CN106825110B - A kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing - Google Patents
A kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing Download PDFInfo
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- CN106825110B CN106825110B CN201710159395.3A CN201710159395A CN106825110B CN 106825110 B CN106825110 B CN 106825110B CN 201710159395 A CN201710159395 A CN 201710159395A CN 106825110 B CN106825110 B CN 106825110B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
- B21C—MANUFACTURE OF METAL SHEETS, WIRE, RODS, TUBES OR PROFILES, OTHERWISE THAN BY ROLLING; AUXILIARY OPERATIONS USED IN CONNECTION WITH METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL
- B21C37/00—Manufacture of metal sheets, bars, wire, tubes or like semi-manufactured products, not otherwise provided for; Manufacture of tubes of special shape
- B21C37/06—Manufacture of metal sheets, bars, wire, tubes or like semi-manufactured products, not otherwise provided for; Manufacture of tubes of special shape of tubes or metal hoses; Combined procedures for making tubes, e.g. for making multi-wall tubes
- B21C37/15—Making tubes of special shape; Making tube fittings
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Abstract
The present invention discloses a kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing, and steps are as follows：Under the premise of without Overheating Treatment, in extrusion ratio 50 200, mold is preheating in the case of 200 DEG C 400 DEG C, hot extrusion processing is directly carried out to cost zinc alloy blank, obtain the tube billet that outer diameter is 2.0 mm, 3.50 mm, wall thickness is 0.20 mm, 0.35 mm, then tube reducing is carried out using continuous cold drawing processing technology to pipe and subtracts wall processing, the thin footpath thin-walled capillary tubing that produce outer diameter be 1.50mm 2.80mm, wall thickness is 0.05mm 0.20mm.Processing method of the present invention is at low cost, and processing capillary tubes dimensional accuracy is high, and glacing flatness is high, and pipe thickness scale error is within 10 μm；Gained intravascular stent kirsite thin footpath thin-walled capillary tubing even tissue is prepared, corrosion is uniform；The elongation percentage of capillary tubes is 15% or more, tensile strength 210MPa 300MPa, excellent performance.
Description
Technical field
The invention belongs to metal material manufacturing method technical fields, and in particular to a kind of blood vessel for medical device industry
The method for processing forming of holder kirsite thin footpath thin-walled capillary tubing.
Background technology
Today's society, angiocardiopathy have been one of the main reason for leading to human death.According to the World Health Organization, it is expected that
By 2030, every year because the number for suffering from angiocardiopathy death will reach 23,600,000.In recent years, interventional medicine engineering instrument
Industry is grown rapidly, and manufacturing technology has significant progress, to solve the limitation of conventional metals holder, biological degradable in vivo
Absorbing material is just becoming the emphasis of research and development, which can support tube chamber within a certain period of time after implanting, keep
Unobstructed blood vessel can gradually degrade to disappearance after completing pathological effect, to effectively prevent the acute occlusion after blood vessel dilatation
And restenosis.
Zinc is one of micro elements needed by human, all physiological metabolism processes is participated in body, zinc is in addition in a variety of gold
Belong to and being played in enzyme, transcription factor and other albumen outside catalysis or structure effect, is played also in the form of neurotransmitter or quenched sample
Its function.Key, which is zinc, can also quickly enter endothelial cell, maintain the integrality of endothelial cell, reduce blood vessel to Atherosclerosis
The neurological susceptibility of change.Zinc-containing alloy compared to have for polylactic acid excellent mechanical property and can developability, while having good
Biocompatibility；Compared with magnesium, metallic zinc and its alloy not only have good biocompatibility, and since its is higher
Corrosion potential, thus degradation property is better than magnesium base alloy；The degradation rate of zinc-containing alloy is faster than polylactic acid degradation, compares magnesium alloy
Degradation is slow, and degradation rate is more adapted to the reconstruction of blood vessel, is more in line with the demand of clinical intervention treatment, is expected to develop into
New bio medical degradable vascular stent material.
Currently, high-precision thin footpath capillary tubes are the very extensive medical device materials of purposes, it is the various branch of production and processing
The core material of frame product and other related equipment products, therefore degradable zinc alloy metal tubing is developed with important practicality
Value and scientific meaning.Due to the close-packed hexagonal structure and its poor mechanical property of zinc, the processing of kirsite thin-walled thin footpath micro-pipe
Technique is always a difficult point, and the capillary tubes limited length of preparation, wall unevenness are even, glacing flatness is poor, and performance is low, it is extremely difficult to
By the coronary artery bracket for being laser-cut into clinical medical.
Invention content
It is thin in view of the deficiencies of the prior art, the present invention intends to provide a kind of intravascular stent kirsite thin footpath
The method for processing forming of wall capillary tubes, the capillary size precision processed using this method is high, good straightness degree, thickness of pipe wall
Scale error is spent within 10 μm, and performance is good.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing comprising following steps：
1）Kirsite blank carries out extrusion process：Under the premise of without Overheating Treatment, in extrusion ratio 50-200, mold is pre-
Heat directly carries out hot extrusion processing in the case of 200 DEG C -400 DEG C to cost zinc alloy blank；
2）The rate of extrusion of capillary tubes：Pass through hot extrusion（The initial extrusion rates of capillary tubes are 15 cm/s-20
Cm/s, then blank constantly harden, rate of extrusion be gradually decrease to 1mm/s-8mm/s keep stablize）Processing obtains outer diameter and is
2.0mm-3.50mm, the capillary tubes that wall thickness is 0.20mm-0.35mm, the capillary tubes after extruding are cooled to room in air
Temperature；
3）The heat treatment of capillary tubes：To capillary tubes after cooling in 100 DEG C of -150 DEG C of 20 min of annealing isothermal holding
- 30 min, recrystallization annealing make it easy to follow-up drawing processing to eliminate processing hardening；
4）It is required according to the size of required capillary tubes, capillary tubes is carried out by the way of the continuous cold drawing of spindle-less
Tube reducing, single pass reduce 0.02 mm -0.12 mm of tube outer diameter, and tube outer diameter is 1.5mm-3.0mm after tube reducing；
5）To step 4）Obtained tubing carries out subtracting wall using centering spindle's drawing process is machined to required specification；
Described subtracts wall processing, and single pass reduces 0.02 mm -0.1 mm of wall thickness, and the axle diameter used is 1.2 mm -2.6 mm；
Final gained capillary tubes outer diameter is 1.4mm-2.8mm, and wall thickness 0.05mm-0.20mm, pipe thickness scale error is at 10 μm
Within.
Specifically, step 1）Described in cost zinc alloy be preferably Zn-Mg alloys, Zn-Ca alloys, Zn-Sr alloys, Zn-
One kind in Mg-Nd alloys, Zn-Mg-Mn alloys, Zn-Mg-Ca alloys, Zn-Mg-Y-Nd alloys.Above-mentioned alloy product can be according to
This field conventional method or the melting of commission factory prepare.
This method is broken through the limitation of existing processing technology, is successfully prepared by heat treatment, large extrusion ratio and drawing process
Intravascular stent kirsite thin footpath thin-walled capillary tubing with excellent performance.Processing method of the present invention has the following advantages that：At
This is low, and processing capillary tubes dimensional accuracy is high, and glacing flatness is high, and pipe thickness scale error is within 10 μm；Even tissue, it is rotten
Erosion is uniform；The elongation percentage of capillary tubes is 15% or more, 210 MPa-300MPa of tensile strength.
Description of the drawings
Fig. 1 is the design and installation signal of extrusion die operating diagram and the aligning pipe with pedestal in the method for the present invention
Figure；
Fig. 2 is the drawing machining sketch chart of capillary tubes in the method for the present invention；
Fig. 3 is in the method for the present invention from extrusion billet to thin footpath thin-walled capillary tubing and the cross of thin footpath thin-walled capillary tubing
Macroscopical schematic diagram in section.
Specific implementation mode
Below in conjunction with specific embodiment, invention is further described in detail, but technical scheme of the present invention is not limited to
In this.
Embodiment 1:
A kind of method for processing forming of intravascular stent Zn-Mg-Nd alloy thin footpath thin-walled capillary tubing comprising following step
Suddenly：
1）A diameter of 19mm, the extruded stock of high 11mm is made with wire cutting method in the as cast condition blank of Zn-Mg-Nd alloys
Material, after its surface scale is removed in turning, the holes 4mm are bored in centre（As shown in Figure 1）.Add an alignment at capillary outlet in the base
Pipe, the internal diameter of aligning pipe are identical as the outer diameter of the capillary tubes of extrusion；
2）By extrusion billet be put into extrusion cylinder interior diameter be 20mm mold in extrusion forming, 280 DEG C of mold preheating temperature,
Extrusion ratio 115 squeezes 280 DEG C of temperature；The initial extrusion rates of capillary tubes are 20cm/s.Gained capillary tubes are placed after extruding
It is cooled to room temperature in air, outer diameter 2.8mm, wall thickness 0.3mm, the length of capillary tubes is 800mm；It is used when extruding
Device vertically offers in the extrusion cylinder at center as shown in Figure 1, including pedestal and the extrusion cylinder on pedestal
To place the first through hole of mold, the mold includes the extruding punch being located above and underlying Extruding die, and
Mold is slided up and down with extrusion cylinder and is connect；The second through-hole is vertically offered at the base center, is set in the second through-hole
There are aligning pipe, alignment bore identical as the capillary tubes outer diameter of extrusion；The longitudinal center line of the first through hole and second leads to
The longitudinal center line in hole coincides；
3）By step 2）Gained squeezes postcapillary material in 120 DEG C of annealing isothermal holding 30min, then spindle-less is used to connect
The mode of continuous cold drawing starts drawing tube reducing, directly carries out the continuous cold drawing processing of multi-pass, and single pass reduces outer diameter
0.1mm, until outer diameter uses centering spindle's drawing process after reducing to 2.5mm（As shown in Figure 2）It carries out subtracting wall processing, single pass reduces
Wall thickness 0.025mm, the axle diameter used is 2.2mm, until required specification 2.4mm, wall thickness 0.1mm（Such as Fig. 3 institutes
Show）.
The tensile strength 240MPa of above-mentioned gained thin footpath thin-walled capillary tubing is measured according to GBT 228.1-2010, is surrendered by force
Spend 150MPa, elongation percentage 19%.
Embodiment 2:
A kind of method for processing forming of intravascular stent Zn-Mg-Y-Nd alloy thin footpath thin-walled capillary tubing comprising as follows
Step：
1）A diameter of 14.5mm, the extruding of high 11mm is made with wire cutting method in the as cast condition blank of Zn-Mg-Y-Nd alloys
Blank, turning go its surface scale, centre to bore the holes 3mm.Add an aligning pipe at capillary outlet in the base, internal diameter with
The outer diameter of the capillary tubes of extrusion is identical；
2）By extrusion billet be put into extrusion cylinder interior diameter be 15mm mold in extrusion forming, 270 DEG C of mold preheating temperature,
Extrusion ratio 114 squeezes 270 DEG C of temperature；The initial extrusion rates of capillary tubes are 10cm/s.Gained capillary tubes are placed after extruding
It is cooled to room temperature in air, outer diameter 2.4mm, wall thickness 0.2mm, the length of capillary tubes is 1000mm；
3）By step 2）Gained squeezes postcapillary material in 120 DEG C of annealing isothermal holding 20min, then spindle-less is used to connect
The mode of continuous cold drawing starts drawing tube reducing, directly carries out the continuous cold drawing processing of multi-pass, and single pass reduces outer diameter
0.05mm, until outer diameter carries out subtracting wall processing using centering spindle's drawing process after reducing to 2.2mm, single pass reduces wall thickness
0..02mm, the axle diameter used is 1.8mm, until required specification 2.0mm, wall thickness 0.1mm.
The tensile strength 260MPa of above-mentioned gained thin footpath thin-walled capillary tubing is measured according to GBT 228.1-2010, is surrendered by force
Spend 170MPa, elongation percentage 16%.
Embodiment 3:
A kind of method for processing forming of intravascular stent Zn-Mg-Nd alloy thin footpath thin-walled capillary tubing comprising following step
Suddenly：
1）A diameter of 14.5mm, the extruded stock of high 12mm is made with wire cutting method in the as cast condition blank of Zn-Mg-Nd alloys
Material, after its surface scale is removed in turning, 3mm holes are bored in centre, add an aligning pipe at capillary outlet in the base, internal diameter with
The outer diameter for squeezing out capillary tubes is identical；
2）By extrusion billet be put into extrusion cylinder interior diameter be 15mm mold in extrusion forming, 250 DEG C of mold preheating temperature,
Extrusion ratio 96.75 squeezes 250 DEG C of temperature；The initial extrusion rates of capillary tubes are 10cm/s.Gained capillary tubes are put after extruding
It sets and is being cooled to room temperature in air, the length of outer diameter 2.8mm, wall thickness 0.2mm, capillary tubes are 1100mm；
3）By step 2）Gained squeezes postcapillary material and anneals in 120 DEG C isothermal holding 30min, then spindle-less continuous cold
The mode of drawing starts drawing tube reducing, directly carries out the continuous cold drawing processing of multi-pass, and single pass reduces outer diameter 0.1mm, waits for
Subtract wall processing using centering spindle's drawing process after reducing to 2.5mm to outer diameter, single pass reduces wall thickness 0.05mm, the core of use
Shaft diameter is 2.2mm, until required specification 2.4mm, wall thickness 0.1mm.
The tensile strength 265MPa of above-mentioned gained thin footpath thin-walled capillary tubing is measured according to GBT 228.1-2010, is surrendered by force
Spend 150MPa, elongation percentage 17.5%.
Claims (2)
1. a kind of intravascular stent method for processing forming of kirsite thin footpath thin-walled capillary tubing, which is characterized in that including as follows
Step：
1）Kirsite blank carries out extrusion process：Under the premise of without Overheating Treatment, in extrusion ratio 50-200, mold is preheating to
In the case of 200 DEG C -400 DEG C, hot extrusion processing is directly carried out to cost zinc alloy blank；
2）The rate of extrusion of capillary tubes：By hot extrusion process to obtain outer diameter be 2.0mm-3.50mm, wall thickness 0.20mm-
The capillary tubes of 0.35mm, the capillary tubes after extruding are cooled to room temperature in air；Wherein, the initial extrusion speed of capillary tubes
Rate is 15 cm/s-20 cm/s, and then blank constantly hardens, and rate of extrusion is gradually decrease to 1mm/s-8mm/s and keeps stablizing；
3）The heat treatment of capillary tubes：To capillary tubes after cooling in 100 DEG C of -150 DEG C of annealing isothermal holding 20-30
min；
4）It is required according to the size of required capillary tubes, capillary tubes is subtracted by the way of the continuous cold drawing of spindle-less
Diameter, single pass reduce tube outer diameter 0.02-0.12 mm, and tube outer diameter is 1.5mm-3.0mm after tube reducing；
5）To step 4）Obtained tubing carries out subtracting wall using centering spindle's drawing process is machined to required specification；It is described
Subtract wall processing, single pass reduce wall thickness 0.02-0.1 mm, the axle diameter used is 1.2-2.6 mm；Final gained capillary
Tube outer diameter is 1.4mm-2.8mm, and wall thickness 0.05mm-0.20mm, pipe thickness scale error is within 10 μm.
2. the intravascular stent according to claim 1 method for processing forming of kirsite thin footpath thin-walled capillary tubing, special
Sign is, step 1）Described in cost zinc alloy be Zn-Mg alloys, Zn-Ca alloys, Zn-Sr alloys, Zn-Mg-Nd alloys, Zn-
One kind in Mg-Mn alloys, Zn-Mg-Ca alloys, Zn-Mg-Y-Nd alloys.
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| CN201710159395.3A CN106825110B (en) | 2017-03-17 | 2017-03-17 | A kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing |
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| CN201710159395.3A CN106825110B (en) | 2017-03-17 | 2017-03-17 | A kind of method for processing forming of intravascular stent kirsite thin footpath thin-walled capillary tubing |
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| CN109433841B (en) * | 2018-11-07 | 2021-01-12 | 郑州大学 | Method for preparing superfine crystal magnesium alloy microtube for intravascular stent |
| CN111014329B (en) * | 2019-12-13 | 2021-09-28 | 广东华昌集团有限公司 | Gapless extrusion method for aluminum alloy seamless pipe |
| CN114130851A (en) * | 2020-09-04 | 2022-03-04 | 上海交通大学 | Preparation method of degradable magnesium alloy capillary tube for intravascular stent |
| CN113305166B (en) * | 2021-04-10 | 2022-09-27 | 桂林理工大学 | Diameter-expanding hot extrusion process for bimetal alloy steel composite pipe |
| CN113172106A (en) * | 2021-05-12 | 2021-07-27 | 天津冶金集团天材科技发展有限公司 | Die-overlapping drawing process of nickel-based superalloy small-diameter thin-wall seamless tube |
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| DE102005018356B4 (en) * | 2005-04-20 | 2010-02-25 | Eurocor Gmbh | Resorbable implants |
| CN102463271B (en) * | 2010-11-08 | 2014-01-08 | 北京有色金属研究总院 | Production method of zinc base alloy thin-wall pipe |
| CN103157692B (en) * | 2011-12-09 | 2015-06-10 | 北京有色金属研究总院 | Preparation method for zinc-based alloy specially-shaped tube |
| CN103667792B (en) * | 2013-12-18 | 2015-06-17 | 福州博德新材料科技有限公司 | Zinc aluminum based alloy extruded tube for delay element of industrial delay detonator and preparation method of zinc aluminum based alloy extruded tube |
| CN105964716B (en) * | 2016-05-11 | 2020-10-16 | 郑州大学 | One-step forming processing method of magnesium alloy thin-walled capillary tube for intravascular stent |
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