CN106890203A - A kind of gumbo extract and its preparation method and application - Google Patents
A kind of gumbo extract and its preparation method and application Download PDFInfo
- Publication number
- CN106890203A CN106890203A CN201710262881.8A CN201710262881A CN106890203A CN 106890203 A CN106890203 A CN 106890203A CN 201710262881 A CN201710262881 A CN 201710262881A CN 106890203 A CN106890203 A CN 106890203A
- Authority
- CN
- China
- Prior art keywords
- gumbo
- extract
- preparation
- supernatant
- gumbo extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of preparation method of gumbo extract, comprise the following steps:Dry gumbo is crushed to 90 100 mesh, gumbo dry powder is obtained;Gumbo dry powder is taken, petroleum ether is added, it is well mixed using high-speed homogenization machine, filtered after degreasing, obtain filtrate;Boiling water is added in filtrate, solid-liquid ratio is 1:9 14, it is well mixed, 4.5 5.5h are extracted under boiling water state, it is centrifuged, collect supernatant;45 times of absolute ethyl alcohols of volume are added in supernatant carries out alcohol analysis, after standing 7 9h, centrifuging and taking precipitation;Precipitation is dissolved in water, the aqueous solution is heated, it is boiling for 10 15min, after after aqueous solution cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo extract.The application of the gumbo extract and extract that are prepared invention additionally discloses a kind of above method.Gumbo extract prepared by the present invention can be used to treat hyperglycaemia.
Description
Technical field
The present invention relates to biomedicine technical field, more particularly to a kind of gumbo extract and preparation method thereof and should
With.
Background technology
Gumbo is Malvaceae Abelmoschus annual herb plant, also known as swordweed, purling eggplant, okra, Abelmoschus esculentus are rich in
Protein, unrighted acid, vitamin, polysaccharide, flavone compound etc., belong to low fat, vegetable low in calories, without cholesterol
Dish.It is demonstrated experimentally that the material in gumbo may participate in the various activities of cell, not only with many bioactivity, and tool
Play the role of to reduce blood sugar.
Glucose in blood is referred to as blood sugar, and blood sugar must keep certain level could to maintain internal each organ and tissue
The need for, when blood sugar concentration exceedes normal value, referred to as hyperglycaemia.Long-term hyperglycaemia can make whole body each histoorgan generation
Lesion, causes the generation of acute and chronic complication.The treatment of current hyperglycaemia, usually drug therapy, but drug therapy can be present
The situation of pharmacological dependence.
How a kind of pure natural substance that can fundamentally reduce blood sugar is provided, is that hypoglycemic therapy field is urgently to be resolved hurrily
One of problem.
The content of the invention
It is an object of the invention to solve above-mentioned at least one problem, there is provided a kind of gumbo extract and preparation method thereof and
Using.
In order to solve the above technical problems, the present invention provides a kind of preparation method of gumbo extract, comprise the following steps:Will
Dry gumbo is crushed to 90-100 mesh, obtains gumbo dry powder;Gumbo dry powder is taken, petroleum ether is added, it is mixed using high-speed homogenization machine
Close uniform, filtered after degreasing, obtain filtrate;Boiling water is added in filtrate, solid-liquid ratio is 1:9-14, is well mixed, boiling water
4.5-5.5h is extracted under state, is centrifuged, collect supernatant;The 4-5 times of absolute ethyl alcohol of volume is added in supernatant carries out alcohol analysis,
After standing 7-9h, centrifuging and taking precipitation;Precipitation is dissolved in water, the aqueous solution is heated, it is boiling for 10-
15min, after after aqueous solution cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo extract.
Wherein, gumbo dry powder is 94 mesh.
Wherein, the degreasing number of times of petroleum ether is 2 times or more than 2 times.
Wherein, filtrate and the solid-liquid ratio of boiling water are 1:10, extraction time is 5h.
Wherein, gumbo extract is fully dissolved using physiological saline, gel filtration chromatography is then carried out, using physiology
Salt solution is eluted, and the elution amount of physiological saline is 2-3BV, collects eluent, and 4-5 times of volume of addition is anhydrous in eluent
Ethanol carries out alcohol analysis, and after standing 7-9h, centrifuging and taking precipitation obtains the gumbo extract of purifying.
Wherein, solid-liquid ratio is g:ml.
In order to solve the above technical problems, the present invention provides the gumbo extract that a kind of above-mentioned preparation method is prepared.
In order to solve the above technical problems, the present invention provide a kind of gumbo extract as hypoglycemic drug or health products should
With.Specifically, gumbo extract is tablet, capsule, granule or powder as the formulation of hypoglycemic drug or health products.
The beneficial effects of the invention are as follows:It is different from the situation of prior art, the preparation method of gumbo extract of the invention
Comprise the following steps:Dry gumbo is crushed to 90-100 mesh, gumbo dry powder is obtained;Gumbo dry powder is taken, petroleum ether, profit is added
It is well mixed with high-speed homogenization machine, filtered after degreasing, obtain filtrate;Boiling water is added in filtrate, solid-liquid ratio is 1:9-14,
It is well mixed, 4.5-5.5h is extracted under boiling water state, it is centrifuged, collect supernatant;4-5 times of volume of addition is anhydrous in supernatant
Ethanol carries out alcohol analysis, after standing 7-9h, centrifuging and taking precipitation;Precipitation is dissolved in water, the aqueous solution is heated, it is seethed with excitement
And continue 10-15min, after after aqueous solution cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo
Extract.Gumbo extract prepared by the above method can be used to treat hyperglycaemia, and gumbo extract is pure natural substance, is being controlled
During treatment, blood sugar is fundamentally reduced, the side effect without pharmacological dependence.
Specific embodiment
Embodiment 1
The preparation method of gumbo extract is comprised the following steps:Dry gumbo is crushed to 94 mesh, gumbo dry powder is obtained, its
In, the gumbo of crushing is Fruit pod part;Gumbo dry powder is taken, petroleum ether is added, degreasing after mistake well mixed using high-speed homogenization machine
Filter, obtains filtrate, wherein, petroleum ether is 4 times of volumes of gumbo dry powder;Boiling water is added in filtrate, solid-liquid ratio is 1:10,
It is well mixed, 5h is extracted under boiling water state, it is centrifuged, collect supernatant;The absolute ethyl alcohol of 4.5 times of volumes is added to enter in supernatant
Row alcohol is analysed, after standing 8h, centrifuging and taking precipitation;Precipitation is dissolved in water, the aqueous solution is heated, be boiling for it
12min, after after aqueous solution cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo extract.
In the present embodiment, the degreasing number of times of petroleum ether is 2 times, and boiling water is distilled water with water, and solid-liquid ratio is g:ml.
The gumbo extract of the present embodiment can be used to treat hyperglycaemia, and without pharmacological dependence side effect.
Embodiment 2
The preparation method of gumbo extract is comprised the following steps:Dry gumbo is crushed to 98 mesh, gumbo dry powder is obtained, its
In, the gumbo of crushing is Fruit pod part;Gumbo dry powder is taken, petroleum ether is added, degreasing after mistake well mixed using high-speed homogenization machine
Filter, obtains filtrate, wherein, petroleum ether is 4 times of volumes of gumbo dry powder;Boiling water is added in filtrate, solid-liquid ratio is 1:12,
It is well mixed, 5h is extracted under boiling water state, it is centrifuged, collect supernatant;5 times of absolute ethyl alcohols of volume are added in supernatant to be carried out
Alcohol is analysed, after standing 8h, centrifuging and taking precipitation;Precipitation is dissolved in water, the aqueous solution is heated, be boiling for it
12min, after after aqueous solution cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo extract.
In the present embodiment, the degreasing number of times of petroleum ether is 2 times, and boiling water is distilled water with water, and solid-liquid ratio is g:ml.
The gumbo extract of the present embodiment can be used to treat hyperglycaemia, and without pharmacological dependence side effect.
Embodiment 3
On the basis of embodiment 1, the gumbo extract for obtaining fully is dissolved using physiological saline, then carried out
Sephadex G-200 gel filtration chromatographies, are eluted using physiological saline, and the elution amount of physiological saline is 3BV, collects wash-out
Liquid, adds 4.5 times of absolute ethyl alcohols of volume to carry out alcohol analysis in eluent, and after standing 8h, centrifuging and taking precipitation obtains the autumn of purifying
Certain herbaceous plants with big flowers extract.
Embodiment 4
On the basis of embodiment 2, the gumbo extract for obtaining fully is dissolved using physiological saline, then carried out
Sephadex G-200 gel filtration chromatographies, are eluted using physiological saline, and the elution amount of physiological saline is 3BV, collects wash-out
Liquid, adds 4.5 times of absolute ethyl alcohols of volume to carry out alcohol analysis in eluent, and after standing 8h, centrifuging and taking precipitation obtains the autumn of purifying
Certain herbaceous plants with big flowers extract.
Embodiment 5
The preparation of gumbo extract tablet:Gumbo extract single-punch tablet press prepared by embodiment 1 or embodiment 2 breaks into directly
Footpath is 7mm, and weight is the piece of 350mg, obtains final product gumbo extract tablet.
Embodiment 6
The preparation of gumbo extract capsule agent:Gumbo extract prepared by embodiment 1 or embodiment 2 is packed into No. 1 with 350mg
Capsulae enterosolubilis, obtains final product gumbo extract capsule agent.
Embodiment 7
The preparation of gumbo extract particles agent:Gumbo extract prepared by embodiment 1 or embodiment 2 is added water and is made softwood, mistake
15 mesh sieves are granulated, and gumbo extract particles agent is obtained final product after drying.
Embodiment 8
The preparation of gumbo extract powder:Gumbo extract prepared by embodiment 1 or embodiment 2 is crossed into 250 mesh sieves, gumbo is obtained final product
Extract powder.
Clinical data one:Choose hyperglycemic patients 180, gumbo prepared by daily 2 embodiments for oral administration 1 or embodiment 2
Extract, continuously takes 3 months.After treatment end, glucose, the level of fructosamine in detection blood samples of patients.Disable gumbo
After extract 1 month, the blood glucose value of patient is detected.
Testing result:After treatment end, 180 patient glucoses averagely decline 15.0%, and fructosamine averagely declines 30.2%.
Gumbo extract is disabled after 1 month, each patient is in the case of healthy diet, and blood glucose value is unchanged.
According to testing result, illustrate that gumbo extract prepared by embodiment 1 and embodiment 2 has the effect for treating hyperglycaemia
With, and over the course for the treatment of, without drugs dependence phenomenon.
Clinical data two:STZ-DM rat models 20 are chosen, diabetes rat is randomly divided into 2 groups, every group 10,0
At the moment, using Instrument for Measuring Blood Sugar and supporting test paper, cut tail and take hematometry basal plasma glucose value, then first group as a control group, fill
Stomach gives blank auxiliary(Cornstarch)Aqueous suspension, second group as experimental group, gavage gives embodiment 1 or embodiment 2
The gumbo extract and auxiliary material of preparation(Cornstarch)Aqueous suspension, blood sugar is measured after giving at regular intervals.Measurement side
Method is specially:Basal plasma glucose with every rat is 100, is calculated during away from 0 moment 50min, 100min, 150min, each rat
Blood glucose value.
Measurement result:During 50min, the average of each rat blood glucose value of control group is 95, each rat blood glucose value of experimental group it is equal
Be worth is 85;During 100min, the average of each rat blood glucose value of control group is 95, and the average of each rat blood glucose value of experimental group is 70;
During 150min, the average of each rat blood glucose value of control group is 93, and the average of each rat blood glucose value of experimental group is 65.Tied according to measurement
Really, it can be seen that gumbo extract prepared by embodiment 1 or embodiment 2 has the work for reducing blood glucose in diabetic rats well
With.
Clinical data three:Hyperglycemic patients 100 are chosen, is divided into two groups, each 50 people, first group of daily 2 times implementation for oral administration
Gumbo extract prepared by example 1 or embodiment 2, second group of gumbo polysaccharide of daily 2 times purifying for oral administration, each group continuously takes 3
Month.After treatment end, glucose, the level of fructosamine in detection blood samples of patients.
Testing result:After treatment end, first group of patient glucose averagely declines 15.1%, and fructosamine averagely declines
30.0%;After treatment end, second group of patient glucose averagely declines 7.5%, and fructosamine averagely declines 14.5%.
According to testing result, illustrate that gumbo extract prepared by embodiment 1 or embodiment 2 has compared with the gumbo polysaccharide of purifying
More preferable effect of reducing blood sugar is used.
Clinical data four:Hyperglycemic patients 100 are chosen, is divided into two groups, each 50 people, first group of daily 2 times implementation for oral administration
Gumbo prepared by gumbo extract prepared by example 1 or embodiment 2, second group of daily 2 embodiment for oral administration 3 or embodiment 4 is extracted
Thing, each group is continuously taken 3 months.After treatment end, glucose, the level of fructosamine in detection blood samples of patients.
Testing result:After treatment end, first group of patient glucose averagely declines 15.0%, and fructosamine averagely declines
30.0%;After treatment end, second group of patient glucose averagely declines 16.2%, and fructosamine averagely declines 32.1%.
According to testing result, illustrate that gumbo extract prepared by embodiment 3 or embodiment 4 is made compared with embodiment 1 or embodiment 2
There is standby gumbo extract more preferable effect of reducing blood sugar to use.
In sum, the gumbo extract that prepared by the present invention can be used to treat hyperglycaemia, and gumbo extract is pure natural
Material, over the course for the treatment of, fundamentally reduces blood sugar, the side effect without pharmacological dependence.
Embodiments of the invention are the foregoing is only, the scope of the claims of the invention is not thereby limited, it is every to utilize this hair
The equivalent transformation that bright description is made, or other related technical fields are directly or indirectly used in, similarly it is included in
In scope of patent protection of the invention.
Claims (9)
1. a kind of preparation method of gumbo extract, it is characterised in that comprise the following steps:
Dry gumbo is crushed to 90-100 mesh, gumbo dry powder is obtained;
The gumbo dry powder is taken, petroleum ether is added, it is well mixed using high-speed homogenization machine, filtered after degreasing, obtain filtrate;
Boiling water is added in the filtrate, solid-liquid ratio is 1:9-14, is well mixed, and 4.5-5.5h is extracted under boiling water state, from
The heart, collects supernatant;
The 4-5 times of absolute ethyl alcohol of volume is added in the supernatant carries out alcohol analysis, after standing 7-9h, centrifuging and taking precipitation;
The precipitation is dissolved in water, the aqueous solution is heated, it is boiling for 10-15min, treat the aqueous solution
After cooling, supernatant is collected in centrifugation, and the supernatant is spray-dried, and obtains gumbo extract.
2. the preparation method of gumbo extract according to claim 1, it is characterised in that the gumbo dry powder is 94 mesh.
3. the preparation method of gumbo extract according to claim 2, it is characterised in that the degreasing number of times of the petroleum ether
It is 2 times or more than 2 times.
4. the preparation method of gumbo extract according to claim 3, it is characterised in that the material of the filtrate and boiling water
Liquor ratio is 1:10, extraction time is 5h.
5. the preparation method of gumbo extract according to claim 4, it is characterised in that using physiological saline to the autumn
Certain herbaceous plants with big flowers extract is fully dissolved, and then carries out gel filtration chromatography, is eluted using physiological saline, the elution amount of physiological saline
It is 2-3BV, collects eluent, adds the 4-5 times of absolute ethyl alcohol of volume to carry out alcohol analysis in eluent, after standing 7-9h, centrifugation
Precipitation is taken, the gumbo extract of purifying is obtained.
6. the preparation method of gumbo extract according to claim 4, it is characterised in that the solid-liquid ratio is g:ml.
7. the gumbo extract that the preparation method described in claim 1-6 any one is prepared.
8. the gumbo extract described in claim 7 as hypoglycemic drug or health products application.
9. application according to claim 8, it is characterised in that the gumbo extract is used as hypoglycemic drug or health products
Formulation be tablet, capsule, granule or powder.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710262881.8A CN106890203A (en) | 2017-04-20 | 2017-04-20 | A kind of gumbo extract and its preparation method and application |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710262881.8A CN106890203A (en) | 2017-04-20 | 2017-04-20 | A kind of gumbo extract and its preparation method and application |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106890203A true CN106890203A (en) | 2017-06-27 |
Family
ID=59197416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710262881.8A Pending CN106890203A (en) | 2017-04-20 | 2017-04-20 | A kind of gumbo extract and its preparation method and application |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106890203A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107496473A (en) * | 2017-08-11 | 2017-12-22 | 广东维尼健康科技有限公司 | Application of the okra water extract in digestive tract function is protected |
CN110885383A (en) * | 2019-11-08 | 2020-03-17 | 广西轻工业科学技术研究院有限公司 | Method for preparing okra mucopolysaccharide |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102670673A (en) * | 2012-05-21 | 2012-09-19 | 信毅投资咨询(上海)有限公司 | Application of active ingredients of gumbo in preparation of medicaments for preventing and treating metabolic diseases |
CN106832027A (en) * | 2016-12-30 | 2017-06-13 | 浙江海洋大学 | The extracting method of gumbo polysaccharide |
-
2017
- 2017-04-20 CN CN201710262881.8A patent/CN106890203A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102670673A (en) * | 2012-05-21 | 2012-09-19 | 信毅投资咨询(上海)有限公司 | Application of active ingredients of gumbo in preparation of medicaments for preventing and treating metabolic diseases |
CN106832027A (en) * | 2016-12-30 | 2017-06-13 | 浙江海洋大学 | The extracting method of gumbo polysaccharide |
Non-Patent Citations (1)
Title |
---|
郑云云等: "黄秋葵果荚中多糖的提取及其累积规律", 《福建农业学报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107496473A (en) * | 2017-08-11 | 2017-12-22 | 广东维尼健康科技有限公司 | Application of the okra water extract in digestive tract function is protected |
CN110885383A (en) * | 2019-11-08 | 2020-03-17 | 广西轻工业科学技术研究院有限公司 | Method for preparing okra mucopolysaccharide |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Kochhar et al. | Effect of supplementation of traditional medicinal plants on blood glucose in non–insulin-dependent diabetics: A pilot study | |
WO2015172608A1 (en) | Capsule for assisting in reducing blood fat and preparation method therefor | |
CN109700011A (en) | A kind of health food and preparation method thereof improving sleep | |
CN105267755A (en) | Blood-glucose-reducing oral liquid | |
CN105341893A (en) | Composition for assisting in reducing blood glucose and application | |
CN106890203A (en) | A kind of gumbo extract and its preparation method and application | |
CN104857154A (en) | Traditional Chinese medicine composition for treating three-high diseases and preparation method therefor | |
CN102114170B (en) | Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof | |
CN103815397B (en) | Downgrade food compositions of blood pressure, blood fat and blood sugar and preparation method thereof | |
CN106692742A (en) | Traditional Chinese compound medicine for regulating blood sugar and preparation method of traditional Chinese compound medicine | |
CN108524811A (en) | Reduce uric acid, cholesterol, three high Chinese medicine compositions and its preparation method for the treatment of | |
CN100542597C (en) | A kind of Chinese medicine preparation technology who treats vocal nodule, polyp of vocal cord symptom and uses thereof | |
CN109350644A (en) | Auxiliary hyperglycemic tablet | |
CN102614243B (en) | Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines | |
CN108403818A (en) | A kind of composition of auxiliary hyperglycemic and application thereof | |
CN101564465A (en) | Chinese medicinal composition for nourishing blood, benefiting vital energy, regulating menstruation and dissipating cold | |
CN101653499B (en) | New application of peony blood stasis removing preparation in preparing medicaments for preventing or treating diabetic complication | |
CN104256618B (en) | A kind of hypoglycemic food, health products or pharmaceutical composition | |
CN104127816B (en) | A kind of pharmaceutical composition for treating diabetes and its production and use | |
CN107537028A (en) | A kind of while auxiliary hyperglycemic and the formula of hypotensive and preparation method thereof | |
CN106928376A (en) | The separation method of skunk bush polysaccharide and its application | |
CN112089784A (en) | Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diseases caused by atherosclerosis | |
CN110507759A (en) | A kind of three yellow Chinese herbal preparation of particles and preparation method thereof with control hyperglycemia | |
Zafar et al. | Exploring the Effects of Celery Stem on Blood Pressure, and Associated Parameters as Social Determinants in Hypertensive Individuals: A Randomized Control Trail | |
CN109620913A (en) | It is a kind of to prevent and/or treat fat, hyperglycemia composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170627 |