CN106872272A - A kind of dissection of aorta diaphragm organization mechanicses attribute determines devices and methods therefor - Google Patents
A kind of dissection of aorta diaphragm organization mechanicses attribute determines devices and methods therefor Download PDFInfo
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- CN106872272A CN106872272A CN201710099417.1A CN201710099417A CN106872272A CN 106872272 A CN106872272 A CN 106872272A CN 201710099417 A CN201710099417 A CN 201710099417A CN 106872272 A CN106872272 A CN 106872272A
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- 210000000709 aorta Anatomy 0.000 title claims abstract description 34
- 238000002224 dissection Methods 0.000 title claims abstract description 28
- 230000008520 organization Effects 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000012360 testing method Methods 0.000 claims abstract description 25
- 238000002474 experimental method Methods 0.000 claims abstract description 19
- 239000000758 substrate Substances 0.000 claims abstract description 17
- 238000006073 displacement reaction Methods 0.000 claims abstract description 15
- 230000001105 regulatory effect Effects 0.000 claims description 9
- 239000002504 physiological saline solution Substances 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000003709 image segmentation Methods 0.000 claims description 3
- 238000005457 optimization Methods 0.000 claims description 3
- 238000005057 refrigeration Methods 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 206010011968 Decreased immune responsiveness Diseases 0.000 claims 1
- 239000011229 interlayer Substances 0.000 abstract description 13
- 238000001356 surgical procedure Methods 0.000 abstract description 5
- 238000004393 prognosis Methods 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 12
- 238000011161 development Methods 0.000 description 8
- 230000018109 developmental process Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 210000004872 soft tissue Anatomy 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000002792 vascular Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 208000032594 Vascular Remodeling Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
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- 238000005259 measurement Methods 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
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- 238000009864 tensile test Methods 0.000 description 2
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- 208000002251 Dissecting Aneurysm Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 206010002895 aortic dissection Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0016—Tensile or compressive
- G01N2203/0017—Tensile
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0069—Fatigue, creep, strain-stress relations or elastic constants
- G01N2203/0075—Strain-stress relations or elastic constants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/022—Environment of the test
- G01N2203/0222—Temperature
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/026—Specifications of the specimen
- G01N2203/0262—Shape of the specimen
- G01N2203/0278—Thin specimens
- G01N2203/0282—Two dimensional, e.g. tapes, webs, sheets, strips, disks or membranes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/06—Indicating or recording means; Sensing means
- G01N2203/0641—Indicating or recording means; Sensing means using optical, X-ray, ultraviolet, infrared or similar detectors
- G01N2203/0647—Image analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/06—Indicating or recording means; Sensing means
- G01N2203/067—Parameter measured for estimating the property
- G01N2203/0682—Spatial dimension, e.g. length, area, angle
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Abstract
Devices and methods therefor is determined the invention discloses a kind of dissection of aorta diaphragm organization mechanicses attribute, including first substrate and second substrate, the upper end left side of first substrate is provided with vertical rod, vertical rod is connected with the first cross bar, the right-hand member of the first cross bar is connected with the second cross bar, second cross bar is connected with high-speed motion picture camera, the upper end left side of second substrate is provided with the first support frame, thermostatic platform is provided with first support frame, the upper end of thermostatic platform is provided with experiment plate, the right side of second substrate is provided with the second support frame, the upper end of the second support frame is provided with displacement control unit, the left side of thermostatic platform is provided with load test unit.The diaphragm tissue tensile strength that the present invention is obtained can be used to predict that aorta pectoralis EVAR medium-height trestle produces the possibility damaged to diaphragm tissue, trigger the complication such as new interlayer so as to reduce support, operation safety is improved, and improves the accuracy of dissection of aorta surgery planning and prognosis related algorithm.
Description
Technical field
Determined the present invention relates to sustainer determination techniques field, especially a kind of dissection of aorta diaphragm organization mechanicses attribute
Devices and methods therefor.
Background technology
Dissection of aorta is the high-risk arotic disease of a class.Vascular remodeling effect and master after its Crack cause and treatment
Hemodynamic characteristics are directly related in artery local organization mechanical attribute and sustainer.Clinically for the diagnosis of the disease
The Morphologic Parameters that medical image is provided, such as aorta diameter, false chamber diameter are relied primarily on the judgement to therapeutic effect.
Morphologic Parameters can reflect morbid state, but lack the predictive assessment to disease development.With reference to Hemodynamics, blood flow and blood
The Computational Mechanics analysis of the wind-structure interaction, Vascular remodeling model of tube wall can aid in the prediction of disease development, for referring to
Leading follow-up and formulating operation plan has important value.But the accuracy of the predictive analysis of Computational Mechanics largely depends on
In the accuracy of cast material attribute assignment and people to the understanding of vascular tissue's strength of materials, accordingly, it would be desirable to a kind of be adapted to
In the method and apparatus of measurement dissection of aorta diaphragm organization mechanicses performance, for correlative study provides material properties and intensity ginseng
Number.
Can be mainly used in two aspects for the dynamics measurement of dissection of aorta diaphragm tissue：1. couple Type B interlayer row chest master
The preoperative planning of artery EVAR；2. the prediction pair postoperative residue vacation chamber development.In the preoperative in terms of planning, Type B interlayer refers to
Main tearing port is located at the interlayer of arch of aorta distal end, and its primary treatments is aorta pectoralis EVAR, i.e., by inserting
Stent (stent-graft) is realized being reinvented to the closure of main tearing port and to the support true cavity region of covering.But at this
In the practical application of method, some patients can trigger new tearing port because support is inserted.By automated graphics and Three-dimensional Gravity
Build and virtual bracket Fast simulating method, we can obtain the interaction result with vascular wall after support discharges, that is, obtain
Obtain the true chamber of blood vessel and reinvent effect.The true chamber of blood vessel when not discharging support is contrasted with this, can be calculated produced by interlayer diaphragm tissue
Displacement, and combine Experiments of Machanics to the measure of the strength of materials, then can determine whether whether this deformation can produce diaphragm disorganization, i.e.,
Prediction support triggers the possibility of new breach.On the other hand, after surgery in the development prediction in remaining vacation chamber, the interlayer film for being determined
Piece organization mechanicses attribute can be used for fluid and structural simulation, that is, analyze the interaction of blood flow and vascular wall.This calculates analysis and combines
Tissue reconstruction model can obtain Form Development of the interlayer diaphragm under pulsatile blood flow promotion, so that in helping doctor near after surgery
The remnants vacations chamber development of phase predicting long-term, it is determined that the high risk patient that need to closely pay close attention to, and intervening measure is taken in due course,
Improve the security and validity for aortic dissection.
Prior art one, uniaxial tensile test：Test sample is cut into strip, between being placed in fixture, sample is carried out
The data of stretching, record displacement and power, and by the measure to strip test article geometry, calculate load-deformation curve.Pin
To different samples, reasonable selection strain energy equation, by load-deformation curve, this structure side of fitting description sample mechanical attribute
Each parameter in journey, obtains sample mechanical attribute.Record load-deformation curve peak value, obtains test sample tensile strength.
The major defect of prior art one is that, for soft tissues such as vascular walls, the fixture of stretching device is in clamping process
In can have certain influence on soft tissue, clamping tension can destroy sample, and clamping pine can produce landing, at present, not yet there is pin
To the jig Design suitable for uniaxial tensile test of dissection of aorta diaphragm；Determined for soft tissue, sample is near fixture
Stronger boundary effect is had, and deformation is larger, being calculated with displacement by sample original geometry form and the load for being determined should
Power and strain can have larger error with the stress of authentic sample, strain.Needs mark point on soft tissue sample, and record drawing
Sample image during stretching.By image procossing, it is determined that leaning on paracentral soft tissue sample displacement, then ess-strain is carried out
Treatment, can just obtain the data result determined suitable for soft tissue mechanics attribute.
Test sample is cut into square by prior art two, biaxial tension-compression strength, and (fixture is generally between being placed in fixture
Hook type), two synchro-draws of orthogonal direction are carried out to sample, the displacement of both direction and the data of power are recorded, and by right
The measure of square test article geometry, calculates load-deformation curve, and for different samples, reasonable selection constitutive equation is led to
Overstress-strain curve, is fitted the constitutive equation parameter of all directions, obtains sample anisotropy mechanical attribute.
The major defect of prior art two is that the mechanics parameter that biaxial tension-compression strength is applied to anisotropic material is surveyed
It is fixed, but material damage intensity can not be typically provided, because its hook type fixture easily causes sample stress raisers, and sample four
Individual angle point lacks constraint, and the stress-strain diagram scope that biaxial tension-compression strength is provided is smaller, and this test method is applied to small change
Shape is determined, and for large deformation even sample broke, this experiment has limitation.
Therefore, for above mentioned problem be necessary to propose a kind of dissection of aorta diaphragm organization mechanicses attribute determine device and its
Method.
The content of the invention
For above-mentioned the deficiencies in the prior art, dissection of aorta hand is improved it is an object of the invention to provide one kind
Art is planned and the dissection of aorta diaphragm organization mechanicses attribute of prognosis determines devices and methods therefor.
A kind of dissection of aorta diaphragm organization mechanicses attribute determines device, including first substrate and second substrate, and described the
The upper end left side of one substrate is provided with vertical rod, and the vertical rod is connected with the first cross bar, and the right-hand member of first cross bar is connected with
Second cross bar, second cross bar is connected with high-speed motion picture camera, and the left side of the upper end of the second substrate is provided with first
Support frame frame, is provided with thermostatic platform in first support frame, the upper end of the thermostatic platform is provided with experiment plate, second base
The right side of plate is provided with the second support frame, and the upper end of second support frame is provided with displacement control unit.
Preferably, the left side of the thermostatic platform is provided with load test unit, and the load test unit passes through first
Link tube is connected with the first fixture, and first fixture is arranged in experiment plate.
Preferably, the displacement control unit is connected with the second fixture by the second connecting tube, and second fixture is set
In experiment plate.
Preferably, first fixture and the second fixture have spring regulating device, can be adjusted according to thickness of sample.
Preferably, the vertical rod is provided with the first regulating block, first cross bar and the second horizontal stroke with the first cross bar junction
Bar junction is provided with the second regulating block.
Preferably, sample is connected between first fixture and the second fixture, several is provided with the sample
Every the mark point of distribution.
A kind of dissection of aorta diaphragm organization mechanicses attribute assay method, its method and step is：(1) dissection of aorta is obtained
Diaphragm sample, mark sample direction, adds antifreezing agent, is placed in -80 degree refrigerations；Risen again (37 to sample before being measured
Degree), cut growth 10-20mm, the strip test article for being about 1-2mm wide, record sample mean thickness (T0), it is placed in 37 degree of constant temperature
Physiological saline in；
(2) between sample is placed in into test device fixture, by alignment jig spring knob, it is ensured that fixture gap is about sample
0.3 times of average thickness；A treatment is marked to diaphragm sample upper surface, as shown in Fig. 2 marking a mark every 2.5mm
Note point；
(3) thermostatic platform and experiment plate are risen, sample is totally submerged in 37 degree of experiment plates of physiological saline are filled, started
Tension test, the fast camera of experimental rig synchronizes shooting, the picture of power, displacement and synchronization in storage drawing process
Data；
(4) image information to each sampled point is processed, and the two of sample center are pointed to based on region-growing method
Individual adjacent marker point carries out image segmentation, and its edge is smoothed, and two mark points of calculating are on sample draw direction
Distance (L between distance (being designated as L) between central point, with the central point of two mark points when stretching initial0) compare, obtain each sampling
Elongation (λ=the L/L of point0)；
(5) by stretching the image of initial time, the initial mean breadth (W of sample is calculated0), obtained with reference in step 1
The average thickness T for obtaining0, and the load force value (F) that each sampled point is obtained, by incompressibility, drawing can be calculated
Stretch stress
(6) tensile stress maximum, the as tensile strength (σ of diaphragm sample are extractedS)；
(7) each bar-shaped sample can obtain one group of elongation (λ after the testi) and tensile stress numerical value (σi), it is
Acquisition can be used to calculate the representative elongation-stress curve of constitutive equation parameter, and this patent uses Energy distribution algorithm, that is, counts
Calculate each group of elongation and the elasticity corresponding to tensile stress can (W),To corresponding to energy datum
Number range carry out N deciles (testing bar number>N values are optional 100) when 100, when the interval corresponding sample number of each energy>5
During bar, the energy interval efficiency；Remove invalid energy interval, re-start energy interval N deciles, screening effective energy is interval,
Circulate operation is to whole energy interval efficiencies；Obtain through the average elongation of energy and tensile stress numerical value (λkAnd σk, k=
1,2,3..N)；
(8) Cauchy principal stress (σ in the stretching direction is calculated selected strain energy equation1), be expressed as it with
Constitutive equation parameter and elongation are the expression-form of variable, withFor target carries out parameter optimization conjunction, obtain
Obtain relative errorConstitutive equation parameter within 8%, so that it is determined that diaphragm organization mechanicses belong to
Property.
Due to using above-mentioned technical proposal, the diaphragm tissue tensile strength that the present invention is obtained to can be used to predict aorta pectoralis
EVAR medium-height trestle produces the possibility damaged to diaphragm tissue, so as to reduce the complication that support triggers new interlayer, carries
Operation safety high；And the diaphragm organization mechanicses attribute for being obtained can be used to set up the constitutive equation of diaphragm tissue, by this equation
The development of the interlayer of patient can be predicted in being calculated for tissue reconstruction, thus help doctor screen interlayer can it is expansible,
The patient for paying close attention to is needed, the validity of Follow-up After is improved, the present invention will be to improving dissection of aorta surgery planning and disease
The accuracy and practicality of feelings prediction related algorithm are significant.
Brief description of the drawings
Fig. 1 is apparatus structure schematic diagram of the invention；
Fig. 2 is the fixture clamping sample view of embodiments of the invention.
Specific embodiment
Embodiments of the invention are described in detail below in conjunction with accompanying drawing, but the present invention can be defined by the claims
Multitude of different ways with covering is implemented.
Such as Fig. 1 is simultaneously combined shown in Fig. 2, and a kind of dissection of aorta diaphragm organization mechanicses attribute determines device, including the first base
Plate 7 and second substrate 8, the upper end left side of the first substrate 7 are provided with vertical rod 13, and the vertical rod 13 is connected with the first cross bar
15, the right-hand member of first cross bar 15 is connected with the second cross bar 19, and second cross bar 19 is connected with high-speed motion picture camera 6, described
The left side of the upper end of second substrate 8 is provided with the first support frame 9, and thermostatic platform 4 is provided with first support frame 9,
The liftable of thermostatic platform 4, the upper end of the thermostatic platform 4 is provided with experiment plate 3, and the right side of the second substrate 8 is provided with second
Support frame 10, the upper end of second support frame 10 is provided with displacement control unit 5, and displacement control unit 5 can be carried out
It is slidably connected.
Further, the left side of the thermostatic platform 4 is provided with load test unit 1, and the load test unit 1 passes through
First connecting rod pipe 11 is connected with the first fixture 2, and first fixture 2 is arranged in experiment plate (when thermostatic platform rises), institute's rheme
Move control unit 5 and second fixture 21 is connected with by the second connecting tube 12, second fixture 21 is arranged in experiment plate 3 (permanent
When warm platform rises), the first fixture 2 and the second fixture 21 can carry out grip force regulation by spring regulating device；First folder
Tool has spring regulating device with the second fixture, can be adjusted according to thickness of sample.
Further, the junction of 13 and first cross bar of the vertical rod 15 is provided with the first regulating block 14, first cross bar
15 and the junction of the second cross bar 19 be provided with the second regulating block 19, be connected with examination between the fixture 21 of first fixture 2 and second
Sample 17, is provided with several mark points 18 being spaced apart on the sample 19.
A kind of dissection of aorta diaphragm organization mechanicses attribute assay method, its method and step is：(1) dissection of aorta is obtained
Diaphragm sample, mark sample direction, adds antifreezing agent, is placed in -80 degree refrigerations；Risen again (37 to sample before being measured
Degree), cut growth 10-20mm, the strip test article for being about 1-2mm wide, record sample mean thickness (T0), it is placed in 37 degree of constant temperature
Physiological saline in；(2) between sample is placed in into test device fixture, by alignment jig spring knob, it is ensured that fixture gap is about
It is 0.3 times of sample mean thickness；A treatment is marked to diaphragm sample upper surface, as shown in Fig. 2 every 2.5mm marks
One mark point；(3) thermostatic platform and experiment plate are risen, sample is totally submerged in 37 degree of experiment plates of physiological saline are filled,
Start tension test, the fast camera of experimental rig synchronizes shooting, the power, displacement and synchronization in storage drawing process
Image data；(4) image information to each sampled point is processed, and the two of sample center are pointed to based on region-growing method
Individual adjacent marker point carries out image segmentation, and its edge is smoothed, and two mark points of calculating are on sample draw direction
Distance (L between distance (being designated as L) between central point, with the central point of two mark points when stretching initial0) compare, obtain each sampling
Elongation (λ=the L/L of point0)；
(5) by stretching the image of initial time, the initial mean breadth (W of sample is calculated0), obtained with reference in step 1
The average thickness T for obtaining0, and the load force value (F) that each sampled point is obtained, by incompressibility, drawing can be calculated
Stretch stress(6) tensile stress maximum, the as tensile strength (σ of diaphragm sample are extractedS)；(7) each
Shape sample can obtain one group of elongation (λ after the testi) and tensile stress numerical value (σi), can be used to calculate this structure to obtain
Representative elongation-the stress curve of equation parameter, this patent uses Energy distribution algorithm, that is, calculate each group of elongation and drawing
Elasticity energy (W) corresponding to stress is stretched,N deciles are carried out to the number range corresponding to energy datum
(testing bar number>N values are optional 100) when 100, when the interval corresponding sample number of each energy>At 5, the energy interval efficiency；
Remove invalid energy interval, re-start energy interval N deciles, screening effective energy is interval, circulate operation to whole energy ranges
Between effectively untill；Obtain through the average elongation of energy and tensile stress numerical value (λkAnd σk, k=1,2,3..N)；(8) to selected
Fixed strain energy equation calculates Cauchy's principal stress (σ in the stretching direction1), it is expressed as it with constitutive equation parameter and extension
Rate is the expression-form of variable, withFor target carries out parameter optimization conjunction, relative error is obtainedConstitutive equation parameter within 8%, so that it is determined that diaphragm organization mechanicses attribute.
The diaphragm tissue tensile strength that the present invention is obtained can be used to predict aorta pectoralis EVAR medium-height trestle to film
Piece tissue produces the possibility damaged, so as to reduce the complication that support triggers new interlayer, improves operation safety；And obtained
Diaphragm organization mechanicses attribute can be used to set up the constitutive equation of diaphragm tissue, by this equation be used for tissue reconstruction calculate in can be right
The interlayer development of patient is predicted, so that help doctor to screen interlayer can patient that is expansible, needing close attention, raising
The validity of Follow-up After, the present invention by improve dissection of aorta surgery planning and prognosis related algorithm accuracy and
Practicality is significant.
The preferred embodiments of the present invention are the foregoing is only, the scope of the claims of the invention, every utilization is not thereby limited
Equivalent structure or equivalent flow conversion that description of the invention and accompanying drawing content are made, or directly or indirectly it is used in other correlations
Technical field, be included within the scope of the present invention.
Claims (7)
1. a kind of dissection of aorta diaphragm organization mechanicses attribute determines device, it is characterised in that：Including first substrate and the second base
Plate, the upper end left side of the first substrate is provided with vertical rod, and the vertical rod is connected with the first cross bar, the right side of first cross bar
End is connected with the second cross bar, and second cross bar is connected with high-speed motion picture camera, and the upper end left side of the second substrate is provided with
First support frame, is provided with thermostatic platform in first support frame, the upper end of the thermostatic platform is provided with experiment plate, described
The right side of second substrate is provided with the second support frame, and the upper end of second support frame is provided with displacement control unit.
2. a kind of dissection of aorta diaphragm organization mechanicses attribute as claimed in claim 1 determines device, it is characterised in that：It is described
The left side of thermostatic platform is provided with load test unit, and the load test unit is connected with the first folder by first connecting rod pipe
Tool, first fixture is arranged in experiment plate.
3. a kind of dissection of aorta diaphragm organization mechanicses attribute as claimed in claim 1 determines device, it is characterised in that：It is described
Displacement control unit is connected with the second fixture by the second connecting tube, and second fixture is arranged in experiment plate.
4. a kind of dissection of aorta diaphragm organization mechanicses attribute as claimed in claim 2 determines device, it is characterised in that：It is described
First fixture and the second fixture have spring regulating device, can be adjusted according to thickness of sample.
5. a kind of dissection of aorta diaphragm organization mechanicses attribute as claimed in claim 1 determines device, it is characterised in that：It is described
Vertical rod is provided with the first regulating block with the first cross bar junction, and first cross bar and the second cross bar junction are provided with the second tune
Locking nub.
6. a kind of dissection of aorta diaphragm organization mechanicses attribute as claimed in claim 2 determines device, it is characterised in that：It is described
Sample is connected between first fixture and the second fixture, several mark points being spaced apart are provided with the sample.
7. a kind of dissection of aorta diaphragm organization mechanicses attribute assay method, it is characterised in that：Its method and step is：(1) obtain
Dissection of aorta diaphragm sample, mark sample direction, adds antifreezing agent, is placed in -80 degree refrigerations；To sample before being measured
Risen again, cut growth 10-20mm, the strip test article for being about 1-2mm wide, record sample mean thickness (T0), it is placed in perseverance
In the physiological saline of 37 degree of temperature；
(2) between sample is placed in into test device fixture, by alignment jig spring knob, it is ensured that fixture gap is about sample mean
0.3 times of thickness；A treatment is marked to diaphragm sample upper surface, a mark point is marked every 2.5mm；
(3) thermostatic platform and experiment plate are risen, sample is totally submerged in 37 degree of experiment plates of physiological saline are filled, start stretching
Experiment, the fast camera of experimental rig synchronizes shooting, the picture number of power, displacement and synchronization in storage drawing process
According to；
(4) image information to each sampled point is processed, and two phases at sample center are pointed to based on region-growing method
Adjacent mark point carries out image segmentation, and its edge is smoothed, and calculates center of two mark points on sample draw direction
Distance (L between distance (being designated as L) between point, with the central point of two mark points when stretching initial0) compare, obtain each sampled point
Elongation (λ=L/L0)；
(5) by stretching the image of initial time, the initial mean breadth (W of sample is calculated0), with reference to flat obtained in step 1
Equal thickness T0, and the load force value (F) that each sampled point is obtained, by incompressibility, tensile stress can be calculated
(6) tensile stress maximum, the as tensile strength (σ of diaphragm sample are extractedS)；
(7) each bar-shaped sample can obtain one group of elongation (λ after the testi) and tensile stress numerical value (σi), to obtain
Can be used to calculate the representative elongation-stress curve of constitutive equation parameter, this patent uses Energy distribution algorithm, that is, calculate every
Elasticity energy (W) corresponding to one group of elongation and tensile stress,To the number corresponding to energy datum
Value scope carries out N deciles, when the interval corresponding sample number of each energy>At 5, the energy interval efficiency；Removal anergy
Amount is interval, re-starts energy interval N deciles, and screening effective energy is interval, and circulate operation is to whole energy interval efficiencies；
Obtain through the average elongation of energy and tensile stress numerical value (λkAnd σk, k=1,2,3..N)；
(8) Cauchy principal stress (σ in the stretching direction is calculated selected strain energy equation1), it is expressed as it with this structure side
Journey parameter and elongation are the expression-form of variable, withFor target carries out parameter optimization conjunction, obtain relative
ErrorConstitutive equation parameter within 8%, so that it is determined that diaphragm organization mechanicses attribute.
Priority Applications (1)
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