CN106751921A - A kind of silk fabric enhancing composite and preparation method thereof - Google Patents
A kind of silk fabric enhancing composite and preparation method thereof Download PDFInfo
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- CN106751921A CN106751921A CN201611127586.3A CN201611127586A CN106751921A CN 106751921 A CN106751921 A CN 106751921A CN 201611127586 A CN201611127586 A CN 201611127586A CN 106751921 A CN106751921 A CN 106751921A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/16—Applications used for films
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/14—Polymer mixtures characterised by other features containing polymeric additives characterised by shape
- C08L2205/16—Fibres; Fibrils
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Abstract
The present invention relates to a kind of silk fabric enhancing composite and preparation method thereof；Polymer Solution is prepared using formic acid dissolving, is then poured and is cast from boiled silk fabric, produced a kind of silk fabric enhancing composite of excellent performance.Preparation method of the present invention simply, is conveniently operated, is easy to industrialization.Silk fabric enhancing composite prepared by the present invention has good fiber and macromolecule interfacial degrees of fusion, therefore excellent in mechanical performance, additionally, the composite has good transparency.Material therefor of the present invention all has good biocompatibility, the excellent in mechanical performance of gained composite, and material proterties plasticity is high, thus in regenerative medicine field, such as endocranium, esophagus, blood vessel, Wound dressing is with a wide range of applications and application value higher.
Description
Technical field
The invention belongs to technical field of composite materials, and in particular to a kind of silk fabric strengthens composite and its preparation side
Method, prepared material has wide application prospects in regenerative medicine field.
Background technology
China is the major producing country of silk, and silk yield accounts for more than the 70% of world wide production.In recent years, the research of silk
High-technology field, such as photoelectron and biological medicine just are extended to from traditional field of textiles with application, especially as biology
Medical material has been achieved for impressive progress.It, by natural silk degumming, is a kind of natural knot without physiologically active that fibroin albumen is
Structure albumen, mainly by three kinds of simple amino acid：Glycine, alanine and serine composition, they account for Tot Prot
85% or so.Silk after degumming has good biocompatibility and mechanical property, as suture clinically
Using existing many decades.
Silk has wide as a kind of natural protein fibre of excellent in mechanical performance in fibrous composite field
Application prospect, particularly in biomedicine field.However, the multilevel hierarchy that silk is possessed in itself, particularly internal in nanometer
The beta sheet crystalline texture that size is formed so that silk fiber is difficult to mutually be merged with macromolecular material, it is impossible to form compatible
Combination interface, causes silk to strengthen composite materials property poor.Prior art improves silk fiber using lithium bromide pretreatment
With the interface binding power between silk-fibroin matrix, unidirectional enhanced experiment effect is obtained；But the preparation technology is complex, and
Enhancing film is only strengthened along machine direction, is declined on the contrary in vertical fibers directional performance, it is impossible to industrialize.Therefore need to grind
The method for the sending out new composite all excellent to obtain all directions performance.
The content of the invention
Strengthen composite and its preparation it is an object of the invention to provide a kind of silk fabric with excellent mechanical performance
Method, directly realizes strengthening with boiled silk fabric, not only technique simplify, beneficial to mass, while obtaining all directions performance all
Excellent composite, with fabulous application prospect and market value.
To reach above-mentioned purpose, the technical solution adopted by the present invention is that a kind of silk fabric strengthens the preparation of composite
Method, comprises the following steps：Macromolecule formic acid solution is obtained during macromolecule dissolution is entered into formic acid；By the silk fabric of degumming process
It is placed in mould, is then injected into macromolecule formic acid solution, silk weave composite is obtained after dried process；Then silk is knitted
Thing composite is placed in water, organic solvent or cross-linking agent solution and is post-processed, and obtains silk fabric enhancing composite.
In above-mentioned preparation method, the silk is one or more in mulberry silk, tussah silk, ricinus silk.
In above-mentioned preparation method, the silk fabric is woven fabric, knitted fabric or braid；Preferably, the present invention is first
Silk is prepared into silk fabric, then carries out degumming process, respinned the step of knitting, creative holding rather than the degumming of conventional elder generation
The mechanical strength of silk fabric, so as to fabric enhancing effect can be played effectively.
In above-mentioned preparation method, after injection macromolecule formic acid solution, as dried process side by the way of solvent flashing
Formula, the mode preferably volatilized naturally can increase silk fabric and high molecular interface uniformity, improve both interface effects
Should.Especially, macromolecule formic acid solution is poured and cast from boiled silk fabric by the present invention, and silk can occur significantly molten in formic acid
It is swollen and insoluble, it is swelling after silk inside can absorb a large amount of formic acid solvents, macromolecule can with formic acid to silk fiber inside
Infiltration, forms a kind of inner molecular structure feature being interweaved, namely form silk fiber surface during dry
With high molecular perfect interface fusion so that the mechanical property of composite is greatly improved.
In above-mentioned preparation method, the macromolecule is fibroin albumen, shitosan, hyaluronic acid, gelatin, collagen or Buddhist nun
Dragon；The present invention not only has preferable treatment effect to biomass macromolecule, and to non-biological material such as nylon, also has very
Good effect, overcomes the problem of existing fibroin albumen and non-biological material poor compatibility.
In above-mentioned preparation method, the organic solvent is methyl alcohol, ethanol；The crosslinking agent is Geniposide, glutaraldehyde, 1-
(3- dimethylamino-propyls) -3- ethyl-carbodiimide hydrochlorides（EDC）Or N-hydroxy-succinamide (NHS).
In above-mentioned preparation method, the silk fabric of degumming process is 1 with high molecular mass ratio:（1~99）.
In above-mentioned preparation method, the concentration of formic acid is 98wt%；The concentration of macromolecule formic acid solution is 2~8wt%；Crosslinking agent
The concentration of solution is 0.1~10wt%；Formic acid makees the interface that solvent forms stabilization beneficial to macromolecule and silk fabric, by formic acid
The restriction of concentration and polymer concentration, on the one hand promote silk occur it is swelling enough, on the other hand can promote macromolecule to
Silk fiber internal penetration, so as to form the interface interaction power for staggeredly combining, obtains excellent compound mechanics performance.
In above-mentioned preparation method, post processing is that silk weave composite is placed in into water, organic solvent or cross-linking agent solution
Middle immersion 0.5~1 hour, then spontaneously dries.Post processing can promote macromolecular material to form the physical and mechanical properties of stabilization,
Meet requirement of the practical application to stable physical property.
Silk fabric enhancing composite prepared by the present invention, is made up of boiled silk fabric and macromolecule matrix, wherein
The weight content of boiled silk fabric is 1%~50%；The tensile strength of composite is 80MPa~300MPa, elongation at break
It is 5~50%, Young's modulus is 2~5GPa；Composite is transparent material, light transmittance 50~95%.
Therefore composite is strengthened the invention also discloses the silk fabric prepared according to above-mentioned preparation method.
Because above-mentioned technical proposal is used, the present invention has following advantages compared with prior art：
（1）Preparation method disclosed by the invention is simple, controllability strong, be easy to mass, is applicable what existing textile technology was obtained
Different fabric types（Woven, knitting, braiding）, fabric construction, the silk fabric of Density, then by conventional degumming tech
Can be used as obtain compound with Polymer Solution of reinforcement strengthens composite.
（2）The mechanical property of silk fabric enhancing composite prepared by the present invention is very excellent, and the performance is not only
It is unidirectional, is significantly improved in individual direction；The silk fabric enhancing film that especially prepared by the inventive method is transparent
Shape, light transmittance can be in 50~95% regulation and control.
（3）Preparation method controllability of the invention is strong, and the properties of the composite of preparation can be de- by regulation
Adhesive process, silk fabric content, polymer concentration, post-processing technology regulate and control, and the compound of various occasions is applicable so as to prepare
Material, for its industrialization provides good basis.
Specific embodiment
With reference to embodiment, the invention will be further described：
Embodiment one
（1）Woven Light of Mulberry Silk Fabrics boils 30min degummings with 0.5% sodium bicarbonate solution, and degumming silkworm is obtained after being repeated 3 times
Silk fabrics；
（2）98% first will be dissolved in by the Regenerated Bombyx mori Silk Fibroin film obtained after the dissolving of 9.8MLiBr solution, dialysis, drying
In acid, the fibroin albumen formic acid solution of concentration 4% is obtained；
（3）Degummed mulberry silk fabric is placed in mould, fibroin albumen formic acid solution is cast on degummed mulberry silk fabric, from
Light of Mulberry Silk Fabrics fibroin membrane is obtained after right solvent flashing；
（4）Light of Mulberry Silk Fabrics fibroin membrane is placed in 30min is soaked in deionized water, then spontaneously dried；Obtain Light of Mulberry Silk Fabrics
Enhancing fibroin membrane；
The content of silk fabric is 10% in above-mentioned Light of Mulberry Silk Fabrics enhancing fibroin film composite material；The stretching of gained composite
Intensity is 120.6 ± 8.1MPa, elongation at break 26.6 ± 2.1%, the GPa of Young's modulus 3 ± 0.1, light transmittance 80.6%.
Embodiment two
（1）Knitting tussah silk textiles boil 30min degummings with 0.5% sodium carbonate liquor, and degumming tussah silk is obtained after being repeated 3 times
Fabric；
（2）The Regenerated Bombyx mori Silk Fibroin film obtained after 9.8M dissolvings, dialysis, drying is dissolved in 98% formic acid, obtains dense
The fibroin albumen formic acid solution of degree 8%；
（3）Degumming tussah silk textiles are placed in mould, fibroin albumen formic acid solution is cast on degumming tussah silk textiles, from
Tussah silk textiles Bombyx mori Silk Fibroin film is obtained after right solvent flashing；
（4）Tussah silk textiles Bombyx mori Silk Fibroin film is placed in 75% ethanol solution treatment 30min, is then spontaneously dried and is obtained tussah silk
Fabric strengthens Bombyx mori Silk Fibroin film.
The content of silk fabric is 15% in above-mentioned tussah silk textiles enhancing Bombyx mori Silk Fibroin film composite material；Gained composite wood
The tensile strength of material is 180.1 ± 6.1MPa, elongation at break 36.5 ± 1.8%, the GPa of Young's modulus 3.2 ± 0.1, light transmittance
78.6%。
Embodiment three
（1）Woven Light of Mulberry Silk Fabrics boils 30min degummings with 0.05% sodium carbonate liquor, and degummed mulberry silk is obtained after being repeated 3 times
Fabric；
（2）Dissolve the chitosan in 98% formic acid, obtain the shitosan formic acid solution of concentration 2%；
（3）Shitosan formic acid solution is cast on boiled silk fabric, silk fabric shell is obtained after natural solvent flashing and is gathered
Sugared film；
（4）Light of Mulberry Silk Fabrics chitosan film is placed in 1h is processed in 4% sodium hydroxide solution, then after deionized water thoroughly cleaning
Natural drying obtains Light of Mulberry Silk Fabrics enhancing chitosan film.
The content of silk fabric is 20% in above-mentioned composite；The tensile strength of gained composite be 158.6 ±
7.1MPa, elongation at break 36.6 ± 2.1%, the GPa of Young's modulus 3.2 ± 0.1, light transmittance 75.6%.
Example IV
（1）Mulberry silk woven tube boils 30min degummings with 0.05% sodium carbonate liquor, degummed mulberry silk is obtained after being repeated 3 times and is compiled
Knit pipe；
（2）Dissolve the chitosan in 98% formic acid, obtain the shitosan formic acid solution of concentration 2%；
（3）Shitosan formic acid solution is cast in boiled silk woven tube, silk fabric shell is obtained after natural solvent flashing
Glycan conduit；
（4）Light of Mulberry Silk Fabrics chitosan catheter is placed in 1h is processed in 4% sodium hydroxide solution, then deionized water thoroughly cleaning
Spontaneously dry afterwards and obtain silk fabric enhancing chitosan catheter.
The content of silk fabric is 30% in above-mentioned composite；The tensile strength of gained composite be 158.6 ±
7.1MPa, elongation at break 36.6 ± 2.1%, the GPa of Young's modulus 3.2 ± 0.1, light transmittance 75.6%.
Embodiment five
（1）Woven ricinus silk fabric boils 30min degummings with 0.05% sodium carbonate liquor, and degumming silkworm is obtained after being repeated 3 times
Silk fabrics；
（2）Hyaluronic acid is dissolved in 98% formic acid, the hyaluronic acid formic acid solution of concentration 2% is obtained；
（3）Hyaluronic acid formic acid solution is cast on boiled silk fabric, it is saturating to obtain silk fabric after natural solvent flashing
Bright matter sorrel；
（4）Light of Mulberry Silk Fabrics enhancing hyaluronic acid membrane is placed in 5%EDC/2.5%NHS ethanol crosslinking agents and processes 1h, then go from
Spontaneously dried after sub- water thoroughly cleaning and obtain silk fabric enhancing hyaluronic acid membrane.
The content of silk fabric is 50% in above-mentioned composite；The tensile strength of gained composite be 158.6 ±
7.1MPa, elongation at break 36.6 ± 2.1%, the GPa of Young's modulus 3.2 ± 0.1, light transmittance 75.6%.
Embodiment six
（1）Woven Light of Mulberry Silk Fabrics boils 30min degummings with 0.5% sodium bicarbonate solution, and degumming silkworm is obtained after being repeated 3 times
Silk fabrics；
（2）Nylon is dissolved in 98% formic acid, the nylon formic acid solution of concentration 4% is obtained；
（3）Degummed mulberry silk fabric is placed in mould, nylon formic acid solution is cast on degummed mulberry silk fabric, waved naturally
Light of Mulberry Silk Fabrics nylon membrane is obtained after hair solvent；
（4）Light of Mulberry Silk Fabrics nylon membrane is placed in 30min is soaked in deionized water, then spontaneously dried；Obtain Light of Mulberry Silk Fabrics
Enhancing nylon membrane；
The content of silk fabric is 10% in above-mentioned Light of Mulberry Silk Fabrics enhancing nylon composite materials；The stretching of gained composite is strong
It is 120.6 ± 8.1MPa to spend, elongation at break 26.6 ± 2.1%, the GPa of Young's modulus 3 ± 0.1, light transmittance 80.6%.
Above-mentioned percentage is all mass percent, and preparation method disclosed by the invention is simple, controllability strong, be easy to batch
Change, be applicable the different fabric types that existing textile technology is obtained（Woven, knitting, braiding）, fabric construction, the silk of Density
Fabric, then can be used as reinforcement with the compound acquisition enhancing composite of Polymer Solution by conventional degumming tech；It is compound
The tensile strength of material is 80MPa~300MPa, and elongation at break is 5~50%, and Young's modulus is 2~5GPa；Composite is
Transparent material, light transmittance 50~95%；Achieve unexpected technique effect.
Claims (10)
1. a kind of silk fabric strengthens the preparation method of composite, it is characterised in that comprise the following steps：By macromolecule dissolution
Enter and obtain macromolecule formic acid solution in formic acid；The silk fabric of degumming process is placed in mould, macromolecule formic acid is then injected into
Solution, obtains silk weave composite after dried process；Then silk weave composite is placed in water, organic solvent or friendship
Post-processed in connection agent solution, obtained silk fabric enhancing composite.
2. preparation method according to claim 1, it is characterised in that：The silk is mulberry silk, tussah silk, ricinus silk
In one or more.
3. preparation method according to claim 1, it is characterised in that：The silk fabric be woven fabric, knitted fabric or
Braid.
4. preparation method according to claim 1, it is characterised in that：Silk is first prepared into silk fabric, then is taken off
Glue treatment, obtains the silk fabric of degumming process.
5. preparation method according to claim 1, it is characterised in that：The organic solvent is methyl alcohol or ethanol；It is described
Crosslinking agent is Geniposide, glutaraldehyde, 1- (3- dimethylamino-propyls) -3- ethyl-carbodiimide hydrochlorides or N- hydroxysuccinimidyl acyls
Imines.
6. preparation method according to claim 1, it is characterised in that：The silk fabric of degumming process and high molecular quality
Than being 1:（1~99）；The concentration of macromolecule formic acid solution is 2~8wt%；The concentration of cross-linking agent solution is 0.1~10wt%.
7. preparation method according to claim 1, it is characterised in that：The macromolecule is fibroin albumen, shitosan, transparent
One or more of matter acid, gelatin, nylon.
8. preparation method according to claim 1, it is characterised in that：The post processing is to put silk weave composite
Soaked 0.5~1 hour in Yu Shui, organic solvent or cross-linking agent solution, then spontaneously dried.
9. the silk fabric enhancing composite that prepared by any one preparation method according to claim 1-8.
10. application of the silk fabric enhancing composite in biomaterial for medical purpose is prepared described in claim 9.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721348A (en) * | 2019-10-24 | 2020-01-24 | 湖南师范大学 | Natural silk reinforced hydroxyapatite/chitosan composite membrane and preparation method thereof |
| CN110818923A (en) * | 2019-11-15 | 2020-02-21 | 北京航空航天大学 | Preparation method of natural mulberry/tussah silk fabric reinforced epoxy resin composite material |
| CN113696562A (en) * | 2021-08-23 | 2021-11-26 | 西南大学 | High-strength transparent silkworm cocoon composite material and preparation method and application thereof |
| CN114099794A (en) * | 2021-11-18 | 2022-03-01 | 北京航空航天大学 | Bioabsorbable orthopedic implant material and preparation method thereof |
| CN116350848A (en) * | 2023-03-31 | 2023-06-30 | 鹏拓生物科技(杭州)有限公司 | Silk protein film, preparation and use methods and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266992A1 (en) * | 2001-09-11 | 2004-12-30 | Claudio Migliaresi | Method for the preparation of silk fibron hydrogels |
| CN104888279A (en) * | 2015-03-16 | 2015-09-09 | 绍兴振德医用敷料有限公司 | Collagen/silk fibroin composite support and manufacturing method and application thereof |
| CN105056305A (en) * | 2015-09-02 | 2015-11-18 | 无锡市第三人民医院 | Dermal substitute and preparation method thereof |
| CN105521522A (en) * | 2015-11-11 | 2016-04-27 | 陕西玉航电子有限公司 | Preparation method of silk fibroin and chitosan three-dimensional scaffold material |
-
2016
- 2016-12-09 CN CN201611127586.3A patent/CN106751921A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266992A1 (en) * | 2001-09-11 | 2004-12-30 | Claudio Migliaresi | Method for the preparation of silk fibron hydrogels |
| CN104888279A (en) * | 2015-03-16 | 2015-09-09 | 绍兴振德医用敷料有限公司 | Collagen/silk fibroin composite support and manufacturing method and application thereof |
| CN105056305A (en) * | 2015-09-02 | 2015-11-18 | 无锡市第三人民医院 | Dermal substitute and preparation method thereof |
| CN105521522A (en) * | 2015-11-11 | 2016-04-27 | 陕西玉航电子有限公司 | Preparation method of silk fibroin and chitosan three-dimensional scaffold material |
Non-Patent Citations (1)
| Title |
|---|
| KWEON ET AL: "physical properties of silk fibroin/chitosan blend films", 《JOURNAL OF APPLIED POLYMER SCIENCE》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721348A (en) * | 2019-10-24 | 2020-01-24 | 湖南师范大学 | Natural silk reinforced hydroxyapatite/chitosan composite membrane and preparation method thereof |
| CN110721348B (en) * | 2019-10-24 | 2021-10-01 | 湖南师范大学 | Natural silk reinforced hydroxyapatite/chitosan composite membrane and preparation method thereof |
| CN110818923A (en) * | 2019-11-15 | 2020-02-21 | 北京航空航天大学 | Preparation method of natural mulberry/tussah silk fabric reinforced epoxy resin composite material |
| CN113696562A (en) * | 2021-08-23 | 2021-11-26 | 西南大学 | High-strength transparent silkworm cocoon composite material and preparation method and application thereof |
| CN113696562B (en) * | 2021-08-23 | 2022-05-24 | 西南大学 | High-strength transparent silkworm cocoon composite material and preparation method and application thereof |
| CN114099794A (en) * | 2021-11-18 | 2022-03-01 | 北京航空航天大学 | Bioabsorbable orthopedic implant material and preparation method thereof |
| CN116350848A (en) * | 2023-03-31 | 2023-06-30 | 鹏拓生物科技(杭州)有限公司 | Silk protein film, preparation and use methods and application |
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Application publication date: 20170531 |