CN106702240A - Medical tantalum-cuprum alloy having anti-bacterial function and preparation method thereof - Google Patents
Medical tantalum-cuprum alloy having anti-bacterial function and preparation method thereof Download PDFInfo
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Abstract
The invention provides a novel medical anti-bacterial tantalum-cuprum (Ta-Cu) alloy and a preparation method thereof. The novel medical anti-bacterial tantalum-cuprum (Ta-Cu) alloy comprises, by weight percentage, 5-20% of cuprum (Cu) and the balance tantalum (Ta). The medical tantalum-cuprum alloy is prepared through a hot isostatic pressure method; and by means of optimized preparation process parameters, the tantalum-cuprum alloy which is excellent in mechanical performance and has the anti-bacterial function can be obtained. The obtained medical tantalum-cuprum alloy has the unique anti-bacterial function, can remarkably lower bacterial infection risks caused in the using process of tantalum-based alloy implanted medical apparatus and instruments in existing medical technologies, is mainly used for suturing bones, tendons and fascia and fixing teeth or used for conducting suturing in viscera operations and can also be widely applied to various tantalum-cuprum alloy implanted medical apparatus and instruments used in the clinical field of medical science such as orthopedics, stomatology and cardiovascular stent intervention.
Description
Technical field
The invention belongs to technical field of biological materials, medical metal material field is particularly well-suited to, specifically
It is a kind of Medical tantalum copper alloy with antibacterial functions and its preparation.
Background technology
Metal tantalum is with the structural property of its excellent chemical stability, excellent biological characteristics and uniqueness
The extensive concern on biomedical boundary is caused.Compared with existing medical metal material, tantalum mainly has
Both sides clear superiority：(1) tantalum has more excellent chemical stability and corrosion resisting property, often
Under temperature, tantalum does not chemically react with hydrochloric acid, concentrated nitric acid even " chloroazotic acid ", and general inorganic salts are to tantalum
Without corrosiveness；(2) biocompatibility of tantalum is splendid, after implantation a period of time, biological group
Knit and easily grown on tantalum surface, so tantalum has the title of " close biological metal " again.The many advantages of metal tantalum are
It provides wide development space in the application of medical field.Current metal tantalum has in the medical field
Following application：Because the ductility of tantalum is good, even more thin filament suitable with hairline is can be made into.Tantalum
Silk possesses the advantages of sterilizing is simple, stimulation is smaller, tension stress is big as operation suture thread, is mainly used in
Suture bone, tendon, manadesma and tooth are fixed, or for the suture of internal organ operation.
However, as medical metal material is increasingly widely applied, a series of problems for bringing therewith,
The POI (BCI) triggered centered on including being implanted into by medical metal material is more and more frequent,
An important problem demanding prompt solution as clinical treatment.The tables of data of World Health Organization's issue
It is bright, 14,000,000 people are had more than in annual hospital and is enduring the pain that inflammation of bacterium infection induction etc. is brought to the fullest extent
Hardship, wherein 60% bacterium infection is relevant with the use of implant.In field of orthopaedics, in sterile working
And under the premise of systemic prophylaxis anti-inflammatory treatment, the bacterium infection hair after first time replacement of total hip
Raw rate infection rate of the internal prosthesis replacement of a large amount of Cranial defects after 0.5-3.0%, tumor resection exists
There is POI in the case of the row exterior fixing rack operation of 5-35%, 2-30%.There is statistics to show：
MRSE and staphylococcus aureus are the main bacterias for triggering the infection of orthopaedics implantation instrument, than
Example is respectively 34% and 32%, other coccus ratios 13%.Therefore, what medical metal material triggered is thin
Bacterium infection has become and restricts one of its key factor for developing.Additionally, good biocompatibility
It is one of prerequisite performance of medical metal material.Biocompatibility refers to life entity tissue to material
A kind of aitiogenic performance, including histocompatbility and blood compatibility.Good biocompatibility
It is the primary requirement to implant material.The biocompatibility of material includes histocompatbility and blood phase
Capacitive, is to evaluate the problem that novel biomaterial must take into consideration.
Therefore, the deficiencies in the prior art are：There is presently no itself having a bacterial-infection resisting, and and
Has the medical metal implanted material of superior bio compatibility.
The content of the invention
The present invention is regarding to the issue above, it is proposed that a kind of antibacterial work(with excellent bio-compatible performance
The new medical tantalum copper alloy of energy, to solve existing metal implant material itself without bacterial-infection resisting
The problem of function.
To achieve the above object, the technical solution adopted by the present invention is：Added in Medical tantalum metal suitable
The copper (Cu) of amount, its chemical composition is weight percentage：Copper (Cu)：5-20%, surplus
It is tantalum (Ta).During other impurity contents should meet medical tantalum-base alloy national standard in the alloy
Corresponding requirements.The percentage by weight of wherein Cu elements is preferably：Cu：10-15%.The alloy has
There is significant anti-microbial property, and have excellent biocompatibility concurrently, be not only expected to reduce the implantation of tantalum metal
The infection rate of device surrounding tissue in Clinical practice, moreover it is possible to significantly improve tissue and tantalum metal device
The biocompatibility of part, and then improve the medical functions and success rate of tantalum metal implant devices.
In the composition design of the Medical tantalum copper alloy with antibacterial functions of the invention, Cu is the present invention
Most important alloying element in the Medical tantalum copper alloy, this is to ensure that tantalum copper alloy has antibacterial functions
And have the necessary condition of superior bio compatibility concurrently, it is also one of main innovation point of the invention.This hair
Bright is that appropriate copper is added in Medical tantalum metal, to ensure that micro copper ion can be from tantalum alloy
Surface endurance discharges, so as to assign tantalum metal antibacterial function.If copper content is relatively low, tantalum alloy
Enough copper ions can not be discharged, the antibacterial functions of tantalum alloy can be reduced.If copper content is relatively too high,
Can then cause tantalum alloy to discharge excessive copper ion, and then influence the corrosion resisting property and biological peace of tantalum alloy
Quan Xing, too high copper content can also have a negative impact to the mechanical property and processing characteristics of tantalum alloy.
Only in the range of the Cu contents that the present invention is provided, tantalum copper alloy could simultaneously ensure excellent antibacterial
Performance and bio-compatible performance.
In the preparation method present invention also offers the Medical tantalum copper alloy, it is characterised in that：Prepare
Process includes two steps of mixed powder and hip moulding.
Mixed powder：The pure tantalum powder and fine copper powder of 200um are respectively less than as raw material with particle mean size, by original
Feed powder end is put into batch mixer and carries out dry-type mechanical mixing 20-30 hours.
Hip moulding：By Vacuum Package equipped with alloy powder be wrapped in hot isostatic press into
Type, heat and other static pressuring processes parameter preferred scope is 1200 DEG C -1400 DEG C/200MPa-300MPa/4h-10h,
At high temperature using each tantalum copper alloy for impartial static pressure suppress and being densified.
Tantalum copper alloy cannot be prepared using traditional fire metallurgy process, process has larger difficulty.Reason
The fusing point for being metal tantalum is 3020 DEG C, and the boiling point of copper is 2563 DEG C, is smelted with pyrometallurgic methods
The gasification volatilization of metallic copper is easily caused during tantalum copper alloy, it is difficult to control copper in tantalum alloy receives rate
And composition, method Medical tantalum copper alloy of the preparation with antibacterial functions using powder metallurgy of the invention.
High temperature insostatic pressing (HIP) method is the preparation method that a kind of preferred powder metallurgy prepares tantalum copper alloy, and the method
Relate to the optimization process of preparation parameter such as sintering temperature, soaking time, sintering pressure etc..Such as,
Sintering temperature is too low, then be possible to cause material density to reduce, and in turn results in material mechanical performance
The not enough problem with corrosion resisting property, sintering temperature is too high, can also cause low melting point copper-rich phase in tantalum alloy
Liquefaction, the mechanical property and corrosion resisting property of heavy damage material.Meanwhile, soaking time is less and sinters
Pressure is too low, can cause the porosity of tantalum copper alloy and increase, density reduction, so as to influence material
Performance, soaking time is long and sintering pressure is larger, can't greatly improve the correlation of material
Can, while can also increase the technical requirements and preparation cost of equipment.Therefore, only provided in the present invention
Suitable high temperature insostatic pressing (HIP) prepare in the range of technological parameter, Medical tantalum copper alloy can just ensure enough
Mechanical property and corrosion resisting property, and then can just give full play to its antibacterial functions.
Medical tantalum copper alloy with antibacterial functions of the present invention is mainly used in suture bone, tendon, muscle
Film and tooth are fixed, or for internal organ operation suture, be also widely applied to orthopaedics, the department of stomatology,
Each eka-tantalum copper alloy implanted medical device used in the clinical medicine fields such as angiocarpy bracket intervention.
The beneficial effects of the invention are as follows：
1st, the optimization that the present invention passes through heat and other static pressuring processes parameter in powder metallurgy, prepare mechanical property,
The new medical tantalum copper alloy of corrosion resisting property, excellent antibacterial performance.
2nd, when Medical tantalum copper alloy of the present invention is as implant, can be to persistently being released in its tissue around
Micro Cu element is put, can not only be anti-infective, moreover it is possible to effectively improve bio-compatible performance, can be extensive
Each eka-tantalum metal for being applied to be used in the clinical medicine such as orthopaedics, the department of stomatology, angiocarpy bracket field is planted
Enter medicine equipment.
Specific embodiment
Chemical composition ranges according to set by tantalum copper alloy of the present invention, using the preparation work of powder metallurgy
Process, prepares embodiment 1-9 and each 1 kilogram of comparative example 1-7 tantalum copper alloys, embodiment 1-9 and
The chemical composition data of the tantalum copper alloy of comparative example 1-7 is shown in Table 1.
The chemical composition (weight %) of the embodiment of table 1 and comparative example tantalum copper alloy
Process of preparing comprises the following steps：
(1) mixed material：The pure tantalum powder and fine copper powder of 45um are as raw material with particle mean size,
Every group of alloy composition according to table 1 matches into the material powder that gross mass is 1kg, by raw material powder
End is put into batch mixer and carries out dry-type mechanical mixing 25 hours.
(2) hip moulding：The pure Ta jackets equipped with alloy powder of Vacuum Package are put into heat
In isostatic pressing machine, heat and other static pressuring processes parameter is as shown in table 2.
The heat and other static pressuring processes parameter designing of table 2
At high temperature using each tantalum copper alloy for impartial static pressure suppress and being densified.Through
Sample after HIP sintering is processed into Mechanics Performance Testing and biology performance test sample, related
Method of testing and result are as follows：
First, tantalum copper alloy Mechanics Performance Testing
Tantalum copper alloy idiosome after high temperature insostatic pressing (HIP) is taken out, the tantalum copper alloy idiosome obtained by each example is used
Archimedes's drainage measures the bulk density of idiosome, as a result as shown in table 3.Take part tantalum copper alloy
Processed with the method for wire cutting and sample and mark, cut the sample of 10mm × 10mm × 2mm specifications, warp
Hardness test and antibacterial experiment are carried out after crossing sanding and polishing, is determined with HVS-1000 micro Vickerses
Sample hardness, load 1.96N protects lotus time 20S, and Determination of Hardness result is as shown in table 3.By GB
Pole shape tensile sample is processed into, tension test is carried out in MTS810 Material Testing Machine, as a result such as
Shown in table 3.
The mechanical property of the embodiment of table 3 and comparative example tantalum copper alloy
As known from Table 3, when high temperature insostatic pressing (HIP) prepares technological parameter all in setting range of the invention,
Embodiment 1-9 tantalum copper alloys are respectively provided with high-compactness and excellent mechanical property.When high temperature insostatic pressing (HIP) prepares work
Skill parameter at least one when being unsatisfactory for setting range of the invention, tantalum copper alloy consistency is low, mechanics
Poor performance, is unsatisfactory for the performance of material.As the sintering temperature of comparative example 1 is too low, tantalum copper is caused to close
The consistency reduction of gold, causes intensity and elongation percentage index to be below embodiment tantalum copper alloy.Comparative example 2
With 4 because soaking time is less and sintering pressure is too low in preparation technology parameter, can cause that tantalum copper is closed
The porosity of gold increases, density reduction, ultimately results in the not enough influence material of mechanical property of tantalum copper alloy
Applicable performance.Comparative example 3 causes low melting point copper-rich phase in tantalum alloy then because sintering temperature is too high
Liquefaction, be also unfavorable for ensure material mechanical property.In comparative example 5, although few copper addition energy
Proof strength and plasticity index, but combine knowable to table 4 below, do not ensure that it has enough antibacterials
Function.Although copper content high can guarantee that tantalum alloy has enough intensity in comparative example 6, but high
Copper content is further exacerbated by the distortion of lattice of tantalum alloy, and elongation percentage is reduced, and compactness is poor, and combines
The biological safety result of table 4 below, its biological relevance can not meet the requirement of implant relevant criterion yet.
It can be seen that, the high temperature insostatic pressing (HIP) for only being provided in the present invention is prepared in process parameters range, just can guarantee that material
With high-compactness and excellent mechanical property.
2nd, biology performance detection
1st, anti-microbial property detection：
By the tantalum alloy of embodiment 1-9 and comparative example 1-7 according to " JIS Z 2801-2000《Antibacterial processing system
Product-antibiotic property test method and antibacterial effect》、GB/T 2591-2003《Antibiotic plastic anti-microbial property reality
Proved recipe method and antibacterial effect》" etc. correlation standard carry out quantitative anti-microbial property detection.Result is obtained
The tantalum alloy of embodiment 1-9 and comparative example 1-7 is to frequent infectious bacteria (Escherichia coli, Staphylococcus aureus
Bacterium) effect after sterilizing rate.In-vitro antibacterial performance test results are shown in Table 4, and the wherein calculating of sterilizing rate is public
Formula is：Sterilizing rate (%)=[(control viable count-experimental group alloy viable count)/control sample viable bacteria
Number] × 100.
Specific experiment process is：
Experiment bacterium solution 0.3mL is taken respectively is added drop-wise to control sample (Ta), experimental group tantalum alloy sample
On.Cover layer is overlayed on each sample respectively with sterilizing tweezers, makes bacterium solution uniform contact sample, put
In sterilizing plates, it is placed on 37 DEG C in constant incubator, cultivates 24h under the conditions above of relative humidity 90%.
The sample of 24h has been cultivated in taking-up, is separately added into 15mL eluents, repeatedly cleaning sample and cover layer,
After fully shaking up, 0.1mL being taken respectively and being added drop-wise to plate nutrient agar, each sample does three and puts down
Row sample, and smoothened with sterilizing triangle rake, it is placed in 37 DEG C of insulating boxs after culture 48h according to GB/T 4789.2
Method carry out count plate.
From table 4, it can be seen that the Medical tantalum copper alloy with antibacterial functions of the present invention and pure tantalum phase
Than strengthening with the increase of copper content with sterilizing function, particularly its sterilizing rate.It can be seen that this hair
The bright Cu elements that added in medical pure tantalum metal can assign tantalum copper alloy excellent anti-microbial property.
2nd, the area of bacterial biof iotalm and thickness are quantitative determined：
Area to the tantalum alloy surface bacteria biomembrane of embodiment 1-9 and comparative example 1-7 is carried out with thickness
Quantitative determination, further evaluation experimental material suppresses bacterial biof iotalm adhesive capacity.Concretely comprise the following steps：
Produced using Invitrogen companies of the U.S.BacLightTM Bacterial
Viability Kits L7012 fluorescent dyes pair co-culture the experiment material surface after 24h with bacterial solution
Dyeed.BacLightTM Bacterial Viability Kits L7012 kits
It is respectively SYTO-9 and PI comprising two kinds of fluorescent dyes.SYTO-9 coloring agents can by living cells with
Dead cell stain, and in green；Dead cell can be dyed red by PI coloring agents, and optionally only be worn
The cell membrane of saturating dead cell, destroys eucaryotic cell structure, its colour developing with SYTO-9 is reduced, so that extremely
Cell is only presented red.Before dyeing, experiment material surface is delayed with the 0.2mmol/mlPBS of pH7.2
Rush solution and gently rinse 3 times so that culture medium solution is washed out.Staining procedure is said in strict accordance with kit
Bright book is carried out, will 1.5 μ L SYTO9 coloring agents be well mixed with 1.5 μ L PI coloring agents, using
The distilled water diluting of sterilizing is to 1ml.Coloring agent after 200 μ L are diluted is added dropwise on experiment material surface,
Room temperature lucifuge dyes 15min.After dyeing terminates, with PBS 3 times, immediately in laser co-focusing
Basis of microscopic observation.Each sample randomly selects five visual fields, using NIS Viewer software analysis realities
Test the thickness and area of material surface biomembrane.Specific experiment the results are shown in Table 4.
From table 4, it can be seen that the Medical tantalum copper alloy with antibacterial functions of the present invention and pure tantalum phase
Than the thickness of the bacterial biof iotalm on surface is smaller with area.It can be seen that the present invention is in medical pure tantalum metal
Middle addition Cu elements can effectively suppress the generation and adhesion of bacterial biof iotalm, and then reduce bacterium infection
Incidence.
3rd, cytotoxicity detection：
The tantalum alloy of embodiment 1-9 and comparative example 1-7 is carried out into MTT (3- (4,5)-dimethylthiahiazo
(- z-y1) -3,5-di-phenytetrazoliumromide, 3- (4,5- dimethylthiazole -2) -2,5- hexichol
Base tetrazole bromide) detection of bio-safety performance, i.e., according to GB GBT16886.5-2003 Medical treatment devices
Tool biological assessment, including cell is with respect to proliferation rate (RGR).
Using tetrazolium bromide MTT colorimetric method for determining cells survival rates, and then evaluate the biological safety of sample.
Mtt assay is a kind of method for detecting cell survival and growth, and its Cleaning Principle is in living cells mitochondria
Succinate dehydrogenase can make exogenous MTT be reduced to water-insoluble bluish violet crystallization first a ceremonial jade-ladle, used in libation
(Formazan) and it is deposited in cell, and dead cell is without this function.
Concrete operation step is：The cryopreservation tube of OS-732 cells MG63 is taken out from liquid nitrogen,
Supernatant is abandoned in fast melt in 37 DEG C of water-baths, centrifugation, add Fresh containing 10% hyclone
In DMEM (dulbecco's modified eagle medium, high glucose medium) high glucose medium,
Blowing and beating into repeatedly in move into after cell suspension blake bottle, be placed in 37 DEG C, relative saturation humidity (95%),
Volume fraction is 5% CO2Quiescent culture in constant incubator, the next day change liquid.3-4 days Secondary Cultures,
The observation of cell form under inverted phase contrast microscope.Take eugonic MG63 cells, 2.5g/L pancreases
After protease digestion, it is prepared into cell density with the DMEM nutrient solutions containing 10% hyclone and is about
6×104The single cell suspension of/mL, is inoculated in 9 piece of 96 well culture plate, per plate set A, B, C, D,
E, F, G, H, I experimental group and zeroing group, every group of 10 holes, experimental group add cell to hang per Kong Zhongjun
Liquid 100 μ L, 37 DEG C, 5%CO2Under the conditions of quiescent culture.Former culture is discarded after cell attachment grows
Liquid, PBS is rinsed repeatedly, empirically packet sample-adding.Sample-adding 24 hours, 48 hours, 72 hours,
96 hours, after 120 hours, per hole add Fresh 5mg/mL aseptic MTT solution, after
Continuous culture terminates culture in 4 hours.Original fluid carefully is discarded, 150 μ L DMSO are added per hole
(Dimethyl sulfoxide, dimethyl sulfoxide (DMSO)), at room temperature 10 points of micro oscillator shaken cultivation plate
Clock makes crystal fully dissolve.Each hole O.D. is determined at 490nm wavelength with enzyme-linked immunosorbent assay instrument
(optical density, optical density (OD)) value.Experiment takes each cell mean in triplicate.Calculate RGR
(relative growth rate, cell is with respect to proliferation rate), computing formula：RGR=(experimental group O.D.
Value/culture medium O.D. values) × 100%, each group result is evaluated, the results are shown in Table 4.
From table 4, it can be seen that the Medical tantalum copper alloy with antibacterial functions described in the embodiment of the present invention
There is more excellent cell compared with the tantalum copper alloy of comparative example with respect to appreciation rate, and in copper preferred scope
Tantalum copper alloy has highest cell with respect to appreciation rate, and illustrating the addition of copper, not only to assign tantalum metal excellent
Anti-microbial property, while improve its bio-compatible performance.And the tantalum copper alloy provided in comparative example,
Except comparative example 5 (low copper levels, but anti-microbial property is poor), the cell phase of comparative example 7 (pure tantalum)
It is more excellent to appreciation rate outer, remaining comparative example, even if what the copper scope of some comparative examples was provided in the present invention
In the range of, but because its high temperature insostatic pressing (HIP) prepares the claim model that technological parameter is not provided in the present invention
In enclosing, cause its mechanical property, compactness and corrosion resisting property poor, thus ultimately result in cell
It is too low with respect to appreciation rate, it is unsatisfactory for relevant criterion of the bio-medical material to implant biocompatibility.
4th, apoptosis rate detection：
The tantalum alloy of embodiment 1-9 and comparative example 1-7 is carried out into FCM analysis, so it is further fixed
Measure the cell compatibility of test experience material.It is 2 × 10 by concentration5Cultivated in the cytotoxicity detection of/ml
MG63 cells be inoculated in experiment material surface.Pancreatin digestion after 48h, cold PBS piping and druming is resuspended thin
Born of the same parents, by resuspended cell suspension in 4 DEG C, 1000r/min centrifugations 10min.The cell that will be collected into is moved
Enter in streaming pipe, washed 2 times with PBS, with the Buffer buffer solution re-suspended cells of 200 μ L.Add
10 μ LAnnexinV-FITC and 5 μ L PI, gently mix, and lucifuge is incubated 10-15min at room temperature.
5min is centrifuged under 500-1000r/min, 300 μ L Buffer buffer solutions are added, streaming is used in 1h
Cell instrument detects the Apoptosis situation of different materials culture, calculates apoptosis rate, the results are shown in Table 4.
From table 4, it can be seen that the Medical tantalum copper alloy with antibacterial functions described in the embodiment of the present invention
Tantalum copper alloy in the Apoptosis negligible amounts compared with the tantalum alloy of comparative example, or even copper preferred scope
Apoptosis minimum number, illustrates that the addition of copper not only assigns tantalum metal excellent anti-microbial property, while
Improve its bio-compatible performance.And the tantalum copper alloy provided in comparative example, comparative example 7 (pure tantalum)
Apoptosis rate is relatively low, remaining comparative example, though what the copper scope of some comparative examples was provided in the present invention
In right, because its high temperature insostatic pressing (HIP) prepares the right that technological parameter is not provided in the present invention
In claimed range, cause its mechanical property, compactness and corrosion resisting property poor, thus finally lead
Apoptosis rate is caused significantly to increase, with poor biocompatibility.
5th, pitting potential performance test：
The tantalum alloy of embodiment 1-9 and comparative example 1-7 is carried out into corrosion resisting property detection, i.e., according to spot corrosion electricity
Position measuring method (national standard：GB/T 17899-1999) to embodiment of the present invention 1-9 and comparative example
The tantalum alloy of 1-7 carries out anodic polarization curves test, and test result is shown in Table 4.
From table 4, it can be seen that described in the embodiment of the present invention with antibacterial functions medical tantalum alloy with it is right
The tantalum copper alloy of ratio is compared, with pitting potential higher, particularly copper preferred scope
Tantalum copper alloy has highest pitting potential, illustrates that it has stronger corrosion-resistant ability.Institute of the present invention
The pitting potential for stating alloy meets national respective standard requirement, i.e. pitting potential, can more than 800mV
The microbial corrosion resistance ability of material is significantly increased, the anticorrosive risk of material is improved.And comparative example is carried
The tantalum copper alloy of confession, even if the copper scope of some comparative examples is in the range of the present invention is provided, due to it
High temperature insostatic pressing (HIP) prepares technological parameter not in the right that the present invention is provided, therefore resistance to spot corrosion
Ability has declined, with poor corrosion-resistant ability.
The performance test results of the embodiment of table 4 and comparative example tantalum copper alloy
To sum up, by above example, only when Cu contents, high temperature insostatic pressing (HIP) prepare technique ginseng together
When the present invention provide right in, can just prepare at the same have concurrently excellent mechanical property,
The novel antibacterial Medical tantalum copper alloy of compactness, corrosion resisting property, antibacterial functions and biocompatibility.
The above embodiments merely illustrate the technical concept and features of the present invention, and this is familiar with its object is to allow
The personage of technology will appreciate that present disclosure and implements according to this, can not limit the present invention with this
Protection domain.Any equivalent change or modification in accordance with the spirit of the invention, should all cover
Protection scope of the present invention.
Claims (6)
1. a kind of Medical tantalum copper alloy with antibacterial functions, it is characterised in that its chemical composition is attached most importance to
Amount percentage：Copper：5-20%, balance of tantalum.
2. according to the Medical tantalum copper alloy with antibacterial functions described in claim 1, it is characterised in that：
Copper content is weight percentage Cu in the alloy：10-15%.
3. the preparation method of Medical tantalum copper alloy described in a kind of claim 1, it is characterised in that：Prepare
Process includes two steps of mixed powder and hip moulding.
4. according to the preparation method of Medical tantalum copper alloy described in claim 3, it is characterised in that：With flat
The pure tantalum powder and fine copper powder that equal granularity is respectively less than 200um are raw material, and material powder is put into batch mixing
Machine carries out dry-type mechanical mixing 20-30 hours.
5. according to the preparation method of Medical tantalum copper alloy described in claim 3, it is characterised in that：Will be true
What sky was encapsulated is wrapped in shaping, heat and other static pressuring processes parameter model in hot isostatic press equipped with alloy powder
It is 1200 DEG C -1400 DEG C/200MPa-300MPa/4h-10h to enclose, at high temperature using each to the quiet of equalization
Pressure suppress the tantalum copper alloy being densified.
6. a kind of application of the Medical tantalum copper alloy with antibacterial functions described in claim 1, its feature
It is：The alloy is fixed for suturing bone, tendon, manadesma and tooth, or for internal organ operation
Suture, or each eka-tantalum copper for being applied to be used in orthopaedics, the department of stomatology, angiocarpy bracket intervention field is closed
Golden implanted medical device.
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| CN109536804A (en) * | 2018-12-05 | 2019-03-29 | 湖北第二师范学院 | Tantalum alloy, diamond-like-carbon coating tantalum alloy and diamond-like-carbon coating biomedicine implantation tantalum alloy bone pawl and preparation method thereof |
| CN109652692A (en) * | 2018-12-05 | 2019-04-19 | 湖北第二师范学院 | Biomedicine implantation anti-hydrogen embrittlement tantalum alloy and its production method, application and material |
| CN115747596A (en) * | 2022-11-18 | 2023-03-07 | 东莞宜安科技股份有限公司 | Antibacterial osteogenesis-promoting medical nano porous tantalum-copper alloy and preparation method thereof |
| CN116808301A (en) * | 2023-08-29 | 2023-09-29 | 北京市春立正达医疗器械股份有限公司 | Bone implant material with tantalum-copper coating deposited on surface and preparation method thereof |
| CN116837343A (en) * | 2023-08-29 | 2023-10-03 | 北京市春立正达医疗器械股份有限公司 | Method for preparing copper-plated medical tantalum metal material by chemical vapor deposition |
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| CN107829123A (en) * | 2017-10-09 | 2018-03-23 | 深圳市中科摩方科技有限公司 | A kind of aluminium alloy of surface duplex coating and its preparation method and application |
| CN109536804A (en) * | 2018-12-05 | 2019-03-29 | 湖北第二师范学院 | Tantalum alloy, diamond-like-carbon coating tantalum alloy and diamond-like-carbon coating biomedicine implantation tantalum alloy bone pawl and preparation method thereof |
| CN109652692A (en) * | 2018-12-05 | 2019-04-19 | 湖北第二师范学院 | Biomedicine implantation anti-hydrogen embrittlement tantalum alloy and its production method, application and material |
| CN115747596A (en) * | 2022-11-18 | 2023-03-07 | 东莞宜安科技股份有限公司 | Antibacterial osteogenesis-promoting medical nano porous tantalum-copper alloy and preparation method thereof |
| CN116808301A (en) * | 2023-08-29 | 2023-09-29 | 北京市春立正达医疗器械股份有限公司 | Bone implant material with tantalum-copper coating deposited on surface and preparation method thereof |
| CN116837343A (en) * | 2023-08-29 | 2023-10-03 | 北京市春立正达医疗器械股份有限公司 | Method for preparing copper-plated medical tantalum metal material by chemical vapor deposition |
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