CN106880494A - Prevent the package component of premature activation - Google Patents
Prevent the package component of premature activation Download PDFInfo
- Publication number
- CN106880494A CN106880494A CN201710063621.8A CN201710063621A CN106880494A CN 106880494 A CN106880494 A CN 106880494A CN 201710063621 A CN201710063621 A CN 201710063621A CN 106880494 A CN106880494 A CN 106880494A
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- China
- Prior art keywords
- container
- shell
- projection
- main body
- component
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/326—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming one compartment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
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- Health & Medical Sciences (AREA)
- Composite Materials (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
Abstract
The present invention relates to a kind of package component (10) for preventing premature activation for medicine reconstitution component (100), it includes main body (14), medicine reconstitution component (100) and removable cover (12).The main body includes multiple projections (16,18), the multiple projection is configured to match the corresponding part of multiple of the medicine reconstitution component, so as to suppress the translation axially and in rotation of the medicine reconstitution component and its part during transport and treatment.By preventing from during transporting moving axially and in rotation, minimize medicine or puncture too early and unexpected puncture or pollution in the medicine reconstitution component.
Description
The application be the Application No. 201280070539.3, applying date on 2 22nd, 2012, entitled " prevent too early
The divisional application of China's application of the package component of activation ".
Technical field
The disclosure relates generally to a kind of medical package device assembly, and relates more specifically to the group of packaging and medical treatment device
Close.
Background technology
Certain drug is supplied with lyophilized form.Freeze-dried drug must mix with water, medicine is reformulated and is adapted to injection
To the form in patient's body.Especially, the component for forming Injectable solution must be aseptic, to avoid infection.Regrouping process is given to be needed
Want oneself or proposed by patient or care-giver that other people are injected (such as in residential environment) difficult.Patient or care-giver must abide by
The order operation of medicament reservoir, cut-back tank and transfer syringe is followed, patient or care-giver use needle pierces and corresponding container
The bottle stopper of association.Patient or care-giver need to follow the sterile working established, to avoid pollution.
Such as U.S. Patent application No.13/217, described in 967 (" ' 967 ' applications "), the disclosure of which is herein by quoting
It is integrally incorporated with it, when terminal user is transported to from manufacturer, retailer or assembler, the medicament reservoir of device, dilution are held
Device and transfer syringe are installed in same housing.Because transfer syringe is relative to each medicament reservoir in medicament reservoir
Specific arrangements, so want SC, to prevent during shipment and operation, by container bottle stopper caused by transfer syringe
It is unexpected to pierce through too early or activate.Therefore, the transport of reconstruction unit is challenged in terms of the premature activation for preventing product, so that really
Protect aseptic and cause that terminal user is readily able to use product.Freeze-dried drug is generally very expensive so that received during transport
The unexpected activation or pollution arrived are minimum even more important.
The content of the invention
Disclosure offer is a kind of including packaging and reconstitution component and the package component of related medical product, the packages groups
Part prevents the premature activation of reconstitution component.The packaging is shaped to seem that reconstitution component is placed in cradle.The packaging is integrated with weight
The associated components of group component, and during shipment and operation, maintain the various pieces of reconstitution component to be isolated from each other in packaging.
In one embodiment, reconstitution component includes shell, and the shell has upper sleeve pipe and setting of casing.Shell is limited substantially
Tubular conduit, and include multiple radially spaced holes in upper sleeve pipe and include multiple radially spaced windows in setting of casing
Mouthful.Transfer suit component is arranged in shell, is between sleeve pipe and setting of casing.Transfer suit component is relative including a pair
Puncture, the pair of relative puncture includes lower puncture and upper puncture.Upper and lower puncture forms a part of flow path.
First container is disposed at least partially in the upper sleeve pipe of shell, in passage and near upper puncture.The
One container includes the first bottle and the first bottle stopper, and the first bottle stopper provides aseptic to the medical content thing being maintained in the first bottle
Barrier.In one embodiment, the first container is arranged such that, the first bottle stopper downwards or faces the center of shell.Second
Container is disposed in setting of casing, in passage and near lower puncture.Second container includes the second bottle and the second bottle stopper, the
Two bottle stoppers provide sterile barrier to the content of the second bottle.In one embodiment, second container is arranged such that, second
Bottle stopper is upward towards the first bottle stopper.The flow path formed by puncture allows container fluid communication with each other when being punctured.
In embodiment, once applying the first power to the first container, then the upper puncture for shifting suit component just pierces through first
Bottle stopper.The patient being pressed down against or care-giver that the power can be come on comfortable first container, so as to the first container is pushed into shell
In and shift onto in puncture.After upper the first bottle stopper for puncturing the first container of puncture, it is allowed to which second container covers relative to transfer
Arrangement is moved axially.Then, once applying the second power, and by the first container and particular by the first of the first container
Bottle is engaged with trigger mechanism, and the second bottle stopper is just pierced through in the lower puncture for shifting suit component.When the second bottle stopper is pierced, just enter
Enter the vacuum of second container.First and second power can be predetermined power, or can be at aspiration level.
In embodiment, the fenced liquid of the first container, and the fenced freeze-drying prods of second container.The is pierced through using upper puncture
First bottle stopper of one container, and using lower the second bottle stopper for puncturing and piercing through second container, make the first and second containers pass through to turn
Move suit component flow path and fluid communication with each other.Then, the vacuum of second container causes the liquid of the first container to pass through
In fluid passage suction second container.Liquid mixes with freeze-dried drug, to be formulated for the medicine that patient uses.
Package component is constructed such that reconstitution component coordinates in packaging, and the packaging physically suppresses first
The axial translation of container or second container in shell.By any obvious axle of suppression first or second container in shell
To translation, prevent the first bottle stopper of the first container unexpected or too early by lower puncture by the second bottle stopper of upper puncture or second container
Puncture.
In embodiment, the packaging includes internal chamber, and the internal chamber is formed with multiple recessed and projections, the plurality of recessed
Enter the matching block complementation being shaped to projection with reconstitution component.The internal chamber of the packaging is formed so that, reconstitution component with
Pre-determined configurations suitably engage the complementary recessed and projection of the packaging.For example, having first and second in the end of packaging
Recessed, first and second recessed hug the first and the of the first and second containers that (cradle) extends from the shell of reconstitution component
Two bottles.The multiple projections in the internal chamber of the packaging are extended to match and extend through following multiple holes, i.e. restructuring group
The multiple holes in multiple holes and setting of casing in the upper sleeve pipe of the shell of part.
The projection of the hole permission package main body in shell is extended in the passage formed by shell, and the hole is around bottle
The part engagement bottle of neck, the bottle can be the vial with neck opening.Projection tangles the hole of shell, so as to
Prevent the first and second corresponding containers from rotating within a package.The engagement of projection and vial neck be also prevented from container relative to each other,
Relative to transfer suit component or the unintentionally axial translation relative to shell.By keeping the first and second containers relative to that
This and it is substantially axial static relative to transfer suit component, the projection of the internal chamber of package main body maintains to puncture and lower puncture
At one separating distance of each container being respectively in the first container and second container.Due to minimizing or preventing
The axial translation of the part of reconstitution component during shipment and operation, so the corresponding puncture for also minimizing transfer suit component causes
The first and second containers too early puncture situation.
Other feature and advantage are described herein, and these other spies will be understood with accompanying drawing by being detailed below
Seek peace advantage.
Brief description of the drawings
Fig. 1 is the perspective view of one embodiment of the packaging of the assembling of the disclosure.
Fig. 2 is of packaging, the reconstitution component that is accommodated in the packaging and the lid for the packaging of the disclosure
The exploded view of embodiment.
Fig. 3 is the view of the main body side of one embodiment of the packaging and medicine reconstitution component of the assembling of the disclosure.
Fig. 4 is the sectional view of the packaging of the assembling of the line IV-IV interceptions along Fig. 3 of Fig. 3.
Fig. 5 is the bottom view of one embodiment of the packaging of the disclosure.
Fig. 6 is the sectional view of the packaging of the line VI-VI interceptions along Fig. 5 of Fig. 5.
Fig. 7 is the side view of one embodiment of the packaging of the assembling of the disclosure.
Fig. 8 is the end-view of one embodiment of the packaging of the assembling of the disclosure.
Specific embodiment
Present disclose provides a kind of including the packaging for assembling and the package component of reconstitution component.Package component is used in particular for preventing
The only premature activation of the reconstitution component during shipment and operation.Although package component is primarily described as including weight herein
Group component, it will be understood that have during the other medicines component of component of preceding separation or other products is used transporting, can
To use the packaging of appropriate structuring.
With reference now to accompanying drawing and particularly Fig. 1 and 2, wherein substantially indicating the packaging 10 of assembling.The packaging 10 of assembling is substantially
Including removable cover 12, main body 14 and medicine reconstitution component 100 (Fig. 2).
Removable cover 12 can be by any one or more hdpe fiber such asFoil material
Or paper material is made, and in one embodiment, removable cover 12 is adhered to main body 14 by heat-activated adhesive.
Adhesive and applying process cause that removable cover 12 keeps firmly adhering to main body 14, but also can be by patient relatively easily
Remove.
Main body 14 can be constructed by PET (" PET ") material of heat deformable.Main body 14 can lead to
Cross projection 16,18, well shape portion (well) 20a to 20c etc. of thermoforming process formation and form the intended shape of main body 14.Replacing
For in embodiment, main body 14 is made up of polymeric material, and is molded by Shooting Technique.
As shown in figs. 1 and 2, lid 12 hermetically and is removably attachable to main body 14, so as to by the envelope of reconstitution component 100
Enclose in packaging 10.Removable cover 12 can provide flat surface, can be shown on the flat surface manufacturer instruction and
Identification information.Information identifier may include bar code, figure code, company information and internet address, to direct the user to
More detailed information.The information may include medical information, patient's identification and prescription information, manufacturer's information, license and government organs
Information, production and expiration date information and instruction.
As shown in figs. 1 and 2, main body 14 is formed to define internal chamber, and internal chamber is more in chamber including being projected into
Individual projection 16 and 18 and the well shape portion 20a to 20c for internally extending from chamber.These are more fully hereinafter described special
Levy.Projection used herein extends generally towards the center of the internal chamber of main body 14, and well shape portion is substantially from the inside of chamber
Center extends out.
Internal chamber receives the medicine reconstitution component 100 illustrated in Fig. 2.Medicine reconstitution component 100 includes shell 110, should
Shell 110 have upper part 112 (when remain use when) and low portion 114 (when remain use when).Upper part
112 and low portion 114 formed substantial cylindrical passage.Medicine reconstitution component 100 also includes：Upper container 120 (makes when remaining
Used time), upper container 120 is at least partly accommodated in the passage formed by the upper part 112 of shell；Lower container 130 (when
Remain when using), lower container 130 is at least partly accommodated in the passage formed by the low portion 114 of shell；With connect
Port plug 140 is touched, the contact port plug 140 is arranged on the outside of shell 110.The removable cover 12 of packaging 10 is hermetically
Main body 14 is attached to, so as to medicine reconstitution component 100 is enclosed in main body 14.
With reference now to Fig. 3, the view of the main body side from the packaging 10 of the assembling of outer observation is shown.First pair of projection 16 and
Two pairs of projections 18 extend to internal chamber from main body 14 around surface, so as to contact the matching part of medicine reconstitution component 100
Part.Well shape portion 20a, 20b and 20c stretching out from internal chamber around surface relative to main body 14.Well shape portion 20a, 20b and
20c is at least substantially flat, and (referring also to Fig. 1 and 2) coplanar with each other, is arranged on surely well shape portion 20a, 20b and 20c with will pass through
Determine on surface, can sit packaging 10 and be placed on main body side.As shown in Fig. 1 to 3, main body 14 is also in the upper end of main body 14 with
Well shape portion 22 and 24 is formed at end.
With reference now to Fig. 4, exemplified with the cross-sectional side view that the line IV-IV along Fig. 3 is intercepted.Due to the radial direction with projection 18
The spaced radial and geometric shape of the projection 16 that interval compares with geometric shape, have been exaggerated for line IV-IV in figure 3, from
And both cross sections of projection 16 and 18 are preferably shown in the single view of Fig. 4.Reconstitution component 100 and its shell 110
Content of the cross-sectional view exemplified with reconstitution component.Specifically, reconstitution component 100 include first upper container 120, second or under
Container 130 and transfer suit component 200.
Such as it is incorporated herein by reference what is discussed in detail in this ' 967 are applied, transfer suit component 200 includes above wearing
Thorn 202, the lower flow paths for puncturing 204 and being advanced through upper puncture 202 and lower puncture 204.It is upper to puncture 202 in face of upper container
120 opening 128, and lower puncture 204 is in face of the openings 138 of lower container 130.In various embodiments, suit component 200 is shifted
Parts of plastics be made up of appropriate moldable and sterilizable plastics, such as acrylonitrile-butadiene-styrene copolymer
(" ABS "), makrolon (" PC ") or acrylic acid.
Upper puncture 202 can include upper protective cover (upper boot) 206, and protective cover 206 is configured to covering on this
With the low portion and the aseptic of the flow path part of upper puncture punctured in maintenance.Similarly, it is lower to puncture 204 including lower anti-
Shield 208, the low protection cover 208 is configured to cover and maintain down the nothing of the upper part and flow path part in puncturing
Bacterium property.In one embodiment, upper and lower protective cover 206,208 is made up of elastomeric material, once activation medicine reconstitution component
100, then go up 206 and lower 208 protective cover be relatively easy to respectively by it is upper puncture 202 and it is lower puncture 204 pierce through.
Transfer suit component 200 can also include syringe ports path (as shown in Figure 2, under stopper 140), note
Emitter port path be approximately perpendicular to through it is upper puncture 202 and it is lower puncture 204 advance flow paths and maintain with pass through above wear
Thorn 202 and the lower fluid communication equipped with valve for puncturing 204 flow paths advanced.Syringe ports path can not hang down alternatively
Directly the flow path from transfer suit component 200 extends.Syringe ports path and the shell 110 through reconstitution component 100
The syringe ports connection of extension.In fig. 2, the engagement of syringe ports plug 140 syringe ports, in maintaining port and connect
Fluid path aseptic.
After activation medicine reconstitution component 100 completely, user removes syringe ports plug 140, to expose syringe ports,
So that user can be contacted by separate syringe.Syringe ports plug 140 is made up of elastomeric material or elastomeric material, with
Just syringe ports plug 140 can bend, to grasp and remove.Syringe ports path and puncture flow path are allowed from injection
Device port to upper and lower container 120,130 fluid communication.
Upper and lower part container 120,130 includes upper and lower part bottle 121,131, for example, upper and lower bottle 121,131
By appropriate medical grade can bactericidal glass or plastics be made.Upper bottle 121 and lower bottle 131 all substantially cylindricals, and tool
There are similar geometric shape, including neck portion 122a, 132a, main part 122c, 132c and marginal portion 126,136.Neck
The diameter that part 122a, 132a have is less than main part 122c, 132c or marginal portion 126,136.Upper bottle stopper 124 is hermetically
The upper shed 128 of bottle 121 is clogged, so as to prevent pollution or the seepage of the content of upper container 120.Similarly, lower bottle stopper
134 under sheds 138 for hermetically clogging lower bottle 131, so as to prevent pollution or the seepage of lower container 130.Upper bottle stopper 124 is with
Bottle stopper 134 can be made up of rubber or elastomeric material.It should be appreciated that the component of upper bottle 121 and upper bottle stopper 124 is determined herein
Justice is upper container 120.Similarly, herein by the component definition of lower bottle 131 and lower bottle stopper 134 be lower container 130.
The shell 110 of reconstitution component 100 includes upper case portion 112 and lower housing section 114, the He of upper case portion 112
Lower housing section 114 also can be by acrylonitrile-butadiene-styrene copolymer (" ABS "), makrolon (" PC ") or acrylic acid
It is made.Upper case portion 112 includes or defines multiple holes 116, and lower housing section 114 includes or defines multiple holes 118 (as schemed
In 2 best seen from).Hole or window 116 and 118 all separate around corresponding shell spaced radial.Hole 116,118 allows sterilizing air
Body flows to the component of interior section and reconstitution component 100.In addition to being easy to sterilization treatment, when being accommodated in restructuring shell
When in 110, hole 116,118 provides at least partly contact to top 120 and the container of bottom 130.
Discussed in detail in applying such as ' 967, once activating medicine reconstitution component 110, upper puncture 202 is just pierced through and prevented
Shield 206 and top bottle stopper 124, it is afterwards, lower to puncture the 204 puncture Hes of low protection cover 208 to contact the content of upper container 120
Lower bottle stopper 134, to contact the content of lower container 130.When it is upper and lower puncture 202,204 respectively contact top 120 and under
During the content of container 130, just flow path is produced between upper container 120 and lower container 130.The application of ' 967 discusses component
110 other internal mechanisms, these internal mechanisms ensure that upper container 120 punctures 202 and advances towards top, and are punctured in bottom
Before the 204 lower bottle stoppers 134 that can contact lower container 130, upper bottle stopper 124 punctures 202 and pierces through completely by top.
Exemplified with during (unactivated state) is transported, how container 120 and 130 coordinates in medicine reconstitution component 100 Fig. 4
Shell 110 in, and how medicine reconstitution component 110 to coordinate in the internal chamber of package main body 14.As illustrated, upper appearance
Device 120 coordinates in upper case portion 112 at least in part.The upper limb 126 and upper bottle stopper 124 of upper bottle 121 all by towards turn
Move suit component 200 and upper puncture 202 is oriented.In shown unactivated state, the upper bottle stopper 124 of upper container 120 is arranged
202 are punctured near upper, but does not contact puncture 202.
Upper case portion 112 in one embodiment is included around the substantially homogeneously radial arrangement of upper case portion 112
Three holes 116, as partially shown in fig. 2.It should be appreciated that any number of hole can be included in upper case portion 112, and it is spaced
Do not need equal or for radial direction.Upper case portion 112 is formed so that, is transported under construction when upper container 120 is fixed on it
When, all parts of upper bottle 121, all as above shoulder 122b, upper neck 122a and upper limb 126 are all longitudinally aligned with hole 116.
Similar with upper container 120, lower container 130 coordinates in lower housing section 114 at least in part.Lower bottle 131
Lower edge 138 and lower bottle stopper 134 are all oriented by the lower puncture 204 towards transfer suit component 200.In unactivated state (such as figure institute
Show) in, the lower bottle stopper 134 of lower container 130 is disposed adjacent to lower puncture 204, but is worn under not contacting transfer device assembly 200
Thorn 204.
Lower housing section 114 in one embodiment includes six evenly radially arranged around lower housing section 114
Hole 118, as partially shown in fig. 2.Any number of hole can be included in lower housing section 114, and it is described any number of
Hole need not be by equal or to be radially spaced.In fig. 4, two holes 118 in the hole 118 of lower housing section 114 are visible.Under
Housing parts 114 are formed so that container 130 is fixed on it and transports when under construction instantly, all parts of lower bottle 131,
All following shoulder 132b, low portion of neck 132a and lower edge 136 are all longitudinally aligned with hole 118.
Importantly, before user intentionally activates medicine reconstitution component 100, upper container 120 and lower container 130 are not moved
The dynamic transport construction for departing from them.Upper container 120 or this of lower container 130 are not intended to transport, carry or carry by mistake caused by
Displacement, can cause to puncture 202 or lower puncturing 204 and go up contact too early between bottle stopper 124 or lower bottle stopper 134 with corresponding.
Even, the rupture or interference of relatively thin protective cover 206 and 208 can be also destroyed by turning caused by corresponding puncture 202 and 204
Move the gnotobasis of the flow path of the traveling of puncture 202 and 204 of suit component 200.As discussed in more detail below, 10 are packed
Prevent these undesirable displacements.
It should be appreciated that for the disclosure, it is undesirable to displacement definition be following part multiple Different Results positions in
Any one result position, i.e.,：Upper container 120 and lower container 130, upper 202 and lower 204 puncture, upper bottle stopper 124 and lower bottle stopper
134th, upper protective cover 206 and low protection cover 208, transfer suit component 200 and shell 110.By main body 14 and medicine restructuring group
The interaction of part 100, it is therefore prevented that can be in each in the undesirable displaced position surprisingly occurred during transporting.Hereafter
Several undesirable displaced positions are described.Although it should be appreciated that on both upper and lower containers discuss, it is contemplated that each is not
Desired displaced position is all either individually or collectively applied to top 120 and the container of bottom 130.
In the first undesirable displaced position, upper container 120 or lower container 130 are relative to the transfer axle of suit component 200
To skew so that upper bottle stopper 124 or lower bottle stopper 134 are contacted with upper protective cover 206 or low protection cover 208, upper protective cover 206 or under
Protective cover 208 is then contacted and respectively at least partially punctures 204 by upper puncture 202 or lower and pierces through.It should be appreciated that not wished first
In the displaced position of prestige, bottle stopper 124 or lower bottle stopper 134 on 202,204 incomplete penetrations are punctured accordingly.It is undesirable first
In displaced position, upper protective cover 206 and low protection cover 208 puncture 202 and the puncture of bottom puncture 204 by corresponding top so that
Transfer suit component 200 and its flow path vulnerable to pollution.
In the second undesirable displaced position, upper container 120 or lower container 130 are relative to the transfer axle of suit component 200
To movement so that upper bottle stopper 124 or lower bottle stopper 134 are contacted with upper protective cover 206 or low protection cover 208 respectively.Upper protective cover 206
Or low protection cover 208 is then crushed on upper puncture in 202 or lower punctures 204 by the axial translation of corresponding container.Second
In undesirable displaced position, upper puncture 202 or lower punctures 204 and all pierces through corresponding protective cover 206,208, and at least portion completely
Ground is divided to pierce through the bottle stopper 124,134 of corresponding container 120,130.In the second undesirable displaced position of various embodiments, wear
Thorn 202,204 pierces through corresponding bottle stopper 124,134 completely.In the second undesirable displaced position, upper bottle stopper 124 or lower bottle stopper
134 puncture 204 by upper puncture 202 or lower partially or completely pierces through, and causes to shift opportunities for contamination, the Yi Jirong of suit component 200
The opportunities for contamination increase of the content of device 120 or 130.
In the 3rd undesirable displaced position, upper container 120 or lower container 130 are relative to shell 110 axially or radially
Skew, so as to cause the seal failure between bottle 121,131 and the inside of shell 110.In the 3rd undesirable displaced position,
Failure sealing can reduce the strong fix of upper container 120 and lower container 130 in shell 110, thus improve too early axial direction
The possibility of translation, and cause other undesirable displaced position.
Before removable cover 12 is attached into main body 14, medicine reconstitution component 100 is inserted into the inner chamber of main body 14
In room.During this period, projection 16 and 18 and included by the matching of well shape portion 20a to 20c, 22 and 24 medicine reconstitution component 100,
And it is maintained at the different parts of upper container 120 and lower container 130 in medicine reconstitution component 100.
With reference now to Fig. 5 and 6, further illustrate projection and well shape portion.Well shape portion 20a, 20b and 20c from main body 14 to
Outer extension, and form substantially coplanar surface, can on the substantially coplanar surface support component 10.Well shape portion 20c is shaped to base
The contour shape of the syringe ports plug 140 of this matching medicine reconstitution component 100.In transporting position, syringe ports plug 140
The bottom of component is faced down towards, to match well shape portion 20c.Syringe ports plug 140 inhibits end with the engagement of well shape portion 20c
Mouth is in rotary moving in main body 14.Syringe ports plug 140 also matches well shape portion 20c, with provide on shell 100 relative to
The additional axial constraint of main body 14.By syringe ports plug 140 downwardly against component 100 lower end orientation prevent user to
After when peeling removable cover 12, medicine reconstitution component 100 is removed by syringe ports plug 140, this can result in plug 140 from
The possibility increase of syringe ports accidental separation.On the contrary, should just before by outer injectors coupling assembly 100 move
Except syringe ports plug 140.
In the internal chamber that Fig. 5 extends inward into main body exemplified with two projections 16 from package main body 14.Such as institute in Fig. 6
Show, projection 16 includes several geometric shape parts, these geometric shape parts are formed as being matched with medicine reconstitution component 100
Part cooperates.Especially, each projection 16 includes multiple faces, including tapered face 16a, lid side 16b, body side 16c,
16d and following 16e above.Fig. 1 clearly shows to 6, two projections 16 from the outside of main body 14, in the longitudinal center of main body 14
It is spaced on either side and is equally extended.
Fig. 2 shows how medicine reconstitution component 100 coordinates the exploded view in main body 14.When the quilt of medicine reconstitution component 100
When in insertion main body 14, two projections 16 extend through two respective apertures 116 of upper case portion 112.As shown in Figure 4, dash forward
16 are played to extend towards upper container 120 through hole 116.Especially, the body side 16c of projection 16 is constructed and arranged to engagement
The side 116a of the upper case portion 112 in hole 116 is formed, the lid side 16b of projection 16 is constructed and arranged to engage shape
The side 116b of the upper case portion 112 of pore-forming 116, above 16d be constructed and arranged to engage the upper shell to form hole 116
The side 116c of part 112, and 16e is constructed and arranged to engage the side of the upper case portion 112 to form hole 116 below
Face 116d.
Engagement between projection 16 and hole 116 prevents medicine reconstitution component 100 axial translation or rotation in main body 14.
Especially, lid side 16b contacts the side 116b of the upper case portion 112 to form hole 116, and body side 16c is contacted
The side 116a of the upper case portion 112 in hole 116 is formed, to prevent the rotation in main body 14 of medicine reconstitution component 100.It is similar
Ground, below 16e contact the side 116d of the upper case portion 112 to form hole 116, and 16d contacts to form the upper of hole 116 above
The side 116c of housing parts 112, to prevent the axial translation in main body 14 of medicine reconstitution component 100.
In various embodiments, projection 16 need not be held while the upper bottle 121 with upper container 120 is physically contacted
Continuous ground is contacted with side 116c, the 116d in hole 116 or has any contact with side 116c, the 116d in hole 116.It should be appreciated that projection
16 help to be firmly held in upper container 120 in upper case portion 112, because projection 16 inhibits upper container 120
Any axial dipole field, and suppress any axial dipole field of hole 116 (that is, upper case portion 112) by same projection 16.Due to
Projection 16 between hole 116 and upper container 120 upper bottle 121 neck 122a and edge 126 between extend, so projection
16 and therefore main body 14 prevents upper container 120 relative to the axial dipole field of upper case portion 112.
Similar with above-mentioned projection 16, main body 14 also includes two projections 18 at its lower end, and the two projections 18 are from main body
In 14 internal chambers for extending inward into main body.In figure 6, in projection 18 is illustrated in greater detail.It is identical with projection 16,
Projection 18 includes several geometric shape parts, and these geometric shape parts are sized and are arranged relative to main body 14, so that
When being inserted into packaging 10, the matching block with medicine reconstitution component 100 cooperates.Especially, projection 18 includes tapered face
18a, lid side 18b, body side 18c, following 18d and 18e above.Fig. 1 clearly shows to 6, and two projections 18 are from main body
14 inwardly, are spaced on the either side of the longitudinal center of main body 14 and equally extend.
Fig. 2 shows that when medicine reconstitution component 100 is inserted into main body 14 two projections 18 pass through lower housing section 114
Two respective apertures 118 extend.As shown in Figure 4, projection 18 extends through hole 118 towards lower container 130.Especially, projection
18 body side 18c is configured to engage the side 118a of the lower housing section 114 to form hole 118, the lid of projection 18
Side 18b is configured to engage the side 118b of the lower housing section 114 to form hole 118, below 18d be configured to engagement
The side 118c of the lower housing section 114 in hole 118 is formed, and 18e is configured to engage the lower house to form hole 118 above
The side 118d of part 114.
Engagement between projection 18 and hole 118 prevents medicine reconstitution component 100 axial translation or rotation in main body 14.
Especially, lid side 18b contacts the side 118b of the lower housing section 114 to form hole 118, and body side 18c is contacted
The side 118a of the lower housing section 114 in hole 118 is formed, to prevent the rotation in main body 14 of medicine reconstitution component 100.It is similar
Ground, below 18d contact the side 118c of the lower housing section 114 to form hole 118, and 18e contacts to be formed under hole 118 above
The side 118d of housing parts 114, to prevent the axial translation in main body 14 of medicine reconstitution component 100.
In various embodiments, projection 18 need not be held while the lower bottle 131 with lower container 130 is physically contacted
Continuous ground is contacted with side 118c, the 118d in hole 118 or has any contact with side 118c, the 118d in hole 118.It should be appreciated that projection
18 help to be firmly held in lower container 130 in lower housing section 114, because projection 18 inhibits lower container 130
Any axial movement, and suppress any axial movement of hole 118 (that is, lower housing section 114) by same projection 18.Due to
Projection 18 between hole 119 and lower container 130 lower bottle 131 neck 132a and edge 136 between extend, so prominent
Play 18 and therefore main body 14 prevents lower container 130 relative to the axial movement of lower housing section 114.
Therefore, projection 16 and 18 cooperates, to prevent axle of the shell 110 of medicine reconstitution component 100 in packaging 10
To with it is in rotary moving both.Although matching each two hole 116 and 118 respectively exemplified with each two projection 16 and 18, other
Embodiment includes that each projection 16 and 18 matches a corresponding hole 116 and 118, or more than each two projection 16,18
With more than two corresponding holes 116,118.It should be appreciated that for the reason for being discussed more fully in applying in ' 967, medicine restructuring
Internal mechanism in component 100 and rub for fixing upper container 120 and lower container 130 relative to shell 110.
In various embodiments, if upper container 120 or lower container 130 around medicine reconstitution component 100 longitudinal axis line footpath
To movement, it becomes possible to harm inner seals various in greater detail or component in ' 967 are applied.It should be appreciated that projection 20c,
16 and 18 cooperation, to prevent upper container 120 or lower container 130 in shell 110, or medicine reconstitution component 100 it is any its
Its part is unexpected in rotary moving in packaging 10.
Refer again to the upper bottle 121 and lower container 130 of Fig. 3 to 6, discussed further and Exemplary body 14 and container 120
Lower bottle 131 in each between matching relationship.Except the hole 116 and projection 18 of projection 16 and shell 110 are with addition to
The interphase interaction in the hole 118 of shell 110 is so that outside the motion for preventing above-mentioned shell 110, projection 16 also matches the difference of bottle 121
Part, and projection 18 also matches the different parts of lower bottle 131, to prevent the obvious motion of upper container 120 and lower container 130.
For the purpose, projection 16 and 18 all extends through respective aperture 116 and 118, to contact upper bottle 121 and lower bottle 131.Each
In kind of embodiment, upper container 120 and lower container 130 on shell 110 and more specifically respectively about upper case portion 112 and under
The axial translation of housing parts 114 is prevented by following engagement, i.e.,：Projection 16 simultaneously with the engagement in upper bottle 121 and hole 116, with
And the engagement simultaneously with lower bottle 131 and hole 118 of projection 18.
As described above, upper container 120 and lower container 130 are arranged such that, upper bottle 121 and lower bottle 131 it is respective
Shoulder 122b, 132b, neck 122a, 132a and edge 126,136 are aligned with each in hole 116,118 respectively.Shown
In embodiment, projection 16 is configured to contact three different pieces of bottle 121, i.e. shoulder 122b, neck 122a and edge
126.Similarly, three different pieces of the lower bottle 131 of the contact of projection 18, i.e. shoulder 132b, neck 132a and edge 136.Fig. 2
Show that port plug 140 ensure that hole 116 and 118 is suitably rotated, to receive projection 16 and 18 respectively.
The tapered portion 16c of the projection 16 of main body 14 is configured to the profile along the shoulder 122b of upper bottle 121, and because
This keeps shoulder 122b.Similarly, the tapered portion 18c of the projection 18 of main body 14 is configured to the shoulder along lower bottle 131
The profile of 132b, and therefore keep shoulder 132b.Accordingly, tapered portion 16a, 18a be also used for supporting bottle 121 and under
Each in bottle 131, to prevent the obvious translation of corresponding upper container 120 and lower container 130 in packaging 10 from moving
It is dynamic.In order to prevent bottle to be moved to undesirable displaced position, it should be apparent that, in various embodiments, tapered portion 16a, 18a is not
Need shoulder 122b, 132b of contact belt profile.Due to shoulder 122b, 132b belt profile property and tapered portion 16a,
The respective tapered shape of 16b, upper container 120 and lower container 130 are pushed and overcome inclined relative to main body 14 and shell 110
Move.The belt profile shape of main body is also provided and hugs effect, and the effect ensure that bottle 121 and lower bottle 131 and main body 14
Between be slidably matched.
In various embodiments, the lid side 16b of the projection 16 of main body 14 is arranged to towards the edge of upper bottle 121
The neck 122a of the upper bottle 121 between 126 and shoulder 122b extends.Lid side between wedging edge 126 and shoulder 122b
Face 16b is further used for preventing translational movement of the upper container 120 in packaging 10.Similarly, the lid side 18b quilts of projection 18
The neck 132b being configured to towards the lower bottle 131 between the edge 136 and shoulder 132b of lower bottle 131 extends.Wedging edge
Lid side 18b between 136 and shoulder 132b is further used for preventing translational movement of the lower container 130 in packaging 10.For
The bottle is prevented to be moved to undesirable displaced position, it should be apparent that, in various embodiments, lid side 16b, 18b need not
Continuous contact edge 126,136 and shoulder 122b, 132b.
It should be appreciated that although transfer suit component 200 is not necessarily the part of upper case 112 or lower case 114,
Partially due to connection of the transfer suit component 200 at syringe ports, so transfer suit component 200 is really relative to shell
Remains stationary.Therefore, it should be apparent that, for the above-mentioned similar principles on container 120,130 and shell 100, main body 14 and its prominent
Play a part of 16,18 also rise prevent upper container 120 and lower container 130 relative to transfer the axial translation of suit component 200.
Further, since the orientation of taper surface 116a, the 118a being formed in main body 14, if if what, then pushing
Upper container 120 and lower container 130, away from transfer suit component 200.As shown in figures 4 and 6, corresponding upper bottle 121 is with
Shoulder 122b, 132b of bottle 131 sit be placed on profile 116a, 118a respectively, and profile 116a, 118a are at an angle, so as to
When lacking all other axial barrier, upper container 120 and lower container 130 also can not be inside, or towards transfer suit group
Part 200, and in particular towards it is upper puncture 202 and protective cover 206 and it is lower puncture 204 and protective cover 208 offset, and enter
Undesirable displaced position.It should be appreciated that at least for prevention upper container 120 and lower container 130 relative to transfer suit component 200
The same cause of axial translation, prevents upper container 120 and lower container 130 from being axially relative to one another translation.
The end sections 22 of main body 14 are formed as, and when being mounted in packaging 10, support and constraint medicine reconstitution component
100 different parts.Fig. 4 shows that the end sections 22 of main body 14 are configured to：By the upper bottle 121 of limitation axially upwardly
Move to constrain upper container 120.End sections 22 also support the base segments 122c of bottle 121.Similarly, main body 14
End sections 24 are configured to：Bottle 131 moves to constrain lower container 130 axially downwards under by limiting.End sections 24
Also the base segments 132c of lower bottle 131 is supported.It should be appreciated that some embodiments include main body 14, the tolerance of main body 14 is so
So that end sections 22,24 are contacted or the close respective base for contacting upper bottle 121 and lower bottle 131 respectively.In various realities
Apply in example, end sections 22,24 do not contact the bottom of upper bottle 121 and lower bottle 131 respectively.
By it is discussed above it should be appreciated that formed main body 14 geometric shape and part at multiple contact positions with it is following
Part interacts：(i) medicine reconstitution component 100, to prevent the rotation and translation of medicine reconstitution component 100 from moving；On (ii)
Container 120 and lower container 130, to be moved to undesirable bit shift with preventing upper container 120 and the lower rotation and translation of container 130
Put.
The each side of purport as herein described can be used alone, or can be with one or more of the other side specifically described herein
Face is applied in combination.In the case where described above is not limited, in the first aspect of the disclosure, a kind of medical package component bag
Include：Medicine reconstitution component, the medicine reconstitution component includes that (i) forms the shell at least one hole, (ii) and put at least in part
The container and (iii) put in the inside of shell are disposed in shell so as to puncture the piercing assembly of container；And main body,
The main body is shaped so that receiving medicine reconstitution component, and the main body includes extending through hole and extending in the inside of shell extremely
A few projection, wherein at least one projection be positioned and be arranged to reached in container it is undesirable relative to piercing assembly
Before displacement, prevent container from being moved towards piercing assembly.
According to the second aspect that can be used with reference to first aspect of the disclosure, the second aspect includes lid, and the lid is attached
It is connected to main body and is configured to be hermetically sealed on medicine reconstitution component in main body.
According to the third aspect that any one or more above-mentioned aspects are used that combines of the disclosure, wherein viscous by hot activation
Lid is attached to main body by mixture.
The fourth aspect that uses of any one or more above-mentioned aspects is combined according to the disclosure, wherein this at least one is dashed forward
Rise and be configured to prevent container relative to the axial translation of shell.
According to the disclosure combine any one or more above-mentioned aspects use the 5th aspect, wherein this at least one dash forward
Rising further prevents medicine reconstitution component from being rotated in main body.
According to the disclosure combine any one or more above-mentioned aspects use the 6th aspect, wherein main-body structure have to
A few flat surface, to prevent main body from rolling.
According to the 7th aspect that any one or more above-mentioned aspects are used that combines of the disclosure, wherein medicine reconstitution component
Including syringe ports plug, and main body includes cavity, and the cavity is shaped to match the syringe ports plug of medicine reconstitution component.
According to the eighth aspect that any one or more above-mentioned aspects are used that combines of the disclosure, the wherein container is first
Container, and the disclosure includes the second container being placed at least partly in the shell of medicine reconstitution component, the outer hull shape
Into at least one second holes, wherein at least one projection is the first projection, and the disclosure includes the second projection, and this second is dashed forward
Rise and be positioned and be arranged through during the second hole extends and extend to the inside of shell, and reached relative to wearing in second container
Before piercing the undesirable displacement of component, the second projection prevents second container from being moved towards piercing assembly.
According to the 9th aspect that any one or more above-mentioned aspects are used that combines of the disclosure, wherein the container is to include
First bottle of neck and shoulder, first container is arranged relative to shell, so that the neck of the first bottle of at least a portion
Portion is aligned with described at least one first holes, and at least one first projection is configured to be reached relative to puncture in the first bottle
Before the undesirable displacement of component, extend towards neck, and engaging shoulders.
According to the tenth aspect that any one or more above-mentioned aspects are used that combines of the disclosure, wherein the container is first
Container, and the disclosure includes the second container being placed at least partly in the shell of medicine reconstitution component, and second holds
Device is the bottle for including neck and shoulder, and shell forms at least one second holes, and the second container is arranged relative to shell, from
And the neck of at least a portion second container and at least one second holes are directed at, wherein at least one projection is first prominent
Rise, and main body forms the second projection, and second projection is positioned and is arranged through the second hole and extends and towards second container
Neck extend to the inside of shell, and before the undesirable displacement that second container reaches relative to piercing assembly,
Second projection engages the shoulder of second container.
According to the tenth one side that any one or more above-mentioned aspects are used that combines of the disclosure, a kind of drug delivery is produced
Product include：Medicine reconstitution component, the medicine reconstitution component includes shell and the container being placed in shell；And packaging, the bag
Dress includes being shaped to the main body for accommodating medicine reconstitution component and at least one projection extended from main body, at least one projection quilt
Positioning and arrangement are used to engage shell and container, to prevent container relative to the axial translation of shell.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
12 aspects, the wherein container is the first container, and the disclosure includes the second container being placed in shell, and projection is the
One projection, main body includes the second projection, and second projection is positioned and is arranged to engage shell, with prevent second container relative to
The axial translation of shell.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
13 aspects, wherein the first projection engages shell in the first position adjacent with the first container, and the second projection is with the
The adjacent second position engagement shell of two containers.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
14 aspects, wherein the first and second engagements include the first and second projections, first and second projection is each passed through shell
The first and second holes extend.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
15 aspect, wherein exist it is following at least one：I () first hole is in radially spaced multiple first holes of shell
One of, or (ii) second hole is around one of radially spaced multiple second holes of shell.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
16 aspects, wherein the first and second projections extended through the first and second holes further prevent shell relative to the rotation of main body
Transfer is dynamic.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
17 aspects, wherein the first and second containers are contacted by shifting suit component, the transfer suit component include can by with
The port of family contact, main body includes being positioned and arranging to engage the well shape portion of port, or including clogging the stopper of the port,
So as to prevent the axial movement of shell.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
18 aspects, wherein medicine reconstitution component also prevent shell from being moved relative to the rotation of main body by the engagement of at least one projection
It is dynamic.
According to combine that the tenth one side and one or more above-mentioned aspect any one are used together the of the disclosure
19 aspects, wherein medicine reconstitution component also prevent shell from being transported relative to the axial direction of main body by the engagement of at least one projection
It is dynamic.
According to the 20th aspect that one or more above-mentioned aspect any one are used that combines of the disclosure, one kind packaging
The method of medicine reconstitution component includes：The packaging with removable cover and main body is provided, the main body is configured to accommodate medicine
Thing reconstitution component, the main body includes at least one projection extended from main body；Medicine reconstitution component, the medicine reconstitution component are provided
With the shell including at least one hole and the container that is at least partially disposed in shell, wherein the neck portion of container with
At least one of hole of shell hole is aligned；By the assembling of medicine reconstitution component in the main body of packaging, so as at least the one of main body
Individual to protrude through the extension of at least one of hole of shell hole, wherein medicine reconstitution component orientation within a package is restricted to pre-
Fixed number purpose is oriented；With by removable cover, medicine reconstitution component is sealed in the main body of packaging.
It should be understood that for those skilled in the art, the various change and modification of presently preferred embodiments described herein are
Obviously.This can be made in the case where not departing from the spirit and scope of the present invention and not reducing its intentional advantage
A little changes and modification.Therefore, appended claims are intended to these changes and modification.
Claims (20)
1. a kind of medical package component, the package component includes：
Medicine reconstitution component, including：
I () shell, the shell forms at least one hole,
(ii) container, the container is placed at least partly in the inside of the shell, and
(iii) piercing assembly, the piercing assembly is disposed in the shell, so as to puncture the container；With
Main body, the main body is shaped to accommodate the medicine reconstitution component, and the main body includes extending through the hole and extending
At least one of inside to shell projection, wherein at least one projection is positioned and arranges in the appearance
Before device reaches the undesirable displacement relative to the piercing assembly, prevent the container from being moved towards the piercing assembly.
2. medical package component according to claim 1, the package component includes lid, and the lid is attached to described
Main body and it is configured to be hermetically sealed on the medicine reconstitution component in the main body.
3. medical package component according to claim 2, wherein the lid is attached into institute using heat-activated adhesive
State main body.
4. medical package component according to claim 2, wherein at least one projection is configured to prevent described
Axial translation of the container relative to the shell.
5. medical package component according to claim 1, wherein at least one projection further prevents the medicine
Reconstitution component rotates in the main body.
6. medical package component according to claim 1, wherein the main-body structure has at least one flat surface, so as to
Prevent the main body from rolling.
7. medical package component according to claim 1, wherein the medicine reconstitution component includes syringe ports plug, and
And the main body includes cavity, the cavity is shaped to match the syringe ports plug of the medicine reconstitution component.
8. medical package component according to claim 1, wherein the container is the first container, and the medical package
Component includes the second container being placed at least partly in the shell of the medicine reconstitution component, and the shell is formed
At least one second holes, wherein at least one projection is the first projection, and the medical package component includes that second dashes forward
Rise, second projection is positioned and is arranged through during second hole extends and extend to the inside of the shell, and
Before the undesirable displacement that the second container reaches relative to the piercing assembly, second projection prevents described
Two containers are moved towards the piercing assembly.
9. medical package component according to claim 1, wherein the container is the first bottle for including neck and shoulder,
First container by relative to the shell arrangement so that at least a portion neck of first bottle with it is described
At least one first holes are aligned, and described at least one first projections are configured to be reached in first bottle and are worn relative to described
Before piercing the undesirable displacement of component, extend and engage the shoulder towards the neck.
10. medical package component according to claim 9, wherein the container is the first container, and the medical treatment bag
Arrangement includes being placed at least partly second container in the shell of the medicine reconstitution component, and described the
Two containers are the bottles for including neck and shoulder, and the shell forms at least one second holes, the second container by relative to
The shell arrangement, so that at least a portion of second container neck is aligned with described at least one second holes,
Wherein described at least one projection is the first projection, and the main body forms the second projection, second projection be positioned and
It is arranged through that second hole extends and the neck towards the second container extends to the inside of the shell, and
And before the undesirable displacement that the second container reaches relative to the piercing assembly, the second projection engagement is described
The shoulder of second container.
A kind of 11. drug delivery products, including：
Medicine reconstitution component including shell and the container being placed in the shell；With
Packaging, the packaging includes being shaped to accommodate the main body of the medicine reconstitution component, and extends at least from the main body
One projection, at least one projection is positioned and arrangement is used to engage the shell and the container, to suppress the appearance
Axial translation of the device relative to the shell.
12. drug delivery products according to claim 11, wherein the container is the first container, and the medicine is defeated
Sending product includes the second container being placed in the shell, and the projection is the first projection, and the main body includes that second dashes forward
Rise, second projection is positioned and arrangement is used to engage the shell, to suppress the second container relative to the shell
Axial translation.
13. drug delivery products according to claim 12, wherein first projection is adjacent with first container
First position engage the shell, and second projection is engaged in the second position adjacent with the second container
The shell.
14. drug delivery products according to claim 12, wherein the first and second engagements include described first and second
Projection, the first and second holes that first and second projection is each passed through the shell extend.
15. drug delivery products according to claim 14, wherein exist it is following at least one：I () is described
First hole is that one of in radially spaced multiple first holes of the shell, or (ii) described second hole is around described outer
One of in radially spaced multiple second holes of shell.
16. drug delivery products according to claim 14, wherein extend through first and second hole described the
One and second projection further to suppress the shell in rotary moving relative to the main body.
17. drug delivery products according to claim 12, wherein first and second container is by shifting suit group
Part is contacted, and the transfer suit component includes the port that can be contacted by user, and the main body includes being positioned and arranging use
To engage the well shape portion of the port, or including clogging the stopper of the port, so as to suppress the axial movement of the shell.
18. drug delivery products according to claim 11, wherein the medicine reconstitution component passes through described at least one
It is in rotary moving relative to the main body that the engagement of projection also suppresses the shell.
19. drug delivery products according to claim 11, wherein the medicine reconstitution component passes through described at least one
The engagement of projection also suppresses axial movement of the shell relative to the main body.
A kind of 20. methods of packaged pharmaceuticals reconstitution component, including：
The packaging with removable cover and main body is provided, the main body is configured to accommodate the medicine reconstitution component, institute
Stating packaging includes at least one projection extended from the main body；
The medicine reconstitution component is provided, having the medicine reconstitution component includes the shell at least one hole, and by least
The container in the shell is partially placed at, wherein in the neck portion of the container and the hole of the shell at least
One hole alignment；
By medicine reconstitution component assembling in the main body of the packaging, so as to the main body described at least one dashes forward
Rise through the shell at least one described in hole extend, wherein orientation of the medicine reconstitution component in the packaging is limited
It is formed on the orientation of predetermined quantity；With
Using the removable cover, the medicine reconstitution component is sealed in the main body of the packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710063621.8A CN106880494B (en) | 2012-02-22 | 2012-02-22 | Packaging assembly for preventing premature activation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201280070539.3A CN104136344B (en) | 2012-02-22 | 2012-02-22 | Prevent the package component of premature activation |
| PCT/US2012/026127 WO2013126055A1 (en) | 2012-02-22 | 2012-02-22 | Packaging assembly to prevent premature activation |
| CN201710063621.8A CN106880494B (en) | 2012-02-22 | 2012-02-22 | Packaging assembly for preventing premature activation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280070539.3A Division CN104136344B (en) | 2012-02-22 | 2012-02-22 | Prevent the package component of premature activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106880494A true CN106880494A (en) | 2017-06-23 |
| CN106880494B CN106880494B (en) | 2019-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710063621.8A Active CN106880494B (en) | 2012-02-22 | 2012-02-22 | Packaging assembly for preventing premature activation |
| CN201280070539.3A Active CN104136344B (en) | 2012-02-22 | 2012-02-22 | Prevent the package component of premature activation |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280070539.3A Active CN104136344B (en) | 2012-02-22 | 2012-02-22 | Prevent the package component of premature activation |
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|---|---|
| EP (1) | EP2817240B1 (en) |
| JP (1) | JP6014868B2 (en) |
| KR (1) | KR101763459B1 (en) |
| CN (2) | CN106880494B (en) |
| AU (1) | AU2012370463B2 (en) |
| BR (1) | BR112014020595B1 (en) |
| CA (1) | CA2865002C (en) |
| ES (1) | ES2576294T3 (en) |
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| HU (1) | HUE029693T2 (en) |
| PL (1) | PL2817240T3 (en) |
| PT (1) | PT2817240E (en) |
| SG (1) | SG11201405126XA (en) |
| WO (1) | WO2013126055A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012370463B2 (en) * | 2012-02-22 | 2015-09-17 | Takeda Pharmaceutical Company Limited | Packaging assembly to prevent premature activation |
| IT201700053553A1 (en) * | 2017-05-17 | 2018-11-17 | Cryovac Inc | PACKAGED PRODUCT, EQUIPMENT AND PACKAGING METHOD FOR THE REALIZATION OF SUCH A PRODUCT PACKAGED |
| CN107456627B (en) * | 2017-08-03 | 2020-08-28 | 东莞市迈聚医疗科技有限公司 | Realize safe full-automatic piercing depth of plastics blood bag and virus inactivation bag |
| EP3860549A1 (en) | 2018-10-03 | 2021-08-11 | Takeda Pharmaceutical Company Limited | Packaging for multiple containers |
| EP4209235A1 (en) * | 2020-10-06 | 2023-07-12 | Eoflow Co., Ltd. | Liquid medicine injection device |
| USD983997S1 (en) | 2021-07-22 | 2023-04-18 | Kairish Innotech Private Limited | Tray for a vial and vial adapter |
| USD1011552S1 (en) | 2021-09-09 | 2024-01-16 | KAIRISH INNOTECH Private Ltd. | Tray assembly for a vial and vial adapter |
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| CN1115565A (en) * | 1993-10-06 | 1996-01-24 | 派·丹尼尔 | Cartridge for applying medicament to an eye |
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- 2012-02-22 EP EP12709729.3A patent/EP2817240B1/en active Active
- 2012-02-22 WO PCT/US2012/026127 patent/WO2013126055A1/en active Application Filing
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- 2012-02-22 KR KR1020147025927A patent/KR101763459B1/en active IP Right Grant
- 2012-02-22 JP JP2014558715A patent/JP6014868B2/en active Active
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- 2012-02-22 ES ES12709729.3T patent/ES2576294T3/en active Active
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- 2012-02-22 CN CN201280070539.3A patent/CN104136344B/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2576294T3 (en) | 2016-07-06 |
| KR101763459B1 (en) | 2017-07-31 |
| JP2015509401A (en) | 2015-03-30 |
| HUE029693T2 (en) | 2017-03-28 |
| KR20140125875A (en) | 2014-10-29 |
| CN104136344B (en) | 2017-03-08 |
| CN106880494B (en) | 2019-12-31 |
| AU2012370463B2 (en) | 2015-09-17 |
| WO2013126055A1 (en) | 2013-08-29 |
| CA2865002A1 (en) | 2013-08-29 |
| PL2817240T3 (en) | 2016-12-30 |
| PT2817240E (en) | 2016-06-20 |
| EP2817240B1 (en) | 2016-04-20 |
| BR112014020595B1 (en) | 2021-01-12 |
| CN104136344A (en) | 2014-11-05 |
| JP6014868B2 (en) | 2016-10-26 |
| AU2012370463A1 (en) | 2014-09-18 |
| SG11201405126XA (en) | 2014-10-30 |
| HK1205728A1 (en) | 2015-12-24 |
| CA2865002C (en) | 2017-04-04 |
| BR112014020595A8 (en) | 2020-05-12 |
| EP2817240A1 (en) | 2014-12-31 |
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