CN106747400A - A kind of high-performance bioceramic material - Google Patents
A kind of high-performance bioceramic material Download PDFInfo
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- CN106747400A CN106747400A CN201611029218.5A CN201611029218A CN106747400A CN 106747400 A CN106747400 A CN 106747400A CN 201611029218 A CN201611029218 A CN 201611029218A CN 106747400 A CN106747400 A CN 106747400A
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- 239000003462 bioceramic Substances 0.000 title claims abstract description 37
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims abstract description 38
- 239000008367 deionised water Substances 0.000 claims abstract description 26
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000002270 dispersing agent Substances 0.000 claims abstract description 25
- 239000004254 Ammonium phosphate Substances 0.000 claims abstract description 19
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 19
- 229910052581 Si3N4 Inorganic materials 0.000 claims abstract description 19
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims abstract description 19
- 235000019289 ammonium phosphates Nutrition 0.000 claims abstract description 19
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 19
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 19
- 239000001110 calcium chloride Substances 0.000 claims abstract description 19
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 19
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000019353 potassium silicate Nutrition 0.000 claims abstract description 19
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims abstract description 19
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- YHWCPXVTRSHPNY-UHFFFAOYSA-N butan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-] YHWCPXVTRSHPNY-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002002 slurry Substances 0.000 claims description 36
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 239000007789 gas Substances 0.000 claims description 14
- 238000002390 rotary evaporation Methods 0.000 claims description 13
- 238000005273 aeration Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 125000004122 cyclic group Chemical group 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 150000001336 alkenes Chemical class 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 6
- 239000012620 biological material Substances 0.000 abstract description 5
- 239000000919 ceramic Substances 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000004068 calcium phosphate ceramic Substances 0.000 description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a kind of high-performance bioceramic material, its formula is as follows：30 50 parts of ammonium phosphate, 25 35 parts of calcium chloride, 8 14 parts of nano-calcium carbonate, 4 10 parts of silicon nitride, 10 16 parts of waterglass, 10 15 parts of aluminium chloride, 11 15 parts of tetrabutyl titanate, 34 parts of dispersant, 20 40 parts of deionized water, and there is provided preparation method.Preferably, bioactivity is higher for ceramic biocompatibility of the invention, with certain anti-inflammatory bactericidal property, meanwhile, possess good mechanical performance, biomaterial can be substituted as bone repair.
Description
Technical field
The invention belongs to bone repair technical field, and in particular to a kind of high-performance bioceramic material.
Background technology
With the development of material science and technology, the particularity that biomaterial is repaired to body tissue, substituted and regenerated by it
Can, have become one of important research direction of current biomedical sector.Biological hard tissue substitute material is earliest to use body
Bone, Animal Bone, are developed into using stainless steel and plastics later, and because stainless steel has dissolved, corrosion and fatigue problem, plastics are deposited
In stability difference and the problem of low intensity.The bottleneck of biomaterial development is thus resulted in, the appearance of bioceramic is improved existing
The deficiency of alternative materials, because of its many advantages, therefore, bioceramic is provided with vast potential for future development.
Calcium phosphate ceramic (CPC) is the important species in biological active ceramic material, studies at present and is using most
Hydroxyapatite (HA) and tricalcium phosphate (TCP).Calcium phosphate ceramic contains CaO and P2O5Two kinds of compositions, are to constitute human body hard tissue
Important inorganic substances, implantation human body after, its surface with tissue can by the combination of key, reach completely it is affine.HA is biological
Active ceramic is typical bioactive ceramics, can form chemical key and be combined with being organized on interface after implanting, with compared with
Mechanical property high, resolvability is relatively low in human physiological environment.
The content of the invention
It is an object of the invention to provide a kind of high-performance bioceramic material, ceramic biocompatibility of the invention is preferable,
Bioactivity is higher, with certain anti-inflammatory bactericidal property, meanwhile, possessing good mechanical performance, can be replaced as bone repair
For biomaterial.
A kind of high-performance bioceramic material, its formula is as follows：
Ammonium phosphate 30-50 parts, calcium chloride 25-35 parts, nano-calcium carbonate 8-14 parts, silicon nitride 4-10 parts, waterglass 10-16 parts,
Aluminium chloride 10-15 parts, tetrabutyl titanate 11-15 parts, dispersant 3-4 parts, deionized water 20-40 parts.
The dispersant uses polyvinylpyrrolidone.
Preferably, each group is divided into ammonium phosphate 35-45 parts, calcium chloride 28-33 parts, nano-calcium carbonate 9-11 parts, silicon nitride
6-8 parts, waterglass 13-15 parts, aluminium chloride 11-14 parts, tetrabutyl titanate 13-14 parts, dispersant 3-4 parts, deionized water 30-35
Part.
Preferably, each group is divided into 38 parts of ammonium phosphate, 31 parts of calcium chloride, 10 parts of nano-calcium carbonate, 7 parts of silicon nitride, water glass
14 parts of glass, 13 parts of aluminium chloride, 14 parts of tetrabutyl titanate, 4 parts of dispersant, 33 parts of deionized water.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 3-5h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 2-4h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 300-1000r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 15-30mL/
Min, the aerated reaction reacts for cyclic aeration, and the pressure of the aerated reaction is 0.5-1.2MPa, and the reaction temperature is
Room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 80-100 DEG C, and the pressure of the revolving evaporation is 0.2-
0.5MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 60-70 DEG C, institute
The pressure for stating pressurized high-temperature reaction is 10-20MPa, and the temperature is 800-1000 DEG C.
Compared with prior art, the invention has the advantages that：
1st, preferably, bioactivity is higher for ceramic biocompatibility of the invention, with certain anti-inflammatory bactericidal property, meanwhile, tool
Standby good mechanical performance, can substitute biomaterial as bone repair.
2nd, the present invention is using suspension and slurries as precursor liquid, is aerated, secondary aerated reaction, is possible to phosphoric acid
DFP, carborundum, titanium source material tight are combined, with good combination effect, while biological living through the material after high temperature sintering
Property is steadily improved, and mechanical strength is further improved.
3rd, the present invention to environment without particular/special requirement；Material purity is high, and strong mechanical property, it is easy to carry out industrial metaplasia
Produce.
Specific embodiment
The present invention is described further with reference to embodiment：
Embodiment 1
A kind of high-performance bioceramic material, its formula is as follows：
30 parts of ammonium phosphate, 25 parts of calcium chloride, 8 parts of nano-calcium carbonate, 4 parts of silicon nitride, 10 parts of waterglass, 10 parts of aluminium chloride, metatitanic acid
11 parts of N-butyl, 3 parts of dispersant, 20 parts of deionized water.
The dispersant uses polyvinylpyrrolidone.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 3h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 2h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 300r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 15mL/min, institute
Aerated reaction is stated for cyclic aeration reacts, the pressure of the aerated reaction is 0.5MPa, and the reaction temperature is room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 80 DEG C, and the pressure of the revolving evaporation is 0.2MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 60 DEG C, described to add
The pressure of super pressure-high temperature reaction is 10MPa, and the temperature is 800 DEG C.
Embodiment 2
A kind of high-performance bioceramic material, its formula is as follows：
50 parts of ammonium phosphate, 35 parts of calcium chloride, 14 parts of nano-calcium carbonate, 10 parts of silicon nitride, 16 parts of waterglass, 15 parts of aluminium chloride, titanium
15 parts of sour N-butyl, 4 parts of dispersant, 40 parts of deionized water.
The dispersant uses polyvinylpyrrolidone.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 5h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 4h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 1000r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 30mL/min, institute
Aerated reaction is stated for cyclic aeration reacts, the pressure of the aerated reaction is 1.2MPa, and the reaction temperature is room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 100 DEG C, and the pressure of the revolving evaporation is 0.5MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 70 DEG C, described to add
The pressure of super pressure-high temperature reaction is 10-20MPa, and the temperature is 1000 DEG C.
Embodiment 3
A kind of high-performance bioceramic material, its formula is as follows：
35 parts of ammonium phosphate, 28 parts of calcium chloride, 9 parts of nano-calcium carbonate, 6 parts of silicon nitride, 13 parts of waterglass, 11 parts of aluminium chloride, metatitanic acid
13 parts of N-butyl, 3 parts of dispersant, 30 parts of deionized water.
The dispersant uses polyvinylpyrrolidone.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 4h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 3h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 500r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 18mL/min, institute
Aerated reaction is stated for cyclic aeration reacts, the pressure of the aerated reaction is 0.7MPa, and the reaction temperature is room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 90 DEG C, and the pressure of the revolving evaporation is 0.3MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 65 DEG C, described to add
The pressure of super pressure-high temperature reaction is 13MPa, and the temperature is 900 DEG C.
Embodiment 4
A kind of high-performance bioceramic material, its formula is as follows：
45 parts of ammonium phosphate, 33 parts of calcium chloride, 11 parts of nano-calcium carbonate, 8 parts of silicon nitride, 15 parts of waterglass, 14 parts of aluminium chloride, metatitanic acid
14 parts of N-butyl, 4 parts of dispersant, 35 parts of deionized water.
The dispersant uses polyvinylpyrrolidone.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 4h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 3h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 700r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 20mL/min, institute
Aerated reaction is stated for cyclic aeration reacts, the pressure of the aerated reaction is 0.7MPa, and the reaction temperature is room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 85 DEG C, and the pressure of the revolving evaporation is 0.4MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 65 DEG C, described to add
The pressure of super pressure-high temperature reaction is 15MPa, and the temperature is 850 DEG C.
Embodiment 5
A kind of high-performance bioceramic material, its formula is as follows：
38 parts of ammonium phosphate, 31 parts of calcium chloride, 10 parts of nano-calcium carbonate, 7 parts of silicon nitride, 14 parts of waterglass, 13 parts of aluminium chloride, metatitanic acid
14 parts of N-butyl, 4 parts of dispersant, 33 parts of deionized water.
The preparation method of the bioceramic material, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 3h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 3h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
Mixing speed in the preparation method is 800r/min.
Aerated reaction in the step 4 uses ammonia gas, and the gas flow rate of the aerated reaction is 25mL/min, institute
Aerated reaction is stated for cyclic aeration reacts, the pressure of the aerated reaction is 1.0 MPa, and the reaction temperature is room temperature.
The temperature of the rotary evaporation reaction in the step 5 is 95 DEG C, and the pressure of the revolving evaporation is 0.4MPa
The gas of the secondary aerated reaction in the step 6 is nitrogen, and the temperature of the secondary aerated reaction is 65 DEG C, described to add
The pressure of super pressure-high temperature reaction is 18MPa, and the temperature is 850 DEG C.
The bioceramic material of embodiment 1-5 is tested
| Embodiment | Hardness（HV） | Compressive strength MPa | Bending strength MPa | Toughness MPam0.5 |
| Embodiment 1 | 840 | 1100 | 420 | 16 |
| Embodiment 2 | 870 | 1300 | 430 | 15 |
| Embodiment 3 | 850 | 1429 | 437 | 14 |
| Embodiment 4 | 867 | 1234 | 459 | 15 |
| Embodiment 5 | 890 | 1500 | 480 | 16 |
One embodiment of the invention is the foregoing is only, the side of the present invention, all use equivalents or equivalent transformation is not intended to limit
The technical scheme that formula is obtained, all falls within protection scope of the present invention.
Claims (9)
1. a kind of high-performance bioceramic material, it is characterised in that its formula is as follows：
Ammonium phosphate 30-50 parts, calcium chloride 25-35 parts, nano-calcium carbonate 8-14 parts, silicon nitride 4-10 parts, waterglass 10-16 parts,
Aluminium chloride 10-15 parts, tetrabutyl titanate 11-15 parts, dispersant 3-4 parts, deionized water 20-40 parts.
2. a kind of high-performance bioceramic material according to claim 1, it is characterised in that the dispersant uses poly- second
Alkene pyrrolidone.
3. a kind of high-performance bioceramic material according to claim 1, it is characterised in that each group is divided into ammonium phosphate 35-
45 parts, calcium chloride 28-33 parts, nano-calcium carbonate 9-11 parts, silicon nitride 6-8 parts, waterglass 13-15 parts, aluminium chloride 11-14 parts,
Tetrabutyl titanate 13-14 parts, dispersant 3-4 parts, deionized water 30-35 parts.
4. a kind of high-performance bioceramic material according to claim 3, it is characterised in that each group is divided into ammonium phosphate 38
Part, 31 parts of calcium chloride, 10 parts of nano-calcium carbonate, 7 parts of silicon nitride, 14 parts of waterglass, 13 parts of aluminium chloride, 14 parts of tetrabutyl titanate,
4 parts of dispersant, 33 parts of deionized water.
5. a kind of high-performance bioceramic material according to claim 1, it is characterised in that the bioceramic material
Preparation method, its step is as follows：
Step 1, ammonium phosphate and calcium chloride are added into deionized water, are stirred, and form suspension；
Step 2, nano-calcium carbonate, silicon nitride, waterglass, aluminium chloride are sequentially added into deionized water, are stirred, and are formed
Mixed serum,
Step 3, dispersant is added into slurries simultaneously with tetrabutyl titanate and is stirred, and forms forerunner's slurries；
Forerunner's slurries are carried out aerated reaction 3-5h by step 4；
Step 5, after aerated reaction terminates, be put into revolving instrument in carry out rotary evaporation formed thick slurry；
Step 6, secondary aerated reaction 2-4h is carried out by thick slurry, and then cold moudling carry out pressurized high-temperature reaction；
Step 7, after reaction terminates, natural cooling, you can obtain bioceramic material.
6. a kind of high-performance bioceramic material according to claim 5, it is characterised in that stirring in the preparation method
Speed is mixed for 300-1000r/min.
7. a kind of high-performance bioceramic material according to claim 5, it is characterised in that the aeration in the step 4
Reaction uses ammonia gas, and the gas flow rate of the aerated reaction is 15-30mL/min, and the aerated reaction is that cyclic aeration is anti-
Should, the pressure of the aerated reaction is 0.5-1.2MPa, and the reaction temperature is room temperature.
8. a kind of high-performance bioceramic material according to claim 5, it is characterised in that the rotation in the step 5
The temperature for evaporating reaction is 80-100 DEG C, and the pressure of the revolving evaporation is 0.2-0.5MPa.
9. a kind of high-performance bioceramic material according to claim 5, it is characterised in that secondary in the step 6
The gas of aerated reaction is nitrogen, and the temperature of the secondary aerated reaction is 60-70 DEG C, and the pressure of the pressurized high-temperature reaction is
10-20MPa, the temperature is 800-1000 DEG C.
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|---|---|---|---|---|
| CN101156964A (en) * | 2007-11-08 | 2008-04-09 | 浙江大学 | Similar bone biology medical material for slow releasing bioactivity factor as well as its preparing method |
| CN101880033A (en) * | 2010-03-04 | 2010-11-10 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing calcium phosphate for biological ceramics |
| CN104446432A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Magnetic hydroxyapatite bioceramic and preparation method thereof |
| CN104744028A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Tricalcium phosphate/silicon carbide composite biological ceramic and preparation method thereof |
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2016
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156964A (en) * | 2007-11-08 | 2008-04-09 | 浙江大学 | Similar bone biology medical material for slow releasing bioactivity factor as well as its preparing method |
| CN101880033A (en) * | 2010-03-04 | 2010-11-10 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing calcium phosphate for biological ceramics |
| CN104446432A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Magnetic hydroxyapatite bioceramic and preparation method thereof |
| CN104744028A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Tricalcium phosphate/silicon carbide composite biological ceramic and preparation method thereof |
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