CN106709986A

CN106709986A - Nidus and/or organ modeling method and apparatus used for model body making

Info

Publication number: CN106709986A
Application number: CN201710144866.3A
Authority: CN
Inventors: 王薇; 薛华丹
Original assignee: Shanghai Science And Technology Intelligent Technology Co Ltd
Current assignee: Shanghai Science And Technology Intelligent Technology Co Ltd
Priority date: 2017-03-13
Filing date: 2017-03-13
Publication date: 2017-05-24
Anticipated expiration: 2037-03-13
Also published as: CN106709986B

Abstract

The invention relates to a nidus and/or organ modeling method and apparatus used for model body making. The nidus and/or organ modeling method used for model body making comprises the steps of performing three-dimensional simulation modeling of a nidus and/or an organ to generate a first modeling file of the nidus and/or the organ; performing medical image-based three-dimensional modeling of the nidus and/or the organ to generate a second modeling file of the nidus and/or the organ; and performing image registration and fusion on the first modeling file and the second modeling file to generate a third modeling file of the nidus and/or the organ. According to the method and the apparatus, nidus and/or organ modeling for model body making is realized through the registration and fusion of the three-dimensional simulation modeling and the medical image-based three-dimensional modeling.

Description

The focus and/or organ modeling method and device made for die body

Technical field

This disclosure relates to Medical Imaging Technology field, in particular to a kind of focus made for die body and/or device Official's modeling method, device and electronic equipment.

Background technology

In the market, the supply of medical science die body is technically popularized to clinic and is not all reached clinical diagnosis much and control The demand for the treatment of, such as present clinically widely used large medical equipment CT and MR.CT die bodys in the market are generally to survey Designed by examination equipment ray, mostly spherical, cylindrical water mould or single PMMA die bodys, its shape and bio-imitability and clinic should With also very big gap；And senior CT die bodys then can seldom be seen at clinical treatment center, more in Advanced Research Center Or the research and development department of large scale equipment company uses, and it is also the internal embedding density containing differential declines based on specification mechanical configurations Sample of material, be mainly used in system debug and test, it is difficult to really be embodied as clinical service.

There is presently no can precisely react human body details dissect mechanism, focus/pathological information and possess embodiment image doctor The clinical medicine die body of equipment performance is learned, less with the stability (for example, under x- ray long exposures) for talking the medical science die body Property payable with cost.

Therefore, also there is the part that has much room for improvement in technical scheme of the prior art.

It should be noted that information is only used for strengthening the reason of background of this disclosure disclosed in above-mentioned background section Solution, therefore can include not constituting the information to prior art known to persons of ordinary skill in the art.

The content of the invention

The purpose of the disclosure is to provide a kind of focus made for die body and/or organ modeling method, device and electricity Sub- equipment, and then at least overcome to a certain extent because one or more is asked caused by the limitation of correlation technique and defect Topic.

Other characteristics and advantage of the disclosure will be apparent from by following detailed description, or partially by this public affairs The practice opened and acquistion.

According to an aspect of this disclosure, there is provided a kind of focus and/or organ modeling method made for die body, bag Include：

The three-dimensional artificial modeling of the focus and/or organ is carried out, the first modeling text of the focus and/or organ is generated Part；

Carry out the three-dimensional modeling based on medical image of the focus and/or organ, generate the focus and/or organ Second modeling file；

First modeling file and second modeling file are carried out into image registration and fusion, the focus is generated And/or the 3rd modeling file of organ.

In a kind of exemplary embodiment of the disclosure, methods described also includes：

Clinical demand is set up, and analyzes the system property of the equipment for being applicable the die body；

System property according to the clinical demand and the equipment determines the 26S Proteasome Structure and Function of the die body.

In a kind of exemplary embodiment of the disclosure, the structure of the die body is according to the focus and/or the solution of organ The highest spatial resolution of characteristic and equipment needs is cutd open to determine.

In a kind of exemplary embodiment of the disclosure, the system property and institute of the function of the die body according to the equipment State the physiological function decision that focus and/or organ are completed.

In a kind of exemplary embodiment of the disclosure, methods described also includes：According to the 26S Proteasome Structure and Function of the die body Determine the composition material of the die body.

In a kind of exemplary embodiment of the disclosure, the three-dimensional artificial modeling of the focus and/or organ, generation are carried out First modeling file of the focus and/or organ includes：

System property according to the clinical demand and the equipment carries out the modeling structure ginseng of the focus and/or organ Number is set；

System property according to the clinical demand and the equipment carries out the material parameter of the composition material of the die body Set；

The material parameter generation of the composition material of modeling structure parameter and the die body according to the focus and/or organ First modeling file of the focus and/or organ.

The three-dimensional based on medical image of the focus and/or organ is carried out in a kind of exemplary embodiment of the disclosure Modeling, the second modeling file for generating the focus and/or organ includes：

Type, function and/or clinical demand according to the die body, are gathered by the first image documentation equipment and include the focus And/or dissection and first image file of function information of organ；

Image procossing and three-dimensional modeling are carried out to first image file, the second of the focus and/or organ is generated Modeling file.

In a kind of exemplary embodiment of the disclosure, image procossing and three-dimensional modeling are carried out to first image file Including：

Picture characteristics according to first image file and first image file carries out area-of-interest division；

Image segmentation and modeling are carried out to the area-of-interest so that each organ, function or focus independence shape Into a reconstruction file.

The focus and/or multiple described first image of organ out of phase phase are gathered by first image documentation equipment File；

Reconstruction file to the multiple first image file generation carries out the image of anatomical structure and phase time Registration, forms modeling file after the registration of the multiple first image file out of phase phase.

The second image text of the dissection comprising the focus and/or organ and function information is gathered by the second image documentation equipment Part；

Second image file and first image file are carried out into image registration according to anatomical features point, institute is formed State modeling file after the first image file and second image file registration.

Reconstruction file to the multiple first image file generation carries out the image of anatomical structure and phase time Registration, forms modeling file after the registration of the multiple first image file out of phase phase；

Text will be modeled after the registration of second image file and the multiple first image file out of phase phase Part carries out image registration according to anatomical features point, forms the multiple first image file and second image file is matched somebody with somebody Modeling file after standard.

According to an aspect of this disclosure, there is provided a kind of focus made for die body and/or organ model building device, bag Include：

First MBM, the three-dimensional artificial for carrying out the focus and/or organ is modeled, generate the focus and/ Or the first modeling file of organ；

Second MBM, the three-dimensional modeling based on medical image for carrying out the focus and/or organ generates institute State the second modeling file of focus and/or organ；

3rd MBM, for first modeling file and second modeling file being carried out into image registration and being melted Close, generate the 3rd modeling file of the focus and/or organ.

According to an aspect of this disclosure, there is provided a kind of electronic equipment, including：

Processor；And

Memory, the executable instruction for storing the processor；

Wherein, the processor be configured as performing described in above-mentioned any one for die body make focus and/or Organ modeling method.

The focus made for die body and/or organ modeling method, device and electronics that disclosure implementation method is provided In equipment, by modeling three-dimensional artificial and three-dimensional modeling based on medical image carries out image registration and fusion, focus is generated And/or the final modeling file of organ.The final modeling file can be applied to the making of die body, by the final modeling text The die body of part printing can precisely react human body details anatomical structure, focus and/or pathological information and embodiment medical imaging equipment Performance.

It should be appreciated that the general description of the above and detailed description hereinafter are only exemplary and explanatory, not The disclosure can be limited.

Brief description of the drawings

Accompanying drawing herein is merged in specification and constitutes the part of this specification, shows the implementation for meeting the disclosure Example, and it is used to explain the principle of the disclosure together with specification.It should be evident that drawings in the following description are only the disclosure Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis These accompanying drawings obtain other accompanying drawings.

Fig. 1 is the stream of a kind of focus made for die body and/or organ modeling method in disclosure exemplary embodiment Journey schematic diagram.

Fig. 2 is another focus made for die body and/or organ modeling method in disclosure exemplary embodiment Schematic flow sheet.

Fig. 3 is a kind of schematic flow sheet of the three-dimensional modeling based on medical image in disclosure exemplary embodiment.

Fig. 4 is the schematic diagram of another three-dimensional modeling based on medical image in disclosure exemplary embodiment.

Fig. 5 is a kind of schematic flow sheet of three-dimensional artificial modeling in disclosure exemplary embodiment.

Fig. 6 be disclosure exemplary embodiment in a kind of pancreas die body, sustainer, arteria linenalis, cavity of resorption artery and branch move The theoretical modeling schematic diagram of arteries and veins.

Fig. 7 is a kind of pancreas die body, the theoretical modeling schematic diagram of pancreas in disclosure exemplary embodiment.

Fig. 8 is a series of a kind of CT pancreas image schematic diagrames of arterial phases in disclosure exemplary embodiment.

Fig. 9 is a series of a kind of CT pancreas image schematic diagrames of vein phases in disclosure exemplary embodiment.

Figure 10 is a kind of MR pancreas image schematic diagram in disclosure exemplary embodiment.

Figure 11 be disclosure exemplary embodiment in a kind of pancreas die body, sustainer, arteria linenalis, cavity of resorption artery and branch move Arteries and veins is based on the modeling schematic diagram of the CT pancreas image arterial phases shown in Fig. 8.

Figure 12 be disclosure exemplary embodiment in a kind of pancreas die body be based on Fig. 8 shown in CT pancreas image artery phases Position, the medical image modeling based on the CT pancreas image vein phase shown in Fig. 9 and based on the MR pancreas images shown in Figure 10.

Figure 13 is a kind of image registration and each final focus of fusion generation and organ in disclosure exemplary embodiment Modeling file schematic diagram.

Figure 14 is a kind of pancreas die body schematic diagram of 3D printing in disclosure exemplary embodiment.

Figure 15 is the pancreas die body and pancreas monomer schematic diagram of a kind of 3D printing in disclosure exemplary embodiment.

Figure 16 is the side of a kind of focus made for die body and/or organ model building device in disclosure exemplary embodiment Frame schematic diagram.

Specific embodiment

Example embodiment is described more fully with referring now to accompanying drawing.However, example embodiment can be with various shapes Formula is implemented, and is not understood as limited to example set forth herein；Conversely, thesing embodiments are provided so that the disclosure will more Fully and completely, and by the design of example embodiment those skilled in the art is comprehensively conveyed to.Described feature, knot Structure or characteristic can be combined in one or more implementation methods in any suitable manner.In the following description, there is provided perhaps Many details are so as to provide fully understanding for implementation method of this disclosure.It will be appreciated, however, by one skilled in the art that can Omit one or more in the specific detail to put into practice the technical scheme of the disclosure, or other sides can be used Method, constituent element, device, step etc..In other cases, be not shown in detail or describe known solution a presumptuous guest usurps the role of the host avoiding and So that each side of the disclosure thickens.

Additionally, accompanying drawing is only the schematic illustrations of the disclosure, it is not necessarily drawn to scale.Identical accompanying drawing mark in figure Note represents same or similar part, thus will omit repetition thereof.Some block diagrams shown in accompanying drawing are work( Energy entity, not necessarily must be corresponding with physically or logically independent entity.These work(can be realized using software form Energy entity, or these functional entitys are realized in one or more hardware modules or integrated circuit, or at heterogeneous networks and/or place These functional entitys are realized in reason device device and/or microcontroller device.

At present, die body is one of main tool of measurement radiation absorption dosage and Large-scale Medical Equipment quality control, wherein Including human body simulation die body.Embodiment of the present invention combination 3D printing technique and medical imaging, to apply to clinical diagnosis and treatment Medical imaging device provide medical application die body (Medical Phantom).Here medical science die body is a kind of special doctor Image documentation equipment is learned, dedicated for detection, correction, regulation and optimization Large-size Medical Imaging Equipments (such as CT, MR, PET (positive electron Emission computed tomography), SPECT (Single-Photon Emission Computed Tomography, single photon hair Penetrate computerized tomography), MRI (Magnetic Resonance Imaging, magnetic resonance imaging) etc.) systematic parameter and Using algorithm.

Fig. 1 is the stream of a kind of focus made for die body and/or organ modeling method in disclosure exemplary embodiment Journey schematic diagram.Wherein, die body here can be above-mentioned medical science die body, but the disclosure is not limited to this.

As shown in figure 1, the focus and/or organ modeling method that are used for die body making may comprise steps of.

In the step s 100, the three-dimensional artificial modeling of the focus and/or organ is carried out, the focus and/or device is generated First modeling file of official.

In the exemplary embodiment, methods described can also include：Clinical demand is set up, and analyzes the applicable die body The system property of equipment；System property according to the clinical demand and the equipment determines the 26S Proteasome Structure and Function of the die body.

In the exemplary embodiment, being applicable the system property of the image documentation equipment of the die body can include applying the die body Image documentation equipment system performance and application parameter.For example, when CT die bodys are made, being penetrated using the x- of the CT equipment of the CT die bodys Line attenuation attribute.But the disclosure is not limited to this, the spy of its specific image documentation equipment that can be directed to according to made die body Different system property determines the 26S Proteasome Structure and Function of the die body.

In the exemplary embodiment, anatomical features and institute of the structure of the die body according to the focus and/or organ The highest spatial resolution of equipment needs is stated to determine.

In the exemplary embodiment, the function of the die body according to the system property and the focus of the equipment and/or The physiological function that organ is completed is determined.

In the exemplary embodiment, methods described can also include：Described in 26S Proteasome Structure and Function according to the die body determines The composition material of die body.

For example, when it is determined that the die body is the die body of specific spine structure and function, can select close with backbone material Degree thinks that close material-hydroxyapatite and its synthetic material make the die body of known density.But the disclosure is not limited to this.

In the exemplary embodiment, the step S100 carries out the three-dimensional artificial modeling of the focus and/or organ, generation First modeling file of the focus and/or organ can include：According to the clinical demand and the system property of the equipment Carry out the modeling structure parameter setting of the focus and/or organ；According to the clinical demand and the system property of the equipment The material parameter for carrying out the composition material of the die body is set；According to the modeling structure parameter and institute of the focus and/or organ The material parameter for stating the composition material of die body generates the first modeling file of the focus and/or organ.

In step s 110, the three-dimensional modeling based on medical image of the focus and/or organ is carried out, the disease is generated Second modeling file of stove and/or organ.

In the exemplary embodiment, the step S110 carries out based on medical image the three of the focus and/or organ Dimension modeling, the second modeling file for generating the focus and/or organ can include：Type, function according to the die body and/ Or clinical demand, dissection and the first shadow of function information comprising the focus and/or organ are gathered by the first image documentation equipment As file；Image procossing and three-dimensional modeling are carried out to first image file, generate the focus and/or organ second is built Mould file.

In the exemplary embodiment, carrying out image procossing and three-dimensional modeling to first image file can include：Root Area-of-interest division is carried out according to the picture characteristics of first image file and first image file；To described interested Region carries out image segmentation and modeling so that each organ, function or focus are individually formed a reconstruction file.

In the exemplary embodiment, carrying out image procossing and three-dimensional modeling to first image file can include：It is logical Cross first image documentation equipment and gather the focus and/or multiple described first image file of organ out of phase phase；To institute Stating the reconstruction file of multiple first image file generations carries out the image registration of anatomical structure and phase time, forms described Modeling file after the registration of multiple first image file out of phase phases.

In the exemplary embodiment, carrying out image procossing and three-dimensional modeling to first image file can include：It is logical Cross dissection and second image file of function information of the collection of the second image documentation equipment comprising the focus and/or organ；Will be described Second image file and first image file carry out image registration according to anatomical features point, form first image file With modeling file after second image file registration.

In the exemplary embodiment, carrying out image procossing and three-dimensional modeling to first image file can include：It is logical Cross first image documentation equipment and gather the focus and/or multiple described first image file of organ out of phase phase；To institute Stating the reconstruction file of multiple first image file generations carries out the image registration of anatomical structure and phase time, forms described Modeling file after the registration of multiple first image file out of phase phases；Gathered by the second image documentation equipment and include the disease The dissection of stove and/or organ and the second image file of function information；By second image file and the multiple described Modeling file carries out image registration according to anatomical features point after the registration of one image file out of phase phase, forms the multiple institute State modeling file after the first image file and second image file registration.

In the step s 120, first modeling file and second modeling file are carried out into image registration and fusion, Generate the 3rd modeling file of the focus and/or organ.

In the exemplary embodiment, methods described can also include：3rd modeling file is processed, energy is formed Enough preset format files recognized by 3D printer.For example, the preset format file is the network of triangle of 3D printer requirement Lattice file (.stl), but the disclosure is not limited to this.

In the exemplary embodiment, methods described can also include：Systematic parameter and/or institute according to the 3D printer The material property for stating composition material adjusts the preset format file.

In the exemplary embodiment, methods described can also include：According to the 3rd modeling file and the die body Composition material produces the die body using 3D printing method.

The focus and/or organ modeling method that are made for die body that embodiment of the present invention is provided, can generate can be with Precisely reaction human body details is dissected mechanism, focus/pathological information and embodies the clinical medicine die body of image documentation equipment performance, right The directive property of specific focus and/or organ is strong, and precision is high, and the die body has stability.

As shown in Fig. 2 the focus and/or organ modeling method that are used for die body making may comprise steps of.

In step s 201, clinical demand is set up.

In step S202, analysis is applicable the system property of the equipment of the die body.

In step S203, the system property according to the clinical demand and the equipment determine the die body structure and Function.

In step S204, the 26S Proteasome Structure and Function according to the die body determines the composition material of the die body.

CT die bodys on existing market are generally designed by test CT equipment rays, mostly spherical, cylindrical water mould or Single PMMA (Polymethyl Methacrylate, polymethyl methacrylate) die body, is to be sheared by machine or manual What polishing was manufactured, shape is single, and its shape and bio-imitability also have very big gap compared with clinical practice.And it is senior CT die bodys are also the internal embedding sample of material containing differential declines density based on specification mechanical configurations, are mainly used in system debug And test, it is difficult to really be embodied as clinical service.

In the embodiment of the present invention, imaging characteristic and principle based on the image documentation equipment itself for being applicable the die body, generation tool There is the simulated tissue material of particular characteristics.

For example, the image-forming principle of CT equipment is the attenuation coefficient to human tissue organ according to x- rays, i.e., x- rays are passed through Different human tissue organs are crossed, pad value is different.The related die bodys of CT are made, then needs the x- ray attenuations to material Value is measured and demarcated, and it is leveled off to the tissue and organ of analogue simulation as far as possible.For example, can be by PMMA The nano composite material that the nano molecular material of (polymethyl methacrylate) and highly attenuating value is made by a certain percentage, makes it not CT value of the nano composite material in proportion in x-ray is near line sexual intercourse.For example, it is also possible to use diodone mixing physiology Perfusion of saline in die body, for emulating imaging of the artery and vein vascular in CT.Again it is for instance possible to use polyurethane froth is emulated Lung structure.Again it is for instance possible to use epoxy resin artificial solid water etc..The disclosure is not limited to above-mentioned simulated tissue material Material.

In step S205, the three-dimensional modeling based on medical image of the focus and/or organ is carried out.

Fig. 3 is a kind of schematic flow sheet of the three-dimensional modeling based on medical image in disclosure exemplary embodiment.Such as Fig. 3 Shown, above-mentioned steps S205 may comprise steps of.

In step S2051, image and data acquisition are carried out.

First, the die body type and function and its demand for being confirmed according to clinician and image expert, for example：Die body is used for Optimization is directed to the clinical scan protocol of organa parenchymatosum, it is necessary to accurately react the anatomical structure of organa parenchymatosum, and pathology/focus is special Levy, and image documentation equipment characteristic (for example：The absorption and decay of the x- rays of CT equipment).According to the functional requirement of die body, collection The dissection of corresponding organ/focus and function information, such as CT and MR collections can accurately react comprising organ and lesion information The image file of human anatomic structure, this document includes DICOM file and uncorrected data file.It is enough in order to obtain spatial resolution Three-dimensional reconstruction image high, can use based on the image file of high-end CT, and data acquisition thickness is generally less than 0.6mm, After specific algorithm causes layer between 0.3mm-0.6mm, temporal resolution needs the cardiac cycle higher than 1/2, keeps X-y-z direction of principal axis isotropism.

In step S2052, data prediction and 2 dimension image reconstructions are carried out.

In step S2053, image preprocessing.

In step S2054,3 d image is rebuild and post processing of image.

In step S2055, the image modeling based on medical image.

In the exemplary embodiment, the treatment to image can include image preprocessing, post processing, and 2D conversion 3D figures As modeling.Based on DICOM images or uncorrected data, according to picture characteristics, the HU values and low contrast of such as CT are carried out to image Area-of-interest division, image segmentation and 3D modeling, each organ, functional block, focus are individually formed a reconstruction file.And By image registration, such as with reference to the image of same organs/focus under MR, with obtain high spatial resolution CT images according to Anatomical features point carries out registration, the function information for being become apparent from.

DICOM is digital imaging and communications in medicine, is the international standard (ISO 12052) of medical image and relevant information. What it defined that quality can meet clinical needs can be used for the Medical Image Format of data exchange.DICOM is widely used in putting Penetrate medical treatment, angiocarpy imaging and treatment for radiation-caused disease diagnostic device (X-ray, CT, nuclear magnetic resonance, ultrasound etc.), and in ophthalmology and Other medical domains such as dentistry obtain more and more deeply being widely applied.Ten hundreds of with medical imaging device, DICOM is one of most widely-installed medical information standard.

Here uncorrected data is a proper noun for medical image, for example, can refer to and directly be extracted from CT system Do not do 2 dimension reconstruction images (DICOM) it is direct from detector gather by human body decay data.

In step S2056, single focus of the generation based on medical image/organ embodies the modeling file of anatomical structure.

Fig. 4 is the schematic diagram of another three-dimensional modeling based on medical image in disclosure exemplary embodiment.The present invention Embodiment is to generate the second modeling file based on medical image DICOM file and/or uncorrected data.

Die body type, function and its demand that the embodiment of the present invention confirms according to clinician and image expert engineer, Collection clinical medicine image data, it is carried out image preprocessing, post processing, rebuild and form conversion and optimize etc. a series of shadows As treatment technology, detachable or combination the one group of network of triangle lattice file that can be recognized by 3D printer is formed.With reference to Fig. 2 is described.

First, image and data acquisition are carried out.

In one embodiment, the image that can be obtained here can be DICOM (Digital Imaging and Communications in Medicine) image.

In another embodiment, uncorrected data (raw data) can be obtained, data prediction then is carried out to the uncorrected data And image reconstruction.For example：Noise reduction, go artifact, area-of-interest selection (ROI (region of interest) info), iteration Rebuild enhancing etc..

Wherein, area-of-interest selection for example can be, the need accurate and meaningful with respect to bone density value in order that measurement Unified measuring point and measurement range are used, by operator according to the method for image procossing, measuring point is formulated with cursor Positional information on image, and this information is recorded, this has just reached the purpose of unified measurement scope.

Secondly, image and data to above-mentioned collection carry out image procossing.

In the embodiment shown in fig. 4, described image treatment can include image preprocessing.For example：Image registration, sense are emerging Interesting region enhancing, bone is extracted, muscle is extracted, image artifacts are eliminated etc..

With continued reference to Fig. 4, described image treatment can also include：Post processing of image.For example：Image divides, filtering, expands Dissipate, quantify, conversion etc..

With continued reference to Fig. 4, described image treatment can also include：Image modeling.For example：Cutting, filtering, mark etc..

Wherein, image modeling here can use three-dimensional image reconstruction and display：It is right using classical three-dimensional reconstruction algorithm The sequence image of acquisition carries out three-dimensional reconstruction on computers；And show each tomography in die body data using visualization technique View data, while including cutting, zoomed image processing function, realizes the more interaction process to image.

By the iterative process to above-mentioned image procossing, and ensure image/mould through image expert engineer and clinician Body is accurately presented organ and lesion information, generates 3D printing file.

In step S206, the three-dimensional artificial modeling of the focus and/or organ is carried out.

Fig. 5 is a kind of schematic flow sheet of three-dimensional artificial modeling in disclosure exemplary embodiment.As shown in figure 5, above-mentioned Step S206 may comprise steps of.

In step S2061, single/multiple focus 3D modeling structural parameters are set.

In step S2062, the 3D modeling structural parameters of Functional tissue are set.

In the embodiment of the present invention, according to clinical demand and image documentation equipment attribute, Theoretical Design die body proto file, die body is needed The focus and the 3D modeling structural parameters of organ to be embodied.Here modeling is mainly for final modeling provides a benchmark knot Structure standard and data.

In step S2063, the 3D modeling material parameter of single/multiple focuses is set.

In step S2064, the 3D modeling material parameter of Functional tissue is set.

In the embodiment of the present invention, according to clinical demand and image documentation equipment attribute, die body material parameter, e.g., CT die bodys are designed Mainly the x- attenuation coefficients of designing material and the ray ageing resistance of material and different power spectrums irradiation under class line Property change curve.

In step S2065, system property of the generation based on equipment (can for example include device systems feature and application ginseng Number) focus and/or organ three-dimensional artificial modeling file.

Based on the prototype modeling of step S2061-S2064 generation die bodys, modeling parameters include dimensional structure parameter and material Figure parameters.

In step S207, the three-dimensional of three-dimensional modeling and step S206 according to above-mentioned steps S205 based on medical image Simulation modeling, carries out image registration and fusion.

Wherein, the die body modeling file that the die body modeling file and medical image of theoretical informatics are formed is carried out into image registration And fusion, generate the modeling file of final each focus and organ.

In the embodiment of the present invention, three-dimensional is passed through based on clinical demand and using the system property of the image documentation equipment of the die body Simulation modeling can set up a simulation model, then the modeling that this simulation model and medical image are formed is carried out into image registration And fusion, then it imported into again in 3D printer and is printed.

In step S208, carry out structural parameters adjustment, optimization or standardize.

In step S209, carry out material parameter adjustment, optimization or standardize.

The three-dimensional reconstruction file and theoretical modeling file formed by DICOM merge registration later, it is necessary to be converted into triangle Shape grid file (.stl) can just be recognized by 3D printer.Stl file is the normative document class that rapid prototyping system is applied Type, it is made up of the face closed or body.The modeling file of each focus and organ is converted into triangular mesh one by one File, it is necessary to eliminate conversion in formed deterioration in accuracy and format conversion to model influence, for example can be by adjusting grid The quantity and size of file, printing precision is ensured by the method for interpolation.In addition it is also necessary to " will be not turned off " or " opening " text Part is repaired and filled, because the file of " being not turned off " or " opening " will not be received by printer, must be adopted File repairing, the method that can for example increase using the method for multiple interpolation or border are carried out with post processing.Avoid this simultaneously Influence of the step of post processing to primitive modeling, i.e., in post processing of image so that final treatment modeling passes through shadow with original As equipment system property produce modeling between deviation it is default at one within the scope of.

In step S210, generate single focus/organ can 3D printing modeling file.

In step S211, the integration and configuration of single modeling file are carried out.

In the exemplary embodiment, different 3D printers is due to the difference of printing type, to network of triangle lattice file It is required that also different, for example, minimum dimension, minimum wall thickness (MINI W.), minimal tilt degree etc., the network of triangle lattice file for ultimately forming, it is necessary to Systematic parameter and the material property of the composition material of the die body further according to the 3D printer for using is adjusted.Its In, due to the density based on material, soft durometer, pool time etc., the printable minimum dimension of different materials, minimum wall thickness (MINI W.), Gradient etc. is all different, thus it is different according to the actual material for using, set these basic parameters.

For example, with photosensitive resin material, minimum dimension can reach 0.016mm, but use rubber-like materials, minimum dimension 1mm is only, wall thickness is more than 1mm.

In step S212, the standardization that die body models clinical parameter is carried out.

Clinical parameter standardization, matched curve generation, as a table of comparisons are carried out to die body structural parameters, material parameter Clinical practice is provided.Such as, the physical dimension table of comparisons per one scan interface, is imaged HU value comparison tables under different power spectrums.Certainly, it is right The outward appearance and color of die body can also carry out unified regulation, for example, blue vein, red artery, the translucent color table of body of gland Show, but the disclosure is not limited to this.

In the exemplary embodiment, the standardization to the clinical parameter of the die body includes：By the outward appearance table of the die body Levy standardization.

In the exemplary embodiment, the outward appearance signature criteria of the die body is included：To corresponding organ and/or focus Carry out the regulation of different colours.

Wherein, the outward appearance signature criteria of the die body, can be accustomed to according to medical science, and corresponding organ/focus is carried out Color assignment, for example, sustainer is characterized as red, vein is characterized as blueness, and body of gland is characterized as green, and peripheral tissues are characterized as Light colour or edematus etc..But the disclosure is not limited to this.

In the exemplary embodiment, methods described also includes：Standardization to the functional characteristic of the die body.

In the exemplary embodiment, the standardization to the functional characteristic of the die body includes：According to the image documentation equipment Imaging characteristic, different organs and/or focus are characterized using different printed materials or addition biomimetic material.

Wherein, the functional characteristic standardization of the die body, according to the system property of image documentation equipment, different organ/focuses Its expression characteristics under the imaging of specific image documentation equipment is identified using different printed materials or addition biomimetic material.

For example, in CT imagings, (according to the power spectrum of x- generators, the material and thickness of the pass filter for passing through have very HU values Big difference, only illustrates here), squeeze into the blood vessel imaging feature 400-600HU of contrast agent, then for printing vascular wall The CT values of printed material or addition biomimetic material with internal blood should also within the scope of 400-600HU；Substantive device Official's such as liver, pancreas, spleen, CT values are between 100-300HU, then for print and characterize parenchymal viscera material or The CT values of person's biomimetic material also should be in this interval and certain according to the different presentations of power spectrum of different x- generators (according to the difference of power spectrum, HU values change, while spatial resolution changes, specifically need to draw power spectrum for rule change Change curve between curve and biomimetic material)；The CT values of bone are general between 400-1200HU, relatively different function and Anatomical position is different, then the CT values for printing and characterizing bone material or biomimetic material should also fall in this area It is interior.Wherein realize that the CT values control of printed material or addition biomimetic material, can be with nano combined within preset range Material controls HU scopes.

Above-mentioned pass filter is the device for changing image source characteristic that image documentation equipment is carried, for example, CT system has aluminium The pass filter of matter, by this pass filter, the power spectrum of x- rays there occurs change, so that the imaging degradation of organ can also become Change.

3D printing file based on above-mentioned generation, carries out the 3D printing of die body.

3D printing treatment and the selection of printed material can first be carried out.For example：The treatment of light-sensitive material, hybrid digital resin Material, density of material regulation, color instruction etc..

Then, 3D printing is carried out.For example：Print system optimization system is adjusted, die body rigidity hardness regulation etc..

In the exemplary embodiment, the 26S Proteasome Structure and Function demand according to die body itself, to the selection of each modeling file not Printed material together (each modeling file is required for the selection of material, and can select equally can also be different, as long as according to The focus and organ of clinical demand and modeling file mark).For example, single curable liquid photosensitive resin, numeral mixes ultraviolet Photocuring photosensitive resin, class rubber photosensitive resin, transparent photosensitive resin, monochromatic rigidity it is opaque opaque with band colour or Translucent photosensitive resin, the combination of these miscibility liquid photosensitive resins can reach thousands of kinds of digital materials.These materials Density it is different with color, can refer and synthesize also different with other materials, can indicate to x- ray attenuations characteristic from structure, color Different focuses and organ.Using this many compositions (i.e. digital material it is unlimited can mixed type, for example, the pigment of oil painting is mixed Close), not only, for example, color, shape, soft durometer etc. react real organ and lesion information, can may be used also from external feature So that in the functionally density of such as material, to the absorptivity and attenuation characteristic of x- rays, embodiment is applicable the image of the die body The self-characteristic and parameter of equipment.

Using selected simulated human tissue material as each modeling file printed material, using the simulation people Body organization material carries out the printing of the anatomical structure of the focus and/or organ, for example can be by the side such as incorporating, irrigating, sinter Method.

In the exemplary embodiment, methods described can also include：System school is carried out to the equipment using the die body Accurate and/or Verification.

The medical science die body of generation is put into image documentation equipment and is verified and is tested, list Deviation of equipments correction chart and specific Change curve is fitted, in case routine use and system calibration.The functional characteristic of die body, can show in data form, for example, For CT equipment, under the condition of scanning：Voltage 120kV, electric current 300mA, wherein pass filter 10mm aluminium, bone, substantial viscera, flesh The CT values scope of meat, blood vessel, lung brain etc. can be indicated respectively, be used for calibrating and demarcating image in this, as a clinical criteria setting It is standby, it is possible to selection and optimization clinical scan protocol.

Be used for the manufacturing process of pancreas die body that CT equipment is used below by one, function be for adjusting device most The setting of good clinical scanning parameter is illustrated to the above method.

According to clinical demand, pancreas die body include hydrops in tumour, tumour are formed in pancreas, pancreas main pancreatic duct expansion, Tumour, arteria linenalis, splenic vein, cavity of resorption be dynamic/the arteriovenous involvement that causes of vein and tumour and position relationship.

According to the characteristic of CT equipment, die body needs to embody the x- ray attenuations attribute and guarantee material of above-mentioned focus and organ Ray ageing resistance and the class linear change characteristic under the irradiation of different power spectrums, and ensure in each modeling file structure and The continuity of size, seamlessly transits, and in the accurate derivation property of each plane of scanning motion, deviation cannot be more than the sky of CT equipment Between resolution ratio maximum.

The three-dimensional artificial modeling of focus and organ is carried out first, according to the arteriovenous size and trend of human body, pancreatic body Surface characteristics carries out theoretical modeling, and selects printable material parameter.Fig. 6 is a kind of pancreas in disclosure exemplary embodiment The theoretical modeling schematic diagram of die body, sustainer, arteria linenalis, cavity of resorption artery and bifurcated artery.

Fig. 7 is a kind of pancreas die body, the theoretical modeling schematic diagram of pancreas in disclosure exemplary embodiment.As shown in fig. 7, Including head of pancreas, body of pancreas and tail of pancreas.

Then the 3-dimensional based on medical image is carried out to model.First, data acquisition can gather the CT image arterial phase phases and Two groups of data of vein phase phase, wherein arterial phase phase include pancreatic body, sustainer, arteria linenalis and other artery information, and Substantially, hydrops information is obvious in main pancreatic duct for tumor boundaries；The vein phase phase includes cardinal vein, and splenic vein also has other veins to believe Breath, tumour information is obvious.Meanwhile, because pancreas belongs to video imaging boundary information of the substantial viscera in CT not substantially, it is necessary to borrow The information for helping MR nuclear magnetic resonance to present does auxiliary reference.So can carry out image registration and divide using three group images altogether here Cut, finally give the 3-dimensional modeling of medical image.But the disclosure is not limited to this, in other embodiments, it is also possible to only with CT image arterial phases issue evidence or CT image vein phases issue are modeled according to the 3-dimensional for carrying out medical image, or can also Using CT images arterial phase issue evidence and CT image vein phases issue according to image registration and segmentation is carried out, medical image is obtained 3-dimensional modeling.

Fig. 8 is a series of a kind of CT pancreas image schematic diagrames of arterial phases in disclosure exemplary embodiment.Such as Fig. 8 institutes Show, in the CT images of this series of artery behavior, pancreas, artery information are visible.

Fig. 9 is a series of a kind of CT pancreas image schematic diagrames of vein phases in disclosure exemplary embodiment.Such as Fig. 9 institutes Show, pancreas, vein, tumour hydrops, tumour information are visible in the CT images of this series of vein behavior.

Figure 10 is a kind of MR pancreas image schematic diagram in disclosure exemplary embodiment.As shown in Figure 10, in the MR images, Main pancreatic duct tumour hydrops information is visible.

Figure 12 be disclosure exemplary embodiment in a kind of pancreas die body be based on Fig. 8 shown in CT pancreas image artery phases Position, the medical image modeling based on the CT pancreas image vein phase shown in Fig. 9 and based on the MR pancreas images shown in Figure 10.Such as Shown in Figure 12, the medical image that should be based on CT images arterial phase, vein phase and MR images is modeled, including sustainer, spleen are dynamic Arteries and veins and bifurcated artery, cardinal vein, splenic vein and branch vein, tumour, pancreatic neoplasm, hydrops in main pancreatic duct.

Then image co-registration and registration are carried out.The die body that the die body modeling file and medical image of theoretical informatics are formed is built Mould file carries out the modeling file of image registration and fusion, each final focus of generation and organ.

Figure 13 is a kind of image registration and each final focus of fusion generation and organ in disclosure exemplary embodiment Modeling file schematic diagram.As shown in figure 13, it is the mould for forming the die body modeling file and medical image of theoretical informatics After volume modeling file carries out image registration and fusion, the modeling file of each final focus of generation and organ.

In the exemplary embodiment, with reference to 3D printing technique and Medical Imaging Technology, using medical image DICOM rebuild and Medical science DICOM is rebuild file and changed by post-processing technology, the information of real reaction member/focus with image conversion techniques Into the acceptable network of triangle lattice file of 3D printer (for example：.stl), the imaging characteristic of integrative medicine image documentation equipment is (for example： X- radiation absorptions and attenuation characteristic), with high-resolution (for example：0.016mm) 3D printing technique is made and is reappeared with physical form Organ/lesion information, the medical science die body of the anatomical structure of accurate reaction human body, confirms and optimizes for clinical scan protocol, The system of larger medical image documentation equipment and parameter adjustment, and auxiliary generate new test stone and the association of medical imaging device View.

In the embodiment of the present invention using the high resolution printed technologies of 3D combine it is advanced can present image documentation equipment attribute and The simulated human tissue material of parameter, can provide the die body of each position of simulation human body, various internal organs completely for clinic.Especially It is that for magnetic resonance, or identical die body close with real human body amount containing Hydrogen Proton, form can be produced, can is to face Bed solves this problem.Facility can not only be provided for clinical treatment work, more can be the specialty such as irradiation image technology, diagnosis Teaching provides the possibility of simulation teching, and the application prospect in future is excellent.

Figure 15 is the pancreas die body and pancreas monomer schematic diagram of a kind of 3D printing in disclosure exemplary embodiment.Such as Figure 15 It is shown, the pancreas die body and pancreas monomer including arteriovenous, tumor information of the 3D printing.

Embodiment of the present invention combination 3D printing technique and medical imaging, to apply to the medical image of clinical diagnosis and treatment Equipment provides medical application die body (Medical Phantom).Medical science die body is a kind of special medical imaging device, special to use In detection, correction, regulation and optimization Large-size Medical Imaging Equipments (such as CT, MR, PET etc.) systematic parameter and apply algorithm.

Using the modeling method in the embodiment of the present invention, on the one hand, precisely reaction human body details dissecting machine can be produced Structure, focus/pathological information and embodies the clinical medicine die body of medical imaging equipment performance.On the other hand, the mould produced Body has stability and the payable property of cost.Open the emulation modelling method that a kind of brand-new method makes medical die body.No Only precision is high, while strong to certain organs/focus directive property.

As shown in figure 16, the focus and/or organ model building device 10 that are used for die body making can include the first modeling mould Block 100, the second MBM 110 and the 3rd MBM 120.

Wherein, the first MBM 100 can be used for carrying out the three-dimensional artificial modeling of the focus and/or organ, generation First modeling file of the focus and/or organ.

Second MBM 110 can be used for carrying out the three-dimensional modeling based on medical image of the focus and/or organ, Generate the second modeling file of the focus and/or organ.

3rd MBM 120 can be used for for first modeling file and second modeling file carrying out image matching somebody with somebody Accurate and fusion, generates the 3rd modeling file of the focus and/or organ.

The detail of each module/unit exists in the above-mentioned focus made for die body and/or organ model building device It is described in detail in corresponding focus and/or organ modeling method for die body making, therefore here is omitted.

Further, embodiment of the present invention also provides a kind of electronic equipment, can include：Processor；And memory, Executable instruction for storing the processor.

Wherein, the processor is configured as performing the focus made for die body described in above-mentioned any embodiment And/or organ modeling method.

In the exemplary embodiment, a kind of non-transitorycomputer readable storage medium including instructing, example are additionally provided Such as include the memory of instruction, above-mentioned instruction can be upper with complete in the exemplary embodiment by the computing device of electronic equipment State technical scheme.For example, the non-transitorycomputer readable storage medium can be ROM, random access memory (RAM), CD-ROM, tape, floppy disk and optical data storage devices etc..

Although it should be noted that being referred to some modules of the device/equipment for action executing in above-detailed Or unit, but this division is not enforceable.In fact, according to embodiment of the present disclosure, above-described two Or more the feature and function of module or unit can be embodied in a module or unit.Conversely, above-described The feature and function of one module or unit can be further divided into being embodied by multiple modules or unit.

Additionally, although each step of method in the disclosure is described with particular order in the accompanying drawings, this does not really want Asking or imply must perform these steps according to the particular order, or the step having to carry out shown in whole could be realized Desired result.It is additional or alternative, it is convenient to omit some steps, multiple steps are merged into a step and is performed, and/ Or a step is decomposed into execution of multiple steps etc..

Those skilled in the art will readily occur to its of the disclosure after considering specification and putting into practice invention disclosed herein Its embodiment.The application is intended to any modification, purposes or the adaptations of the disclosure, these modifications, purposes or Person's adaptations follow the general principle of the disclosure and including the undocumented common knowledge in the art of the disclosure Or conventional techniques.Description and embodiments are considered only as exemplary, and the true scope of the disclosure and spirit are by appended Claim is pointed out.

Claims

1. it is a kind of for die body make focus and/or organ modeling method, it is characterised in that including：

The three-dimensional artificial modeling of the focus and/or organ is carried out, the first modeling file of the focus and/or organ is generated；

The three-dimensional modeling based on medical image of the focus and/or organ is carried out, the second of the focus and/or organ is generated Modeling file；

First modeling file and second modeling file are carried out into image registration and fusion, generate the focus and/or 3rd modeling text of organ.

2. it is according to claim 1 for die body make focus and/or organ modeling method, it is characterised in that it is described Method also includes：

3. it is according to claim 2 for die body make focus and/or organ modeling method, it is characterised in that it is described The structure of die body is determined according to the highest spatial resolution that the anatomical features and the equipment of the focus and/or organ need It is fixed.

4. it is according to claim 2 for die body make focus and/or organ modeling method, it is characterised in that it is described The function of die body is determined according to the physiological function that the system property and the focus and/or organ of the equipment are completed.

5. it is according to claim 2 for die body make focus and/or organ modeling method, it is characterised in that it is described Method also includes：26S Proteasome Structure and Function according to the die body determines the composition material of the die body.

6. it is according to claim 5 for die body make focus and/or organ modeling method, it is characterised in that carry out The three-dimensional artificial modeling of the focus and/or organ, the first modeling file for generating the focus and/or organ includes：

System property according to the clinical demand and the equipment carries out the focus and/or the modeling structure parameter of organ sets Put；

The material parameter that system property according to the clinical demand and the equipment carries out the composition material of the die body is set；

Described in the material parameter generation of the composition material of modeling structure parameter and the die body according to the focus and/or organ First modeling file of focus and/or organ.

7. it is according to claim 1 for die body make focus and/or organ modeling method, it is characterised in that carry out The three-dimensional modeling based on medical image of the focus and/or organ, generates the second modeling file of the focus and/or organ Including：

Type, function and/or clinical demand according to the die body, by the first image documentation equipment gather comprising the focus and/ Or dissection and first image file of function information of organ；

Image procossing and three-dimensional modeling are carried out to first image file, the second modeling of the focus and/or organ is generated File.

8. it is according to claim 7 for die body make focus and/or organ modeling method, it is characterised in that to institute Stating the first image file and carrying out image procossing and three-dimensional modeling includes：

Image segmentation and modeling are carried out to the area-of-interest so that each organ, function or focus are individually formed one Individual reconstruction file.

9. it is according to claim 7 for die body make focus and/or organ modeling method, it is characterised in that to institute Stating the first image file and carrying out image procossing and three-dimensional modeling includes：

The focus and/or multiple described first image of organ out of phase phase text are gathered by first image documentation equipment Part；

Reconstruction file to the multiple first image file generation carries out the image registration of anatomical structure and phase time, Form modeling file after the registration of the multiple first image file out of phase phase.

10. it is according to claim 7 for die body make focus and/or organ modeling method, it is characterised in that to institute Stating the first image file and carrying out image procossing and three-dimensional modeling includes：

Dissection and the second image file of function information comprising the focus and/or organ are gathered by the second image documentation equipment；

Second image file and first image file are carried out into image registration according to anatomical features point, described the is formed Modeling file after one image file and second image file registration.

11. focuses and/or organ modeling method made for die body according to claim 7, it is characterised in that to institute Stating the first image file and carrying out image procossing and three-dimensional modeling includes：

Reconstruction file to the multiple first image file generation carries out the image registration of anatomical structure and phase time, Form modeling file after the registration of the multiple first image file out of phase phase；

By modeling file root after the registration of second image file and the multiple first image file out of phase phase Image registration is carried out according to anatomical features point, after forming the multiple first image file and second image file registration Modeling file.

A kind of 12. focuses made for die body and/or organ model building device, it is characterised in that including：

First MBM, the three-dimensional artificial for carrying out the focus and/or organ is modeled, and generates the focus and/or device First modeling file of official；

Second MBM, the three-dimensional modeling based on medical image for carrying out the focus and/or organ generates the disease Second modeling file of stove and/or organ；

3rd MBM, for first modeling file and second modeling file to be carried out into image registration and fusion, Generate the 3rd modeling file of the focus and/or organ.

13. a kind of electronic equipment, it is characterised in that including：

Processor；And

Memory, the executable instruction for storing the processor；

Wherein, the processor is configured as performing in the claims 1-11 being made for die body described in any one Focus and/or organ modeling method.