CN106727866A - A kind of preparation of antiperspirant cream compositions and its application in treatment eczema - Google Patents
A kind of preparation of antiperspirant cream compositions and its application in treatment eczema Download PDFInfo
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- CN106727866A CN106727866A CN201710181925.4A CN201710181925A CN106727866A CN 106727866 A CN106727866 A CN 106727866A CN 201710181925 A CN201710181925 A CN 201710181925A CN 106727866 A CN106727866 A CN 106727866A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The present invention relates to a kind of composition preparing technical field, the preparation and its application on eczema is treated of particularly a kind of antiperspirant cream compositions.Described antiperspirant cream compositions, by 20 35 weight portion kiss-mes, 25 weight portion stringy stonecrops, 35 weight portion centellas, 2 10 weight portion Asian puccoons, the mixing of 45 73 weight portion tea oil, 20 25 parts by weight of propylene glycol, 24 30 beeswaxs, 8 12 weight portion lecithin, 24 30 weight portion tristerins, 23 part by weight of vitamin E, the acid of 23 parts by weight of lemon（50% solution）Mixing composition.Using when, by emulsifiable paste of the invention smear affected part, using exposure treat, at interval of 46 hours smear once.The present invention prepares easy, and easy to carry, medicine source is abundant, pure natural, without any side effects, pharmacy low cost, can substantially reduce treatment cost, mitigates patient economy burden.
Description
Technical field
The present invention relates to a kind of composition preparing technical field, the preparation of particularly a kind of antiperspirant cream compositions and its in treatment
Application in eczema.
Background technology
Eczema is a kind of scytitis reaction of the acute pruritus caused by various internal and external factors.Divide acute, subacute, slow
Three phases of property.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plumpness.Some patients directly translate into chronic eczema.Skin damaged has
The features such as polymorphy, symmetry, itch and easy recurrent exerbation.
Eczematosis is internal and external reasonses interaction result because of complexity, often.Internal cause for example chronic digestive system disease, stress,
Insomnia, fatigue, emotional change, endocrinopathy, infection, dysbolism etc., external cause such as living environment, weather become
Change, food etc. can influence the generation of eczema.Environmental stimuli such as daylight, cold, drying, sweltering heat, hot water are scalded and various dynamic
Thing fur, plant, cosmetics, soap, staple fibre etc. can induce.It is that a kind of delayed that the complicated inside and outside factor causes becomes
State is reacted.The skin damaged of general eczema is polymorphy, and based on erythema, papule, papulo-vesicle, fash center is obvious, gradually to surrounding
Scatter, indefinite border, diffusivity has and oozes out tendency, chronic person then has infiltration plump.The course of disease is irregular, in recurrent exerbation, itch
Acutely.
At present, many for oral administration, Chinese herbal medicine for external use things are disclosed successively, effect is not also how obvious, treatment is still easily anti-after taking a turn for the better
Recurrence is made, hardly possible radical cure.
The content of the invention
It is an object of the invention to provide a kind of antiperspirant cream compositions, preparation method and using said composition in treatment eczema
Application.There is obvious curative effect to eczema, prepare easy, easy to use, the lighter symptom of eczema, skin is without scar after healing.
Antiperspirant cream compositions of the present invention, by 20-35 weight portions kiss-me, 2-5 weight portions stringy stonecrop, 3-5 weight portions
Centella, 2-10 weight portions Asian puccoon, the mixing of 45-73 weight portions tea oil, 20-25 parts by weight of propylene glycol, 24-30 beeswaxs, 8-12 weight
Amount part lecithin, 24-30 weight portions tristerin, the acid of 2-3 part by weight of vitamin E, 2-3 parts by weight of lemon（50% solution）
Mixing composition.
Antiperspirant cream compositions of the present invention are prepared method by the following technical programs：
1）By propane diols, beeswax and lecithin according to weight ratio mix, and under the conditions of 70 DEG C heating stirring to completely mix
Close uniform；
2）Kiss-me, stringy stonecrop, centella, Asian puccoon drying are milled into fine powder, tea oil composition is mixed into tea oil；
3）Tristerin is heated to 70 DEG C, vitamin E is added after mixing with tea oil composition, mixed to complete breast
Change；
4）Mixture after emulsification is added to step 1）Mixture in, it is homogeneous after be cooled to 35 DEG C；Add citric acid
（50% solution）, stir and evenly mix, obtain final product and contain antiperspirant cream compositions.
Application of the antiperspirant cream compositions of the present invention in treatment eczema, refers to when applying, emulsifiable paste of the invention to be applied
Affected part is smeared, is treated using exposure, smeared once at interval of 4-6 hours.
Beneficial effects of the present invention are easy to provide a kind of preparation, easy to carry, expose coating, do not wrap up, and do not make skin graft, and resist
Infection, anti-leakage liquid, short treating period, effect is good, without scar after wound healing, treats the antiperspirant cream compositions of eczema, advantages of the present invention
It is easy to use, medicine source is abundant, pure natural, without any side effects, pharmacy low cost.Antiperspirant cream compositions prescription compatibility of the invention
Proper, preparation method is unique, for various eczema treatments, there is the curative effect of uniqueness：1st, it is antipruritic fast and thorough, 10-30 minutes
Sufferings, and treatment overall process no pain is completely eliminated, no pain treatment is truly realized.2nd, resistance infection is strong, the breast
Composite cream resistance infection is strong, without any side effects to the surface of a wound without irritating.3rd, healing rate is fast, and the antiperspirant cream compositions are to receiving
The histocyte of wound realizes Complicated primary, is substantially shorter the phase of oozing out, across infection period, healing stage in advance, so as to shorten
Treatment course.5th, it is easy to use, using the antiperspirant cream compositions, can bandaging method for treating, can also expose treatment, patient can be greatly reduced frequently
The pain of numerous upset, decreases nursing work load.6th, antiperspirant cream compositions of the invention, are easy to get using raw material, cheap, system
Preparation Method is easy, and treatment consumption is few, therefore can substantially reduce treatment cost, mitigates patient economy burden.
Specific embodiment
To describe technology contents of the invention, structural feature, the objects and the effects in detail, below in conjunction with implementation method
It is explained in detail.
Kiss-me（Scientific name：Saxifraga stolonifera Curt.）Also known as stone lotus, gold thread hang lotus, tiger ear
Deng.Whip flagellum is elongated, the close glandular hairs long that are curled, and has flakey leaf.Contain Bergenin in kiss-me leaf, quercitrin, Quercetin does not have
Gallate-based, protocatechuic acid, butanedioic acid and mesaconic acid.Stem contains catechol.Root contains volatile oil.In addition also divide from kiss-me
Arbutin is obtained, chlorogenic acid, Quercetin -5-O- glycosides remove first Bergenin, amino acid all herbal medicines；It is slight bitter, pungent,
It is cold, it is slightly poisonous；Expelling wind and clearing away heat, removing pattogenic heat from the blood and toxic material from the body.
Stringy stonecrop contains the compositions such as borneol, eucalyptol, linalool.Motherland's medical science thinks：It is stringy stonecrop taste micro-sweet, pungent, cool, have
Relieving summer-heat promotes the production of body fluid, and powder for improving appetite is strongly fragrant, solves taking poison and growing muscle due, the effect of cough-relieving.Cure mainly hot summer weather dizziness, vomiting, pyreticosis polydipsia, obstruction of the circulation of vital energy stomach is vexed, cough
The disease such as cough.Conventional stringy stonecrop among the people is decocted water and gives baby's drink-service, there is clearing heat and detoxicating effect.
Centella has the effects such as Eradicates wind, solid intestines, the clear heat of improving eyesight, removing damp-heat, removing toxic substances diuresis.
Asian puccoon contains allantoin（allantoin）Composition, neoblast can be stimulated to grow, external curing wound can promote
Enter wound healing.
It is an advantage of the invention that easy to use, medicine source is abundant, pure natural, without any side effects, expense is low.
Embodiment 1
The weight of the present embodiment raw material is：2000g kiss-mes, 500g stringy stonecrops, 500g centellas, 200g Asian puccoons,
The mixing of 7300g tea oil, 2000g propane diols, 24 beeswaxs, 1200g lecithin, 3000g tristerins, 300g vitamin Es,
200g citric acids（50% solution）.
Antiperspirant cream compositions described in the present embodiment are prepared method by the following technical programs：
1）By propane diols, beeswax and lecithin according to weight ratio mix, and under the conditions of 70 DEG C heating stirring to completely mix
Close uniform；
2）Kiss-me, stringy stonecrop, centella, Asian puccoon drying are milled into fine powder, tea oil composition is mixed into tea oil；
3）Tristerin is heated to 70 DEG C, vitamin E is added after mixing with tea oil composition, mixed to complete breast
Change；
4）Mixture after emulsification is added to step 1）Mixture in, it is homogeneous after be cooled to 35 DEG C；Add citric acid
（50% solution）, stir and evenly mix, obtain final product and contain antiperspirant cream compositions.
When medication, ointment of the invention is smeared into affected part, treated using exposure, at interval of 4 hours continuous smearings once.
Embodiment 2
The weight of the present embodiment raw material is：3000g kiss-mes, 300g stringy stonecrops, 400g centellas, 800g Asian puccoons,
The mixing of 6000g tea oil, 2200g propane diols, 26 beeswaxs, 1000g lecithin, 3000g tristerins, 300g vitamin Es,
200g citric acids（50% solution）.
Antiperspirant cream compositions preparation method described in the present embodiment 1 is identical with embodiment.
When medication, ointment of the invention is smeared into affected part, treated using exposure, at interval of 5 hours continuous smearings once.
Embodiment 3
The weight of the present embodiment raw material is：3000g kiss-mes, 500g stringy stonecrops, 400g centellas, 500g Asian puccoons,
The mixing of 6500g tea oil, 2200g propane diols, 28 beeswaxs, 800g lecithin, 2800g tristerins, 200g vitamin Es,
200g citric acids（50% solution）.
Antiperspirant cream compositions preparation method described in the present embodiment 1 is identical with embodiment.
When medication, ointment of the invention is smeared into affected part, treated using exposure, at interval of 6 hours continuous smearings once.
Embodiment 4
The weight of the present embodiment raw material is：3500g kiss-mes, 500g stringy stonecrops, 300g centellas, 300g Asian puccoons,
The mixing of 7300g tea oil, 2200g propane diols, 2400g beeswaxs, 1200g lecithin, 2800g tristerins, 200g vitamins
E, 200g citric acid（50% solution）.
Antiperspirant cream compositions preparation method described in the present embodiment 1 is identical with embodiment.
When medication, ointment of the invention is smeared into affected part, treated using exposure, at interval of 6 hours continuous smearings once.
Embodiment 5
The antiperspirant cream compositions that embodiment 1-4 is obtained are applied to 300 eczema patients（Wherein have 100 be pregnant woman's eczema patients,
Have 100 to be is the infant eczema patient of 1 month to 3 years old at the age, have 100 be non-pregnant woman and infant no special crowd
Adult eczema patients）Affected part, treated using exposure, at interval of 4-6 hour it is continuous smear once, to the symptom of patient with control
More the time is recorded, and record result see the table below 1.
Table 1
| Embodiment | Symptom | Healing time | Infection | Scar |
| 1 | Antipruritic effect can be reached after 12 minutes | 12-48 hours | In the absence of infection phenomenons | Do not stay scar |
| 2 | Antipruritic effect can be reached after 10 minutes | 12-48 hours | In the absence of infection phenomenons | Do not stay scar |
| 3 | Antipruritic effect can be reached after 12 minutes | 12-48 hours | In the absence of infection phenomenons | Do not stay scar |
| 4 | Antipruritic effect can be reached after 11 minutes | 12-48 hours | In the absence of infection phenomenons | Do not stay scar |
As shown in Table 1, antiperspirant cream compositions of the invention can be antipruritic in 10-30 minutes, and healing time is short, with strong anti-sense
Dye power, while without scar after wound healing.
It is below the specific case description of present invention treatment eczema.
1st, Lin, Fuzhou City, Fujian Province Yongtai County Chinese parasol tree town child, 6 months are big, eczema, after smearing eczema ointment, 12 points
The sense of clock sufferings disappears, and at interval of 4 hours continuous smearings once, 3 recoveries from illness is used in conjunction, without scar.
2nd, Lu so-and-so, Fuzhou City, Fujian Province Yongtai County Tongan City town child, 2 months big, eczema, after smearing eczema ointment, 10 points
The sense of clock sufferings disappears, and at interval of 6 hours continuous smearings once, 2 recoveries from illness is used in conjunction, without scar.
3rd, king so-and-so, Fuzhou City, Fujian Province Yongtai County Tongan City town Sanyo villager, 15 years old, eczema, smear eczema ointment after, 10
Minute sufferings sense disappears, and at interval of 4 hours continuous smearings once, 5 recoveries from illness is used in conjunction, without scar.
4th, Yan, Fuzhou City, Fujian Province Yongtai County ocean town child, 2 months are big, because paper diaper improper use causes eczema,
After smearing eczema ointment, sufferings sense in 10 minutes disappears, and at interval of 6 hours continuous smearings once, 5 recoveries from illness is used in conjunction, without scar.
5th, Yan so-and-so, Fuzhou City, Fujian Province Yongtai County ocean town child, 2 months big, because paper diaper improper use causes wet
Rash, after smearing eczema ointment, sufferings sense in 11 minutes disappears, and at interval of 4 hours continuous smearings once, 3 recoveries from illness is used in conjunction, without scar.
From 5 isolation given above, external application eczema medicament of the present invention treats eczema excellent, using this
Invention can make patient palliate the agonizing sufferings, and low in treatment cost, and Clinical practice is convenient, and recovery from illness is fast, has no side effect.
Embodiments of the invention are the foregoing is only, the scope of the claims of the invention is not thereby limited, it is every to utilize this hair
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (2)
1. a kind of preparation of antiperspirant cream compositions and its application in treatment eczema, it is characterised in that described antiperspirant cream compositions,
By 20-35 weight portions kiss-me, 2-5 weight portions stringy stonecrop, 3-5 weight portions centella, 2-10 weight portions Asian puccoon, 45-73 weight
The mixing of part tea oil, 20-25 parts by weight of propylene glycol, 24-30 beeswaxs, 8-12 weight portions lecithin, 24-30 weight portion glycerol stearates
Ester, the acid of 2-3 part by weight of vitamin E, 2-3 parts by weight of lemon（50% solution）Mixing composition；
Described antiperspirant cream compositions are prepared method by the following technical programs：
1）By propane diols, beeswax and lecithin according to weight ratio mix, and under the conditions of 70 DEG C heating stirring to completely mix
Close uniform；
2）Kiss-me, stringy stonecrop, centella, Asian puccoon drying are milled into fine powder, tea oil composition is mixed into tea oil；
3）Tristerin is heated to 70 DEG C, vitamin E is added after mixing with tea oil composition, mixed to complete breast
Change；
4）Mixture after emulsification is added to step 1）Mixture in, it is homogeneous after be cooled to 35 DEG C；Add containing 50%
Citric acid solution, stirs and evenly mixs, and obtains final product and contains antiperspirant cream compositions.
2. a kind of preparation of antiperspirant cream compositions and its application in treatment eczema, it is characterised in that described antiperspirant cream compositions exist
When in treatment eczema, emulsifiable paste of the invention is smeared into affected part, treated using exposure, smeared once at interval of 4-6 hours.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710181925.4A CN106727866A (en) | 2017-03-24 | 2017-03-24 | A kind of preparation of antiperspirant cream compositions and its application in treatment eczema |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710181925.4A CN106727866A (en) | 2017-03-24 | 2017-03-24 | A kind of preparation of antiperspirant cream compositions and its application in treatment eczema |
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| CN106727866A true CN106727866A (en) | 2017-05-31 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309534A (en) * | 2011-09-07 | 2012-01-11 | 福州职业技术学院 | Chinese medicinal herb composition for treating burns and scalds, its preparation method and application |
| CN105232824A (en) * | 2015-11-26 | 2016-01-13 | 福建胜华农业科技发展有限公司 | Tea oil composition and preparing method and application thereof |
| CN106236841A (en) * | 2015-10-18 | 2016-12-21 | 上海健立达医疗科技有限公司 | A kind of cream treating infant eczema |
| CN106860501A (en) * | 2017-03-24 | 2017-06-20 | 福建师范大学 | A kind of herbal composite and its application in treatment eczema |
-
2017
- 2017-03-24 CN CN201710181925.4A patent/CN106727866A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309534A (en) * | 2011-09-07 | 2012-01-11 | 福州职业技术学院 | Chinese medicinal herb composition for treating burns and scalds, its preparation method and application |
| CN106236841A (en) * | 2015-10-18 | 2016-12-21 | 上海健立达医疗科技有限公司 | A kind of cream treating infant eczema |
| CN105232824A (en) * | 2015-11-26 | 2016-01-13 | 福建胜华农业科技发展有限公司 | Tea oil composition and preparing method and application thereof |
| CN106860501A (en) * | 2017-03-24 | 2017-06-20 | 福建师范大学 | A kind of herbal composite and its application in treatment eczema |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
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Application publication date: 20170531 |