CN106728126A - Inflammation disappear enlightening Na youngster pharmaceutical composition prepare treatment cholestatic jaundice medicine in application - Google Patents
Inflammation disappear enlightening Na youngster pharmaceutical composition prepare treatment cholestatic jaundice medicine in application Download PDFInfo
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Abstract
Inflammation disappears application of the enlightening Na youngster pharmaceutical composition in treatment cholestatic jaundice medicine is prepared, and disappears enlightening Na youngster's pharmaceutical composition the invention discloses a kind of inflammation.The inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root, witloof, rose, rheum officinale, oral shui solution, oxtongue, Semen Cuscutae, the inflammation disappear enlightening Na youngster pharmaceutical composition for treating cholestatic jaundice.The inflammation enlightening Na youngster pharmaceutical composition that disappears not only has good therapeutic effect to cholestatic jaundice, can also treat various hepatitis, cholecystitis and urinary tract infections.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular it relates to inflammation disappears enlightening Na youngster pharmaceutical composition and its prepare treatment cholestatic
Application in jaundice medicine.
Background technology
ChJ refers to that bile acid and bilirubin are above normal value in making blood because of cholestasia.It is general to produce bile
The cause of disease of alluvial has infection, metabolism, immune and other (such as cirrhosis, liver cancer).Due to thin in various causes of disease infringement liver cell
Born of the same parents' device, blocks cholangiole in liver cell and/or bile capillaries bile excretion obstacle or liver, causes intrahepatic cholestasis, causes
Hepatic injury.Performance is different and different from property with the cause of disease, obstructive position.Mainly there is jaundice, skin disturbs sample and poor appetite, weak
Etc. phenomenon.
At present, preferable drug therapy cholestatic jaundice is there is no, therefore, the medicine for treating cholestatic jaundice awaits
Further research.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art.Therefore, it is an object of the present invention to carry
Go out a kind of medicine of effective treatment cholestatic jaundice.
It should be noted that the present invention is to be based on the following work of inventor and complete：
Cholestatic jaundice can cause the change of body multisystem, including central nervous system dysfunction, secondary biliary
Under cirrhosis, hepatic injury, hepatocellular apoptosis, steatorrhea, endotoxemia, bradycardia, myocardial contractive power decline, blood pressure
Drop, renal insufficiency, immune dysfunction etc..
At present in the clinical treatment of cholestatic jaundice, mainly based on Western medicine, such as phenobarbital, lactulose, magnesium sulfate
Deng, glucocorticoid medicine, such as dexamethasone, metacortandracin, but the toxic and side effect of said medicine is big, and adverse reaction is obvious.
The phenobarbital course for the treatment of is long, and dyshepatia person is used with caution, especially differentiates that not clear person uses with caution to chronic cholestatic and liver cirrhosis patient
With without.Lactulose, magnesium sulfate etc. increase the medicine that bilirubin discharges enteron aisle, are often accompanied by diarrhoea, easily cause cylinder electrolyte disorderly
Disorderly；Glucocorticoid medicine, toxic and side effect is big, long-term taking, easily causes the hyperfunction syndrome of cortex hormone function, and induce or add
Double infection dye, canker, hypertension and artery sclerosis etc..Therefore, the most poison of the medicine for the treatment of cholestatic jaundice is secondary at present makees
With big, the long-term taking of medicine is limited, influence the clinical practice of medicine.
Inflammation disappear enlightening Na youngster's syrup be tradition dimension medicine, wherein, oxtongue property is damp and hot, function life humidogene heat, the black bile of dysregulation；
Oral shui solution is two grades raw, the ripe exception bile matter of function, drops hot nourishing the liver；Semen Cuscutae is xeothermic；Witloof property is raw, and function life is wet
Raw cold, dysregulation bile matter reduces irascibility, and the heat of clearing stomach dispels jaundice, and diuresis detumescence cures mainly xeothermic property or bile matter
Property disease；The sub- property of witloof is dry cold, opens liver resistance, and heat clearing and inflammation relieving eliminates jaundice, and diuresis detumescence cures mainly liver obstruction, wet
Hot hepatitis, icterepatitis, anasarca etc.；Rose micro-pungent, perfume (or spice), cure mainly bile matter disease.The complete raw humidogene heat in side,
Anti-inflammatory detumescence, cures mainly dry cold or black biliar disease, and modern clinic is mainly used in hepatitis, cholecystitis, urinary tract infections etc..Tool
There are detumescence well, analgesic, diuresis.
Article《Inflammation disappear enlightening Na youngster's syrup Pharmacodynamics research》The o. 11th of in November, 2011 page 74, National medicine
Inflammation is disclosed in magazine and disappears enlightening Na youngster syrup to jaundice with damp-heat pathogen can be treated, though jaundice with damp-heat pathogen and cholestatic jaundice are in clinical condition
There is certain relevance on shape, but the pathogenesis of the two are different, belong to different indications, therefore, studying and treating
During should treat with a certain discrimination.And inflammation disappear described in enlightening Na youngster's syrup specification be used for various hepatitis, cholecystitis, urinary tract infections, its
Middle cholestatic jaundice and hepatitis belong to different concepts, therefore, should be treated with a certain discrimination in research and therapeutic process.Inventor grinds
Studied carefully the cholestatic Icterus treatment effect of a large amount of hepatics, repeatedly research compare in it was unexpectedly observed that inflammation disappears Di Na
Youngster's syrup be can be also used for treating cholestatic jaundice, and especially, the bilirubin caused to cholestatic jaundice is raised, and has suppression
Make and use, also, the inflammation disappears, and enlightening Na youngster's pharmaceutical composition is of a tightly knit structure, compatibility is precise and appropriate, and burden of liver is small, and toxic and side effect is small.
Thus, according to an aspect of the present invention, disappear enlightening Na youngster's pharmaceutical composition the invention provides a kind of inflammation.According to the present invention
Embodiment, the inflammation enlightening Na youngster's pharmaceutical composition that disappears includes：Cichory root, witloof, rose, rheum officinale, oral shui solution, ox
Tongue grass, Semen Cuscutae, the inflammation disappear enlightening Na youngster pharmaceutical composition for treating cholestatic jaundice.
Inventor has surprisingly found that, the inflammation of the invention enlightening Na youngster pharmaceutical composition that disappears has to cholestatic jaundice and preferably controls curative effect
Really, especially, the bilirubin that causes to cholestatic jaundice is raised, and has an inhibitory action, also, the inflammation disappears enlightening Na youngster's medicine group
The of a tightly knit structure of compound, compatibility are precise and appropriate, and burden of liver is small, and toxic and side effect is small.
Enlightening Na youngster's pharmaceutical composition in addition, inflammation according to the above embodiment of the present invention disappears, can also have following additional technology special
Levy：
Embodiments in accordance with the present invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root 100-200 weight portions, witloof
Sub- 50-100 weight portions, rose 50-100 weight portions, rheum officinale 50-100 weight portions, oral shui solution 20-80 weight portions, cow tongue
Careless 20-80 weight portions, Semen Cuscutae 5-30 weight portions.
Some preferred embodiments of the invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120,
60 weight portions of witloof, the weight portion of rose 60, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight of oxtongue 30
Part, the weight portion of Semen Cuscutae 9.Thus, the synergy of each component is more obvious, to the therapeutic effect of cholestatic jaundice more
It is good.
Embodiments in accordance with the present invention, the inflammation of the UD quality that enlightening Na youngster's pharmaceutical composition contains aesculetin that disappears is
40-400μg.Thus, the inflammation of UD disappears in enlightening Na youngster's pharmaceutical composition, the Qin of the effective therapeutic component containing sufficient dosage
Skin B prime, so that, it is ensured that the inflammation enlightening Na youngster pharmaceutical composition that disappears has good therapeutic effect to cholestatic jaundice.
Embodiments in accordance with the present invention, the inflammation disappear enlightening Na youngster's pharmaceutical composition formulation be selected from parenteral solution, tablet, granule,
One of syrup, capsule, oral liquid, aerosol and spray.Thus, it is easy to according to administration object difference, using difference
Formulation.
Embodiments in accordance with the present invention, the inflammation enlightening Na youngster pharmaceutical composition that disappears is provided in the form of inflammation disappears enlightening Na youngster's syrup.Thus,
Using existing Chinese patent drug, you can treatment cholestatic jaundice, also, medicine good effect, toxic and side effect is small.
According to another aspect of the invention, enlightening Na youngster's pharmaceutical composition is disappeared in medicine is prepared present invention also offers foregoing inflammation
Purposes.Embodiments in accordance with the present invention, the medicine is used to treat cholestatic jaundice, wherein, the inflammation disappears enlightening Na youngster's medicine
Compositions are included：Cichory root, witloof, rose, rheum officinale, oral shui solution, oxtongue, Semen Cuscutae.
Embodiments in accordance with the present invention, medicine of the invention can apply to the treatment of cholestatic jaundice, and with preferable
Therapeutic effect, especially, the bilirubin that causes to cholestatic jaundice is raised, and has an inhibitory action, also, the medicine structure
Rigorous, compatibility is precise and appropriate, and burden of liver is small, and toxic and side effect is small.
Embodiments in accordance with the present invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root 100-200 weight portions, witloof
Sub- 50-100 weight portions, rose 50-100 weight portions, rheum officinale 50-100 weight portions, oral shui solution 20-80 weight portions, cow tongue
Careless 20-80 weight portions, Semen Cuscutae 5-30 weight portions.
Some preferred embodiments of the invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120,
60 weight portions of witloof, the weight portion of rose 60, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight portion of oxtongue 30, Tu
Sub 9 weight portion of silk.Thus, each group distribution ratio is proper, acts synergistically more obvious, to the therapeutic effect of cholestatic jaundice
More preferably.
Embodiments in accordance with the present invention, the quality that the medicine of UD contains aesculetin is 40-400 μ g.Thus, it is single
In the medicine of position dosage, the aesculetin of the effective therapeutic component containing sufficient dosage, so that, it is ensured that medicine is to cholestatic
Jaundice has good therapeutic effect.
Embodiments in accordance with the present invention, the formulation of the medicine is selected from parenteral solution, tablet, granule, syrup, capsule, mouth
Take one of liquid, aerosol and spray.Thus, it is easy to according to administration object difference, using different formulations.
Embodiments in accordance with the present invention, the medicine is provided in the form of inflammation disappears enlightening Na youngster's syrup.Thus, using it is existing it is middle into
Medicine, you can treatment cholestatic jaundice, also, medicine good effect, toxic and side effect is small.
Additional aspect of the invention and advantage will be set forth in part in the description, and partly will from the following description become bright
It is aobvious, or recognized by practice of the invention.
Brief description of the drawings
Of the invention above-mentioned and/or additional aspect and advantage be will be apparent from description of the accompanying drawings below to embodiment is combined and
It is readily appreciated that, wherein：
During Fig. 1 shows that cholestatic jaundice according to an embodiment of the invention is tested, each experimental group hepatic tissue section HE
Dyeing picture, wherein, A is blank control group, and B is model group, and C disappears enlightening Na youngster's syrup 5.5ml/kg, D for model+inflammation
For model+inflammation disappears enlightening Na youngster's syrup 11ml/kg, E for model+inflammation disappears enlightening Na youngster's syrup 22ml/kg, F is that model+liver is felt well particle
Group, G is model+Compound Liver-benepitino Remedy group.
Specific embodiment
Embodiments of the invention are described below in detail.The embodiments described below is exemplary, is only used for explaining the present invention, and
It is not considered as limiting the invention.
According to an aspect of the present invention, disappear enlightening Na youngster's pharmaceutical composition, implementation of the invention the invention provides a kind of inflammation
Example, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root, witloof, rose, rheum officinale, oral shui solution, oxtongue, Tu
Silk, also, the inflammation disappears enlightening Na youngster pharmaceutical composition for treating cholestatic jaundice.
Inventor has surprisingly found that, the inflammation of the invention enlightening Na youngster pharmaceutical composition that disappears has to cholestatic jaundice and preferably controls curative effect
Really, especially, the bilirubin that causes to cholestatic jaundice is raised, and has an inhibitory action, also, the inflammation disappears enlightening Na youngster's medicine group
The of a tightly knit structure of compound, compatibility are precise and appropriate, and burden of liver is small, and toxic and side effect is small.
According to a particular embodiment of the invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root 100-200 weight portions,
The sub- 50-100 weight portions of witloof, rose 50-100 weight portions, rheum officinale 50-100 weight portions, oral shui solution 20-80 weight portions,
Oxtongue 20-80 weight portions, Semen Cuscutae 5-30 weight portions.Thus, in the range of the weight proportion, this Six-element medicine proportioning is proper,
Synergy is obvious, effectively the therapeutic effect of enhancing medicine, and especially, the therapeutic effect to cholestatic jaundice is good.
According to a preferred embodiment of the invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120, witloof
Sub 60 weight portions, the weight portion of rose 60, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight portion of oxtongue 30,
The weight portion of Semen Cuscutae 9.Thus, under the weight proportion scope, act on more significantly, curative effect is controlled to cholestatic jaundice
Fruit is more preferably.
Embodiments in accordance with the present invention, the inflammation of UD disappears quality that enlightening Na youngster's pharmaceutical composition contains aesculetin by special
Limitation, have therapeutic action to cholestatic jaundice.Some preferred embodiments of the invention, UD should
The inflammation quality that enlightening Na youngster's pharmaceutical composition contains aesculetin that disappears is 40-400 μ g.Thus, the inflammation of UD disappears enlightening Na youngster's medicine
In composition, the effective therapeutic component aesculetin containing sufficient dosage, the drug dose for reaching treatment cholestatic jaundice will
Ask, so that, it is ensured that the inflammation enlightening Na youngster pharmaceutical composition that disappears has good therapeutic effect to cholestatic jaundice.
Term used herein " UD " refers to the drug dose of single administration, that is, apply once inflammation of the invention and disappear Di Na
During youngster's pharmaceutical composition, the inflammation disappears the dosage of enlightening Na youngster's pharmaceutical composition, the formulation of the enlightening Na youngster's pharmaceutical composition that can be disappeared according to inflammation
It is determined that the organization of corresponding UD.
Some embodiments of the invention, the inflammation disappear enlightening Na youngster's pharmaceutical composition formulation be selected from parenteral solution, tablet, granule,
One of syrup, capsule, oral liquid, aerosol and spray.
Some embodiments of the invention, the inflammation disappears what enlightening Na youngster pharmaceutical composition was provided in the form of inflammation disappears enlightening Na youngster's syrup.
Thus, disappeared enlightening Na youngster's syrup using existing commercially available dimension medicine inflammation, you can treatment cholestatic jaundice, meanwhile, relative to existing
Some treatment cholestatic jaundice medicine, the therapeutic effect of the medicine is good, especially, cholestatic jaundice is caused
Bilirubin is raised, and has inhibitory action, also, the toxic and side effect of the medicine is small.
According to another aspect of the invention, enlightening Na youngster's pharmaceutical composition is disappeared in medicine is prepared present invention also offers foregoing inflammation
Purposes.Embodiments in accordance with the present invention, the medicine is used to treat cholestatic jaundice, wherein, the inflammation disappears enlightening Na youngster's medicine group
Compound is included：Cichory root, witloof, rose, rheum officinale, oral shui solution, oxtongue, Semen Cuscutae.
Embodiments in accordance with the present invention, medicine of the invention can apply to the treatment of cholestatic jaundice, and with preferable
Therapeutic effect, especially, the bilirubin that causes to cholestatic jaundice is raised, and has an inhibitory action, also, the medicine structure
Rigorous, compatibility is precise and appropriate, and burden of liver is small, and toxic and side effect is small.
According to a particular embodiment of the invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root 100-200 weight portions,
The sub- 50-100 weight portions of witloof, rose 50-100 weight portions, rheum officinale 50-100 weight portions, oral shui solution 20-80 weight portions,
Oxtongue 20-80 weight portions, Semen Cuscutae 5-30 weight portions.Thus, in the range of the weight proportion, this Six-element medicine proportioning is proper,
Synergy is obvious, effectively the therapeutic effect of enhancing medicine, and especially, the therapeutic effect to cholestatic jaundice is good.According to this
The preferred embodiment of invention, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120, witloof 60 weight of son
Part, the weight portion of rose 60, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight portion of oxtongue 30, the weight of Semen Cuscutae 9
Amount part.Thus, under the weight proportion scope, act on more significantly, to the therapeutic effect of cholestatic jaundice more preferably.
Some embodiments of the invention, the inflammation of the UD quality that enlightening Na youngster's pharmaceutical composition contains aesculetin that disappears is not received
Special limitation, has therapeutic action to cholestatic jaundice.Some preferred embodiments of the invention, UD
The inflammation quality that enlightening Na youngster's pharmaceutical composition contains aesculetin that disappears be 40-400 μ g.Thus, the inflammation of UD disappears enlightening Na youngster
In pharmaceutical composition, the effective therapeutic component aesculetin containing sufficient dosage reaches the medicine agent for the treatment of cholestatic jaundice
Amount requires, so that, it is ensured that the inflammation enlightening Na youngster pharmaceutical composition that disappears has good therapeutic effect to cholestatic jaundice.
Some embodiments of the invention, the formulation of the medicine be selected from parenteral solution, tablet, granule, syrup, capsule,
One of oral liquid, aerosol and spray.Thus, it is easy to according to administration object difference, using different formulations.For example,
For the ease of administration, tablet, granule, syrup, capsule and oral liquid can be used, and it is possible to according to the suction of medicine
The release demand of position and medicine is received, the formulation to medicine is adjusted, so as to improve the bioavilability of medicine, extend medicine
Release time.For the person of being in a bad way, parenteral solution can be used, and then realize heavy dose of administration requirements, and, it is to avoid
Influence of the gastrointestinal circulation to effective ingredient.
According to a particular embodiment of the invention, the inflammation enlightening Na youngster pharmaceutical composition that disappears is provided in the form of inflammation disappears enlightening Na youngster's syrup.By
This, is disappeared enlightening Na youngster's syrup, you can treatment cholestatic jaundice using existing commercially available dimension medicine inflammation, meanwhile, relative to existing
The medicine of some treatment cholestatic jaundice, the therapeutic effect of the medicine is good, especially, the courage caused to cholestatic jaundice
Red pigment is raised, and has significant inhibitory action, also, the toxic and side effect of the medicine is small.
Below with reference to specific embodiment, the present invention will be described, it is necessary to explanation, these embodiments are merely illustrative,
And be not considered as limiting the invention.
Embodiment 1
By disposable gavage isothiocyanic acid -1- naphthalene esters, set up SD rat biles and smoulder type Jaundice Model, after poisoning 72h, see
Examine each index such as rat blood, liver, pathological section, evaluation test medicine to the pharmacodynamic action of cholestatic jaundice and with
Its in similar drug feature or odds ratio compared with.
1st, experiment material
Animal：SD (Sprague-Dawley) rat 80, SPF (specific pathogen free) level, 220~250g of body weight,
Male and female half and half, are provided, animal credit number by Hubei Province Animal Experimental Study center：SCXK (Hubei Province) 2008-0005.
Instrument：Centrifuge, 96 orifice plates, 1.5ml Eppendorf pipes, 5ml Eppendorf pipes, 10ml Eppendorf pipes,
Weigh balance, operating theater instruments, ELIASA, light microscopic.
Reagent and medicine：Isothiocyanic acid -1- naphthalene esters, are provided, Lot by Beijing lark prestige Science and Technology Ltd.：LSA0N13；First
Aldehyde, is provided by Chemical Reagent Co., Ltd., Sinopharm Group；Compound Liver-benepitino Remedy, is provided by China Resources Double-Crane Pharmaceutical Co., Ltd.,
Lot number：1405102；Liver is felt well particle, is provided by Baoding Tianhao Pharmaceutical Co., Ltd., lot number：140603.
Kit：ALT kits, AST kits, ALP kits, TBIL kits, γ-GT kits, by force
Han Kerui Bioisystech Co., Ltd provides.
Method for preparation of drug：
Inflammation disappears enlightening Na youngster's syrup：
22ml/kg：924ml inflammation is taken to disappear enlightening Na youngster's syrup, 4 DEG C of Refrigerator stores；
11ml/kg：462ml inflammation is taken to disappear enlightening Na youngster's syrup, 4 DEG C of Refrigerator stores；
5.5ml/kg：Take 231ml inflammation to disappear enlightening Na youngster's syrup, plus 189ml distilled water, mix, 4 DEG C of Refrigerator stores；
Comparison medicine Compound Liver-benepitino Remedy：
60 Fufang Yiganling tablets, grind into powder, plus 420ml distilled water are taken, is mixed, 4 DEG C of Refrigerator stores.
Comparison medicine liver is felt well particle：
The refreshing particle of 46.2g livers, plus 420ml distilled water are taken, is mixed, 4 DEG C of Refrigerator stores.
Isothiocyanic acid -1- naphthalene esters：
10mg/ml(100mg/kg)：3.0 isothiocyanic acid -1- naphthalene esters, plus 300ml salad oils are taken, is mixed, 4 DEG C of Refrigerator stores.
2nd, experimental technique
SD rats 80 are only randomly divided into 8 groups, and daily gavage (ig) gives by reagent, continuous 10 days, is administered in the 7th day
1h afterwards, normal group gavage equivalent salad oil, the equal gavage isothiocyanic acid -1- naphthalenes ester 100mg/kg (1ml/100g) of remaining each group, in
After malicious 72h, rat is plucked eyeball and takes blood, separates serum, with spectrophotometric measure Biochemical Indices In Serum glutamic-pyruvic transaminase (ALT),
Glutamic-oxalacetic transaminease (AST), total bilirubin (TBIL), alkaline phosphatase (ALP), glutamyl transpeptidase (γ-GT).
Rat is put to death, liver is cut at same position, 4% formaldehyde is fixed, tissue disease is made in routine paraffin wax section, HE dyeing under light microscopic
Neo-Confucianism observation.
3rd, statistics analytic method
Statistical procedures：All data withRepresent, processed with SPSS19.0 statistical softwares, measurement data is multigroup
Between compare and use variance analysis, compare two-by-two between each group using T inspections.P<0.05 is that difference is statistically significant.
4th, experimental result
(1) influence and inflammation of the cholestatic jaundice to rat body weight and the death rate disappears the intervention effect of enlightening Na youngster's syrup
The daily gavage of rat (ig) is administered once, continuous 10 days, and the disposable gavages of 1h give 100mg/kg after being administered in the 7th day
Isothiocyanic acid -1- naphthalene esters, set up cholestatic Jaundice Model.In the 11st day before processing observation result, increase with normal group body weight
Long value is compared, and model group rats body weight is remarkably decreased (P<0.01)；Each by reagent has increases becoming for model mouse weight gain value
Gesture, inflammation enlightening Na youngster syrup (22ml/kg), inflammation enlightening Na youngster syrup (11ml/kg) group that disappears that disappears can be significantly inhibited under rat body weight
Drop trend, points out that rat functions of intestines and stomach may can be improved, and compared with control group, substantially, each group by reagent is to rats death for curative effect
Rate the results are shown in Table 1 without influence.
Influence and inflammation of the cholestatic jaundice of table 1. to rat body weight and the death rate disappear the intervention effect (χ ± SD) of enlightening Na youngster's syrup
Note：Cholestatic Jaundice Model mouse gives isothiocyanic acid -1- naphthalene esters 100mg/kg for the 7th day disposable ig of administration；
The * * P compared with normal group<0.01；
Compared with model group##P<0.01；
N is size of animal.
(2) influence and inflammation of the cholestatic jaundice to rat liver index disappears the intervention effect of enlightening Na youngster's syrup
Give visible after ig isothiocyanic acid -1- naphthalene ester 100mg/kg 72h, liver is presented enlargement trend, and liver index significantly increases
(P<0.05)；Inflammation disappear enlightening Na youngster syrup (11ml/kg), the inflammation of enlightening Na youngster syrup (22ml/kg), inflammation that disappear disappears enlightening Na youngster's syrup
(5.5ml/kg) group has improvement trend to hepatomegaly caused by ChJ, the results are shown in Table 2.
Influence and inflammation of the cholestatic jaundice of table 2. to rat liver index disappear the intervention effect (χ ± SD) of enlightening Na youngster's syrup
Note：Cholestatic Jaundice Model mouse gives isothiocyanic acid -1- naphthalene esters 100mg/kg for the 7th day disposable ig of administration；
The * P compared with normal group<0.05；
Compared with model group#P<0.05；
N is size of animal.
(3) influence and inflammation of the cholestatic jaundice to rat blood serum ALT, AST activity disappears the intervention effect of enlightening Na youngster's syrup
Successive administration 10 days, the 7th day ig gives isothiocyanic acid -1- naphthalene esters 100mg/kg, visible after 72h, rat blood serum ALT,
AST activity is significantly raised, wherein, inflammation enlightening Na youngster syrup (11ml/kg), inflammation enlightening Na youngster syrup (5.5ml/kg) that disappears that disappears it is tested
Medicine can be with the ALT activity in conspicuousness reduction rat blood serum；The results are shown in Table 3.
Influence and inflammation of the cholestatic jaundice of table 3. to rat blood serum ALT, AST activity disappear the intervention effect (χ ± SD) of enlightening Na youngster's syrup
Note：Cholestatic Jaundice Model mouse gives isothiocyanic acid -1- naphthalene esters 100mg/kg for the 7th day disposable ig of administration；
The * * P compared with normal group<0.01；
Compared with model group##P<0.01；
N is size of animal.
(4) influence and inflammation of the cholestatic jaundice to rat blood serum AKP, γ-GT vigor and TBIL contents disappear enlightening Na youngster sugar
The intervention effect of slurry
Successive administration 10 days, the 7th day ig gives isothiocyanic acid -1- naphthalene esters 100mg/kg, visible after 72h, in rat blood serum
AKP, γ-GT vigor and TBIL contents significantly raise (P<0.01), wherein, feel well particle (1100mg/kg), inflammation of liver disappears
ALP is raised in the serum that enlightening Na youngster syrup (5.5ml/kg) causes to cholestatic jaundice has conspicuousness reduction to act on；Inflammation disappears
Enlightening Na youngster syrup (11ml/kg), inflammation disappear enlightening Na youngster syrup (5.5ml/kg), have significantly to γ-GT activity in model mouse serum
Property reduction effect；Inflammation disappear enlightening Na youngster syrup (11ml/kg) group have to TBIL contents in serum conspicuousness reduction act on, as a result see
Table 4.
Influence and inflammation of the cholestatic jaundice of table 4. to rat blood serum AKP, γ-GT vigor and TBIL contents disappear the intervention of enlightening Na youngster's syrup
Effect (χ ± SD)
Note：Cholestatic Jaundice Model mouse gives isothiocyanic acid -1- naphthalene esters 100mg/kg for the 7th day disposable ig of administration；
The * * P compared with normal group<0.01；
Compared with model group#P<0.05,##P<0.01；
N is size of animal.
(5) hepatic tissue section HE coloration results
As shown in figure 1, the visible inflammatory cell infiltration of model group liver, degeneration of liver cells, necrosis, bile duct epithelial cell structure are broken
It is bad；Inflammation enlightening Na youngster syrup (11ml/kg) that disappears is cut into slices visible preferable improvement result.
5th, conclusion
The enlightening that disappears Na youngster syrup can improve the influence that cholestatic jaundice is reduced to rat body weight, reduce the rat model serum
ALT, ALP, γ-GT, TBIL levels and liver index.There is significantly therapeutic action to cholestatic jaundice.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specific example ",
Or the description of " some examples " etc. means to combine specific features, structure, material or feature bag that the embodiment or example are described
It is contained at least one embodiment of the invention or example.In this manual, the schematic representation to above-mentioned term not necessarily refers to
Be identical embodiment or example.And, the specific features of description, structure, material or feature can be at any one
Or combined in an appropriate manner in multiple embodiments or example.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：This is not being departed from
Can these embodiments be carried out with various changes, modification, replacement and modification in the case of the principle and objective of invention, it is of the invention
Scope is limited by claim and its equivalent.
Claims (10)
1. a kind of inflammation disappears enlightening Na youngster's pharmaceutical composition, and the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root, witloof son,
Rose, rheum officinale, oral shui solution, oxtongue, Semen Cuscutae, it is characterised in that the inflammation disappears enlightening Na youngster pharmaceutical composition for controlling
Treat cholestatic jaundice.
2. inflammation according to claim 1 disappears enlightening Na youngster's pharmaceutical composition, it is characterised in that the inflammation disappears enlightening Na youngster's medicine
Composition is included：The sub- 50-100 weight portions of cichory root 100-200 weight portions, witloof, rose 50-100 weight portions, rheum officinale
50-100 weight portions, oral shui solution 20-80 weight portions, oxtongue 20-80 weight portions, Semen Cuscutae 5-30 weight portions,
Preferably, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120,60 weight portions of witloof, rose
It is rare to spend 60 weight portions, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight portion of oxtongue 30, the weight portion of Semen Cuscutae 9.
3. inflammation according to claim 1 disappears enlightening Na youngster's pharmaceutical composition, it is characterised in that the inflammation of UD disappears
The quality that enlightening Na youngster's pharmaceutical composition contains aesculetin is 40-400 μ g.
4. inflammation according to claim 1 disappears enlightening Na youngster's pharmaceutical composition, it is characterised in that the inflammation disappears enlightening Na youngster's medicine
The formulation of composition be selected from parenteral solution, tablet, granule, syrup, capsule, oral liquid, aerosol and spray it
One.
5. inflammation according to claim 1 disappears enlightening Na youngster's pharmaceutical composition, it is characterised in that the inflammation disappears enlightening Na youngster's medicine
Composition is provided in the form of inflammation disappears enlightening Na youngster's syrup.
6. scorching purposes of the enlightening Na youngster's pharmaceutical composition in medicine is prepared that disappear described in any one of claim 1-5, the medicine is used
In treatment cholestatic jaundice, wherein, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root, witloof, rose,
Rheum officinale, oral shui solution, oxtongue, Semen Cuscutae.
7. purposes according to claim 6, it is characterised in that the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：Cichory root
The sub- 50-100 weight portions of 100-200 weight portions, witloof, rose 50-100 weight portions, rheum officinale 50-100 weight portions, water lily
Flower 20-80 weight portions, oxtongue 20-80 weight portions, Semen Cuscutae 5-30 weight portions,
Preferably, the inflammation enlightening Na youngster's pharmaceutical composition that disappears is included：The weight portion of cichory root 120,60 weight portions of witloof, rose
It is rare to spend 60 weight portions, the weight portion of rheum officinale 40, the weight portion of oral shui solution 30, the weight portion of oxtongue 30, the weight portion of Semen Cuscutae 9.
8. purposes according to claim 6, it is characterised in that the medicine of UD contains the matter of aesculetin
It is 40-400 μ g to measure.
9. purposes according to claim 6, it is characterised in that the formulation of the medicine be selected from parenteral solution, tablet,
One of granule, syrup, capsule, oral liquid, aerosol and spray.
10. purposes according to claim 6, it is characterised in that the inflammation enlightening Na youngster pharmaceutical composition that disappears is disappeared Di Na with inflammation
The form of youngster's syrup is provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510825237.8A CN106728126A (en) | 2015-11-24 | 2015-11-24 | Inflammation disappear enlightening Na youngster pharmaceutical composition prepare treatment cholestatic jaundice medicine in application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510825237.8A CN106728126A (en) | 2015-11-24 | 2015-11-24 | Inflammation disappear enlightening Na youngster pharmaceutical composition prepare treatment cholestatic jaundice medicine in application |
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| Publication Number | Publication Date |
|---|---|
| CN106728126A true CN106728126A (en) | 2017-05-31 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510825237.8A Pending CN106728126A (en) | 2015-11-24 | 2015-11-24 | Inflammation disappear enlightening Na youngster pharmaceutical composition prepare treatment cholestatic jaundice medicine in application |
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| Country | Link |
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| CN (1) | CN106728126A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585380A (en) * | 2023-05-19 | 2023-08-15 | 新奇康药业股份有限公司 | Vinegar mixture for treating epilepsy and preparation method thereof |
-
2015
- 2015-11-24 CN CN201510825237.8A patent/CN106728126A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 刘吉祥等，: "《常用药品应用与选购》", 31 December 2006, 上海三联书店 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585380A (en) * | 2023-05-19 | 2023-08-15 | 新奇康药业股份有限公司 | Vinegar mixture for treating epilepsy and preparation method thereof |
| CN116585380B (en) * | 2023-05-19 | 2023-12-05 | 新奇康药业股份有限公司 | Composition for treating epilepsy and preparation method thereof |
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Application publication date: 20170531 |