CN106865804B - Clean production method of Zhongshengmycin mother medicine - Google Patents
Clean production method of Zhongshengmycin mother medicine Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
- C02F1/442—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by nanofiltration
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/001—Processes for the treatment of water whereby the filtration technique is of importance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Abstract
The invention discloses a clean production method of zhongshengmycin mother drug, which comprises the steps of putting a fermentation tank in the production process of the zhongshengmycin mother drug into tank washing water, spraying tower washing water, water foam dedusting wastewater in the spraying process, a ceramic membrane system, membrane system cleaning washing water of a nanofiltration membrane system, permeate filtered by the nanofiltration membrane system and the like to be recycled and used as ingredient water of a fermentation medium or a fermentation tank supplement medium of a zhongshengmycin fermentation tank, so that the content of high-concentration COD and NH in the production process is reduced3And N wastewater is discharged, so that energy conservation, emission reduction and clean production are realized. The method does not reduce the fermentation production level of the zhongshengmycin and the quality of the zhongshengmycin mother medicine product, reduces the loss of the product, reduces the use of water resources, simultaneously reduces the labor intensity of workers, saves manpower and material resources, improves the environment-friendly compatibility of the zhongshengmycin mother medicine production, and has good economic and social benefits.
Description
Technical Field
The invention relates to production of biopesticide, in particular to a clean production method of zhongshengmycin mother medicine.
Background
According to the statistics of the Food and Agriculture Organization (FAO) of the United nations, in the agriculture and forestry production process all over the world; the annual loss caused by diseases, insect pests and weeds is more than one third. Approximately 300 million chemical pesticide intoxication events occur worldwide each year. In developing countries, collective poisoning events caused by food contamination with pesticides occur around 1650 worldwide each year. Therefore, the vigorous development of biopesticides with safety, low toxicity and non-toxicity, low and no accumulation, and no environmental pollution has become an inevitable trend and global consensus. The Zhongshengmycin is a new oneThe application of the agricultural antibiotic biopesticide belongs to the category of bactericides and is used for preventing and treating crop diseases. The producing strain is obtained by separating from soil in Hainan island of China and named as Hainanensis n. As an agricultural antibacterial biological pesticide, the compound has strong inhibiting or killing effects on gram-positive bacteria, gram-negative bacteria and filamentous fungi. Has good control effect on rice bacterial leaf blight, cabbage soft rot, apple ring spot, apple leaf spot and the like. But is safe to human and livestock with low toxicity and is compatible and friendly to the environment. Zhongshengmycin (chemical name: 1-N glycoside chain internal fixation-2-amino-L-lysine-2 deoxy gulosamine; molecular formula: C)19H34O8N8(ii) a Molecular weight: 502.0) has the characteristics of high efficiency, low toxicity, low accumulation and no residue, and finally causes the death of bacteria by inhibiting the generation of peptide bonds of pathogenic bacteria proteins; the fungi can inhibit the growth of hyphae and the germination of spores, and the fungal diseases can be prevented and treated; is a necessary medicine for pollution-free fruit trees and vegetable production bases. Can be widely used for preventing and treating rice bacterial leaf blight, apple ring spot, cabbage soft rot, etc. Therefore, a clean production method of the zhongshengmycin mother drug is developed, and the high-concentration COD and NH in the production process are reduced3The discharge of N waste water, the labor intensity of staff is reduced, the cyclic utilization is realized, the energy is saved, the consumption is reduced, the environment-friendly compatibility of the production of the zhongshengmycin mother drug is improved, and the economic and social benefits are good.
The zhongshengmycin mother medicine is a product obtained by taking a Hainan variety of streptomyces lavendulae as a producing bacterium and taking soybean cake powder, corn starch, corn flour, glucose, calcium carbonate, sodium chloride, ammonium chloride, magnesium sulfate, glutamic acid, arginine, caustic soda flakes and the like as main raw materials through fermentation culture, extraction and drying.
The main process method for producing the zhongshengmycin mother drug at present comprises the following steps: shaking the seeds of the zhongshengmycin producing bacteria to culture → inoculating to a seed tank to perform enlarged culture → inoculating to a fermentation tank to perform fermentation culture to produce zhongshengmycin → placing fermentation liquor in the tank → performing liquid-solid separation on the fermentation liquor in the tank through a ceramic membrane system → concentrating the obtained filtrate through a nanofiltration membrane system → uniformly mixing the obtained concentrated solution and the solid matters separated from the ceramic membrane system according to a certain proportion and performing spray drying to obtain the zhongshengmycin mother drug.
In the prior zhongshengmycin mother drug production process, tank placing and tank washing water of a fermentation tank, spray tower washing water, water foam dedusting wastewater in the spraying process, membrane system cleaning and washing water of a ceramic membrane system and a nanofiltration membrane system, filtrate of the nanofiltration membrane system and the like are directly discharged into a sewage treatment station of a company for centralized treatment.
The current process produces 1 batch of zhongshengmycin per day and produces wastewater with main components and average pollutant content:
production of 1 batch per day 360 days each year, 9000m of wastewater production, 53183kg of COD contaminants production, and NH production3203kg of N contaminants, with 2365kg of zhongshengmycin being lost.
The prior production process has the following defects:
1. the fermentation tank in the production process of the zhongshengmycin mother drug is placed with tank washing water, spray tower washing water, water foam dedusting wastewater in the spraying process, membrane system cleaning washing wastewater of a ceramic membrane system and a nanofiltration membrane system, permeate of a nanofiltration membrane system, and the like, which contain high-concentration COD and NH3the-N mass production wastewater is directly discharged into a company sewage treatment station for treatment, the pressure of biochemical treatment of the company sewage treatment station is increased, and meanwhile, the loss and waste of effective components of zhongshengmycin contained in the tank-placing and tank-washing water of a fermentation tank and the tower-washing water of a spray tower are caused.
2. Due to the treatment of a large amount of high-concentration COD and NH3The N-waste water greatly increases the energy consumption and the cost of sewage treatment, increases the pressure of environment-friendly compatibility in the production of the zhongshengmycin mother drug, and increases the labor intensity of workers.
Disclosure of Invention
The invention aims to solve the technical problem of providing a clean production method of a zhongshengmycin mother drug, which can greatly reduce the high content of the zhongshengmycin in the production process of the zhongshengmycin mother drugConcentration of COD and NH3-discharge of N waste liquid; the labor intensity of staff is reduced; and the method can also save water resources, reduce the sewage treatment cost, reduce the loss and waste of the effective components of the zhongshengmycin, and realize energy conservation, emission reduction and clean production.
In order to solve the problems, the technical solution of the invention is as follows:
a clean production method of zhongshengmycin mother medicine comprises the steps of recycling zhongshengmycin fermentation tank washing water, spray tower washing water, water foam dedusting wastewater in the spraying process, a ceramic membrane system, membrane system cleaning water of a nanofiltration membrane system, filtrate of the nanofiltration membrane system and the like in the production process of the zhongshengmycin mother medicine, and reducing the content of high-concentration COD and NH in the production process3And (4) discharging N waste liquid, reducing the use of water resources, and realizing energy conservation, emission reduction and clean production. The method comprises the following technical processes:
1. adding the tank-placing and washing water of the zhongshengmycin fermentation tank into the fermented liquid of the zhongshengmycin tank of the current batch, carrying out liquid-solid separation on the fermented liquid of the zhongshengmycin tank by using a ceramic membrane system, concentrating the obtained filtered liquid of the ceramic membrane system by using a nanofiltration membrane system, obtaining a zhongshengmycin concentrated solution and a filtered permeate of the nanofiltration membrane system, and using the filtered permeate of the nanofiltration membrane system as the ingredient water of the fermentation medium or the supplementary medium of the other batch of zhongshengmycin fermentation tank.
(1) The tank-placing and tank-washing water of the zhongshengmycin fermentation tank is the tank-washing water after the seed tank is transplanted, the tank-washing water after the material supplementing tank is supplemented, and the tank-washing water after the fermentation tank is placed.
(2) And the filtered permeate of the nanofiltration membrane system is the permeate which permeates the nanofiltration membrane system in the process of concentrating the filtrate of the ceramic membrane system by the nanofiltration membrane system.
2. Adding the washing tower water of the zhongshengmycin spraying tower, the water foam dedusting wastewater in the spraying process, the membrane system cleaning water of the ceramic membrane system and the nanofiltration membrane system into another batch of zhongshengmycin tank fermentation liquor, carrying out liquid-solid separation on the tank fermentation liquor through the ceramic membrane system, concentrating the filtrate of the ceramic membrane system through the nanofiltration membrane system to obtain a concentrated solution and a permeate filtered by the nanofiltration membrane system, and using the permeate filtered by the nanofiltration membrane system as the batching water of the fermentation medium or the supplementary medium of another batch of zhongshengmycin fermentation tanks.
(1) The water in the spray tower is the waste water collected by cleaning and washing the spray tower after the powdery zhongshengmycin mother medicine finished product is obtained by spray drying the zhongshengmycin concentrated solution.
(2) The water foam dedusting wastewater in the spraying process is collected by removing dust from trace dust carried by tail gas of the zhongshengmycin concentrated solution in the spraying drying process by adopting a water foam dedusting process.
(3) The membrane system cleaning water is wastewater which is obtained by cleaning, washing and collecting equipment of the ceramic membrane system and the nanofiltration membrane system after the fermentation liquor is subjected to liquid-solid separation by the ceramic membrane system and concentration by the nanofiltration membrane system.
After adopting the scheme, compared with the prior art, the invention has the following remarkable characteristics:
1. the clean production method of the Zhongshengmycin mother drug reduces the content of high-concentration COD and NH in the production process of the Zhongshengmycin mother drug3And the total amount of N wastewater is discharged, so that the pressure of sewage treatment in the environmental protection station is greatly reduced, and the environment-friendly compatibility of the production of the zhongshengmycin mother drug is improved.
2. The clean production method of the zhongshengmycin mother medicine does not reduce the fermentation production level of zhongshengmycin, does not reduce the quality of the zhongshengmycin mother medicine product, reduces the loss of the product, reduces the use of water resources, and realizes energy conservation, emission reduction and cyclic utilization; meanwhile, the labor intensity of staff is reduced, manpower and material resources are saved, and good economic and social benefits are achieved.
3. According to the characteristics of the Zhongshengmycin mother medicine product, the clean production method of the Zhongshengmycin mother medicine does not need a great deal of technical improvement on the basis of the existing production process and equipment, only a plurality of pumps and pipelines are added to connect the storage tanks for collecting the waste liquid, and the waste liquid is introduced into the culture medium batching tank in the fermentation process, so that the clean production of the Zhongshengmycin mother medicine can be realized.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The present invention will be described in further detail with reference to specific examples.
Example 1
1. Taking the water obtained by placing a fermentation tank in production and washing the tank, the water obtained by washing a spray tower, the water foam dedusting wastewater in the spraying process, the cleaning water obtained by cleaning a ceramic membrane system, a nanofiltration membrane system and the membrane system, and the filtrate obtained by filtering the nanofiltration membrane system as the water for preparing the zhongshengmycin shake-flask fermentation medium, wherein the water for preparing the shake-flask fermentation medium comprises COD (chemical oxygen demand) and NH (NH)3-N etc. in the following:
2. and (4) preparing a fermentation medium by using uncontaminated drinking water as a control, and synchronously performing shake flask fermentation verification.
3. Each group of culture medium was prepared, adjusted to pH 7.3-7.5 with 20% sulfuric acid or 20% sodium hydroxide, distributed in triangular shake flasks with 6 flasks per group by methods known in the art, steam-moist heat sterilized, and inoculated for shake flask culture.
4. The average result of the zhongshengmycin content data of each group of 6-bottle shake flask fermentation culture results is as follows:
example 2
The fermentation tank is filled with tank washing water (the content of the zhongshengmycin is 1.25g/L, COD, and the content is 11820mg/L, NH)3-N content 51.56 mg/L) was prepared in another batch of the fermentation medium of the zhongshengmycin fermenter, pH was adjusted to 7.3-7.5, the prepared medium in the fermenter was sterilized, inoculated, cultured, supplemented, and placed in the fermenter by a method known in the art, and the content of zhongshengmycin in the fermentation broth placed in the fermenter was determined to be 11.12 g/L. The method comprises the following steps of (1) performing liquid-solid separation on a fermentation liquor of a zhongshengmycin tank by a ceramic membrane system → concentrating a filtrate by a nanofiltration membrane system → uniformly mixing the concentrated solution and a solid substance separated by the ceramic membrane system in proportion, and performing spray drying to obtain a zhongshengmycin mother medicine finished product, wherein the quality indexes of the zhongshengmycin mother medicine finished product are as follows:
example 3
Washing with spray tower (Zhongshengmycin content 2.38g/L, COD content 48483mg/L, NH)3-N content 155.21 mg/L) was prepared in another batch of the zhongshengmycin fermentation medium, the pH was adjusted to 7.3-7.5, the prepared medium in the fermenter was sterilized, inoculated, cultured, supplemented, and put in the tank by methods known in the art, and the content of zhongshengmycin in the fermentation broth in the tank was determined to be 10.58 g/L. The method comprises the following steps of (1) performing liquid-solid separation on a fermentation liquor of a zhongshengmycin tank by a ceramic membrane system → concentrating a filtrate by a nanofiltration membrane system → uniformly mixing the concentrated solution and a solid substance separated by the ceramic membrane system in proportion, and performing spray drying to obtain a zhongshengmycin mother medicine finished product, wherein the quality indexes of the zhongshengmycin mother medicine finished product are as follows:
example 4
Filtering with nanofiltration membrane system to obtain filtrate (containing 0.0049g/L, COD of zhongshengmycin and 948mg/L, NH of zhongshengmycin)3-N content 5.56 mg/L) another batch of zhongshengmycin fermentation medium is prepared, the pH is adjusted to 7.3-7.5, the prepared medium in the fermentation tank is sterilized, inoculated, cultured, supplemented and discharged by a method known in the art, and the content of the zhongshengmycin in the discharged fermentation liquid is measured to be 10.86 g/L. The method comprises the following steps of (1) performing liquid-solid separation on a fermentation liquor of a zhongshengmycin tank by a ceramic membrane system → concentrating a filtrate by a nanofiltration membrane system → uniformly mixing the concentrated solution and a solid substance separated by the ceramic membrane system in proportion, and performing spray drying to obtain a zhongshengmycin mother medicine finished product, wherein the quality indexes of the zhongshengmycin mother medicine finished product are as follows:
example 5
Placing 2 adjacent batches of fermentation tanks into tank washing water, spraying tower washing water, water foam dedusting wastewater in the spraying process, membrane system cleaning washing water and permeate liquid filtered by a nanofiltration membrane system to be uniformly mixed (the content of the zhongshengmycin is 0.25g/L, COD, and the content is 5500mg/L, NH3-N, and the content is 18.25 mg/L), preparing another batch of zhongshengmycin fermentation culture medium, adjusting the pH to 7.3-7.5, carrying out disinfection and sterilization, inoculation, culture, feeding and tank placing on the prepared culture medium in the fermentation tanks by a method known in the industry, and measuring the content of the zhongshengmycin in fermentation liquid in the tank to be 11.03 g/L. The method comprises the following steps of (1) performing liquid-solid separation on a fermentation liquor of a zhongshengmycin tank by a ceramic membrane system → concentrating a filtrate by a nanofiltration membrane system → uniformly mixing the concentrated solution and a solid substance separated by the ceramic membrane system in proportion, and performing spray drying to obtain a zhongshengmycin mother medicine finished product, wherein the quality indexes of the zhongshengmycin mother medicine finished product are as follows:
example 6
Preparing zhongshengmycin fermentation culture medium by drinking water, and sterilizing, inoculating and culturing the culture medium in the prepared fermentation tank with the pH value adjusted to 7.3-7.5 by a method known in the industry; filtering the permeate with another nanofiltration membrane system (containing 0.0051g/L, COD-958 mg/L, NH of zhongshengmycin)3-N content 5.68 mg/L) was prepared the batch of zhongshengmycin fermenter feed medium, pH was adjusted to 7.3-7.5, as described in patent application No.: 201710037400.3 continuous feeding production device and method for Zhongshengmycin fermentation, the method comprises preparing, feeding, fermenting, culturing, and measuring the content of Zhongshengmycin in the fermented liquid to 10.96 g/L. The method comprises the following steps of (1) performing liquid-solid separation on a fermentation liquor of a zhongshengmycin tank by a ceramic membrane system → concentrating a filtrate by a nanofiltration membrane system → uniformly mixing the concentrated solution and a solid substance separated by the ceramic membrane system in proportion, and performing spray drying to obtain a zhongshengmycin mother medicine finished product, wherein the quality indexes of the zhongshengmycin mother medicine finished product are as follows:
the COD content measuring method is a COD content measuring method known in the industry.
The NH3The method for determining the-N content is NH known in the art3-N content determination method.
The determination method of the content of the zhongshengmycin is an antibiotic microorganism detection method.
The above description is merely a general example of the present invention, and is not intended to limit the scope of the present invention. Therefore, all changes and modifications made in the spirit and scope of the present invention shall fall within the scope of the present invention.
Claims (1)
1. A clean production method of a Zhongshengmycin mother drug is characterized by comprising the following steps: adding the secondary rhzomorph fermentation tank placing and washing water into the secondary rhzomorph placing fermentation liquid of the batch on the same day, carrying out liquid-solid separation on the secondary rhzomorph placing fermentation liquid through a ceramic membrane system, concentrating the obtained filtrate of the ceramic membrane system through a nanofiltration membrane system, obtaining a secondary rhzomorph concentrated solution and a filtrate of the nanofiltration membrane system, and using the filtrate of the nanofiltration membrane system as the water for preparing the secondary rhzomorph fermentation culture medium or the supplementary culture medium of another batch in continuous production;
adding the clean washing water of a zhongshengmycin spray tower and water foam in the spraying process to remove dust from wastewater, adding the clean washing water of a ceramic membrane system and a nanofiltration membrane system into another batch of zhongshengmycin tank fermentation liquor, carrying out liquid-solid separation on the zhongshengmycin tank fermentation liquor by virtue of a ceramic membrane system, concentrating the filtrate of the ceramic membrane system by virtue of a nanofiltration membrane system to obtain zhongshengmycin concentrated solution and filtrate of the nanofiltration membrane system, and taking the filtrate of the nanofiltration membrane system as water for preparing another batch of zhongshengmycin fermentation culture medium or supplement culture medium in continuous production;
the tank placing and washing water of the zhongshengmycin fermentation tank is the tank washing water after the seed tank is transferred, the tank washing water after the material supplementing of the material supplementing tank and the tank washing water after the fermentation tank is placed;
the filtered permeate of the nanofiltration membrane system is the permeate of the nanofiltration membrane system which permeates the nanofiltration membrane system in the process of concentrating the filtrate of the ceramic membrane system;
the water in the spray tower is wastewater collected by cleaning and washing the spray tower after the zhongshengmycin concentrated solution is subjected to spray drying to obtain a powdery zhongshengmycin mother medicine finished product;
the water foam dedusting wastewater in the spraying process is collected wastewater obtained by removing dust from trace dust carried by tail gas of the zhongshengmycin concentrated solution in the spraying drying process by adopting a water foam dedusting process;
the membrane system cleaning water is wastewater collected by cleaning and washing equipment of a ceramic membrane system and a nanofiltration membrane system after the liquid-solid separation of the fermentation liquor of the zhongshengmycin storage tank and the concentration of the nanofiltration membrane system are finished.
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| CN111349662B (en) * | 2020-04-29 | 2021-01-08 | 吉林中粮生化有限公司 | Method for preparing PHA (polyhydroxyalkanoate) by fermenting PHA fermentation process wastewater |
| CN113603731B (en) * | 2021-09-14 | 2024-02-06 | 陕西麦可罗生物科技有限公司 | Method for separating Zhongshengmycin |
| CN114196580B (en) * | 2021-12-14 | 2023-03-28 | 福建凯立生物制品有限公司 | Streptomyces lavendulae Hainan variant strain and method for preparing zhongshengmycin product by using same |
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| CN101392273A (en) * | 2008-11-10 | 2009-03-25 | 南京工业大学 | Clean production process of lactic acid |
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