CN106730407A - A kind of scanning illuminating method for particle therapy, device and treatment head - Google Patents
A kind of scanning illuminating method for particle therapy, device and treatment head Download PDFInfo
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- CN106730407A CN106730407A CN201611031383.4A CN201611031383A CN106730407A CN 106730407 A CN106730407 A CN 106730407A CN 201611031383 A CN201611031383 A CN 201611031383A CN 106730407 A CN106730407 A CN 106730407A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1065—Beam adjustment
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Abstract
The present invention provides a kind of scan method for particle therapy, device and treatment head.The method according to the invention, including：A obtains the point of irradiation distributed intelligence of the object to be illuminated；B is based on the point of irradiation distributed intelligence to determine Current Scan path；C is scanned according to the Current Scan path；D performs optimization operation when predetermined end condition is not met based on the Current Scan path, to obtain optimization scanning pattern, and the optimization scanning pattern is repeated into step c, d as Current Scan path.The invention has the advantages that：Taken multiple scan using different scanning patterns by same irradiation layer, the unbalanced problem of dosage can effectively be eliminated, and by the optimization to scanning pattern, shorten path length, the time required to reducing treatment, the demand to device power supply (DPS) is reduced, and, path after optimization reduces the requirement to magnet wide-angle deflection, improves whole service efficiency.
Description
Technical field
The present invention relates to radiation cure technical field, more particularly to a kind of scanning illuminating method for particle therapy,
Device and treatment head.
Background technology
Particle radiotherapy is one of current anti-cancer therapies state-of-the-art in the world.(X-ray is put with common photon radiotherapy
Treat) to compare, particle is irradiated to when in patient body, will form maximum dose peak value in particle range terminal, i.e. formed so-called
Bragg peak (Bragg Peak).Thus by accurate control particle beam energy and particle beam irradiation position, can be by agent high
Amount particle cover in target tumor target area, while by the unfavorable of the normal structure around target tumor and normal organ
Exposure dose is reduced at least, so as to realize the dosage distribution more conformal than X-ray radiotherapy, improves the therapeutic effect of tumour,
Reduce side effect.
The usual beam spot size of particle beam that particle accelerator is produced is less than 10 millimeters, thus when needing that the particle beams is equal
When being irradiated to such as a diameter of 10 centimetres of tumor target evenly, then need to utilize particle-irradiation device, beam spot diameter, is only had not
10 cm ranges are expanded to 1 centimetre of the particle beams, while needing to irradiate the particle beam of different-energy, script are only counted
The spread out Bragg peak of mm wide to tumor target along the suitable width of the thickness of direction of illumination, so as in three-dimensional tumor target
Form the dosage distribution of uniform three-dimensional conformal.
Realizing the dosage distribution of above-mentioned three-dimensional conformal generally has two kinds of illuminating methods, respectively two dimension illuminating method and three-dimensional
Illuminating method.Wherein, two-dimentional illuminating method is also referred to as scattering object method.Current 3-D scanning radiation modality is illustrated in Fig. 1.
Its principal mode is, using two orthogonal pole electromagnet of a pair of yawing moments, to make what is come from particle accelerator conveying
The planned track scanning of the particle beams, forms fixed track and (presses treatment in the such as track such as circular or ZigZag shapes, or formation
The track that plan is given).
When all points of irradiation are distributed all Relatively centralizeds, it is clear that requirement to path just than relatively low, conventionally
Each point can be traversed, path that both need not be complicated can also complete (reference picture 2) in the short time.But prior art
Problem is that in many cases, the distribution of tumour is often not necessarily very intensive, and possible its shape is non-interconnected, middle possible
Substantial amounts of hole is had, the important organ of distribution is wherein likely to certainly.
Also, it is referred to as under three-dimensional continuous short scan pattern (fast raster continuos scanning) a kind of,
It is not turned off when line is moved between scanning element, thus dosage can be also contributed on scanning pattern.Generally, this part
Mobile middle dosage (transient dose) is difficult to be taken in treatment plan, and can be by improvement irradiation controlling party
Method also calculates in the dosage of adjacent point of irradiation mobile middle dosage contribution, as long as the spacing of scanning element is fully small, this method
The dose error for bringing can be just controlled enough to small.But, some scanning element gap ratio scanning beam diameters are much larger, using this
Kind control mode is not ideal enough to eliminate the error effects that mobile middle dosage contribution brings.This error, if always using same
One path is scanned, then the accumulation of error that dosage can be caused to be distributed, and especially on the slower direction of sweep speed, causes its agent
The inhomogeneities for measuring distribution is more obvious.
The content of the invention
It is an object of the invention to provide a kind of scanning illuminating method for particle therapy, device and equipment.
According to an aspect of the present invention, there is provided a kind of scanning illuminating method for particle therapy, wherein, for every layer
Object to be illuminated, the described method comprises the following steps：
A obtains the point of irradiation distributed intelligence of the object to be illuminated；
B is based on the point of irradiation distributed intelligence to determine Current Scan path；
C is scanned irradiation according to the Current Scan path；
D performs optimization operation when predetermined end condition is not met based on the Current Scan path, is swept with obtaining optimization
Path is retouched, and the optimization scanning pattern is repeated into step c, d as Current Scan path.
According to an aspect of the present invention, there is provided a kind of scanning means for particle therapy, wherein, wait to shine for every layer
Object is penetrated, the scanning means includes：
Acquisition device, the point of irradiation distributed intelligence for obtaining the object to be illuminated；
Determining device, for determining Current Scan path based on the point of irradiation distributed intelligence；
Performs device, for being scanned according to the Current Scan path；
Optimization device, for when predetermined end condition is not met, optimization operation being performed based on the Current Scan path,
To obtain optimization scanning pattern, and the optimization scanning pattern is repeated into the performs device as Current Scan path
With the operation of optimization device.
Compared with prior art, the present invention has advantages below：Different scanning patterns is used by same irradiation layer
Take multiple scan, dosage unbalanced problem when can effectively eliminate scanning irradiation, and by the excellent of scanning pattern
Change, shorten path length, and then reduce treatment required time, after reducing the demand to device power supply (DPS), also, optimization
Path reduces the requirement to magnet wide-angle deflection, improves whole service efficiency.
Brief description of the drawings
By the detailed description made to non-limiting example made with reference to the following drawings of reading, it is of the invention other
Feature, objects and advantages will become more apparent upon：
Fig. 1 is illustrated in the prior art using the line schematic diagram under dimensional scan patterns；
Fig. 2 is a kind of schematic diagram of scanning pattern used in the prior art；
Fig. 3 is according to one embodiment of the present of invention, using the relative Fig. 1 that can be obtained after prioritization scheme of the invention
Optimization scanning pattern schematic diagram；
Fig. 4 is a kind of scanning pattern schematic diagram of the use prior art according to a preferred embodiment of the invention；
Fig. 5 a to Fig. 5 e are according to one embodiment of the present of invention, after proceeding by optimization from scanning pattern shown in Fig. 4
The schematic diagram of the different preferred path of each bar for obtaining；
Fig. 6 illustrates a kind of schematic flow sheet of scan method of the invention；
Fig. 7 illustrates a kind of apparatus structure schematic diagram of scanning means of the invention.
Same or analogous reference represents same or analogous part in accompanying drawing.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
Reference picture 6, Fig. 6 illustrates a kind of flow of scanning illuminating method for particle therapy of the invention
Figure.
Wherein, methods described includes a kind of energy by computer equipment described in the scanning means that is contained in computer equipment
Enough to carry out the electronic equipment of numerical computations and/or information processing automatically according to the instruction being previously set or store, its hardware includes
But it is not limited to microprocessor, application specific integrated circuit (ASIC), programmable gate array (FPGA), digital processing unit (DSP), embedded
Equipment etc..
Preferably, scanning means of the invention, is contained in scanning treatment head.
Wherein, (reference picture 7) scanning treatment head of the invention includes：The the first scanning magnetic for setting gradually from top to bottom
Iron, the first vacuum box, the second sweeping magnet, the second vacuum box, vacuum window and beam monitoring module, and scanning power supply and power supply
Controller and irradiation control device.
It is highly preferred that the scanning means is contained in the irradiation control device of the scanning treatment head.
Wherein, scanning treatment head of the invention is to each object to be illuminated, and such as tumor tissues are divided into multiple photographs
Layer is penetrated to be irradiated respectively.
Preferably, scanning treatment head is based on scanning means, and method as described in the present invention is used to each irradiation layer, passes through
Step S1 is irradiated to step S5.
With continued reference to Fig. 6, in step sl, scanning means obtains the point of irradiation distributed intelligence of the object to be illuminated.
Wherein, the point of irradiation is used to indicate to need illuminated part, for example, position of tumour cell etc..
Then, in step s 2, scanning means is based on the point of irradiation distributed intelligence to determine Current Scan path.
Wherein, the Current Scan path is traveled through based on pre-defined algorithm to each point of irradiation.When using different
Pre-defined algorithm when, different Current Scan paths can be obtained.For example, circular, zigzag shapes etc..
Then, in step s3, scanning means is scanned according to the Current Scan path.
Specifically, scanning means is by the control to parts such as the first sweeping magnet in treatment head, the second sweeping magnets,
To control particle beam to be scanned along Current Scan path.
Then, in step s 4, when predetermined end condition is not met, scanning means is held based on the Current Scan path
Row optimization operation, to obtain optimization scanning pattern, and repeats step using the optimization scanning pattern as Current Scan path
Rapid S3 to step S4.
Wherein, predetermined end condition includes but is not limited to following at least any one：
1) predetermined scanning times are reached.
2) the realization convergence of the continuous optimization scanning pattern for obtaining several times.Wherein, those skilled in the art should be according to reality
Border situation and demand determine convergent criterion, and here is omitted.
Specifically, scanning means is according to scanning relevant information, such as scanning times, scanning pattern, and whether judgement current
Meet predetermined end condition, when predetermined end condition is not met, continue executing with step S3 to step S4, until meeting predetermined whole
Only condition.
Preferably, scanning means is based on the Current Scan path, using path optimization's algorithm, according to predetermined N number of base
In the scanning pattern optimum results that different random number is obtained, the multiple scanning that scanning irradiation process is divided into corresponding number is irradiated
Journey, implements n times multiple scanning and irradiates according to above-mentioned predetermined optimization scanning pattern respectively.
Wherein, path optimization's algorithm includes but is not limited to following any one algorithm：
1) simulated annealing；Simulated annealing (Simulated Annealing, SA) is based on Monte-Carlo
A kind of random optimizing algorithm of iterative strategy, its starting point is annealing process based on solid matter in physics and general group
Close the similitude between optimization problem.Simulated annealing from a certain initial temperature higher, with the continuous decline of temperature parameter,
Join probability kick characteristic random globally optimal solution for finding object function in solution space, i.e., can be probability in locally optimal solution
Jump out and finally tend to global optimum.
2) genetic algorithm etc..
For example, for the scanning pattern shown in Fig. 2, after being optimized using simulated annealing, can obtain such as Fig. 3 institutes
The optimization scanning pattern for showing.
Compare Fig. 2 and Fig. 3 to understand, it is clear that Fig. 3 is not only compacter on path planning, and can as far as possible avoid weight
The organ wanted.Assuming that slice matrix sizes are arranged for 100 rows 100, then need the point of irradiation to reach 10,000, after optimization
Path is shorter, it is thus possible to save treatment time, also, path after optimization reduces requirement to magnet wide-angle deflection,
Improve whole service efficiency.
First example of the invention, reference picture 4 and Fig. 5 a to Fig. 5 e, wherein path length is shown in Fig. 4
The path length of 425.49mm, Fig. 5 a to Fig. 5 e is respectively 320.639mm, 315.236mm, 327.018mm, 318.478mm with
And 322.611mm.Default scanning times are 5 times, for irradiation layer to be scanned, determine that it is worked as by step S1 and step S2
Preceding scanning pattern is as shown in Figure 4.Also, scanning means controls treatment head in step s3 using the scanning pattern shown in Fig. 4,
So that particle beam is scanned along the path.Then, scanning means judges that Current Scan number of times is 1, does not meet termination bar
Part, then optimize to the current scanning pattern, and obtains new Current Scan path as shown in Figure 5 a.Then, continue executing with
Step S3, control particle beam is scanned along path as shown in Figure 5 a；Then, step S4, scanning means are continued executing with
Judge that Current Scan number of times is 2, do not meet end condition, then based on path shown in Fig. 5 a, carried out using simulated annealing excellent
Obtain scanning pattern as shown in Figure 5 b after change, and continue executing with step S3 being scanned, so repeat, until in step S4
Middle acquisition optimization scanning pattern as depicted in fig. 5e, and continue executing with step S3 and be scanned being based on the path, then, in step
In rapid S4, judge that Current Scan number of times is 5 times, meet predetermined end condition, then do not continue to perform.
Preferably, the method according to the invention, every time perform step S3 when institutes according to the incomplete phase in Current Scan path
Together.
With continued reference to foregoing First example, compare by taking Fig. 5 b and Fig. 5 c as an example, it can be seen that twice sweep path is simultaneously
It is incomplete same.Especially in the Y direction, scanning pattern twice has larger difference.Because scanning power supply is swept in the Y direction
The speed retouched is slower, thus Multiple-Scan will more effectively eliminate the inhomogeneities of dosage in Y-direction.Reduce to scanning power supply
Parameter request.
The method according to the invention, is taken multiple scan by same irradiation layer using different scanning patterns, can
Dosage unbalanced problem when effectively eliminating scanning irradiation, and by the optimization to scanning pattern, path length is shortened,
And then the time required to reducing treatment, reduce the demand to device power supply (DPS), also, path after optimization reduce it is big to magnet
The requirement of angular deflection, improves whole service efficiency.
Reference picture 7.Fig. 7 illustrates the one of the invention structural representation for the scanning means of particle therapy
Figure.
Scanning means of the invention includes acquisition device 101, determining device 102, performs device 103 and optimization device
104.Wherein, scanning means and its operation performed by each device for being included and each step described in foregoing reference picture 6
Rapid process is similar, and here is omitted.
Wherein, heterogeneous entities of the invention can be realized by computer equipment, it is preferable that side of the invention
Case is realized by being contained in providing the mean in computer equipment.Computer equipment include one kind can according to being previously set or
The instruction of storage, carries out the electronic equipment of numerical computations and/or information processing automatically, and its hardware includes but is not limited to microprocessor
Device, application specific integrated circuit (ASIC), programmable gate array (FPGA), digital processing unit (DSP), embedded device etc..Computer
Equipment includes the network equipment and/or user equipment.Wherein, the network equipment includes but is not limited to single network server, multiple nets
Network server group into server group or based on cloud computing (Cloud Computing) by a large amount of main frames or webserver structure
Into cloud, wherein, cloud computing is one kind of Distributed Calculation, a super void being made up of the computer collection of a group loose couplings
Intend computer.User equipment includes but is not limited to any one can pass through keyboard, mouse, remote control, touch pad or sound with user
The modes such as control equipment carry out the electronic product of man-machine interaction, for example, personal computer, panel computer, smart mobile phone, PDA, game
Machine or IPTV etc..Wherein, user equipment and the network residing for the network equipment include but is not limited to internet, wide area network, metropolitan area
Net, LAN, VPN etc..
It should be noted that user equipment, the network equipment and network are only for example, other are existing or may go out from now on
Existing user equipment, the network equipment and network are such as applicable to the present invention, should also be included within the scope of the present invention, and
It is incorporated herein by reference.
Software program of the invention can be by computing device realizing above step or function.Similarly, the present invention
Software program (including related data structure) can be stored in computer readable recording medium storing program for performing, for example, RAM is stored
Device, magnetically or optically driver or floppy disc and similar devices.In addition, some steps of the invention or function can employ hardware to reality
It is existing, for example, coordinating so as to perform the circuit of each function or step as with processor.
In addition, a part of the invention can be applied to computer program product, such as computer program instructions, when its quilt
When computer is performed, by the operation of the computer, the method according to the invention and/or technical scheme can be called or provided.
And the programmed instruction of the method for the present invention is called, it is possibly stored in fixed or moveable recording medium, and/or pass through
Broadcast or other signal bearing medias in data flow and be transmitted, and/or be stored according to programmed instruction run calculating
In the working storage of machine equipment.Here, including a device according to one embodiment of present invention, the device is included for depositing
The memory and the processor for execute program instructions of computer program instructions are stored up, wherein, when the computer program instructions quilt
During the computing device, the methods and/or techniques side that the plant running is based on foregoing multiple embodiments of the invention is triggered
Case.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.Any reference in claim should not be considered as the claim involved by limitation.This
Outward, it is clear that " including " word is not excluded for other units or step, odd number is not excluded for plural number.The multiple stated in system claims
Unit or device can also be realized by a unit or device by software or hardware.The first, the second grade word is used for table
Show title, and be not offered as any specific order.
Claims (10)
1. a kind of scanning illuminating method for particle therapy, wherein, for every layer of object to be illuminated, methods described includes following
Step：
A obtains the point of irradiation distributed intelligence of the object to be illuminated；
B is based on the point of irradiation distributed intelligence to determine Current Scan path；
C is scanned according to the Current Scan path；
D performs optimization operation when predetermined end condition is not met based on the Current Scan path, to obtain optimization scanning road
Footpath, and the optimization scanning pattern is repeated into step c, d as Current Scan path.
2. method according to claim 1, wherein, the step d is further included：
- the Current Scan path is based on, using path optimization's algorithm, N number of obtained based on different random number according to predetermined
Scanning pattern optimum results, scanning irradiation process are divided into the multiple scanning irradiation process of corresponding number, respectively according to above-mentioned pre-
Fixed optimization scanning pattern implements n times multiple scanning irradiation.
3. method according to claim 2, wherein, path optimization's algorithm include it is following any one：
- simulated annealing；
- genetic algorithm.
4. according to the method in any one of claims 1 to 3, wherein, the predetermined end condition is based on following at least appointing
A kind of information determines：
- predetermined scanning times；
The realization convergence of-continuous optimization scanning pattern for obtaining.
5. method according to any one of claim 1 to 4, wherein, perform every time step c when institutes according to it is described current
Scanning pattern is incomplete same.
6. a kind of scanning means for particle therapy, wherein, for every layer of object to be illuminated, the scanning means includes：
Acquisition device, the point of irradiation distributed intelligence for obtaining the object to be illuminated；
Determining device, for determining Current Scan path based on the point of irradiation distributed intelligence；
Performs device, for being scanned according to the Current Scan path；
Optimization device, for when predetermined end condition is not met, optimization operation being performed based on the Current Scan path, to obtain
Must optimize scanning pattern, and using the optimization scanning pattern as Current Scan path, repeat the performs device and excellent
The operation that makeup is put.
7. scanning means according to claim 6, wherein, the performs device is further used for：
- the Current Scan path is based on, optimization operation is performed using path optimization's algorithm, to obtain optimization scanning pattern,
And optimize scanning pattern as Current Scan path using described.
8. scanning means according to claim 7, wherein, path optimization's algorithm include it is following any one：
- simulated annealing；
- genetic algorithm.
9. the scanning means according to any one of claim 6 to 8, wherein, the predetermined end condition include it is following extremely
Lack any one：
- reach predetermined scanning times；
The realization convergence of-continuous optimization scanning pattern for obtaining.
10. the scanning means according to any one of claim 6 to 9, wherein, each performs device institute according to described work as
Preceding scanning pattern is incomplete same.
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