CN106702240B - A kind of Medical tantalum copper alloy and its preparation with antibacterial functions - Google Patents
A kind of Medical tantalum copper alloy and its preparation with antibacterial functions Download PDFInfo
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Abstract
The present invention provides a kind of new medical antibacterial tantalum copper (Ta-Cu) alloys and preparation method thereof, and chemical component is weight percentage: copper (Cu): 5-20%, and surplus is tantalum (Ta).The present invention prepares Medical tantalum copper alloy using the method for hot isostatic pressing, and the preparation technology parameter by optimization can obtain the tantalum copper alloy with excellent mechanical property and antibacterial functions.Gained Medical tantalum copper alloy has unique antibacterial functions, the bacterium infection risk caused in the use of tantalum-base alloy implanted medical device in existing medical technology can be significantly reduced, it is mainly used for suture bone, tendon, fascia and tooth to fix, or the suture for internal organ operation, it is also widely applied to each eka-tantalum copper alloy implanted medical device used in the clinical medicines fields such as orthopaedics, the department of stomatology, angiocarpy bracket intervention.
Description
Technical field
The invention belongs to technical field of biological materials, and especially suitable for medical metal material field, specially one kind has
The Medical tantalum copper alloy of antibacterial functions and its preparation.
Background technique
Metal tantalum has caused to give birth to its excellent chemical stability, excellent biological characteristics and unique structural property
The extensive concern of object medical field.Compared with existing medical metal material, tantalum mainly has both sides clear superiority: (1) tantalum has
There are more excellent chemical stability and a corrosion resisting property, under room temperature, chemistry does not occur for tantalum and hydrochloric acid, concentrated nitric acid even " chloroazotic acid "
Reaction, general inorganic salts are to tantalum without corrosiveness；(2) biocompatibility of tantalum is splendid, after being implanted into a period of time, biology
Tissue is easily grown on tantalum surface, so tantalum has the title of " close biological metal " again.The many advantages of metal tantalum are that it leads in medical treatment
The application in domain provides wide development space.Metal tantalum has following application in the medical field at present: due to the ductility of tantalum
It is good, it can be made into the filament quite even more thin with hairline.Tantalum wire as operation suture thread have sterilizing is simple, stimulation is smaller,
The advantages that tension stress is big is mainly used for suture bone, tendon, fascia and tooth and fixes, or for the suture of internal organ operation.
However, as medical metal material is more and more widely used, bring a series of problems therewith, including with medical
Centered on metal material implantation the postoperative infection (BCI) that causes more and more frequently, have become one of clinical treatment it is important
Urgent problem to be solved.The World Health Organization publication statistics indicate that, 14,000,000 people are had more than in annual hospital and are being endured to the fullest extent carefully
The brings such as the inflammation of bacterium infection-induced pain, wherein 60% bacterium infection is related with the use of implantation material.In field of orthopaedics,
Bacterium infection incidence under the premise of sterile working and systemic prophylaxis anti-inflammatory treatment, after first time replacement of total hip
The infection rate of the internal prosthesis replacement of a large amount of bone defects is outside 5-35%, the row of 2-30% after 0.5-3.0%, tumor resection
There are postoperative infections for the case of fixed stent procedure.Statistical data shows: staphylococcus epidermis and staphylococcus aureus are
Cause the main bacteria of orthopaedics implantation instrument infection, ratio is respectively 34% and 32%, other coccus ratios 13%.Therefore, it cures
One of an important factor for having become its development of restriction with the bacterium infection that metal material causes.In addition, good bio-compatible
Property is also one of prerequisite performance of medical metal material.Biocompatibility refers to that life body tissue is aitiogenic to material
A kind of performance, including histocompatbility and blood compatibility.Good biocompatibility is the primary requirement to implant material.
The biocompatibility of material includes histocompatbility and blood compatibility, is the problem of evaluation novel biomaterial must be taken into consideration.
Therefore, the deficiencies in the prior art are: there is presently no itself to have bacterial-infection resisting, and has both superior bio phase
The medical metal implanted material of capacitive.
Summary of the invention
The present invention is in view of the above-mentioned problems, propose a kind of novel doctor of antibacterial functions with excellent bio-compatible performance
With tantalum copper alloy, to solve the problems, such as that existing metal implant material itself does not have bacterial-infection resisting function.
To achieve the above object, the technical solution adopted by the present invention is that: suitable copper is added in Medical tantalum metal
(Cu), chemical component is weight percentage: copper (Cu): 5-20%, and surplus is tantalum (Ta).Other impurity elements contain in the alloy
Amount should meet the corresponding requirements in medical tantalum-base alloy national standard.Wherein the weight percent of Cu element is preferred are as follows: Cu:10-
15%.The alloy has significant anti-microbial property, and has both excellent biocompatibility, is not only expected to reduce tantalum metal implanting device
The infection rate of part surrounding tissue in clinical use, moreover it is possible to the biocompatibility of tissue Yu tantalum metal device is significantly improved,
And then improve the medical functions and success rate of tantalum metal implant devices.
In the ingredient design of the Medical tantalum copper alloy with antibacterial functions of the invention, Cu is Medical tantalum of the present invention
Most important alloying element in copper alloy, this be guarantee tantalum copper alloy there are antibacterial functions and have both superior bio compatibility must
Want one of condition and main innovation point of the invention.The present invention is that suitable copper is added in Medical tantalum metal, to protect
Demonstrate,proving micro copper ion can discharge from tantalum alloy surface endurance, to assign tantalum metal antibacterial function.If copper content is relatively
Low, tantalum alloy cannot discharge enough copper ions, can reduce the antibacterial functions of tantalum alloy.It, can if copper content is relatively excessively high
Cause tantalum alloy to discharge excessive copper ion, and then influences the corrosion resisting property and biological safety of tantalum alloy, excessively high copper content
Mechanical property and processing performance to tantalum alloy can also have a negative impact.Only in the range of Cu content provided by the invention
Interior, tantalum copper alloy could guarantee excellent anti-microbial property and bio-compatible performance simultaneously.
The present invention also provides the preparation methods of the Medical tantalum copper alloy, it is characterised in that: preparation process includes mixed
Two steps of powder and hip moulding.
Mixed powder: raw material powder is put into mixed by the pure tantalum powder and fine copper powder for being respectively less than 200 μm using average particle size as raw material
Material machine carries out dry-type mechanical mixing 20-30 hours.
Hip moulding: by forming equipped with being wrapped in hot isostatic press for alloy powder for Vacuum Package, heat etc. is quiet
Pressure technological parameter preferred scope is 1200 DEG C -1400 DEG C/200MPa-300MPa/4h-10h, at high temperature using each to impartial
Static pressure is suppressed the tantalum copper alloy densified.
Tantalum copper alloy can not be prepared using traditional fire metallurgy process, there are larger difficulties for process.Reason is metal tantalum
Fusing point be 3020 DEG C, and the boiling point of copper be 2563 DEG C, with pyrometallurgic methods smelt tantalum copper alloy when easily cause metal
The gasification of copper is volatilized, and be difficult to control copper in tantalum alloy receives rate and ingredient, and the present invention prepares tool using the method for powder metallurgy
There is the Medical tantalum copper alloy of antibacterial functions.Hot isostatic pressing method is the preparation side that a kind of preferred powder metallurgy prepares tantalum copper alloy
Method, and this method relates to preparation parameter such as sintering temperature, soaking time, the optimization process of sintering pressure etc..For example, sintering temperature
It spends low, is then possible to that material density is caused to reduce, in turn results in the problem of material mechanical performance and corrosion resisting property deficiency,
Sintering temperature is excessively high, and low melting point copper-rich phase in tantalum alloy can also be made to liquefy, the serious mechanical property and corrosion resistance for destroying material
Energy.Meanwhile soaking time is less and sintering pressure is too low, and the porosity of tantalum copper alloy can be made to increase, density reduces, thus
The service performance of material is influenced, soaking time is too long and sintering pressure is larger, can't greatly improve the correlated performance of material, together
When also will increase the technical requirements and preparation cost of equipment.Therefore, it is only prepared in suitable hot isostatic pressing provided by the invention
In the range of technological parameter, Medical tantalum copper alloy can just guarantee enough mechanical properties and corrosion resisting property, and then could sufficiently send out
Wave its antibacterial functions.
It is solid that Medical tantalum copper alloy of the present invention with antibacterial functions is mainly used for suture bone, tendon, fascia and tooth
It is fixed, or for the suture of internal organ operation, it is also widely applied to the clinical medicines necks such as orthopaedics, the department of stomatology, angiocarpy bracket intervention
Each eka-tantalum copper alloy implanted medical device used in domain.
The beneficial effects of the present invention are:
1, the present invention is by the optimization of heat and other static pressuring processes parameter in powder metallurgy, prepare mechanical property, corrosion resisting property,
The new medical tantalum copper alloy of excellent antibacterial performance.
2, when Medical tantalum copper alloy of the present invention is as implantation material, can into its tissue around sustained release micro Cu member
Element, can not only be anti-infective, moreover it is possible to effectively improve bio-compatible performance, can be widely applied to orthopaedics, the department of stomatology, cardiovascular branch
Each eka-tantalum metal implanted medical device used in the clinical medicines such as frame field.
Specific embodiment
Chemical composition ranges set by tantalum copper alloy according to the present invention, using the process of preparing of powder metallurgy, system
For embodiment 1-9 out and each 1 kilogram of comparative example 1-7 tantalum copper alloy, the chemistry of the tantalum copper alloy of embodiment 1-9 and comparative example 1-7
Compositional data is shown in Table 1.
The chemical component (weight %) of 1 embodiment and comparative example tantalum copper alloy of table
Process of preparing includes the following steps:
(1) mixed raw material: the pure tantalum powder and fine copper powder for being 45 μm using average particle size is raw materials, and every group according to table 1
Alloy composition proportion at gross mass be 1kg raw material powder, by raw material powder be put into batch mixer carry out dry-type mechanical mix
It closes 25 hours.
(2) hip moulding: the pure Ta jacket equipped with alloy powder of Vacuum Package is put into hot isostatic press, heat
Isostatic pressing process parameter is as shown in table 2.
2 heat and other static pressuring processes parameter designing of table
The tantalum copper alloy densified is suppressed to impartial static pressure using each at high temperature.It is burnt through hot isostatic pressing
Sample after knot is processed into Mechanics Performance Testing and biology performance test sample, and relevant test method and result are as follows:
One, tantalum copper alloy Mechanics Performance Testing
Tantalum copper alloy idiosome after hot isostatic pressing is taken out, each obtained tantalum copper alloy idiosome of example is arranged using Archimedes
Water law measures the bulk density of idiosome, and the results are shown in Table 3.The method for taking part tantalum copper alloy wire cutting, which is processed, to be sampled and marks
Note cuts 10mm × 10mm × 2mm specification sample, and hardness test and antibacterial experiment are carried out after sanding and polishing, uses HVS-
1000 micro Vickers measure sample hardness, and load 1.96N protects lotus time 20S, and the results are shown in Table 3 for Determination of Hardness.It presses
National standard is processed into pole shape tensile sample, tension test is carried out in MTS810 Material Testing Machine, the results are shown in Table 3.
The mechanical property of 3 embodiment and comparative example tantalum copper alloy of table
As known from Table 3, when hot isostatic pressing prepares technological parameter all in setting range of the invention, embodiment 1-9 tantalum
Copper alloy all has high-compactness and excellent mechanical property.When hot isostatic pressing prepares technological parameter, at least one is unsatisfactory for this
When the setting range of invention, tantalum copper alloy consistency is low, poor mechanical property, is unsatisfactory for the service performance of material.As comparative example 1 is burnt
Junction temperature is too low, causes the consistency of tantalum copper alloy to reduce, intensity and elongation percentage index is caused to be below embodiment tantalum copper alloy.
Comparative example 2 and 4 can make the hole of tantalum copper alloy because soaking time is less in preparation technology parameter and sintering pressure is too low
Gap rate increases, and density reduces, and the mechanical property deficiency for eventually leading to tantalum copper alloy influences the applicable performance of material.Comparative example 3 is then
Since sintering temperature is excessively high, the liquefaction of low melting point copper-rich phase in tantalum alloy is caused, is also unfavorable for guaranteeing the mechanical property of material.It is right
In ratio 5, although few copper addition can guarantee intensity and plasticity index, the following table 4 is combined it is found that not ensuring that it has foot
Enough antibacterial functions.In comparative example 6 high copper content although can guarantee tantalum alloy have enough intensity, but high copper content into
One step aggravate tantalum alloy distortion of lattice, elongation percentage reduce, compactness is poor, and combine the following table 4 biological safety as a result, its
Biological relevance can not meet the requirement of implantation material relevant criterion yet.As it can be seen that only preparing work in hot isostatic pressing provided by the invention
In skill parameter area, it just can guarantee that material has high-compactness and excellent mechanical property.
Two, biology performance detects
1, anti-microbial property detects:
By the tantalum alloy of embodiment 1-9 and comparative example 1-7 according to " JIS Z 2801-2000 " antibacterial fabricated product-antibacterial
Property test method and antibacterial effect ", GB/T 2591-2003 " antibiotic plastic anti-microbial property experimental method and antibacterial effect " " etc. phases
Pass standard provides to carry out quantitative anti-microbial property detection.As a result the tantalum alloy of embodiment 1-9 and comparative example 1-7 are obtained to common sense
Sterilizing rate after microbiological contamination (Escherichia coli, staphylococcus aureus) effect.In-vitro antibacterial performance test results are shown in Table 4, wherein killing
The calculation formula of bacterium rate are as follows: sterilizing rate (%)=[(control viable count-experimental group alloy viable count)/control sample viable count] ×
100。
Specific experiment process are as follows:
Test is taken to be added drop-wise to control sample (Ta) with bacterium solution 0.3mL, on experimental group tantalum alloy sample respectively.With sterilizing tweezers
Cover film is overlayed on respectively on each sample, so that bacterium solution is uniformly contacted sample, is placed in sterilizing plates, be placed in constant incubator
37 DEG C, cultivate for 24 hours under 90% conditions above of relative humidity.The sample cultivated for 24 hours is taken out, is separately added into 15mL eluent, instead
Multiple cleaning sample and cover film, after sufficiently shaking up, take 0.1mL to be added drop-wise to plate nutrient agar, each sample does three respectively
A Duplicate Samples, and with sterilizing triangle rake smoothen, be placed in 37 DEG C of insulating boxs cultivate 48h after according to GB/T 4789.2 method into
Row count plate.
From table 4, it can be seen that the Medical tantalum copper alloy of the present invention with antibacterial functions compared with pure tantalum, has sterilization
Function, especially its sterilizing rate are reinforced with the increase of copper content.It can be seen that the present invention adds Cu member in medical pure tantalum metal
Element can assign tantalum copper alloy excellent anti-microbial property.
2, area and the thickness quantitative determination of bacterial biof iotalm:
The area of the tantalum alloy surface bacteria biomembrane of embodiment 1-9 and comparative example 1-7 is quantitative determined with thickness,
Further evaluation experimental material inhibits bacterial biof iotalm adhesive capacity.Specific steps are as follows:
Using the production of Invitrogen company of the U.S.BacLightTM Bacterial
It dyes on experimental material surface after Viability Kits L7012 fluorescent dye pair co-cultures for 24 hours with bacterial solution.BacLightTM Bacterial Viability Kits L7012 kit includes two kinds of fluorescence dyes
Toner is SYTO-9 and PI respectively.SYTO-9 coloring agent can be by living cells and dead cell stain, and is in green；PI coloring agent energy
Dead cell is dyed into red, and selectively only penetrates the cell membrane of dead cell, eucaryotic cell structure is destroyed, reduces itself and SYTO-9's
Colour developing, to make dead cell that red only be presented.Before dyeing, experimental material surface is molten with the 0.2mmol/mlPBS buffering of pH7.2
Liquid rinses 3 times gently to wash out culture medium solution.Staining procedure is carried out in strict accordance with kit specification, i.e., by 1.5 μ L
SYTO9 coloring agent is uniformly mixed with 1.5 μ L PI coloring agents, is diluted to 1ml using sterilized distilled water.After 200 μ L dilution
Coloring agent be added dropwise on experimental material surface, room temperature be protected from light dyeing 15min.After dyeing, is cleaned 3 times with PBS, swashed immediately
It is observed under light Laser Scanning Confocal Microscope.Each sample randomly selects five visual fields, analyzes experimental material using NIS Viewer software
The thickness and area of surface biological film.Specific experiment the results are shown in Table 4.
From table 4, it can be seen that the Medical tantalum copper alloy of the present invention with antibacterial functions is compared with pure tantalum, surface it is thin
The thickness of bacterium biomembrane and area are smaller.It can be seen that the present invention adds Cu element in medical pure tantalum metal effectively to inhibit thin
The generation and adherency of bacterium biomembrane, and then reduce the incidence of bacterium infection.
3, cytotoxicity detects:
The tantalum alloy of embodiment 1-9 and comparative example 1-7 are subjected to MTT (3- (4,5)-dimethylthiahiazo (- z-
Y1) -3,5-di-phenytetrazoliumromide, 3- (4,5- dimethylthiazole -2) -2,5- diphenyltetrazolium bromide bromide)
Bio-safety performance detection, i.e., according to national standard GBT16886.5-2003 BiologicalEvaluationofMedicalDevice, including the opposite proliferation of cell
Rate (RGR).
Using thiazolyl blue MTT colorimetric method for determining cells survival rate, and then evaluate the biological safety of sample.Mtt assay is one
The method of kind detection cell survival and growth, testing principle can make exogenous for the succinate dehydrogenase in living cells mitochondria
MTT is reduced to bluish violet crystallization first a ceremonial jade-ladle, used in libation (Formazan) of water-insoluble and is deposited in cell, and dead cell is without this function.
Concrete operation step are as follows: the cryopreservation tube of OS-732 cells MG63 is removed from liquid nitrogen, it is fast in 37 DEG C of water-baths
Speed is melted, and supernatant is abandoned in centrifugation, and DMEM (the dulbecco's modified containing 10% fetal calf serum of Fresh is added
Eagle medium, high glucose medium) in high glucose medium, is moved into culture bottle after blowing and beating into cell suspension repeatedly, be placed in 37
DEG C, relative saturation humidity (95%), volume fraction be 5% CO2Stationary culture in constant incubator, the next day change liquid.It passes within 3-4 days
It is commissioned to train feeding, observes cellular morphology under inverted phase contrast microscope.Take eugonic MG63 cell, 2.5g/L trypsin digestion
Afterwards, being prepared into cell density with the DMEM culture solution containing 10% fetal calf serum is about 6 × 104The single cell suspension of/mL, inoculation
In 9 piece of 96 well culture plate, every plate sets A, B, C, D, E, F, G, H, I experimental group and zeroing group, every group of 10 holes, the every Kong Zhongjun of experimental group
100 μ L of cell suspension, 37 DEG C, 5%CO are added2Under the conditions of stationary culture.Original fluid, PBS are discarded after cell adherent growth
Repeated flushing is loaded by experimental group.After 24 hours, 48 hours, 72 hours, 96 hours, 120 hours, every hole is added new sample-adding
The sterile MTT solution of the 5mg/mL of fresh preparation continues to cultivate the culture of termination in 4 hours.Original fluid is carefully discarded, every hole is added
150 μ L DMSO (Dimethyl sulfoxide, dimethyl sulfoxide), make for micro oscillator shaken cultivation plate 10 minutes at room temperature
Crystal sufficiently dissolves.Each hole O.D. (optical density, light are measured at 490nm wavelength with enzyme-linked immunosorbent assay instrument
Learn density) value.Experiment takes each cell mean in triplicate.Calculating RGR, (relative growth rate, cell is opposite to be proliferated
Rate), calculation formula: RGR=(experimental group O.D. value/culture medium O.D. value) × 100% evaluates each group result, as a result
It is shown in Table 4.
From table 4, it can be seen that Medical tantalum copper alloy and comparative example described in the embodiment of the present invention with antibacterial functions
Tantalum copper alloy is compared with more preferably cell with respect to appreciation rate, and the tantalum copper alloy in copper preferred scope has highest cell phase
To appreciation rate, illustrate that the addition of copper not only assigns tantalum metal excellent anti-microbial property, while improving its bio-compatible performance.And
The tantalum copper alloy provided in comparative example, except comparative example 5 (low copper levels, however anti-microbial property is poor), comparative example 7 (pure tantalum) it is thin
Cell phase is more excellent to appreciation rate outer, remaining comparative example, though the copper range of some comparative examples in range provided by the invention, but by
Technological parameter is prepared not in scope of the claims provided by the invention in its hot isostatic pressing, leads to its mechanical property, densification
Property and corrosion resisting property are poor, thus it is too low with respect to appreciation rate to eventually lead to cell, is unsatisfactory for bio-medical material to implantation
The relevant criterion of object biocompatibility.
4, apoptosis rate detects:
The tantalum alloy of embodiment 1-9 and comparative example 1-7 are subjected to FCM analysis, and then further quantitative detection experiment
The cell compatibility of material.It is 2 × 10 by concentration5The MG63 cell inoculation cultivated in the cytotoxicity detection of/ml is in experiment material
Expect surface.Pancreatin digests after 48h, and cell is resuspended in cold PBS piping and druming, and the cell suspension of resuspension is centrifuged in 4 DEG C, 1000r/min
10min.The cell being collected into is moved into streaming pipe, is washed 2 times with PBS, cell is resuspended with the Buffer buffer of 200 μ L.Add
Enter 10 μ LAnnexinV-FITC and 5 μ L PI, mix gently, is protected from light is incubated for 10-15min at room temperature.In 500-1000r/
It is centrifuged 5min under min, 300 μ L Buffer buffers are added, the cell of flow cytomery different materials culture is used in 1h
Apoptosis situation calculates apoptosis rate, the results are shown in Table 4.
From table 4, it can be seen that Medical tantalum copper alloy and comparative example described in the embodiment of the present invention with antibacterial functions
Tantalum alloy illustrates copper compared to the tantalum copper alloy Apoptosis minimum number in Apoptosis negligible amounts or even copper preferred scope
Be added and not only assign tantalum metal excellent anti-microbial property, while improving its bio-compatible performance.And provided in comparative example
The apoptosis rate of tantalum copper alloy, comparative example 7 (pure tantalum) is lower, remaining comparative example, even if the copper range of some comparative examples is at this
It invents in the scope of the claims provided, since its hot isostatic pressing prepares technological parameter not in claim provided by the invention
In range, cause its mechanical property, compactness and corrosion resisting property poor, thus eventually leads to apoptosis rate and significantly increase
Height has poor biocompatibility.
5, pitting potential performance test:
The tantalum alloy of embodiment 1-9 and comparative example 1-7 are subjected to corrosion resisting property detection, i.e., according to pitting potential measurement method
It is bent that (national standard: GB/T 17899-1999) carries out anode polarization to the tantalum alloy of 1-9 of the embodiment of the present invention and comparative example 1-7
Line test, test result are shown in Table 4.
From table 4, it can be seen that the tantalum copper of medical tantalum alloy and comparative example described in the embodiment of the present invention with antibacterial functions
Alloy is compared, pitting potential with higher, and especially the tantalum copper alloy in copper preferred scope has highest spot corrosion electricity
Position, illustrates it with stronger corrosion-resistant ability.The pitting potential of alloy of the present invention meets national respective standard requirement, i.e.,
Pitting potential is more than 800mV, can significantly increase the microbial corrosion resistance ability of material, improves the anticorrosive risk of material.And
Comparative example provide tantalum copper alloy, even if the copper range of some comparative examples in range provided by the invention, since its heat etc. is quiet
Press preparation technology parameter in scope of the claims provided by the invention, therefore corrosion-resistant ability is declined, with compared with
The corrosion-resistant ability of difference.
The performance test results of 4 embodiment and comparative example tantalum copper alloy of table
To sum up, by above embodiments it is found that only when Cu content, hot isostatic pressing preparation technique ginseng are mentioned in the present invention simultaneously
In the scope of the claims of confession, it can just prepare while have both excellent mechanical property, compactness, corrosion resisting property, antibacterial functions
And the novel antibacterial Medical tantalum copper alloy of biocompatibility.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar cans understand the content of the present invention and implement it accordingly, and it is not intended to limit the scope of the present invention.It is all according to the present invention
Equivalent change or modification made by Spirit Essence should all cover in protection scope of the present invention.
Claims (3)
1. a kind of Medical tantalum copper alloy with antibacterial functions, which is characterized in that its chemical component is weight percentage: copper: 10-
15%, surplus is tantalum；
Preparation process includes mixed two steps of powder and hip moulding；The detailed process of hip moulding are as follows: by vacuum seal
Dress is formed equipped with being wrapped in hot isostatic press for alloy powder, and heat and other static pressuring processes parameter area is 1200 DEG C -1400 DEG C/
200MPa-300MPa/4h-10h is closed using each tantalum copper densified of being suppressed to impartial static pressure at high temperature
Gold.
2. according to Medical tantalum copper alloy described in claim 1, it is characterised in that: be respectively less than 200 μm of pure tantalum powder with average particle size
End and fine copper powder are raw material, and raw material powder is put into batch mixer and is carried out dry-type mechanical mixing 20-30 hours.
3. a kind of application of the Medical tantalum copper alloy described in claim 1 with antibacterial functions, it is characterised in that: the alloy is used
It is fixed in suture bone, tendon, fascia and tooth, or for the suture of internal organ operation, or is applied to orthopaedics, the department of stomatology, angiocarpy
Each eka-tantalum copper alloy implanted medical device used in bracket intervention field.
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| CN109536804B (en) * | 2018-12-05 | 2020-07-03 | 湖北第二师范学院 | Tantalum alloy, diamond-like carbon coating tantalum alloy bone claw for biomedical implantation and preparation method thereof |
| CN109652692B (en) * | 2018-12-05 | 2020-05-26 | 湖北第二师范学院 | Hydrogen-embrittlement-resistant tantalum alloy for biomedical implantation, and production method, application and material thereof |
| CN115747596A (en) * | 2022-11-18 | 2023-03-07 | 东莞宜安科技股份有限公司 | Antibacterial osteogenesis-promoting medical nano porous tantalum-copper alloy and preparation method thereof |
| CN116808301A (en) * | 2023-08-29 | 2023-09-29 | 北京市春立正达医疗器械股份有限公司 | Bone implant material with tantalum-copper coating deposited on surface and preparation method thereof |
| CN116837343A (en) * | 2023-08-29 | 2023-10-03 | 北京市春立正达医疗器械股份有限公司 | Method for preparing copper-plated medical tantalum metal material by chemical vapor deposition |
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