CN106728013A - A kind of Chinese medicine composition and preparation method and application for treating gall stone - Google Patents

A kind of Chinese medicine composition and preparation method and application for treating gall stone Download PDF

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Publication number
CN106728013A
CN106728013A CN201611031686.6A CN201611031686A CN106728013A CN 106728013 A CN106728013 A CN 106728013A CN 201611031686 A CN201611031686 A CN 201611031686A CN 106728013 A CN106728013 A CN 106728013A
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China
Prior art keywords
parts
chinese medicine
fixed
gall stone
casing
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CN201611031686.6A
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Chinese (zh)
Inventor
王菊明
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Suzhou Fengling Pharmaceutical Co Ltd
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Suzhou Fengling Pharmaceutical Co Ltd
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Priority to CN201611031686.6A priority Critical patent/CN106728013A/en
Publication of CN106728013A publication Critical patent/CN106728013A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a kind of Chinese medicine composition for treating gall stone, extracted by the bulk drug of following parts by weight and prepared:20 30 parts of Common Leafflower Herb, 10 20 parts of coriaceous knotweed rhizome, 15 25 parts of sharp knife Herba Sonchi Oleracei, 18 22 parts of fine hair Ivy Tree Bark, 10 20 parts of great Ye Lepisorus thunbergianus (Kaulf.) Chings, 8 16 parts of the red sage root, 37 parts of Radix Glycyrrhizae, energy heat clearing and inflammation relieving, regulating qi-flowing for relieving pain, treatment gall stone, and disclose preparation method and purposes.

Description

A kind of Chinese medicine composition and preparation method and application for treating gall stone
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation side for treating gall stone Method and application.
Background technology
The origin cause of formation of gall stone is extremely complex, and some are not modifiable factors, for example:Age, women, the kind for gradually increasing Race, gene and family history;Some are acquired dispositions, can be partly reverse, for example:Pregnant, fat, low fiber, calorie high Dietary structure, long-time fasting, some drugses such as ceftriaxone, lipid-lowering medicine, oral contraceptive, fast weight lose, be metabolized it is comprehensive Simulator sickness, special disease etc..At present, the conventional therapy for gall stone is still based on operation but very big to human injury, Chinese medicine The features such as there is small toxicity, treat both principal and secondary aspect of disease with ethnic drug, therefore find the medicine for the treatment of gall stone with Chinese herbal medicine as primary raw material Thing has caused the close attention of numerous scientific and technical personnel, and Chinese medicine gall stone has also turned into a current important topic.Mesh Preceding in the market lacks real effective patent medicine.
The content of the invention
Goal of the invention:In order to solve the above problems, it is an object of the invention to provide it is a kind of for treating gall stone in Drug composition and preparation method and application.
Technical scheme:The purpose of the present invention is realized by following scheme:
A kind of Chinese medicine composition for treating gall stone, it is extracted by the bulk drug of following parts by weight and prepared:Under leaf Pearl 20-30 parts, coriaceous knotweed rhizome 10-20 parts, 15-25 parts of sharp knife Herba Sonchi Oleracei, 18-22 parts of fine hair Ivy Tree Bark, great Ye Lepisorus thunbergianus (Kaulf.) Chings 10-20 Part, red sage root 8-16 parts, Radix Glycyrrhizae 3-7 parts.
The Chinese medicine composition of the treatment gall stone, it is extracted by the bulk drug of following parts by weight and prepared:Under leaf 25 parts of pearl, 15 parts of coriaceous knotweed rhizome, 20 parts of sharp knife Herba Sonchi Oleracei, 20 parts of fine hair Ivy Tree Bark, 15 parts of great Ye Lepisorus thunbergianus (Kaulf.) Chings, 12 parts of the red sage root, Radix Glycyrrhizae 5 Part.
The Chinese medicine composition of the treatment gall stone, preparation method comprises the following steps:Take Common Leafflower Herb, coriaceous knotweed rhizome, sharp knife Herba Sonchi Oleracei, fine hair Ivy Tree Bark, great Ye Lepisorus thunbergianus (Kaulf.) Chings, the red sage root, licorice medicinal materials merge, and crush, and are put into Chinese medicine pre-treatment machine processing, locate Medicinal material is added water to cook twice after reason, and amount of water is 10 times of amounts of medicinal material weight, decocts 2h, and collecting decoction is concentrated into 65 DEG C of phases It is 1.10 to density, plus ethanol makes the percent by volume of alcohol content up to 65%, stirring stands, and filtering, filtrate decompression is concentrated into 65 DEG C when relative density is 1.20 and reclaims ethanol, concentrate is put into medicinal extract drying machine drying, and addition auxiliary material is made capsule, piece Agent, granule.
The Chinese medicine composition of the treatment gall stone, Chinese medicine pre-treatment machine includes device case in preparation method, in institute The top surface for stating device case has feed hopper, has Chinese medicine derivation passage in the sidewall bottom of described device housing, in described device shell Inclination stock guide is provided with vivo, the top of the inclination stock guide is connected on the inwall of device case and is in by rotary shaft The underface of feed hopper, bottom and the Chinese medicine of the inclination stock guide are derived passage and are connected, it is characterised in that:In described device Vibrating seat is fixed with the bottom wall of housing, electric rotating machine is fixed with the vibrating seat, on the main shaft of the electric rotating machine Wheel disc is provided with, vibrating arm is provided between the card of the wheel disc and the bottom of inclination stock guide, the bottom of the vibrating arm leads to Cross bearing pin be connected in the card of wheel disc and the vibrating arm top be fixed on incline stock guide bottom bottom surface, in the dress The top side wall for putting housing is provided with strip through-hole, and the strip through-hole is derived passage and is arranged on same side with Chinese medicine, in institute State U-shaped impurity fixed on the outer wall of device case and collect body, central shaft is provided with the strip through-hole, in described device shell Have the motor being connected by belt transmission with the central shaft on body, be additionally provided with magnetic annulus, the magnetic annulus it is interior Wall is fixed on center shaft by muscle bar, the edge of the magnetic annulus be connected to incline on stock guide and magnetic annulus outside The side top that body is collected in edge with U-shaped impurity compresses and contacts.
The Chinese medicine composition of the treatment gall stone, U-shaped impurity is collected described in Chinese medicine pre-treatment machine in preparation method The top of body is provided with inclination scraper plate, and the inclination scraper plate is connected to the surface of magnetic annulus.
The Chinese medicine composition of the treatment gall stone, inclining stock guide described in Chinese medicine pre-treatment machine in preparation method is Plastic material plate body, the width of the inclination scraper plate is identical with the width of magnetic annulus.
The Chinese medicine composition of the treatment gall stone, medicinal extract dryer includes casing in preparation method, is arranged on the case Internal carrying web plate, hot wind inlet is provided with the bottom wall of the casing, has chamber door at the top of the casing, and its feature exists In:There is vertical guide chute on the inwall of the casing, slotted eye is provided with the casing upper side wall, the slotted eye connects case The inner chamber of body and outside, the middle part for carrying web plate are connected in casing by rotary shaft, and the slotted eye is vertically led with described It is symmetrical arranged centered on rotary shaft to chute, lifting slider is fixed with one end of the carrying web plate, in the bearer network The other end of plate is fixed with and compresses pole, and the lifting slider is arranged in vertical guide chute and described compresses pole through institute State slotted eye and stretch out casing, stress extension spring is provided between the bottom wall of the lifting slider and the vertical guide chute, it is described to receive The bottom of power extension spring is fixed on the bottom wall of vertical guide chute and the top of stress extension spring is fixed on lifting slider, described Motor is fixed with the outer wall of casing, eccentric wheel is fixed with the main shaft of the motor, in the eccentric wheel It is fixed with projection wheel side and compresses projection, the eccentric wheel rotates under the drive of motor and makes to compress bump contact and support It is connected on and compresses on pole.
The Chinese medicine composition of the treatment gall stone, the edge for carrying web plate in preparation method described in medicinal extract dryer sets The base for having vertical backstop, the vertical backstop is weldingly fixed on the edge for carrying web plate.
The Chinese medicine composition of the treatment gall stone, projection is compressed for arc in preparation method described in medicinal extract dryer Block, and anti-skidding burr is provided with the surface for compressing projection, the anti-skidding burr is arranged on and compressed on the contact surface of pole, The height of the anti-skidding burr is 5-10mm.
The Chinese medicine composition of the treatment gall stone is preparing answering in suppressing Mouse cartilage ATDC5 cell proliferations With.
Raw material Common Leafflower Herb in the present invention, scientific name:Phyllanthus urinaria L.), annual herb plant, number high It is very little to be permitted to chi.Stem band aubergine, there is vertical rib.Leaf alternate, makees multiple tiles arrangement, forms two rows, very like winglike compound leaf, blade square circle Shape, long two, three points, Quan Lv, tip is sharp or blunt, basal circular, several without petiole.Summer and autumn along white little Hua is opened below cauline leaf, without flower Handle.Oblate fruitlet is tied after spending, shape such as globule is arranged in below false compound leaf.Reducing fever and causing diuresis, improving eyesight, disperse accumulations.For ephritis water It is swollen, urinary infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition due to digestive disturbances or intestinalparasites, eye keratitis, icteric hepatitis;External application is controlled green bamboo snake and is bitten.
Coriaceous knotweed rhizome, Latin literary fame:Hemsleya sphaerocarpa Kuang et A.M.Lu, are belonging to Curcurbitaceae snow Courage belongs to, perennial herb, high up to 1 meter.A kind of herbaceous species plant on the ground such as Yunnan, Guizhou is distributed in, sea is born in more Pull out under 800-1400 meters of broad-leaf forest side or mountain valley sparse woods.Heat-clearing, removing toxic substances, convergence, myogenic.Dysentery is controlled, is suffered from diarrhoea, carbuncle swells, hemorrhoid, Burn.The present invention is with all herbal medicine.
Sharp knife Herba Sonchi Oleracei is that composite family Ixeris Cass plant pitches branch oxtongue Picris divaricata Vaniot, with herb It is used as medicine.Spring and summer Qiu Kecai, cleans, and using fresh herb or dries.It is clearing heat and detoxicating.For cold, fever;Venomous snake bite is controlled in external application.
Fine hair Ivy Tree Bark is Araliaceae Schettlera delavayi Agalma delavayi (Franch.) Hutch., with root or Stem is used as medicine.Whole year can be adopted, and section is dried.Dispelling, collateral-activating, filling liver kidney, strengthening the bones and muscles.For fracturing, bruise, lumbar muscle strain, rheumatism Arthralgia, lumbago due to the kidney deficiency, traumatic injury convalescence.
Great Ye Lepisorus thunbergianus (Kaulf.) Chings are Polypodiaceae subfam. Microsoroideae Cyclosorus plant south of the River star fern Microsorium fortune (Moore) Ching, is used as medicine with herb and root-like stock.The four seasons can adopt, and clean, and using fresh herb or dry.Clearing heat and promoting diuresis, cooling blood and hemostasis, swelling and pain relieving. For jaundice, dysentery, urinary tract infections, scrofula, leukorrhea, rheumatic arthritis, hemoptysis is spitted blood, and is had blood in stool, bleeding from five sense organs or subcutaneous tissue;External application is controlled Traumatic injury, fracture, venomous snake bite, furuncle swelling toxin.The present invention is with all herbal medicine.Remaining is pharmacopeia kind.
Beneficial effect:
From in terms of theory of traditional Chinese medical science, Common Leafflower Herb, coriaceous knotweed rhizome, sharp knife Herba Sonchi Oleracei heat-clearing in we, relieving summer-heat, diuresis is monarch drug in a prescription, fine hair Ivy Tree Bark, great Ye Lepisorus thunbergianus (Kaulf.) Chings, red sage root dispelling, collateral-activating, promoting the circulation of qi are ministerial drug, and Radix Glycyrrhizae is adjuvant, and all medicine phases are closed, play altogether heat clearing and inflammation relieving, Promoting qi circulation and relieving pain is acted on, for treating gall stone.Rationally, compatibility is rigorous, through long-term clinical verification, curative effect for Formulation of the present invention Definitely.It is Chinese medicine to constitute, and is had no toxic side effect, cheap.
The novel in structural design of Chinese medicine pre-treatment machine of the present invention, it is made in inclination by electric rotating machine cooperation vibrating arm Chinese medicine on stock guide is slowly moved down, while being provided with magnetic annulus, is inclined because the surface of magnetic annulus can be connected to when rotated On oblique stock guide, such that it is able to the metal impurities in Chinese medicine are absorbed, when magnetic annulus rotates, can be collected by U-shaped impurity The vertical edge top surface of body is scraped, and so as to the metal impurities of absorption are struck off and be collected, thereby may be ensured that the energy of adsorption of magnetic annulus Power, solves and the low technical deficiency of metal impurities efficiency in Chinese medicine is removed in conventional art, and stability in use is good and greatly improves The efficiency of removal metal impurities.
Rationally, its simple operation effectively and quickly can be realized entering drug extract the structure setting of this medicinal extract dryer Row agitation, so as to be conducive to drug extract uniformly to dry, is greatly improved the drying efficiency of drug extract to a certain extent, solves The relatively low technical deficiency of drying efficiency in conventional art, strong applicability and practicality is good.
Brief description of the drawings
Fig. 1 is the structural representation of Chinese medicine pre-treatment machine
Fig. 2 is the structural representation of drug extract drying unit
Specific embodiment
Form, is described in further detail again to the above of the invention by the following examples, but should not be by this The scope for being interpreted as above-mentioned theme of the invention is only limitted to following example, and all technologies realized based on the above of the present invention are equal Belong to the scope of the present invention.
Embodiment 1:Take 20 parts of Common Leafflower Herb, 20 parts of coriaceous knotweed rhizome, 15 parts of sharp knife Herba Sonchi Oleracei, 22 parts of fine hair Ivy Tree Bark, great Ye bones 10 parts of board grass, 16 parts of the red sage root, 3 parts of medicinal materials of Radix Glycyrrhizae, are crushed, and are put into Chinese medicine pre-treatment machine processing, and medicinal material is added water to cook after treatment Twice, amount of water is 10 times of medicinal material weight amounts, decocts 2h, collecting decoction, and relative density is 1.10 when being concentrated into 65 DEG C, plus second Alcohol makes the percent by volume of alcohol content up to 65%, and stirring stands, filtering, and relative density is when filtrate decompression is concentrated into 65 DEG C 1.20 and ethanol is reclaimed, concentrate is put into medicinal extract drying machine drying, addition starch is made tablet.
Above-mentioned Chinese medicine pre-treatment machine is shown in Fig. 1, including device case 1, has feed hopper 2 in the top surface of described device housing 1, There is Chinese medicine derivation passage 3 in the sidewall bottom of described device housing 1, inclination stock guide 4, institute are provided with described device housing 1 The top for stating inclination stock guide 4 is connected on the inwall of device case 1 and in the underface of feed hopper 2, institute by rotary shaft 5 The bottom and Chinese medicine for stating inclination stock guide 4 are derived passage 3 and are connected, and vibrating seat is fixed with the bottom wall of described device housing 1 6, electric rotating machine 7 is fixed with the vibrating seat 6, wheel disc 8 is provided with the main shaft of the electric rotating machine 7, in the wheel disc 8 Card and incline stock guide 4 bottom between be provided with vibrating arm 9, the bottom of the vibrating arm 9 is connected to wheel by bearing pin 10 In the card of disk 8 and the vibrating arm 9 top be fixed on incline stock guide 4 bottom bottom surface, in the side of described device housing 1 Wall top is provided with strip through-hole 11, and the strip through-hole 11 is derived passage 3 and is arranged on same side with Chinese medicine, in described device Fixed U-shaped impurity collects body 12 on the outer wall of housing 1, central shaft 13 is provided with the strip through-hole 11, in described device There is the motor 14 being connected by belt transmission with the central shaft 13 on housing 1, belt is connected to the side of central shaft i.e. Can, magnetic annulus 15 is additionally provided with, the inwall of the magnetic annulus 15 is fixed on central shaft 13 by muscle bar 16, the magnetic circle Push up the side that the edge of ring 15 is connected on inclination stock guide 4 and the outer ledge of magnetic annulus 15 collects body 12 with U-shaped impurity End compresses contact.In the present embodiment, electric rotating machine and motor are the conventional motor of in the market, and it is only needed to according to correspondence Explanation be attached use.
The top for collecting body in the U-shaped impurity is provided with inclination scraper plate 16, and the inclination scraper plate is connected to magnetic annulus Surface.
The inclination stock guide is plastic material plate body.
The width for inclining scraper plate is identical with the width of magnetic annulus.
The drug extract drying unit is shown in Fig. 2, including casing 1, the carrying web plate 2 in the casing 1 is arranged on, in institute The bottom wall for stating casing 1 is provided with hot wind inlet 3, has chamber door 4 at the top of the casing 1, has perpendicular on the inwall of the casing 1 To guide chute 5, slotted eye 6 is provided with the upper side wall of the casing 1, the inner chamber and outside of the connection casing 1 of the slotted eye 6 are described The middle part for carrying web plate 2 is connected in casing 1 by rotary shaft 7, and the slotted eye 6 is with the vertical guide chute 5 with rotary shaft 7 Centered on be symmetrical arranged, it is described carrying web plate 2 one end be fixed with lifting slider 8, it is described carrying web plate 2 the other end consolidate Surely pole 9 is compressed, the lifting slider 8 is arranged in vertical guide chute 5 and described compresses pole 9 through the slotted eye 6 Casing 1 is stretched out, stress extension spring 10, the stress are provided between the bottom wall of the lifting slider 8 and the vertical guide chute 5 The bottom of extension spring is fixed on the bottom wall of vertical guide chute and the top of stress extension spring is fixed on lifting slider, in the case Motor 11 is fixed with the outer wall of body 1, eccentric wheel 12 is fixed with the main shaft of the motor 11, in the bias It is fixed with the raised wheel side of wheel 12 and compresses projection 13, the eccentric wheel 12 rotates under the drive of motor 11 and makes to compress Bump contact and being connected to is compressed on pole.In the present embodiment, motor is the conventional motor of in the market, its only need to according to Corresponding connection description is attached use.
Vertical backstop 14 is provided with the edge of the carrying web plate, the base of the vertical backstop is weldingly fixed on bearer network On the edge of plate.Can prevent drug extract from dropping off carrying web plate.
The projection that compresses is provided with anti-skidding burr 15 for arc block on the surface for compressing projection, described anti-skidding convex Line is arranged on and compressed on the contact surface of pole.Can increase and compress projection and compress the frictional force between pole.
The height of the anti-skidding burr is 5-10mm.
Its operation principle is summarized as follows:Drug extract is deposited on carrying web plate when in use, according to need in drying Start motor, now motor can band movable eccentric wheel rotation, when eccentric wheel rotates, compress projection and can contact and compress Pole simultaneously drives and compresses pole and move down, and now carrying web plate can rise centered on rotary shaft lifting slider, so that will Stress extension spring stretching stores power, and drug extract can be to a side shifting, when eccentric wheel continues to rotate, and compressing projection can progressively disengage Pole is compressed, the moment of pole disengaging is being compressed, lifting slider makes carrying web plate under the reset pulling force effect of stress extension spring Other end momentary reset is so as to drug extract be thrown and drops on carrying web plate, so that the agitation to drug extract is realized, Be conducive to making drug extract uniformly dry.
Embodiment 2:Take 30 parts of Common Leafflower Herb, 10 parts of coriaceous knotweed rhizome, 25 parts of sharp knife Herba Sonchi Oleracei, 18 parts of fine hair Ivy Tree Bark, great Ye bones 20 parts of board grass, 8 parts of the red sage root, 7 parts of medicinal materials of Radix Glycyrrhizae, crush, and are put into Chinese medicine pre-treatment machine processing, and medicinal material adds water to cook two after treatment Secondary, amount of water is 10 times of medicinal material weight and measures, decoction 2h, collecting decoction, and relative density is 1.10 when being concentrated into 65 DEG C, plus ethanol Make the percent by volume of alcohol content up to 65%, stirring stands, filtering, and relative density is 1.20 when filtrate decompression is concentrated into 65 DEG C And ethanol is reclaimed, and concentrate is put into medicinal extract drying machine drying, starch is added, pelletizing press sheet is made tablet.
Chinese medicine pre-treatment machine, medicinal extract dryer are with embodiment 1.
Embodiment 3:Take 25 parts of Common Leafflower Herb, 15 parts of coriaceous knotweed rhizome, 20 parts of sharp knife Herba Sonchi Oleracei, 20 parts of fine hair Ivy Tree Bark, great Ye bones 15 parts of board grass, 12 parts of the red sage root, 5 parts of medicinal materials of Radix Glycyrrhizae, are crushed, and are put into Chinese medicine pre-treatment machine processing, and medicinal material is added water to cook after treatment Twice, amount of water is 10 times of medicinal material weight amounts, decocts 2h, collecting decoction, and relative density is 1.10 when being concentrated into 65 DEG C, plus second Alcohol makes the percent by volume of alcohol content up to 65%, and stirring stands, filtering, and relative density is when filtrate decompression is concentrated into 65 DEG C 1.20 and ethanol is reclaimed, concentrate is put into medicinal extract drying machine drying, add starch, pelletizing press sheet is made tablet.
Chinese medicine pre-treatment machine, medicinal extract dryer are with embodiment 1.
Embodiment 4:Clinical trial data of the present invention to gall stone
1. it is selected in 30 gall stone patients altogether, is made a definite diagnosis with B ultrasonic.
2. the standard of curative effect evaluation:Cure:Calculus is excluded completely, and pain all disappears, and sign improves completely, happy, It is in high spirits.It is effective:Calculus is excluded substantially, and pain disappears, and sign improves completely, happy, in high spirits.Effectively:Calculus Part excludes, and pain disappears substantially, and sign makes moderate progress, and mood and spirit are preferably.It is invalid:Calculus can not be excluded, and pain still has, Sign and symptom improve not substantially or without improvement.
3. in 30 cases accepted for medical treatment, treated through 6 months, wherein curing 15, effective 10, effective 1, invalid 2 Example, total effective rate is up to 93.3%.Show that the present invention has highly significant effect to treatment Patients with Cholelithiasis.
Embodiment 5:Active ingredient determation of tanshinone ⅡA experimental study data in the present invention
1. Experimental agents:The present invention is prepared by embodiment 1-3 methods.Control group is not used at Chinese medicine pre-treatment machine Reason, and prepared using ordinary extract dryer.
2. instrument:High performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515);P200 high-pressure pumps; The UV-detectors of Waters 2487 and GJ605 type high pressure six-way injection valves;Chromatographic column is Hypersil ODSC18 posts (4.6mm ×250mm,5μm);Data acquisition and treatment are using HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
3. condition determination:Using high performance liquid chromatography, by version official method in 2015, with octadecylsilane bonded silica Glue is filler;Column temperature:25℃;Mobile phase is methanol-water (80:20), flow velocity is 1.0mL/min, and Detection wavelength is 270nm; Flow velocity:1ml/min.Number of theoretical plate is calculated by tanshinone IIA peak and all should be not less than 2000.
4. experimental result
Determation of tanshinone ⅡA result in each embodiment
Sample source Tanshinone IIA content (mg/ pieces)
Embodiment 1 3.98
Embodiment 2 4.13
Embodiment 3 3.78
Control group 1.08
It can be seen from result of the test according to upper table, active constituent content in Tablets prepared by embodiment of the present invention 1-3 Apparently higher than control group.
Embodiment 6:Content of beary metal determination experiment research data in the present invention
1. Experimental agents:The present invention is prepared by embodiment 1-3 methods.Control group is not used at Chinese medicine pre-treatment machine Reason, and prepared using ordinary extract dryer.
2. method:The lead of said medicine, cadmium and mercury content with atom spectrophotometry.Result shows,
Sample source Lead (mg/kg) Cadmium (mg/kg) Mercury (mg/kg)
Embodiment 1 0.02 0.27 0.34
Embodiment 2 0.01 0.29 0.41
Embodiment 3 0.02 0.25 0.36
Control group 0.31 0.78 2.37
It can be seen from result of the test, content of beary metal is significantly lower than in Tablets prepared by embodiment of the present invention 1-3 Control group.
Embodiment 7:The present invention suppresses the experimental study data of Mouse cartilage ATDC5 cells propagation
1. experiment material
1.1 experiment cell lines:Mouse cartilage ATDC5 cells, Nanjing Medical University's laboratory cell storehouse, DMEM+10% FBS cellar cultures.
1.2 Experimental agents
Research medicine:The present invention is prepared by the method for embodiment 1.
Liquid liquid storage:The 100mg present invention is weighed, is dissolved in 5ml absolute ethyl alcohols, 0.2 μm of filter filtering, 500 μ l doff pipes Packing, -20 DEG C of storages, while 0.2 μm of filter filters absolute ethyl alcohol in case control group is used.
1.3 experiment reagents
DMEM (GIBCO company Cat.No.12100-061Lot.No.758137);Hyclone (Zhejiang day Hangzhoupro biology section Skill Co., Ltd Lot.No.100419);NaHCO3 (the long hundred million chemical reagent Co., Ltd Cat.No.11810- in Shanghai 033Lot.No.1088387);Trypsin (AMRESCO companies lot numbers:2010/04);EDTA (AMRESCO companies lot numbers: 2009/10);Penicillin G Sodium Salt (AMRESCO companies lot numbers:2010242);Streptomycin Sulfate (AMRESCO companies lot numbers:2010382);Absolute ethyl alcohol (Nanjing Chemistry Reagent Co., Ltd.'s lot number: 080310182);MTT (Biosharp lot numbers:0793);PBS (laboratory autogamy);
1.4 experiment equipments
Lycra inverted microscope (German Leica models:DM1L);It can be seen that-ultraviolet light micropore board detector (MD companies of the U.S. Model:SPECTRA MAX 190);CO2 incubators (FORMA models:3111);Super-clean bench (the safe and sound company system moulding of Su Jing groups Number:SW-CJ-ZFD);Pure water meter (Spring companies of U.S. model:S/N 020579);Accurate pipettor (French Gilson Inc Model:P2);Electronic balance (German Sai Duolisi Co., Ltds model:BT323S);Full-automatic high-pressure autoclave (Japanese SANYO Company's model:MLS-3020);Table electrothermal air dry oven (Shanghai precision experimental facilities company model:DHG9123A);Refrigerator (Siemens Company's model:KG18V21TI);Liquid nitrogen container (CBS models:2001);Low speed centrifuge (Anting Scientific Instrument Factory, Shanghai Model:KA-1000);0.2 μm of filter (MILLIPORE model:SLGP033RB);10cm culture dishes (NEST companies), the training of 96 holes Support plate (NEST companies);Cell counting count board;Centrifuge tube, pipette, Tips are some.
2. experimental technique
1) Mouse cartilage ATDC5 cells carry out cellar culture (10cm cultures with DMEM+10%FBS in 37 DEG C, 5%CO2 Ware), when cell growth to logarithmic phase, cell is collected, nutrient solution is discarded, PBS is rinsed 3 times, adds 3ml0.25% tryptoses Enzyme -0.04%EDTA, after 37 DEG C of digestion 2min, is added thereto to 5ml complete medium neutralization reactions, by its turn after piping and druming cell Enter in centrifuge tube, 1000rpm centrifugation 5min adjust 3 × 104/ml of concentration of cell suspension.
2) in cell kind being entered into 96 well culture plates, the μ l of cell suspension 180, culture plate is added to be put into cell culture incubator per hole (37 DEG C, 5%CO2) cellar culture.
3) it is general long to 50%-70% according to cell growth status, solution of the present invention is added, continue to cultivate 24h.
4) 20 μ l MTT solution (5mg/ml, i.e. 0.5%MTT) are added after 24h, continues to cultivate 4h.
5) buckle method falls supernatant after 4h, is gently patted dry with blotting paper, and 200 μ l dimethyl sulfoxide (DMSO)s are added per hole, puts shaking table Upper low-speed oscillation 10min, makes crystal fully dissolve.The light absorption value in each hole is measured at enzyme-linked immunosorbent assay instrument 490nm.
6) while setting background (being not added with cell, only add nutrient solution), (cell, the medicine dissolving of same concentrations are situated between control wells Matter, nutrient solution, MTT, dimethyl sulfoxide (DMSO)), 6 multiple holes of every group of setting.
7) result is represented the inhibiting rate of cell with medicine:
Cell proliferation inhibiting rate (%)=(control wells OD values-dosing holes OD values)/control wells OD value × 100%.Experiment weight It is multiple 3 times.
3. statistical disposition
Checked using the correlation analysis in the softwares of Microsoft Excel 2003 and Student t, data with mean ± S.D. represent.
4. experimental result
Statistical result showed after mtt assay experiment, compares, when dosage reaches 5mg/ml, to Mouse cartilage with control group Variant (the P of ATDC5 cell inhibitory effects<0.05), dosage difference in 10mg/ml has conspicuousness (P<0.01) agent, is worked as Amount has significant difference (P in pole when reaching 15-20mg/ml<0.001).
The present invention influences to study on Mouse cartilage ATDC5 cell inhibitory effects
Note:Compare with control group, * P<0.01;**P<0.001
5. experiment conclusion:The present invention can suppress Mouse cartilage ATDC5 cells propagation, reduce Mouse cartilage ATDC5 cells Cell growth number, the effect be in dose dependent.

Claims (10)

1. a kind of Chinese medicine composition for treating gall stone, it is characterised in that it is extracted by the bulk drug of following parts by weight and prepared Obtain:Common Leafflower Herb 20-30 parts, coriaceous knotweed rhizome 10-20 parts, 15-25 parts of sharp knife Herba Sonchi Oleracei, 18-22 parts of fine hair Ivy Tree Bark, great Ye dominoes It is careless 10-20 parts, red sage root 8-16 parts, Radix Glycyrrhizae 3-7 parts.
2. as claimed in claim 1 treatment gall stone Chinese medicine composition, it is characterised in that it by following parts by weight raw material Medicine is extracted and prepared:25 parts of Common Leafflower Herb, 15 parts of coriaceous knotweed rhizome, 20 parts of sharp knife Herba Sonchi Oleracei, 20 parts of fine hair Ivy Tree Bark, great Ye Lepisorus thunbergianus (Kaulf.) Chings 15 parts, 12 parts of the red sage root, 5 parts of Radix Glycyrrhizae.
3. the Chinese medicine composition of gall stone is treated as claimed in claim 1, it is characterised in that preparation method comprises the following steps: Take Common Leafflower Herb, coriaceous knotweed rhizome, sharp knife Herba Sonchi Oleracei, fine hair Ivy Tree Bark, great Ye Lepisorus thunbergianus (Kaulf.) Chings, the red sage root, licorice medicinal materials to merge, crush, be put into Chinese medicine pre-treatment machine processing, medicinal material is added water to cook twice after treatment, and amount of water is 10 times of amounts of medicinal material weight, decocts 2h, is closed And decocting liquid, relative density is 1.10 when being concentrated into 65 DEG C, plus ethanol makes the percent by volume of alcohol content up to 65%, and stirring stands, Filtering, relative density is 1.20 and reclaims ethanol when filtrate decompression is concentrated into 65 DEG C, and concentrate is put into medicinal extract drying machine drying, Addition auxiliary material is made capsule, tablet, granule.
4. the Chinese medicine composition of gall stone is treated as claimed in claim 3, it is characterised in that Chinese medicine pretreating machine in preparation method Device includes device case, has feed hopper in the top surface of described device housing, has Chinese medicine to lead in the sidewall bottom of described device housing Go out passage, inclination stock guide is provided with described device housing, the top of the inclination stock guide is connected to dress by rotary shaft Put on the inwall of housing and the underface in feed hopper, bottom and the Chinese medicine of the inclination stock guide are derived passage and is connected, It is characterized in that:Vibrating seat is fixed with the bottom wall of described device housing, electric rotating machine is fixed with the vibrating seat, The main shaft of the electric rotating machine is provided with wheel disc, and vibration is provided between the card of the wheel disc and the bottom of inclination stock guide Bar, the bottom of the vibrating arm is connected in the card of wheel disc by bearing pin and the top of the vibrating arm is fixed on inclination guide The bottom bottom surface of plate, strip through-hole is provided with the top side wall of described device housing, and the strip through-hole derives passage with Chinese medicine It is arranged on same side, fixed U-shaped impurity collects body on the outer wall of described device housing, is set in the strip through-hole There is central shaft, there is the motor being connected by belt transmission with the central shaft on described device housing, be additionally provided with magnetic Annulus, the inwall of the magnetic annulus is fixed on center shaft by muscle bar, and the edge of the magnetic annulus is connected to inclination and leads On flitch and the outer ledge of magnetic annulus and U-shaped impurity collect the side top of body and compresses and contact.
5. the Chinese medicine composition of gall stone is treated as claimed in claim 4, it is characterised in that Chinese medicine pretreating machine in preparation method The top that U-shaped impurity described in device collects body is provided with inclination scraper plate, and the inclination scraper plate is connected to the surface of magnetic annulus.
6. the Chinese medicine composition of gall stone is treated as claimed in claim 4, it is characterised in that Chinese medicine pretreating machine in preparation method It is plastic material plate body that stock guide is inclined described in device, and the width of the inclination scraper plate is identical with the width of magnetic annulus.
7. the Chinese medicine composition of gall stone is treated as claimed in claim 3, it is characterised in that medicinal extract dryer bag in preparation method Casing is included, the carrying web plate in the casing is arranged on, hot wind inlet is provided with the bottom wall of the casing, in the casing Chamber door is arranged at top, it is characterised in that:There is vertical guide chute on the inwall of the casing, be provided with the casing upper side wall Slotted eye, the inner chamber and outside of the slotted eye connection casing, the middle part for carrying web plate is connected in casing by rotary shaft, institute State slotted eye to be symmetrical arranged centered on rotary shaft with the vertical guide chute, lifting is fixed with one end of the carrying web plate Sliding block, is fixed with and compresses pole in the other end of the carrying web plate, the lifting slider be arranged in vertical guide chute and It is described to compress pole and stretch out casing through the slotted eye, set between the bottom wall of the lifting slider and the vertical guide chute There is stress extension spring, the bottom of the stress extension spring is fixed on the bottom wall of vertical guide chute and the top of stress extension spring is fixed on On lifting slider, motor is fixed with the outer wall of the casing, bias is fixed with the main shaft of the motor Wheel, is fixed with the raised wheel side of the eccentric wheel and compresses projection, and the eccentric wheel rotates simultaneously under the drive of motor Make to compress bump contact and be connected to compress on pole.
8. the Chinese medicine composition of gall stone is treated as claimed in claim 7, it is characterised in that in preparation method in medicinal extract dryer The edge for carrying web plate is provided with vertical backstop, and the base of the vertical backstop is weldingly fixed on the edge for carrying web plate.
9. the Chinese medicine composition of gall stone is treated as claimed in claim 7, it is characterised in that in preparation method in medicinal extract dryer The projection that compresses is provided with anti-skidding burr for arc block on the surface for compressing projection, the anti-skidding burr be arranged on Compress on the contact surface of pole, the height of the anti-skidding burr is 5-10mm.
10. the Chinese medicine composition that gall stone is treated described in claim 1 is preparing suppression Mouse cartilage ATDC5 cell proliferations In application.
CN201611031686.6A 2016-11-18 2016-11-18 A kind of Chinese medicine composition and preparation method and application for treating gall stone Withdrawn CN106728013A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018938A (en) * 2010-12-09 2011-04-20 王玉青 Traditional Chinese medicine prescription for treating cholelithiasis
CN104352995A (en) * 2014-11-30 2015-02-18 李坤 Medicine for treating gall-stone and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018938A (en) * 2010-12-09 2011-04-20 王玉青 Traditional Chinese medicine prescription for treating cholelithiasis
CN104352995A (en) * 2014-11-30 2015-02-18 李坤 Medicine for treating gall-stone and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张俊庭等: "《中华名医高新诊疗通鉴》", 31 May 2000, 中医古籍出版社 *

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