CN106822894A - A kind of photosensitive agent prescription for optical dynamic therapy periodontitis and its preparation method and application - Google Patents
A kind of photosensitive agent prescription for optical dynamic therapy periodontitis and its preparation method and application Download PDFInfo
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- CN106822894A CN106822894A CN201611267282.7A CN201611267282A CN106822894A CN 106822894 A CN106822894 A CN 106822894A CN 201611267282 A CN201611267282 A CN 201611267282A CN 106822894 A CN106822894 A CN 106822894A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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Abstract
The invention discloses the photosensitive agents formula of optical dynamic therapy periodontitis and application.The aqueogel of this treatment periodontitis, with toluidine blue as photoactive substance, with Carbomer as gel.The formula for optimizing gel preparation includes each component of following mass concentration:Carbomer 0.05%~3%, toluidine blue 0.001%~1%, NaOH 0.01%~0.4% or triethanolamine 0.07%~2%, balance of water.Optical dynamic therapy periodontitis method of the present invention can be with substitute antibiotics therapy, prevent abuse of antibiotics problem, said preparation is used to treat the mouth disease that the infection such as periodontitis causes, the bacteriostasis rate of once irradiating treatment reaches 99.99%, serious patient can be spaced and treat repeatedly, normal organ tissue is had no toxic side effect, with market prospects and application value widely.
Description
Technical field
The invention belongs to pharmaceutical technology field, more particularly to microbiology, specially a kind of optical dynamic therapy periodontitis
Photosensitive gel formulation products and its preparation method and application.
Background technology
Periodontitis is one of big disease in oral cavity three that the World Health Organization (WHO) announces, and be one group is with bacterial plaque microorganism
Initiation factor, being reacted with host causes Periodontal Supporting Tissue (such as gum, parodontium, alveolar bone and cementum) inflammation and breaks
Bad chronic infectious disease.More than 35 years old periodontitis illness rate reaches in China third time Oral epidemiological investigation display crowd
80%-90%, is most pandemic chronic infectious disease in crowd, has a strong impact on oral health, causes bleeding gums, swells
Swollen, absorption of alveolar bone forms the lesions such as oral pocket, while being also be grown up odontoseisis and the main cause for lacking.Additionally, nearly more than ten
Year the experimental results show that periodontal infection is probably one of some important systemic diseases or unusual condition important
Latent dangerous factor, including the birth of angiocardiopathy (atherosclerosis, myocardial infarction and headstroke etc.), premature labor and under-weight
Youngster, diabetes, respiratory tract infection etc..
Periodontitis has high incidence high, it is difficult to effect a radical cure, and the features such as recurrent is strong, current conventional therapy includes mechanotherapy
With application antibiotic therapy.Complicated tooth structure limits the effect of mechanical debridement art, such as subgingival debridement and root planing
Art, although the most dental calculus in root face and bacterial plaque can be removed, but can not effectively be removed in pocket epithelium lining and complex pocket
The microorganism at bottom, therefore need to be subject to various basis auxiliary or further operative treatment, such as whole body or topical antibiotics, Er Qieji
Tool debridement is complex, it is not easy to which by basic hospital, doctor grasps.Using NaOCl, CHG etc. as punching
Although the chemical sterilization dental pulp debridement of lotion has very strong bactericidal effect, but the residence time is too short in dental pulp due to medicine,
Or can not fully erased whole bacterium.And various problems are there is also using antibiotic therapy at present, if heavy dose of,
Prolonged systemic administration can cause flora imbalance；During local application, because washing away for saliva is that medicine is difficult to suffering from for a long time
Place stops, and makes its therapeutic effect undesirable.On the other hand, there are potential drug resistance problems in antibiotic, in recent years antibiotic
Abuse result in being widely current for drug-fast bacteria, and occur in that some multi-drug resistant bacterias are i.e. so-called " superbacteria ".Superbacteria
Prevalence causes the fear of countries in the world, and use of the medical science to antibiotic is more and more careful, therefore the new side of research treatment periodontitis
Method is extremely urgent.Therefore prior art band exploitation can overcome the new treatment of disadvantage mentioned above.
PDT is using the optical characteristics of material, by the generation activity for combining sensitising agent and certain wavelength light wave
Oxygen (ROS), so as to kill the treatment method of the nothing of bacterium/minimally invasive.The method is widely used in the complex treatment of kinds cancer, skin
The multiple fields such as disease treatment, the control of mouth disease and treatment, the method has instant effect, nothing all effective to a large amount of bacteriums
Immune response, have no side effect, reusable advantage.Toluidine blue gel is sensitising agent gel, with following several big advantages：
Gel preparation has certain viscosity and tack, and drag residence can be made to improve therapeutic effect in disease sites.On the other hand
Toluidine blue is a kind of acidophilia dyestuff of nucleic acid tendency, in resting on the more tissue of nuclear fraction.Have in the tissue
Preferable penetration depth, can effectively be distributed in the target tissue of infection, but can not penetrate normal structure, this avoid normal group
Knit it is killed by light power, so toluidine blue has preferably selectivity to lesion region, bacterium.Most important one
Point is that toluidine blue sensitising agent which reduces the harm to human health system without obvious toxic and side effect, is conducive to light to move
The popularization of power therapy and application.The correlative study of the optical dynamic therapy of sensitising agent may be referred to following article：[José A.-Delgado,Pedro M.Castro,Alexandra Machado,et al.Hydrogels containing
porphyrin-loaded nanoparticles for topical photodynamic
applications.International Journal of Pharmaceutics 2016；510:221-231],
[Juliana P.M.L.Rolim,Mary A.S.de-Melo,et al.The antimicrobial activity of
photodynamic therapy against Streptococcus mutans using different
photosensitizers.Journal of Photochemistry and Photobiology B:Biology 2012；
106:40-46]。
The content of the invention
It is an object of the invention to provide the photosensitive gel formulation products and its system of a kind of cooperation optical dynamic therapy periodontitis
Preparation Method, this gel products are main photoactive substance with toluidine blue.
The technical solution adopted by the present invention is as follows：
A kind of photosensitive gel preparation, is mainly formulated by weight percentage by following components：0.001%~1% first
Aniline blue, 0.05%~3% hydrophilic gel, 0.01%~0.4% NaOH or 0.07%~2% 3 ethanol
Amine, balance of water.
Further, hydrophilic gel of the present invention is Carbomer.
Further, water of the present invention is purified water.
Photosensitive gel preparation of the present invention is preferably and is formulated by weight by following components：0.01%~
0.5% toluidine blue, 0.1%~2% hydrophilic gel, 0.04%~0.4% NaOH or 0.1%~1%
Triethanolamine, balance of water.
The preparation of the present invention is mainly formulated by weight percentage by following components：0.001%~1% first
Aniline blue, 0.05%~3% hydrophilic gel, 0.01%~0.4% NaOH or 0.07%~2% 3 ethanol
Amine, balance of water,
(1) it is 0.05%~3% hydrophilic gel is soluble in water, stir evenly, it is allowed to fully swelling；
(2) 0.001%~1% toluidine blue is added in swelling hydrophilic gel and is collected；
(3) 0.01%~0.4% NaOH or 0.07%~2% triethanolamine are added, water is supplied extremely
100%, be sufficiently stirred for fully it is swelling after obtain the photosensitive gel preparation.
Further, hydrophilic gel of the present invention is Carbomer, and preparation method is preferably carried out according to the following steps：
(1) it is 0.1%~2% Carbomer is soluble in water, stir evenly, it is allowed to fully swelling；
(2) 0.01%~0.5% toluidine blue is added in swelling Carbomer and is collected；
(3) 0.04%~0.4% NaOH or 0.1%~1% triethanolamine are added, water is supplied extremely
100%, be sufficiently stirred for fully it is swelling after obtain the photosensitive gel preparation.
Further, treatment of the photosensitive gel formulation application of the present invention in periodontitis.
Beneficial effects of the present invention are：The gel preparation have have no toxic side effect, without immune response, have no side effect, to big
Amount bacterium is all effective, it is reusable the advantages of, the bacteriostasis rate of once irradiating treatment reaches 99.99%, and in the absence of antibiosis
Element produces the problem of drug resistance, it is possible to resolve conventional art cannot effect a radical cure the problem of periodontitis.
Brief description of the drawings
Fig. 1 is positioned over the appearance character figure in centrifuge tube after centrifugation for 1 gram of gel preparation of embodiment 1.
Specific embodiment
With reference to specific embodiment, the present invention is described further, but protection scope of the present invention is not limited in
This.
Embodiment 1
A kind of toluidine blue gel preparation formula for optical dynamic therapy periodontitis, composition is distinguished including percentage by weight
It is 0.5% Carbomer, 0.01% toluidine blue, 0.04% NaOH, water surplus.As a example by preparing one kilogram of gel, by 5 grams
Carbomer is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling, is taken 0.1 gram of toluidine blue and is added in carbomer solution, is stirred
Mix to form gel.Take during 0.4 gram of NaOH adds foregoing gel, be sufficiently stirred for fully swelling, that is, obtain the present invention
Toluidine blue gel preparation.
Embodiment 2
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
3% Carbomer, 0.1% toluidine blue, 0.07% triethanolamine, water surplus.As a example by preparing one kilogram of gel, by 30 gram calorie ripples
Nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.Take 1 gram of toluidine blue to be added in stand-by carbomer solution, stir
Mix to form gel.Take during 0.7 gram of triethanolamine adds foregoing gel, make its total amount be in supplement purified water to gel
1000 grams.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 3
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
0.8% Carbomer, 0.001% toluidine blue, 0.4% NaOH, water surplus.As a example by preparing one kilogram of gel, by 8 gram calories
Ripple nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.Take 0.01 gram of toluidine blue and be added on stand-by carbomer solution
In, stirring forms gel.Take in 4 grams of NaOH foregoing gels of addition, its total amount is made in supplement purified water to gel
It is 1000 grams.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 4
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
2% Carbomer, 0.1% toluidine blue, 0.4% NaOH, water surplus.As a example by preparing one kilogram of gel, by 20 gram calorie ripples
Nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.Take 1 gram of toluidine blue to be added in stand-by carbomer solution, stir
Mix to form gel.Take in 4 grams of NaOH foregoing gels of addition, make its total amount be 1000 in supplement purified water to gel
Gram.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 5
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
0.5% Carbomer, 0.5% toluidine blue, 1% triethanolamine, water surplus.As a example by preparing one kilogram of gel, by 5 grams of Carbomers
It is added in 700mL purified waters, stirs evenly, is allowed to fully swelling.Take 5 grams of toluidine blues to be added in stand-by carbomer solution, stir
Form gel.Take in 10 grams of triethanolamines foregoing gels of addition, make its total amount be 1000 in supplement purified water to gel
Gram.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 6
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
0.05% Carbomer, 0.1% toluidine blue, 2% triethanolamine, water surplus.As a example by preparing one kilogram of gel, by 0.5 gram calorie
Ripple nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.1 gram of toluidine blue is taken to be added in stand-by carbomer solution,
Stirring forms gel.Take during 20 grams of triethanolamines add foregoing gels, make its total amount be in supplement purified water to gel
1000 grams.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 7
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
1.5% Carbomer, 1% toluidine blue, 0.01% NaOH, water surplus.As a example by preparing one kilogram of gel, by 15 gram calorie ripples
Nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.Take 10 grams of toluidine blues to be added in stand-by carbomer solution, stir
Mix to form gel.Take during 0.1 gram of NaOH adds foregoing gel, make its total amount be in supplement purified water to gel
1000 grams.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 8
A kind of toluidine blue gel preparation formula of optical dynamic therapy periodontitis, composition is respectively including percentage by weight
0.1% Carbomer, 0.6% toluidine blue, 0.1% triethanolamine, water surplus.As a example by preparing one kilogram of gel, by 1 gram calorie ripple
Nurse is added in 700mL purified waters, is stirred evenly, and is allowed to fully swelling.Take 6 grams of toluidine blues to be added in stand-by carbomer solution, stir
Mix to form gel.Take in 1 gram of triethanolamine foregoing gel of addition, make its total amount be 1000 in supplement purified water to gel
Gram.It is sufficiently stirred for swelling, that is, obtains toluidine blue gel preparation of the invention.
Embodiment 9
Periodontitis Bacteria Culture is directly taken from patients with periodontitis disease sites overnight, it is 0.31 that bacterium solution is diluted to OD values, is taken
The orifice plate of 100 μ l dilution bacterium solutions value 96, blank group adds the physiological saline of 100 μ l, and experimental group adds side described in 100 μ l embodiments 3
Toluidine blue gel preparation prepared by method.The bacterium solution that blank group and experimental group are reacted is carried out into serial dilution, 100 μ l is taken corresponding
Dilution is coated on LB flat boards, 37 DEG C of culture 18h, and its bacteriostasis rate is calculated by CFU values, and its bacteriostasis rate is 0, illustrates embodiment
It is no bacteriostasis efficacy that toluidine blue gel preparation prepared by tripartite's method does not have LED illumination to coordinate as blank assay.
Embodiment 10
Periodontitis Bacteria Culture is directly taken from patients with periodontitis disease sites overnight, it is 0.31 that bacterium solution is diluted to OD values,
The orifice plate of 100 μ l dilution bacterium solutions value 96 is taken, blank group adds the physiological saline of 100 μ l, and experimental group equally adds the physiology salt of 100 μ l
The LED illumination 30s of water combination 630nm.The bacterium solution that blank group and experimental group are reacted is carried out into serial dilution, 100 μ l is taken corresponding
Dilution is coated on LB flat boards, 37 DEG C of culture 18h, and its bacteriostasis rate is calculated by CFU values, and its bacteriostasis rate is 0, is illustrated to bacterium
Simple light is carried out according to being no bacteriostasis efficacy as blank assay.
Embodiment 11
Periodontitis Bacteria Culture is directly taken from patients with periodontitis disease sites overnight, it is 0.31 that bacterium solution is diluted to OD values, is taken
The orifice plate of 100 μ l dilution bacterium solutions value 96, blank group adds the physiological saline of 100 μ l, and experimental group is added described in 100 μ l embodiments 3
Toluidine blue gel preparation, experimental group uses the LED illumination 30s of 630nm, and blank group is left intact.By blank group and reality
Testing a group bacterium solution for reaction carries out serial dilution, takes the 100 corresponding dilutions of μ l and is coated on LB flat boards, 37 DEG C of culture 18h, passes through
CFU values calculate its bacteriostasis rate, and its bacteriostasis rate is 97.4%.
Embodiment 12
Periodontitis Bacteria Culture is directly taken from patients with periodontitis disease sites overnight, periodontitis Mixed Microbes bacterium solution is diluted to OD
It is 0.31 to be worth, and takes the orifice plate of 100 μ l dilution bacterium solutions value 96, and blank group adds the physiological saline of 100 μ l, and experimental group adds 100 μ l realities
The toluidine blue gel preparation described in example 6 is applied, experimental group uses the LED illumination 30s of 630nm, and blank group is left intact.Will
Blank group and the bacterium solution of experimental group reaction carry out serial dilution, take the 100 corresponding dilutions of μ l and are coated on LB flat boards, 37 DEG C of trainings
18h is supported, its bacteriostasis rate is calculated by CFU values, its bacteriostasis rate is 90.9%.
Preparation performance synthesis is evaluated
1) proterties of gel preparation of the invention：Uniform and smooth, denseness are appropriate.
2) pH value：1 gram of the gel preparation is taken, pH value is determined according to the method that Chinese Pharmacopoeia four general rules of version in 2015 specify
It is 6-8.
3) stability：By gained gel preparation, 1 gram is positioned in centrifuge tube, is allowed to rotate 10 with 4000 revs/min of rotating speed
Minute, gel preparation is layering, not muddy.
4) exclusive use gel preparation of the invention does not have toxicity to bacterium, does not have antibacterial efficiency, and the present invention is used alone
LED illumination, without toxicity, does not have antibacterial efficiency to bacterium yet.
5) bacteriostatic activity：Using the method for plate culture count, by the optical dynamic therapy of toluidine blue gel, tell that technique is joined
Prepared gel preparation combination LED illumination means, 90.998%- is reached to periodontitis pathogenic bacteria bacteriostasis rate in number scope
99.999%.
Claims (7)
1. a kind of photosensitive gel preparation, it is characterised in that the preparation is mainly formulated by weight percentage by following components：
0.001%~1% toluidine blue, 0.05%~3% hydrophilic gel, 0.01%~0.4% NaOH or
0.07%~2% triethanolamine, balance of water.
2. photosensitive gel preparation according to claim 1, it is characterised in that：The hydrophilic gel is Carbomer.
3. photosensitive gel preparation according to claim 1, it is characterised in that：The water is purified water.
4. photosensitive gel preparation according to claim 1, it is characterised in that the preparation is matched somebody with somebody by weight by following components
System is formed：0.01%~0.5% toluidine blue, 0.1%~2% hydrophilic gel, 0.04%~0.4% hydroxide
Sodium or 0.1%~1% triethanolamine, balance of water.
5. the preparation method of a kind of photosensitive gel preparation according to claim 1, it is characterised in that the preparation method is pressed
Following steps are carried out：The preparation is mainly formulated by weight percentage by following components：0.001%~1% toluidines
Indigo plant, 0.05%~3% hydrophilic gel, 0.01%~0.4% NaOH or 0.07%~2% triethanolamine, it is remaining
It is water to measure,
(1) it is 0.05%~3% hydrophilic gel is soluble in water, stir evenly, it is allowed to fully swelling；
(2) 0.001%~1% toluidine blue is added in swelling hydrophilic gel and is collected；
(3) 0.01%~0.4% NaOH or 0.07%~2% triethanolamine are added, water to 100% is supplied,
Be sufficiently stirred for fully it is swelling after obtain the photosensitive gel preparation.
6. a kind of preparation method of photosensitive gel preparation according to claim 5, it is characterised in that the hydrophilic gel
Agent is Carbomer, and preparation method is carried out according to the following steps：
(1) it is 0.1%~2% Carbomer is soluble in water, stir evenly, it is allowed to fully swelling；
(2) 0.01%~0.5% toluidine blue is added in swelling Carbomer and is collected；
(3) 0.04%~0.4% NaOH or 0.1%~1% triethanolamine are added, water to 100% is supplied, is filled
Point stirring fully it is swelling after obtain the photosensitive gel preparation.
7. application of the photosensitive gel preparation as claimed in claim 1 in treatment periodontitis.
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| CN201611267282.7A CN106822894A (en) | 2016-12-31 | 2016-12-31 | A kind of photosensitive agent prescription for optical dynamic therapy periodontitis and its preparation method and application |
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| CN201611267282.7A CN106822894A (en) | 2016-12-31 | 2016-12-31 | A kind of photosensitive agent prescription for optical dynamic therapy periodontitis and its preparation method and application |
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| CN108042801A (en) * | 2017-11-21 | 2018-05-18 | 北京德得创业科技有限公司 | A kind of toluidine blue efficiency light dynamic pasteurization composition and its application |
| CN109821016A (en) * | 2019-02-01 | 2019-05-31 | 浙江工业大学 | Photosensitive gel preparation and preparation method and application thereof |
| CN116173205A (en) * | 2023-01-05 | 2023-05-30 | 吉林大学 | Composite nano material for antibacterial photodynamic therapy of periodontitis and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108042544A (en) * | 2017-11-21 | 2018-05-18 | 北京德得创业科技有限公司 | A kind of toluidines blue light dynamic pasteurization and promotion healing composition and its application |
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| CN109821016A (en) * | 2019-02-01 | 2019-05-31 | 浙江工业大学 | Photosensitive gel preparation and preparation method and application thereof |
| CN116173205A (en) * | 2023-01-05 | 2023-05-30 | 吉林大学 | Composite nano material for antibacterial photodynamic therapy of periodontitis and preparation method and application thereof |
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