CN106697344A - Ultrasonic vibration type powder trace filling nozzle - Google Patents
Ultrasonic vibration type powder trace filling nozzle Download PDFInfo
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- CN106697344A CN106697344A CN201710038576.0A CN201710038576A CN106697344A CN 106697344 A CN106697344 A CN 106697344A CN 201710038576 A CN201710038576 A CN 201710038576A CN 106697344 A CN106697344 A CN 106697344A
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- powder
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- 239000000843 powder Substances 0.000 title claims abstract description 90
- 239000000463 material Substances 0.000 claims abstract description 17
- 239000000919 ceramic Substances 0.000 claims description 8
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 5
- 239000005297 pyrex Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 28
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 238000013461 design Methods 0.000 abstract description 6
- 210000002345 respiratory system Anatomy 0.000 abstract description 4
- 239000002775 capsule Substances 0.000 abstract description 3
- 238000011002 quantification Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 16
- 239000002245 particle Substances 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000009924 canning Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012827 research and development Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- OBRNDARFFFHCGE-QDSVTUBZSA-N arformoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-QDSVTUBZSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 229960000193 formoterol fumarate Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B1/08—Methods of, or means for, filling the material into the containers or receptacles by vibratory feeders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Quality & Reliability (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an ultrasonic vibration type powder trace filling nozzle which comprises a filling runner and an ultrasonic vibration source installed on the filling runner. The inner diameter of a cylindrical runner of the filling runner is designed to be 6 mm to 10 mm, the inner diameter of an outlet in the lower end of a conical runner is designed to be 0.6 mm to 1.5 mm, the semi-cone angle of the conical runner is designed to be 6 degrees to 20 degrees, and the total height of the cylindrical runner and the conical runner is larger than the height of the cylindrical runner by 10 mm or above. According to the runners in the ultrasonic vibration type powder trace filling nozzle, key parameters and a specific parameter range in the whole runner design are completed, and control over medicament powder trace filling is better facilitated. In addition, due to the study on material selection of the runners, the flow speed of powder in the runners is more stable, and trace filling control is more accurate and effective; and the ultrasonic vibration type powder trace filling nozzle is particularly suitable for achieving precise quantification of trace powder conveying and filling in the production process of respiratory tract dry powder inhalation type medicaments (such as capsules and vesicae) and the like which is smaller than 20 mg per dose.
Description
Technical field
The present invention relates to powder filling equipment, more specifically to a kind of micro filling shower nozzle of ultrasonic vibration formula powder.
Background technology
In pharmaceuticals industry, it is each with production that powder body material is related to medicament research and development as raw material, intermediate, final products
Individual link.To improve the drug absorption of biological effect and human body to poorly water-soluble of medicine, powder granule used in pharmaceutical preparation
Particle diameter is usually as low as micron or nanoscale.But this kind of fine materials can show excessively poor mobility, drug research and development and life
Product causes very big operating technology problem and wastage of material.Wherein, respiratory tract dry powder induction type medicament is used as treatment asthma, slow
Property the PUD D such as obstructive pneumonia effective means, its research and development and production start to be highly valued at home.Dry powder is sucked
The production of agent supervised by strict pharmacy and manufacturer's standard, wherein most challenge is homogeneity between Foradil Aerolizer formoterol fumarate agent
Control.Therefore, a filling important step as influence product quality of medicament powder.The accuracy of filling process decides
Homogeneity between medicine agent.Its high efficiency can solve product, and production cost is high in process of production, and the cycle is long, and wastage of material is tight
The problems such as weight, reduce the energy, the waste of the resource such as material and manpower.For such technical need, people is studied in last century Mo
Member begins to focus on application of the micro Canning Technique of powder in designative species.
At present, the micro Canning Technique of common powder is using pneumatics and volumetric method.Patent US4350049 is 1982
Year describes and pneumatics is combined in powder micro application in transit with volumetric method.But method can not provide successional powder
Body is conveyed, and powder stuffing and transport are alternately accomplished.It is difficult to produce micro- dosage medicament (＜ using the Canning Technique of volumetric method
20 milligrams)；The weighing of filling powder is completed by pre-designed volume quantitative groove, and accuracy receives powder packing density of particle
Real-time change influenceed；Such as need to change filling dosage and need to redesign and change filling apparatus, this undoubtedly increase the time with
Financial cost.And the filling of single powder or powder mixture is can be only done, just must first by these for multicomponent pharmaceutical
Component largely mixes, then carry out again it is filling, can so cause by mixed zone come agent between component it is uneven.In addition, to viscosity
Powder high is also easy to powder blocking occur when carrying out filling, cause low dosage to export or process stands idle.
Gravimetric method is the micro filling solution of another powder.Powder is entered by nozzle discharging under gravity
Enter target position.However, medicament production in superfine powder due to its mobility it is bad, free flow can not be realized under gravity
It is dynamic, it is ensured that the not uniformity of each filling dosage, influence filling accuracy or even product quality.Open source literature J Biomol
Screen, describes filling to realize accurate gravimetric method in 10 (2005) p524-531, bulking system has added instant matter
The weight balancing system in amount iterative feedback loop.The system feeds back instantaneous weight to control shower nozzle valve to open and close by balance
Close powder flowing discharging.Filling accuracy is which enhanced, but also brings process simultaneously and taken and be difficult to be applied to extensive life
The defect of producing line.
Found according to current research, volumetric method can effectively be solved by the micro Canning Technique of powder of vibrational excitation and control
With the existing applied defect of gravimetric method.Its realized using capillary or miniature funnel it is micro transport and it is filling during, it is right
Transport passage to apply to help to encircle power between destruction high viscosity powder agglomeration and particle by the vibration of pulse signal control, trigger powder
Flow freely.Patent GB2472817 describe vibration powder body material it is micro it is filling on application.
Three kinds of delivery pipes of different structure are disclosed in patent GB2472817, as shown in Fig. 1 a~Fig. 1 c, and phase is given
Answer parameter：Minimum 5 millimeters in the horizontal direction of the internal diameter D (disregarding pipe thickness) of upper vertical parts；Outlet aperture d is in water
Square it is 200 microns to 3 millimeters to the maximum upwards；The angle [alpha] of bottom cone inclined-plane and vertical direction is at 5 degree to 45 degree (see Fig. 3).
Water is also described in patent GB2472817 as media transmission ultrasonic activation, therefore Vibration propagation medium
Influence of the property to powder flowing is also a key factor for needing to consider.
But, because above-mentioned patent and open source literature only exist in a research for primary for the micro control technology of powder
Stage, its disclosed above-mentioned parameter is also only a general, wide in range scope, is only suitable to laboratory test, and have not been able into one
Step in-depth study.Because various powder physical property in itself is different, as research finds, above-mentioned design parameter is not only not complete enough
It is whole, and can not really and well realize various powder, particularly such as this kind of fine particle of medicament and poor fluidity, easily
The micro filling control of the high viscosity powder of caking.With the production of respiratory tract dry powder induction type medicament (such as capsule, vesica)
Demand constantly increases, micro to realize in the urgent need to the micro control technology to pharmacy powder is further furtherd investigate
Change powder conveyance and filling real accurate quantification.
The content of the invention
It is micro it is an object of the invention to provide a kind of ultrasonic vibration formula powder for disadvantages mentioned above present in prior art
Filling shower nozzle, the micro filling control of medicament powder is realized by ultrasonic vibration.
To achieve the above object, the present invention is adopted the following technical scheme that：
The micro filling shower nozzle of ultrasonic vibration formula powder, including filling runner and the ultrasonic vibration on filling runner
Source, filling runner includes cylindrical flow and cone cavity, and cylindrical flow is communicated in cone cavity upper end, and cone
Runner upper-end inner diameter is identical with cylindrical flow internal diameter and more than cone cavity lower end exit inside diameter, described cylindrical flow
Internal diameter is designed as 6~10 millimeters, and described cone cavity lower end exit inside diameter is designed as 0.6~1.5 millimeter, described circular cone
The semi-cone angle of shape runner is designed as 6~20 °, and the total height of cylindrical flow and cone cavity is more than cylindrical flow height 10
It is more than millimeter.
Described cylindrical flow lower end is a continuous cambered surface with the inner wall surface of cone cavity upper end connectivity part, should
Cylindrical flow internal diameter of the radius of curvature of cambered surface more than 1.5 times.
Described filling runner is made using the material that light weight, low vibration are damped.
Described filling runner is made using Pyrex.
Described ultrasonic vibration source is arranged on filling runner by fixture, and fixture is cylindrical shape fixture, is used to
Filling runner bottom is set in, described ultrasonic vibration source is attached at cylindrical shape fixture lower surface.
Described ultrasonic vibration source is annular piezoelectric ceramics inverting element.
In the above-mentioned technical solutions, the micro filling shower nozzle of ultrasonic vibration formula powder of the invention has following advantage：
1st, key parameter and specific parameter area in perfect whole runner, are more beneficial for fine particle and mobility
Difference, easily caking, the micro filling control of high-viscosity medicament powder.
2nd, the selection requirements to runner material are proposed, so that runner is to Vibration propagation efficiency high.
3rd, Pyrex are proposed as preferably runner processing material.
4th, a kind of filling nozzle structure of medicament powder of use ultrasonic vibration source is proposed.
Brief description of the drawings
Fig. 1 a~Fig. 1 c are respectively three kinds of structural representations of delivery pipe of prior art；
Fig. 2 is the decomposing schematic representation of the micro filling shower nozzle of ultrasonic vibration formula powder of the invention；
Fig. 3 is the scheme of installation of the micro filling shower nozzle of ultrasonic vibration formula powder of the invention；
Fig. 4 is a kind of structural representation of embodiment of filling runner of the invention；
Fig. 5 is the structural representation of another embodiment of filling runner of the invention；
Fig. 6 is the scheme of installation of filling runner of the invention and ultrasonic vibration source.
Specific embodiment
Technical scheme is further illustrated with reference to the accompanying drawings and examples.
The micro filling shower nozzle of ultrasonic vibration formula powder of the invention as shown in Figure 2 to 3, mainly includes the shower nozzle of circular tube shaped
Housing 10, the filling runner 11 being fixedly arranged in nozzle housing 10 and ultrasonic vibration source 14, filling runner 11 can be using such as Fig. 4, Fig. 5
Two kinds of multi-forms, Fig. 4 is body form, and Fig. 5 is cavity form, certainly can also be using other forms.Also, the present invention
The structure of filling runner 11 be with patent GB2472817 something in common, equally also include cylindrical flow 1 and cone cavity
2, cylindrical flow 1 is communicated in the upper end of cone cavity 2, and the upper-end inner diameter of cone cavity 2 is identical with the internal diameter of cylindrical flow 1
And more than the bottom diameter of cone cavity 2.
Difference is that the present invention is calculated repeatedly by further in-depth study and repeatedly, experiment finds, the filling
Filling the key parameter of runner 11 should include the internal diameter D of cylindrical flow 1, the lower end exit inside diameter D of cone cavity 2o, cone stream
The semi-cone angle α in road 2 and the overall height H of cylindrical flow 1 and cone cavity 2, aforementioned four parameter are indispensable, each parameter
Specific span is as follows：The described internal diameter D of cylindrical flow 1 is designed as 6~10 millimeters, the described lower end of cone cavity 2
Exit inside diameter Do0.6~1.5 millimeter is designed as, the semi-cone angle α of described cone cavity 2 is designed as 6~20 °, cylindrical flow
The overall height H of road and cone cavity should be greater than cylindrical flow height more than 10 millimeters, with meet little particle and poor fluidity,
Easy caking, the micro filling control of high-viscosity medicament powder.
Herein it should be noted that parameter DoSpan be common by powder granule physical property and external vibration parameter
Determine.If the powder in being filled in runner under gravitational field can be by the minimum-value aperture of the spontaneous outflow of the circular port of bottom
Dc, as the aperture D for processingo≥Dc, filling powder in backward runner is blocked into the hole with object, after inserting certain altitude, go
Fall to get lodged in the object of orifice position, now powder can be flowed downward out in runner；Conversely, as the aperture D for processingo＜ Dc, repeat
Operation above, powder is still in original place in runner after tamper is removed, and will not flow downward out.
Under effect of vibration, it is somebody's turn to do " critical value " and is changed into Dc,v, it defines method and DcIt is similar.Dc,vLess than Dc, therefore in order that
Powder is flowed out and static under state without friction only under effect of vibration, therefore the selection of rational processing aperture should be abided by the present invention
Follow with lower inequality：
D(c,v)<Do<Dc
Determine through experiment is final, DoIt is designed as 0.6~1.5 millimeter.
And the determination of semi-cone angle α is increasingly complex, when astringent runner constitutes a conical lower portion, this cone angle is to internal powder
Stream moves important influence.In runner in addition to being slided between generation particle, particle can also be slided powder along runner wall
It is dynamic.When powder reaches internal yield boundary, powder granule is slided between there is particle；When wall surrender boundary is reached, particle
Betide the relative slip between wall.Maximum tapered runner half-angle α max needed for angle of wall friction w flows with powder are relevant.
So, for the value for enabling powder freely to flow out astringent runner half-angle should be less than " critical value " α max.It is final really through experiment
Fixed, α is designed as 6~20 °.
And 1 internal diameter D of circle straight pipe type runner is bigger, powder flowing resistance is smaller, and mass flow is more stable.But D increases can add
Big runner overall dimensions, are unfavorable for the Miniaturization Design of whole bulking system.Determine through experiment is final, D is designed as 6~10 millis
Rice.
Because the mobility of pharmacy pulvis is generally poor, during being flowed from cylindrical flow to cone cavity,
Easily assemble in junction, influence the flowing of follow-up powder, therefore the present invention have also been devised following structure：In described circle
The lower end of pipe running system 1 is a continuous cambered surface, the radius of curvature of the cambered surface with the inner wall surface of the upper end connectivity part of cone cavity 2
R is bigger, and powder flowing resistance is smaller, and mass flow is more stable, therefore determines by the way that experiment is final, by the radius of curvature of the cambered surface
R is designed as the cylindrical flow internal diameter more than 1.5 times.By above-mentioned cambered surface transition, pharmacy pulvis can be avoided poly- herein
Collection phenomenon, it is ensured that the homogeneity of the flow velocity of pharmacy pulvis, is more conducive to micro accurate filling control.
The material selection of above-mentioned filling runner 11 need to follow it is following some：Light weight, low vibration damping.
Accordingly, as one embodiment, described filling runner 11 can be made using materials such as Pyrex.
Incorporated by reference to shown in Fig. 2,3,6, described ultrasonic vibration source 14 is fixed on filling runner 11 by fixture 13.Make
It is one embodiment, fixture 13 is cylindrical shape fixture, is used to be set in filling runner bottom, and described ultrasonic vibration source is
Annular piezoelectric ceramics inverting element, is attached at cylindrical shape fixture lower surface, to realize being arranged on filling runner 11.When
So, can also be using other shapes and the fixture and piezoelectric ceramics inverting element of structure.The frequency of piezoelectric ceramics inverting element
In the range of 30000 hertz to 50000 hertz, the electrode polarization direction of piezoelectric ceramics inverting element is to be perpendicularly oriented to water passage surface
Direction, this side up, piezoelectric ceramics inverting element is produced under 30000 hertz of pulse voltages to 50000 hertz frequencies
Dither.In this way, the ultrasonic vibration and stopping of piezoelectric ceramics inverting element are controlled by pulse voltage signal, to realize control
Filling (material falls) of filling shower nozzle and stop filling.
In addition, the described upper and lower ends of nozzle housing 10 are additionally provided with dismountable upper and lower cover 15,16, by upper lid of outwarding winding
15, powder charging can be carried out in runner；When outward winding lower cover 16 after, can carry out filling.
Filling embodiment is carried out to various medicaments powder using the micro filling shower nozzle of ultrasonic vibration formula powder of the invention
It is as follows：
Shown in above-described embodiment and be applied to 200 microns to the medicament powder in 30 micron particles particle size ranges, runner
Parameter has different medicament powder discharge rate in the runner being motivated by ultrasound and discharging precision (relative standard deviation between agent)
Influence.In selected runner parameter area, it is possible to achieve milligram ammonia (<100 milli Grams Per Seconds) medicament powder it is filling and be less than
Error between 5% agent, minimum error requirement of the error much smaller than homogeneity between industry agent in embodiment.
In sum, using disclosed in the micro filling shower nozzle of ultrasonic vibration formula powder of the invention and patent GB2472817
Delivery pipe compare, with following multiple advantages：
1st, further further investigation, improves runner design, increased cylindrical flow and cone cavity internal diameter,
The parameters such as highly, semi-cone angle, the radius of connectivity part cambered surface so that whole flow passage structure parameter is more perfect, and by repeatedly anti-
Retrial is tested and calculating obtains each parameter more specifically number range, so as to be more beneficial for fine particle and poor fluidity, easily
Caking, the micro filling control of high-viscosity medicament powder.
2nd, the selection requirements to runner material are proposed so that runner can be more beneficial for it is micro it is filling it is accurate,
Effectively control.
3rd, Pyrex are proposed as preferably runner processing material.
4th, can be in glass channel outer surface mark just like the volume markings that precision is 1 milliliter, the convenient powder read in runner
Material surplus.
5th, the micro filling shower nozzle of ultrasonic vibration formula powder of the invention can be widely used in several grams every dose, a diameter of number milli
The micro- dosage medicament filling control of medicament of rice, is particularly well-suited to such as respiratory tract dry powder induction type medicament of 20 milligrams every dose of ＜
Milligram ammonia powder conveyance and filling accurate quantification are realized in the production process of (such as capsule, vesica), especially for tiny
The high viscosity powder of grain (especially less than 10 microns) and poor fluidity easily caking, helps to improve product matter in medicament is produced
Amount, reduces cost reduces time and the complexity of pharmacy.Certainly, the present disclosure additionally applies for other classes in addition to medicament powder
Like the micro filling control of powder of physical property.
8th, employ and there is visibly different vibration source structure (piezoelectric energy-conversion element) and vibration source assembling with GB patents
A kind of mode, split type ultrasonic vibration source 14 of brand-new design, drives the filling runner ultrasound to shake by the transmission of fixture
It is dynamic, to reach the control mode of more preferably dither, so that micro filling design comes true.
Those of ordinary skill in the art it should be appreciated that the embodiment of the above be intended merely to explanation the present invention,
And be not used as being limitation of the invention, as long as in spirit of the invention, the change to embodiment described above
Change, modification will all fall in the range of claims of the present invention.
Claims (7)
1. the micro filling shower nozzle of a kind of ultrasonic vibration formula powder, it is characterised in that：Including filling runner and installed in filling runner
On ultrasonic vibration source, filling runner includes cylindrical flow and cone cavity, and cylindrical flow is communicated in cone cavity
Upper end, and cone cavity upper-end inner diameter is identical with cylindrical flow internal diameter and more than cone cavity lower end exit inside diameter, institute
The cylindrical flow internal diameter stated is designed as 6~10 millimeters, and described cone cavity lower end exit inside diameter is designed as 0.6~1.5
Millimeter, the semi-cone angle of described cone cavity is designed as 6~20 °, and the total height of cylindrical flow and cone cavity is more than
More than 10 millimeters of cylindrical flow height.
2. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 1, it is characterised in that：
Described cylindrical flow lower end is a continuous cambered surface with the inner wall surface of cone cavity upper end connectivity part.
3. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 2, it is characterised in that：
Cylindrical flow internal diameter of the radius of curvature of described cambered surface more than 1.5 times.
4. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 1, it is characterised in that：
Described filling runner is made using the material that light weight, low vibration are damped.
5. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 4, it is characterised in that：
Described filling runner is made using Pyrex.
6. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 1, it is characterised in that：
Described ultrasonic vibration source is arranged on filling runner by fixture, and fixture is cylindrical shape fixture, is used to be arranged
In filling runner bottom, described ultrasonic vibration source is attached at cylindrical shape fixture lower surface.
7. the micro filling shower nozzle of ultrasonic vibration formula powder as described in claim 6, it is characterised in that：Described ultrasonic vibration
Source is annular piezoelectric ceramics inverting element.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038576.0A CN106697344B (en) | 2017-01-19 | 2017-01-19 | A kind of micro filling spray head of ultrasonic vibration formula powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038576.0A CN106697344B (en) | 2017-01-19 | 2017-01-19 | A kind of micro filling spray head of ultrasonic vibration formula powder |
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| CN106697344A true CN106697344A (en) | 2017-05-24 |
| CN106697344B CN106697344B (en) | 2019-06-07 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350049A (en) * | 1979-11-09 | 1982-09-21 | Boehringer Ingelheim Gmbh | Device and process for drawing off very small quantities of powder |
| EP0282958A1 (en) * | 1987-03-19 | 1988-09-21 | Boehringer Ingelheim Zentrale Gmbh | Process and device for dosing powders |
| WO2008003942A2 (en) * | 2006-07-01 | 2008-01-10 | The University Of Manchester | Powder delivery apparatus |
| GB2472817A (en) * | 2009-08-19 | 2011-02-23 | Queen Mary & Westfield College | Powder dispenser with permanently-open linear-taper nozzle operated by vibration |
| CN203497769U (en) * | 2013-08-28 | 2014-03-26 | 厦门泰益新洁净科技有限公司 | Supplying device of powdery materials |
| WO2014111718A1 (en) * | 2013-01-17 | 2014-07-24 | Varydose Limited | Apparatus and method for dispensing powders |
| CN205738155U (en) * | 2016-07-01 | 2016-11-30 | 河北工业大学 | A kind of rotating micro powder filling device |
-
2017
- 2017-01-19 CN CN201710038576.0A patent/CN106697344B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350049A (en) * | 1979-11-09 | 1982-09-21 | Boehringer Ingelheim Gmbh | Device and process for drawing off very small quantities of powder |
| EP0282958A1 (en) * | 1987-03-19 | 1988-09-21 | Boehringer Ingelheim Zentrale Gmbh | Process and device for dosing powders |
| WO2008003942A2 (en) * | 2006-07-01 | 2008-01-10 | The University Of Manchester | Powder delivery apparatus |
| GB2472817A (en) * | 2009-08-19 | 2011-02-23 | Queen Mary & Westfield College | Powder dispenser with permanently-open linear-taper nozzle operated by vibration |
| WO2014111718A1 (en) * | 2013-01-17 | 2014-07-24 | Varydose Limited | Apparatus and method for dispensing powders |
| CN203497769U (en) * | 2013-08-28 | 2014-03-26 | 厦门泰益新洁净科技有限公司 | Supplying device of powdery materials |
| CN205738155U (en) * | 2016-07-01 | 2016-11-30 | 河北工业大学 | A kind of rotating micro powder filling device |
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| CN106697344B (en) | 2019-06-07 |
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Address after: Room 301, Room 3, Phase 1, Hangzhou Future Research Park, No. 7 Longtan Road, Cangqian Street, Yuhang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Changxi Pharmaceutical Co.,Ltd. Address before: 310026 Room 226, Building 3, No. 1, Luting Road, Cangqian Street, Yuhang District, Hangzhou City, Zhejiang Province Applicant before: HANGZHOU CHANGXI MEDICAL DEVICES CO.,LTD. |
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Inventor after: Li Zongqi Inventor after: Chen Lan Inventor after: Chen Donghao Inventor after: Huang Peng Inventor after: Sun Meisheng Inventor before: Li Zongqi Inventor before: Chen Lan Inventor before: Chen Donghao Inventor before: Huang Peng Inventor before: Sun Meisheng |
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Denomination of invention: Ultrasonic vibration type powder trace filling nozzle Effective date of registration: 20190726 Granted publication date: 20190607 Pledgee: Bank of Hangzhou Limited by Share Ltd. science and Technology Branch Pledgor: Hangzhou Changxi Pharmaceutical Co.,Ltd. Registration number: 2019330000214 |
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Date of cancellation: 20210926 Granted publication date: 20190607 Pledgee: Bank of Hangzhou Limited by Share Ltd. science and Technology Branch Pledgor: Hangzhou Changxi Pharmaceutical Co.,Ltd. Registration number: 2019330000214 |
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Address after: Room 501, Building 18, Yinhai Science and Technology Innovation Center, No. 501 Fucheng Road, Xiasha Street, Qiantang District, Hangzhou City, Zhejiang Province, 310020 Patentee after: Hangzhou Changxi Pharmaceutical Co.,Ltd. Address before: Room 301, Room 3, Phase 1, Hangzhou Future Research Park, No. 7 Longtan Road, Cangqian Street, Yuhang District, Hangzhou City, Zhejiang Province Patentee before: Hangzhou Changxi Pharmaceutical Co.,Ltd. |