CN106728529A - 一种能防治兔子鼻炎的药物 - Google Patents
一种能防治兔子鼻炎的药物 Download PDFInfo
- Publication number
- CN106728529A CN106728529A CN201710115394.9A CN201710115394A CN106728529A CN 106728529 A CN106728529 A CN 106728529A CN 201710115394 A CN201710115394 A CN 201710115394A CN 106728529 A CN106728529 A CN 106728529A
- Authority
- CN
- China
- Prior art keywords
- rabbit
- medicine
- rhinitis
- reinforcing agent
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000283973 Oryctolagus cuniculus Species 0.000 title claims abstract description 56
- 239000003814 drug Substances 0.000 title claims abstract description 52
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 42
- 239000012744 reinforcing agent Substances 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 241000596154 Belamcanda Species 0.000 claims abstract description 17
- 229920001491 Lentinan Polymers 0.000 claims abstract description 17
- 241000521581 Millettia Species 0.000 claims abstract description 17
- 241000219784 Sophora Species 0.000 claims abstract description 17
- 240000008488 Thlaspi arvense Species 0.000 claims abstract description 17
- 235000008214 Thlaspi arvense Nutrition 0.000 claims abstract description 17
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 17
- 239000010440 gypsum Substances 0.000 claims abstract description 17
- 229940115286 lentinan Drugs 0.000 claims abstract description 17
- 239000009636 Huang Qi Substances 0.000 claims abstract description 16
- 244000179560 Prunella vulgaris Species 0.000 claims abstract description 16
- 244000226566 Psoralea corylifolia Species 0.000 claims abstract description 16
- 241000218989 Trichosanthes Species 0.000 claims abstract description 16
- 235000008113 selfheal Nutrition 0.000 claims abstract description 16
- 101100002917 Caenorhabditis elegans ash-2 gene Proteins 0.000 claims abstract description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000001914 filtration Methods 0.000 claims description 14
- 239000012530 fluid Substances 0.000 claims description 14
- 235000012907 honey Nutrition 0.000 claims description 14
- 238000002386 leaching Methods 0.000 claims description 14
- 239000011782 vitamin Substances 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 241000206607 Porphyra umbilicalis Species 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 229930003451 Vitamin B1 Natural products 0.000 claims description 2
- 229960003495 thiamine Drugs 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- 235000010374 vitamin B1 Nutrition 0.000 claims description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 241000700605 Viruses Species 0.000 abstract description 8
- 230000001976 improved effect Effects 0.000 abstract description 5
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000013019 agitation Methods 0.000 description 5
- 238000007654 immersion Methods 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 229930003231 vitamin Natural products 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- 210000001331 nose Anatomy 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 206010065334 Mucosal hyperaemia Diseases 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 206010044074 Torticollis Diseases 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 208000018197 inherited torticollis Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 201000005261 otitis interna Diseases 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于药物技术领域,尤其涉及一种能防治兔子鼻炎的药物;由以下按重量份计的原料组成:山豆根10~20、天花粉8~12、石榴皮5~8、鸡血藤10~15、败酱草12~18、秦皮2~5、射干1~3、补骨脂4~7、夏枯草6~10、黄芪10~15、石膏2~4、香菇多糖3~5、增强剂8~12;本发明药物科学、合理,原料丰富,成本低,易生产,无毒副作用,服用方便,有效用于治疗兔子鼻炎,有效抑制发病兔体内的病毒,减少对其他健康兔的传染,提升自身抵抗力,降低感染病毒细菌的风险,显著提高兔子的存活率,提高养殖收益。
Description
技术领域
本发明属于药物技术领域,尤其涉及一种能防治兔子鼻炎的药物。
背景技术
鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症,鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等,病毒感染是其首要病因,或在病毒感染的基础上继发细菌感染。已知有100多种病毒可引起本病,最常见的是鼻病毒,其次是流感和副流感病毒、腺病毒、冠状病毒、柯萨奇病毒及黏液和副黏液病毒等。病毒传播方式主要是经过呼吸道吸入,其次是通过被污染体或食物进入机体,一旦感染发病的话,会变得没有精神,静止不动的时间会增加,开始打喷涕,且连续打喷涕的次数会变多,若内耳感染的话,则会引发斜颈,若更进一步内脏感染的话,甚至会造成死亡。
在现有技术中,西医上常采用抗生素等药物进行治疗,但是,西医治疗鼻炎疗程较长,病情不易得到及时控制,甚至延误病情治疗效果往往不理想,无特异疗法,为恢复健康,阻止病情恶化,防止继发感染,病后只能采取对症下药,无法提前预防;且西药的副作用比较大。中医学认为,认为鼻炎的本质是正气不足,无力祛邪,大多因脏腑功能失调,再加上外感风寒,邪气侵袭鼻窍而致,鼻炎患者往往会出现鼻中有黄涕,或者鼻痒,鼻热等表现,近年来,由于中医疗法具有副作用小,抗复发率效果好,能稳定病情,不扩散的特点,使得其在鼻炎领域得到了快速的应用和推广,目前国内有研究治疗鼻炎的中药配方,并取得了一定的成效,但是,由于现有技术中的中医配方不合理,原料成分不恰当,导致中医治疗效果不明显,病情不能得到良好的控制,还对兔子机体造成损害,严重影响兔子养殖业的发展,所以,针对这种高发的鼻炎疾病,发展中药治疗鼻炎是很有必要的。
发明内容
为了解决上述技术问题,本发明提供一种能防治兔子鼻炎的药物。
具体是这样实现的:
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根10~20、天花粉8~12、石榴皮5~8、鸡血藤10~15、败酱草12~18、秦皮2~5、射干1~3、补骨脂4~7、夏枯草6~10、黄芪10~15、石膏2~4、香菇多糖3~5、增强剂8~12。
优选地,由以下按重量份计的原料组成:山豆根15、天花粉10、石榴皮7、鸡血藤13、败酱草15、秦皮3、射干2、补骨脂5、夏枯草8、黄芪13、石膏3、香菇多糖4、增强剂10。
进一步,所述的增强剂,由以下按重量份计的原料组成:蜂蜜15~20、维生素D1~2、维生素B1~3、低聚果糖5~8、紫菜粉8~12,其中,蜂蜜的含水量为20~25%。
进一步,所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎10~15min,加入混合总重量的5倍的乙醇浸泡10~12h,回收乙醇,过滤;将滤液与盐酸按1∶0.08~0.1的体积比混合,磁力搅拌器搅拌8~12min,得草本处理液;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.2~1.5h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的丙酮,加热回流3次,每次回流20~30min,减压回收丙酮,将残余液在40~50KHz的频率下超声处理10~13min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在40~50℃的恒温水浴中,磁力搅拌器搅拌30~40min。
进一步,所述的盐酸,其浓度为2.5~3%。
进一步,所述的乙醇,其浓度为85~90%,所述的丙酮,其浓度为2~3%。
进一步,所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.1~0.2∶2的质量比混合,即可。
综上所述,本发明的有益效果在于:本发明药物科学、合理,原料丰富,成本低,易生产,无毒副作用,服用方便,有效用于治疗兔子鼻炎,效果显著,对发病1d的病兔,完全治愈率达到99%,发病2~3d的病兔,完全治愈率达到99.2%,发病3d以上的病兔,完全治愈率达到99%,有效抑制发病兔体内的病毒,减少对其他健康兔的传染,提升自身抵抗力,降低感染病毒细菌的风险,显著提高兔子的存活率,提高养殖收益。
本发明药物,能有效的提高兔子机体的免疫力,提高对疾病的免疫抵抗力,其中包含了清热解毒、消炎杀菌的中药,还包括能促进免疫系统发育完善的中药,还包括抗菌抗病毒的中药成份,还包括补气的中药成份,通过特定的工艺,各组分之间通过协同增效的作用,有效的针对诱发鼻炎的病毒细菌进行防治,预防和治疗效果显著。
具体实施方式
下面对本发明的具体实施方式作进一步详细的说明,但本发明并不局限于这些实施方式,任何在本实施例基本精神上的改进或代替,仍属于本发明权利要求所要求保护的范围。
实施例1
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根10kg、天花粉8kg、石榴皮5kg、鸡血藤10kg、败酱草12kg、秦皮2kg、射干1kg、补骨脂4kg、夏枯草6kg、黄芪10kg、石膏2kg、香菇多糖3kg、增强剂8kg。
所述的增强剂,由以下按重量份计的原料组成:蜂蜜15kg、维生素D1kg、维生素B1kg、低聚果糖5kg、紫菜粉8kg,其中,蜂蜜的含水量为20%。
所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎10min,加入混合总重量的5倍的85%的乙醇浸泡10h,回收乙醇,过滤;将滤液与盐酸按1∶0.08的体积比混合,磁力搅拌器搅拌8min,得草本处理液,其中所述的盐酸,其浓度为2.5%;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.2h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的2%的丙酮,加热回流3次,每次回流20min,减压回收丙酮,将残余液在40KHz的频率下超声处理10min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在40℃的恒温水浴中,磁力搅拌器搅拌30min。
所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.1∶2的质量比混合,即可。
实施例2
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根20kg、天花粉12kg、石榴皮8kg、鸡血藤15kg、败酱草18kg、秦皮5kg、射干3kg、补骨脂7kg、夏枯草10kg、黄芪15kg、石膏4kg、香菇多糖5kg、增强剂12kg。
所述的增强剂,由以下按重量份计的原料组成:蜂蜜20kg、维生素D2kg、维生素B3kg、低聚果糖8kg、紫菜粉12kg,其中,蜂蜜的含水量为25%。
所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎15min,加入混合总重量的5倍的90%的乙醇浸泡12h,回收乙醇,过滤;将滤液与盐酸按1∶0.1的体积比混合,磁力搅拌器搅拌12min,得草本处理液,其中所述的盐酸,其浓度为3%;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.5h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的3%的丙酮,加热回流3次,每次回流30min,减压回收丙酮,将残余液在50KHz的频率下超声处理13min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在50℃的恒温水浴中,磁力搅拌器搅拌40min。
所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.2∶2的质量比混合,即可。
实施例3
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根15kg、天花粉10kg、石榴皮7kg、鸡血藤13kg、败酱草15kg、秦皮3kg、射干2kg、补骨脂5kg、夏枯草8kg、黄芪13kg、石膏3kg、香菇多糖4kg、增强剂10kg。
所述的增强剂,由以下按重量份计的原料组成:蜂蜜18kg、维生素D1.5kg、维生素B2kg、低聚果糖7kg、紫菜粉10kg,其中,蜂蜜的含水量为23%。
所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎13min,加入混合总重量的5倍的88%的乙醇浸泡11h,回收乙醇,过滤;将滤液与盐酸按1∶0.09的体积比混合,磁力搅拌器搅拌10min,得草本处理液,其中所述的盐酸,其浓度为2.8%;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.3h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的2.5%的丙酮,加热回流3次,每次回流25min,减压回收丙酮,将残余液在45KHz的频率下超声处理11min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在45℃的恒温水浴中,磁力搅拌器搅拌35min。
所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.15∶2的质量比混合,即可。
实施例4
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根10kg、天花粉12kg、石榴皮5kg、鸡血藤15kg、败酱草12kg、秦皮5kg、射干1kg、补骨脂7kg、夏枯草6kg、黄芪15kg、石膏2kg、香菇多糖5kg、增强剂kgkg。
所述的增强剂,由以下按重量份计的原料组成:蜂蜜20kg、维生素D1kg、维生素B3kg、低聚果糖5kg、紫菜粉12kg,其中,蜂蜜的含水量为20%。
所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎10min,加入混合总重量的5倍的90%的乙醇浸泡10h,回收乙醇,过滤;将滤液与盐酸按1∶0.08的体积比混合,磁力搅拌器搅拌12min,得草本处理液,其中所述的盐酸,其浓度为2.5%;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.2h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的3%的丙酮,加热回流3次,每次回流20min,减压回收丙酮,将残余液在50KHz的频率下超声处理10min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在40℃的恒温水浴中,磁力搅拌器搅拌30min。
所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.2∶2的质量比混合,即可。
实施例5
一种能防治兔子鼻炎的药物,由以下按重量份计的原料组成:山豆根10kg、天花粉8kg、石榴皮5kg、鸡血藤15kg、败酱草18kg、秦皮5kg、射干1kg、补骨脂4kg、夏枯草6kg、黄芪15kg、石膏4kg、香菇多糖5kg、增强剂12kg。
所述的增强剂,由以下按重量份计的原料组成:蜂蜜15kg、维生素D1kg、维生素B1kg、低聚果糖8kg、紫菜粉12kg,其中,蜂蜜的含水量为20%。
所述的能防治兔子鼻炎的药物,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎10min,加入混合总重量的5倍的90%的乙醇浸泡10h,回收乙醇,过滤;将滤液与盐酸按1∶0.08的体积比混合,磁力搅拌器搅拌8min,得草本处理液,其中所述的盐酸,其浓度为3%;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.2h后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的3%的丙酮,加热回流3次,每次回流20min,减压回收丙酮,将残余液在40KHz的频率下超声处理10min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在40℃的恒温水浴中,磁力搅拌器搅拌40min。
所述的能防治兔子鼻炎的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.18∶2的质量比混合,即可。
实验例
1、由A、B、C分别表示治疗情况,其中A表示没有效果,兔子的病情无好转,严重者出现死亡现象,C表示有效,症状完全消失,恢复到病前的状态,B表示症状基本控制住,有待继续用药治疗。
选择某兔子养殖基地为试验地,其中发病1d的有100只,发病2~3d的有125只,发病3d以上的的有200只,试验时间为4d,分别统计效果,结果如表1所示:
表1
发病时间 | C(%) | B(%) | A(%) |
1d | 99 | 1 | 0 |
2~3d | 99.2 | 0.8 | 0 |
3d以上 | 99 | 1 | 0 |
2、选取1000只兔子,雌雄各半,随机分为两组,其中实验组在日粮中添加本发明药物,对照组不添加药物,其中两组兔子均由同一人饲养,对两组兔子的发病情况进行统计,结果如表2所示:
表2
说明,表2中的治疗药物使用次数,是指发病后,采用市售的治疗鼻炎的西药的使用次数。
Claims (7)
1.一种能防治兔子鼻炎的药物,其特征在于,由以下按重量份计的原料组成:山豆根10~20、天花粉8~12、石榴皮5~8、鸡血藤10~15、败酱草12~18、秦皮2~5、射干1~3、补骨脂4~7、夏枯草6~10、黄芪10~15、石膏2~4、香菇多糖3~5、增强剂8~12。
2.如权利要求1所述的能防治兔子鼻炎的药物,其特征在于,由以下按重量份计的原料组成:山豆根15、天花粉10、石榴皮7、鸡血藤13、败酱草15、秦皮3、射干2、补骨脂5、夏枯草8、黄芪13、石膏3、香菇多糖4、增强剂10。
3.如权利要求1所述的能防治兔子鼻炎的药物,其特征在于,所述的增强剂,由以下按重量份计的原料组成:蜂蜜15~20、维生素D1~2、维生素B1~3、低聚果糖5~8、紫菜粉8~12,其中,蜂蜜的含水量为20~25%。
4.如权利要求1所述的能防治兔子鼻炎的药物,其特征在于,其制备方法,包括以下步骤:
(1)将鸡血藤、败酱草、补骨脂、夏枯草、黄芪混合,捣碎10~15min,加入混合总重量的5倍的乙醇浸泡10~12h,回收乙醇,过滤;将滤液与盐酸按1:0.08~0.1的体积比混合,磁力搅拌器搅拌8~12min,得草本处理液;
(2)将山豆根、天花粉、石榴皮、秦皮、射干按配方称取,加水,熬煮,1.2~1.Sh后,过滤,将滤液浓缩至滤液体积的1/3,加入浓缩液5倍质量的丙酮,加热回流3次,每次回流20~30min,减压回收丙酮,将残余液在40~50KHz的频率下超声处理10~13min,得浸提液;
(3)将草本处理液、浸提液和石膏、香菇多糖、增强剂混合,在40~50℃的恒温水浴中,磁力搅拌器搅拌30~40min。
5.如权利要求4所述的能防治兔子鼻炎的药物,其特征在于,所述的盐酸,其浓度为2.5~3%。
6.如权利要求4所述的能防治兔子鼻炎的药物,其特征在于,所述的乙醇,其浓度为85~90%,所述的丙酮,其浓度为2~3%。
7.如权利要求1~6所述的能防治兔子鼻炎的药物,其特征在于,所述的药物,使用方法是,早中晚各服用一次,每次服用将药物和兔饲料按0.1~0.2∶2的质量比混合,即可。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710115394.9A CN106728529A (zh) | 2017-02-28 | 2017-02-28 | 一种能防治兔子鼻炎的药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710115394.9A CN106728529A (zh) | 2017-02-28 | 2017-02-28 | 一种能防治兔子鼻炎的药物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106728529A true CN106728529A (zh) | 2017-05-31 |
Family
ID=58960187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710115394.9A Pending CN106728529A (zh) | 2017-02-28 | 2017-02-28 | 一种能防治兔子鼻炎的药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106728529A (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105709081A (zh) * | 2014-12-02 | 2016-06-29 | 北京大北农动物保健科技有限责任公司 | 治疗鸡传染性鼻炎的药物组合物,其应用及饲料 |
CN106620196A (zh) * | 2017-01-24 | 2017-05-10 | 广西山水牛农业有限责任公司 | 一种能治疗牛口蹄疫病的药物 |
CN106668817A (zh) * | 2017-01-24 | 2017-05-17 | 广西山水牛农业有限责任公司 | 一种能治疗牛流行热病的药物 |
-
2017
- 2017-02-28 CN CN201710115394.9A patent/CN106728529A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105709081A (zh) * | 2014-12-02 | 2016-06-29 | 北京大北农动物保健科技有限责任公司 | 治疗鸡传染性鼻炎的药物组合物,其应用及饲料 |
CN106620196A (zh) * | 2017-01-24 | 2017-05-10 | 广西山水牛农业有限责任公司 | 一种能治疗牛口蹄疫病的药物 |
CN106668817A (zh) * | 2017-01-24 | 2017-05-17 | 广西山水牛农业有限责任公司 | 一种能治疗牛流行热病的药物 |
Non-Patent Citations (1)
Title |
---|
王海荣主编: "《兔常见病诊断与防治》", 31 March 2014, 金盾出版社 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102114197A (zh) | 一种治疗流行性感冒的中药口服汤剂 | |
CN103330865B (zh) | 一种治疗非酒精性脂肪性肝炎的药物及制备方法 | |
CN101972418A (zh) | 一种预防和治疗感冒的保健茶 | |
CN106421505A (zh) | 一种防治甲鱼白底板病的组合物 | |
CN106728529A (zh) | 一种能防治兔子鼻炎的药物 | |
CN103100072B (zh) | 治疗直肠炎、盲肠炎和抑制直肠癌的中药组合物 | |
CN102727848B (zh) | 治疗家禽传染性法氏囊病的纯中药组合物及其制备方法 | |
CN102988885B (zh) | 一种治疗胆囊炎中药 | |
CN102935149B (zh) | 一种治疗家畜呼吸道疾病的组合物及其制备方法 | |
CN102357148B (zh) | 一种治疗鸭疫里默氏杆菌病的纯中药组合物及其制备方法 | |
CN105477484A (zh) | 一种治疗过敏性哮喘的药物 | |
CN105381020A (zh) | 一种治疗风湿骨痛的外用药物 | |
CN104667242A (zh) | 一种治疗甲型h1n1流感的胶囊及其制备方法 | |
CN104524107A (zh) | 用于风寒湿痹证的中成药 | |
CN103536673B (zh) | 兼具强力增强免疫力的消积退热止咳喘外用散及其应用 | |
CN103933183B (zh) | 一种有效治疗大便秘结的中药制剂 | |
CN103585330B (zh) | 一种用于皮肤真菌感染的中药组合物及其制备方法 | |
CN107693768A (zh) | 一种治疗哮喘的中药制剂 | |
CN107441424A (zh) | 一种治疗肺结核的药物及其制备方法 | |
CN107715085A (zh) | 一种治疗慢性结肠炎的中药组合物 | |
CN105148101A (zh) | 一种治疗钩虫病的中药制剂及其制备方法 | |
CN104027751A (zh) | 治疗慢性胆囊炎的中药制剂 | |
CN104042800A (zh) | 一种治疗单纯疱疹的复方中药制剂及其制备方法 | |
CN102961516B (zh) | 治疗鸭病毒性肝炎的纯中药组合物及其制备方法 | |
CN104161835A (zh) | 一种治疗痰热咳嗽的中药 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |