CN106901729A - A kind of medication coat for backbone reduction system - Google Patents

Abstract

A kind of medication coat used in backbone reduction device, the backbone reduction system is treated for the slight contracture of muscle caused by the reasons such as modern's bad life habits and disease and muscle tonue.Muscular tone mostly occurs and adhere to or associate on muscle group in backbone both sides, and long will cause the even deformation of backbone fatigue, overload.It is proved to be effective treatment means by applying the alleviation muscle tonue such as machinery, electric field while spinal traction, fixation is implemented in spine recovering field.The present invention provides various treatment means, and is effectively combined electricity, magnetic treatment.By human body muscle tonue related neural section induced discharge, various muscle health indexs are improved effectively；Adaptivity adjustment is carried out in real time in combination with checking with EMG method to obtain better healing effect.The discomfort that adding medicine composition of the present invention in above process can effectively alleviate during Neural stem cell is felt and is that physiotherapy increases medication effect.

Description

A kind of medication coat for backbone reduction system

Technical field

The application is related to spine recovering field, and in particular to the convalescence device of a kind of backbone and muscle.

Background technology

Modern causes body a part to be chronically at due to seat work, bad life habits and disease or certain reason Anchor, muscle is chronically at the state of underload contracts last.Moisture subtracts during this can cause the fibr tissue matrix such as ligament Few, viscoelasticity weakens, interfibrous lubrication reduction.Meanwhile, interfibrous hypotelorism, the extension of contact phase, this may lead Chemical horizontal key is produced between causing fiber, so as to cause to be sticked together between fiber.And such crowd is often because of the chronic inflammation of muscular tissue Disease and cause the fiber of new life, these newborn fiber alignments are disorderly, and adhesion is formed again with original fiber, further limit fibre Slip between dimension.Long it, this " vicious circle " will cause muscle that slight contracture occurs, and cause muscle tonue.The life of modern Mode living determines that such muscle tonue is mostly occurred on backbone attachment or sizes related muscle group, and long will cause backbone tired The appearance of labor, overload or even irreversible damage.

Implementing spinal traction, fixation simultaneously by applying the alleviation muscle tonue quilt such as machinery, electric field in spine recovering field Prove effective treatment means.But the unnecessary damage of backbone is inevitably caused during being somebody's turn to do, or even meeting (spinal cord injury, SCI) is damaged to spinal cord, and medical personnel often is reluctant to adopt in order to avoid the damage With positive therapeutic scheme.Also often there is unexpected massage in the massage processes that non-spinal is damaged simultaneously to damage.So When spinal treatments are related to, needs provide effectively real-time electrophysiologic monitoring means.How electro physiology to be detected and various backbone health It is a direction that this area has much development prospect that multiple means combine.Generation is obtained effectively and had in numerous electrophysiological indexs The data of table, and with the follow-up spine recovering of guidance carrying out, be also this area research emphasis.

Neuro electromyograph is that, according to Nervous System Anatomy principle, the energy by diversified forms stimulates, to organism The biological electricity that peripheral nerve is produced and the technology that the electrical characteristics of organism are measured, record and analyzed.Evoked ptential (evoked Potentials, EPs), refer to give nervous system (from receptor to cerebral cortex) specifically to stimulate (sound, light or body-sensing thorn Swash), or brain is processed the information for stimulating (positivity or negativity), produce and can examine in the corresponding site of the system and brain The biological electricity for being relatively fixed time interval (relation during lock) and certain bits phase that has with stimulation for going out reacts.It reflects cynapse biography Pass, axon conduction cell and molecular system structure and function integrality, be a kind of effective its functional attributes.

Electromyographic signal (EMG) is a kind of bioelectrical signals produced with muscular movement.In the limb motion of people, greatly The neuronal excitation of moving region is controlled in cortex and the electric pulse of certain frequency is produced, this electric pulse passes through nervous system Specific meat fiber is accurately conducted, when these electric pulses reach neural muscle cynapse, soleplate is produced in muscle fibre Current potential, its depolarising will produce a series of movements current potential in muscle fibre, cause contraction of muscle, limbs is completed set by brain Action.Surface EMG is the comprehensive physiology electrical phenomena that each several part muscle activity is generated in limb motion, and surface EMG is divided Analysis research can find its corresponding relation and muscle physiological state and limb motion patterns between, can be widely applied to clinical doctor The numerous areas such as, sports medical science, medical rehabilitation.In human skeletal muscle, there is Severe Pain point in muscle muscle tonue band The viewpoint of (myofascial trigger point, MTrP) is widely recognized as.Can be recorded in the MTrP areas of muscle tonue band To spontaneous electrical activity, further, muscular tone also can be showed and be detected in the form of myoelectricity.Flesh in simple terms Meat makes expression by electricity physiological signal to its physiological status (stressing myotonic physiological status in the present invention to state)；In turn Appropriate regulation can also be made to muscle tonue by way of impressed field influences myoelectricity.

Exist in the prior art by patient carrying out electro photoluminescence and receiving the myoelectricity/biofeedback signals of patient, so that Reach the method and apparatus for improving muscular tone.But these devices use simple electrode stimulating, frequency be located substantially at 5Hz~ Between 100Hz, electric signal is simple comprising waveform.It is single to the effect of stimulation of human body, be easily caused peripheral nerve fatigue and produce Raw a large amount of unnecessary electrode heat.Insertion electrode or patch electrode may then cause skin keratin lesion and bring unnecessary damage Wound.Patient can produce the unnecessary imagination, this kind of psychology to also result in therapeutic effect deterioration for visible electrode stimulating directly perceived. Above all peripheral nerve may react good for short-term stimulation, but long-term treatment can cause neural fatigue, effect also can It is plummeted.Reason is that human nerve stress reflect for the injury that environmental stimuli is produced and have one to adapt in evolutionary process Journey.And such fatigue is then less prone to including the human body self neural electricity including neuromere, its fatigue endurance phase is longer in other words.

Neuromere be function identical neuron cell body beyond the maincenter around position set nodositas structure Make.Its surface is surrounded by one layer of connective tissue membrane, wherein containing blood vessel, nerve and fat cell.Envelope and perineural adventitia, god Connected together through beam film, and go deep into neuromere forming the network in neuromere.The fiber sent by nerve cell in section The relevant part of body is distributed to, claims postganglionic fibers.By physiology and the difference of form, neuromere can be spinal ganglion (sensibility god Warp knuckle) and the class of automatic ganglia two.Cerebrospinal ganglion functionally belongs to sensory neuron, morphologically belong to false monopole or Bipolar neuron.Automatic ganglia includes sympathetic and parasympathetic ganglion.Sympathetic ganglion is located at backbone both sides.Parasympathetic god Warp knuckle is located in the vicinity of institute's dominating organs or organ walls.In neuromere, aixs cylinder and the postganglionic neuron group of preganglionic neuron Into cynapse.Neuromere is associated by nerve fibre with brain, spinal cord.

Inventor is tested by the physiology that laboratory is carried out and found：Led including the nervous system including neuromere by stimulating The biological electricity for causing human body to produce is inaccurate controllable in amplitude, frequency, and the biological electricity helps lend some impetus to nerve and controls muscle, knot Forming tissue has rhythm and pace of moving things ground diastole, contraction and the blood circulation of tip fine vascular.To also be led for ganglionic stimulation simultaneously Effect of the ascending nerve fiber to brain is caused, there is reduction of patient anxiety, anxiety in practice, it is tight for flesh caused by nerve Opening has certain therapeutic effect.But inevitably there is situation about being interfered with electrocardiosignal during Neural stem cell, Above-mentioned interference can also be improved by the way of electrocardio triggering magnetic stimulation circuit while being shielded, this is also this area skill Art personnel are difficult to technical problem urgently to be resolved hurrily.Meanwhile, how simplicity quickly and non-invasively to stimulation sites is accurately positioned It is then problem that those skilled in the art do not overcome.Conventional physiotherapy practitioner is pressed often through experience and patient feedback enters Row positioning is so both inaccurate to be likely to cause accidental injury；Certainly also it has been proposed that measured by setting up electrode, but Laboratory environment and clinic differ greatly, and testing cost is high very high simultaneously for operator's requirement.

The content of the invention

The present invention provide it is a kind of damaged for patient spine, backbone fatigue and related muscle group it is nervous alleviate, treatment it is whole Complex system.Which overcoming conventional reduction device can only be directed to the shortcoming of single spinal problems, comprehensive various treatment means, default Intelligent therapeutic is realized under the monitoring of detection program.Simultaneously as considering that the same presentation of user is that may be present various pathogenic Mechanism, the detection being combined using various detection means, decision logic are allowed the devices to voluntarily according to the specific feelings of user Condition makes appropriate physiotherapy.So as to realize effective, safe backbone reduction, rehabilitation, it is to avoid unnecessary secondary damage or delay.

The reduction device that the present invention is referred to include checking with EMG method module 1, magnetic therapy module 2, supporting module 3, control module 4, Display module 5 and electrocardio module 6 etc..

The present invention relates to electro physiology and electromagnetism medical domain.Myoelectricity (EMG) signal known to us, its amplitude, frequency spectrum With own characteristic：The surface EMG signal measured from body surface is generally very faint, and amplitude is usually no more than 5mV；Frequency also compares Relatively low, spectral range is generally 0.02-1000Hz, and spectrum energy is concentrated mainly between 0.25~350Hz.Muscle lax and There is good linear relationship between tensity and generation surface myoelectric voltage amplitude.Measurement myoelectricity voltage magnitude uses square Root method, can both reflect the variation characteristic of EMG signal amplitude on time dimension, and depending on muscle load sexual factor and muscle Inner link between physiology, biochemical process itself, therefore, the time-domain analysis index is commonly used in real time, with no damage Reflection muscle activity state, with preferable real-time.Meanwhile, the impedance of human muscle part can effectively state human body and loosen Degree, in general human body get over and loosen, impedance is smaller.Therefore combining can in real time, exactly obtain human body flesh using the above method Meat tensity, and it is classified.

The muscle tonue degree for obtaining may be comprising much information, for example caused bone injury, lactic acid such as backbone strain, hyperplasia Pain caused by metabolism disorder and muscle cramp, and by muscular tone caused by external force or psychology etc..If can not have Effect differentiation causes myotonic different reasons, then can not effectively carry out immunotherapy targeted autoantibody.The present invention is by body surface specific region Set electromyographic signal acquisition device obtain the real-time myoelectricity of human body, impedance signal, while by can real-time live program gate control logic Preset program in circuit realizes identification and classification for above-mentioned electromyographic signal exception inducement, and according to different judged results To carry out the combination of different treatment means.

First, transcranial magnetic stimulation (TMS) first is implemented to user, selectes stimulated zone and be located at Epidural cavity, lured by magnetic field Hair potentiometric detection.Simple magnetic stimulator is by dc source, charging circuit, energy-storage travelling wave tube, discharge switch, charge-discharge control circuit Constituted with several parts such as coil.Various transcranial magnetic stimulation instruments well known to those skilled in the art and including including software control dress Put and the present invention be introduced into by reference, such as DTMS transcranial magnetic stimulations circuit arrangement described in US2008200749A or U.S.'s Medtronic Mag Pro type magnetic stimulators of commercialization.

Using the excitement that Neural stem cell cortical motor area is produced, spinal cord anterior horn cell or surrounding god are made by descending conduction path Depolarized through motor fiber, in the potential change as Motion Evoked Potential detection thorn that respective muscle, nerve, spinal cord recorded Swash.According to different stimulus modalities, SRPs can be divided into sensory evoked potential (somatosensory evoked potential, ) and Motion Evoked Potential (motion evoked potential, MEP) SEP.SEP mainly reflects the up conduction of spinal cord dorsal part Feel the function status of path, and then reflect the integrality of ventral side of spinal cord downward movement conduction path through the MEP that cranium stimulates.By MEP contributes to whether detection backbone has substantive damage, has particularly with the latent lesion for not embodying obvious physical handicaps There is preferable flaw detection effect.MEP can be divided into Spinal motor evoked potentials (SCMEP), nervimotion Evoked ptential (MEP-N) and flesh Meat Motion Evoked Potential (MMEP), can serve as human body different parts neurotrosis detection and is used respectively.Maerten, Dvorak Et al. research point out that in vertebral disease and the protrusion of the intervertebral disc, the sensitiveness of MEP is 84%, and 36% compared with SEP substantially increases Height, and MEP is slightly above lumbar spinal stenosis to the sensitiveness of spinal canal stenosis.Speculate with cervical spinal canal small volume, it is narrow after be more easy to Caused by compressing spinal cord.It is 85% that Machida has then been reported through the sensitiveness of cranium MEP Spinal Cord Injury of Trauma patients.In order to logical Cross skull and scalp etc. and reach stimulation location, it is special to cause that peak magnetic field is not smaller than 1 by the selection of coil turn and current value Si La (T), typically should be between 1-2T.Tangentially relation sets flat board circular coil (its therewith at the top of user's skull Field stimulation is larger, is more suitable for peripheral nerve), its can be ironcore choke or built-up coil, coil diameter 12-20 centimetres it Between, hub of a spool is less than 3.5 centimetres away from user crown distance.Because being only used for physiological detection, therefore action time is short, using certainly So cool down or air cooling way.Via the coil, 1-3 centimetres of depth realizes fast frequency TMS in user's skull, also immediately The time-varying magnetic field frequency that time-dependent current is produced is more than 1Hz.The use of common motor potential detector is to be capable of achieving for being pierced through cranium magnetic Swash the detection of MEP signals, visited for spinal cord conduction path by analyzing the conventional indexs such as its conduction time and signal magnitude Wound.This kind of situation should strictly forbid the mechanical massage for affected part or region of interest, it is to avoid follow-up massage step is produced for vertebra Raw secondary damage.

Secondly, periphery Nervous pathway can also be detected by MEP.The acquisition methods of the MEP of peripheral nerve with Existing SEP technologies are similar to, by setting the anode of paster leading electrode in targeted muscles abdomen to be measured, and in neural descending tendon section Negative electrode is set, it is ensured that distance is on 35mm between electrode.Subcutaneous microneedle electrodes can be used instead if necessary and improve picking up signal effect Fruit and avoid noise jamming.Can be stated according to patient master simultaneously, carrying out MEP signals in specific limbs nerve pathway or neuromere picks up Take, and then targetedly pay close attention to the myoelectricity ripple conducted via specific spinal levels, can exist to specific nerve pathway and damage Wound carries out observational measurement.The selection of the targeted muscles is with the conventional selection standard of this area transcranial magnetic stimulation signal detection Can, in principle to be preferred at the four limbs major muscles away from trunk, it is not limited to wherein.

In the waveform signal that MEP detections are obtained, the quick first single-phase positive phase wave for reaching is referred to as ground wave (D ripples), Because its conduction is transmitted without cynapse, so also referred to as ground wave；And one group of positive wave (I ripples) is occurred in that after D ripples, it is contact Caused by fiber indirect excitation cones, referred to as indirect wave.Electro photoluminescence draws MEP waveforms prompting spinal cord conduction beam function normally, And waveform disappears and shows that retardance, the i.e. decision principle of " all or none " or decreased amplitude 80% occurs in conduction function, its monitoring is sensitive Degree is up to 100%.If there is D ripple blocks, classification will be made by gating circuit, and forbid mechanical massage to carry out, anti-major structure Injured into treatment.And it is normal in the conduction of D ripples, and I ripple incubation periods lengthen (criterion is substantially between 2.5-5 times of ordinary duration) Imply that there is inflammation damnification, such as overwork etc. causes demyelinate symptom.Clinical trial shows in patient without anesthesia waking state Under, double transcranial magnetic stimulation above can be simulated effectively stimulates normal induction signal.Appropriate mechanical massage is aided with magnetic The myoelectricity for inducing stimulates and contributes to enlivening for neuron and conduction path.

Finally, checking with EMG method module also includes the pick device for myoelectricity (such as surface electromyogram signal), is used to detect Neuroelectricity conducting power.Terminate in MEP detections, judge that patient is not suitable for mechanical massage in the absence of spinal cord, neurotrosis etc. After disease, the electromyographic signal of the myoelectricity pick device specific massage part of real-time detection patient.Muscle occur pain, spasm or During simple fatigue problem, problem points (including pain point, spasm point and tired area etc., as follows) peripheral nerve fiber conduction speed Degree slows down, poor blood circulation, and this also complies with general cognition.It can be obtained and be made further by the detection of electromyographic signal Distinguish.

Recent kinematics research shows：Human skeletal muscle's slow switch fibers is more, and area percentage is bigger, the frequency of electromyographic signal MPF descending slopes are slower in domain analysis index.Further, especially chronic long pain can cause local muscle fast to pain Muscle fibre accounting and volume increase and slow switch fibers is accordingly weakened, so as to cause MPF value descending slopes to significantly increase.For example, Clinical discovery teres minor muscle pathological inflammatory or non-pathologic spasm can cause dorsal root ganglia frequency of spontaneous discharges to increase Plus, radial pain as a result may be produced at corresponding side root pain and upper limbs.Problem points --- phase around painful area Closing nerve fiber can have the generation of high frequency electrical signal, be presented as median frequency dramatic decrease, namely median frequency slope (median frequency slope, MPs) raises obvious.Inventor thinks the height occurred during this nerve fibers conduct The quick interruption phenomenon of frequency, is a kind of self adaptation phenomenon of human body under incomplete block.The high frequency intermittent phenomenon of problem points electric signal, So that organ-tissue peripheral cell electric charge quickly changes between reduction increasing.This high frequency flash is both that a kind of physiology refers to Mark, can also exist as one kind stimulation, treatment means.

And in the aching pain of muscles that sports fatigue is produced, it is emerging to maintain muscle tone to strengthen motor unit during due to fatigue The synchronism put forth energy；And the caused blood flow of intramuscular pressure increase is obstructed and the sarolemma surexcitation of generation is piled up with lactic acid, so as to lead MFCV reduction (muscle fiber conduction velocity) is caused, can be with this fatigue after exercise As dominant index.It passes through massage, physiotherapy can realize that myoelectric amplitude is slowly raised, the frequency of average power of electromyographic signal (median power frequency, MPF) is also raised simultaneously, it is understood that for fast muscle fiber is rested, lactic acid metabolism Recover normal with problem points blood circulation.

The electrode sample frequency for detecting pain signal is 300Hz-500Hz, preferably 450Hz；Tired signal detection electrode Setting sample frequency is 8-300Hz, more preferably preferably 20-100Hz, 50Hz.Common-mode rejection ratio is more than 120dB, sensitivity 1 μV., using active surface electrode measurement flesh surface electrical activity, conduction region diameter is between 6-12mm for pickoff electrode.Electrode selects stone Electrode ink or Ti electrode, prevent it from occurring in magnetic field unexpected.

Patient's readme affected part is smeared and to backbone side extension smearing, the Pi Wenbian using skin temperature allochroic paint before placing electrode Color coating can effectively identify body surface temp different, the position of the influence blood circulation such as muscular tone, spasm and around and it is strong Side forms sharp contrast.The skin temperature allochroic paint uses palmityl alcohol, two kinds of binary mixtures of organic matter of myristyl alcohol for molten Agent, by adjustment, both are allowed to color change interval between substantially 30-44 degrees Celsius with when processing technology, further in Between 33-40 degrees Celsius.Mark is made in the above-mentioned low temperature point with significantly lower than strong side and peripheral part.

Every group of three electrodes are set centered on the mark point, active, measuring electrode line parallel to mark point at Main muscle fibre trend, major axis is in the same direction with muscle fibre in itself for electrode, spacing 2-2.5cm, and avoids being positioned on tendon as far as possible, in Property electrode be placed on above-mentioned mark point nearby voltage-neutral location.Strong side is symmetrically chosen, and equally sets one group of electrode.

Electromyographic signal in-situ processing device is connected with after electromyographic signal pick device, it is patrolled after realizing filtering, amplification Collect and judge, if the signal obtained in low-frequency sampling sequential enters tired signal and judges process；If in high frequency sampling time sequence The signal for inside obtaining then judges process into pain signal.In above-mentioned electromyographic signal judgement process, realize that fast Flourier becomes Its MPF value is got in return, to carry out frequency-domain analysis.Whether met using Matalab analyzers monitoring MPF values during frequency-domain analysis , for example there is rapid decrease in pre-set level or even flash (similar cliff of displacement formula declines) phenomenon then indicates it to enter alleviation pattern 2-1, Otherwise enter relaxed mode 2-2；Also can be judged using adaptive neural network mode of learning, Binding experiment number of chambers evidence To natural spine both sides myoelectricity distribution map, human region myoelectricity is set for different heights, age, body weight or even Anthropometric parameters and is added Weight coefficient table, judges after Ipsilateral myoelectricity data/strong side data exceedes weight coefficient.

The working procedure of control module is carried out according to lower row logic during above-mentioned picking up signal：Detection transcranial magnetic stimulation Targeted muscles produce MEP signals, judge neural descending conductive link with the presence or absence of damage, be embodied in D ripples whether by It is correctly detecting；Then strictly forbid any type of mechanical massage if there is link conductive impairment；If MEP signals are normal Into real-time table facial muscle pyroelectric monitor process, mainly whether there is rapid decrease or even sudden strain of a muscle by MPF values in monitoring signals among these Disconnected phenomenon come determine enter which kind of massage mode, also can further combined with MPs signals and monitoring electromyographic signal latent time.

In pattern 2-1 is alleviated, apply magnetostatic field, size 0.6-0.9T is arranged on massage bed (or left and right) direction up and down； Backbone side being traced back in skin temperature indicating positions and applying ultrasound, the ultrasound converges depth 0.8-2.5cm, frequency 0.2-1.0MHz, work( Rate 1mW/cm²；Ultrasonic transducer used is close to skin, and transducer probe effective area 10mm × 8mm is longitudinally perpendicular in human body ridge Post direction.Ultrasound corresponds to the convergent point that 1 sq is formed at substantially neuromere, nerve fiber at this in hypodermis Middle cell membrane can be vibrated with intracytoplasmic charged particle, and cell membrane depolarization is caused according to Hall effect.Action electricity Position will be conducted to corresponding skeletal muscle, cause slightly to twitch or tremble.This action potential is sent by autologous patient neurode, tool There are altitude simulation and adaptability, induction obtains its size of action potential and supersonic frequency nonlinear correlation.At the same time, it is foregoing Supersonic frequency size makes adaptive change with the electromyographic signal that foregoing pickoff electrode is obtained, and the feedback system causes myoelectricity MPF drop-out values reduce.Because " logical or nothing " characteristic of multiple neuron membrane depolarizations, clinically it is observed that above-mentioned induction The non-linear increase of current potential, namely its be likely to occur do not follow supersonic frequency regulation and the phenomenon of linear change.Control module pair The regulation of supersonic frequency is carried out in units of 0.1KHz, and the supersonic frequency of regulation keeps at least one more than the cycle, in week every time Period is every the above-mentioned MPF values of detection.

In relaxed mode 2-2, apply magnetostatic field (avoiding acting on user's head), size is 2.5T, can be in massage (or left and right) direction is set bed up and down；Then selection temperature change most visibility point is indicated as gradient magnetic according to above-mentioned skin temperature Field action band center, applies gradient magnetic, and its size is 100mT, switching rate 10-15mT/m.s (y circles).Under its effect, on State zone of action imperceptible random so as to naked eyes occur including the tissue generation bioelectrical effect including nerve, MRO Then belly of muscle shake, it contributes to blood circulation and lactic acid metabolism, while being produced more or less according to gradient magnetic switching rate is different Heat.The heat of generation will cause to be coated with the part occurrence temperature change of skin temperature allochroic paint, reach the phase that wherein includes Phase-change material will be caused to absorb heat liquefaction after becoming material threshold, so as to avoid skin fire damage.Meanwhile, operator can pass through The color monitoring skin temperature of skin temperature allochroic paint.In the dwelling period of gradient magnetic, myoelectricity acquisition module is started working the cycle When, above-mentioned phase-change material will also have an effect to avoid coated portion temperature too low, prevent skin, muscle due to cold and hot change Muscle tonue causes electromyographic signal error caused by changing.

Electrocardiogram large sample analysis result for different parting cervical spondylosis patients shows cervical spondylopathy and electrocardiographic abnormality With larger correlation or even homogeneity, therefore the neck heart syndrome that is otherwise known as.The process of magnetic stimulation is being carried out to peripheral nerve The biological electricity of middle generation inevitably will partly overlap or even conflict with electrocardiosignal.Clinical data shows such case Particularly evident in Patients with Cervical Spondylopathy, the error burst of ultrasonic magnetic field therapeutic effect will be significantly increased.If can be further Ground increases heart real time detection in the above-mentioned magnetic therapy module course of work, it will refer to for the incision of ultrasonic magnetic therapy provides more preferable opportunity Show.

Huo Dun (Holden) showed that vascular wall can produce an electrical potential difference in magnetostatic field in body surface in the research of 2004, The induction field may influence propagation (the The sensitivity of the heart to static of electrocardio action potential magnetic fields【J】.Progress in Biophysics＆Molecular Biology, 2005,87 (2-3)：289_ 320.).For the ECG detecting results such as three existing frequently-used leads, five leads, 12 lead, magnetostatic field induced electricity The influence of gesture is mainly reflected in the deformation of T ripples or time delay.Magnetostatic field is treated in alleviation pattern 2-1 for example of the present invention, because magnetic field Intensity is smaller to be not enough to significantly affect electrocardio generation, but is contrasted still it can be seen that similar by detection and experimental result Interference of the bad electrical potential difference for therapeutic effect.In order to avoid interference can for electrocardiogram equipment set up reliable ground, wave filter and Metal housing etc..Further, the ultrasound in by circuit electrocardiosignal being caused to realize S ripples triggering pattern 2-1.

And during the field variation of relaxed mode 2-2, the detection of electrocardiosignal tends to occur serious distortion, so such as What realizes the technical problem that more preferable magnetic therapy incision opportunity would be further desirable to solve.Carried out in Hebei Normal University《Abdomen Formula is breathed for Heart rate influences》The rhythm of the subjective control abdominal respiration of as shown by data obtained in experiment helps to control heart rate In a relatively low and stable level.The correlative study of same Xi'an Communications University also indicates that heart rate and breathing can be accomplished Interact, its coupled relation will not be described here.In the present invention, relatively low heart rate is bioelectric to peripheral nerve dry for avoiding It is substantially favourable to disturb；Simultaneously can there is an obvious loosening stage, the rank in the EEP respiratory muscle in abdominal respiration Section can reach 6-8 seconds by using the conscious extension of person.The gradient magnetic switching rate in 2-2 massaging ways is now controlled to be Peak value, will obtain more preferable effect.Therefore the present invention further sets breathing instruction device, it uses the acousto-optic of any prior art Electricity etc. points out means, and such as buzzer or LED flash are adornd.For indicating user to carry out the frequency of abdominal respiration, together When user enter steady breathing state after coordinate gradient magnetic change, make the expiration of magnetic field switching frequency and abdominal respiration Stage keeps synchronous.Clinical trial shows that most of adults can keep when coordinating breathing instruction device to carry out abdominal respiration Respiratory rate per minute 5-7 times, while heart rate will drop to the relatively low heart rate level in its normal range (NR).Now combined magnetic field is controlled Therapeutic effect is significantly increased, and in the case for the treatment of time is isometric, the MPF values for measuring relative can rise 1%-10%.

Again further, medicine adjuvant treatment effect is increased in above-mentioned reduction system work process, it is by medication mould Block is realized, it is therefore intended that promote local location blood flow, improves the remission effect of muscular tone.The medicine uses this area Psoralen, promoting blood circulation proved recipe increase and decrease, are mixed into foregoing after active ingredient is further ground after boiling purification known to technical staff The position for receiving magnetic therapy is coated in skin temperature allochroic paint.Skin is penetrated into after the process said medicine of Neural stem cell is heated to realize Drug effect.

Specific embodiment

Backbone reduction system includes that, used as the physiotherapy stand 31 for carrying user, the stand is provided with corresponding to people's Head And Face It is easy to user's prostrate to breathe in opening.Stand uses non-metallic material, it is to avoid influence electromagnetic curing therapeutic effect, and lower section is provided with four The support post of band roller.Ring-type fence 32 is provided with around the stand 31, fence has activity in correspondence user foot Railing, overall fence is in the retractable shape of the mouth as one speaks in one end.Support arm 321 is provided with the corresponding user's head position of fence 32, is being enclosed Column side correspondence user's trunk is provided with the support arm 322 of more than many.The support arm can be with multi-angle rotary, bending simultaneously And can slide to adapt to diverse location on fence.Support arm material uses nonmetallic, and its end is provided with fixed seat 323. Ultrasonic probe, infrared probe, gradient magnetic field coil etc. are detachably connected with the fixed seat of above-mentioned support arm.It is left in fence Side is provided with magnetostatic field generator 324, provides magnetostatic field referring now to user's metastomium on stand 31 in fact.Size is specially 0.6-0.9T, is realized by steady controllable current, can use the various common techniques in this area.In enclosing for correspondence user's head position Magnetic shield panel 325 is provided with column, it uses magnetic conductivity ferromagnetic material high, and such as silicon steel is made can be along the screen of fence slidable adjustment Shield plate, thickness is between 1-5mm.Foldable lid is overlying on user's head to be prevented effectively from user's head after sliding into appropriate location Portion receives unnecessary magnetic stimulation.

Flat board circle or splayed coil 21 are removably fixed with the fixed seat of above-mentioned support arm 321, it can be iron Wire-core coil or built-up coil.Between 9-20cm, preferably 12-15cm, the peak magnetic field of generation is not less than 1T to coil diameter.In warp By adjusting support arm so that hub of a spool is less than 3.5cm away from user crown distance during cranium Neural stem cell.Changing currents with time is produced Raw field frequency is more than 1Hz, and the winding wire is connected to control device by the fixed seat on support arm 321. The transcranial magnetic stimulation stage sets anode electrode 11 at user back or upper limbs targeted muscles belly of muscle, at neural descending tendon Cathode electrode 12 is set.Electrode uses graphite electrode, between the two away from more than 35mm.The signal that above-mentioned two electrode is collected is sent to Control device, filtered shaping is analyzed after amplifying：Controlled in the case of retardance occur in the first single-phase positive D ripples for receiving Device carries out alarm, reminds operator that the user can not carry out any type of mechanical massage and stop further warp Cranium Neural stem cell is carried out；It is normal in D ripples, and there is time delay more than in the case of 2.5 times of ordinary duration in one group of follow-up positive I ripple, passes through Cranium Neural stem cell is normally carried out a cycle or detects that I ripple incubation periods stop after shortening.A cycle can be recognized by control device It is input, typically between 120s-600s.

The selection of above-mentioned targeted muscles can be according to user's readme, it is also possible to after being observed using skin temperature allochroic paint Carry out.Specific practice is：It is raw material to choose palmityl alcohol, myristyl alcohol, procrypsis agent and developer, and wherein procrypsis agent can choose temperature-sensitive Dye crystallization violet lactone CVL, developer chooses diphenol propane BPA, and two kinds of alcohol exist as solvent and proportioning thing.By solvent and Solute is poured into the container of heating water bath to stir enough one hour and obtains compound.Its discoloration depends on four kinds of matter of material Amount ratio, as CVL: BPA: myristyl alcohol: the mass ratio of palmityl alcohol is at 1: 3.3: 41: 22, compound fusing point is minimum, and There is good discoloration between 33-40 degrees Celsius.Above-mentioned compound is uniformly mixed with common phase-change material, phase-change material Paraffin etc. can be chosen, causes its phase transition temperature at 40 degree or so by simple proportioning processing.Mixed phase-change material and upper State compound and coat user's readme affected part and strong side correspondence position.Observation whether there is obvious skin temperature discoloration after parked 3 minutes Phenomenon, is marked with surrounding skin significant difference or with the visibly different position in strong side.

Surface electromyogram signal pickoff electrode is set centered on mark point, and one group of three wherein neutral electrode of electrode 13 is put Put in the voltage-neutral location nearest away from mark point, active measuring electrode then ensure its line it is parallel with mark point at main muscle fibre Trend, major axis is in the same direction with muscle fibre in itself for electrode, and two electrodes should now avoid being positioned on tendon at a distance of 2-2.5cm.Strong The same symmetrically placed one group of electrode 14 in side.The electrode sample frequency for detecting pain signal is 300Hz-500Hz, preferably 450Hz； It is 8-300Hz, more preferably preferably 20-100Hz, 50Hz that tired signal detection electrode sets sample frequency.Common-mode rejection ratio More than 120dB, the μ V of sensitivity 1., using active surface electrode measurement flesh surface electrical activity, conduction region diameter is in 6- for pickoff electrode Between 12mm.Electrode selects graphite electrode or Ti electrode.

The wire drawn from two arrays of electrodes obtains its MPF value by realizing FFT after filter and amplification respectively. Thereafter two groups of data respectively enter the logic judgment unit 41 of control device.The Ipsilateral signal obtained in high frequency sampling time sequence enters Enter pain signal and judge process, and the Ipsilateral signal obtained in low-frequency sampling sequential judges process into low frequency.In each judgement The Matalab analyzers 42 of control device carry out frequency-domain analysis to it in process, first determine whether what is obtained in high frequency sampling time sequence MPF values whether there is there is rapid decrease or flash phenomenon, and for measurement, the corresponding median frequency slope (MPs) whether there is substantially criterion Raise, its slope value normal range (NR) should make default with reference to user's age, body fat, body weight and strong side to induction signal, also may be used Adaptive learning acquisition is carried out by user's many experiments.The general MPs values are more than or equal to 60% i.e. it is believed that user Affected part muscle need to carry out physiotherapy alleviation, into process 2-1.If the MPF values obtained in high frequency sampling time sequence are without appearance The situation of above-mentioned rapid decrease, the MPF values that further analysis affected part low-frequency sampling is obtained of analyzer 42, and also according to above-mentioned step Rapid being analyzed is compared.Now MPs values are more than 45% and be may determine that with reference to the latent time of electromyographic signal for collecting and use Person needs to carry out physiotherapy to loosen, into process 2-2.

In pattern 2-1, control device starts magnetostatic field generator 324 and applies magnetostatic field, and size 0.6-0.9T's is magnetostatic Field puts on user's trunk, especially at backbone；Setting region of insonation at the 5-10cm of backbone side is traced back in mark point；It is logical Cross ultrasonic probe and apply ultrasound, the ultrasound converges depth 0.8-2.5cm, frequency 0.3-1.0MHz, power 1mW/cm²；It is used The transducer of ultrasonic probe is close to skin, and transducer effective area 10mm × 8mm is longitudinally perpendicular in human spine direction.Ultrasound Correspond to the convergent point that 1 sq is formed substantially at neuromere in hypodermis, at this in nerve fiber cell membrane with Intracytoplasmic charged particle can be vibrated, and cell membrane depolarization is caused according to Hall effect.Action potential will conduct To corresponding skeletal muscle, cause slightly to twitch or tremble.At the same time, it is foregoing.Supersonic frequency size is obtained with foregoing pickoff electrode Electromyographic signal make adaptive change, the feedback system cause myoelectricity MPF drop-out values reduce or in other words cause MPs values " rising ".The a cycle that often works control device stops magnetic field function, into surface electromyogram signal acquisition sequential.Mode of operation 2- Enter high frequency sampling time sequence after 1, the skin surface electromyographic signal of pickup repeats the above steps again.Until the MPF that measures or MPs values reach preset standard.

In pattern 2-2, apply magnetostatic field (avoiding acting on user's head), size is 2.5T, can be left in massage bed Right direction is set；Then selection temperature change most visibility point is indicated as in Actions of Gradient Magnetic Field band according to above-mentioned skin temperature The heart, applies gradient fields, and its size is 100mT, switching rate 10-15mT/m.s (y circles).Gradient coil be arranged on foregoing support arm it On one.

Under the Actions of Gradient Magnetic Field, there is biological electricity in above-mentioned zone of action including the tissue including nerve, MRO Effect in the imperceptible random form of naked eyes so that realize that belly of muscle is shaken.Clinical trial show this stimulating circulation and The fatigue recovery of corresponding nerve pathway is additionally aided after lactic acid metabolism, while being produced or many according to gradient magnetic switching rate is different Or few heat.The heat of generation will cause the part occurrence temperature for being coated with skin temperature allochroic paint to change, and wherein be included reaching Phase-change material threshold value after will cause phase-change material absorb heat liquefy, so as to avoid skin fire damage.Meanwhile, operator can be with Skin temperature is monitored by the color of skin temperature allochroic paint.In the dwelling period of gradient magnetic, myoelectricity acquisition module is started working During the cycle, above-mentioned phase-change material will also undergo phase transition release heat to avoid coated portion temperature too low, prevent skin, flesh Meat due to caused by cold and hot change muscle tonue cause electromyographic signal error.Gradient magnetic switching rate size is obtained with foregoing pickoff electrode To electromyographic signal make adaptive change, the feedback system cause myoelectricity MPF drop-out values reduce or in other words cause MPs values " rising ".The a cycle that often works control device stops magnetic field function, into surface electromyogram signal acquisition sequential.The difference is that work Enter low-frequency sampling sequential after operation mode 2-2, the signal of pickup repeats the above steps again, until MPF or MPs values reach it is pre- Bidding is accurate.

Wherein described gradient magnetic field coil sets figure-eight coil by foregoing support arm holders, the coil upper half Individual 0 is fixed in fixed seat, is arranged on foregoing stand lower section for half 0 down.Upper lower coil is relative to be constituted, and whole coil can be followed The movable change to adapt to diverse location of support arm.

Infrared skin temperature monitoring probe can be further set up to prevent scald.The infrared radiation thermometer is used This area common technique is to be capable of achieving, and its monitoring range is between 30-45 degrees Celsius.Its detecting head is solid installed in foregoing support arm In reservation, electrically connected with control device.By the way that in the default early warning temperature of control device, such as 41 degrees Celsius (need to consider herein The specific selection of phase-change material) temperature pre-warning for monitor area is realized, prevent from scalding or unexpected occur.

It is further in order to avoid in pattern 2-1 magnetostatic field produce electric potential field mutual with electrocardio action potential in vascular wall Influence, can be using introducing electrocardioscanner 61.It uses the modes such as three common leads, five leads or 12 lead to detect makes User's electrocardio.Electrocardioscanner 61 is entered using modes such as reliable ground, wave filter and outer cover metal-coatings in order to avoid disturbing Row protection.The startup of electrocardio S ripples triggering ultrasound can also be realized using detection triggers circuit.Namely increase on electrocardioscanner If related circuit：ECG signal sampling circuit 62 realizes the amplification to electrocardiosignal, and, in 1-2KHz, multiplication factor can for signal band To adjust；S ripples detecting circuit 63 is made up of follower, QRS wave filters, whole wave circuit, peak-holding circuit and comparator.Electrocardio Figure output signal to be converted to be input to after the whole ripple of voltage signal and detect S ripples in monostable flipflop, and obtains S ripple lock-out pulses Signal.Drive circuit is triggered in the rising edge of S ripples, the startup for ultrasonic signal is realized.Evaded out based on the triggers circuit The R ripples effect of heart action potential, so as to reduce both influence each other.Further, triggers circuit not directly with startup Circuit is connected and passes through control module and be connected with start-up circuit.Now after rising edge trigger signal is obtained, control module should Signal is kept in, and ultrasonic signal is just started after next trigger signal is obtained；Above-mentioned temporary behavior can effectively reduce periphery god The refractory period reaction of warp, increases treatment effective time.Temporary two or more triggerings also can further be set according to actual effect Driving ultrasound circuitry of just being awaited a favorable opportunity after signal works.

Further in order to realize more preferable magnetic therapy incision opportunity problem in pattern 2-2.In fence near user Head position sets up a buzzer or similar warning means.The buzzer electrically connects control device and by its management, for instructing User carries out the frequency of abdominal respiration, while coordinating the change of gradient magnetic after user enters steady breathing state, makes Magnetic field switching frequency is synchronous with the expiration phase holding of abdominal respiration.Specifically buzzer sounds and points out user's air-breathing, control Device processed controlled between buzzer sounds 3s-6s the switching rate of gradient magnetic field coil be at least held in its peak value 80% it On.Clinical trial shows that most of adults can keep per minute 5-7 times when coordinating breathing instruction device to carry out abdominal respiration Respiratory rate, while heart rate will drop to the relatively low heart rate level in its normal range (NR).Now combined magnetic field therapeutic effect has aobvious Write and improve, in the case for the treatment of time is isometric, the MPF values for measuring relative can rise 1%-10%.

Again further, medicine adjuvant treatment effect is increased in above-mentioned reduction system work process, it is by medication mould Block is realized, it is therefore intended that promote local location blood flow, improves the remission effect of muscular tone.The medicine uses this area Psoralen, promoting blood circulation proved recipe increase and decrease, are mixed into foregoing after active ingredient is further ground after boiling purification known to technical staff The position for receiving magnetic therapy is coated in skin temperature allochroic paint.Skin is penetrated into after the process said medicine of Neural stem cell is heated to realize Drug effect.Specific drug component is following (mass ratio)：Barrenwort 5, the rhizome of davallia 21, the root of bidentate achyranthes 6, safflower 1, windproof 9, Moschus 1, mountain paint 2, Dragon's blood 11, Psoralea corylifolia 3, amber 4, Ligusticum wallichii 10, notopterygium root 2.The drug ingedient also can individually be coated with after skin temperature allochroic paint is removed In affected part, now temperature monitoring is completed by foregoing infrared probe completely.Also aerogel dressing cooperation can be set up during use； Even spread said medicine coating in medical aseptic transparent aquagel dressing layer；Dressing layer is cut out for given shape, ridge is laid in The main muscle group in post both sides, such as erector spinae, multifidus etc., are not limited to specific magnetic therapy position；Need to coordinate corresponding coat simultaneously after The mechanical stretch effect of muscle group, it is realized by setting up upper limbs mechanical stretch bar；The stayed pole is located at massage platform user Head side, height is slightly above the user back of prostrate；, parallel to the platform, force direction is away from human body for direction of draw So as to realize the drawing to user's upper limbs；By control module control, frequency is between per minute 5-15 times for drawing.Further , drawing can be engaged with abdominal respiration frequency.Specifically, buzzer sounds after prompting user breathes and is pulled, and leads Pull and support it is continuous 4-8 seconds after loosen；User is disappeared using traction force and is indicated as exhaling.

Foregoing control device can be gated circuit or microcomputer etc. and be realized using the common single-chip microcomputer in this area, field-programmable, With the use of keypad or conventional keypad as input unit.

Above-described embodiment is illustrated as just technical solution of the present invention and is used, and should not understand its protection model as restriction Enclose.Those skilled in the art on the basis of the present invention done any improvement for not departing from present inventive concept or remodeling without departure from this Invention protection domain.

Claims (2)

1. a kind of medication coat for being applied to backbone reduction system is constituted, and the backbone reduction system includes：

Checking with EMG method module 1, magnetic field module 2, massage module 3, control module 4, display module 5 and electrocardio module 6 etc.；Wherein The checking with EMG method module real-time detection human body surface myoelectric, and classified according to myoelectricity level and feature, the classification knot Fruit can be tight to muscle caused by muscle tonue caused by user's bone injury, lactic acid metabolism imbalance and spasm and external force or psychology Etc. make a distinction；The classification results that the control module is sent according to checking with EMG method module enter default alleviation massage mode 2- 1 or relaxing massage pattern 2-2；

It is characterized in that：Increase medicine adjuvant treatment effect in above-mentioned reduction system work process；The specific medicine of medicine The following mass ratio of component：Barrenwort 5, the rhizome of davallia 21, the root of bidentate achyranthes 6, safflower 1, windproof 9, Moschus 1, mountain paint 2, dragon's blood 11, Psoralea corylifolia 3, Amber 4, Ligusticum wallichii 10, notopterygium root 2；Further ground in mortar grinder by inserting active ingredient after boiling, filtering purification, it Skin temperature allochroic paint is mixed into afterwards coats the position for receiving magnetic therapy；Skin is penetrated into after the process said medicine of Neural stem cell is heated Realize drug effect；The drug ingedient also individually can coat affected part after skin temperature allochroic paint is removed, now temperature monitoring it is complete by Additional infrared probe is completed.

2. medication coat is constituted according to claim 1, and aerogel dressing cooperation is set up during use；It is saturating in medical aseptic Even spread said medicine coating in hydrous gel dressing layer；Dressing layer is cut out for given shape, backbone both sides is laid in main Muscle group, such as erector spinae, multifidus etc., are not limited to specific magnetic therapy position；Need to coordinate the machinery of corresponding muscle group coat simultaneously after Drawing effect, it is realized by setting up upper limbs mechanical stretch bar；The stayed pole is high located at massage platform user's head side Degree is slightly above the user back of prostrate；Direction of draw is parallel to the platform, and force direction is right so as to realize away from human body The drawing of user's upper limbs；By control module control, between per minute 5-15 time, further pulling can also coordinate frequency drawing The frequency of user's abdominal respiration is carried out.