CN106796431A - System, method, computer program product and user interface for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process - Google Patents
System, method, computer program product and user interface for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process Download PDFInfo
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- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B23/00—Testing or monitoring of control systems or parts thereof
- G05B23/02—Electric testing or monitoring
- G05B23/0205—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults
- G05B23/0218—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults characterised by the fault detection method dealing with either existing or incipient faults
- G05B23/0224—Process history based detection method, e.g. whereby history implies the availability of large amounts of data
- G05B23/0227—Qualitative history assessment, whereby the type of data acted upon, e.g. waveforms, images or patterns, is not relevant, e.g. rule based assessment; if-then decisions
- G05B23/0237—Qualitative history assessment, whereby the type of data acted upon, e.g. waveforms, images or patterns, is not relevant, e.g. rule based assessment; if-then decisions based on parallel systems, e.g. comparing signals produced at the same time by same type systems and detect faulty ones by noticing differences among their responses
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- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
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- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
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Abstract
The present invention relates to a kind of computer system for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process, computer implemented method, computer program product and user interface, it includes Unit at least two, the unit is designed to receive material or material, to carry out at least one biology, biochemistry, chemistry and/or physical process on the material.Each unit has at least one sensor, and the sensor is designed to the detection measurement data related to the process.In addition, computer system includes at least one display unit, by the display unit, two measurement data of unit are shown with corresponding temporal correlation, and the temporal correlation allows to obtain information based on the intrinsic relation in shown measurement data.
Description
Technical field
The present invention relates to one kind for controlling, detecting, adjusting and/or analyzing biology, biochemistry, chemistry and/or physics
The computer system of process, computer implemented method, computer program product and user interface.
Background technology
Known system realizes the display of measurement data in real time, and the data can be captured by the sensor of unit, i.e. institute
The measurement data of display is coupled with current process time.Measurement can not possibly be shown independently of the absolute time of capture measurement data
Data.The display is carried out by display unit, and the display unit is with bioreactor or filter or freezing and except defrosting system
Connection.In addition, it is important that can generally be set to carrying out biology, biochemistry, chemistry and/or physical process by display unit
Parameter.Parameter may, for example, be pH value, oxygen supply etc..Therefore, the visualization of the detailed process of measurement data and process
The control of parameter is possible.
However, when biology, biochemistry, chemistry and/or physical process are carried out in the unit comprising reactor, obtaining
It is very heavy to influence the accurate general introduction of the key factor of the process and the change of these factors influential on the success of process
Want.For this reason, it is necessary to be compared to each other the different process configurations and/or identical process started in different absolute times and/
Or different configurations for example in one or more batch data stages (batch phase) of various process or batch data
Measurement data stream.Traditional system can not be presented with temporal correlation (temporal correlation) in this way
Such measurement data stream, the intrinsic relation so as to be based in detected measurement data obtains information.
The content of the invention
It is therefore an object of the present invention to can in an improved way record and further process biology, biochemistry, chemistry
And/or the measurement data of physical process.
The purpose of the present invention is realized by the feature of independent claims.Embodiment preferably is the master of dependent claims
Topic.According to the present invention, the purpose is realized by the feature of independent claims.Preferred embodiment is the master of dependent claims
Topic.
The first aspect of the present invention provides a kind of for controlling, detecting, adjusting and/or analyzing biology, biochemistry, change
And/or the computer system of physical process, including：
At least two entities or unit, it is designed to receive material or material, and at least one is carried out with to the material
Biology, biochemistry, chemistry and/or physical process；
Wherein, each unit has at least one sensor, and the sensor is configured as the detection survey related to the process
Amount data；With
At least one display unit, two measurement data of unit are by the display unit with respective temporal correlation
(temporal correlation) shows, the temporal correlation allows to be obtained based on the relation between presented measurement data
Information.
Reactor may, for example, be bioreactor and/or chemical reactor, and it is configured as reception can enter thereon
The material or material of at least one biology of row, biochemistry, chemistry and/or physical process.In bioreactor, it is possible to use
The one-time reaction device and the solids container that is made of stainless steel of bag form or (free-standing) device form of supporting oneself.
According to the type of culture, bioreactor is filled with solid material, to set up adherent cell (adherent cells), or quilt
It is configured to stirred reactor.
Or or in addition to reactor, unit especially can be used for the filtering of filter medium including at least one
Device.For example, this can be the filter for cross-flow filtration, its purification that can be for example used for protein or protein component
And/or separate；Can be the filter for carrying out film layer analysis, such as isolating cellular components, nucleic acid, virus, mycoplasma
Or endotoxin；Can be clarifying filter, such as purifying serum solution or plasma solutions；Can be virus filter, example
Such as it is used for isolated viral and/or virus composition；Can be UV-C inactivating systems, such as isolated viral and/or virus composition；
And/or for the tangential flow filter or cross-flow filter of liquid filtering, such as in food and/or pharmaceuticals industry.
Used as reactor or the replacement or supplement of filter, unit can particularly comprise at least one freezing and system of thawing
System, it is configured as repeatably being freezed and defrosting biopharmaceutical liquids for example in production and process development.
Material can be liquid, gas and/or solid.The material can by order to make the method carry out needed at least
A kind of component composition.Thus, for example, culture for microorganism, it is necessary to produce and maintain to ensure organism optimum growh must
Want condition.For example, so important condition can be nutrient medium or nutritive solution, oxygen content, pH value and/or biological respinse
The combination of the temperature in device.The final purpose of culture can be obtained organism or part biological body and/or secretion or do not divide
The metabolite secreted, it can be used as active material in pharmaceuticals industry or be used as basic chemicals in chemical industry.This
Outward, the purpose of culture can be chemical decomposition composition, such as sewage disposal or the fermentation for food.
In this case, each unit can respectively by least one reactor, at least one sensor and can
One or more single control units of selection of land and processing unit are constituted, from terms of logical view, they together constituent apparatus one
Part, one or more procedure activations can be carried out in the apparatus.Each unit is always only produced in the preset time section of process
A raw batch data.Therefore, specific process can be presented by each unit, such that it is able to be detected simultaneously by sensor
All measurement data needed for display process record or process monitoring.
The measurement data of the material occurred during being present in the material in unit and/or carrying out wherein is not by special
Limit and be heavily dependent on it is respective application and its purpose or task, the measurement data by computer system detect,
Display and may be related to the measurement data of other units.Data can for example be related to cell density, cell growth rate, culture
The quantity of base, the generation of the foam of culture medium, the pH value of culture medium, the temperature of culture medium, the oxygen content of culture medium, culture medium
Carbon dioxide content, the turbidity (clouding) of culture medium, the electric capacity of culture medium and/or electrical conductivity, the certain content of culture medium
Metabolite, the concentration of peptide and/or protein, the bioreactor for being produced in concentration, the culture medium of thing or nutrients and being secreted
Specific part in flow velocity or bioreactor operating parameter.For detecting this or other measurement data corresponding biography
Sensor by any specific limitation and is not in the prior art known.Measurement number can be detected in specific time interval
According to.Time interval is preferably between about 500 and about 60,000ms.Preferably can by sensor (poll)
Recover measurement data with from each unit.
In the embodiment of pending fermentation, unit can be by container (such as bioreactor, filter or freezing
With defrosting system), sensor is (such as analyzing O2And/or CO2Gas analyzing apparatus) and another single control unit
(for example, ratio control unit).Each in these parts can be connected by corresponding device with the unit.Each device
Can be communication interface or input/output interface or communication interface.Separation between unit and device can effectively and simply
Realize, and with advantages below：Unit (it is made up of at least one reactor), at least one sensor and most diverse
Single control unit can be connected by device in simple and efficient mode with a unit, such as by network.Additionally,
Communication angle, can clearly be distinguished between technical standpoint and process angle.Therefore, in the aforementioned embodiment, gas point
Analysis apparatus can be connected by USB (USB) and are connected with unit, wherein, sensor device is used as communication interface.Example
Such as, bioreactor can via Ethernet and the elements exchange data, wherein, reactor assembly can serve as communication interface.
Ratio control unit can be coupled to unit by single control unit device.The independent control unit in required inside can
Selection of land is connected with the unit.It is for instance possible to use be circulated calculating instead of the computing module of device, and therefore with device
Similar mode is cyclically supplied to control module using result as value.Sample data management module can be manually entered collection
Sample data, the sample data of the collection only determines from the sample in laboratory.The logical combination of all parts forms a list
Unit, the advantage of the unit can be achieved on the separation of device communication (device) and monitoring, that is, process rank (process
Level) (unit).
Each unit has at least one sensor, the sensor be designed to detection it is related to process it is specific (i.e.
It is predetermined or can be predetermined) measurement data.In this case, for example, sensor can be gas sensor, such as O2Or CO2
Lambda sensor, pH sensors, glucose sensor, lactate sensor and to be designed to detection suitable on pending mistake
Any other sensor of the measurand of journey, or these sensors any combinations.Alternatively, each unit can be in addition
Ground has at least one single control unit.This is equally applicable to filter.Separative element/device sets for modularization
Put, each user can be set by the modularization and configure the technical process of oneself in a standardized manner and manufactured without engineering
(engineering)。
Measurement data can be shown by display unit, such as in the form of experiment curv.As the replacement to this or increasing
Plus, measurement data can be shown in the form of one or more figures, for example pie chart, line chart, bar chart, organization chart, Gantt chart,
Flow chart, cause effect figure, block diagram etc..Measurement data may, for example, be floating number type, integer type, double, character string type
Or Boolean type.
Measurement data can be stored in database, and the database is suitable for the survey will be stored with short time interval at a high speed
Measure data output to corresponding database entry.For example, effective data compression can be realized in database.
For example, measurement data can be made up of following variable：
- MappingShortID → identification control module variable；
- Timestamp → timestamp：When measurement data is received in the cells
The measured value of-Value → measurement data；
- Quality → binary value, such as 0 represents " good ", and 1 represents " bad "；The quality can determine the measurement number
Whether shown by the display unit according to item；
- Checksum → generated by computer system, to prevent data manipulation；This has the peace for increasing computer system
The advantage of full property.
In order to optimize the incubation of cell, it is necessary to obtain the accurate summary of the key factor of the process, on the one hand, example
Such as oxygen content and change the successful influence of these factor pair processes, it is on the other hand, such as new by supplying oxygen or addition
Nutrient medium cell growth influence.This can be realized in an efficient way, such as in two processes in different units
In simultaneously run in the case of, show two measurement data of the sensor of unit, Neng Gou by with each temporal correlation
Obtained in the measurement data of display based on solid related information.
Especially, its this have the advantage that, can with the different significant process of simple and efficient mode real-time detection because
The influence of element changes the influence of one or more such process factors.It is thereby achieved that process workflow (process
Workflows Filled function) or improvement.Especially, due to can be adjusted when process is run in the cells biological, chemistry,
The setting of biochemistry and/or physical process parameter, it is thus achieved that the interaction of improved, continuous user/machine.This
Can occur particular according to the input of user and/or by the automatic identification of the temporal correlation of measurement data.Therefore, make
The coordination or mediation for obtaining the technical operation in unit are possibly realized.
Additionally, the different technologies state of generally existing in unit can be shown by means of display unit.
Especially, if it exceeds or less than (undershot) to each biology, biochemistry, chemistry and/or physical process
Important condition (if the oxygen content of the material in such as reactor is too low or too high), can be shown by display unit and warned
Report.
Further, since can in real time set essential to each process during each process workflow
Parameter, it is thus possible to which technical controlling is carried out to unit.
Another advantage is：By means of temporal correlation, can be by output unit independently of the measurement data for detecting
Absolute time obtains the correlation technique relation of process.Furthermore it is possible in the retention time duration correlation of various process
And the temporal correlation can be shown by display unit.
Therefore, user can more effectively and quickly administrative skill task, the technical assignment is monitoring technology technology ginseng
The various technologies of intrinsic technical relation and monitoring process workflow in number, control technology procedure parameter, detection various processes
The influence of parameter.
In addition, computer system preferably includes detection unit, the detection unit is designed to：
By the measurement data stream of the unit that mutually compares, recognition time correlation；With
The corresponding measurement number of unit can be shown independently of the absolute time of capture measurement data by display unit
According to.
For recognition time correlation, two units can be merged into a group (unit packet) by detection unit first.
In this case, with unit it is same type or unrelated including identical sensor or single control unit.Therefore, it is
System realizes free location packet (grouping), the temporal correlation that detection unit can be grouped with recognition unit.
The temporal correlation of measurement data can be recognized by any way, basically as function and its mesh that each is applied
Or target.For example, the not measurement data of commensurate,
- above or below one or more are specific (i.e. predetermined or can be predetermined) absolute value or threshold value and/or one
Or multiple relative value (such as pH value, CO2Value or O2Value)；
- correspond to the highest or floor level for measuring；
- correspond to specific (i.e. predetermined or can the be predetermined) increase of curve, can for example represent growth rate；
- corresponding to specific (correlation) reduction of curve, can for example represent the death rate；
- to describe univariate data after (inspection of such as distribution, the calculating of distributed constant, graph data
Analysis or correlation analysis), corresponding to the correlation between the individual variable of specific (correlation) measurement data；
- after to principal component analysis (PCA), with specific (i.e. predetermined or can be predetermined) packing density；
- after PLS (PLS) and/or discriminant analysis and/or cluster analysis is carried out, have in data
Specifically (i.e. predetermined or can be predetermined) structure or classification；And/or
- after the method for performing advanced multivariate data analysis (such as multichannel principal component analysis), have in data
There is specific (i.e. predetermined or can be predetermined) structure.
In other words, as measurand, by means of the measurand, the measurement data of two or more units can be with that
This is related (hereinafter referred to as " correlated characteristic ") in time, and over time, feature depends on corresponding application and its work(
Energy or purpose.Such correlated characteristic can be it is following in one or more：Reach, above or below selection limiting value,
The unexpected increase of measurement data or reduce suddenly, the of short duration and temporary transient of measurement data increases or decreases (peak value) or reaches measurement
The predetermined gradient value of data.Example for less than or more than culture medium specified temp or pH value, reach needed for cell density, reach
Required growth rate, produce in culture medium less than or more than the oxygen of culture medium and/or the limiting value of carbon dioxide content or reached
The required concentration of raw metabolite.
The temporal correlation of measurement data has advantages below：The measurement data of unit be particularly it is automatic than than
Specific (i.e. predetermined or can be predetermined) condition is met afterwards, can be by display unit independently of the absolute of the detection of measurement data
Time showing, information is obtained such that it is able to be based on intrinsic relation in the data.
When the time window of specific (i.e. predetermined or can be predetermined) ratio is applied to the measurement data of unit, can
Preferably to show temporal correlation, so that the measurement data in time window is independently of the exhausted of the detection of measurement data
Time is shown with temporal correlation.
Specifically, time window can apply to measurement data, wherein, display unit has scaling bar, on the scaling bar
There is provided zoom control.By means of suitable input unit (such as computer keyboard, computer mouse, touch-screen input etc.),
It is the time window of N that user move zoom control can be based on a collection of measurement data moving ratio by scaling bar.With this side
The time window that formula is used is hereinafter also referred to as browsing (thumb).In addition to scaling bar shows, also in viewing area in detail
Carefully show the time window that ratio is N.Therefore, each measurement data for being zoomed in and out with scaling bar (is become with time window
Gesture) form show.
For example, by least one sensor detect measurement data can be combined as data compilation (compilation) or
Data set collects.For example, the data of each batch can be comprising from fills unit (such as bioreactor or filtering dress
Put) all measurement data, to complete the emptying of the unit, the unit is in specific (i.e. predetermined or can the be predetermined) time period
It is detected afterwards, such as after reaction time, growth time or filter process.The order that data can continuously be collected according to it
With time showing.Exist in the data (off-line data) determined (such as after material centrifugation) after each process is estimated to material
The appropriate time after a while is optionally added in measurement data.Especially, storage in batch data measurement data (under
Text is also referred to as batch data) can be used for the certification of each process, and therefore meet the respective standard of process production.
Due to higher than specific packing density, it is impossible to while all data in combination are shown, by means of department of computer science
System, can be with default settings, according to the default value, and display unit always shows detected and is added to batch data
In last N number of data or data set, wherein N defines the data or data of specific (i.e. predetermined or can be predetermined) quantity
Collection.This can be solved with adjustable time cycle.Therefore, can be independently of institute by storing the MinMax bars of the time cycle
The time period of setting shows all measurement data.
When the time window of specific (such as predetermined or can be predetermined) size is applied to the measurement data of unit,
Temporal correlation can be shown, so, the measurement data in time window can be independently of the exhausted of the detection of measurement data
Time is shown together with temporal correlation.In this case, this temporal correlation or synchronism of measurement data can be with
It is retained in display unit, even if new measurement data is included in batch data (batch).In other words, display unit exists
Can only retain and show the data of the time correlation in time window during two current operations.For example,
During the further operation of process, the absolute time that measurement data can be detected independently of it is via with temporal correlation
Time window show that the measurement data has passed through the sensors detection of two units and in the measurement number by display unit
According to it is automatic relatively after meet specific (for example, default or predeterminable) condition.In this case, examined by sensor
The new data or data set for surveying and being added to corresponding batch data are not shown by display unit.
In another embodiment, due to via the sensor of unit with the measurement data of different time interval measurement
Time correlation each other, thus temporal correlation can be set.Especially, it is suitable for the size of the time window of each batch data
Rewritable (adapt), thus measurement data corresponds to each other in their time interval.
Temporal correlation is preferably set to the function of user input.
For example, the scaling bar by being provided with zoom control, user (can for example count by suitable input unit
Calculate switch disk, computer mouse, touch-screen input etc.) pass through the measurement data that mobile zoom control movement is shown by display unit
Region.
This this have the advantage that, because the control that user can be by the progress with the time by means of display unit is controlled respectively
The display of the measurement data of individual unit and can show the measurement data with temporal correlation.
Additionally, being located at the point scaled on bar for browsing outside by selection and by means of suitable input unit (for example, meter
Calculate switch disk, computer mouse, touch-screen input etc.), user can set the width browsed, thus show many data.Cause
This, the end for browsing (thumb) positioned at the side of institute's reconnaissance extends towards the point.
Especially, by means of suitable input unit, user can increased or decrease the width browsed and in scaling bar
Inside arbitrarily to the right and it is moved to the left and browses.This this have the advantage that, when process is run in the cells, independently of measured value
The absolute time of detection, can control to show the state of the art of unit and the technical relation of correlation.
Two measurement data of unit preferably shows by the display unit in each viewing area, wherein, in setting
Period, in each viewing area, by zoom control, user will in specific (for example, default or predeterminable) time
Each time window is applied to measurement data, the time window of the adjustable measured value to be shown of the zoom control or browses and can
Moved along measurement data with each viewing area.
For example, by means of zoom control, user can manually show measurement data, the measurement data is provided in pure culture
Yeast cells incubation in temperature information, wherein, the process still operation and therefore new measurement data is always stored in
In batch data.If user finds associated temperature value, user can show experiment curv since the associated temperature value, so as to
Monitor other Temperature Distribution forward from correlation time, i.e., independently of the absolute sense time of measured value.
For example, the measurement data of each unit can be combined with special batch data (dedicated batch).Therefore,
The measurement data of each unit may be displayed in (i.e. predetermined or can be predetermined) region of the respective specific of display unit, with
Viewing area is also referred to as down.In this embodiment, each display unit is provided with corresponding scaling bar.
For example, a scaling bar can correspond to each viewing area.Therefore, by the corresponding zoom control of movement, use
Family can select the particular measurement data of display by the corresponding zoom control of movement.
This this have the advantage that, within specific (i.e. predetermined or can the be predetermined) time period, user can individually and
The measurement data of each unit in two units is controlled independently of one another and/or measurement number can be shown by display unit
According to.Another advantage is, by means of temporal correlation, can by output unit independently of the measurement data for detecting absolute time
Between obtain the correlation technique relation of process.Additionally, by means of time window or browse, the temporal correlation of technical relation can be
Kept in the duration of various process.
Computer system preferably also includes control module, and the control module is designed to be combined into Unit at least two
Group.The group can be controlled by control module.Furthermore, it is possible to passing through control module adjusts measurement data.
For example, time window can each other be linked or they are placed or are connected each other with certain proportion by control module
Connect, so, unit is automatically shown independently of the detection absolute time of measurement data by display unit with time phase
The measurement data of pass.Therefore, automatically mobile on the region of each batch data that can meet condition in measurement data scale
Bar.
The measurement data stream of process is hereinafter also referred to as trend.In the synchronizing process of trend, criticized by means of representing
The width for measuring the trend of the first scaling bar of N number of measurement data of data may adapt to by means of representing being more than for batch data
Or the width of the second trend for less than the second of N number of measurement data scaling bar, thus the identical time period is shown in trend.
This this have the advantage that：The simultaneous display of different significant process factors or one or more such processes because
The change of element can real-time control in a simple and effective way.
Additionally, control module is designed to each other link the time window of the time correlation of unit, so, by
In the zoom control of scaling bar, by the window for only moving single disposable (one-time) so that user can be by means of
Single zoom control, the multiple time windows of control.For example, it is automatically generating or by user by first scaling bar (actuator) produce
Each raw action is reflected in the second scaling bar (reactor).In this case, the execution action in reactor can not be complete
Full application, but correspondingly only partially perform in the reactor.In this case, the behavior can not enter in the reactor
OK, the behavior can fall back in the reactor (reverse).
For example, if that browses widened the left side being directed towards in actuator, however, it would be possible on reactor, only could be with
Action is partly performed, although not being the degree for starting.In this case, make to browse the starting operation widened only in reaction
The possible region of device performs (and therefore limiting actuator).If can not possibly widen browsing in the reactor, no
Perform action.
The link of time window has the technological merit improved to the control of each procedure parameter.Additionally, user can be independently of
The absolute sense of corresponding measured value, obtains the correlation technique relation of various process, which achieves the improvement corresponding technology of analysis
The technological merit of procedure parameter.
Additionally, control module is preferably designed to be in same time and starts in unit independently of absolute time
The process carried out on material.
Either this can automatically be carried out with by the time for determining to start, or manually entered by suitable user input
OK.
The material is preferably the composition being made up of fluid liquid and gaseous fluid, such as full of the water-soluble of nutriment
Liquid, is added thereto to microorganism to be cultivated.Additionally, for example in order to cultivate adherent cell, composition includes solid, in the solid
Upper precipitation has cell.However, material can have pure chemistry property and without microorganism.
According to another aspect of the present invention, the purpose of the present invention by for control, detect, adjust and/or analyze biology,
The computer implemented method realization of biochemistry, chemistry and/or physical process, wherein, the method includes following functions：
At least two entities or unit are provided, its be designed to receive material or material, so as to carried out on the material to
Few one kind biology, biochemistry, chemistry and/or physical process, wherein, each unit has at least one sensor；
The measurement data related to each process is detected by sensor；With
Two measurement data of unit are shown with temporal correlation by display unit；
Wherein, temporal correlation allows to obtain information based on the intrinsic relation in shown measurement data.
Therefore, user can more efficiently and quickly management and monitoring technical parameter, control technology procedure parameter, detection be each
The technical assignment of the influence of intrinsic technical relation and the various technical process parameters of monitoring to process workflow during individual.
Additionally, the method preferably includes following functions：
By detection unit by compare unit measurement data operation come recognition time correlation；With
The corresponding measurement data of unit is shown independently of the absolute time of capture measurement data by display unit.
Preferably, when the time window with specific (i.e. predetermined or can be predetermined) size is applied to the survey of unit
During amount data, temporal correlation can be shown so that the measurement data in time window shows with temporal correlation, and independently of survey
Measure the absolute time of the detection of data.
Preferably, temporal correlation is arranged to the function of user input.
Preferably, two measurement data of unit can be shown by the display unit in corresponding viewing area.
Moreover it is preferred that during setting, in each viewing area, by means of zoom control, user it is specific (such as
It is predetermined or can be predetermined) corresponding time window is applied to measurement data by the time, the zoom control can show accordingly
Moved along measurement data in region.
Preferably, the method also includes following functions：
Unit at least two are combined to form group by control module, thus the group can be controlled by control module.In addition, logical
Cross and perform the adjustable measurement data of the control module.
Preferably, the method also includes following functions：
By control module can link time window, these time windows by means of corresponding units measurement data using simultaneously
And be respectively displayed in viewing area so that user can be based on the measurement data of unit by synchronous by zoom control
Ground traveling time window carrys out control time window.
Preferably, the method also includes following functions：
By control module, while and independently of absolute time, starting to be performed on the material of unit carries out the mistake
Journey.
According to another aspect of the present invention, the purpose of the present invention realized by a kind of computer program product, the calculating
Machine program product includes program part, when the program part is loaded on computer, is adapted for carrying out computer implemented side
Method, wherein, the computer implemented method includes following functions：
By detection unit by compare unit measurement data operation come recognition time correlation；With
Independently of the absolute time of the capture of the measurement data, phase is shown in time upper corresponding mode by display unit
The measurement data answered.
Preferably, when the time window with specific (such as predetermined or can be predetermined) size is applied to the survey of corresponding units
During amount data, the temporal correlation can be shown so that the measurement data in time window is independently of measurement test
Absolute time shown with temporal correlation.
Preferably, temporal correlation can manually be set by user.
Preferably, two measurement data of unit can be shown in corresponding viewing area by display unit.
Furthermore it is preferred that during setting manually, in each viewing area, by means of zoom control, user is specific
Corresponding time window is applied to measurement data by (such as predetermined or can be predetermined) time, and the zoom control can show accordingly
Show that region is moved along measurement data.
Preferably, the method also includes following functions：
Unit at least two are combined to form group by control module, thus the group can be controlled by control module.
Preferably, the method also includes following functions：
By control module can link time window, these time windows by means of corresponding units measurement data using simultaneously
And be respectively displayed in viewing area so that user can be based on the measurement data of unit by synchronous by zoom control
Ground traveling time window carrys out control time window.
Preferably, the method also includes following functions：
By control module, starting simultaneously to be performed on the material of unit carries out the process.
According to another aspect of the present invention, the purpose of the present invention by for control, detect, adjust and/or analyze biology,
The graphical user interface (GUI) of biochemistry, chemistry and/or physical process realizes, wherein, GUI includes：
With specific (such as predetermined or can be predetermined) size and specific (such as predetermined or can be predetermined), position be at least
Two viewing areas, wherein, each viewing area is associated with a unit, and the unit is designed to receive material or material,
To carry out at least one biology, biochemistry, chemistry and/or physical process on the material；
Wherein, each unit has at least one sensor, and the sensor is designed to the detection survey related to process
Amount data；And
Wherein, in each viewing area, two measurement data of unit are shown with corresponding temporal correlation, the time
Correlation causes that the relation that can be based between presented measurement data obtains information.
Brief description of the drawings
Preferred embodiment described by reference to the following drawings.Even if it should be noted that individually description is implemented
Example, its each feature can also be combined, to produce further embodiment.In the accompanying drawings：
Fig. 1 is illustrated for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process
The embodiment of computer system.
Fig. 2 illustrates the embodiment of the setting of unit.
Fig. 3 illustrates the structure and the embodiment of relation of the measurement data of the unit for being incorporated to batch data (batch).
Fig. 4 is to be combined into a schematic diagram of the two of group units.
Fig. 5 is illustrated and is shown the embodiment that measurement data is exported by display unit.
Fig. 6 illustrates two embodiments of the arrangement for browsing (thumb).
Fig. 7 illustrates the embodiment for showing measurement data before the synchronization.
Fig. 8 is illustrated after synchronization, the measurement data in display such as Fig. 7.
Fig. 9 is synchronous process flow diagram flow chart.
Figure 10 is to make the visual process flow diagram flow chart of link process of scaling bar (zoombar) as described in Fig. 7 and Fig. 8.
Figure 11 illustrates the embodiment for realizing present system.
Specific embodiment
Fig. 1 is illustrated for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process
Computer system 160.Computer system 160 shown in Fig. 1 includes multiple but at least two unit 135A to 135N (135A-N),
These units are designed to receive material or material, with carry out on the material at least one biology, biochemistry, chemistry and/
Or physical process.Each unit 135A-N has at least one sensor 140A-140N (140A-N), and the sensor is configured as
The detection measurement data relevant with the process.Additionally, computer system 160 includes at least one display unit 100, it is aobvious by this
Show unit 100, the measurement data of unit 135 is shown with respective temporal correlation, the temporal correlation is allowed based on shown
Measurement data in intrinsic relation obtain information.For example, the measurement data of unit 135A-N can be in special viewing area
Shown in domain 105,110.Additionally, by means of corresponding zoom control (zoom control) 125,130, user is single by showing
Time window can be applied to the measurement data of each batch data by corresponding scaling bar 125,130 for unit 100, so that
Measurement data stream from each time window can be exported independently of the absolute time of measurement data by display unit 100.
Especially, based on controlling, detecting, adjust and/or analyze biology, biochemistry, chemistry and/or physical process
Calculation machine system 160 can be designed as DAM control (SCADA) system.Therefore, it can by computer monitoring, control
System and/or regulation technical process (technical process).
In SCADA system, especially, the automation mechanized operation corresponding to open system interconnection (OSI) layer model can be with
Multiple layers are divided into, wherein, osi layer model in particular show the reference model or symbol of the communication system independently of manufacturer
Close the communication protocol of iso standard and the design basis of computer network.Osi layer model is constituted by 7 layers：
Layer 7：Application program：The input and output of the function and data of application program.
Layer 6：Demonstration：The data that will be independent of system are converted to format independent.
Layer 5：Communication：Control connection and data exchange.
Layer 4：Transmission：Packet is associated with application program.
Layer 3：Network：Route a data packet to next node.
Layer 2：Safety：Verification is segmented and added to the packet in frame.
Layer 1：Bit transfer：It is the signal for being suitable for medium and physical transfer by bits switch.
Specific function is performed in every layer of communication that must be between the two systems.For every layer, defining must be two
The function and agreement of particular task are performed in communication between individual system.In communication between the two systems, communicate or data
Stream especially travels through all 7 layers of (run through) osi layer model twice.Once occur in transmitter, once occur connecing
Receive device.According to communication lines by including how many intermediate stations, communication also repeatedly travels through the layer model.In this respect, agreement is OSI moulds
The regular set communicated in the early certain layer of type.The terminal installation and transmission medium of terminal system are arranged from osi model
Remove.However, the transmission medium in the terminal installation and bit transmission in application layer can be predefined.The agreement of one layer is special
Ground as much as possible transparent to the agreement of their the upper and lower, thus in the situation of the both sides' direct communication on opposite side
Under, present the behavior pattern of agreement.Transformation between layer can interface in particular, it must be understood by agreement.Due to certain
A little agreements have been exploited for quite specific application program, thus also there occurs that protocol extension extends and cover to multiple layers
Multiple tasks.It is even possible that, in some aspects, each task is performed a number of times.
Term SCADA is usually directed to monitoring, visualization and/or control or the setting of the whole concentration/decentralized system of regulation.Greatly
Majority regulation is held automatically by remote-terminal unit (RTU) or programmable logic controller (PLC) (referred to as PLC) or 1 grade of automation mechanized operation
OK.The target of 2 grades of automation mechanized operations is 1 grade of function of automation mechanized operation of optimization and exports manipulating variable and desired value.The opposing party
Face, 3 grades of automation mechanized operations are used to planning, quality assurance and/or filing (documentation).
Communication in SCADA system can be carried out according to the Internet technology based on TCP, wherein, point-to-point communication and/or
One or more serial connections of field bus system form are possible.
The state that Data Detection is detected generally since rank 1 and including the connection with measurement apparatus and by SCADA system
Information, such as position of the switch.Then, data are present in user-friendly display and perhaps to control purpose and intervene
Process.
SCADA system is typically implemented the distributed data base comprising data point.Data point is included by system monitoring and/or control
The input of system or output valve.Data point can physically be calculated.Physical data point constitute input or export, and the point for being calculated by
Mathematical operation from system mode is produced.Data point is usually seen as the group of the numerical value with timestamp (time stamp)
Close.Volume of data point makes it possible historical evaluation.
In such a case, it is possible to the temporal correlation of the data point from multiple unit 135A-N is advantageously used, with
Detection respective counts strong point or the relation of measurement data.This is advantageously allowed users to based on the measurement with time correlation mode
The display of data produces corresponding influence on process, such as by setting the triggering etc. of corresponding procedure parameter, specific operation.
Each temporal correlation includes moving horizontally or being aligned for the measurement data of unit 135A-N, thus measurement number
According to can be relative to each other by any way.
One unit 135A-N or device unit particularly including at least one reactor (for example, at least one bioreactor
And/or at least one chemical reactor), at least one sensor 140A-N and alternatively one or more individually control it is single
Unit and process apparatus.From the point of view of logic viewpoint, each unit 135A-N is used as the overall part that may be constructed production facility, example
Such as in for the process units for producing yeast culture, one or more procedure activations can be carried out in the process units.
Each unit 135A-N produces measurement data, the measurement data to be detected by sensor 140A-N and alternatively in preset time by list
Individual control unit detection, is preferably only limitted to a batch data.Each unit 135A-N can be independently of any other unit
135A-N is acted.Therefore, by means of each unit 135A-N, specific (i.e. predetermined or can be predetermined) process can be presented,
Thus can be by means of at least one sensor 140A-N detections simultaneously while all needed for showing process record or process monitoring
Measurement data.According to detailed process, each unit 135A-N can be assembled individually by the necessary process from said modules.
Or or in addition to reactor, unit 135A-N especially can be used for filter medium including at least one
Filter.For example, this can be the filter for cross-flow filtration or tangential flow filtration or transverse stream filtering, wherein, for example
Filtered for food and/or the liquid of pharmaceuticals industry.In this case it is necessary to the suspension of high-rate fitration parallel to film or
Filter medium by pumping, wherein, solid material or penetrant are laterally with respect to flow direction and are extracted.For example, intersection flows through
Filter can be used for microfiltration, ultrafiltration, nanofiltration, gas separation, pervaporation (pervaporation) and/or counter-infiltration.This
Each in a little unit 135A-N includes at least one sensor 140A-N and alternatively one or more single controls
Unit and process apparatus.From the point of view of logic viewpoint, each unit 135A-N may be constructed a part for production facility as entirety,
In the water treatment plant of the heavy metal for example in for removing water process, wherein one or more treatment activities can be carried out.
Each unit 135A-N produces measurement data, the measurement data to be detected by sensor 140A-N and alternatively in preset time by list
Individual control unit detection, is preferably only limitted to a batch data.Each unit 135A-N can be independently of any other unit
135A-N is acted.Therefore, specific process can be presented by means of each unit 135A-N, thus can be by means of at least one
All measurement data needed for sensor 140A-N detections and simultaneously display process record or process monitoring.According to detailed process,
Each unit 135A-N can be assembled individually by the necessary process from said modules.
Especially, sensor 140A-N is technology component, and the technology component can be detected quantitatively as measurand
The specific biology of its environment, biochemistry, chemistry and/or physical property.In this case, biology, biochemistry, chemistry
And/or physical property is converted into electricity and/or optical signal.Then electric signal can be scanned.In such a case, it is possible to be each
Biology, biochemistry, chemistry and/or physical characteristic generation digital measurement data or digital measured value.Therefore, sensor
140A-N can produce the data flow of corresponding measurement data.
Especially, each unit 135A-N have at least one sensor 140A-N, the sensor its be designed to detection
Relevant with process specific (i.e. predetermined or can be predetermined) measurement data.In this case, for example, sensor can be
Gas sensor, such as O2Or CO2Sensor, pH sensors, glucose sensor, lactate sensor and/or sensor appoint
What is combined, and these sensors are designed to the suitable measurand of the process that detection will be performed.Additionally, each unit
135A-N alternatively has one or more single control units.
As the bioreactor or fermentation tank 225 of the specific embodiment of unit 135A-N (following article is on described in Fig. 2)
Particularly a kind of container for being designed for culture or fermented cells, microorganism and/or plantlet.It is raw in bioreactor 225
Thing process (such as bioconversion or living things catalysis) can be used in technique device or in technique device being useful.This
In the case of, it is intended to by means of in bioreactor 225 controlled key factor optimal condition of culture can be obtained.It is controllable because
Element may, for example, be the combination of nutritive solution or the combination of matrix (substrate), oxygen supply, aseptic or pH value.Biological respinse
The purpose cultivated in device 225 can be obtained cell, obtain cell component or obtain metabolite or metabolin, then can be by
It is used for example as the active material in pharmaceuticals industry or the basic chemical in chemical industry.The example of this bioreactor can
With e.g. can autoclaved bioreactor, in situ bioreactor (the in situ serializable that can be connected
Bioreactor), disposable bioreactor, stirred tank reactor, fixed bed reactors or bioreactor.And, wine
The production of essence or alcoholic beverage (such as beer) can be carried out in bioreactor (such as brew kettle).Especially, it is biological anti-
Device is answered to be not subject to any specific restrictions.They for example include that (such as bacterium, yeast, insect, plant or lactation are moved for cultured cells
Thing cell) bioreactor, the bioreactor of metabolite for producing such cell, for producing by such
Cell expression peptide or protein matter bioreactor, by means of this cell produce energy bioreactor, by means of this
The bioreactor of kind of cell proliferation virus, the bioreactor by means of such cell disintegration material, by means of this thin
The bioreactor of born of the same parents' production food, bioreactor of generation biogas and combinations thereof with the help of these cells.
Single control unit 230 (as described in following reference picture 2) is technical parts, and it can be sensor 140A-N, n
Individual actuator (actuator), pump, counter or adder (totalizer) and any suitable processing unit.Especially,
Single control unit 230 can also be any combination of above-mentioned technical parts, also referred to as control module, and it can serve as a list
Unit, such as circulating pump, servo control mechanism, control device feed back information to the pneumatic linear actuator of control unit.Additionally, single control is single
Unit 230 can be made up of multiple individually controller units, for example ,/delivery valve control module or ON/OFF are automatically entered by multiple
The main control module that the combination of automatic stop valve is constituted.Therefore, single control unit 230 may, for example, be：
- adjusting means, it is by transmission unit or transmitter, adjustment unit or controller and regulating valve or controls valve to constitute；
- towards the device of condition (condition-oriented), it include entering automatically with position feedback switch/
Go out valve control module, it can be operated and/or be controlled by the theoretical value of device；Or
- head (header), it includes automatic feeding/discharging valve control module, and coordinates the valve, described to flow through
The flow velocity of valve reaches one or more targets.
Especially, control module 325 (as described in below with reference to Fig. 3) includes particular variables, and the particular variables belong to together
Physical measurement or calculating value.Control module can also alternatively control or adjust the variable.Can provide different types of
Control module：Controller, process variable, numerical variable and/or offline variable.
Each device 205,210,215 (as described by below with reference to Fig. 2) is especially constituted for connecting the member to
The interface of unit.For example, sensor device 205 may be constructed for by O2/CO2Analyte sensors are connected to the interface of the unit.
Additionally, reactor assembly 210 may be constructed the interface for connecting bioreactor 225.Equally, single control unit device
215 may be constructed the interface for ratio control unit to be connected to unit.
Especially, batch data (batch) is the compilation of data or data set, and the data are specific (i.e. predetermined or can
It is predetermined) detected by the corresponding assembly of unit as measurement data in the time period.Especially, batch data data are by means of mistake
The record of the measurement data of journey, it can be performed by unit and therefore can also filed (archive).Each batch data
Data can be stored in database after process terminates.Therefore, it can be repeatedly used analysis and/or assess.Therefore, often
Individual batch data is repeatedly included in the unique process steps run in same time period.Data or data set can be by defeated
Go out unit to store and show with the time according to its order continuously collected.For example, each batch data can be in unit (for example
Reactor or bioreactor) filling and complete empty the unit between time period in include all measurement data, its
Specifically it is detected after (such as predetermined or can be predetermined) time period (such as reaction time or growth time).
Measurement data or process data especially comprising the information relevant with the value of the attribute in preset time data or
Data set.Measurement data can be stored in database.
Material can be particularly liquid, gas and/or solid.The material can be by least one in order to carry out the mistake
Component composition required for journey.Thus, for example, in order to cultivate specific microorganism (such as particular portion of cell or microorganism
Point), it may be necessary to produce and maintain to ensure the essential condition of microorganism optimum growh.For example, such essential condition can be with
It is the aseptic in the combination of nutrient medium or the combination of nutritive solution or the combination of matrix, pH value and/or bioreactor.
The purpose of culture can collect microorganism (part of such as cell and microorganism).Another purpose of culture is to be metabolized
Product, it can be used as active material in pharmaceuticals industry and/or be used as basic chemical in chemical industry.Additionally, the mesh
Can be chemical decomposition composition (such as in sewage treatment plant) or production alcoholic beverage.
Measurement data 335 (referring to referring to Fig. 3) can show via display unit 100, such as with experiment curv
Form shows.Used as the replacement to this and/or supplement, measurement data can be shown in the form of one or more figures, for example
Pie chart, lines figure, bar chart, organization chart, Gantt chart, flow chart, cause-and-effect diagram and/or block diagram.
In order to optimization process (such as cell culture), it is necessary to which accurately (such as oxygen contains the key factor of general introduction process
Amount).Additionally, it is important that obtain the relevant information of change with successful these factors of influence process, another aspect, for example with
Influence cell growth relevant by oxygen supply or the new nutrient medium of addition.This can be realized in an efficient way, such as two
Individual process is run in different units 135A-N simultaneously in the case that, two units are shown by with corresponding temporal correlation
The measurement data of the sensor 140A-N of 135A-N so that intrinsic relation is believed in the measurement data shown by being based on
Breath.Each component of computer system 160 can be via suitable network 145 (such as " LAN " (LAN) or " wide area network "
(WAN)) it is connected to each other.
Alternatively, computer system 160 can include detection unit 150, and it is related that it is designed to automatically recognition time
Property.For example, detection unit 150 can each other be compared to the measurement data stream of unit 135A-N, and correspond to each other
Measurement data can be independently of the absolute time of the detection of the measurement data stream, by means of being located in the way of time correlation
The display unit 100 of corresponding viewing area 105,110 shows.
The temporal correlation of measurement data can be recognized by any way, basically as the function of corresponding application program
And its purpose or purpose.For example, the measurement data of different units
- above or below one or more are specific (i.e. predetermined or can be predetermined) absolute value or threshold value and/or one
Or multiple relative values, such as pH value, CO2Value or O2Value；
- correspond to the highest or floor level for measuring；
- correspond to specific (i.e. predetermined or can the be predetermined) increase of curve, can for example represent growth rate；
- correspond to specific (i.e. predetermined or can the be predetermined) reduction of curve, can for example represent the death rate；
- alarm is particularly corresponding to, if it exceeds or less than for corresponding biology, biochemistry, chemistry and/or thing
The essential condition of reason process, then can trigger alarm, if for example the pH value of oxygen content and/or the material in reactor is too
It is low or too high.
- correspond in being described property univariate data (such as distribution inspection, distributed constant calculating, graph data
Analysis or correlation analysis) after measurement data each variable between specific (such as predetermined or can be predetermined) it is related
Property；
- there is specific (i.e. predetermined or can be predetermined) packing density after principal component analysis (PCA) is carried out；
- have specifically after PLS (PLS) and/or discriminant analysis and/or cluster analysis is carried out
Structure or classification in (i.e. predetermined or can be predetermined) data；And/or
- after the method for performing senior multivariate data analysis (such as multiway principal component analysis), with specific
Structure in (i.e. predetermined or can be predetermined) data.
Alternatively, or in addition, user can be by means of suitable input unit (such as keyboard and/or computer mouse)
Mark is set in the measurement data stream of display.The temporal correlation of measurement data can be recognized on this mark.
Or or in addition, each batch data can be divided into the different stages.For example, the first stage can correspond to material
Be introduced into unit, second stage correspond to cell is added in material, the phase III correspond to other cell is added to
Material is medium.In this case, because the measurement data of different units corresponds to the beginning of moment, thus can recognize
The temporal correlation of measurement data.
This this have the advantage that, after specific (i.e. predetermined or can the be predetermined) condition of satisfaction is automatically compared, respectively
The absolute time that the measurement data of individual unit 135A-N can be detected independently of it automatically shown by display unit 100, from
And information can be obtained based on relation intrinsic in the data.
Alternatively, computer system 160 can include control module 155, and the control module 155 is designed at least two
Individual unit 135A-N is combined in groups, such that it is able to pass through control module 155 while controlling the group (such as below with reference to Fig. 4).
Especially, computer system 160 this have the advantage that, can in real time detect difference in simple and efficient mode
Important process factors influence or the change of one or more process factors.Therefore, it can carry out process workflow
Filled function or improvement.Especially, settable when process is specifically run on corresponding unit 135A-N or input biology,
Chemical, biochemistry and/or physical process parameter and the procedure parameter can be achieved in as the function of the corresponding state of process
Improved, continuous user/machine interaction.As a result, so that the coordination of technical operation in corresponding units 135A-N or tune
Be possibly realized.
Additionally, different technologies state present in unit 135A-N can be shown by means of display unit 100.
Especially, if it exceeds or less than for corresponding biology, biochemistry, chemistry and/or physical process being
Important condition, such as it is too low or too high if located in the oxygen content and/or pH value of the material in reactor, then can be by aobvious
Show the display alarm of unit 100.
Further, since parameter necessary to each process can be in real time set in each process workflow, therefore energy
It is enough that technical controlling is carried out to unit 135A-N.
Another advantage is, by means of temporal correlation, can be independently of detected measurement data by display unit 100
Absolute time access the technical relation of the process in unit 135A-N.Additionally, temporal correlation can be in corresponding units
Kept during the duration of the various process of 135A-N.
Therefore, user can more effectively and quickly management and monitoring technical parameter, control technology procedure parameter, detection be each
Intrinsic technical relation and the influence of process workflow of each technical parameter to unit 135A-N is monitored during kind
Technical assignment.
Fig. 2 is the structured flowchart of the embodiment of unit 200.Especially, unit 200 includes reactor 225 or filter, its
It is designed to receive material or material, to perform at least one biology, biochemistry, chemistry and/or physical process.Additionally,
Unit 200 has sensor 220, such as O2/CO2Analyzer, it is configured as the detection measurement data related to process.Additionally,
Unit 200 includes single control unit 230, such as ratio control unit and/or one or more internal individually control units
235.Each internal individually control unit 235 can be configured as performing the calculating related to the measurement data for detecting, and/or
Obtain and/or analyze the material sample that the process is carried out on material sample.
Each in these components can be connected by means of corresponding device 205,210,215 with unit 200.Each dress
It can be communication interface to put 205,210,215.Unit 200 and device 205, the separation between 210,215 have advantages below：It is single
The arrangement of unit 200 can be performed in a simple and effective way, because can be by device 205,210,215 by corresponding part
220th, 225,230 it is connected with unit 200.Especially, O2/CO2Gas analyzing apparatus 220 can be by USB (USB)
It is connected with unit 200, wherein, sensor device 205 is used as communication interface.For example, bioreactor 225 can be via Ethernet
By corresponding measurement data be sent to unit 200 and/or with the further exchange data of unit 200, wherein, reactor assembly 210
Can serve as communication interface for the purpose.Ratio control unit 230 can be by single control unit device 215 and list
Unit 200 connects.The independent control unit 235 in inside of needs alternatively can be connected with unit 200.
Control module 325 (as described by below with reference to Fig. 3) can merge variable, and the variable belongs to by sensor 220
Physical measurement or calculating or determination value.Control module 325 can also alternatively control or adjust variable.Difference can be provided
The control module 325 of type：Controller, process variable, numerical variable and offline variable.For example, unit 200 can include being used for
The temperature sensor of detection temperature.Control module 325 corresponding to temperature sensor can be provided.The control module 325 can be with
It is controller noted above type.In the present embodiment, control module 325 can have following variable：
The temperature value of-Temp.Value → reality；
- Temp.Setpoint → desired temperature value；
- Temp.Output → temperature output variable；
- Temp.Mode → (temperature model, for example automatically, manually, configuration file (profile), tandem (cascade)；
- Temp.Status → state of temperature, for example remotely, closes.Whether state value can be described in detail can write this
Value.The state value constitutes security function；
-Temp.Value.EngineeringUnit→℃；
- Temp.Output.EngineeringUnit → %；
- Temp.HighLimit → (specify high limit temperature threshold；If it exceeds specific (i.e. predetermined or can be predetermined)
Value, then can export alarm；
- Temp.HighHighLimit → and when more than the absolute temperature upper limit, triggering alarm；
- Temp.LowLimit → specify relatively low temperature threshold；If it exceeds specific (i.e. predetermined or can be predetermined)
Value, then can export alarm；
- Temp.LowLowLimit → and when less than absolute temperature lower limit, triggering alarm；
The ID of-Temp.UnitID → designating unit 200, placed control module 325 on the unit 200, therefore, each
Control module 325 can be clearly allocated.
The MappingShortID of oneself can be distributed for each control module variable.This this have the advantage that, accordingly
Input measurement data can be explicitly assigned to control module variable.
Fig. 3 illustrates the structure and the embodiment of relation of the measurement data 335 of the unit 320 for being incorporated to batch data 350.
In this case, from the point of view of the visual angle 305 that communicates, can be led to each unit 320 via control module 325
Letter.Each control module 325 can include control module variable 330.Control module can be belonging to the variable or value of physical quantity
Summary (summary).Each control module has at least one value (such as 34.5), entity (such as DEG C), unit and " source "
(original device of the calculating of value or value).Alternatively, control module can include supplementary variable (such as desired value, output variable
And/or LowLimit or alarming limit).Additionally, viewing measurement data 335 is possible.From user perspective 315 or monitoring visual angle
See, each control module 325 is assigned to associated unit 320 and there can be one or more control module variables 330.
In trend, with display control module variable, but can be not all of, but only show actual value, desired value and/or output variable
Type.One or more measurement data 335 can distribute to each control module variable 330.User perspective shows unit
320 current effective configuration.Control module can have multiple variables according to type.However, only one of which measurement data/
Measured value can distribute to each variable.
From history batch data visual angle 340, the measurement data is stored in batch by the batch processing of each unit 320
In data 345 (measurement data memory 370).In this case, when starting and stop, start and stop time 350 is divided
Dispensing each batch data 345.The batch time started correspond to record beginning while corresponding to the biology on unit/
The correlation of chemical process starts.Batch dwell time corresponds to the corresponding of biology/chemical process and terminates while corresponding to note
The end of record.The control module 325 and its control module variable 330 that are configured during batch starts and the accumulation during process
Measurement data 335 also respectively, may be stored at batch data 345.Therefore, each batch data 345 is stored with the currently active matching somebody with somebody
The brief description and all measurement data or process data put.
This has advantages below：Can consider in analyzed area or analyze complete/batch data of history and its work as
Preceding effective configuration.Meanwhile, by management, computer system 160 allow using be each device or device 205,
210th, the structure of 215 new/different/modification (new or modification device, the unit of renaming, modification on unit
Control module title, the unit deleted).User or monitoring visual angle make it possible to the measurement data of monitoring unit 320 or cross number of passes
According to.History batch data visual angle makes it possible to achieve measurement data and/or analysis (particularly its off-line analysis).Communication visual angle
Make it possible to display measurement data stream and distribution measurement data.Batch data 345 and associated process data can be stored
In database.The data can be derived as CSV (comma separated value) files from SQL database, be made with other instruments
With.Effective data compression can be realized preferably in database.This this have the advantage that, is carried in response to corresponding database
Take (retrieval), the measurement data of storage can be with the interval speedy carding process of short time.
For example, measurement data can be made up of following variable：
- MappingShortID → identification control module variable；
- Timestamp → timestamp：When unit 320 receives measurement data, computer system 160 can be every
Issuing time stamp in individual measurement data item collection, to obtain optimum precision；
The measured value of-Value → measurement data；
- Quality → binary value, such as 0 represents " good ", and 1 represents " bad "；Quality may determine whether single by showing
Unit 100 shows measurement data；
- Checksum → produced by computer system 160, to prevent data manipulation.Its advantage is to increase computer system
160 security.
For example, due to two unit 135A-N combination 400 (unit packets), the detection list in computer system 160 in groups
150 (as mentioned above for described in Fig. 1) of unit can show temporal correlation.
Fig. 4 illustrates the embodiment of the group 400 of at least two unit 405A-N.In the case of packet, this and unit
It is unrelated that there is 405A-N same type still to have identical sensor 420A-N or single control units 430A-N.
Therefore, system realizes free location packet assembling, wherein, detection unit 150 can show temporal correlation.
In this case, the connected mode of all parts of unit 405A-N is similar to the connected mode described in Fig. 2, i.e. sensing
Device 420A-N is connected by means of corresponding sensor device 406A-N with corresponding units 405A-N.Reactor 410A-N can be by
Connected with corresponding unit 405A-N in corresponding reactor assembly 410A-N.Each control unit 430A-N can be by means of phase
The single control device 415A-N for answering is connected with corresponding unit 405A-N.Corresponding individually control unit 435A-N can be with
Alternatively connected with corresponding unit 405A-N.
In this case, otherwise in public viewing area or alternatively can be by corresponding dedicated display area
The measurement data of each batch data is exported in display unit 100.In this case, computer system 160 include three or
More units 405A-N, can be formed group 400, the group 400 by time correlation unit 405A-N arbitrary optional combination
Composition.Additionally, by means of corresponding display unit 100, different users can individually produce any group 400 so that can be with
Start or perform the corresponding temporal correlation with 400 corresponding measurement data of group.Furthermore, it is possible to pass through to be input into corresponding life
Order, such as, by activating " report " button, produced by each user and stored the brief description of measurement data, and the measurement data is led to
Display unit 100 is crossed to be shown with corresponding temporal correlation, thus user can at any time access the number with time correlation
According to.When process is currently running, each group 400 either automatically or manually can also again be decomposed by user, such as special when meeting
During fixed (i.e. predetermined or can be predetermined) condition.
In the case where unit is grouped, by the respective process of reactor and/or filter and alternatively corresponding attached
Plus individually control unit and internal individually control unit, the measurement data of each sensor is combined into corresponding discrete batch number
Shown according to and by display unit 100.
Due to the specific density more than data or data set, it is impossible to show combination one simultaneously by display unit 100
The all data for rising, computer system 160 can include default value, and display unit 100 always shows according to the default value
Last, nearest N number of data that are detecting and being added to batch data or data set, wherein, N defines data or data set
Specific (i.e. predetermined or can be predetermined) quantity.
When specific (i.e. predetermined or can be predetermined) ratio is applied to the measurement data of unit 405A-N, can be with
Display temporal correlation, so, the absolute time that the measurement data in time window is detected independently of it is with time correlation
Property shows.In this case, even if new measurement data is included in the batch data, this time phase of measurement data
Closing property or synchronism can also be retained in display unit 100.Display unit 100 can show the data in time window
Temporal correlation.Especially, due to being displayed in viewing area or display window in change (particularly quilt according to its ratio
Compress or be expanded) measurement data it is relevant with the measurement data being displayed in the second viewing area or display window, thus together
Step property can be the temporal correlation of specific type.
This has advantages below：Detected independently of it by the measurement data of two sensor detections of unit and time correlation
Absolute time shown via time window.In this case, detected by sensor and be added to corresponding batch data
New data or data set are not shown by display unit 100.
In another implementation, due to via the sensor of unit 405A-N with the survey of different time interval measurement
Amount data time correlation each other, thus temporal correlation can be shown.Especially, it is applied to the time window of corresponding batch data
Size can change in this way, i.e., measurement data corresponds to each other in its time interval.Temporal correlation can
Selection of land is set manually by user.
Fig. 5 illustrates the embodiment for simplifying display on display unit 500, wherein, provided in upper display area 505
First zoom control 525 that can be provided by the first scaling bar 515.By this way, time window can be applied to first
The measurement data 335 of batch data, hereinafter also referred to trend.Because the first zoom control 525 is not adjacent to right hand edge, thus top
Trend shows the measurement number of the batch data from selected time window independently of the absolute time of the detection of measurement data 335
According to.The measurement data 335 of another unit is shown in the second viewing area 510, wherein, can be by means of the second scaling bar 520
Mobile second zoom control 530.In this case, due to the whole time period of two trend be it is very different, thus two
The measurement data of unit is impossible synchronous.
User can be located at by control by means of suitable input unit the point browsed on outer scaling bar 515,520 come
The width (a multiple measurement data to be shown 335) of control time window.Therefore, positioned at the controlled end browsed of side
Portion extends towards the point.
Specifically, by means of suitable input unit, user can increased or decrease the width browsed and in scaling bar
515th, arbitrarily to the right and thumb is moved to the left in 520.
Fig. 6 illustrates the embodiment of the action that only there may come a time when.Specifically, Fig. 6 is illustrated by means of the first viewing area
The first measurement data stream or trend of the display of display unit 600 in domain 605.Zoom control 625 be located at scaling bar 615 in most
Left side.This may mean that the first measurement data 335 for for example showing corresponding batch data 345.Second measurement data stream shows
In the second viewing area 610, wherein, zoom control 630 is located at the rightmost of corresponding scaling bar 620.The two trend can
Linked each other with by means of corresponding button 635.In such a case, it is possible to pass through to reduce corresponding zoom control 625,630
Ratio come perform including reduce regional percentage action.However, because top zoom control 625 (reactor) is adjacent to
The left hand edge of two scaling bars 610, thus the movement of bottom zoom control 630 can not possibly be towards the left side.Referring to Figure 10 descriptions
The embodiment of the realization of the function.
Fig. 7 respectively illustrates two measurement data streams, wherein, the synchronization of time shaft is possible, wherein, Fig. 8 is illustrated
The synchronous result of time shaft.
Specifically, Fig. 7 illustrates display unit 700, which show the first module 135A-N in the first viewing area 705
The first measurement data stream and the second viewing area 710 in second unit 135A-N, 200,320 the second measurement data
Stream.Corresponding zoom control 725,730 has identical size and in the same area of specific scaling bar 715,720.
Two measurement data streams can be synchronous by activating corresponding button 740.Below with reference to the reality of Fig. 9 interpretation techniques
It is existing.
Fig. 8 illustrates latter two measurement data that synchronization is activated on the basis of activator button 740 (Fig. 7) shown in Fig. 7
Stream.Especially, the fluctuation of the corresponding measurement data in each viewing area 805,810 or change shows with being clocked in relation to each other
Show, i.e., shown with same or analogous interval.In this case, the zoom control 830 of the second display unit is relatively large
Ratio is reduced, thus less measurement data is shown in corresponding viewing area 810, so as to simultaneous display is surveyed
Amount data.In this case, it is a problem that the run time of which batch data is more long.Therefore, certainly it is possible that bottom
Or the ratio of top trend or scaling bar reduces.
Fig. 9 illustrates process flow diagram flow chart, and it has visualized the scaling bar 715,720,815,820 as described in Fig. 7 and Fig. 8
Synchronizing process.The embodiment realized by means of corresponding method is explained in detail the process.First, user can start 905 and (make
Scaling bar synchronization), make two scaling bars 715,720,815,820 synchronous by means of corresponding activation, such as by activating Fig. 7 in
Button 740 or Fig. 8 in 840, hereinafter also referred to " synchronization " button.For example, can be by " binding " and order
" SynchTrendsCommand " link " synchronization " button in WPF (Windows Presentation Foundation), such as
Be can be seen that from implemented below example：
Order " SynchTrendsCommand " can be in the pattern-view, view of class " TrendDisplay ", i.e. trend
Pattern (Model View ViewModel, MVVM), middle implementation.MVVM is pattern-View-Controller pattern (Model View
Controller pattern, MVC) variant, it is used to separate the display of user interface and logicality, and by UI platforms
WPF is supported.
By means of two methods " trend synchronization " (OnSynchronizeTrends) 935 and/or " can make trend
It is synchronous " (OnCanSynchronizeTrends) 910 realize order.Especially, the method in classification " display trend " " becomes
Gesture synchronization " 935 can be with access synchronized.On the other hand, whether method " can allow trend synchronization " 910 checks synchronous possibility.
Therefore, it can activate/enable or disable/disable " synchronization " button：
Method " on trend synchronization can be made " 910 can with so that access level " scaling bar manager "
(ZoombarManager) internalist methodology " making the synchronization of scaling bar " (SyncZoombars) 940, two of which scaling bar conduct
Configured transmission：
Similarly, method " can make trend synchronization " can internally from classification " scaling bar manager ", access method " can
So that the synchronization of scaling bar " (CanSyncZoombars) (Fig. 9 is not shown), two of which scaling bar is used as configured transmission：
Explained later determine two scaling bars whether the embodiment that can synchronously realize：
Specifically, when method " synchronization of scaling bar can be made " internally access method " acquisition locking range "
(GetSynchronizedRanges) determination can be realized, the method is also using two scaling bars as the transmission that passes a parameter.
In this case, especially, the tuple (tuple) of X-axis or the timeline (timeline) of batch data and scaling bar scope
Tuple can be transmitted as return value.If the return value is " zero ", cannot synchronize, and button keeps disabling or prohibits
With.If tuple of the return value comprising accordingly effective attribute (X-axis and scaling bar scope), the scaling bar that inspection will be changed
Minimum zone whether be less than the scope to be set.If it is the case, lockage button will be activated：
Method " making the synchronization of scaling bar " 940 can with so that internally access method " acquisition locking range " 945, two of which
Scaling bar is used as configured transmission.In such a case, it is possible to set mark (in " in synchronous behavior " in advance
SyncAction), to prevent other processes or action during this period.Tuple (X-axis and zoom ranges) can be again method
Return value.If value is " zero ", any operation is not performed.If tuple includes effective object in different situations,
Set what is changed with the value (" setting relative Repeat " (SetRelativeRange) 965, referring to Fig. 9) (relatively) for being provided
Scale the scope of bar, i.e. minimum zone value and maximum magnitude value：
In this case, relative Repeat is relevant with trend, and independently of its absolute time.In this respect, it is possible to implement
Method " acquisition locking range ", its X-axis access profile from transmission：
ZoombarRange zoombar1Range=zoomableXAxis1.GetRange ()；
ZoombarRange zoombar2Range=zoomableXAxis2.GetRange ()；
In addition, calculating absolute time section.This has advantages below：Compared by means of the minimum value or maximum of respective range
More different scaling bars：
Var zoombar1RangeSpan=(zoombar1Range.Maximum-zoombar1Range.Minimum) *
(zoomableXAxis1.XAxisEnd-zoomableXAxis1.XAxisStart)；
Var zoombar2RangeSpan=(zoombar2Range.Maximum-zoombar2Range.Minimum) *
(zoomableXAxis2.XAxisEnd-zoomableXAxis2.XAxisStart)；
In a subsequent step, the time period that can compare each scope, which was bigger.Therefore, it is necessary to differently calculate will
Change the scope of (adapt)：
Range.Minimum=zoombar2Range.Minimum
Range.Maximum=zoombar2Range.Minimum+RelativeChangeOfSeco ndZoombar
(zoombar1Range.Maximum–zoombar1Range.Minimum,zoomableXAxis1,zoomableXAxis2)
Can by means of method the relative changes of bar " second scaling " (RelativeChangeOfSecond Zoombar),
With |input paramete " relative changes of scaling bar " (RelativeChangeOfZoombar), the first scaling bar
(firstZoombar), the second scaling bar (secondZoombar) realizes " maximum magnitude " (Range.Maximum)：
Application way " relative changes of the second scaling bar " (Relative Change Of Second Zoombar) 960
(Fig. 9), can as follows realize the calculating of " maximum magnitude " (Range.Maximum) of the second scaling bar：
Figure 10 is illustrated, and is explained as explained above with Fig. 7 and Fig. 8, visualization link scaling bar 715,720,815,820
Process flow diagram flow chart.The process is explained in greater detail by the implementation method of corresponding method.First, user can start 1005
(link scaling bar), by means of corresponding activation (for example by activating 835 in button 735 or Fig. 8 in Fig. 7, below also referred to as
It is " link trend switch key " (LinkTrendsToggle) button) link two scaling bars 715,720,815,820 or release
Two links of scaling bar 715,720,815,820.For example, can be by being tied to boolean properties " trend link "
(AreTrendsLinked) " link trend switch key " button binding, such as can be seen that from following implementation example：
In such a case, it is possible to determine the whether linked boolean properties of corresponding trend (Boolean property)
" link trend " (AreTrendsLinked) can be linked to dependency attribute (Dependency Property) " trend and attribute
Link " (AreTrendsLinkedProperty) ", it passes through corresponding activation " link trend switch key ", and button can be with access side
Method " link trend " (OnAreTrendsLinked) 1010, from following examples it can be seen that：
If trend is linked, method " in link trend " (OnAreTrendsLinked) can be with access method " solution
Except the link of scaling bar " (UnlinkZoombars) 1020.If trend is not linked, method " in link trend " can be corresponding
Ground access method " link scaling bar " 1035.In this case, the boolean state of boolean properties " link trend " can be corresponding
Ground modification.Followed by implementation method " link scaling bar " (LinkZoombars) and the example of " releasing the link of scaling bar "：
When access method " link scaling bar " 1035, (subscribe) event " scaling bar changes notice " can be subscribed to
(OnZoombarChangedNotification) 1040 " subscribe to scaling bar and change notice "
(ZoombarChangedNotificationSubscribe), and can by 1045 with method " open action link "
(PublishActionLink) 1065 (scaling bar is linked) link.Event " scaling bar changes notice " and method are " open dynamic
Link " can be as each zoom control be along each mobile accessed of each scaling bar.In the method, it is " open dynamic
Link " user can be realized by means of single zoom control to control two functions of time window.By means of the function, use
Family can be by the scaling bar of unit (actuator) 1050 (" changing scaling bar position " (ZoombarPositionChanged))
Move zoom control to control two time windows, so that correspondingly traveling time window.In this case, time window
Movement both can apply to the measurement data of actuator 1055 (" change first and scale bar " (ChangeFirstZoombar)),
Can apply to the measurement number of second unit (reactor) 1060 (" change second and scale bar " (ChangeSecondZoombar))
According to this is possible for two units (as described in above for Fig. 6).Followed by implementation method " open action link "
Embodiment：
When access method " releasing the link of scaling bar " 1020, can terminate again to event " scaling bar change is notified "
1025 (" do not subscribe to scaling bar and change notice " (ZoombarChangedNotificationUnSubscribe)) are subscribed to, thus
The movement of time window no longer influences other time windows 1030 (releasing the link of scaling bar).
With reference to Figure 11, describe to realize the embodiment of system of the invention.The embodiment of system includes conventional computer
The all-purpose computer unit of environment 20 (such as " personal computer " 20) form, the computer unit have processor unit 22,
System storage 24 and the system bus 26 of the multiple system components (especially system storage 24 and processor unit 22) of connection.
When system storage 24 is accessed, processor unit 22 carries out arithmetic, logic and/or control operation.System storage 24 can be with
Information and/or instruction that storage is used in combination with processor unit 22.System storage 24 can include volatibility and non-volatile
Property memory, such as " random access memory " (RAM) 28 and " read-only storage " (ROM) 30.Basic input output system
(BIOS) can store in ROM 30, the BIOS is for example passed between the element contributed in PCs 20 is included during starting
Deliver letters the fundamental conventions of breath.System bus 26 can be (especially memory bus or a storage in many bus structures
Device controller, peripheral bus and local bus), it uses a spy from multiple bus structures (bus architecture)
Determine bus structures.
In addition, PC 20 has for reading or writing the hard disk drive 32 of hard disk (not shown) and for reading or writing
Enter the peripheral driver 34 of moveable magnetic disc 36 or removable data storage medium.Moveable magnetic disc can be disc driver or
The floppy disk driver of disc driver or the CD (such as CD-ROM) of CD drive.Hard disk drive 32 and external disk
Driver 34 is connected by hard disk drive interface 38 and disk drive interface 40 with system bus 26 respectively.Driver and phase
The computer readable medium of association is that computer is other numbers of computer-readable instruction, data structure, program module and PC 20
According to offer nonvolatile memory.Data structure has the related data for realizing the above method.Although being retouched by embodiment
The environment stated has used hard disk (not shown) and outer disk 42, it will be apparent to those skilled in the art that in exemplary work
Making use in environment can store other kinds of computer-readable medium (the such as tape that computer may have access to data
Box, flash card, digital video disks, random access memory, read-only storage etc.) it is obvious.
Multiple program modules, particularly operating system (not shown), one or more application programs 44 or program module are (not
Show) and routine data 46, can store in hard disk, external disk 42, ROM 30 or RAM 28.Application program can include
At least a portion function as shown in Fig. 1 or Fig. 5 to Fig. 9.
As described above, user can will order and information by means of input unit (such as keyboard 48 and computer mouse 50)
It is input in PC 20.Other input unit (not shown) can include microphone and other sensors, control stick
(joystick), game mat, scanner etc..These or other input units can be by means of serial with what system bus 26 was connected
Interface 52 is connected to processor unit 22, or by means of other interface (such as parallel interface 54, game port or general serials
Bus (USB)) connection.In addition, information can be printed by printer 56.Printer 56 and other parallel input/output devices can
It is connected with processor unit 22 with by parallel interface 54.Monitor 58 or other types of display device (are such as regarded by interface
Frequency I/O port 160) it is connected with system bus 26.In addition to the monitor, computer environment 20 can include other peripheries
Output device (not shown), for example, loudspeaker or voice output device.
Computer environment 20 can be with other electronic installation (such as computer, telephone, wireless phone, individual digitals
Assistant (PDA), television set etc.) communication.In order to communicate, computer environment 20 can be operated in networked environment, be which used
With the connection of one or more electronic installations.Figure 11 illustrates the computer environment networked with remote computer 62.Remote computation
Machine 62 can be another computer environment (such as server, router, network PC, equivalent or peer device or other conventional nets
Network node), and including many or all above-mentioned all elements on computer environment 20.Logic connection as shown in figure 11
Including LAN (LAN) 64 and wide area network (WAN) 66.This network environment is typically office, corporate computer networks, inline
Net and internet.
When computer environment 20 is used in lan network environment, computer environment 20 can be by network inputs/output
End 68 is connected to LAN 64.If using computer environment 20 in WAN network environment, computer environment 20 includes modulatedemodulate
Adjust device 70 or other devices for producing communication via WAN 66.Modem 70 is total by means of serial line interface 52 and system
Line 26 is connected, and the modem 70 is internally or outside relative to computer environment 20.In a network environment, relative to calculating
The program module of the display of machine environment 20 or its part can be stored in remote memory device, and the remote memory device can
Accessed on remote computer 62 or from remote computer 62 or system a part.Additionally, with the above method and/or be
Other related data of uniting can be accessed or accessed from remote computer 62 on remote computer 62.
Label list：
20 computer environments
22 processor units
24 system storages
26 system bus
28 random access memory (RAM)
30 read-only storages (ROM)
32 hard disk drives
34 disc drivers
36 mobile hard disks
38 hard disk drive interfaces
40 disk drive interfaces
44 application programs
46 routine datas
48 keyboards
50 computer mouses
52 serial line interfaces
54 parallel interfaces
56 printers
58 monitors
60 video inputs/output end
62 remote computers
64 LANs (LAN)
66 wide area networks (WAN)
68 network inputs/output end
70 modems
100 display units
105 viewing areas
110 viewing areas
115 scaling bars
120 scaling bars
125 zoom controls
130 zoom controls
135A-N units
140A-N sensors
145 networks (LAN, WAN)
150 detection units
155 control modules
160 calculating for being used to control, detect, adjust and/or analyze biological, biochemistry and/or physical process
Machine system
Unit 200
205 sensor devices
210 reactor assemblies
215 single control unit devices
220 sensors, such as O2/CO2Analyzer or analyte sensors
225 bioreactors
230 single control units, such as ratio
The 235 single control units in inside
305 communication visual angles
310 devices
315 users/monitoring visual angle
Unit 320
325 control modules
330 control module variables
335 measurement data
340 historic batch data visual angles
345 batch datas
350 start and stop times
The unit of 355 batch storages
The control module of 360 batch storages
365 data set property sensors
The measurement data of 370 batch storages
400 groups
405A...N units
406A...N sensor devices
410A...N reactor assemblies
The single control unit devices of 415A...N
420A...N sensors
425A...N bioreactors
The single control units of 430A...N
The single control unit in 435A...N inside
500 exemplary display elements
First viewing area of 505 display measurement data
Second viewing area of 510 display measurement data
515 first scaling bars
520 second scaling bars
525 first zoom controls
530 second zoom controls
535 linking buttons
540 lockage buttons
600 exemplary display elements
First viewing area of 605 display measurement data
Second viewing area of 610 display measurement data
615 first scaling bars
620 second scaling bars
625 first zoom controls
630 second zoom controls
635 linking buttons
640 lockage buttons
700 exemplary display elements
First viewing area of 705 display measurement data
Second viewing area of 710 display measurement data
715 first scaling bars
720 second scaling bars
725 first zoom controls
730 second zoom controls
735 linking buttons
740 lockage buttons
800 exemplary display elements
First viewing area of 805 display measurement data
Second viewing area of 810 display measurement data
815 first scaling bars
820 second scaling bars
825 first zoom controls
830 second zoom controls
835 linking buttons
840 lockage buttons
905 synchronization scaling bars
910 on that can make trend synchronization
915 can make trend synchronization
920 can not be synchronous
925 can be synchronous
930 start lockage button
935 trend synchronizations
940 make scaling bar synchronization
945 obtain locking range
950 scopes are adapted to
955 scopes are not suitable for
The relative changes of 960 second scaling bars
965 set relative Repeat
970 scaling bars have identical scope
1005 links for releasing scaling bar
1010 link trend
1015 trend have been linked
1020 links for releasing scaling bar
1025 subscribe to scaling bar changes notice
1030 links for releasing scaling bar
1035 link scaling bars
1040 subscribe to scaling bar changes notice
1045 open action links
1050 scaling bar positions change
1055 change first scales bar
1060 change second scales bar
1065 link scaling bars
Claims (15)
1. a kind of computer for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process
System (160), including：
Unit at least two (135A-N, 200,320,405A-N), they are designed to receive material, in order in the material
On carry out at least one biology, biochemistry, chemistry and/or physical process；
Wherein, each described unit (135A-N, 200,320,405A-N) has at least one to be configured as detection and the mistake
The sensor (140A-N, 220,420A-N) of the measurement data (335) of Cheng Xiangguan；With
At least one display unit (100,500,600,700,800), by means of the display unit, described two units
The measurement data (335) of (135A-N, 200,320,405A-N) shows that the temporal correlation is permitted with respective temporal correlation
Perhaps information is obtained based on the relation between presented measurement data (335).
2. computer system according to claim 1, it is characterised in that also including detection unit (150), the detection is single
Unit is designed to：
Mutually compared by by measurement data (335) stream of unit (135A-N, 200,320,405A-N), during identification
Between correlation；With
Can independently of the absolute time of the capture of the measurement data (335), by display unit (100,500,600,700,
800) the corresponding measurement data (335) of display unit (135A-N, 200,320,405A-N).
3. computer system according to any one of the preceding claims, it is characterised in that when with special ratios
Between window when being applied to the measurement data (335) of unit (135A-N, 200,320,405A-N), it may be preferred to ground shows
Show the temporal correlation, so that the measurement data (335) in the time window is independently of the measurement
The absolute time of the detection of data is shown with temporal correlation.
4. computer system according to any one of the preceding claims, it is characterised in that the temporal correlation can be with
It is arranged to the function of user input.
5. computer system according to claim 4, it is characterised in that by means of each viewing area (105,110,
505,510,605,610,705,710,805,810) display unit (100,500,600,700,700) display in is described
Two measurement data (335) of unit (135A-N, 200,320,405A-N)；
Wherein, during setting, each viewing area (105,110,505,510,605,610,705,710,805,
810) in, corresponding time window is applied to measurement data by user by means of zoom control (825,830) in special time
(335), the zoom control (825,830) can each viewing area (105,110,505,510,605,610,705,
710,805,810) it is mobile along the measurement data (335) in.
6. computer system according to any one of the preceding claims, it is characterised in that also include：
Control module (155), the control module (155) be designed to by Unit at least two (135A-N, 200,320,
405A-N) combine in groups.
7. computer system according to claim 6, it is characterised in that the control module (155) be additionally designed to by
The time window in the measurement data (335) of unit (135A-N, 200,320,405A-N) is applied to link together, institute
Measurement data (335) is stated to be shown in corresponding viewing area (105,110,505,510,605,610,705,710,805,810),
Thus user can follow the described of unit (135A-N, 200,320,405A-N) by means of zoom control (825,830)
Measurement data (335) synchronously moves the time window, to control the time window.
8. computer system according to claim 6, it is characterised in that the control module (155) is designed to same
One time and independently of the absolute time, execution is carried out on the material of unit (135A-N, 200,320,405A-N)
Process.
9. a kind of computer for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process
The method of realization, including：
Unit at least two (135A-N, 200,320,405A-N) are provided, it is designed to receive material, so as in the material
On carry out at least one biology, biochemistry, chemistry and/or physical process, wherein, each unit (135A-N, 200,
320,405A-N) there is at least one sensor；
Sensor detects the measurement data (335) related to respective process；And
By display unit (100,500,600,700,800) with temporal correlation show described two units (135A-N, 200,
The measurement data (335) 320,405A-N)；
Wherein, the temporal correlation allows to obtain information based on the intrinsic relation in shown measurement data (335).
10. method according to claim 9, it is characterised in that also include：
Mutually compared by by the operation of the measurement data (335) of unit (135A-N, 200,320,405A-N), by
Detection unit (150) recognition time correlation；With
It is aobvious by display unit (100,500,600,700,800) independently of the absolute time for capturing the measurement data (335)
Show the corresponding measurement data (335) of unit (135A-N, 200,320,405A-N)；
Wherein, when the time window with special ratios is applied to the described of unit (135A-N, 200,320,405A-N)
During measurement data (335), it may be preferred to which ground shows the temporal correlation, so that described in the time window
The absolute time that measurement data (335) is detected independently of it is shown with temporal correlation.
Method described in 11. one in claim 9 or 10, it is characterised in that the temporal correlation can be set
It is set to the function of user input：
Two measurement data (335) of unit (135A-N, 200,320,405A-N) can by means of display unit (100,500,
600,700,800) shown in corresponding viewing area (105,110,505,510,605,610,705,710,805,810)；With
During setting, in each described viewing area (105,110,505,510,605,610,705,710,805,810),
Corresponding time window is applied to measurement data (335) by user by means of zoom control (825,830) in special time, described
Zoom control (825,830) can be in each viewing area (105,110,505,510,605,610,705,710,805,810)
In it is mobile along the measurement data (335).
12. method according to any one of claim 9 to 11, it is characterised in that also include：
Unit at least two (135A-N, 200,320,405A-N) are combined in groups, such that it is able to borrow by control module (155)
Help control module (155) and control described group；
Methods described also includes：
By means of the control module (155) link time window, the time window is applied to be displayed in each viewing area
(105,110,505,510,605,610,705,710,805,810) in the unit (135A-N, 200,320,
Measurement data (335) 405A-N), thus user can be by means of zoom control (825,830) by following described each list
The measurement data (335) of first (135A-N, 200,320,405A-N) synchronously moves the time window, described to control
Time window.
13. method according to any one of claim 9 to 12, it is characterised in that also include：
By means of control module (155), in the same time and independently of the absolute time, start unit (135A-N,
The process carried out on material 200,320,405A-N).
A kind of 14. computer program products, the computer program product includes program part, when described program part is carried in
The computer implemented method described in perform claim requirement 10 to 13 is designed to when in computer.
A kind of 15. figures for controlling, detecting, adjust and/or analyzing biology, biochemistry, chemistry and/or physical process are used
Family interface, including：
With special ratios and ad-hoc location at least two viewing areas (105,110,505,510,605,610,705,710,
805,810), wherein, each viewing area (105,110,505,510,605,610,705,710,805,810) and unit
(135A-N, 200,320,405A-N) is associated, and the unit (135A-N, 200,320,405A-N) is designed to receive thing
Matter, to perform at least one biology, biochemistry, chemistry and/or physical process on the material；
Wherein, each in the unit (135A-N, 200,320,405A-N) has at least one sensor, the sensing
Device is configured as the detection measurement data (335) relevant with the process；And
Wherein, in each viewing area (105,110,505,510,605,610,705,710,805,810), described two lists
The measurement data (335) of first (135A-N, 200,320,405A-N) shows with corresponding temporal correlation, the time phase
Closing property allows to obtain information based on the intrinsic relation in shown measurement data (335).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14002995.0 | 2014-08-29 | ||
| EP14002995.0A EP2990900B1 (en) | 2014-08-29 | 2014-08-29 | System and method for control, acquisition, configuration and/or analysis of biological, biochemical, chemical and/or physical processes by using data correlation |
| PCT/EP2015/001316 WO2016029979A1 (en) | 2014-08-29 | 2015-06-30 | System, method, computer program product, and user interface for controlling, detecting, regulating, and/or analyzing biological, biochemical, chemical, and/or physical processes |
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| CN106796431A true CN106796431A (en) | 2017-05-31 |
| CN106796431B CN106796431B (en) | 2022-03-25 |
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| EP (1) | EP2990900B1 (en) |
| CN (1) | CN106796431B (en) |
| WO (1) | WO2016029979A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11985075B1 (en) * | 2013-02-04 | 2024-05-14 | C/Hca, Inc. | Data stream processing for dynamic resource scheduling |
| EP3177258A4 (en) | 2014-08-08 | 2018-09-12 | Fremon Scientific, Inc. | Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance |
| EP3790605A1 (en) | 2018-05-07 | 2021-03-17 | Fremon Scientific, Inc. | Thawing biological substances |
| US10634558B1 (en) | 2018-11-13 | 2020-04-28 | Anna Ailene Scott | Air quality monitoring system and enhanced spectrophotometric chemical sensor |
| US10697947B1 (en) | 2019-01-23 | 2020-06-30 | Project Canary, Inc. | Apparatus and methods for reducing fugitive gas emissions at oil facilities |
| EP3702849B1 (en) * | 2019-02-26 | 2023-07-26 | Sartorius Stedim Data Analytics AB | Optimized process control |
| US20220138341A1 (en) * | 2019-04-12 | 2022-05-05 | Sumitomo Electric Industries, Ltd. | Data visualization apparatus, data processing method, and non-transitory computer-readable storage medium |
| US11150167B1 (en) | 2020-04-03 | 2021-10-19 | Project Canary, Pbc | Air sampling actuator and associated method |
| CA3191655A1 (en) | 2020-09-10 | 2022-03-17 | Anna Ailene Scott | Air quality monitoring system and method |
| DE102020124301A1 (en) | 2020-09-17 | 2022-03-17 | GDS Holding GmbH | Process for extending the shelf life of unfermented foods and microorganisms for use in such a process |
| US11774426B1 (en) | 2022-03-25 | 2023-10-03 | Project Canary, Pbc | Emissions detection system and methods |
| US11861753B1 (en) | 2023-02-01 | 2024-01-02 | Project Canary, Pbc | Air quality monitors minimization system and methods |
| US11727519B1 (en) | 2023-02-01 | 2023-08-15 | Project Canary, Pbc | Air quality monitors minimization system and methods |
| US11887203B1 (en) | 2023-02-01 | 2024-01-30 | Project Canary, Pbc | Air quality monitors minimization system and methods |
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Also Published As
| Publication number | Publication date |
|---|---|
| US11158399B2 (en) | 2021-10-26 |
| EP2990900B1 (en) | 2017-04-12 |
| WO2016029979A1 (en) | 2016-03-03 |
| US20170277829A1 (en) | 2017-09-28 |
| EP2990900A1 (en) | 2016-03-02 |
| CN106796431B (en) | 2022-03-25 |
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