CN106831466B - A kind of conventional storage method of Beta-alanine - Google Patents
A kind of conventional storage method of Beta-alanine Download PDFInfo
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- CN106831466B CN106831466B CN201611233073.0A CN201611233073A CN106831466B CN 106831466 B CN106831466 B CN 106831466B CN 201611233073 A CN201611233073 A CN 201611233073A CN 106831466 B CN106831466 B CN 106831466B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/44—Stabilisation; Use of additives
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A kind of conventional storage method of beta Alanine, is related to medicine intermediate processing technique field, by collect beta Alanine pretreatment after precooling, add stabilizer, auxiliary agent cooling refrigeration after, you can.Beneficial effects of the present invention are：Present invention determine that be conducive to the suitable condition of the storage of beta Alanine, rational temperature, humidity in storehouse when ensure that beta Alanine storage, solve the problems, such as that beta Alanine denaturation and activity during preserving decline, improve the storage time of beta Alanine, the actual performance of beta Alanine will not be destroyed, convenient for long storage.
Description
Technical field
The present invention relates to medicine intermediate processing technique fields, and in particular to a kind of conventional storage method of Beta-alanine.
Background technology
Beta-alanine, white prismatic crystallization are slightly sweet.Fusing point 205 DEG C (decomposition), relative density 1.437.It is dissolved in water, slightly soluble
In ethyl alcohol, insoluble in ether and acetone.At 25 DEG C, 100ml water dissolvables 55.5g.50% pH value of water solution 6.0-7.3.Its hydrogen
Chloride be white plates or leaflet crystal, 122.5 DEG C of fusing point.Its chlorination platinum salt is yellow platelet, and 210 DEG C of fusing point (divides
Solution), it is mainly used for electroplating corrosion inhibiter and biochemical reagents, the intermediate calcium pantothenate for being used to prepare the cold smoked plum of chloramphenicol, can be used for
After the researchs such as microbiology and biochemistry, Beta-alanine purposes is very extensive, but prepared by its processing, since it has itself
Specific, in storage, activity is easy to decline, and causes the performance of Beta-alanine to have certain variation, loses its original activity,
Influence its actual using effect.
The content of the invention：
The technical problems to be solved by the invention are to provide a kind of storage method scientific system, guarantee Beta-alanine activity
The conventional storage method of constant Beta-alanine.
The technical problems to be solved by the invention are realized using following technical scheme：
A kind of conventional storage method of Beta-alanine, which is characterized in that comprise the following steps：
1., collect or newly configure Beta-alanine, the Beta-alanine of collection is no more than 15h, and Beta-alanine must be pure
Without remaining impurity；
2., the Beta-alanine of above-mentioned collection be subjected to preliminary freezing obtain freeze-dried powder, then place it in freezer, adjust
It is 4-5 DEG C to save temperature in freezer, low temperature precooling 15-20min；
3., the Beta-alanine after above-mentioned low temperature precooling taken out, in temperature in the environment between 0-10 DEG C, to be put into an appearance
In device, then the glycerine of mixing addition wherein, is stirred uniformly mixed, static 20-30min；
4., above-mentioned steps 3 mixed to the Beta-alanine after glycerine be placed again into freezer, then cool the temperature to 4-5 again
DEG C, constant temperature precooling 5-7min；
5., the Beta-alanine after 4 precooling of above-mentioned steps is sealed, be then -20-10 by temperature control in freezer
DEG C, constant refrigeration 20-30min again；
6. it is -80 DEG C by temperature control in freezer after treating that above-mentioned steps 5 refrigerate, it is lasting to refrigerate, until in use,
It takes out；
7. adjusting oxygen content in freezer in step 6 to 2%-4%, carbon dioxide content is adjusted to 2%-10%, wet
Degree control is in 15-25%；
The concentration of glycerine in above-mentioned steps 3 is 20-50%；
Beneficial effects of the present invention are：Present invention determine that being conducive to the suitable condition of the storage of Beta-alanine, ensure that
Rational temperature, humidity in storehouse when Beta-alanine stores, solve Beta-alanine denaturation and activity during preserving and decline
The problem of, the storage time of Beta-alanine is improved, the actual performance of Beta-alanine will not be destroyed, convenient for long storage.
Specific embodiment
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
A kind of conventional storage method of Beta-alanine, comprises the following steps：
1., collect or newly configure Beta-alanine, the Beta-alanine of collection is no more than 15h, and Beta-alanine must be pure
Without remaining impurity；
2., the Beta-alanine of above-mentioned collection be subjected to preliminary freezing obtain freeze-dried powder, then place it in freezer, adjust
It is 4 DEG C to save temperature in freezer, low temperature precooling 15min；
3., the Beta-alanine after above-mentioned low temperature precooling taken out, in temperature in the environment between 0 DEG C, to be put into a container
In, then the glycerine of mixing addition wherein, is stirred uniformly mixed, static 20min；
4., above-mentioned steps 3 mixed to the Beta-alanine after glycerine be placed again into freezer, then cool the temperature to 4 DEG C again,
Constant temperature precooling 5min；
5., the Beta-alanine after 4 precooling of above-mentioned steps is sealed, be then -20 DEG C by temperature control in freezer, then
Secondary constant refrigeration 20min；
6., treat that above-mentioned steps 5 refrigerate after, temperature control in freezer is lasting to refrigerate for -80 DEG C, until in use,
It takes out；
7. adjusting oxygen content in freezer in step 6 to 2%, carbon dioxide content is adjusted to 2%, and humid control exists
15%；
Embodiment 2
A kind of conventional storage method of Beta-alanine, comprises the following steps：
1., collect or newly configure Beta-alanine, the Beta-alanine of collection is no more than 15h, and Beta-alanine must be pure
Without remaining impurity；
2., the Beta-alanine of above-mentioned collection be subjected to preliminary freezing obtain freeze-dried powder, then place it in freezer, adjust
It is 5 DEG C to save temperature in freezer, low temperature precooling 20min；
3., the Beta-alanine after above-mentioned low temperature precooling taken out, in temperature in the environment between 10 DEG C, to be put into a container
In, then the glycerine of mixing addition wherein, is stirred uniformly mixed, static 30min；
4., above-mentioned steps 3 mixed to the Beta-alanine after glycerine be placed again into freezer, then cool the temperature to 5 DEG C again,
Constant temperature precooling 7min；
5., the Beta-alanine after 4 precooling of above-mentioned steps is sealed, be then 10 DEG C by temperature control in freezer, then
Secondary constant refrigeration 30min；
6., treat that above-mentioned steps 5 refrigerate after, temperature control in freezer is lasting to refrigerate for -80 DEG C, until in use,
It takes out；
7. adjusting oxygen content in freezer in step 6 to 4%, carbon dioxide content is adjusted to 10%, and humid control exists
25%；
The basic principles, main features and the advantages of the invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (2)
1. a kind of conventional storage method of Beta-alanine, which is characterized in that comprise the following steps：
1., collect or newly configure Beta-alanine, the Beta-alanine of collection is no more than 15h, and Beta-alanine must be pure without remaining
Impurity；
2., the Beta-alanine of above-mentioned collection be subjected to preliminary freezing obtain freeze-dried powder, then place it in freezer, adjust cold
Temperature is 4-5 DEG C in storehouse, low temperature precooling 15-20min；
3., the Beta-alanine after above-mentioned low temperature precooling taken out, in temperature in the environment between 0-10 DEG C, to be put into a container
In, then the glycerine of mixing addition wherein, is stirred uniformly mixed, static 20-30min；
4., above-mentioned steps 3 mixed to the Beta-alanine after glycerine be placed again into freezer, then cool the temperature to 4-5 DEG C again, it is permanent
Warm precooling 5-7min；
5., the Beta-alanine after 4 precooling of above-mentioned steps is sealed, be then -20-10 DEG C by temperature control in freezer, then
Secondary constant refrigeration 20-30min；
6., treat that above-mentioned steps 5 refrigerate after, temperature control in freezer is lasting to refrigerate for -80 DEG C, until in use, taking
Go out；
7., oxygen content in freezer in step 6 adjusted to 2%-4%, carbon dioxide content is adjusted to 2%-10%, humidity control
System is in 15-25%.
2. a kind of conventional storage method of Beta-alanine according to claim 1, it is characterised in that：In the step 3
The concentration of glycerine is 20-50%.
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| CN201611233073.0A CN106831466B (en) | 2016-12-28 | 2016-12-28 | A kind of conventional storage method of Beta-alanine |
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| CN201611233073.0A CN106831466B (en) | 2016-12-28 | 2016-12-28 | A kind of conventional storage method of Beta-alanine |
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| CN106831466A CN106831466A (en) | 2017-06-13 |
| CN106831466B true CN106831466B (en) | 2018-05-22 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173487A (en) * | 1996-10-08 | 1998-02-18 | 马子鳌 | Method for extracting amino acid needed by human body and amino acid products series |
| CN1205628A (en) * | 1995-10-25 | 1999-01-20 | 曼海姆泊灵格股份公司 | Method and prepns. for stabilizing biological materials by drying methods without freezing |
| WO2007061529A1 (en) * | 2005-11-18 | 2007-05-31 | Scidose Llc. | Lyophilization process and products obtained thereby |
| CN101100437A (en) * | 2007-08-15 | 2008-01-09 | 安徽天润得生物工程有限公司 | Method for preparing high-purity beta-alanine |
| WO2011127039A1 (en) * | 2010-04-05 | 2011-10-13 | Abbott Laboratories | Shelf stable nutritional liquids comprising beta alanine |
| PL2175975T3 (en) * | 2007-07-03 | 2012-11-30 | Basf Se | Process for producing a free-flowing and storage-stable solid comprising essentially alpha-alanine-n,n-diacetic acid and/or one or more derivatives of alpha-alanine-n,n-diacetic acid |
-
2016
- 2016-12-28 CN CN201611233073.0A patent/CN106831466B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205628A (en) * | 1995-10-25 | 1999-01-20 | 曼海姆泊灵格股份公司 | Method and prepns. for stabilizing biological materials by drying methods without freezing |
| CN1173487A (en) * | 1996-10-08 | 1998-02-18 | 马子鳌 | Method for extracting amino acid needed by human body and amino acid products series |
| WO2007061529A1 (en) * | 2005-11-18 | 2007-05-31 | Scidose Llc. | Lyophilization process and products obtained thereby |
| PL2175975T3 (en) * | 2007-07-03 | 2012-11-30 | Basf Se | Process for producing a free-flowing and storage-stable solid comprising essentially alpha-alanine-n,n-diacetic acid and/or one or more derivatives of alpha-alanine-n,n-diacetic acid |
| CN101100437A (en) * | 2007-08-15 | 2008-01-09 | 安徽天润得生物工程有限公司 | Method for preparing high-purity beta-alanine |
| WO2011127039A1 (en) * | 2010-04-05 | 2011-10-13 | Abbott Laboratories | Shelf stable nutritional liquids comprising beta alanine |
Non-Patent Citations (1)
| Title |
|---|
| 从骨胶中制备L-羟脯氨酸的研究;吕红线;《山东轻工业学院学报》;19971231;第11卷(第4期);第53-56页 * |
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| CN106831466A (en) | 2017-06-13 |
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Effective date of registration: 20191129 Address after: 264200 Beihai building, sunjiatuan street, Huancui District, Weihai City, Shandong Province 427 Patentee after: Weihai Haitai Biotechnology Co.,Ltd. Address before: 233700 Guzhen Economic Development Zone, Bengbu, Anhui Patentee before: ANHUI HONGSHENG BIOLOGICAL CO.,LTD. |
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Address after: Room 405-6, Building 5, Software Park, 78 Keling Road, High-tech Zone, Suzhou, Jiangsu Province, 215000 Patentee after: Suzhou Haitai Meibo Biotechnology Co.,Ltd. Address before: 427 Beihai Building, Sunjiatuan Street, Huancui District, Weihai City, Shandong Province, 264200 Patentee before: Weihai Haitai Biotechnology Co.,Ltd. |