CN106815886A - A kind of biological sample tomography cuts imaging device and its method of work - Google Patents
A kind of biological sample tomography cuts imaging device and its method of work Download PDFInfo
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- CN106815886A CN106815886A CN201611253102.XA CN201611253102A CN106815886A CN 106815886 A CN106815886 A CN 106815886A CN 201611253102 A CN201611253102 A CN 201611253102A CN 106815886 A CN106815886 A CN 106815886A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T11/00—2D [Two Dimensional] image generation
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2200/00—Indexing scheme for image data processing or generation, in general
- G06T2200/08—Indexing scheme for image data processing or generation, in general involving all processing steps from image acquisition to 3D model generation
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Abstract
The present invention relates to a kind of biological sample tomography cutting imaging device and its method of work, including feeding module, cutting module, photographing module, controller and computer, cutting module, photographing module are all connected with the controller, feeding module connection cutting module, control module connection computer；Feeding module is used to transport biological sample to be cut, controls travelling speed；Cutting module is used to cut biological sample, and is subject to infrared wire cutting auxiliary；Photographing module is used to shoot the section of the biological sample after cutting；Controller is used for the size of the biological sample for controlling cutting module to cut, and controls photographing module to shoot cutting sample, and the picture of shooting is preserved to storage device；Picture of the computer according to obtained by shooting, the biological sample to cutting carries out three-dimensional reconstruction.The present invention carries out computerized three-dimensional reconstruction using chip technology opposite thing sample as thinly-sliced as possible, can obtain three bit models of accurate biological sample.
Description
Technical field
The present invention relates to a kind of biological sample tomography cutting imaging device and its method of work, belong to biomedical technology neck
Domain.
Background technology
In fields such as biomedicines, it is often required to use the threedimensional model of small-sized biological body, in order to be accurately obtained three bit models,
Cross-section section photo can recover the more accurate threedimensional model of bioagent using three bit recovery technologies, for scientific research or religion
Use.
Tomography is cut into as being used early in most of research for being applied to human body solution plane 16th century as a kind of research method
Be frost cutting method.With the development of science and technology, occurring in that ultrasonic imaging, x-ray computer tomography, magnetic resonance 20th century
The methods such as imaging have further development to human body fault imaging.These research methods be all mostly to the tomography of human body into
Picture, but fault imaging not what effective ways are carried out to other biological, it is impossible to obtain accurate threedimensional model, it has not been convenient to
Scientific research or teaching again is used.
The content of the invention
In view of the shortcomings of the prior art, the invention provides a kind of biological sample tomography cutting imaging device；
Present invention also offers the method for work that above-mentioned biological sample tomography cuts imaging device；
The present invention has invented the imaging device that the biological tomography cuts into picture according to the principle of computer reconstruction 3-D view.
Purpose is, by microsection manufacture technology as thin as possible, to make sectional specimen, gathers two-dimensional image information, then by the information of calculating
It is three-dimensional image that treatment technology rebuilds two-dimensional image information data.By 3 D Printer to required
Model organisms are printed.Accurate threedimensional model is obtained, to be used in scientific research again or teaching.
The technical scheme is that：
A kind of biological sample tomography cuts imaging device, including feeding module, cutting module, photographing module, controller and
Computer, the cutting module, the photographing module are all connected with the controller, and the feeding module connects the blanking punch
Block, the control module connects the computer；
The feeding module is used to transport biological sample to be cut, controls travelling speed；To control to cut sample
Size；The cutting module is used to cut biological sample, and is subject to infrared wire cutting auxiliary；Purpose obtains as thin as possible disconnected
Layer sample.The photographing module is used to shoot the section of the biological sample after cutting；Described controller is used to control
The size of the biological sample of the cutting module cutting, and control the photographing module to shoot cutting sample, will shoot
Picture preserve to storage device；Such as RAM card；Picture of the computer according to obtained by shooting, to the biological sample for cutting
Carry out three-dimensional reconstruction.
According to currently preferred, the cutting module includes infrared module and electronic blade.
According to currently preferred, the feeding module be can rate controlling conveyer belt；The model of the infrared module
TL1838 or VS1838B；The photographing module is the high-definition camera of model QV2640；The controller is STM chips.
Above-mentioned biological sample tomography cuts the method for work of imaging device, and specific steps include：
(1) sample disposal；
(2) controller determines biological sample Cutting Length by infrared module, calculates clipping time, including step
It is rapid as follows：
A, by way of infrared distance measurement, according to launch time and the difference for receiving the time, biological sample is asked for by formula (I)
Cutting Length s, formula (I) is as follows：
In formula (I), c refers to the ultrared light velocity that infrared module sends；T refers to infrared emitting time and when receiving
Between difference；
B, clipping time t1 is asked for, as shown in formula (II)：
In formula (II), h refers to the thickness of biological sample, can artificially measure or measure acquisition by infrared module；V is
Refer to the cutting speed v of electronic blade；The cutting speed can be manually set；
(3) controller determines the speed v1 of feeding module, and biology is marked according to this speed according to clipping time
Originally uniformly cut, the section after being cut is obtained, as shown in formula (III)：
In formula (III), l is the length of section；
(4) controller is carried out in real time by the control to photographing module to the biological sample that step (3) is uniformly cut
Tomography, and the picture of shooting is stored；
(5) picture that step (4) shoots is sent to the computer, three-dimensional reconstruction is carried out by computer.
By using Simpleware softwares, (Simpleware is world-leading 3D rendering digital modeling and finite element fraction
Analysis software.It is the system in how industrial, the multidisciplinary field such as Integrated Reverse-Engineering, material engineering, biomethanics engineering, finite element analysis
The professional software of one solution, including ScanIP, ScanFE, ScanCAD three parts), by continuous tangent plane tomography, both may be used
To re-establish the threedimensional model of biological sample.
According to currently preferred, in the step (1), the sample disposal is specifically included：Sample is filled out with gypsum
Fill, wrap up, make cuboid.
The advantage for designing herein is to be easy to follow-up uniform cutting, shooting and computer digital animation to tangent plane.If
The sample for counting into cuboid is easy to clamp and is cut, and camera imaging is typically rectangle diagram piece, and it is length to be designed to cross section
Square solid is easy to imaging.
Beneficial effects of the present invention are：
1st, the present invention carries out computerized three-dimensional reconstruction using chip technology opposite thing sample as thinly-sliced as possible, can obtain accurately
Three bit models of biological sample.
2nd, picture is cut by the tomography to biological sample, can effectively studies some biological features；
3rd, by the accurate three dimensional biological sample model rebuild, the experimental simulation of correlation can be carried out.
Brief description of the drawings
Fig. 1 is the structured flowchart that biological sample tomography of the present invention cuts imaging device；
Fig. 2 is the application drawing in kind that biological sample tomography of the present invention cuts imaging device；
Fig. 3 is the application drawing in kind two that biological sample tomography of the present invention cuts imaging device；
Fig. 4 is the FB(flow block) of the method for work of biological sample tomography cutting imaging device of the present invention.
Specific embodiment
The present invention is further qualified with reference to Figure of description and embodiment, but not limited to this.
Embodiment 1
A kind of biological sample tomography cuts imaging device, as shown in figure 1, including feeding module, cutting module, shooting mould
Block, controller and computer, cutting module, photographing module are all connected with controller, feeding module connection cutting module, control module
Connection computer；
Feeding module is used to transport biological sample to be cut, controls travelling speed；To control to cut the big of sample
It is small；Cutting module is used to cut biological sample, and is subject to infrared wire cutting auxiliary；Purpose obtains sectional specimen as thin as possible.
Photographing module is used to shoot the section of the biological sample after cutting；Controller is used to control the cutting module cutting
The size of biological sample, and control photographing module to shoot cutting sample, the picture of shooting is preserved to storage device；Example
Such as RAM card；Picture of the computer according to obtained by shooting, the biological sample to cutting carries out three-dimensional reconstruction.
Cutting module includes infrared module and electronic blade.
Feeding module be can rate controlling conveyer belt；The model TL1838 or VS1838B of the infrared module；It is described to take the photograph
As module is the high-definition camera of model QV2640；The controller is STM chips.
The application drawing in kind of biological sample tomography cutting imaging device is as shown in Figure 2 and Figure 3.
Embodiment 2
Biological sample tomography described in embodiment 1 cuts the method for work of imaging device, as shown in figure 4, specific steps bag
Include：
(1) sample disposal；Sample is filled with gypsum, is wrapped up, make cuboid.It is easy to follow-up uniform cutting, to cutting
The shooting in face and computer digital animation.The sample for being designed to cuboid is easy to clamp and is cut, and camera imaging is typically
Rectangle picture, is designed to cross section for rectangular solid is easy to imaging.
(2) controller determines biological sample Cutting Length by infrared module, calculates clipping time, including step
It is rapid as follows：
A, by way of infrared distance measurement, according to launch time and the difference for receiving the time, biological sample is asked for by formula (I)
Cutting Length s, formula (I) is as follows：
In formula (I), c refers to the ultrared light velocity that infrared module sends；T refers to infrared emitting time and when receiving
Between difference；
B, clipping time t1 is asked for, as shown in formula (II)：
In formula (II), h refers to the thickness of biological sample, can artificially measure or measure acquisition by infrared module；V is
Refer to the cutting speed v of electronic blade；The cutting speed can be manually set；
(3) controller determines the speed v1 of feeding module, and biology is marked according to this speed according to clipping time
Originally uniformly cut, the section after being cut is obtained, as shown in formula (III)：
In formula (III), l is the length of section；
(4) controller is carried out in real time by the control to photographing module to the biological sample that step (3) is uniformly cut
Tomography, and the picture of shooting is stored；
(5) picture that step (4) shoots is sent to the computer, three-dimensional reconstruction is carried out by computer.
By using Simpleware softwares, (Simpleware is world-leading 3D rendering digital modeling and finite element fraction
Analysis software.It is the system in how industrial, the multidisciplinary field such as Integrated Reverse-Engineering, material engineering, biomethanics engineering, finite element analysis
The professional software of one solution, including ScanIP, ScanFE, ScanCAD three parts), by continuous tangent plane tomography, both may be used
To re-establish the threedimensional model of biological sample.
Claims (5)
1. a kind of biological sample tomography cutting imaging device, it is characterised in that including feeding module, cutting module, photographing module,
Controller and computer, the cutting module, the photographing module are all connected with the controller, and the feeding module connection is described
Cutting module, the control module connects the computer；
The feeding module is used to transport biological sample to be cut, controls travelling speed；The cutting module is used to cut
Biological sample, and it is subject to infrared wire cutting auxiliary；The photographing module is used to clap the section of the biological sample after cutting
Take the photograph；Described controller is used for the size of the biological sample for controlling the cutting module cutting, and controls the photographing module pair
Cutting sample is shot, and the picture of shooting is preserved to storage device；Picture of the computer according to obtained by shooting, to cutting
The biological sample for cutting carries out three-dimensional reconstruction.
2. a kind of biological sample tomography according to claim 1 cuts imaging device, it is characterised in that the cutting module
Including infrared module and electronic blade.
3. a kind of biological sample tomography according to claim 2 cuts imaging device, it is characterised in that the feeding module
Be can rate controlling conveyer belt；The model TL1838 or VS1838B of the infrared module；The photographing module is model
The high-definition camera of QV2640；The controller is STM chips.
4. a kind of biological sample tomography described in claim 2 cuts the method for work of imaging device, it is characterised in that specific step
Suddenly include：
(1) sample disposal；
(2) controller determines biological sample Cutting Length by infrared module, calculates clipping time, including step is such as
Under：
A, by way of infrared distance measurement, according to launch time and the difference for receiving the time, biological sample is asked for by formula (I) and is cut
Length s, formula (I) is as follows：
In formula (I), c refers to the ultrared light velocity that infrared module sends；T refers to the infrared emitting time and receives the time
Difference；
B, clipping time t1 is asked for, as shown in formula (II)：
In formula (II), h refers to the thickness of biological sample, and v refers to the cutting speed v of electronic blade；
(3) controller determines the speed v1 of feeding module according to clipping time, and biological sample is entered according to this speed
The uniform cutting of row, obtains the section after being cut, as shown in formula (III)：
In formula (III), l is the length of section；
(4) controller carries out tomography in real time by the control to photographing module to the biological sample that step (3) is uniformly cut
Shoot, and the picture of shooting is stored；
(5) picture that step (4) shoots is sent to the computer, three-dimensional reconstruction is carried out by computer.
5. a kind of biological sample tomography according to claim 4 cuts the method for work of imaging device, it is characterised in that institute
State in step (1), the sample disposal is specifically included：Sample is filled with gypsum, is wrapped up, make cuboid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611253102.XA CN106815886A (en) | 2016-12-30 | 2016-12-30 | A kind of biological sample tomography cuts imaging device and its method of work |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611253102.XA CN106815886A (en) | 2016-12-30 | 2016-12-30 | A kind of biological sample tomography cuts imaging device and its method of work |
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| CN106815886A true CN106815886A (en) | 2017-06-09 |
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| CN201611253102.XA Pending CN106815886A (en) | 2016-12-30 | 2016-12-30 | A kind of biological sample tomography cuts imaging device and its method of work |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111417847A (en) * | 2017-11-30 | 2020-07-14 | 徕卡显微系统(上海)有限公司 | Control motor slicing machine |
| CN111726587A (en) * | 2020-06-29 | 2020-09-29 | 康湃医疗科技(苏州)有限公司 | Specimen shooting system and shooting method thereof |
| CN113729060A (en) * | 2021-09-10 | 2021-12-03 | 武汉轻工大学 | Automatic milling and slicing system for frozen poultry based on machine vision |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1249209A1 (en) * | 2001-04-09 | 2002-10-16 | Ethicon Endo-Surgery, Inc. | Biopsy instrument with tissue marking element |
| CN102175175A (en) * | 2011-01-26 | 2011-09-07 | 中国地震局地质研究所 | Small slice type three-dimensional structure reconstruction system |
| CN103829924A (en) * | 2012-11-26 | 2014-06-04 | 三星电子株式会社 | Apparatus and method for generating tomography images |
| CN105023295A (en) * | 2015-08-05 | 2015-11-04 | 成都嘉逸科技有限公司 | Human anatomy unit 3D model establishment method and teaching system |
-
2016
- 2016-12-30 CN CN201611253102.XA patent/CN106815886A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1249209A1 (en) * | 2001-04-09 | 2002-10-16 | Ethicon Endo-Surgery, Inc. | Biopsy instrument with tissue marking element |
| CN102175175A (en) * | 2011-01-26 | 2011-09-07 | 中国地震局地质研究所 | Small slice type three-dimensional structure reconstruction system |
| CN103829924A (en) * | 2012-11-26 | 2014-06-04 | 三星电子株式会社 | Apparatus and method for generating tomography images |
| CN105023295A (en) * | 2015-08-05 | 2015-11-04 | 成都嘉逸科技有限公司 | Human anatomy unit 3D model establishment method and teaching system |
Non-Patent Citations (1)
| Title |
|---|
| 姚如永等: "《中西医结合实验技术》", 30 September 2013 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111417847A (en) * | 2017-11-30 | 2020-07-14 | 徕卡显微系统(上海)有限公司 | Control motor slicing machine |
| CN111726587A (en) * | 2020-06-29 | 2020-09-29 | 康湃医疗科技(苏州)有限公司 | Specimen shooting system and shooting method thereof |
| CN113729060A (en) * | 2021-09-10 | 2021-12-03 | 武汉轻工大学 | Automatic milling and slicing system for frozen poultry based on machine vision |
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Application publication date: 20170609 |