CN106628283B - A kind of micro filling runner of powder - Google Patents
A kind of micro filling runner of powder Download PDFInfo
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- CN106628283B CN106628283B CN201710038579.4A CN201710038579A CN106628283B CN 106628283 B CN106628283 B CN 106628283B CN 201710038579 A CN201710038579 A CN 201710038579A CN 106628283 B CN106628283 B CN 106628283B
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- powder
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- cylindrical flow
- filling
- cone cavity
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- 239000000843 powder Substances 0.000 title claims abstract description 81
- 239000000463 material Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 13
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
- 239000005297 pyrex Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 23
- 238000013461 design Methods 0.000 abstract description 4
- 238000011160 research Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 17
- 239000002245 particle Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 238000009924 canning Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 238000005054 agglomeration Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012827 research and development Methods 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- OBRNDARFFFHCGE-QDSVTUBZSA-N arformoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-QDSVTUBZSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 229960000193 formoterol fumarate Drugs 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B1/08—Methods of, or means for, filling the material into the containers or receptacles by vibratory feeders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Quality & Reliability (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of micro filling runners of powder, including the cylindrical flow and cone cavity being connected up and down, cylindrical flow internal diameter is designed as 6~10 millimeters, cone cavity lower end exit inside diameter is designed as 0.6~1.5 millimeter, the semi-cone angle of the cone cavity is designed as 6~20 °, and the total height of cylindrical flow and cone cavity is greater than 10 millimeters of cylindrical flow height or more.Key parameter and specific parameter area in the perfect entire runner design of runner of the invention, are more advantageous to the micro filling control of medicament powder.Also, by the research to runner selection, so that the flow velocity of powder is more stable in runner, so that micro filling control is more accurate, effective.
Description
Technical field
The present invention relates to powder filling equipment, more specifically to a kind of micro filling runner of powder.
Background technique
In pharmaceuticals industry, powder body material is related to each of medicament research and development and production as raw material, intermediate, final products
A link.For improve drug biological effect and human body to the drug absorption of poorly water-soluble, powder granule used in pharmaceutical preparation
Partial size is usually as low as micron or nanoscale.But this kind of fine materials can show excessively poor mobility, give medicament research and development and life
Production causes very big operating technology problem and wastage of material.Wherein, respiratory tract dry powder induction type medicament is as treatment asthma, slow
Property the pulmonary diseases such as obstructive pneumonia effective means, research and development and production start to be highly valued at home.Dry powder sucking
The production of agent is supervised by stringent pharmacy and manufacturer's standard, wherein most challenging is between homogeneity Foradil Aerolizer formoterol fumarate agent
Control.Therefore, the filling of medicament powder becomes an important link for influencing product quality.The accuracy of filling process decides
Homogeneity between drug agent.Its high efficiency can solve product high production cost in process of production, and the period is long, and wastage of material is tight
The problems such as weight, reduces the energy, the waste of the resources such as material and manpower.For such technical need, people is studied in last century end
Member begins to focus on the micro Canning Technique of powder in the application of designative species.
Currently, the micro Canning Technique of common powder is using pneumatics and volumetric method.Patent US4350049 is 1982
It describes in year and pneumatics and volumetric method is incorporated in the micro application in transit of powder.But method cannot provide successional powder
Body conveying, powder stuffing and transport are alternately accomplished.It is difficult to produce micro- dosage medicament (< using the Canning Technique of volumetric method
20 milligrams)；The weighing of filling powder is completed by pre-designed volume quantitative slot, and accuracy is by powder packing density of particle
Real-time change influenced；Need to redesign replacement filling apparatus if you need to change filling dosage, this undoubtedly increase the time with
Economic cost.And can be only done the filling of single powder or powder mixture, it just must be first by these for multicomponent pharmaceutical
Component largely mixes, and then carries out again filling, will lead to so uneven by component between mixing bring agent.In addition, to viscosity
Also it is easy to appear powder blockings when high powder carries out filling, lead to low dosage output or process stands idle.
Gravimetric method is the micro filling solution of another powder.Powder pass through under gravity nozzle discharging into
Enter target position.However, medicament production in superfine powder due to its mobility it is bad, can not achieve free flow under the effect of gravity
It is dynamic, it can not guarantee the consistency of each filling dosage, influence filling accuracy or even product quality.Open source literature J Biomol
It is described in Screen, 10 (2005) p524-531 to realize that accurate gravimetric method is filling, bulking system has added instant matter
Measure the weight balancing system in iterative feedback circuit.The system feeds back instantaneous weight by balance to control spray head valve to open and close
Close powder flowing discharging.Filling accuracy is improved in this way, but is also brought process time-consuming simultaneously and be difficult to be suitable for extensive raw
The defect of producing line.
Root the latest researches have found that, by vibrational excitation and control the micro Canning Technique of powder can effectively solve volumetric method
With the existing applied defect of gravimetric method.It is right during transporting using capillary or the realization of miniature funnel are micro and is filling
Transporting channel application is facilitated between destruction high viscosity powder agglomeration and particle to encircle power by the vibration that pulse signal controls, and causes powder
It flows freely.Patent GB2472817 describe vibration powder body material it is micro it is filling on application.
Patent GB2472817 discloses the delivery pipe of three kinds of different structures, as shown in Fig. 1 a~Fig. 1 c, and gives corresponding
Parameter: minimum 5 millimeters in the horizontal direction of the internal diameter D (disregarding pipe thickness) of upper vertical parts；Outlet aperture d is in level
It is up to 200 microns to 3 millimeters on direction, it is preferable that be up to 2 millimeters, most preferably, be up to 1 millimeter；Lower part cone inclined-plane
Angle [alpha] with vertical direction is at 5 degree to 45 degree (see Fig. 3).
Water is also described in patent GB2472817 as medium and propagates ultrasonic activation, therefore Vibration propagation medium
Influence of the property to powder flowing is also a key factor in need of consideration.
But since above-mentioned patent and open source literature only exist in a primary research for the micro control technology of powder
Stage, disclosed above-mentioned parameter are also only a general, wide in range ranges, are only suitable for laboratory test, and have not been able into one
Walk in-depth study.Since the physical property of various powder itself is different, with the study found that above-mentioned design parameter is not only not complete enough
It is whole, and can not really and well realize various powder, especially such as this kind of fine particle of medicament and poor fluidity, easily
The micro filling control of the high viscosity powder of agglomeration.With the production of respiratory tract dry powder induction type medicament (such as capsule, vesica)
Demand constantly increases, and there is an urgent need to the micro control technologies to pharmacy powder further to be furtherd investigate, micro to realize
Change powder conveyance and filling real accurate quantification.
Summary of the invention
For disadvantages mentioned above existing in the prior art, the object of the present invention is to provide a kind of micro filling runner of powder,
The micro filling control of medicament powder can be advantageously implemented.
To achieve the above object, the present invention adopts the following technical scheme:
The micro filling runner of the powder, including cylindrical flow and cone cavity, cylindrical flow are connected to cone
Runner upper end, and cone cavity upper-end inner diameter is identical as cylindrical flow internal diameter and is greater than in the outlet of cone cavity lower end
Diameter, the cylindrical flow internal diameter are designed as 6~10 millimeters, and the cone cavity lower end exit inside diameter is designed as 0.6
~1.5 millimeters, the semi-cone angle of the cone cavity is designed as 6~20 °, the total height of cylindrical flow and cone cavity
Greater than 10 millimeters of cylindrical flow height or more.
The inner wall surface of the cylindrical flow lower end and cone cavity upper end connectivity part is a continuous cambered surface.
The radius of curvature of the cambered surface is greater than 1.5 times of cylindrical flow internal diameter.
The material production that the filling runner is damped using light weight, low vibration.
The filling runner is made of Pyrex.
In the above-mentioned technical solutions, the micro filling runner of powder of the invention has several advantages that
1, key parameter and specific parameter area in perfect entire runner, are more advantageous to the micro filling control of powder
System.
2, the selection requirements to runner material are proposed, so that runner is high-efficient to Vibration propagation；Transparent material
Pyrex runner can be convenient the powder surplus read in runner by surface volume scale.
3, Pyrex are proposed as preferable runner processing material.
Detailed description of the invention
Fig. 1 a~Fig. 1 c is the structural schematic diagram of three kinds of delivery pipes of the prior art respectively；
Fig. 2 is a kind of structural schematic diagram of embodiment of the micro filling runner of powder of the invention；
Fig. 3 is the structural schematic diagram of another embodiment of filling runner of the invention.
Specific embodiment
Technical solution of the present invention is further illustrated with reference to the accompanying drawings and examples.
The micro filling runner of powder of the invention mainly applies in the micro filling spray head of powder or other mechanisms, passes through
The movement of powder in runner is controlled with the mode that vibration combines, it is micro filling to realize.It please refers to shown in Fig. 2~Fig. 3, schemes
2 and Fig. 3 is respectively two kinds of different forms of filling runner of the invention, and Fig. 2 is tube body form, and Fig. 3 is cavity form, certainly also
It can be using other forms.Also, filling flow passage structure of the invention is with patent GB2472817 something in common, equally
It also include cylindrical flow 1 and cone cavity 2, cylindrical flow 1 is connected to 2 upper end of cone cavity, and cone cavity 2
Upper-end inner diameter is identical as 1 internal diameter of cylindrical flow and is greater than 2 bottom diameter of cone cavity.
The difference is that the present invention calculates repeatedly by further in-depth study and repeatedly, tests discovery, the filling
The key parameter for filling runner should include 1 internal diameter D of cylindrical flow, 2 lower end exit inside diameter D of cone cavityo, cone cavity
2 semi-cone angle α and the overall height H of cylindrical flow 1 and cone cavity 2, aforementioned four parameter is indispensable, the tool of each parameter
Body value range is as follows: the 1 internal diameter D of cylindrical flow is designed as 6~10 millimeters, brings out under the cone cavity 2
Mouth internal diameter DoIt is designed as 0.6~1.5 millimeter, the semi-cone angle α of the cone cavity 2 is designed as 6~20 °, cylindrical flow
Should be greater than 10 millimeters of cylindrical flow height or more with the overall height H of cone cavity, with meet fine particle and poor fluidity,
Easily agglomeration, high viscosity physical property medicament powder it is micro filling.
It should be noted that parameter DoValue range be common by powder granule physical property and external vibration parameter
It determines.If the powder being filled in runner under gravitational field can be by the minimum-value aperture of the spontaneous outflow of round hole of bottom end
Dc, as the aperture D processedo≥Dc, gone after inserting certain altitude after being blocked the hole with object to filling powder in runner
Fall to get lodged in the object of orifice position, runner inner powder cognition flows downward out at this time；Conversely, as the aperture D processedo< Dc, repeat
Operation above, powder is still in original place in runner after removing tamper, will not flow downward out.
Under effect of vibration (mechanical/ultrasound), being somebody's turn to do " critical value " becomes Dc,v, define method and DcIt is similar.Dc,vIt is less than
Dc, therefore in order to flow out powder only under effect of vibration and under state without friction it is static, therefore in the present invention reasonably plus
The selection of work aperture should be followed with lower inequality:
D(c,v)<Do<Dc
Tested final determining, DoIt is designed as 0.6~1.5 millimeter.
And the determination of semi-cone angle α is increasingly complex, when astringent runner constitutes a conical lower portion, this cone angle is to internal powder
Stream is dynamic important influence.For powder in runner other than sliding between particle occurs, particle can also be sliding along runner wall surface
It is dynamic.When powder reaches internal yield boundary, powder granule occurs to slide between particle；When reaching wall surface surrender boundary, particle
Betide the opposite sliding between wall surface.Maximum tapered runner half-angle α max needed for powder flowing occurs for angle of wall friction w is related.
So should be less than " critical value " α max for the value for enabling powder freely to flow out astringent runner half-angle.It is tested final true
Fixed, α is designed as 6~20 °.
And justify that 1 internal diameter D of straight pipe type runner is bigger, and powder flowing resistance is smaller, mass flow is more stable.But D increase can add
Big runner overall dimensions, are unfavorable for the Miniaturization Design of entire bulking system.It is finally determined through testing, D is designed as 6~10 millis
Rice.
Since the mobility of pharmacy pulvis is usually poor, during being flowed from cylindrical flow to cone cavity,
Easily assemble in junction, influences the flowing of subsequent powder, therefore the present invention has also been devised with flowering structure: the cylinder
The inner wall surface of 1 lower end of shape runner and 2 upper end connectivity part of cone cavity is a continuous cambered surface, the radius of curvature R of the cambered surface
Bigger, powder flowing resistance is smaller, and mass flow is more stable, therefore determines by the way that experiment is final, by the radius of curvature R of the cambered surface
It is designed as the cylindrical flow internal diameter greater than 1.5 times.By above-mentioned cambered surface transition, the aggregation of pharmacy pulvis here can be avoided
Phenomenon guarantees the homogeneity of the flow velocity of pharmacy pulvis, is more conducive to micro accurate filling control.
The material selection of above-mentioned filling runner need to follow the following: light weight, low vibration damping.
Therefore, as one embodiment, the production of the materials such as Pyrex is can be used in the filling runner, using above-mentioned material
The effect of material is preferable.
It is shown in above-described embodiment applied to 200 microns to the powder in 30 micron particles particle size ranges, runner parameter
There is different influences between medicament powder discharge rate in the runner of ultrasonic action from discharging precision (relative standard deviation agent).
In selected runner parameter area, filling and less than 5% the agent of medicament powder of milligram ammonia (< 100 milli Grams Per Second) may be implemented
Between error, the minimum error requirement of error in embodiment much smaller than homogeneity between industry agent.And use the ginseng other than the present invention
The ultrasonic activation comparative example 1-5 that number carries out, can exist: 1, outlet obstruction cannot form stable outflow；2, overflow is generated, is led
Cause flow velocity uncontrollable；3, the defects of relative standard deviation is big, the medicament powder that can not achieve at all truly are micro accurate
Fill operations.
In conclusion using the micro filling runner of powder and delivery pipe phase disclosed in patent GB2472817 of the invention
Than having the advantages that following multiple:
1, further further investigation, improves runner design, increase cylindrical flow and cone cavity internal diameter,
Highly, semi-cone angle, the parameters such as radius of connectivity part cambered surface, so that entire flow passage structure parameter is more perfect, and by repeatedly anti-
Retrial is tested and calculating obtains each parameter more specifically numberical range, to be more advantageous to the micro filling control of powder.
2, the selection requirements to runner material are proposed so that runner can be more advantageous to it is micro it is filling it is accurate,
Effectively control.
3, Pyrex are proposed as preferable runner processing material.
4, the volume markings for being 1 milliliter just like precision can be marked in glass channel outer surface, the powder in convenient reading runner
Expect surplus.
5, the medicament that the micro filling runner of powder of the invention can be widely used in several grams every dose, diameter is several millimeters is micro-
Dosage medicament filling control, especially suitable for 50 milligrams every dose of < of such as respiratory tract dry powder induction type medicament (such as capsule, vesica
Deng) production process in realize milligram ammonia powder conveyance and filling accurate quantification, (especially less than especially for fine particle
10 microns) and the high viscosity powder that easily agglomerates of poor fluidity, help to improve product quality in medicament production, reduce cost,
Reduce time and the complexity of pharmacy.Certainly, the present disclosure additionally applies for the powders of other similar physical property in addition to medicament powder
Micro filling control.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen within the scope of claims of the present invention.
Claims (3)
1. a kind of micro filling runner of powder, including cylindrical flow and cone cavity, cylindrical flow are connected to cone
Runner upper end, and cone cavity upper-end inner diameter is identical as cylindrical flow internal diameter and is greater than in the outlet of cone cavity lower end
Diameter, it is characterised in that:
The cylindrical flow internal diameter is designed as 6~10 millimeters, and the cone cavity lower end exit inside diameter is designed as 0.6
~1.5 millimeters, the semi-cone angle of the cone cavity is designed as 6~20 °, the total height of cylindrical flow and cone cavity
And the difference of cylindrical flow height is at 10 millimeters or more；
The inner wall surface of the cylindrical flow lower end and cone cavity upper end connectivity part is a continuous cambered surface；
The radius of curvature of the cambered surface is greater than 1.5 times of cylindrical flow internal diameter.
2. the micro filling runner of powder as described in claim 1, it is characterised in that:
The material production that the filling runner is damped using light weight, low vibration.
3. the micro filling runner of powder as described in claim 1, it is characterised in that:
The filling runner is made of Pyrex.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038579.4A CN106628283B (en) | 2017-01-19 | 2017-01-19 | A kind of micro filling runner of powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710038579.4A CN106628283B (en) | 2017-01-19 | 2017-01-19 | A kind of micro filling runner of powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106628283A CN106628283A (en) | 2017-05-10 |
| CN106628283B true CN106628283B (en) | 2019-06-04 |
Family
ID=58840823
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710038579.4A Active CN106628283B (en) | 2017-01-19 | 2017-01-19 | A kind of micro filling runner of powder |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350049A (en) * | 1979-11-09 | 1982-09-21 | Boehringer Ingelheim Gmbh | Device and process for drawing off very small quantities of powder |
| EP0282958A1 (en) * | 1987-03-19 | 1988-09-21 | Boehringer Ingelheim Zentrale Gmbh | Process and device for dosing powders |
| WO2008003942A2 (en) * | 2006-07-01 | 2008-01-10 | The University Of Manchester | Powder delivery apparatus |
| GB2472817A (en) * | 2009-08-19 | 2011-02-23 | Queen Mary & Westfield College | Powder dispenser with permanently-open linear-taper nozzle operated by vibration |
| CN203497769U (en) * | 2013-08-28 | 2014-03-26 | 厦门泰益新洁净科技有限公司 | Supplying device of powdery materials |
| WO2014111718A1 (en) * | 2013-01-17 | 2014-07-24 | Varydose Limited | Apparatus and method for dispensing powders |
| CN205738155U (en) * | 2016-07-01 | 2016-11-30 | 河北工业大学 | A kind of rotating micro powder filling device |
-
2017
- 2017-01-19 CN CN201710038579.4A patent/CN106628283B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350049A (en) * | 1979-11-09 | 1982-09-21 | Boehringer Ingelheim Gmbh | Device and process for drawing off very small quantities of powder |
| EP0282958A1 (en) * | 1987-03-19 | 1988-09-21 | Boehringer Ingelheim Zentrale Gmbh | Process and device for dosing powders |
| WO2008003942A2 (en) * | 2006-07-01 | 2008-01-10 | The University Of Manchester | Powder delivery apparatus |
| GB2472817A (en) * | 2009-08-19 | 2011-02-23 | Queen Mary & Westfield College | Powder dispenser with permanently-open linear-taper nozzle operated by vibration |
| WO2014111718A1 (en) * | 2013-01-17 | 2014-07-24 | Varydose Limited | Apparatus and method for dispensing powders |
| CN203497769U (en) * | 2013-08-28 | 2014-03-26 | 厦门泰益新洁净科技有限公司 | Supplying device of powdery materials |
| CN205738155U (en) * | 2016-07-01 | 2016-11-30 | 河北工业大学 | A kind of rotating micro powder filling device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106628283A (en) | 2017-05-10 |
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