CN106860756A - 眼睑痉挛的治疗药物 - Google Patents

眼睑痉挛的治疗药物 Download PDF

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CN106860756A
CN106860756A CN201710199335.4A CN201710199335A CN106860756A CN 106860756 A CN106860756 A CN 106860756A CN 201710199335 A CN201710199335 A CN 201710199335A CN 106860756 A CN106860756 A CN 106860756A
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卢仁华
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Abstract

本发明涉及眼睑痉挛的治疗药物，医药技术领域，解决眼睑痉挛的治疗药物问题，其特征是按下面各中药质量份比组合而成：寒水石10份、桑寄生10份、人参12份、栀子12份、乌梅15份、生地12份、菟丝子10份、珍珠粉3份、元参12份、丹皮10份、泽泻10份、独活10份、寸冬9份、五加皮9份。

Description

眼睑痉挛的治疗药物
技术领域
本发明涉及眼睑痉挛的治疗药物，特别涉及以多种中药组合的治疗药物，属于医药技术领域。
背景技术
眼睑痉挛是一种不明原因的、不自主的 面神经支配区肌肉的痉挛和抽搐，多发于中老年人，是眼科常见的疾病之一，给患者经审核身体带来极大的痛苦，也极其影响美观。
眼睑痉挛由于眼轮匝肌痉挛性收缩引起的眼睑不随意的闭合。常为双侧病变，呈进行性进展。 2/3为女性，多在 60岁以上发病。其病因未明。偶见有脑干病变者。痉挛的频率和时间不等，严重者可引起病人功能性的失明。大多数病人的症状在3～5年内稳定。1/3的病人有相关的运动异常，如：Meige综合征、原发性震颤或帕金森病。诊断时应除外：角、结膜炎，倒睫和睑缘炎引起的继发性眼睑痉挛。
眼睑痉挛，患者除眼睑痉挛外，还有眉，下面部如口唇、下颌、颈部、软聘的运动障碍。这种病人常有吸嘴、咀嚼、开颌、构音障碍和发音障碍等症状。有人认为良性原发性眼睑痉挛是一种小块发作的Meige综合征。
眼睑痉挛分原发性和继发性两种：①原发性：病初眼睑（眼轮匝肌）微细抽动。重者一侧全部面肌阵挛性和强直性收缩，常致眼睑闭合而影响视物。多见于中老年女性，原因不明。部分病人系硬化血管拌对神经于的交叉压迫引起。②继发性：临床表现与原发性类似，一般较轻，常见病因为基底动脉瘤、岩骨锥部肿瘤及面神经管内的上皮细胞瘤或神经纤维瘤等。面神经麻痹后的眼轮匝肌和面肌痉挛多为强直性。
半侧面肌眼睑痉挛痉挛是累及单侧的病变，面肌周期性的强直性收缩。痉挛通常从眼轮匝肌开始，逐渐扩展到面肌的其他部分，无论病人清醒或在睡眠时均可发作。常起自中年，女性多见。可伴有同侧面肌无力。虽然有痉挛，受累一侧的眼轮匝肌常较健侧无力。发病机制为异位的/神经元间接触的兴奋和“点燃”效应的理论。由于机械性刺激的损害（脱髓鞘改变），神经对异位兴奋有较低的阈值。一个神经元的极化改变通过激活很多异位的被损害的轴突，可产生大的效应，称为“点燃”效应。这种“点燃”效应是由于面神经核的过度应激性引起的。面神经外伤或麻痹后的第七颅神经迷走再生常引起异常的面部运动，其表现与半侧面肌痉挛相同。
眼睑痉挛的治疗，注射治疗方法：使用TB针头在距睑缘2—3mm处做皮下或肌肉注射，分别于上、下眼睑中内1/3和中外1/3处及外眦颞侧皮下眼轮匝肌注射共4—5个位点。推荐的剂量范围是：5-25个单位/睑，5—75个单位/眼。效果：国外报道其有效率为93.3%，注射后最大作用出现在数天内，1—5天 痉挛症状减轻或消失，痉挛缓解持续5.9—104周。药物治疗包括 卡马西平、安定、 苯妥英钠等，以及 生物反馈法，手术治疗包括肌肉切除术。选择性面神经切除术。但可产生听力丧失、 中耳炎、 脑脊液漏等并发症。
发明内容
以中医学观点分析眼睑痉挛，属于心肾气虚，痰气上冲，虚火上炎，治疗应以滋肾气、解痉化痰之中药结合作治疗药物为解决方案。
眼睑痉挛的治疗药物是按下面各中药质量份比组合而成：寒水石10份、桑寄生10份、人参12份、栀子12份、乌梅15份、生地12份、菟丝子10份、珍珠粉3份、元参12份、丹皮10份、泽泻10份、独活10份、寸冬9份、五加皮9份。
下面对眼睑痉挛的治疗药物中各中药成分的药性功效进行分析。寒水石清热降火，利窍，消肿，治时行热病，积热烦渴，吐泻，水肿。桑寄生 ，味苦、甘，性平；功效：补肝肾；强筋骨；祛风湿；安胎；主腰膝酸痛；筋骨痿弱；肢体偏枯；风湿痹痛；头错目眩；胎动不安，崩漏下血。人参味甘微苦, 性症偏温, 其功重在大补正元之气, 以壮生命之本, 进而固脱、益损、止渴、安神。 栀子味苦; 归心、肺、三焦经；功效：泻火除烦, 清肝活血、清热利尿, 凉血解毒。乌梅的功效: 祛风化痰、抗菌 ，收敛生津。生地清肝热、活血凉血，养阴生津。菟丝子性甘、温,归肾、肝、经,具有滋补肝肾、固精缩尿、安胎、明目、止泻之功效。珍珠粉， 味甘、咸，性寒；归心、肝经；功效：安神定惊；清肝明目；解毒生肌；主治惊悸怔仲；心烦失眠；惊风癫痫；目赤翳障；口舌生疮；咽喉溃腐；疮疡久不收口。元参味苦、咸、寒, 属补益药；主要功能是:补气明目、滋阴降火,解毒软坚、清热消散郁结之痰火。丹皮清热，凉血，和血，消瘀，治热入血分，发斑，惊痫。泽泻利水，渗湿，泄热，治小便不利，水肿胀满，呕吐，泻痢，痰饮，脚气，淋病，尿血。独活的功效与作用: 祛风胜湿; 散寒止痛；用于风寒湿痹; 腰膝疼痛; 少阴伏风头痛, 头痛齿痛。寸冬就是麦冬 ， 功效： 养阴生津，润肺止咳，用于肺胃阴虚之津少口渴、干咳咯血；心阴不足之心悸易惊及热病后期热伤津液等证。五加皮是五加科植物细柱五加的干燥根皮；五加皮有祛风湿, 补肝肾,强筋骨的功效与作用。
眼睑痉挛的治疗药物的有益效果是：眼睑痉挛的治疗药物通过以中医学观点分析眼睑痉挛，属于心肾气虚，痰气上冲，虚火上炎，采取以滋肾气、解痉化痰之中药结合作治疗药物为解决方案，应用于治疗较果显著，疗效稳定。
具体实施方式
下面以一个眼睑痉挛患者的服用的药量作为优选实施例进一步的说明。
眼睑痉挛的治疗药物适合一个眼睑痉挛患者服用的一个剂量药量是按下面的药物量组合而成：寒水石10克、桑寄生10克、人参12克、栀子12克、乌梅15克、生地12克、菟丝子10克、珍珠粉3克、元参12克、丹皮10克、泽泻10克、独活10克、寸冬9克、五加皮9克。服用方法：煎汤内服，一天服用一个剂量，连服五个剂量症状即可减轻，后可以改为两天服用一个剂量。

Claims (1)

1.眼睑痉挛的治疗药物，其特征是按下面各中药质量份比组合而成：寒水石10份、桑寄生10份、人参12份、栀子12份、乌梅15份、生地12份、菟丝子10份、珍珠粉3份、元参12份、丹皮10份、泽泻10份、独活10份、寸冬9份、五加皮9份。
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CN101167927A (zh) * 2007-10-25 2008-04-30 寇连翠 治疗眼脸痉挛的中药方剂
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