CN106725371A - A kind of lesions located in deep brain bleeding detecting system of many batteries - Google Patents
A kind of lesions located in deep brain bleeding detecting system of many batteries Download PDFInfo
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- CN106725371A CN106725371A CN201611260929.3A CN201611260929A CN106725371A CN 106725371 A CN106725371 A CN 106725371A CN 201611260929 A CN201611260929 A CN 201611260929A CN 106725371 A CN106725371 A CN 106725371A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02042—Determining blood loss or bleeding, e.g. during a surgical procedure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
- A61B5/031—Intracranial pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Abstract
The invention discloses a kind of lesions located in deep brain bleeding detecting system of many batteries, including at least one lesions located in deep brain device and device outside, the lesions located in deep brain device includes stimulating electrode, the hemoglobin sensor set near the stimulating electrode, pulse generator module, at least charge coil, a main battery, an at least reserve battery, processor module and first communication module；The device outside includes second communication module and warning module；Processor module control charge coil charges to an at least main battery and an at least reserve battery, and an at least reserve battery described in control charges to an at least main battery.The electric energy of lesions located in deep brain bleeding detecting system is quickly supplemented by such charging modes.
Description
Technical field
The present invention relates to lesions located in deep brain bleeding detecting system, in particular to a kind of lesions located in deep brain of many batteries
Bleeding detecting system.
Background technology
Lesions located in deep brain（DBS）Have been developed as the damage hand commonly used in traditional stereotaxis functional neurosurgery surgery
The alternative of art.It is a kind of effective method that DBS has confirmed, the characteristics of have invertibity and adjustability due to it, significantly
Reduce the disability rate of operation.It is used to treat dyskinetic disease, Parkinson's, epilepsy, myodystony, clump by increasing
The diseases such as collection property pain, obsession, Gilles de la Tourette's syndrome, depression.But lesions located in deep brain there is also risk, common
There are postoperative Brain edema, bleeding etc., the safety to patient threatens.
The function of lesions located in deep brain system of the prior art is more and more, such as increased the function of detection bleeding,
Cause battery power not enough, the electric energy of supplement lesions located in deep brain bleeding detecting system is current technology difficult point in time.
The content of the invention
It is an object of the invention in overcoming the shortcomings of above-mentioned technology, there is provided a kind of lesions located in deep brain bleeding of many batteries
Detecting system, the system includes：At least one lesions located in deep brain device and device outside, lesions located in deep brain device include stimulating electricity
Pole, the hemoglobin sensor set near stimulating electrode, pulse generator module, charge coil, at least a main battery, at least
One reserve battery, processor module and first communication module；Processor module control charge coil is to an at least main battery and extremely
A few reserve battery charges；Processor module controls an at least reserve battery to be charged to an at least main battery.Device outside includes
Second communication module, warning module；The processor module control pulse generator module of lesions located in deep brain device is according to storage
The related program generation stimulus signal of stimulation parameter, and stimulus signal is sent to the contact of stimulating electrode, discharged by contact
Electro photoluminescence is carried out to target area；Meanwhile, hemoglobin sensor is real-time or intermittent sensor proximity region is examined
Survey, processor module judges whether to detect hemoglobin, once detecting, then may produce bleeding at stimulating electrode, will go out
Blood signal is transmitted to device outside second communication module by first communication module, and warning module carries out bleeding pattern early warning.
Further, deep brain stimulation bleeding detecting system may also include the cerebral sensor set near stimulating electrode,
When detecting hemoglobin, cerebral sensor is detected to sensor proximity region, and processor module judges whether detection
Whether cerebral is more than predetermined threshold value, and cerebral exception is judged as more than predetermined threshold value, by cerebral abnormal signal by the first communication mould
Block is transmitted to device outside second communication module, and warning module carries out cerebral abnormal patterns early warning.
Further, stimulating electrode may include first section, stage casing, latter end；First section, stage casing, latter end include at least one set respectively
Electrode contacts group, a hemoglobin sensor and a cerebral sensor；Every group of electrode contacts at least include that two electrodes are touched
Point；Electrode contacts are connected to extended line by conductor respectively, and first section, stage casing, the electrode contacts group of latter end are along electrode bearing of trend
Set, every group of electrode contacts are set along electrode circumferencial direction.
Further, main battery and reserve battery are Li-Ion rechargeable battery or other rechargeable batteries.
By the system, effectively, timely the postoperative Brain edema of patient, bleeding can be monitored.
Brief description of the drawings
Fig. 1 is a kind of lesions located in deep brain bleeding detecting system figure of many batteries of the invention.
Fig. 2 is electrode figure of the invention.
The device outside of 11. lesions located in deep brain device 12..
21. stimulating electrode, 22. hemoglobin sensor, 23. impulse generator, 24. processor module 25. first communicates
Module.
The warning module of 31. second communication module 32..
100. reaction type lesions located in deep brain electrode latter ends；200. reaction type lesions located in deep brain electrode stage casings；300.
Reaction type lesions located in deep brain electrode first section；101st, 201,301. hemoglobin sensor；102nd, 202,302. cerebrals sensing
Device；103rd, 203,303. reaction type lesions located in deep brain electrode contacts；104th, 204,304. insulator.
Specific embodiment
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 shows a kind of lesions located in deep brain bleeding detecting system of many batteries, including internal module and device outside.Body
Inner module is specially lesions located in deep brain device 11, device outside 12.
Wherein lesions located in deep brain device 11 is used for the ICS and parameter acquisition of invasive, is pierced by the brain for being implanted deep into intracerebral
Swash stimulus generator IPG two parts composition of electrode and thoracic implantation.Brain stimulation electrode has the stimulation contact that can be discharged,
It passes through stimulus generator IPG and provides weak electric pulse.Its implantation is general by installing the headstock, MRI or CT scan, preoperative planning,
Main to include that positioning is dissected microdot and places the design of operation needle track, scalp cuts and sphenotresia thereafter, by the electricity in art
Physiology position and art in test, be implanted into and fixed electrode, last implantable stimulation generator subcutaneous, the generally skin of clavicle lower end
Under, also it is placed on subcutaneous abdomen.Stimulus generator IPG connects lesions located in deep brain device 11 by wire through neck.
The stimulus generator IPG of thoracic implantation includes pulse generator module 23, processor module 24, first communication module
25, charge coil, at least a main battery, at least a reserve battery；Wherein processor module 24 at least includes control unit, storage part
And calculating part；Processor module controls pulse generator module according to the parameter of the stimulation of storage, and default stimulation programs
Stimulus signal is produced, and stimulus signal is sent to the contact of stimulating electrode, discharged the target area to brain deep by contact
Carry out electro photoluminescence.The control charge coil of processor module 24 charges to an at least main battery and an at least reserve battery；Processor
Module 24 controls an at least reserve battery to be charged to an at least main battery.Main battery and reserve battery be Li-Ion rechargeable battery or
Other rechargeable batteries.
Wherein lesions located in deep brain device also includes hemoglobin sensor, and whether target area can be clicked through with bleeding
Row detection.Processor module 24 carries out the control for hemoglobin sensor monitoring state open and close by control unit.Can
With the monitoring implemented real-time monitoring, opened according to certain cycle or the instant prison of the control signal for answering processor module 24
Survey.Wherein hemoglobin sensor may be selected the applicable sensor of any types, and prioritizing selection is reusable, can be grown
Time using be not required to change, the relatively simple non-damageable optical sensor of structure.As sensor can be comprising transmitting near infrared light
Miniature LED or miniature infrared transmitters, and miniature optical receiver.Light source is transmitted in hemoglobin maximum absorption wavelength
Infrared light near 540nm, its absorbance signal A is determined by the miniature optical receiver of certain distance（t）, signal is by control unit
Receive, be delivered to calculating part and calculated to determine whether there is the detection of hemoglobin.The detection meaning of hemoglobin has bleeding
The discovery of point.
The concrete behavior for judging wherein for hemoglobin can be as：In original state or confirmation without the normal of blutpunkte
Under physiological status, the signal of a period of time is gathered, calculate threshold space in normal state.In view of part it is nonlinear because
Element, a kind of algorithm of embodiment is：
After exclusion significantly interferes with signal, the maximum Amax of its signal in this section of interval is calculated, minimum value Amin and average
Value Aarg,
The maximum of threshold interval takes Amax and Amax+（（Amax-Amin）/2-Aarg）Maximum,
The minimum value of threshold interval takes Amin and Amin+（（Amax-Amin）/2-Aarg）Minimum value；
The storage part of the above-mentioned threshold value input processor module 24 of initial setting is preserved.In the prison of hemoglobin sensor
When surveying unlatching, as the A for detecting（t）Time series, there is maximum or minimum value irrelevance in threshold value more than 2*
（（Amax-Amin）/2-Aarg）, and value deviation in the same direction in the ensuing some sequences of time series has expansion to become
Gesture, when at least not less than the deviation of former trend, calculating part judges to detect the hemoglobin of abnormal amount, therefore is bleeding mould
Formula, processor module 25 sends blood early warning signal to first communication module 25 by control unit.
Wherein, in the situation for bleeding early warning do not occurred, and hemoglobin sensor reading do not occurred it is obvious
In the case of the change of trend, half a year is often spent to 1 year, it is necessary to be judged again the normality threshold of hemoglobin sensor
And calibration, to compensate the needle position misalignment of its appearance.
For determining hemoglobin or other types of sensor using other methods, if it is output as one-parameter, and
The concentration of parameter and hemoglobin then can also carry out bleeding early warning in substantially positive correlation using above-mentioned decision algorithm.
Lesions located in deep brain device can also include the cerebral sensor set near stimulating electrode.Intracranial pressure is in skull
Pressure, and be also therefore the pressure of brain tissue and cerebrospinal fluid.Cerebral sensor can be pressure sensor, such as condenser type mems
Sensor etc..Generally, the intracranial pressure of the intracranial pressure of normal person and morbid state or cephalophyma still has larger difference,
Can equally be demarcated according to initial normal pressure, be determined the threshold value P0 of normal pressure and cephalophyma pressure, when what is determined
Pressure P（t）More than threshold pressure P0 and P（t+1）To P（t+n）When being all higher than being equal to P0, it is judged to cerebral exception.Cerebral is sensed
The pressure that device will be detected is passed back to processor module 24, and the calculating part of processor module 24 is calculated and judged, if sentenced
It is set to cerebral exception, then is sent to first communication module 25.
Modes of warning for cerebral sensor is equally controlled by processor module 24, for the early warning of bleeding pattern
The early warning abnormal with cerebral can be independently unlatching, control, alarmed, it is also possible to the need for the power saving and reduce and pass
The spoilage of sensor, the pattern that cerebral is monitored of opening is sent by control unit hemoglobin postprocessor module 24 is detected；
The detection of hemoglobin sensor can also be then turned on after the abnormal judgement of cerebral is carried out.
Except non-processor sends control command, the default mode of sensor is sleep pattern.
Device outside 12 at least includes processor, second communication module 31 and warning module 32, preferably also includes man-machine
Control interface.Wherein, second communication module 31 can enter the transmitting-receiving of row information with first communication module 25, can use
The wireless communication protocols such as Zigbee, bluetooth.
The effect that device outside 12 is primarily served is to provide the early warning of abnormality, and first communication module 25 is processed in street
After the bleeding pattern early warning signal or the abnormal early warning signal of cerebral of device transmission, above- mentioned information is sent to second communication module
31, second communication module is by processor, or directly sends the signal to warning module, and early warning letter is provided to doctor or patient
Number.Early warning signal can be presented with modes such as sound, light, electricity, display screens, and two of which pattern is respectively adopted different early warning letters
Number.
Device outside 12 can also have control interface, doctor can by control interface be input into default stimulus modality,
Parameter, setting decision threshold of selection stimulation parameter, setting hemoglobin sensor and cerebral sensor etc..Processor will be above-mentioned
After control command is processed, send to second communication module 31, second communication module is transmitted to internal first communication module
31, and by above-mentioned parameter storage in processor module 24.
Additionally, device outside 12 can also be realized and computer, control centre or center treatment by second communication module 31
The bidirectional data transfers of device.Such that it is able to used central processing unit more accurate control is carried out for the system, it is also possible to for
Parameter carries out the bigger calculating of amount of calculation.With this understanding, can also may be used using the more accurate hemoglobin detection mode in part
To utilize the more brain hemodynamic parameters of measurement of intracranial pressure, to provide the physiologic information of more users.
For example, in one embodiment, blutpunkte is analyzed using image method.Hemoglobin sensor is adopted using miniature image
Acquisition means, it is not necessary to precision or resolution ratio very high.By in the data is activation after collection to microprocessor module 24, microprocessor
After module carries out or do not carry out the pretreatment such as contrast enhancing, filtering, will be sent per single-frame images information to device outside.In vitro
Device or processor meet needs to carry out the treatment of image and judges, central processing unit is further issued if being unsatisfactory for.
Processor judged according to the Color Characteristic of image, image segmentation is carried out first, then calculate the zonule after segmentation
Each color component such as RGB compositions, or the aberration for calculating is changed by YCbCr, the form and aspect for calculating is changed by HSI, is satisfied
With the color such as degree, G/R, B/G than etc. average value or the statistic such as median, the abnormal area that will be learnt before it
Color Characteristic is differentiated that its discrimination standard can be according to the difference of these characteristic quantities, with SVMs, ANN
The learners such as network carry out automatic identification its discrimination standard.Therefore, because the particular color caused by bleeding can be detected in the zone
Measure and, therefore more accurate blutpunkte can be carried out and judge.
In another implementation power, the judgement of intracranial pressure is carried out using impedance method.Intracranial pressure can be influenceed by a number of factors,
Including but not limited to cardiac cycle, the respiratory cycle and corresponding to brain blood flow body Natural regulation the slow wave cycle.Pressure
Sensor can only obtain pressure change this characteristic, but impedance reflects different features in different time scales, than
Change such as cerebral blood volume shows longer time yardstick, and the impedance variations time scale of cardiac cycle correlation is shorter.Cause
This, from impedance waveform, can reflect that many Intracranial Cerebral Blood Flows are moved among the amplitude response and time response of the impedance component of waveform
Mechanics parameter, including but not limited to intracranial pressure, cerebral blood volume, cerebral blood flow (CBF), cerebral perfusion pressure etc..Accordingly it is also possible to using it
Its sensor carries out the monitoring of intracranial pressure, especially in the case of external processor, easily can carry out dimension to parameter
More rich analysis.
In one embodiment, stimulating electrode is multiple rows of, and different brain point positions are goed deep into respectively.In another embodiment
In, stimulating electrode can be multistage, by different anatomical positions and direction, so as to be played in Single lead to multiple sites
Produce the effect of electro photoluminescence.
In one embodiment, stimulating electrode may include first section 100, stage casing 200, latter end 300 including stimulating electrode；Hand
Section, can be across apart from L between middle-end, end, its design is effectively considered to be collapsed because of magnetic resonance deviation, drift electrode, brain
Fall into, the deep brain stimulation electrode 100 that surgical head rest equal error situation exists and causes inserts the deviation that core rolls into a ball 200 position.It is first
Section, stage casing, latter end include respectively at least one set of 104,204,304 1 hemoglobin sensors 102 of electrode contacts group, 202,
302 and a cerebral sensor 103,203,303, the electrode with sensor is reaction type deep brain stimulation electrode；Electrode
Contact sets and two sensors are sealed by insulating materials respectively, can also include one I/O mouthfuls to realize data in every section
Transmission.
Every segment electrode is directed to, every group of electrode at least includes two electrode contacts, enough faces are carried out with to institute's stimulation point position
Long-pending stimulation, preferably 2-8, every group of electrode contacts are set along electrode circumferencial direction, form ring-type to ensure oneself area,
And side effect when inserting inclined is reduced, electrode contacts are connected to extended line, first section, stage casing, the electrode of latter end by conductor respectively
Contact sets are set along electrode bearing of trend.
Brain depth electrode is fed back for multisection type, is wherein set to swash in spacer unlatching bleeding detection in Single lead
Hemoglobin sensor living, is set to open cerebral sensor only in one section, to maintain battery and device in Single lead
Service life.
Claims (5)
1. the lesions located in deep brain bleeding detecting system of a kind of many batteries, it is characterised in that：The detecting system includes at least one
Lesions located in deep brain device（11）And device outside（12）, the lesions located in deep brain device（11）Including stimulating electrode（21）, it is described
Stimulating electrode（21）The hemoglobin sensor for nearby setting（22）, pulse generator module（23）, charge coil, at least one master
Battery, at least a reserve battery, processor module（24）With first communication module（25）；The device outside（12）Including second
Communication module（31）And warning module（32）；The lesions located in deep brain device（11）The processor module（24）Control is described
Pulse generator module（23）Stimulation parameter according to storage produces stimulus signal, and the stimulus signal is sent into the thorn
Swash electrode（21）Contact, by the contact discharge electro photoluminescence is carried out to target area；Meanwhile, the hemoglobin sensor
（22）It is real-time or intermittent to the sensor（22）Near zone detected, the processor module（24）Control is described
Charge coil charges to an at least main battery and an at least reserve battery；The processor module（24）Control is described
An at least reserve battery charges to an at least main battery.
2. the lesions located in deep brain bleeding detecting system of many batteries according to claim 1, it is characterised in that：The treatment
Device module（24）Judge whether to detect hemoglobin, once detect, then may the stimulating electrode（21）Place produces bleeding,
Ich signal is passed through into the first communication module（25）Transmit to the device outside（12）The second communication module
（31）, the warning module（32）Carry out bleeding pattern early warning.
3. the lesions located in deep brain bleeding detecting system of many batteries according to claim 1, it is characterised in that：The deep
Electro photoluminescence bleeding detecting system may also include the stimulating electrode（21）The cerebral sensor for nearby setting, detects hemoglobin
When, the cerebral sensor is detected to the cerebral sensor proximity region, the processor module（24）Judge detection
Cerebral whether be more than predetermined threshold value, be judged as cerebral exception more than predetermined threshold value, by cerebral abnormal signal pass through described first
Communication module（25）Transmit to the device outside（12）The second communication module（31）, the warning module（32）Carry out
Cerebral abnormal patterns early warning.
4. the lesions located in deep brain bleeding detecting system of many batteries according to claim 2, it is characterised in that：The stimulation
Electrode（21）May include first section, stage casing, latter end；First section, stage casing, latter end include at least one set of electrode contacts group, an institute respectively
State hemoglobin sensor and a cerebral sensor；Every group of electrode contacts at least include two electrode contacts；Electrode is touched
Point is connected to extended line by conductor respectively, and first section, stage casing, the electrode contacts group of latter end are set along electrode bearing of trend,
Every group of the electrode contacts are set along electrode circumferencial direction.
5. the lesions located in deep brain bleeding detecting system of many batteries according to claim 1, it is characterised in that：The main electricity
Pond and the reserve battery are Li-Ion rechargeable battery.
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| CN201611260929.3A CN106725371B (en) | 2016-12-30 | 2016-12-30 | Multi-battery deep brain electrical stimulation bleeding detection system |
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| CN201611260929.3A CN106725371B (en) | 2016-12-30 | 2016-12-30 | Multi-battery deep brain electrical stimulation bleeding detection system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI822447B (en) * | 2021-12-28 | 2023-11-11 | 財團法人工業技術研究院 | Movement monitor sensor |
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| US20050055064A1 (en) * | 2000-02-15 | 2005-03-10 | Meadows Paul M. | Open loop deep brain stimulation system for the treatment of Parkinson's Disease or other disorders |
| US9278208B1 (en) * | 2003-10-20 | 2016-03-08 | University Of Central Florida Research Foundation, Inc. | Spatial-temporal deep brain stimulation methods and systems |
| CN101116610A (en) * | 2007-09-06 | 2008-02-06 | 上海交通大学 | Gastrointestinal tract hemorrhage non-invasive monitoring system |
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| US20150100108A1 (en) * | 2013-10-04 | 2015-04-09 | Boston Scientific Neuromodulation Corporation | Implantable Medical Device with a Primary and Rechargeable Battery |
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