CN106699706A - Gluconic acid calcium ascorbate as well as preparation method and application thereof - Google Patents
Gluconic acid calcium ascorbate as well as preparation method and application thereof Download PDFInfo
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- CN106699706A CN106699706A CN201611240102.6A CN201611240102A CN106699706A CN 106699706 A CN106699706 A CN 106699706A CN 201611240102 A CN201611240102 A CN 201611240102A CN 106699706 A CN106699706 A CN 106699706A
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- gluconic acid
- calcium ascorbate
- acid calcium
- preparation
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 title claims abstract description 56
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 235000012208 gluconic acid Nutrition 0.000 title claims abstract description 50
- 239000000174 gluconic acid Substances 0.000 title claims abstract description 50
- 235000010376 calcium ascorbate Nutrition 0.000 title claims abstract description 42
- 229940047036 calcium ascorbate Drugs 0.000 title claims abstract description 42
- 239000011692 calcium ascorbate Substances 0.000 title claims abstract description 42
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 30
- 239000011575 calcium Substances 0.000 claims abstract description 23
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 12
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 12
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- 235000012255 calcium oxide Nutrition 0.000 claims abstract description 9
- 239000000292 calcium oxide Substances 0.000 claims abstract description 9
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 9
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000013305 food Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 230000035484 reaction time Effects 0.000 claims description 3
- 239000000047 product Substances 0.000 abstract description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 13
- 229910052791 calcium Inorganic materials 0.000 abstract description 13
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 206010006451 bronchitis Diseases 0.000 abstract description 3
- 238000001816 cooling Methods 0.000 abstract description 3
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 239000013589 supplement Substances 0.000 abstract description 3
- 208000001132 Osteoporosis Diseases 0.000 abstract description 2
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract 2
- 208000018944 leg cramp Diseases 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 7
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 235000007983 food acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 238000010671 solid-state reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3544—Organic compounds containing hetero rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a new substance, namely gluconic acid calcium ascorbate, having a chemical molecular formula of Ca(C6H7O6)(C6H11O7).H2O and a molecular weight of 428.39. A preparation method of the gluconic acid calcium ascorbate provided by the invention comprises the following steps: (1) adding calcium oxide, ascorbic acid and gluconic acid into a reaction vessel to perform a chemical reaction; (2) drying a product after full reaction; and (3) cooling the dried product to a room temperature to obtain a product, namely gluconic acid calcium ascorbate. The gluconic acid calcium ascorbate prepared by the method provided by the invention can supplement calcium and VC for a human body at the same time, can be used as an anti-oxidation fresh-keeping agent for supplementing calcium and VC, can be used as a food additive for supplementing calcium and VC, and can be used for treating diseases including osteoporosis, leg cramp, cold, bronchitis and the like.
Description
Technical field
The present invention relates to biochemical industry medicine food field, more particularly to gluconic acid Calcium Ascorbate and its preparation side
Method and application.
Background technology
Calcium Ca is element needed by human, and cation calcium has zhuanggu, healthy tooth, anti-inflammatory, analgesia, maintenance nerve and muscle
NE, the effects such as control anaphylactic disease.
Vitamin C6H8O6The Main Function of (abbreviation VC, also known as vitamin C) is enhance immunity, pre- anti-cancer, heart
Disease, apoplexy, take care of one's teeth with gum etc..The reproducibility that ascorbic acid has can eliminate and cause the nitroso of canceration and cause aging
Free radical, therefore have the effect of sick, antifatigue anti-aging, anticancer, antioxygen, Vitamin C, anti-inflammatory, sterilization, be food, flavouring and
The excellent antioxidant fresh-keeping agent of drink.Ascorbic acid or the main antioxidant of organism, its effect is by antioxidation
And realize.Gluconic acid C6H12O7It is a kind of food acid.
Calcium Ascorbate on world today domestic and international market, its chemical molecular formula is Ca (C6H7O6)2·2H2O, be white or
Slightly yellow crystalline powder, white crystalline powder is unstable perishable for slightly yellow, is dissolved in water in pale yellow solution, Calcium Ascorbate
Price be 120,000 yuan/ton.Although the Calcium Ascorbate can simultaneously supplement calcium and VC, can not be made eye drops, oral liquid and
Injection.And the outer in the market of Now Domestic does not occur gluconic acid Calcium Ascorbate this material also.
The content of the invention
Based on this, it is an object of the present invention to provide gluconic acid Calcium Ascorbate and its preparation method and application, this hair
Bright gluconic acid Calcium Ascorbate can simultaneously for human body supplements calcium and VC, can as the antioxidant fresh-keeping agent replenished the calcium with VC, as
The food additives replenished the calcium with VC, and for treat osteoporosis, have a cramp in the leg, catch a cold, the disease such as bronchitis.
The present invention is realized by scheme in detail below：
Gluconic acid Calcium Ascorbate, its chemical molecular formula is Ca (C6H7O6)(C6H11O7)·H2O, molecular weight is
428.39。
Further, described gluconic acid Calcium Ascorbate, calcic 9.36% by mass percentage, containing ascorbic acid
40.88%, containing gluconic acid 45.56%, containing the crystallization water 4.20%.
Gluconic acid Calcium Ascorbate of the invention, also known as gluconic acid VC calcium, confirm through mass spectrum and chemical analysis are surveyed
Fixed, its chemical molecular formula is Ca (C6H7O6)(C6H11O7)·H2O, molecular weight is 428.39, by mass percentage calcic 9.36%,
Containing ascorbic acid 40.88%, containing gluconic acid 45.56%, containing the crystallization water 4.20%, its purity (medicine food more than 99%
Level), it is white crystalline powder, water-soluble [5.88gCa (C6H7O6)(C6H11O7)·H2O/100ml, 25 DEG C], water is dissolved in nothing
Color solution.
Gluconic acid Calcium Ascorbate of the invention is widely used, can be as the antioxidant fresh-keeping agent replenished the calcium with VC, as benefit
The food additives of calcium and VC, or as zhuanggu health products.The gluconic acid Calcium Ascorbate can be used for treatment sclerotin and dredge
Pine, have a cramp in the leg, catch a cold, the disease such as bronchitis, asthma, pneumonia, lung cancer, hepatitis, liver cancer, hypertension, can be made into (every, tablet
0.2g, 1 to 2 tablets once, three times per day takes), electuary, capsule, oral liquid or injection.
The preparation method of gluconic acid Calcium Ascorbate of the invention, comprises the following steps：
(1) calcium oxide, ascorbic acid and gluconic acid are put into reaction vessel, is chemically reacted；
(2) fully after reaction, drying and processing is carried out to product；
(3) product after drying is cooled to room temperature, obtains product gluconic acid Calcium Ascorbate.
Preparation method of the invention is simple, easy to operate, and chemical reaction can be carried out at normal temperatures, and the reaction time is fast.The system
The cost of Preparation Method synthesis of glucose acid Calcium Ascorbate is roughly equivalent to the 90% of ascorbic acid price.
Further, the chemical reaction of the step (1) is carried out by following chemical equation：
CaO+C6H8O6+C6H12O7=Ca (C6H7O6)(C6H11O7)·H2O。
Further, in the step (1), the mol ratio of calcium oxide, ascorbic acid and gluconic acid is 1:1:1.
Further, the reaction vessel of the step (1) is agitating ball mill, and it is conventional milling apparatus, solid oxygen
Change calcium, ascorbic acid and gluconic acid can in agitating ball mill by it is finely ground, stir and solid state reaction generation grape occur
Saccharic acid Calcium Ascorbate, it is not necessary to use extra solvent, reduces production cost, while reducing the loss of product.
Further, the chemical reaction of the step (1) is carried out at normal temperatures.
Further, the reaction time of the chemical reaction of the step (1) is 30~40min.
Further, the drying and processing of the step (2) is carried out at a temperature of 102~105 DEG C, can accelerate drying efficiency,
Prevent product from decomposing simultaneously.
Gluconic acid Calcium Ascorbate of the present invention can be applicable to medicine food field.
In order to more fully understand and implement, the invention will now be described in detail with reference to the accompanying drawings.
Brief description of the drawings
Fig. 1 is the preparation method flow chart of gluconic acid Calcium Ascorbate of the invention.
Specific embodiment
Fig. 1 is referred to, it is the preparation method flow chart of gluconic acid Calcium Ascorbate of the invention.
Embodiment 1
The preparation method of the present embodiment gluconic acid Calcium Ascorbate, comprises the following steps：
(1) raw material lime powder 56.1g, ascorbic acid powder 176.1g and gluconic acid powder 196.1g are weighed, will
In raw material input agitating ball mill, start agitating ball mill, chemically reacted under normal temperature, chemical equation is：
CaO+C6H8O6+C6H12O7=Ca (C6H7O6)(C6H11O7)·H2O。
(2) fully after reaction 40min, stop agitating ball mill and release product, product is dried at a temperature of 105 DEG C
Dry-cure；
(3) product after drying is cooled to room temperature, is weighed after cooling, obtain product gluconic acid Calcium Ascorbate
419.7g。
(4) by step (3) gained gluconic acid Calcium Ascorbate packed products.
Embodiment 2
The preparation method of the present embodiment gluconic acid Calcium Ascorbate, comprises the following steps：
(1) raw material lime powder 28.0g, ascorbic acid powder 88.1g and gluconic acid powder 98.1g are weighed, by original
In material input agitating ball mill, start agitating ball mill, chemically reacted under normal temperature, chemical equation is：
CaO+C6H8O6+C6H12O7=Ca (C6H7O6)(C6H11O7)·H2O。
(2) fully after reaction 30min, stop agitating ball mill and release product, product is dried at a temperature of 102 DEG C
Dry-cure；
(3) product after drying is cooled to room temperature, is weighed after cooling, obtain product gluconic acid Calcium Ascorbate
212.1g。
(4) by step (3) gained gluconic acid Calcium Ascorbate packed products.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.
Claims (10)
1. gluconic acid Calcium Ascorbate, its chemical molecular formula is Ca (C6H7O6)(C6H11O7)·H2O, molecular weight is 428.39.
2. the gluconic acid Calcium Ascorbate described in claim 1, it is characterised in that：Calcic 9.36%, contains by mass percentage
Ascorbic acid 40.88%, containing gluconic acid 45.56%, containing the crystallization water 4.20%.
3. the preparation method of gluconic acid Calcium Ascorbate, comprises the following steps：
(1) calcium oxide, ascorbic acid and gluconic acid are put into reaction vessel, is chemically reacted；
(2) fully after reaction, drying and processing is carried out to product；
(3) product after drying is cooled to room temperature, obtains product gluconic acid Calcium Ascorbate.
4. the preparation method of gluconic acid Calcium Ascorbate according to claim 3, it is characterised in that：The step (1)
Chemical reaction carried out by following chemical equation：
CaO+C6H8O6+C6H12O7=Ca (C6H7O6)(C6H11O7)·H2O。
5. the preparation method of the gluconic acid Calcium Ascorbate according to any one of claim 3 or 4, it is characterised in that：Institute
State in step (1), the mol ratio of calcium oxide, ascorbic acid and gluconic acid is 1:1:1.
6. the preparation method of the gluconic acid Calcium Ascorbate according to any one of claim 3 or 4, it is characterised in that：Institute
The reaction vessel for stating step (1) is agitating ball mill.
7. the preparation method of the gluconic acid Calcium Ascorbate according to any one of claim 3 or 4, it is characterised in that：Institute
The chemical reaction for stating step (1) is carried out at normal temperatures.
8. the preparation method of the gluconic acid Calcium Ascorbate according to any one of claim 3 or 4, it is characterised in that：Institute
The reaction time for stating the chemical reaction of step (1) is 30~40min.
9. the preparation method of the gluconic acid Calcium Ascorbate according to any one of claim 3 or 4, it is characterised in that：Institute
The drying and processing for stating step (2) is carried out at a temperature of 102~105 DEG C.
10. application of the gluconic acid Calcium Ascorbate described in claim 1 in medicine food field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611240102.6A CN106699706A (en) | 2016-12-28 | 2016-12-28 | Gluconic acid calcium ascorbate as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611240102.6A CN106699706A (en) | 2016-12-28 | 2016-12-28 | Gluconic acid calcium ascorbate as well as preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106699706A true CN106699706A (en) | 2017-05-24 |
Family
ID=58903706
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611240102.6A Pending CN106699706A (en) | 2016-12-28 | 2016-12-28 | Gluconic acid calcium ascorbate as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106699706A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103739579A (en) * | 2013-12-20 | 2014-04-23 | 李玉成 | Citric acid dehydrogenated calcium ascorbate and preparation method and application thereof |
| CN104356101A (en) * | 2014-11-07 | 2015-02-18 | 李玉成 | Calcium acetylsalicylate ascorbate and preparation method thereof |
| EP2884284A1 (en) * | 2013-12-12 | 2015-06-17 | C A Casyso AG | Dry diagnostic reagent |
-
2016
- 2016-12-28 CN CN201611240102.6A patent/CN106699706A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2884284A1 (en) * | 2013-12-12 | 2015-06-17 | C A Casyso AG | Dry diagnostic reagent |
| CN103739579A (en) * | 2013-12-20 | 2014-04-23 | 李玉成 | Citric acid dehydrogenated calcium ascorbate and preparation method and application thereof |
| CN104356101A (en) * | 2014-11-07 | 2015-02-18 | 李玉成 | Calcium acetylsalicylate ascorbate and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| KASSEM, ALY A ET AL.: ""Injectable calcium gluconoascorbate"", 《BULLETIN OF THE FACULTY OF PHARMACY》 * |
| XU ZH ET AL.: ""Combination of vitamin C and zinc gluconate prevented vanadium-induced tight junction leakage of MDCK cell monolayer"", 《JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES》 * |
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Application publication date: 20170524 |