagnosis or experimental result.
During medical basic research and Clinicopathologic Diagnosis, researcher not only needs to pay close attention to pathological tissues cell sheet
The information of body, while being also required to understand the relation and perilesional area and normally of position and global tissue or organ where lesion
The morphologic information and evolution Feature of regional organization's cell.It is to the conventional method that tissue specimen carries out pathology treatment before dehydration
Be directly placed into or first pass through simple fixed pin pre-fix general form place into it is fixed in neutral formalin solution, it is and right
For some tissue specimens, the mucous membrane or organ especially rich in moisture and dense connective tissue, in fixation procedure due to
Asymmetric contraction is organized, sample surface shrinkage, curling, deformation and incisxal edge is occurred not whole.Additionally, tissue specimen is by de-
After water process, quality is relatively brittle, and profile is more irregular.This will have influence on observation of the researcher to pathological tissues cell,
Cause Error Diagnostics.Therefore, tissue specimen is carried out before fixed effective early stage process, it is i.e. moulding, can not only reduce section
When to the waste of sample and reduce the physical demands of operating personnel, and can to a greater degree keep the original of pathological tissues sample
Shape, present completely and exactly the general form and microstructure of tissue specimen, the form of diseased region and its surrounding, structure and
The information such as neighbouring relationship.
Traditional tissue specimen is moulding, and for example mucosal tissue is moulding, mainly by simple pin of fixing by tissue specimen
It is fixed on carrier such as cystosepiment, maintains the general form of pathological tissues.But the defect of this method is manually-operated process
In by putting the fixed fixation so as to realize total preparation one by one, it is impossible to ensure that sample is fixed on carrier with being uniformly tensioned
On, cannot more ensure pathological tissues incisxal edge and surface it is smooth.There is table by after fixation, dewater treatment, usually making sample
Face shrinkage, curling, deformation and incisxal edge be not whole.Another defect is, tissue specimen is fixed after pin fixes, its lower surface and load
Show consideration for and close tight so that fixer can not fully infiltrate tissue specimen, so as to influence the moulding effect of sample.Above mentioned problem all may be used
The precision of the pathological diagnosis of tissue specimen can be directly influenced.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of for the forming devices of tissue specimen and for right
The moulding method of tissue specimen so that the original state of tissue specimen can to a greater degree be presented in pathological observation, reduces diagnosis
Error.
In the present invention, above-mentioned task is solved using a kind of forming devices for tissue specimen.
According to the present invention, the forming devices include pedestal, the first clamp assembly and the second clamp assembly, wherein, it is described
First clamp assembly and the second clamp assembly are respectively provided with clamping element, lower clamping element and keeper, and the upper clamping element is with
Clamping element can be together with keeper along the guide part horizontal movement being arranged in pedestal, the upper clamping element and corresponding lower folder
Tight part energy relative motion so that form the gap for accommodating tissue specimen between them, is provided with the recessed of circle in pedestal
Portion, round turntable can be rotated to support in the recess of pedestal, and the round turntable is used to carry the carrier for tissue specimen, extremely
A few upper clamping element and corresponding lower clamping element have outwardly open rim openings, wherein, on described at least one
The rim openings of clamping element and corresponding lower clamping element are arranged to consistency from top to bottom, to allow fixture to pass through.The present invention the
The clamping element up and down of one clamp assembly and the second clamp assembly can provide uniform clamping force to tissue specimen edge, realize group
Knit the uniform fixation at sample edge, coordinate that keeper is micro along foot guide portion and accurate horizontal movement can be realized to marking
The accurate effective uniform tensioning of this tissue.Can not only make operation more convenient by setting round turntable, can more realize to various
Tissue specimen of different shapes is moulding any edge side, it is most important that the cooperation with rim openings can be realized to tissue
Uniform tensioning effect of sample edge side.In addition, rim openings of the invention are pressed by setting, even if realizing in clamp assembly
In the case that clamping is compared with broad edge, also ensures that and be fixed using fixed pin in tissue specimen edge far-end as far as possible,
Thus, it is possible to the original state for keeping materials to organize to a greater degree, the general form and microcosmic knot of tissue specimen are presented completely and exactly
Structure.Rim openings design can also make the first clamp assembly in the case where tissue specimen fixed effect and solid form is not influenceed
And second clamp assembly easily release clamping to tissue specimen.
A kind of preferred scheme of the invention, the lower clamping element of first clamp assembly and second clamp assembly
Lower clamping element be located on pedestal upper surface identical height.Therefore ensure that tissue specimen can be with water in the case of tensioning
Level land is maintained between the first clamp assembly and the second clamp assembly.Meanwhile, it is lower that certain distance is kept between clamping element and pedestal,
Fixation of not fitted between tissue specimen and carrier can be made, kept at a distance can not only avoid by carrier that out-of-flatness is made in itself therebetween
Into to the moulding effect detrimental effect of tissue specimen, also help fixer abundant infiltration comprehensive to tissue specimen, make group
Sample is knitted to fix evenly, it is moulding better.
A kind of preferred scheme of the invention, is provided with regulating element on pedestal, is performed by means of the regulating element
The horizontal movement of first clamp assembly and the second clamp assembly relative to pedestal.Thus, it is possible to realize and its slow speed pair
The horizontal movement of clamp assembly is adjusted, and such as regulating element is often rotated one week, and the amount of feeding of clamp assembly is less than 1mm.By
This ensures the moulding precision to tissue specimen.
A kind of preferred scheme of the invention, the horizontal movement of first clamp assembly and the second clamp assembly also can
Realized by the direct push-and-pull of operating personnel.Thus, it is possible to realize：Forward direction tissue specimen of the clamp assembly in grip tissue sample
Feed motion or release clamp after away from tissue specimen away from motion can quickly carry out so that when saving operation
Between, improve the moulding efficiency to tissue specimen.
A kind of preferred scheme of the invention, first clamp assembly and/or second clamp assembly have arc
The front end face of shape.This is particularly advantageous when carrying out moulding to the tissue specimen with curved edge, can make tissue specimen
Curved edge tensioning is evenly smooth, effectively prevents curling.
A kind of preferred scheme of the invention, the upper clamping element and the lower clamping element can individually in support
Upper vertical motion.Thus, each clamping element can be equipped with an adjustment mechanism so that the control to clamping element is cleverer
It is living.
A kind of preferred scheme of the invention, the round turntable is supported on pedestal with its support by means of bearing
Coordinate on support.Thus, the horizontal rotation to tissue specimen is realized in a kind of simple and reliable mode.
Also asked for solving technology of the present invention to the moulding method of tissue specimen by means of a kind of in the present invention
Topic.Specific method step is as follows：
A) will be fixed for the carrier of tissue specimen；
B) edge side of tissue specimen is clamped；
C) the opposed other edge side of tissue specimen is clamped；
D) tissue specimen is tensioned；
E) the above-mentioned two edge side of tissue specimen is fixed on carrier using fixture；
F) clamping to tissue specimen is released；
G) make tissue specimen horizontal rotation and repeat step b) is to f)；And
H) moulding tissue specimen will have been completed to be taken out together with carrier.
Preferably, the fixation to carrier in step a) is realized by the fastener set on round turntable.Thus, with
A kind of simple and effective way realizes the fixation to carrier.
The above method can be realized using forming devices of the present invention.
Brief description of the drawings
The present invention is explained in detail below by way of accompanying drawing.In the accompanying drawings：
Fig. 1 schematically shows the front view according to forming devices of the invention；
Fig. 2 schematically shows the top view according to forming devices of the invention；
Fig. 3 is schematically shown according to a kind of flexible program of forming devices of the invention；
Fig. 4 schematically shows the state in tension tissue sample according to Fig. 3 forming devices.
Specific embodiment
Fig. 1 and Fig. 2 are shown respectively according to the front view and top view of forming devices of the invention 1, wherein, mould in Fig. 1
The part that shape dress is put is illustrated with section view.The forming devices 1 include pedestal 2, clamp assembly 3 and clamp assembly 4.Clamp assembly
3 and clamp assembly 4 can be configured to identical, and be preferably oppositely arranged on the same line.Here, clamp assembly 3
With keeper 8, upper clamping element 31 and lower clamping element 32, and clamp assembly 4 has keeper 9, upper clamping element 41 and lower clamping
Part 42.Clamp assembly 3 and clamp assembly 4 can keep horizontal movement on the base 2 with its keeper 8,9, wherein, the level fortune
It is dynamic to be realized via the guide part 6 (referring to Fig. 2) set in pedestal.The guide part 6 is any of achievable guide effect
Structure, such as linear pattern groove or projection cube structure, are designed using groove in the present embodiment, and keeper 8,9 can do past along the groove
Multiple motion.In addition, upper clamping element 31,41 and corresponding lower clamping element 32,42 can be movable relatively so that in two mating reactions
The gap for accommodating tissue specimen 20 is formed between clamping element.
Clamp assembly 3,4 can be structured as traditional ticket-holder structure, so that upper clamping element 31,41 and corresponding lower clamping element
32nd, 42 can be moved around a common pivot axis, to open clamp assembly 3,4 or to close up.Under this kind of structure,
Clamp assembly is vertically movable without making, and keeper can be integrally formed formation " folder tail " structure on the downside of lower clamping element, so that
Operating personnel can easily operate " folder tail " to realize opening and closing up for upper and lower clamping element.Preferably, upper clamping element is with
Clamping element is also designed to separate type so that upper clamping element and lower clamping element can be along the in the vertical directions of keeper 8
Move toward one another or away from motion, such as the two do up-and-down movement along the gathering sill of same keeper 8, so as to realize clamp assembly
Open or close up.Advantageously, only going up clamping element can be with vertical motion, and lower clamping element cannot be vertically movable, and two
Individual lower clamping element 32,42 is on pedestal upper surface identical height, and the height is preferred for 2mm~5mm, specific height
Can actually be adjusted according to thickness of tissue specimen etc..To ensure that tissue specimen 20 can flatly be maintained in the state of clamping
Between clamp assembly 3 and clamp assembly 4.Clamping element and each lower clamping element are respectively provided with two outwardly open edges on each
The rim openings 10 of opening 10, each upper clamping element and corresponding lower clamping element are arranged in up and down alignment, solid to allow
Determine part 11 tissue specimen 20 is fixed on carrier 5 through clamp assembly 3,4, fixture 11 can be followed closely for fixed.Here, also may be used
Capable, the upper clamping element of each clamp assembly and lower clamping element have only one rim openings or with more than two respectively
Rim openings, or the upper clamping element and lower clamping element of only one clamp assembly have rim openings 10.
The recess 14 of circle is provided with pedestal 2, a round turntable 13 is accommodated in recess 14, the round turntable 13
In can be rotated to support on the recess 14 of pedestal, and the round turntable is used to carry the carrier 5 for tissue specimen.By Fig. 1
In Cut-away section it is clearly visible, round turntable 13 is supported on pedestal with its support 15 by means of bearing 12 in the present embodiment
On 2 cooperation support 16.The fastener (not shown) set on round turntable 13, the purpose of the fastener is realized to carrying
The spacing fixation of body 5, can using in the prior art any one can realize the structure of the purpose, such as spacing preiection and groove
Coordinate etc..But because the recess 14 for having circle is present, the form of carrier 5 is often designed as the shape matched with the recess 14,
Therefore it is also feasible that fastener is not provided with round turntable 13, and carrier 5 is naturally limited in recess 14, prevents it from taking off
Go out.
In addition, on the base 2, being especially provided with regulating element 7, such as operating personnel, medical matters people on the lateral wall of pedestal
Member can perform horizontal movement of the clamp assembly 3,4 relative to pedestal 2 by means of the regulating element 7.Preferably, in regulating element
Gear worm deceleration device is provided between 7 and corresponding clamp assembly 3,4 so that can be with to the horizontal adjustment of clamp assembly
Slowly speed is carefully carried out.Certainly, it is also contemplated that be not provided with the embodiment of regulating element 7, in the implementation
In scheme operating personnel can the keeper 8,9 of direct gripping clip component clamp assembly is moved in guide portion 6 by push-and-pull.
It is particularly preferred that the horizontal movement of clamp assembly can not only be realized by the direct push-and-pull of operating personnel, also can be via regulation unit
Part 7 is realized.In addition, in the clamping element of separation design, the opening movement of upper clamping element and lower clamping element also can be by means of phase
The regulating element being separately provided answered is realized.
Fig. 3 is shown according to a kind of flexible program of forming devices of the invention 1.In this scenario, clamp assembly 3 and clamping
Component 4 has a front end face 17 for arc respectively, i.e. upper clamping element 31,41 and lower clamping element 32,42 have an arc respectively
The front end face of shape.This design of clamp assembly is particularly well-suited to the tissue specimen with curved edge.Certainly, only one is clamped
It is also feasible that component has the front end face of arc, and being so more suitable for existing curved edge also has the tissue of other broken edges
Sample.It is more full and uniform that this kind of structure design can be tensioned tissue specimen edge, it is also possible to tissue specimen edge distalmost end
Realize that tensioning uniform as far as possible is fixed.In addition, it is also contemplated that clamping device has other shapes of front end face, to adapt to
A variety of edges of tissue sample.
As shown in figure 4, medical worker can as follows to group in the case of using by forming devices of the invention 1
Knitting sample 20, especially mucosal tissue carries out moulding, comprises the following steps that：
A) will be fixed for the carrier 5 of tissue specimen 20.For example, carrier 5 (such as cystosepiment or tinfoil paper) is placed and solid
It is scheduled on the round turntable 13 of forming devices 1, it is preferable that the fastener reality that the fixation passes through the setting on round turntable 13
It is existing.
B) edge side of tissue specimen 20 is clamped.Its mode is, for example, first to make clamp assembly 3 towards tissue specimen
Suitable position is moved to, then an edge side of tissue specimen 20 is clamped between upper clamping element 31 and lower clamping element 32.
C) the opposed other edge side of tissue specimen 20 is clamped.The step can be achieved in that：Clamp assembly 4 is set to exist
The top of carrier 5 is towards the horizontal movement of clamp assembly 3, until clamp assembly 4 can clamp the other edge side of tissue specimen.
D) it is tensioned tissue specimen 20.Its concrete mode can be：By means of regulating element 7 or Manual push-pull clamp assembly
4 and clamp assembly 3, clamp assembly 4 is moved away from clamp assembly 3, until tissue specimen reaches desired tension force.
E) the above-mentioned two edge side of tissue specimen is fixed on carrier 5 using fixture.Its concrete mode can be：
Using fixture 11 (being represented with round dot in fig. 4), for example fix pin or fixed nail through upper clamping element 31,41 and lower clamping element
32nd, be fixed on carrier at tissue specimen edge by 42 each rim openings 10, here, because tissue specimen is spaced apart one with carrier
Set a distance, can also further reduce being brought not because carrier out-of-flatness is moulding to tissue specimen of existing in the prior art
Profit influence, and tissue specimen can be made fully to be infiltrated in the treatment of later stage fixer, prevent tissue specimen moulding insufficient.
F) clamping to tissue specimen 20 is released.Clamp assembly 3,4 is opened and makes clamp assembly 3,4 away from tissue specimen
Motion, due to the design of rim openings 10, can easily discharge the edge side of tissue specimen while fixed effect is not influenceed.
G) make the horizontal rotation of tissue specimen 20 and repeat step b) is to e).Make carrier disposed thereon 5 using round turntable 13
An angle for determination is horizontally rotated together with tissue specimen, so that other edge sides of tissue specimen are fixed on carrier, no
It is disconnected to repeat the above steps, until there are enough edge sides to be fixed on carrier, so as to complete the uniform tensioning to tissue specimen
It is moulding.
H) moulding tissue specimen 20 will have been completed to be taken out together with carrier 5.Its concrete mode can be：Group will be clamped
Part 3,4 opens and clamp assembly 3,4 is moved distance remote enough away from tissue specimen, so as to the tissue mark that will be fixed together
This and carrier together take out.
The embodiment has shown or described possible embodiment of the invention, wherein, here, it is noted that each list
The mutual various various combinations of individual embodiment are also feasible.
For the sake of for specification, finally, it is noted that in order that the structure of forming devices 1 is it can be readily appreciated that the forming devices
Part shows not to scale and/or enlargedly and/or with reducing.
Claims (10)
1. a kind of forming devices for tissue specimen, it is characterised in that the forming devices (1) include pedestal (2), the first folder
Tight component (3) and the second clamp assembly (4), wherein, first clamp assembly (3) and the second clamp assembly (4) are respectively provided with
Clamping element (31,41), lower clamping element (32,42) and keeper (8,9),
The upper clamping element (31,41) and lower clamping element (32,42) can be together with keepers (8,9) along being arranged on pedestal (2)
In guide part (6) horizontal movement,
The upper clamping element (31,32) and corresponding lower clamping element (41,42) energy relative motion so that formed use between them
In the gap for accommodating tissue specimen (20),
The recess (14) of circle is provided with pedestal (2), round turntable (13) can be rotated to support in the recess (14) of pedestal,
The round turntable is used to carry the carrier (5) for tissue specimen (20),
Clamping element and corresponding lower clamping element have outwardly open rim openings (10) at least one, wherein, it is described
The rim openings (10) of clamping element and corresponding lower clamping element are arranged to consistency from top to bottom at least one, to allow fixture
(11) pass through.
2. forming devices as claimed in claim 1, it is characterised in that the lower clamping element of first clamp assembly (3) and institute
The lower clamping element for stating the second clamp assembly (4) is located on pedestal upper surface identical height.
3. forming devices as claimed in claim 1, it is characterised in that regulating element (7) is provided with pedestal (2), by
The horizontal movement of the first clamp assembly and the second clamp assembly relative to pedestal (2) is performed in the regulating element (7).
4. forming devices as described in claim 1 or 3, it is characterised in that first clamp assembly and the second clamp assembly
Horizontal movement can also be realized by the direct push-and-pull of operating personnel.
5. forming devices as described in one of claims 1 to 3, it is characterised in that first clamp assembly (3) and/or institute
State front end face (17) of the second clamp assembly (4) with arc.
6. forming devices as described in one of claims 1 to 3, it is characterised in that the upper clamping element (31,41) and it is described under
Clamping element (32,42) can be individually vertically movable on support (8).
7. forming devices as described in one of claims 1 to 3, it is characterised in that the round turntable (13) is with its support
(15) it is supported on the cooperation support (16) of pedestal (2) by means of bearing (12).
8. it is a kind of for the method moulding to tissue specimen, it is characterised in that to comprise the following steps：
A) carrier (5) that will be used for tissue specimen (20) is fixed；
B) edge side of tissue specimen (20) is clamped；
C) the opposed other edge side of tissue specimen (20) is clamped；
D) tissue specimen (20) is tensioned；
E) the above-mentioned two edge side of tissue specimen is fixed on carrier (5) using fixture；
F) clamping to tissue specimen (20) is released；
G) tissue specimen (20) is made to horizontally rotate and step b) to f is repeated several times)；And
H) moulding tissue specimen (20) will have been completed to be taken out together with carrier (5).
9. method as claimed in claim 8, it is characterised in that the fixation to carrier (5) in step a) turns by circle
The fastener set on platform (13) is realized.
10. method as claimed in claim 8, it is characterised in that using according to the described moulding dress of one of claim 1 to 7
It is described for the method moulding to tissue specimen (20) to implement to put (1).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710262455.4A CN106908297B (en) | 2017-04-20 | 2017-04-20 | Shaping device for tissue specimens and method for shaping tissue specimens |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710262455.4A CN106908297B (en) | 2017-04-20 | 2017-04-20 | Shaping device for tissue specimens and method for shaping tissue specimens |
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| CN106908297B CN106908297B (en) | 2023-06-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114403124A (en) * | 2022-01-23 | 2022-04-29 | 西南林业大学 | Novel ant specimen manufacturing device |
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