CN106835699A - A kind of antibacterial hemostatic gauze and preparation method thereof - Google Patents
A kind of antibacterial hemostatic gauze and preparation method thereof Download PDFInfo
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- CN106835699A CN106835699A CN201710066735.8A CN201710066735A CN106835699A CN 106835699 A CN106835699 A CN 106835699A CN 201710066735 A CN201710066735 A CN 201710066735A CN 106835699 A CN106835699 A CN 106835699A
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M14/00—Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics, or fibrous goods made from such materials
- D06M14/18—Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics, or fibrous goods made from such materials using wave energy or particle radiation
- D06M14/20—Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics, or fibrous goods made from such materials using wave energy or particle radiation on to materials of natural origin
- D06M14/22—Graft polymerisation of monomers containing carbon-to-carbon unsaturated bonds on to fibres, threads, yarns, fabrics, or fibrous goods made from such materials using wave energy or particle radiation on to materials of natural origin of vegetal origin, e.g. cellulose or derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The present invention relates to medicine equipment articles for use preparing technical field, a kind of antibacterial hemostatic gauze and preparation method thereof is disclosed.The present invention obtains antibacterial hemostatic gauze by preparing the irradiation grafting of doped quaternary ammonium salt monomer and medical absorbent cotton gauze, the antibacterial hemostatic gauze not only has hemostatic function, and with excellent anti-microbial property, it is not required to add hemostasis, anti-inflammatory rapidly by any medicine, antibacterial hemostatic gauze of the invention is contact-type antibacterial, and the purpose of antibacterial is not reached by delivery of antimicrobials.
Description
Technical field
The present invention relates to medicine equipment articles for use preparing technical field, and in particular to a kind of antibacterial hemostatic gauze and its preparation side
Method.
Background technology
According to statistics, the principal element that death is caused on battlefield is excessive blood loss, accounts for 50% or so of sum, and in peace
In period, because 39% dies from excessive blood loss in the dead people of wound, the bleeding not being effectively controlled has been the second of died of wounds
Big leading factor.Even if bleeding can be controlled gradually in a long time, excessive losing blood would generally also cause the wounded's surface of a wound
The serious consequences such as infection, hypothermia, coagulation disorders or multiple organ's exhaustion.
Existing common hemostatic gauze does not possess antibacterial functions, and haemostatic effect is poor.Some the new gauzes for occurring at present
Even if having antibacterial functions, the antiseptics such as antibacterials or Nano Silver are typically all added, antibacterials are so still present
The enrichment problem of the antiseptic such as problem of resistance and the Nano Silver that discharges.Therefore, it is a kind of to have hemostasis concurrently with antibacterial functions
Hemostatic gauze, and be the medical supplies hemostatic gauze for contacting antibacterial, the hemostasis of clinical treatment use demand can be better met
Gauze is existing market in the urgent need to.
The content of the invention
It is an object of the invention to solve the problems, such as prior art, a kind of antibacterial hemostatic gauze and its preparation side are proposed
Method, the antibacterial hemostatic gauze obtained by preparation method disclosed by the invention not only has hemostatic function, and resists with excellent
Bacterium performance, is not required to add hemostasis, anti-inflammatory rapidly by any medicine, and antibacterial hemostatic gauze of the invention is contact-type antibacterial, no
The purpose of antibacterial is reached by delivery of antimicrobials.Irradiation by preparing doped quaternary ammonium salt monomer and medical absorbent cotton gauze of the invention
Grafting obtains antibacterial hemostatic gauze.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of preparation method of antibacterial hemostatic gauze,
The preparation method is comprised the following steps that：
The preparation of S1, doped quaternary ammonium salt monomer：With dichloromethane as solvent, 200ml dichloromethane is added in single port bottle, in mass ratio
It is 2.5：1~1：1.5 add methacrylic acid 2-（N, N- dimethyl amido）Ethyl ester（DMAE）And benzyl chloride, add to benzene two
Phenol is cooled down as polymerization inhibitor, heating reflux reaction, reaction after terminating, and has a large amount of white crystals to separate out, and suction filtration uses dichloromethane weight
Twice, the air drying in vacuum drying oven is obtained methylacryoyloxyethyl-benzyl-dimethyl ammonium chloride monomer, as crystallization
Doped quaternary ammonium salt monomer；
S2, medical absorbent cotton gauze irradiation grafting：Medical absorbent cotton gauze, step S1 is added to obtain in the conical flask of 250ml
Doped quaternary ammonium salt monomer and 100ml deionized waters, nitrogen bubble 10min ~ 30min, sealing, use Co60Gamma-ray irradiation is grafted, and connects
After branch reaction terminates, medical absorbent cotton gauze is washed with acetone, then extract 12h, dried, obtain final product antibacterial hemostatic gauze.
Further, methacrylic acid 2- in described step S1（N, N- dimethyl amido）The addition of ethyl ester be 10g ~
20g, the addition of hydroquinones is 0.5g ~ 1.0g.
Further, the time of heating reflux reaction is 5h ~ 8h in described step S1.
Further, medical degreasing cotton gauze and the mass ratio of doped quaternary ammonium salt monomer are 1 in described step S2：2~2：1,
The addition of medical absorbent cotton gauze is 10g ~ 12g.
Further, Co in described step S260The time of gamma-ray irradiation grafting is 30min ~ 60min.
To achieve the above object, another technical scheme of the invention is：A kind of antibacterial hemostatic gauze, described antibacterial anti hemorrhagic
Gauze is prepared by the preparation method of antibacterial hemostatic gauze described above.
Common gauze is modified by doped quaternary ammonium salt in the present invention so that modified gauze has dissolubility, is connect with blood
Gel is dissolved as rapidly after touch so as to block blood outlet；By the common gauze that doped quaternary ammonium salt is modified so that modified is common
Gauze has been grafted doped quaternary ammonium salt monomer, and has two positively charged N in doped quaternary ammonium salt monomer molecule+, molecule is made by inducing action
In quaternary nitrogen on positive charge density increase, be conducive to biocide molecules in the absorption of bacterium surface, so as to change cell membrane
Permeability, ruptures thalline.
The present invention has the following advantages and effect relative to prior art：
（1）The antibacterial hemostatic gauze obtained by preparation method disclosed by the invention not only has excellent hemostatic function, and tool
There is excellent anti-microbial property, be not required to add hemostasis, anti-inflammatory rapidly by any medicine；Antibacterial hemostatic gauze is fast after blood is contacted
Instant solution forms spawn, sticks well in wound, forms physical barriers and oppresses blutpunkte.
（2）The antibacterial hemostatic gauze obtained by preparation method disclosed by the invention, its main component is doped quaternary ammonium salt fiber
Element, when with Wound contact, positively charged doped quaternary ammonium salt is adsorbed onto negatively charged antimicrobial surface to antibacterial hemostatic gauze, season ammonia
Salt penetration cell wall, is combined with the phospholipid bilayer in cell membrane and other electronegative species, destroys the composition of cell membrane, is caused
Intracellular matter such as RNA, DNA etc. are revealed, and cause the dead purpose so as to play antibacterial of microorganism, protect the effect of the surface of a wound.
（3）Antibacterial hemostatic gauze disclosed by the invention is different from other Wound antibiotic materials, and it is anti-that the present invention is prepared
Bacterium hemostatic gauze is contact-type antibacterial, and the purpose of antibacterial is not reached by delivery of antimicrobials.
Specific embodiment
Technical scheme is described further with reference to embodiment.
Embodiment 1
A kind of preparation method of antibacterial hemostatic gauze, the preparation method is comprised the following steps that：
The preparation of S1, doped quaternary ammonium salt monomer：With dichloromethane as solvent, 200ml dichloromethane is added in single port bottle, in mass ratio
It is 2.5：1 adds 10g methacrylic acids 2-（N, N- dimethyl amido）Ethyl ester（DMAE）With 4g benzyl chlorides, 0.5g is added to benzene
Diphenol is cooled down as polymerization inhibitor, heating reflux reaction 5h, reaction after terminating, and has a large amount of white crystals to separate out, and suction filtration uses dichloromethane
Alkane is recrystallized twice, and the air drying in vacuum drying oven is obtained methylacryoyloxyethyl-benzyl-dimethyl ammonium chloride monomer,
As doped quaternary ammonium salt monomer；
S2, medical absorbent cotton gauze irradiation grafting：10g medical absorbent cottons gauze, step S1 is added to obtain in the conical flask of 250ml
The doped quaternary ammonium salt monomer and 100ml deionized waters for arriving, the wherein mass ratio of medical absorbent cotton gauze and doped quaternary ammonium salt monomer are 1：2, nitrogen
Gas bell 10min, sealing, uses Co60Gamma-ray irradiation is grafted, and the time of irradiation grafting is 30min, after graft reaction terminates, uses
Acetone washs medical absorbent cotton gauze, then extracts 12h, dries, and obtains final product antibacterial hemostatic gauze.
Embodiment 2
A kind of preparation method of antibacterial hemostatic gauze, the preparation method is comprised the following steps that：
The preparation of S1, doped quaternary ammonium salt monomer：With dichloromethane as solvent, 200ml dichloromethane is added in single port bottle, in mass ratio
It is 1：1 adds 15g methacrylic acids 2-（N, N- dimethyl amido）Ethyl ester（DMAE）With 15g benzyl chlorides, 0.8g is added to benzene
Diphenol is cooled down as polymerization inhibitor, heating reflux reaction 7h, reaction after terminating, and has a large amount of white crystals to separate out, and suction filtration uses dichloromethane
Alkane is recrystallized twice, and the air drying in vacuum drying oven is obtained methylacryoyloxyethyl-benzyl-dimethyl ammonium chloride monomer,
As doped quaternary ammonium salt monomer；
S2, medical absorbent cotton gauze irradiation grafting：11g medical absorbent cottons gauze, step S1 is added to obtain in the conical flask of 250ml
The doped quaternary ammonium salt monomer and 100ml deionized waters for arriving, the wherein mass ratio of medical absorbent cotton gauze and doped quaternary ammonium salt monomer are 1：1, nitrogen
Gas bell 20min, sealing, uses Co60Gamma-ray irradiation is grafted, and the time of irradiation grafting is 45min, after graft reaction terminates, uses
Acetone washs medical absorbent cotton gauze, then extracts 12h, dries, and obtains final product antibacterial hemostatic gauze.
Embodiment 3
A kind of preparation method of antibacterial hemostatic gauze, the preparation method is comprised the following steps that：
The preparation of S1, doped quaternary ammonium salt monomer：With dichloromethane as solvent, 200ml dichloromethane is added in single port bottle, in mass ratio
It is 1：1.5 add 20g methacrylic acids 2-（N, N- dimethyl amido）Ethyl ester（DMAE）With 30g benzyl chlorides, 1.0g pairs is added
Benzenediol is cooled down as polymerization inhibitor, heating reflux reaction 8h, reaction after terminating, and has a large amount of white crystals to separate out, and suction filtration uses dichloro
Methane is recrystallized twice, and the air drying in vacuum drying oven is obtained methylacryoyloxyethyl-benzyl-dimethyl ammonium chloride list
Body, as doped quaternary ammonium salt monomer；
S2, medical absorbent cotton gauze irradiation grafting：12g medical absorbent cottons gauze, step S1 is added to obtain in the conical flask of 250ml
The doped quaternary ammonium salt monomer and 100ml deionized waters for arriving, the wherein mass ratio of medical absorbent cotton gauze and doped quaternary ammonium salt monomer are 2：1, nitrogen
Gas bell 30min, sealing, uses Co60Gamma-ray irradiation is grafted, and the time of irradiation grafting is 60min, after graft reaction terminates, uses
Acetone washs medical absorbent cotton gauze, then extracts 12h, dries, and obtains final product antibacterial hemostatic gauze.
For whether antibacterial hemostatic gauze prepared by the checking present invention reaches expected invention effect, prepared by embodiment 1 ~ 3
Antibacterial hemostatic gauze carry out antibacterial experiment, as a result as shown in table 1.
The antibacterial tests result table of table 1
As it can be seen from table 1 compared with common medical absorbent cotton gauze, by prepared by preparation method disclosed by the invention resisting
Bacterium hemostatic gauze has excellent anti-microbial property.
For whether antibacterial hemostatic gauze prepared by the checking present invention reaches expected invention effect, prepared by embodiment 1 ~ 3
Antibacterial hemostatic gauze carry out external clotting assay, as a result as shown in table 2.
The external thrombotest result table of table 2
From table 2 it can be seen that compared with common medical absorbent cotton gauze, by prepared by preparation method disclosed by the invention resisting
Bacterium hemostatic gauze substantially shortens the clotting time, and antibacterial hemostatic gauze prepared by the present invention has excellent anthemorrhagic performance.
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not right
The restriction of embodiments of the present invention；For those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms, there is no need and unable to be exhaustive to all of implementation method；It is all this
Any modification, equivalent and improvement made within the spirit and principle of invention etc., should be included in the claims in the present invention
Protection domain within.
Claims (6)
1. a kind of preparation method of antibacterial hemostatic gauze, it is characterised in that the preparation method is comprised the following steps that：
The preparation of S1, doped quaternary ammonium salt monomer：With dichloromethane as solvent, 200ml dichloromethane is added in single port bottle, in mass ratio
It is 2.5：1~1：1.5 add methacrylic acid 2-（N, N- dimethyl amido）Ethyl ester and benzyl chloride, add hydroquinones conduct
Polymerization inhibitor, heating reflux reaction, reaction is cooled down after terminating, and has a large amount of white crystals to separate out, suction filtration, with recrystallize with dichloromethane two
Secondary, the air drying in vacuum drying oven is obtained methylacryoyloxyethyl-benzyl-dimethyl ammonium chloride monomer, as doped quaternary ammonium salt
Monomer；
S2, medical absorbent cotton gauze irradiation grafting：Medical absorbent cotton gauze, step S1 is added to obtain in the conical flask of 250ml
Doped quaternary ammonium salt monomer and 100ml deionized waters, nitrogen bubble 10min ~ 30min, sealing, use Co60Gamma-ray irradiation is grafted, and connects
After branch reaction terminates, medical absorbent cotton gauze is washed with acetone, then extract 12h, dried, obtain final product antibacterial hemostatic gauze.
2. the preparation method of a kind of antibacterial hemostatic gauze according to claim 1, it is characterised in that in described step S1
Methacrylic acid 2-（N, N- dimethyl amido）The addition of ethyl ester is 10g ~ 20g, the addition of hydroquinones for 0.5g ~
1.0g。
3. the preparation method of a kind of antibacterial hemostatic gauze according to claim 1, it is characterised in that in described step S1
The time of heating reflux reaction is 5h ~ 8h.
4. the preparation method of a kind of antibacterial hemostatic gauze according to claim 1, it is characterised in that in described step S2
Medical absorbent cotton gauze is 1 with the mass ratio of doped quaternary ammonium salt monomer：2~2：1, the addition of medical absorbent cotton gauze is 10g ~ 12g.
5. the preparation method of a kind of antibacterial hemostatic gauze according to claim 1, it is characterised in that in described step S2
Co60The time of gamma-ray irradiation grafting is 30min ~ 60min.
6. a kind of antibacterial hemostatic gauze, it is characterised in that described antibacterial hemostatic gauze is as described in claim any one of 1-5
The preparation method of antibacterial hemostatic gauze is prepared.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331573A (en) * | 2019-06-12 | 2019-10-15 | 安徽启威生物科技有限公司 | A kind of preparation method of the antibiotic fabric based on gamma-ray irradiation crosslinking technology |
| CN116515021A (en) * | 2023-05-19 | 2023-08-01 | 广东省科学院化工研究所 | Poly (N, N-dialkylaminoethyl) methacrylate quaternary ammonium salt, and preparation method and application thereof |
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| CN1400355A (en) * | 2002-09-20 | 2003-03-05 | 清华大学 | Preparation method of macromolecular sterilization fibre with grafted antibacterial monomer on its surface |
| CN101717340A (en) * | 2009-12-10 | 2010-06-02 | 淮海工学院 | Method for cleanly producing high-purity (methyl) acryloyl ethoxy benzyldimethyl ammonium chloride |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331573A (en) * | 2019-06-12 | 2019-10-15 | 安徽启威生物科技有限公司 | A kind of preparation method of the antibiotic fabric based on gamma-ray irradiation crosslinking technology |
| CN116515021A (en) * | 2023-05-19 | 2023-08-01 | 广东省科学院化工研究所 | Poly (N, N-dialkylaminoethyl) methacrylate quaternary ammonium salt, and preparation method and application thereof |
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