CN103789711B - A kind of preparation method of medical bio degradable zinc alloy capillary tubes - Google Patents
A kind of preparation method of medical bio degradable zinc alloy capillary tubes Download PDFInfo
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- CN103789711B CN103789711B CN201410051207.1A CN201410051207A CN103789711B CN 103789711 B CN103789711 B CN 103789711B CN 201410051207 A CN201410051207 A CN 201410051207A CN 103789711 B CN103789711 B CN 103789711B
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Abstract
The present invention relates to the preparation method of a kind of biological green wood section technical field, be specifically related to a kind of preparation method of medical bio degradable zinc alloy intravascular stent capillary tubes.The present invention is by the zinc alloy φ 25mm-φ 28mm bar of as cast condition, first through Overheating Treatment; Carrying out some passages to the bar after thermal treatment again swages to φ 12mm-φ 18mm; Bar after swaging is drilled to the zinc alloy tubing of tubulose; Again zinc alloy tubing is carried out some passes to external diameter φ 1.5mm-φ 3.0mm, the thin tubule material reaching φ 0.12mm-φ 0.16mm of wall; Finally by above-mentioned tubule material more as required drawing be described zinc alloy capillary tubes.The biological medical degradable zinc alloy capillary tubes made by the present invention: meet cutting clinical biochemical degradable blood vessel bracket, to over-all properties and degradation rate and mechanical support requirement, and excellent property.
Description
Technical field
The present invention relates to the preparation method of a kind of biological green wood section technical field, be specifically related to a kind of preparation method of medical bio degradable zinc alloy intravascular stent capillary tubes.
Background technology
A kind of medical bio degradable zinc alloy of the present invention is a kind of novel material, and this zinc alloy belongs to a kind of inductile alloy material, and drawing crack, tensile phenomenon easily appear in working method to adopt traditional stretching, roller draws etc.This two to tensile stress, and the alloy processing good to plasticity is favourable, and unfavorable to this type of inductile material zinc alloy, and the capillary tubes comprehensive mechanical property that drawing goes out is poor, and surface quality is bad, cannot meet medical requirement.
Summary of the invention
Object of the present invention aims to provide a kind of for the above-mentioned situation that inductile material not easily stretches, roller draws, and uses a kind of swaging to add the combined machining method of rolling, can be made the zinc alloy capillary tubes meeting medical requirement by this working method.
A preparation method for medical bio degradable zinc alloy capillary tubes, this preparation method comprises the following steps:
(1) the zinc alloy φ 25mm-φ 28mm bar of as cast condition is got, first through Overheating Treatment;
(2) carrying out some passages to the bar after thermal treatment swages to φ 12mm-φ 18mm;
(3) bar after swaging is drilled to the zinc alloy tubing of tubulose;
(4) zinc alloy tubing is carried out some passes to external diameter φ 1.5mm-φ 3.0mm, the thin tubule material reaching 0.12mm-0.16mm of wall;
(5) by above-mentioned tubule material more as required drawing be described zinc alloy capillary tubes.
Preferably, the heat treated temperature described in step (1) is 340 DEG C, and the time is 12h, furnace cooling.
Or preferably, described step has carried out swaging of four-pass to bar in (2), and carries out anneal respectively after the second passage and four-pass complete.
Or more preferably, swage before carrying out, first the forging die part of swager is heated to 180 DEG C-200 DEG C.
Or preferably, in described step (4), the rolling of ten passages carried out to zinc alloy tubing and after the second passage, the 5th passage and the 8th passage complete, carry out anneal respectively.
Or more preferably, described step (2), the annealing described in (4), temperature is 200 DEG C-240 DEG C, time 40min-60min.
The present invention's Performance comparision adding the biological medical degradable zinc alloy capillary tubes that Rolling compund method is made of swaging is excellent: tensile strength can reach (Rm:340Mpa-390Mpa), yield strength can reach (Rp0.2:250Mpa-280Mpa), unit elongation (A) 20%-30%, its erosion rate in simulated body fluid is 0.20-0.27mm/year.Method provided by the invention can prepare the Biodegradable vascular scaffold meeting clinical requirement, can meet degradation rate and the mechanical support requirement of intravascular stent.
Embodiment
Embodiment one:
(1) get the Zinc alloy bar (external diameter 28mm × 200mm) of as cast condition, peel off crust with lathe, become the bar of external diameter 27mm.First through Overheating Treatment, heat treated temperature 340 DEG C, time 12h, furnace cooling;
(2) by about the mold heated to 180 DEG C of swaging in swager, put into the bar after above-mentioned thermal treatment and carry out four-pass and swage.First passage is swaged to external diameter 21mm, second passage is swaged to external diameter 17mm by external diameter 21mm, an anneal is carried out after this passage completes, 3rd passage is swaged to external diameter 14mm by external diameter 17mm, 4th passage is swaged to external diameter 12mm by external diameter 14mm, carries out an anneal again after this passage completes.Wherein annealing temperature is 200 DEG C, time 60min;
(3) bar after swaging is drilled to the zinc alloy tubing that internal diameter is 7mm tubulose as required;
(4) zinc alloy tubing is carried out ten passes and obtain tubule material.First passage is rolling to external diameter 10mm, and the second passage is rolling to external diameter 7.9mm by external diameter 10mm, carries out anneal after this passage completes, and the 3rd passage is rolling to external diameter 7mm by external diameter 7.9mm, and four-pass is rolling to external diameter 6.1mm by external diameter 7mm; 5th passage is rolling to external diameter 5.2mm by external diameter 6.1mm, carries out anneal after this passage completes, then carries out 3 passes to external diameter 4mm, carries out an anneal more subsequently, proceeds 2 roads and is rolling to external diameter 3mm, the thin tubule material for 0.15mm of wall.Wherein annealing temperature is 220 DEG C, time 55min;
(5) by above-mentioned tubule material more as required drawing be external diameter 2.5mm, the zinc alloy capillary tubes of the thin 0.16mm of wall;
(6) after testing, the performance of above-mentioned zinc alloy capillary tubes is: tensile strength Rm:380Mpa, yield strength Rp0.2:260Mpa, unit elongation (A) 28%, and the erosion rate in simulated body fluid is 0.21mm/year.
Embodiment two:
(1) get the Zinc alloy bar (external diameter 26mm × 200mm) of as cast condition, peel off crust with lathe, become the bar of external diameter 25mm.First through Overheating Treatment, thermal treatment temp 340 DEG C, annealing time 12h, furnace cooling;
(2) by about the mold heated to 180 DEG C of swaging in swager, put into the bar after above-mentioned anneal and carry out four-pass and swage.First passage is swaged to external diameter 20mm, second passage is swaged to external diameter 17mm by external diameter 20mm, an anneal is carried out after this passage completes, 3rd passage is swaged to external diameter 15mm by external diameter 17mm, 4th passage is swaged to external diameter 14mm by external diameter 15mm, carries out an anneal again after this passage completes.Wherein annealing temperature is 200 DEG C, time 40min;
(3) bar after swaging is drilled to the zinc alloy tubing that internal diameter is 7mm tubulose as required;
(4) zinc alloy tubing is carried out ten passes to external diameter 2.0mm, the thin tubule material reaching 0.16mm of wall.First passage is rolling to external diameter 12mm, and the second passage is rolling to external diameter 10mm by external diameter 12mm, carries out anneal after this passage completes, and the 3rd passage is rolling to external diameter 8.5mm by external diameter 10mm, and four-pass is rolling to external diameter 7mm by external diameter 8.5mm; 5th passage is rolling to external diameter 5.8mm by external diameter 7mm, carries out anneal after this passage completes, then carries out 3 passes to external diameter 2.6mm, carries out an anneal more subsequently, proceeds 2 roads and is rolling to external diameter 2.0mm, the thin tubule material for 0.16mm of wall.Wherein annealing temperature is 210 DEG C, time 48min;
(5) by above-mentioned tubule material more as required drawing be external diameter 1.8mm, the zinc alloy capillary tubes of the thin 0.13mm of wall;
(6) after testing, the performance of above-mentioned zinc alloy capillary tubes is: tensile strength Rm:350Mpa, yield strength Rp0.2:260Mpa, unit elongation (A) 25%, and the erosion rate in simulated body fluid is 0.23mm/year.
Claims (6)
1. a preparation method for medical bio degradable zinc alloy capillary tubes, is characterized in that this preparation method comprises the following steps:
(1) the zinc alloy φ 25mm-φ 28mm bar of as cast condition is got, first through Overheating Treatment;
(2) carrying out some passages to the bar after thermal treatment swages to φ 12mm-φ 18mm;
(3) bar after swaging is drilled to the zinc alloy tubing of tubulose;
(4) zinc alloy tubing is carried out some passes to external diameter φ 1.5mm-φ 3.0mm, the thin tubule material reaching 0.12mm-0.16mm of wall;
(5) by above-mentioned tubule material more as required drawing be described zinc alloy capillary tubes.
2. the preparation method of a kind of medical bio degradable zinc alloy capillary tubes as claimed in claim 1, it is characterized in that: the thermal treatment temp described in step (1) is 340 DEG C, the time is 12h, furnace cooling.
3. the preparation method of a kind of medical bio degradable zinc alloy capillary tubes as claimed in claim 1, is characterized in that: described step has carried out swaging of four-pass to bar in (2), and after the second passage and four-pass complete, carries out anneal respectively.
4. the preparation method of a kind of medical bio degradable zinc alloy capillary tubes as claimed in claim 3, is characterized in that: swage before carrying out, first the forging die part of swager is heated to 180 DEG C-200 DEG C.
5. the preparation method of a kind of medical bio degradable zinc alloy capillary tubes as claimed in claim 1, is characterized in that: carry out the rolling of ten passages to zinc alloy tubing in described step (4) and after the second passage, the 5th passage and the 8th passage complete, carry out anneal respectively.
6. the preparation method of medical bio degradable zinc alloy capillary tubes as described in claim 3 or 4 or 5, it is characterized in that: described step (2), the annealing described in (4), temperature is 200 DEG C-240 DEG C, time 40min-60min.
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104624713B (en) * | 2014-12-17 | 2016-08-10 | 北京有色金属研究总院 | A kind of preparation method of the seamless tubule of precise determination of titanium alloy thin-wall |
| CN104888282B (en) * | 2015-05-05 | 2017-11-24 | 乐普（北京）医疗器械股份有限公司 | A kind of degradable zinc-base micropore carried stent and preparation method thereof |
| CN104857570B (en) * | 2015-05-05 | 2017-03-29 | 乐普（北京）医疗器械股份有限公司 | A kind of degradable zinc-containing alloy support and preparation method thereof |
| CN106467942B (en) * | 2015-08-19 | 2018-04-17 | 上海交通大学 | Biodegradable medical pltine and its preparation method and application |
| CN105414426B (en) * | 2015-12-11 | 2017-07-04 | 西北有色金属研究院 | A kind of hot-swage method of kirsite small specification tube or bar |
| CN107838222B (en) * | 2016-09-18 | 2019-06-21 | 上海交通大学 | The preparation method and applications of biological medical degradable kirsite capillary tubes |
| CN106862298B (en) * | 2017-02-15 | 2018-08-24 | 西安爱德万思医疗科技有限公司 | A kind of preparation method of the degradable kirsite capillary silk material of medical bio |
| CN108637033A (en) * | 2018-04-13 | 2018-10-12 | 西安瑞鑫科金属材料有限责任公司 | A method of preparing titanium alloy capillary tubes |
| CN111215473B (en) * | 2018-11-23 | 2022-02-08 | 有研金属复材技术有限公司 | Preparation method of high-precision small-diameter thin-wall aluminum alloy pipe capable of flaring and bending |
| CN109797315B (en) * | 2019-03-01 | 2021-07-13 | 湖南华耀百奥医疗科技有限公司 | Medical degradable zinc-based composite material and preparation method and application thereof |
| CN113061792B (en) * | 2019-12-24 | 2022-04-05 | 南京达迈科技实业有限公司 | Low-temperature superconducting Nb-Ti alloy capillary tube and preparation method thereof |
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| DE102005018356B4 (en) * | 2005-04-20 | 2010-02-25 | Eurocor Gmbh | Resorbable implants |
| CN100434554C (en) * | 2005-12-07 | 2008-11-19 | 同济大学 | Zinc-aluminium alloy wire, and its manufacturing method and use |
| EP1835042A1 (en) * | 2006-03-18 | 2007-09-19 | Acrostak Corp. | Magnesium-based alloy with improved combination of mechanical and corrosion characteristics |
| CN101722209B (en) * | 2009-11-26 | 2011-04-20 | 于洋 | Preparation method of large slenderness ratio and high-toughness magnesium alloy capillary |
| CN103394545B (en) * | 2013-07-30 | 2015-09-16 | 沪创医疗科技（上海）有限公司 | The precision machining method of biodegradable magnesium alloy intravascular stent capillary |
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