CN106859814B - A kind of method of 3D printing manufacture artificial blood vessel - Google Patents
A kind of method of 3D printing manufacture artificial blood vessel Download PDFInfo
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- CN106859814B CN106859814B CN201710145060.6A CN201710145060A CN106859814B CN 106859814 B CN106859814 B CN 106859814B CN 201710145060 A CN201710145060 A CN 201710145060A CN 106859814 B CN106859814 B CN 106859814B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
- B29C33/40—Plastics, e.g. foam or rubber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/005—Templates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
Abstract
A kind of method that the present invention manufactures artificial blood vessel for 3D printing, belongs to artificial blood vessel technical field.It includes the following steps：1）Establish vascular pattern；2）The vascular pattern of foundation is converted into the STL forms that 3D printer can identify using three-dimensional drawing software；3）, by STL formatted files import 3D printer in；4）, using 3D printer vascular pattern is printed to form blood vessel mould；5）, obtained blood vessel mould put and in an oven melt wax, then hot water continuous flushing blood vessel mould is to remove the wax of remnants；6）, polishing blood vessel mould inside；7）, degassing 3 ~ 5 times；8）, between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will stand it is fixed and cure 24 it is small when ~ 48 it is small when；9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out the artificial blood vessel that layer of silica gel is formed.Product obtained by the method for the present invention has the advantages that precision is high, quality is high, high yield rate.
Description
Technical field
The present invention relates to a kind of preparation method of artificial blood vessel, particularly discloses a kind of side of 3D printing manufacture artificial blood vessel
Method.
Background technology
Angiocardiopathy（cardiovascular disease, CVD）With very strong concealment and sudden, it is
Nowadays the highest disease of world's morbidity and mortality.In China, the generation of angiocardiopathy also has the trend of rejuvenation, therefore should
It is particularly important that prevention of class disease becomes, the research to such disease also should more be paid attention to.
It is also growing day by day to the demand of various artificial blood vessels with the raising of incidence.Artificial blood vessel can be divided into two classes, and one
Class is clinical transplantation artificial blood vessel, is made more of artificial polymeric biomaterial.Another kind of is research artificial blood vessel, existing
There is manufacturing technology to include leaching modulus method, rotation leaching modulus method and lost-wax process, but the method for conventionally manufactured artificial blood vessel hardly results in
Complicated blood vessel, such as the angle of forking that real blood vessels have, curvature, changeable blood vessel diameter and vessel wall thickness etc..
In the prior art, clinical transplantation is with the manufacture method of artificial blood vessel：1) 3D scanning machines and medical imaging skill are passed through
Art or the geometrical model that blood vessel is obtained by three-dimensional modeling；2）Entity artificial blood vessel mould is made with reference to rapid shaping technique；
3）Mould is immersed in silica gel or latex solution, repeatedly allows solution to be attached to die surface and cures；4) mould is removed,
Obtain flexible artificial blood vessel.
The artificial blood vessel obtained using this method, the drawback is that vessel wall thickness is uneven, discontinuously, cost is expensive.
Leaching modulus method used by research artificial blood vessel, the drawback is that：It is attached to the layer of silica gel uneven thickness of die surface
It is even, cause final vascular pattern surface rugged and rough.
The rotation leaching modulus method of use, the drawback is that：The vessel wall thickness for being attached to die surface is discontinuous.
The shortcomings that lost-wax process is：Using wax as mold materials, chemistry or the side of heating are used after surface attachment silica gel
Method removes paraffin removal, but wax material is very expensive, and printing precision is not so good as solid material, and it is high to be not suitable for making complicated and required precision
Blood vessel.
The content of the invention
It is an object of the invention to overcome problems of the prior art, there is provided a kind of obtained artificial blood vessel wall thickness
Uniformly, continuously, cost is low, precision is high, and artificial blood vessel is not only flexible but also its mechanical property and real blood vessels are very close
The method that 3D printing manufactures artificial blood vessel.
What the present invention was realized in：A kind of method of 3D printing manufacture artificial blood vessel, it is characterised in that：Including following step
Suddenly：
1）, vascular pattern, including external mold and kernel are established using three-dimensional drawing software；Or obtained using image processing software
The three-dimensional data of the real blood vessels in CT or MR images is taken, then the three-dimensional data of acquisition is imported into the three-dimensional drawing software and is carried out
Post processing, the outside diameter using the internal diameter of the blood vessel of the three-dimensional data of importing as model kernel, with the blood vessel of the three-dimensional data of importing
Internal diameter of the outside diameter as model external mold, establish vascular pattern；
2）, using three-dimensional drawing software the vascular pattern established is converted into the STL forms that 3D printer can identify；
3）, the identifiable STL formatted files of 3D printer are imported in 3D printer；
4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing institute
The material for stating external mold and kernel is polypropylene or polyvinyl acetate or polyvinyl chloride, and printing precision is 0.01mm ~ 0.03mm, kernel
Packing material between external mold is wax；
5）, the blood vessel mould that step 4 obtains is placed in 70 DEG C -80 DEG C of oven and melts wax, then using 70 DEG C -80
DEG C hot water continuous flushing blood vessel mould with remove remnants wax；
6）, polishing blood vessel mould inside, 70 DEG C -80 DEG C of hot water is connected with minute solid particles intermixture by force (forcing) pump
Afterflow intravascular mould inside, plays the role of smooth interior；The minute solid particles intermixture is in cubic boron nitride particle, people
Make in diamond particles, white fused alumina particle, silicon-carbide particle or alumina particle and choose any one kind of them；
7）, degassing, 500mmgh-600mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur
Until disappearing, the process of degassing needs to repeat 3 ~ 5 times；
8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will
Its stand it is fixed and cure 24 it is small when ~ 48 it is small when, keep room temperature in 20 DEG C -25 DEG C and humidity in 45%-55%；Wherein, the silicon
The volume ratio of rubber and catalyst is 10:1；
9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out silica gel
The artificial blood vessel that layer is formed.
In step 1, the three-dimensional drawing software is chosen any one kind of them in UG, SolidWorks or CATIA.
In step 1, described image processing software is Mimics.
In step 4, the printing type of the 3D printer is the more nozzle printing modes of MJP or SLM selective laser meltings
It is molded printing type.
In step 8, the silicon rubber penylene and phenylate support silicon rubber, dimethyl silicone rubber, methyl vinyl silicone rubber,
Choose any one kind of them in methyl phenyl vinyl silicone rubber or nitrile silicone rubber, the catalyst is in ethyl orthosilicate or dibutyl tin osmanthus
Choose any one kind of them in sour tin.
The beneficial effects of the invention are as follows：1）Precision is high, by controlling the space between inside and outside shell accurately to control blood vessel
The thickness of wall；2. mass is high, flowing in series through mould inside by using 70 DEG C of -80 DEG C of hot water and minute solid particles plays polishing
Effect；3. high yield rate, each step of technological process can be controlled accurately, so there is higher finished product compared to conventional method
Rate.
Embodiment
A kind of method of 3D printing manufacture artificial blood vessel of the present invention, includes the following steps：
1）, vascular pattern, including external mold and kernel are established using three-dimensional drawing software；Or obtained using image processing software
The three-dimensional data of the real blood vessels in CT or MR images is taken, then the three-dimensional data of acquisition is imported into the three-dimensional drawing software and is carried out
Post processing, the outside diameter using the internal diameter of the blood vessel of the three-dimensional data of importing as model kernel, with the blood vessel of the three-dimensional data of importing
Internal diameter of the outside diameter as model external mold, establish vascular pattern；Wherein, the three-dimensional drawing software in UG, SolidWorks or
Choose any one kind of them in CATIA；Described image processing software is Mimics.
2）, using three-dimensional drawing software the vascular pattern established is converted into the STL forms that 3D printer can identify.
3）, the identifiable STL formatted files of 3D printer are imported in 3D printer.
4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing institute
The material for stating external mold and kernel is polypropylene or polyvinyl acetate or polyvinyl chloride, and printing precision is 0.01mm ~ 0.03mm, kernel
Packing material between external mold is wax；The printing type of the 3D printer is the more nozzle printing modes of MJP or SLM selectivity
Laser fusion is molded printing type.
5）, the blood vessel mould that step 4 obtains is placed in 70 DEG C -80 DEG C of oven and melts wax, then using 70 DEG C -80
DEG C hot water continuous flushing blood vessel mould with remove remnants wax.
6）, polishing blood vessel mould inside, 70 DEG C -80 DEG C of hot water is connected with minute solid particles intermixture by force (forcing) pump
Afterflow plays the role of smooth interior through mould inside；The minute solid particles intermixture is in cubic boron nitride particle, artificial gold
Choose any one kind of them in hard rock particle, white fused alumina particle, silicon-carbide particle or alumina particle.
7）, degassing, 500mmgh-600mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur
Until disappearing, the process of degassing needs to repeat 3 ~ 5 times.
8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will
Its stand it is fixed and cure 24 it is small when ~ 48 it is small when, keep room temperature in 20 DEG C -25 DEG C and humidity in 45%-55%；Wherein, the silicon
The volume ratio of rubber and catalyst is 10:1；The silicon rubber is in penylene and phenylate support silicon rubber, dimethyl silicone rubber, methyl second
Choose any one kind of them in alkenyl silicon rubber, methyl phenyl vinyl silicone rubber or nitrile silicone rubber, the catalyst in ethyl orthosilicate or
Choose any one kind of them in dibutyl tin dilaurate.
9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out silica gel
The artificial blood vessel that layer is formed.
The present invention is further elaborated below by specific embodiment：
Embodiment one：
The present embodiment includes the following steps：
1）, vascular pattern, including external mold and kernel are established using three-dimensional drawing software SolidWorks；
2）, the vascular pattern using three-dimensional drawing software SolidWorks established step 1 is converted into 3D printer can be with
The STL forms of identification.
3）, the identifiable STL formatted files of 3D printer are imported in 3D printer.
4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing institute
The material for stating external mold and kernel is polypropylene, and printing precision 0.01mm, the packing material between kernel and external mold is wax；It is described
The printing type of 3D printer is the more nozzle printing modes of MJP.
5）, the blood vessel mould that step 4 obtains is placed in 70 DEG C of oven and melts wax, then using 70 DEG C hot water connect
It is continuous to rinse blood vessel mould to remove the wax of remnants.
6）, polishing blood vessel mould inside, 70 DEG C of hot water and minute solid particles intermixture are passed through into force (forcing) pump continuous stream
Intravascular mould inside, plays the role of smooth interior；The minute solid particles intermixture uses cubic boron nitride particle.
7）, degassing, 500mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur until disappearance,
The process of degassing needs to be repeated 3 times.
8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will
Its stand it is fixed and cure 24 it is small when, keep room temperature in 20 DEG C and humidity 45%.Wherein, the body of the silicon rubber and catalyst
Product is than being 10:1；The silicon rubber uses ethyl orthosilicate using penylene and phenylate support silicon rubber, the catalyst.
9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out silica gel
The artificial blood vessel that layer is formed.
Advantage of this embodiment is that：1. precision is high, by controlling the space between external mold and kernel accurately to control blood
The thickness of tube wall；2. blood vessel surface roughness is low, blood vessel mould is flowed in series through by using 70 DEG C of hot water and minute solid particles
Play the role of polishing in inside；3. high yield rate, each step of technological process can be controlled accurately, so comparing conventional method
There is higher yield rate；4. the heat-resisting quantity of artificial blood vessel is excellent；It is vapor permeability good that 5. the moistureproof and mildewproof of artificial blood vessel is water-fast；6.
The radiation resistance of artificial blood vessel and dielectric properties are good；7. blood vessel elasticity modulus is close to human body actual value.
Embodiment two：
The present embodiment includes the following steps：
1）, obtain using image processing software Mimics the three-dimensional datas of the real blood vessels in CT images, then by acquisition
Three-dimensional data imports the three-dimensional drawing software and is post-processed, using the internal diameter of the blood vessel of the three-dimensional data of importing as model in
The outside diameter of core, the internal diameter using the outside diameter of the blood vessel of the three-dimensional data of importing as model external mold, establishes vascular pattern；Wherein, institute
Three-dimensional drawing software is stated to choose any one kind of them in UG, SolidWorks or CATIA；Described image processing software is Mimics.
2）, using three-dimensional drawing software the vascular pattern established is converted into the STL forms that 3D printer can identify.
3）, the identifiable formatted file of 3D printer imported in 3D printer.
4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing institute
The material for stating external mold and kernel is polyvinyl acetate, and printing precision 0.03mm, the packing material between kernel and external mold is wax；
The printing type of the 3D printer is molded printing type for SLM selective laser meltings.
5）, the blood vessel mould that step 4 obtains is placed in 75 DEG C of oven and melts wax, then using 75 DEG C hot water connect
It is continuous to rinse blood vessel mould to remove the wax of remnants.
6）, polishing blood vessel mould inside, 80 DEG C of hot water and minute solid particles intermixture are passed through into force (forcing) pump continuous stream
Through mould inside, play the role of smooth interior；The minute solid particles intermixture is synthetic diamond particles.
7）, degassing, 600mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur until disappearance,
The process of degassing needs to be repeated 5 times.
8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will
Its stand it is fixed and cure 36 it is small when, keep room temperature in 25 DEG C and humidity 55%；Wherein, the body of the silicon rubber and catalyst
Product is than being 10:1；The silicon rubber uses methyl vinyl silicone rubber, and the catalyst is dibutyl tin dilaurate.
9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out silica gel
The artificial blood vessel that layer is formed.
Advantage of this embodiment is that：1. precision is high, by controlling the space between inside and outside shell accurately to control vascular wall
Thickness；2. blood vessel surface roughness is low, blood vessel mould inside is flowed in series through by using 80 DEG C of hot water and minute solid particles
Play the role of polishing；3. high yield rate, each step of technological process can be controlled accurately, thus compared to conventional method have compared with
High yield rate；4. blood vessel elasticity modulus is close to human body actual value；5. the high temperature resistant of artificial blood vessel is good with low temperature properties；It is 6. artificial
The ageing-resistant and ozone resistance of blood vessel is good.
Embodiment three：
The present embodiment includes the following steps：
1）, obtain using image processing software Mimics the three-dimensional datas of the real blood vessels in MR images, then by acquisition
Three-dimensional data imports the three-dimensional drawing software UG and is post-processed, and model is used as using the internal diameter of the blood vessel of the three-dimensional data of importing
The outside diameter of kernel, the internal diameter using the outside diameter of the blood vessel of the three-dimensional data of importing as model external mold, establishes vascular pattern.
2）, using three-dimensional drawing software UG the vascular pattern established is converted into the STL lattice that 3D printer can identify
Formula.
3）, the identifiable STL formatted files of 3D printer are imported in 3D printer.
4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing institute
The material for stating external mold and kernel is polyvinyl chloride, and printing precision 0.02mm, the packing material between kernel and external mold is wax；Institute
The printing type for stating 3D printer is the more nozzle printing modes of MJP.
5）, the blood vessel mould that step 4 obtains is placed in 80 DEG C of oven and melts wax, then using 80 DEG C hot water connect
It is continuous to rinse blood vessel mould to remove the wax of remnants.
6）, polishing blood vessel mould inside, 75 DEG C of hot water and minute solid particles intermixture are passed through into force (forcing) pump continuous stream
Through mould inside, play the role of smooth interior；The minute solid particles intermixture is silicon-carbide particle.
7）, degassing, 550mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur until disappearance,
The process of degassing needs to be repeated 4 times.
8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, will
Its stand it is fixed and cure 48 it is small when, keep room temperature in 23 DEG C and humidity 50%；Wherein, the body of the silicon rubber and catalyst
Product is than being 10:1；The silicon rubber uses nitrile silicone rubber, and the catalyst is ethyl orthosilicate.
9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out silica gel
The artificial blood vessel that layer is formed.
Advantage of this embodiment is that：1. precision is high, by controlling the space between inside and outside shell accurately to control vascular wall
Thickness；2. blood vessel surface roughness is low, blood vessel mould inside is flowed in series through by using 75 DEG C of hot water and minute solid particles
Play the role of polishing；3. high yield rate, each step of technological process can be controlled accurately, thus compared to conventional method have compared with
High yield rate；4. blood vessel elasticity modulus is close to human body actual value；5. the oil resistivity of artificial blood vessel is good；6. the blood of artificial blood vessel
Pipe fatigue life is grown.
Claims (5)
- A kind of 1. method of 3D printing manufacture artificial blood vessel, it is characterised in that：Include the following steps：1）, vascular pattern, including external mold and kernel are established using three-dimensional drawing software；Or obtain CT using image processing software Or the three-dimensional data of the real blood vessels in MR images, then the three-dimensional data of acquisition is imported after the three-dimensional drawing software carries out and is located Reason, the outside diameter using the internal diameter of the blood vessel of the three-dimensional data of importing as model kernel, with the outer of the blood vessel of the three-dimensional data of importing Internal diameter of the footpath as model external mold, establishes vascular pattern；2）, the vascular pattern using three-dimensional drawing software established step 1 be converted into the STL forms that 3D printer can identify；3）, the identifiable STL formatted files of 3D printer are imported in 3D printer；4）, using 3D printer vascular pattern is printed to form blood vessel mould；Wherein described 3D printer printing is described outer The material of mould and kernel is polypropylene or polyvinyl acetate or polyvinyl chloride, and printing precision is 0.01mm ~ 0.03mm, kernel with it is outer Packing material between mould is wax；5）, the blood vessel mould that step 4 obtains is placed in 70 DEG C -80 DEG C of oven and melts wax, then using 70 DEG C -80 DEG C Hot water continuous flushing blood vessel mould with remove remnants wax；6）, polishing blood vessel mould inside, 70 DEG C -80 DEG C of hot water and minute solid particles intermixture are passed through into force (forcing) pump continuous stream Intravascular mould inside, plays the role of smooth interior；The minute solid particles intermixture is in cubic boron nitride particle, artificial gold Choose any one kind of them in hard rock particle, white fused alumina particle, silicon-carbide particle or alumina particle；7）, degassing, 500mmgh-600mmgh vacuum depress carry out blood vessel mould degassing, have bubble from surface occur up to Disappear, the process of degassing needs to repeat 3 ~ 5 times；8）, after the completion of degassing by between the kernel and external mold of the mixed liquor of silicon rubber and catalyst injection blood vessel mould, its is quiet Put it is fixed and cure 24 it is small when ~ 48 it is small when, keep room temperature in 20 DEG C -25 DEG C and humidity in 45%-55%；Wherein, the silicon rubber Volume ratio with catalyst is 10:1；9）, after the curing of the mixed liquor of silicon rubber and catalyst form layer of silica gel, by kernel and broken mold, take out layer of silica gel shape Into artificial blood vessel.
- A kind of 2. method of 3D printing manufacture artificial blood vessel according to claim 1, it is characterised in that：In step 1, institute Three-dimensional drawing software is stated to choose any one kind of them in UG, SolidWorks or CATIA.
- A kind of 3. method of 3D printing manufacture artificial blood vessel according to claim 1, it is characterised in that：In step 1, institute It is Mimics to state image processing software.
- A kind of 4. method of 3D printing manufacture artificial blood vessel according to claim 1, it is characterised in that：In step 4, institute The printing type for stating 3D printer is molded printing type for the more nozzle printing modes of MJP or SLM selective laser meltings.
- A kind of 5. method of 3D printing manufacture artificial blood vessel according to claim 1, it is characterised in that：In step 8, institute Silicon rubber is stated in penylene and phenylate support silicon rubber, dimethyl silicone rubber, methyl vinyl silicone rubber, methyl phenyl vinyl silicon rubber Choose any one kind of them in glue or nitrile silicone rubber, the catalyst is chosen any one kind of them in ethyl orthosilicate or dibutyl tin dilaurate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710145060.6A CN106859814B (en) | 2017-03-13 | 2017-03-13 | A kind of method of 3D printing manufacture artificial blood vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710145060.6A CN106859814B (en) | 2017-03-13 | 2017-03-13 | A kind of method of 3D printing manufacture artificial blood vessel |
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| Publication Number | Publication Date |
|---|---|
| CN106859814A CN106859814A (en) | 2017-06-20 |
| CN106859814B true CN106859814B (en) | 2018-05-08 |
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| CN108081515A (en) * | 2017-12-25 | 2018-05-29 | 南通东概念新材料有限公司 | A kind of method of the external bionic-mouse stomach model of 3D printing |
| KR102200859B1 (en) * | 2018-12-20 | 2021-01-12 | 성균관대학교산학협력단 | Method for manufacturing cell-laden scaffold for tissue regeneration using cell electrospinning |
| CN109523887A (en) * | 2018-12-29 | 2019-03-26 | 北京工业大学 | A kind of preparation method of the bionical vascular pattern of high transparency for hydrodynamics observation experiment |
| CN109674558B (en) * | 2019-03-08 | 2021-03-16 | 北京工业大学 | Method for preparing highly smooth and transparent aorta root based on plasma corona method |
| CN110328793B (en) * | 2019-06-04 | 2021-07-13 | 青岛雀鹏数字医学有限公司 | Method for manufacturing human body bionic blood vessel by combining 3D printing with rollover process |
| CN110587883A (en) * | 2019-08-30 | 2019-12-20 | 宁波安影医疗科技有限公司 | Manufacturing process of silica gel blood vessel model |
| CN111227930B (en) * | 2020-01-08 | 2022-11-11 | 西安马克医疗科技有限公司 | 3D model construction and preparation method for mitral regurgitation and calcified stenosis |
| CN111227931B (en) * | 2020-01-08 | 2022-11-11 | 西安马克医疗科技有限公司 | 3D model construction method and preparation method for aortic valve diseases |
| CN111938866A (en) * | 2020-05-08 | 2020-11-17 | 领博生物科技(杭州)有限公司 | Special-shaped blood vessel model or artificial blood vessel and preparation method thereof |
| CN112497728A (en) * | 2020-09-28 | 2021-03-16 | 西安增材制造国家研究院有限公司 | Method for preparing bionic hollow human body part model through 3D printing |
| CN114515357B (en) * | 2021-12-31 | 2022-12-09 | 西安交通大学 | Manufacturing method of 3D printed sound-simulating blood vessel and sound-simulating blood vessel model |
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