CN106730247A - A kind of blood vessel interposing catheter - Google Patents
A kind of blood vessel interposing catheter Download PDFInfo
- Publication number
- CN106730247A CN106730247A CN201710064629.6A CN201710064629A CN106730247A CN 106730247 A CN106730247 A CN 106730247A CN 201710064629 A CN201710064629 A CN 201710064629A CN 106730247 A CN106730247 A CN 106730247A
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- China
- Prior art keywords
- conduit
- catheter body
- handle
- conduit handle
- organic solvent
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0008—Catheters; Hollow probes having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
- A61M2025/0046—Coatings for improving slidability
Abstract
The invention discloses a kind of blood vessel interposing catheter, including catheter body and conduit handle, one end of the catheter body and conduit handle detachable connection, other end inwall is embedded with stainless steel wire, subsidiary conduit handle is additionally provided with the conduit handle, and subsidiary conduit handle is provided with the tube chamber connected with conduit handle, haemostatic valve is installed on tube chamber, the catheter body surface is coated with lubricant coating.The present invention it is determined that conduit whether enter into anticipation target vessel section when need not extract seal wire out, can by subsidiary conduit handle connect syringe, from subsidiary conduit handle tube chamber by the gap between catheter body inwall and seal wire outer wall to Ink vessel transfusing inject contrast agent；The insertion position of conduit can also be directly observed by X-ray；The replacing of vagina vasorum can be carried out in the case where conduit is not withdrawn from, operating procedure is reduced, the risk of seal wire abjection is reduced；Lubricant coating being coated with catheter body surface and forming two layer coating system, coating both has hydrophilic lubrication performance, and with excellent anti-wear performance.
Description
Technical field
The invention belongs to technical field of medical instruments, more particularly to a kind of interposing catheter.
Background technology
It is technical field emerging in recent years that PCI is carried out to Ink vessel transfusing disease, and wherein interposing catheter is to implement this
One of critical medical apparatus of technology.When vascular interventional treatment is carried out, punctured on blood vessel with puncture needle, then will
Interposing catheter penetrates Ink vessel transfusing, then seal wire is inserted into interposing catheter from the conical opening of interposing catheter afterbody, sets up one from puncture
Track of the point at target vessel, interposing catheter is pushed ahead at target vessel along seal wire, finally extracts seal wire out
The inspection and treatment work of next step are carried out using the interposing catheter.
Current interposing catheter is mainly and is made up of catheter body and conduit handle, the afterbody of conduit cavity be provided with one it is close
Seal, sealing ring is made up of soft rubber, and the internal diameter of sealing ring is significantly less than the lumen diameter at other positions of conduit, also omits
The small external diameter in seal wire, the effect of sealing ring be after seal wire penetrates conduit, sealing ring can anti-Hemostatic Oral Liquid from conduit
Afterbody flows out.When intervention intubation is carried out after conduit enters into a certain vessel segment, if wanting to determine whether conduit enters
During to the target vessel section envisioned, it is necessary to extract seal wire out, then syringe is plugged at the taper hole of interposing catheter afterbody, pass through
Conduit is observed to Ink vessel transfusing injection contrast agent.If conduit insertion position it is improper, in addition it is also necessary to reinsert seal wire after
Continuous mobile conduit, it can be seen that such operation is very cumbersome.And, it is also easy in the rear tube for extracting seal wire out slotting from
Deviate from the vessel branch for entering, be unfavorable for disease treatment.
On the other hand, lubricity is also one of highly important performance of interposing catheter.When interposing catheter is entering, exiting blood
Pipe and when moving in the blood vessel, high-lubricity can suppress macromolecular such as plasma protein, blood platelet etc. in blood in material
The adhesion on surface, reduces the damage to vascular wall and haemocyte, mitigates the disturbance moved to blood laminar flow, while blood coagulation can be avoided anti-
The generation answered.Therefore, surface lubrication treatment is carried out to interposing catheter very necessary.
Therefore, how to solve the defect of above-mentioned prior art presence becomes the direction of art personnel effort.
The content of the invention
It is an object of the invention to provide a kind of blood vessel interposing catheter, can be fully solved above-mentioned the deficiencies in the prior art it
Place.
The purpose of the present invention is realized by following technical proposals：
A kind of blood vessel interposing catheter, including catheter body and conduit handle, one end of the catheter body are detachable with conduit handle
Connection, other end inwall is embedded with stainless steel wire, subsidiary conduit handle is additionally provided with the conduit handle, and subsidiary conduit handle is provided with
The tube chamber connected with conduit handle, is provided with haemostatic valve on tube chamber, and the catheter body surface is coated with lubricant coating.
Preferably, one end of the catheter body is provided with external thread section, and sets seal nipple on end face, conduit handle
End sets spacing back-up ring, and pivot bush unit fastener, and the fastener is provided with the interior spiral shell matched with external thread section on catheter body
Line, conduit handle is tightly inserted into the tube chamber of conduit handle by fastener and catheter body detachable connection, seal nipple.
Preferably, the seal nipple is the conical surface with the mating surface of conduit handle.
Preferably, opening up gasket groove on catheter body end face on the outside of the seal nipple, elasticity is installed in gasket groove
Packing ring, and the top surface of elastic washer is higher than notch.
Preferably, the catheter body is the flexible pipe being made of medical polyethylene, conduit handle is made of using polypropylene.
Preferably, the lubricant coating includes bottom and surface layer；The bottom includes polyglycidyl acrylate, contains
Side carboxyl polyurethane and organic solvent；Also, polyurethane containing side carboxyl is 1 with the mass ratio of polyglycidyl acrylate:
(0.2~0.8), the quality of organic solvent is the 80wt%~95wt% of the bottom gross mass；
The surface layer includes polymethyl vinyl ether-maleic anhydride, polyurethane containing side carboxyl and organic solvent；Also, contain
Side carboxyl polyurethane is 1 with the mass ratio of polymethyl vinyl ether-maleic anhydride:(0.2~0.8), the quality of organic solvent is
80wt%~the 95wt% of the top coat paint gross mass.
Preferably, the polyurethane containing side carboxyl in polyurethane containing side carboxyl and the bottom in the surface layer be by
Polyether/polyester dihydroxylic alcohols, diisocyanate, 2,2- dihydromethyl propionic acids and 1,4- butanediols are obtained through addition reaction；
The polyether/polyester dihydroxylic alcohols is in polyoxypropyleneglycol, PCDL and pla-pcl glycol
Kind, and the molecular weight of the polyether/polyester dihydroxylic alcohols is 1000~3000；
The diisocyanate is 2,4 toluene diisocyanate, hexa-methylene 1,6- diisocyanate and isophorone two
One kind in isocyanates.
Preferably, the organic solvent in organic solvent and the bottom in the surface layer is ethyl acetate, acetic acid
One or more in butyl ester, dichloromethane, chloroform, acetone, butanone and tetrahydrofuran.
A kind of method for preparing above-mentioned lubricant coating, comprises the following steps：
Step one, polyurethane containing side carboxyl is synthesized using solvent method：Polyether/polyester dihydroxylic alcohols and diisocyanate are added
In reactor, 70 DEG C~80 DEG C are warming up to, performed polymer is obtained after stirring 1h~2h；2,2- dihydroxy first is added in the reactor
Base propionic acid and BDO, after reaction 1h~2h, add ethyl acetate, continue to react 1h~2h, add tin dilaurate two
Butyl tin, reacts 10h~15h, is then down to room temperature；Solution in the reaction vessel is poured into the container equipped with deionized water
In, sediment is separated out, collect the sediment and be washed with deionized and dry afterwards several times；By the granulation of dried product,
Obtain polyurethane containing side carboxyl；
Step 2, prepares bottom：Side carboxyl polyurethane, polyglycidyl acrylate and organic solvent will be contained and be added to appearance
In device, 30min~50min is stirred at room temperature, obtains bottom；Wherein, polyurethane containing side carboxyl and polyacrylic acid glycidol
The mass ratio of ester is 1:(0.2~0.8), the quality of organic solvent is the 80wt%~95wt% of the bottom gross mass；
Step 3, prepares surface layer：Side carboxyl polyurethane, polymethyl vinyl ether-maleic anhydride and organic solvent will be contained to add
Enter in container, 30min~50min is stirred at room temperature, obtain top layer；Wherein, polyurethane containing side carboxyl and poly- ethylene methacrylic
The mass ratio of base ether-maleic anhydride is 1:(0.2~0.8), the quality of organic solvent be the 80wt% of the top layer gross mass~
95wt%.
Compared with prior art, the beneficial effects of the present invention are：
1. simple structure, reasonable in design, it is determined that conduit whether enter into anticipation target vessel section when need not extract seal wire out,
Syringe can be connected by subsidiary conduit handle, by subsidiary conduit handle tube chamber by between catheter body inwall and seal wire outer wall
Gap injects contrast agent to Ink vessel transfusing；The insertion position that conduit is directly observed by X-ray that can also be easier；
2. the replacing of vagina vasorum can be carried out in the case where conduit is not withdrawn from, operating procedure is reduced, seal wire is reduced
The risk of abjection, advantageously reduces operating time and risk；
3. it is coated with lubricant coating on catheter body surface and forms two layer coating system (formation bottom painting after subbing solidification
Layer, surface layer coating is formed after investment precoat solidification), it is anti-with the chemistry of acid anhydrides, epoxy and hydroxy-acid group in the two layer coating system
Answer mode to form many component cross-linked structures, make coating that both there is hydrophilic lubrication performance, and with excellent anti-wear performance.
Brief description of the drawings
Fig. 1 is structural representation of the invention；
Fig. 2 is the cross-sectional view of catheter body in Fig. 1；
Fig. 3 is the cross-sectional view of catheter body tail end in Fig. 1；
Fig. 4 is the attachment structure schematic diagram of catheter body and conduit handle in the present invention.
Specific embodiment
With reference to specific embodiments and the drawings, the present invention is further illustrated.
As shown in Figures 1 to 4, a kind of blood vessel interposing catheter, including catheter body 1, conduit handle 2 and subsidiary conduit handle 3, it is described
Catheter body 1 is the flexible pipe being made of medical polyethylene, and conduit handle 2 and subsidiary conduit handle 3 are made of using polypropylene.
One end of the catheter body 1 and the detachable connection of conduit handle 2, other end inwall are embedded with stainless steel wire 4, referring to
Fig. 3.Subsidiary conduit handle 3 is additionally provided with the conduit handle 2, and subsidiary conduit handle 3 is provided with the tube chamber connected with conduit handle 2,
Haemostatic valve 5 is installed, the surface of the catheter body 1 is coated with lubricant coating on tube chamber.Sealing ring 6 is provided with conduit handle 2, and it is close
Seal 6 is located at the rear of subsidiary conduit handle 3 and the connectivity part of conduit handle 2, it is to avoid influence injects contrast agent by subsidiary conduit handle 3.
Referring to Fig. 4, one end of the catheter body 1 is provided with external thread section, and seal nipple 7, conduit handle 2 are set on end face
End spacing back-up ring 8, and pivot bush unit fastener 9 are set, the fastener 9 is provided with and is matched with external thread section on catheter body 1
Internal thread, conduit handle 2 is tightly inserted into the pipe of conduit handle 2 by fastener 9 and the detachable connection of catheter body 1, seal nipple 7
In chamber.Also, in order to strengthen sealing effectiveness, the seal nipple 7 is the conical surface with the mating surface of conduit handle 2.
In order to strengthen the tightness that conduit handle 2 is connected with catheter body 1, on the end face of catheter body 1 in the outside of the seal nipple 7
Gasket groove is opened up, elastic washer 10 is installed in gasket groove, and the top surface of elastic washer 10 is higher than notch.
Using preceding, it is threadedly coupled with the external thread section on catheter body 1 by turn Fastener 9 until fastener 9 is limited
Position back-up ring 8 is spacing so that be in close contact with catheter body 1 in the tube chamber of the insertion catheter body 1 of seal nipple 7 of the end of conduit handle 2, this
When catheter body 1 connected as one with conduit handle 2.
When it is determined that whether catheter body 1 enters into the target vessel section of anticipation, without extracting seal wire out, can be by subsidiary conduit
Handle 3 connects syringe, is noted to Ink vessel transfusing by the gap between the inwall of catheter body 1 and seal wire outer wall from the tube chamber of subsidiary conduit handle 3
Enter contrast agent；The insertion that catheter body 1 is directly observed by the X-ray position of the stainless steel wire 4 of the front inner wall of catheter body 1 can also be utilized
Put.
Because catheter body 1 and conduit handle 2 are detachable connection, vagina vasorum can be carried out in the case where conduit is not withdrawn from
Replacing, reduce operating procedure, reduce seal wire abjection risk, advantageously reduce operating time and risk.
The lubricant coating of the surface of the catheter body 1 coating includes bottom 11 and surface layer 12, referring to Fig. 2.The bottom 11 is wrapped
Containing polyglycidyl acrylate, polyurethane containing side carboxyl and organic solvent；Also, polyurethane containing side carboxyl contracts with polyacrylic acid
The mass ratio of water glyceride is 1:(0.2~0.8), the quality of organic solvent be the 80wt% of the bottom gross mass~
95wt%.The surface layer 12 includes polymethyl vinyl ether-maleic anhydride, polyurethane containing side carboxyl and organic solvent；Also, contain
Side carboxyl polyurethane is 1 with the mass ratio of polymethyl vinyl ether-maleic anhydride:(0.2~0.8), the quality of organic solvent is
80wt%~the 95wt% of the top coat paint gross mass.
The polyurethane containing side carboxyl in polyurethane containing side carboxyl and the bottom 11 in the surface layer 12 be by polyethers/
Polyester diol, diisocyanate, 2,2- dihydromethyl propionic acids and 1,4- butanediols are obtained through addition reaction；The polyethers/poly-
Ester dihydroxylic alcohols is the one kind in polyoxypropyleneglycol, PCDL and pla-pcl glycol, and the polyether/polyester two
The molecular weight of first alcohol is 1000~3000；The diisocyanate is 2,4 toluene diisocyanate, hexa-methylene 1,6- bis- is different
One kind in cyanate and isoflurane chalcone diisocyanate.
The organic solvent in organic solvent and the bottom 11 in the surface layer 12 be ethyl acetate, butyl acetate,
One or more in dichloromethane, chloroform, acetone, butanone and tetrahydrofuran.
A kind of method for preparing above-mentioned lubricant coating, comprises the following steps：
Step one, polyurethane containing side carboxyl is synthesized using solvent method：Polyether/polyester dihydroxylic alcohols and diisocyanate are added
In reactor, 70 DEG C~80 DEG C are warming up to, performed polymer is obtained after stirring 1h~2h；2,2- dihydroxy first is added in the reactor
Base propionic acid and BDO, after reaction 1h~2h, add ethyl acetate, continue to react 1h~2h, add tin dilaurate two
Butyl tin, reacts 10h~15h, is then down to room temperature；Solution in the reaction vessel is poured into the container equipped with deionized water
In, sediment is separated out, collect the sediment and be washed with deionized and dry afterwards several times；By the granulation of dried product,
Obtain polyurethane containing side carboxyl；
Step 2, prepares bottom：Side carboxyl polyurethane, polyglycidyl acrylate and organic solvent will be contained and be added to appearance
In device, 30min~50min is stirred at room temperature, obtains bottom；Wherein, polyurethane containing side carboxyl and polyacrylic acid glycidol
The mass ratio of ester is 1:(0.2~0.8), the quality of organic solvent is the 80wt%~95wt% of the bottom gross mass；
Step 3, prepares surface layer：Side carboxyl polyurethane, polymethyl vinyl ether-maleic anhydride and organic solvent will be contained to add
Enter in container, 30min~50min is stirred at room temperature, obtain top layer；Wherein, polyurethane containing side carboxyl and poly- ethylene methacrylic
The mass ratio of base ether-maleic anhydride is 1:(0.2~0.8), the quality of organic solvent be the 80wt% of the top layer gross mass~
95wt%.
When the catheter body surface of interposing catheter coats above-mentioned lubricant coating, first by subbing spraying or brush
Mode is coated to catheter body surface, and 30min~50min is solidified at 50 DEG C~60 DEG C；Then investment precoat is coated to having applied
Have on the catheter body of subbing, 40min~80min is solidified at 50 DEG C~60 DEG C, obtain to outer surface and be coated with cross-linked structure
The interposing catheter of coating.
In order that obtaining catheter body has more preferable hydrophilicity, also need to carry out hydrophilic treated to cross-linked structure coating, will
The catheter body that outer surface is coated with cross-linked structure coating is immersed into concentrated ammonia liquor, and 40min~80min is soaked at room temperature, is taken out
1h~2h is dried at 50 DEG C~70 DEG C, you can obtaining surface has the catheter body of excellent hydrophilic lubrication performance afterwards.
The present invention is coated with lubricant coating formation two layer coating system and (forms bottom after subbing solidification on catheter body surface
Layer coating, surface layer coating is formed after investment precoat solidification), in the two layer coating system, with the change of acid anhydrides, epoxy and hydroxy-acid group
Learn reactive mode and form many component cross-linked structures, make coating that both there is hydrophilic lubrication performance, and with excellent anti-wear performance.Profit
Sliding coating makes the suffered frictional force reduction by more than 90% in water environment of interposing catheter；And coating is remained to after rubbing action repeatedly
Complete, suffered in water environment frictional force increasing degree is kept to be no more than 5%.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in essence of the invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of blood vessel interposing catheter, including catheter body and conduit handle, it is characterised in that：One end of the catheter body and conduit handle
Detachable connection, other end inwall is embedded with stainless steel wire, and subsidiary conduit handle, and subsidiary conduit are additionally provided with the conduit handle
Handle is provided with the tube chamber connected with conduit handle, and haemostatic valve is provided with tube chamber, and the catheter body surface is coated with lubricant coating.
2. blood vessel interposing catheter according to claim 1, it is characterised in that：One end of the catheter body is provided with external screw thread
Section, and seal nipple is set on end face, the end of conduit handle sets spacing back-up ring, and pivot bush unit fastener, the fastening
Part is provided with the internal thread matched with external thread section on catheter body, and conduit handle is close by fastener and catheter body detachable connection
Sealing joint is tightly inserted into the tube chamber of conduit handle.
3. blood vessel interposing catheter according to claim 2, it is characterised in that：The mating surface of the seal nipple and conduit handle
It is the conical surface.
4. blood vessel interposing catheter according to claim 2, it is characterised in that：Catheter body end face on the outside of the seal nipple
On open up gasket groove, elastic washer is installed in gasket groove, and the top surface of elastic washer is higher than notch.
5. blood vessel interposing catheter according to claim 2, it is characterised in that：The catheter body is using medical polyethylene system
Into flexible pipe, conduit handle is made of using polypropylene.
6. the blood vessel interposing catheter according to claim any one of 1-5, it is characterised in that:The lubricant coating includes bottom
And surface layer；
The bottom includes polyglycidyl acrylate, polyurethane containing side carboxyl and organic solvent；Also, containing the poly- ammonia of side carboxyl
Ester is 1 with the mass ratio of polyglycidyl acrylate:(0.2~0.8), the quality of organic solvent is the bottom gross mass
80wt%~95wt%；
The surface layer includes polymethyl vinyl ether-maleic anhydride, polyurethane containing side carboxyl and organic solvent；Also, carboxylic containing side
Based polyurethanes are 1 with the mass ratio of polymethyl vinyl ether-maleic anhydride:(0.2~0.8), the quality of organic solvent is described
80wt%~the 95wt% of top coat paint gross mass.
7. blood vessel interposing catheter according to claim 6, it is characterised in that：Polyurethane containing side carboxyl in the surface layer and
Polyurethane containing side carboxyl in the bottom be by polyether/polyester dihydroxylic alcohols, diisocyanate, 2,2- dihydromethyl propionic acids and
1,4- butanediols are obtained through addition reaction；
The polyether/polyester dihydroxylic alcohols is the one kind in polyoxypropyleneglycol, PCDL and pla-pcl glycol, and
The molecular weight of the polyether/polyester dihydroxylic alcohols is 1000~3000；
The diisocyanate is 2,4 toluene diisocyanate, hexa-methylene 1,6- diisocyanate and the isocyanide of isophorone two
One kind in acid esters.
8. blood vessel interposing catheter according to claim 6, it is characterised in that：Organic solvent and the bottom in the surface layer
Organic solvent in layer is in ethyl acetate, butyl acetate, dichloromethane, chloroform, acetone, butanone and tetrahydrofuran
One or more.
9. a kind of method for preparing lubricant coating described in claim 7 or 8, it is characterised in that comprise the following steps：
Step one, polyurethane containing side carboxyl is synthesized using solvent method：Polyether/polyester dihydroxylic alcohols and diisocyanate are added into reaction
In device, 70 DEG C~80 DEG C are warming up to, performed polymer is obtained after stirring 1h~2h；2,2- dihydroxymethyls third are added in the reactor
Acid and BDO, after reaction 1h~2h, add ethyl acetate, continue to react 1h~2h, add di lauric dibutyl
Tin, reacts 10h~15h, is then down to room temperature；Solution in the reaction vessel is poured into the container equipped with deionized water,
Sediment is separated out, the sediment is collected and is washed with deionized and dry afterwards several times；By the granulation of dried product, obtain
Polyurethane containing side carboxyl；
Step 2, prepares bottom：Side carboxyl polyurethane, polyglycidyl acrylate and organic solvent will be contained and be added to container
In, 30min~50min is stirred at room temperature, obtain bottom；Wherein, polyurethane containing side carboxyl and polyglycidyl acrylate
Mass ratio be 1:(0.2~0.8), the quality of organic solvent is the 80wt%~95wt% of the bottom gross mass；
Step 3, prepares surface layer：Side carboxyl polyurethane, polymethyl vinyl ether-maleic anhydride and organic solvent will be contained to be added to
In container, 30min~50min is stirred at room temperature, obtains top layer；Wherein, polyurethane containing side carboxyl and polymethyl vinyl ether-
The mass ratio of maleic anhydride is 1:(0.2~0.8), the quality of organic solvent be the 80wt% of the top layer gross mass~
95wt%.
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| CN201710064629.6A CN106730247A (en) | 2017-02-04 | 2017-02-04 | A kind of blood vessel interposing catheter |
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| CN201710064629.6A CN106730247A (en) | 2017-02-04 | 2017-02-04 | A kind of blood vessel interposing catheter |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107261297A (en) * | 2017-08-01 | 2017-10-20 | 郑州大学第附属医院 | The interposing catheter of multistage controlled deflection |
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Application publication date: 20170531 |