CN106823048A - A kind of parenchymal viscera local chemotherapy system and application method - Google Patents
A kind of parenchymal viscera local chemotherapy system and application method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3659—Cannulae pertaining to extracorporeal circulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3615—Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1071—Liver; Hepar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1082—Kidney
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Abstract
It is an object of the invention to provide a kind for the treatment of malignant tumour, the high efficiency chemotherapy treatment system and application method for even avoiding whole body from having no toxic side effect are reduced, the technical scheme for being used is, a kind of parenchymal viscera local chemotherapy system, including：Doser and blood filter device, it is characterized in that：The doser includes arterial duct and infusion pump, and arterial duct distal end connects the bifurcated artery of tumour, other end connection infusion pump, the heavy dose of medicine of injection；The blood filter device includes three-cavity air bag ductus venosus, blood filter and hsempdiakysing systems, the three-cavity air bag ductus venosus includes the body and base that are connected, the body connects parenchymal viscera stream cardinal vein or inferior caval vein, the base connects blood filter, the air bag of the three-cavity air bag ductus venosus can be used for block venous blood stream, the blood with chemotherapeutics is flowed directly into blood filter from cardinal vein, flow back into again after absorption in vivo.
Description
Technical field
The present invention relates to medical instruments field, specifically a kind of parenchymal viscera local chemotherapy system and user
Method.
Background technology
In the prior art clinically to parenchymal viscera, such as liver, kidney tumour chemotherapeutic treatment it is very ripe, big portion
Point malignant tumour have a sensitive effective chemotherapeutics, but all of chemotherapeutics have to the tissue of whole body larger killing and
Toxic and side effect, especially influences huge to brain, lung, liver, kidney, nerve fiber, digestive system and reproductive system, cause it is many with
The tumour patient of other sources hair disease cannot receive chemotherapeutic treatment.
In chemotherapy process, existing cancer chemotherapy guide commonly uses 4-6 or the longer course for the treatment of to treat；Its
Chemical therapy toxic side effect and adverse reaction cumulative time are long, often ill by systemic chemotherapy to liver, renal damage and bone marrow suppression etc.
People is interrupted chemotherapy or even abandons chemotherapeutic treatment halfway because not being resistant to.Current clinically most of malignant tumours are all than later
Phase, because older or constitution is weak etc., factor cannot tolerate chemotherapeutic treatment to patient, cause to abandon chemotherapeutic regimen.
At present clinically extensively using interposing catheter technology chemotherapy, i.e. application catheter technology is inserted near malignant tumour
Main vasa vasorum in discharge chemotherapeutic drug therapy, although the chemotherapy concentration that can improve tumor by local relative reduces whole body
Chemotherapeutics in toxic and side effect, but internal organs still can be back to the overwhelming majority of whole body by venous return and lymphatic system
Organ and tissue, easily produce serious toxic and side effect to human body, cause systemic chemotherapy poisonous side effect of medicine, constantly cumulative weight,
Finally often also abandon chemotherapy because chemotherapeutics can not be tolerated.
The present country, in the world extensive utilization targeted drug treatment tumour, but because of the spy of antigen antibody binding sites
The variability of the opposite sex and autologous tumor cells, easily causes the consequence that chemotherapy is insensitive or even chemotherapy is invalid.Eight medicines according to statistics
Effective treatment crowd of thing constitute about total patient 25% or so (targeted drug is effective to EJR50%, and the EJR genes of the mankind
Sudden Changing Rate is also 50%) and medical expense is very huge, is very big burden for common patient.Current cancer doctor
Puzzlement not chemotherapeutics therapeutic effect it is bad, and because everyone is with the whole body toxic and side effect after chemotherapeutic treatment and resistance to
The property of medicine is different from, so there is very strict dosage to control when using chemotherapeutics, so now with various embolic chemotherapies
It is difficult to whole tumors destroyed cells, and needed in chemotherapy to resist whole body toxic and side effect while using chemotherapeutics
Some are used to also need to use the medicine of increasing leucocyte and red blood cell such as liver protections, shield stomach and antiemetic, later stage simultaneously, treatment is all
Phase is long, and medical expense is high.
Clinically it is badly in need of development a kind for the treatment of malignant tumour, reduces the high efficiency for even avoiding whole body from having no toxic side effect
Treat treatment system and application method.
The content of the invention
It is an object of the invention to provide a kind of parenchymal viscera local chemotherapy system and application method, for liver, kidney
Local chemotherapy, can with heavy dose of medication and effectively mitigate and even avoid systemic chemotherapy poisonous side effect of medicine.
The technical scheme adopted by the invention to solve the technical problem is that：
A kind of parenchymal viscera local chemotherapy system, including doser and blood filter device, the doser bag
Arterial duct and infusion pump are included, arterial duct distal end connection parenchymal viscera supplies the bifurcated artery of tumour, and other end connection is defeated
Liquid pump；The blood filter device includes three-cavity air bag ductus venosus, blood filter and hsempdiakysing systems, the three-cavity air bag
Ductus venosus includes the body and base that are connected, and the body connects parenchymal viscera stream cardinal vein or inferior caval vein, described
Base connects blood filter；
The body includes arterial, duct of Arantius, air bag and air bag connecting tube；Arterial and duct of Arantius cross section size
Identical, arterial is connected parenchymal viscera cardinal vein with duct of Arantius distal end, and the other end is connected on base；Air bag is coated on described
On body；Air bag connecting tube is connected with air bag, is located on the inboard wall of tube body of sucquet's canal separation, and the other end is connected on base；
The base includes pipe seat body, artery head, vein head and check valve, and the first end of artery connects arterial by pipe seat body, separately
One end connects blood filter, and the first end of vein connects duct of Arantius, other end connection blood filter, check valve by pipe seat body
One end connects air bag connecting tube, and the other end can connect syringe injection air；
A kind of application method of parenchymal viscera local chemotherapy system, comprises the following steps：
1) branch of the arterial duct distal end connection parenchymal viscera supply tumour of doser is moved through femoral arteriography
Arteries and veins；
2) percutaneous puncture imports in parenchymal viscera stream cardinal vein or inferior caval vein blood vessel three-cavity air bag ductus venosus, leads to
Cross parenchymal viscera stream cardinal vein or inferior caval vein sets up extracorporeal blood sorption cycle system；
3) blood filter is attached to hsempdiakysing systems, physiological saline preliminary filling connects the dynamic of three-cavity air bag ductus venosus
Arteries and veins end and vein end, start hsempdiakysing systems and start blood circulation；The check valve of pipe end is connected after stable circulation by air bag
Injection air makes air bag heave block venous blood stream, and extracorporeal blood sorption cycle system is set up and finished；
4) heavy dose of chemotherapeutics is injected at a predetermined velocity by the arterial duct and infusion pump of doser, is finished
Postheparin salt water sealing (sealing water) pipe；
5) treatment of Blood index is proceeded, chemotherapeutics is residual in detecting blood after being finished 1-4 hours to artery injection
Stay, detect that the air in air bag is discharged recovery venous blood stream by the qualified rear check valve for connecting pipe end by air bag
It is logical, seance is completed, three-cavity air bag ductus venosus uses heparin saline tube sealing；
6) after treatment starts, 60~80IU/kg of LMWHs is injected intravenously, prevents extracorporal circulatory system blood coagulation；
7) tube drawing by parenchyma continuously treats two to three times, once a day；
The step 4), 5) heparin concentration of heparin saline is 1000IU/ml；
The step 4) in heavy dose 3-7 times of chemotherapeutics dosage when being systemic chemotherapy, injection rate is that 5-30 divides
Clock.
The beneficial effects of the invention are as follows：
1. pair can not cut off or operation consent therapeutic alliance entity tumor provide can heavy dose use cytotoxic drug,
And can mitigate or even avoid whole body toxicity.
2. the duration of chemotherapy cycles drastically reduce the area, and the treatment cycle that classic chemotherapy takes 4-6 month can be only achieved
Therapeutic effect, the system only needs to two to three days can just be reached.
3. the use of chemotherapeutics and supporting nutrient drug drastically reduce the area, because the through focus of medicine, although be big
Dosage medication, but the medicine of half even 70% still can be saved compared to classic chemotherapy, the financial burden of patient is alleviated, subtract
Pollution of the medicine discharge to environment is lacked.
4. safe, coordinate peripheral blood monitor drug concentration further over much dosage can precisely treat.
Brief description of the drawings
Fig. 1 is parenchymal viscera local chemotherapy system and application method schematic diagram；
Fig. 2 is three-cavity air bag ductus venosus schematic diagram；
Fig. 3 is the profile of three-cavity air bag ductus venosus air bag unaerated；
Fig. 4 is profile after three-cavity air bag ductus venosus airbag aeration.
In figure：1 body, 101 arterials, 102 duct of Arantius, 103 air bag connecting tubes, 104 air bags, 105 arterial distal ends
Mouthful, 106 duct of Arantius remote ports, 107 airsac tube remote ports, 2 pipe seat bodies, 201 artery heads, 202 vein heads, 203 check valves,
3 hsempdiakysing systems, 4 blood filters, 5 arterial ducts, 6 infusion pumps, the bifurcated artery of 7 supply tumours, 8 tumours, 9 is substantive dirty
Device, 10 parenchymal viscera stream cardinal veins or inferior caval vein.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described.
Embodiment 1
As shown in figure 1, a kind of parenchymal viscera local chemotherapy system, including doser and blood filter device；Administration
Device includes arterial duct 5 and infusion pump 6, and the distal end of arterial duct 5 connection parenchymal viscera supplies the bifurcated artery 7 of tumour, separately
One end connects infusion pump 6；Blood filter device includes three-cavity air bag ductus venosus, hsempdiakysing systems 3 and blood filter 4, three
Chamber air bag ductus venosus includes body 1 and base 2, and body is connected with base, and body 1 connects the cardinal vein 10 of parenchymal viscera,
Base 2 connects blood filter 4；In practical operation, the bifurcated artery 7 of specific supply tumour can not be sometimes found,
At this moment the distal end of arterial duct 5 can be directly connected to position of the parenchymal viscera sustainer close proximity to tumour, can also plays identical
Effect.
As shown in figs 2-4, body 1 includes arterial 101, duct of Arantius 102, air bag connecting tube 103 and air bag 104,
Arterial 101 is identical with the cross section size of duct of Arantius 102, and it is quiet that arterial 101 is connected parenchymal viscera master with the distal end of duct of Arantius 102
Arteries and veins 10, the other end is connected on base 2, and air bag 104 is coated on the body 1, and air bag connecting tube 103 is located at the inwall of body 1
On, air bag connecting tube remote port 107 is connected with air bag 104, and the other end of airsac tube 103 is connected on base 2；Base includes pipe
Pedestal 2, artery first 201, vein first 202 and check valve 203, first 201 one end of artery connect arterial 101 by pipe seat body 2,
The other end connects blood filter 4, and first 202 one end of vein connects duct of Arantius 102, other end connection blood mistake by pipe seat body 2
Filter 4, one end of check valve 203 connects air bag connecting tube 103, other end connection syringe injection air.
Chemotherapeutics is injected by infusion pump 6, chemotherapeutics enters parenchymal viscera and supplies tumour by arterial duct 5
Bifurcated artery 7 is simultaneously nearby spread, and starts tumors destroyed cell, and the blood with chemotherapeutics is completed in parenchymal viscera 9
Parenchymal viscera cardinal vein 10 is flowed into after circulation, under the blocking effect of air bag 104, the blood with chemotherapeutics cannot be direct
Human circulation is flowed into, but flows into three-cavity air bag ductus venosus arterial 101, opened by the first 201 inflow blood filter 4 of artery
Begin to filter absorption, three-cavity air bag ductus venosus body flowed back to by vein first 202 by the blood after the purification of blood filter 4,
Then parenchymal viscera cardinal vein 10 is flow back into from the duct of Arantius remote port 106 of body, into human circulation.
Embodiment 2
Accordingly present invention also offers a kind of application method of parenchymal viscera local chemotherapy system, specifically include following
Step：
1) according to different parts parenchymal viscera tumour, can be through femoral arteriography by the distal end of arterial duct 5 of doser
It is connected to the bifurcated artery 7 that parenchymal viscera supplies tumour.
2) percutaneous puncture of three-cavity air bag ductus venosus body 1 is imported into parenchymal viscera stream cardinal vein or inferior caval vein blood vessel
Interior 10 outlet；
3) three-cavity air bag ductus venosus artery first 201 and vein first 202 are connected using blood filter 4, begins setting up body
The circulation of outer Blood index, after stable circulation by check valve 203 inject air heave air bag 104 to block parenchymal viscera master quiet
Arteries and veins blood flow, extracorporeal blood sorption cycle system is set up and is finished；
4) HDC medicine (using 3 times of systemic chemotherapy dosage) injection is injected by the infusion pump 6 of doser
Speed is 5 minutes, finishes postheparin salt water sealing (sealing water) pipe (heparin concentration is 1000IU/ml)；
5) proceed the treatment of Blood index, chemotherapeutics residual in blood detected after being finished 1 hour to artery injection,
The air in air bag is set to discharge the blood circulation of recovery parenchymal viscera cardinal vein 10 by check valve 203 after detection is qualified,
Complete seance, three-cavity air bag ductus venosus uses heparin saline tube sealing (heparin concentration is 1000IU/ml)；
6) 60~80IU/kg of LMWHs is injected intravenously after treatment starts, prevents internal blood coagulation.
7) tube drawing by common essence tumour continuously treats two to three times, once a day.
Embodiment 3
Accordingly present invention also offers a kind of application method of parenchymal viscera local chemotherapy system, specifically include following
Step：
1) according to different parts parenchymal viscera tumour, can be through femoral arteriography by the distal end of arterial duct 5 of doser
It is connected to the bifurcated artery 7 that parenchymal viscera supplies tumour.
2) percutaneous puncture of three-cavity air bag ductus venosus body 1 is imported into parenchymal viscera stream cardinal vein or inferior caval vein blood vessel
Interior 10 outlet；
3) three-cavity air bag ductus venosus artery first 201 and vein first 202 are connected using blood filter 4, begins setting up body
The circulation of outer Blood index, after stable circulation by check valve 203 inject air heave air bag 104 to block parenchymal viscera master quiet
Arteries and veins blood flow, extracorporeal blood sorption cycle system is set up and is finished；
4) HDC medicine (using 4 times of systemic chemotherapy dosage) injection is injected by the infusion pump 6 of doser
Speed is 10 minutes, finishes postheparin salt water sealing (sealing water) pipe (heparin concentration is 1000IU/ml)；
5) proceed the treatment of Blood index, chemotherapeutics residual in blood detected after being finished 2 hours to artery injection,
Air in air bag is discharged by recovery parenchymal viscera cardinal vein blood circulation by check valve 203 after detection is qualified, it is complete
Into seance, three-cavity air bag ductus venosus uses heparin saline tube sealing (heparin concentration is 1000IU/ml)；
6) 60~80IU/kg of LMWHs is injected intravenously after treatment starts, prevents extracorporal circulatory system blood coagulation.
7) tube drawing by common essence tumour continuously treats two to three times, once a day.
Embodiment 4
Accordingly present invention also offers a kind of application method of parenchymal viscera local chemotherapy system, specifically include following
Step：
1) according to different parts parenchymal viscera tumour, can be through femoral arteriography by the distal end of arterial duct 5 of doser
It is connected to the bifurcated artery 7 that parenchymal viscera supplies tumour.
2) percutaneous puncture of three-cavity air bag ductus venosus body 1 is imported into parenchymal viscera stream cardinal vein or inferior caval vein blood vessel
Interior 10 outlet；
3) three-cavity air bag ductus venosus artery first 201 and vein first 202 are connected using blood filter 4, begins setting up body
The circulation of outer Blood index, after stable circulation by check valve 203 inject air heave air bag 104 to block parenchymal viscera master quiet
Arteries and veins blood flow, extracorporeal blood sorption cycle system is set up and is finished；
4) HDC medicine (using 4 times of systemic chemotherapy dosage) injection is injected by the infusion pump 6 of doser
Speed is 10 minutes, finishes postheparin salt water sealing (sealing water) pipe (heparin concentration is 1000IU/ml)；
5) proceed the treatment of Blood index, chemotherapeutics residual in blood detected after being finished 3 hours to artery injection,
Air in air bag is discharged by recovery parenchymal viscera cardinal vein blood circulation by check valve 203 after detection is qualified, it is complete
Into seance, three-cavity air bag ductus venosus uses heparin saline tube sealing (heparin concentration is 1000IU/ml)；
6) 60~80IU/kg of LMWHs is injected intravenously after treatment starts, prevents internal blood coagulation.
7) tube drawing by common essence tumour continuously treats two to three times, once a day.
Embodiment 5
Accordingly present invention also offers a kind of application method of parenchymal viscera local chemotherapy system, specifically include following
Step：
1) according to different parts parenchymal viscera tumour, can be through femoral arteriography by the distal end of arterial duct 5 of doser
It is connected to the bifurcated artery 7 that parenchymal viscera supplies tumour.
2) percutaneous puncture of three-cavity air bag ductus venosus body 1 is imported into parenchymal viscera stream cardinal vein or inferior caval vein blood vessel
Interior 10 outlet；
3) three-cavity air bag ductus venosus artery first 201 and vein first 202 are connected using blood filter 4, begins setting up body
The circulation of outer Blood index, after stable circulation by check valve 203 inject air heave air bag 104 to block parenchymal viscera master quiet
Arteries and veins blood flow, extracorporeal blood sorption cycle system is set up and is finished；
4) HDC medicine (using 4 times of systemic chemotherapy dosage) injection is injected by the infusion pump 6 of doser
Speed is 10 minutes, finishes postheparin salt water sealing (sealing water) pipe (heparin concentration is 1000IU/ml)；
5) proceed the treatment of Blood index, chemotherapeutics residual in blood detected after being finished 4 hours to artery injection,
Air in air bag is discharged by recovery parenchymal viscera cardinal vein blood circulation by check valve 203 after detection is qualified, it is complete
Into seance, three-cavity air bag ductus venosus uses heparin saline tube sealing (heparin concentration is 1000IU/ml)；
6) 60~80IU/kg of LMWHs is injected intravenously after treatment starts, prevents extracorporal circulatory system blood coagulation.
7) tube drawing by common essence tumour continuously treats two to three times, once a day.
Embodiment 6
Specifically wrapped present invention also offers a kind of another application method of parenchymal viscera local chemotherapy system accordingly
Include following steps：
1) according to different parts parenchymal viscera tumour, can be through femoral arteriography by the distal end of arterial duct 5 of doser
It is connected to the bifurcated artery 7 that parenchymal viscera supplies tumour.
2) to the patient of inconvenient part Vein Tube, body can be set up by parenchymal viscera stream cardinal vein or inferior caval vein
The outer Blood index circulatory system, parenchymal viscera stream cardinal vein or inferior caval vein are imported by body percutaneous puncture；
3) three-cavity air bag ductus venosus artery first 201 and vein first 202 are connected using blood filter 4, begins setting up body
The circulation of outer Blood index, after stable circulation by check valve 203 inject air heave air bag 104 to block parenchymal viscera master quiet
Arteries and veins blood flow, extracorporeal blood sorption cycle system is set up and is finished；
4) HDC medicine (using 4 times of systemic chemotherapy dosage) injection is injected by the infusion pump 6 of doser
Speed is 10 minutes, finishes postheparin salt water sealing (sealing water) pipe (heparin concentration is 1000IU/ml)；
5) proceed the treatment of Blood index, chemotherapeutics residual in blood detected after being finished 4 hours to artery injection,
Air in air bag is discharged by recovery parenchymal viscera cardinal vein blood circulation by check valve 203 after detection is qualified, it is complete
Into seance, three-cavity air bag ductus venosus uses heparin saline tube sealing (heparin concentration is 1000IU/ml)；
6) 60~80IU/kg of LMWHs is injected intravenously after treatment starts, prevents extracorporal circulatory system blood coagulation.
7) tube drawing by common essence tumour continuously treats two to three times, once a day.
The present invention is obvious to the main arteriovenous such as liver, kidney primarily directed to the system used in parenchymal viscera tumour
Parenchymal viscera curative effect becomes apparent from.
Obviously, described embodiment is a part of embodiment of the invention, rather than whole embodiments.Based on this hair
Embodiment in bright, the every other reality that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example is applied, the scope of protection of the invention is belonged to.
Claims (5)
1. a kind of parenchymal viscera local chemotherapy system, including doser and blood filter device, it is characterized in that, the administration
Device includes arterial duct and infusion pump, and arterial duct distal end connection parenchymal viscera supplies the bifurcated artery of tumour, the other end
Connection infusion pump；The blood filter device includes three-cavity air bag ductus venosus, blood filter and hsempdiakysing systems, described three
Chamber air bag ductus venosus includes the body and base that are connected, and the body connection parenchymal viscera stream cardinal vein or cavity of resorption are quiet
Arteries and veins, the base connects blood filter.
2. parenchymal viscera local chemotherapy system according to claim 1, it is characterized in that, the body include arterial,
Duct of Arantius, air bag and air bag connecting tube；Arterial is identical with duct of Arantius cross section size, and arterial is connected with duct of Arantius distal end
Parenchymal viscera cardinal vein, the other end is connected on base；Air bag is coated on the body；Air bag connecting tube connects with air bag
It is logical, it is located on the inboard wall of tube body of sucquet's canal separation, the other end is connected on base；The base include pipe seat body, artery head,
Vein head and check valve, the first end of artery connect arterial by pipe seat body, and other end connection blood filter, vein is first
End connects duct of Arantius by pipe seat body, and other end connection blood filter, check valve one end connects air bag connecting tube, and the other end can
Connection syringe injection air.
3. a kind of application method of parenchymal viscera local chemotherapy system, it is characterized in that, comprise the following steps：
1) the arterial duct distal end connection parenchymal viscera of doser is supplied the bifurcated artery of tumour through femoral arteriography；
2) percutaneous puncture imports in parenchymal viscera stream cardinal vein or inferior caval vein blood vessel three-cavity air bag ductus venosus, by reality
Matter internal organs stream cardinal vein or inferior caval vein set up extracorporeal blood sorption cycle system；
3) blood filter is attached to hsempdiakysing systems, physiological saline preliminary filling connects the arterial end of three-cavity air bag ductus venosus
And vein end, start hsempdiakysing systems and start blood circulation；The check valve for connecting pipe end by air bag after stable circulation injects
Air makes air bag heave block venous blood stream, and extracorporeal blood sorption cycle system is set up and finished；
4) heavy dose of chemotherapeutics is injected at a predetermined velocity by the arterial duct and infusion pump of doser, finishes rear liver
Plain salt water sealing (sealing water) pipe；
5) proceed the treatment of Blood index, chemotherapeutics residual, inspection in blood are detected after being finished 1-4 hours to artery injection
Survey the qualified rear check valve that pipe end is connected by air bag and the air in air bag is discharged into recovery venous blood circulation, complete
Seance, three-cavity air bag ductus venosus uses heparin saline tube sealing；
6) after treatment starts, 60~80IU/kg of LMWHs is injected intravenously, prevents extracorporal circulatory system blood coagulation；
7) tube drawing by parenchyma continuously treats two to three times, once a day.
4. the application method of parenchymal viscera local chemotherapy system as claimed in claim 3, it is characterized in that, the step 4),
5) heparin concentration of heparin saline is 1000IU/ml.
5. the application method of parenchymal viscera local chemotherapy system as claimed in claim 3, it is characterized in that, the step 4) in
Heavy dose 3-7 times of chemotherapeutics dosage when being systemic chemotherapy, injection rate is 5-30 minutes.
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| CN201030140Y (en) * | 2007-03-29 | 2008-03-05 | 范才 | Oesophagus local hot filling chemotherapy apparatus |
| CN104307064A (en) * | 2014-11-06 | 2015-01-28 | 上海市第六人民医院 | Limb local drug delivery and dialysis device and application thereof |
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| CN201030140Y (en) * | 2007-03-29 | 2008-03-05 | 范才 | Oesophagus local hot filling chemotherapy apparatus |
| CN104307064A (en) * | 2014-11-06 | 2015-01-28 | 上海市第六人民医院 | Limb local drug delivery and dialysis device and application thereof |
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Application publication date: 20170613 |