CN106694065A - Micro-flow control liquid or air bubble detection device and method based on solid-liquid friction - Google Patents
Micro-flow control liquid or air bubble detection device and method based on solid-liquid friction Download PDFInfo
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- CN106694065A CN106694065A CN201611074146.6A CN201611074146A CN106694065A CN 106694065 A CN106694065 A CN 106694065A CN 201611074146 A CN201611074146 A CN 201611074146A CN 106694065 A CN106694065 A CN 106694065A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
Abstract
The invention provides micro-flow control liquid or air bubble detection device and method based on solid-liquid friction. The micro-flow control liquid or air bubble detection device comprises a substrate material, an electrode array, an insulated hydrophobic material, a micro-flow control channel supporting material and a micro-flow control channel in a micro-flow control chip; the electrode array is positioned at the upper part of the substrate material and is used for inducing solid-liquid friction electrification; the insulated hydrophobic material is positioned at the upper part of the electrode array, is used for inducing liquid friction electrification and plays an insulating role; the micro-flow control channel is formed above the insulated hydrophobic material and is used for guiding liquid to flow through the insulated hydrophobic material. A solid-liquid friction electrification principle is utilized for detecting the flowing of liquid or air bubbles in the micro-flow control channel, the electrolyte concentration and other information; and the micro-flow control liquid or air bubble detection device has the advantages of being free from external power supply, simple in structure, easy to process and prepare, easy to integrate with an existing micro-flow control chip, and the like. With the adoption of the design of array type comb electrodes, the difference between the liquid and the air bubbles as well as the liquid flow direction can be detected, and the liquid flow velocity is calculated.
Description
Technical field
The present invention relates to micro fluidic chip technical field, more particularly to a kind of micro-fluidic liquid based on solid-liquid friction or
Bubble detection device and method.
Background technology
Micro-fluidic chip is a kind of highly integrated chip, and it can realize biological, chemistry, the sample system of medical analysis process
The full automatic working of the basic operations such as standby, reaction, separation, detection and analysis.This chip using microfluidic channel formed network,
Run through whole system using liquid, so as to may replace the various operations that general chemistry or biology laboratory are accomplished manually.It is micro-fluidic
Scale that the sharpest edges of chip are various functional units on overall controllable micro chip is integrated, good fusion so that
Micro-fluidic chip turns into the important technology of following biochemical analysis.And realize that the basis of extensive handling liquids controllable reaction is right
The real-time monitoring of the micro-fluidic interior part such as liquid, bubble, and these parts can be controlled according to real-time status, and it is right
Analysis is judged with the performance level of operating process.
For liquid in micro-fluidic chip, its size, shape, speed, whether with the presence of bubble and inclusion concentration
Notable for final biochemical expression and assay influence etc. feature, so far, researcher is proposed based on various principles
Detection method, such as optical detection and the detection method based on capacitance sensing.
Optical detecting method mixes fluorescein in a liquid, using laser irradiating sample and reflexes to the photon meter of multichannel
Number device and photomultiplier, reach the average length and equispaced phase information of detection liquid.But fluorescence labeling is possible to draw
Play the analysis biochemical activity of material to change, influence is produced on result.What photomultiplier was detected is the average letter of liquid
Breath, it is impossible to liquid with precise control.Such method needs large-scale laboratory apparatus simultaneously, it is impossible in highly integrated micro-fluidic core
The real-time detection of multichannel is realized on piece.
And condenser type detection method depends on the capacitance variations that the change of different medium dielectric constant causes to realize to liquid
The real-time detection of body, it is to avoid various shortcomings of optical detecting method, but the capacitance variations very little caused due to liquid, its rear end
Detection circuit becomes relative complex, and the use of external power supply is also unfavorable for that it is supplying the use of occasion without power supply.
Therefore it provides the detection method of a kind of micro-fluidic middle liquid or bubble is a problem demanding prompt solution.
The content of the invention
The embodiment provides a kind of micro-fluidic liquid based on solid-liquid friction or bubble detection device and side
Method, to realize liquid and bubble in effectively detection micro-fluidic chip.
To achieve these goals, this invention takes following technical scheme.
A kind of micro-fluidic liquid or bubble detection device based on solid-liquid friction, including：Backing material, electrod-array,
Microfluidic channel in insulating hydrophobic material, microfluidic channel backing material and micro-fluidic chip；
The backing material, for supporting micro-fluidic chip；
The electrod-array, for positioned at the top of the backing material, for sensing solid-liquid triboelectrification；
The insulating hydrophobic material, for being electrified positioned at the top of the electrod-array, and fluid friction, and plays insulation
Effect；
The microfluidic channel, for positioned at the top of the insulating hydrophobic material, guiding liquid from the insulating hydrophobic
Flowed through on material；
The microfluidic channel backing material, for supporting the microfluidic channel.
Further, the electrod-array includes the conductive electrode of multiple comb teeth-shapeds, and each conductive electrode is interconnected, and
And arranged according to specified queueing discipline, forming array.
Further, the insulating polymer has same size with the cavity of the microfluidic channel.
Further, the backing material is the material for having certain degree of hardness；The material of the electrod-array is with certain
The material of conductive capability；The insulating hydrophobic material is have the material of certain hydrophobic ability or be attached on common insulating materials
Hydrophobic coating.
Further, the microfluidic channel is made up of the cavity that the microfluidic channel backing material is internally formed, micro-
Liquid, air and various reactants are flowed and are exchanged in the microfluidic channel in fluidic chip.
A kind of micro-fluidic liquid or bubble detecting method based on solid-liquid friction, are suitable for described based on solid-liquid friction
Micro-fluidic liquid or bubble detection device, including：
The micro-fluidic liquid based on solid-liquid friction or bubble detection device are arranged on the liquid of micro-fluidic chip
In passage；
It is upper from the electrod-array for being coated with insulating hydrophobic material liquid to be ordered about using the drive device in micro-fluidic chip
Cross；
The electric current at the electrod-array two ends is measured, and liquid in fluid channel is judged according to sense of current, size, frequency
Or direction, the velocity information of bubbly flow.
Further, the electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency
Judge the direction of liquid or bubbly flow, velocity information in fluid channel, including：
When in unidirectional flowing, single direction is only included in the individual signals sequence of the electrod-array two ends output
Current signal, it is determined that the liquid of bubbles does not flow on the electrod-array；And according to the electric current in the single direction
Signal is forward signal or reverse signal, judges the flow direction of the not liquid of bubbles.
Further, the electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency
Judge the direction of liquid or bubbly flow, velocity information in fluid channel, including：
After it is determined that the liquid of bubbles does not flow on the electrod-array, the electric current of the electrod-array two ends output
Flow rate of the amplitude proportional of signal in the liquid on the electrod-array.
Further, the electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency
Judge the direction of liquid or bubbly flow, velocity information in fluid channel, including：
After it is determined that the liquid of bubbles does not flow on the electrod-array, if single current signal is in the electrode array
The duration on counter electrode on row is t, and the electrode width of the counter electrode is w, and the liquid is in the electrode array
The computing formula of the flow rate v on row is as follows：
V=w/t.
Further, the electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency
Judge the direction of liquid or bubbly flow, velocity information in fluid channel, including：
When in unidirectional flowing, the individual signals sequence of the electrod-array two ends output include forward signal with
Reverse signal, it is determined that the liquid comprising bubble flows on the electrod-array.
The technical scheme provided by embodiments of the invention described above can be seen that the embodiment of the present invention and be rubbed using solid-liquid
Wiping raw electricity principle is used to detect the information such as liquid or bubbly flow, electrolyte concentration in fluid channel, without externally fed, structure
Simply, the advantages of preparation easy to process and existing micro-fluidic chip are easily integrated.By setting using array comb electrodes
Meter, is capable of detecting when the direction of liquid and difference and the liquid flowing of bubble, reaches the purpose that detection bubble is present；And according to
The time difference that liquid flows in Different electrodes part, the speed of liquid flowing is calculated, is finally reached the purpose of multi-functional detection,
And there is significant difference, it is easy to distinguish between unlike signal.
The additional aspect of the present invention and advantage will be set forth in part in the description, and these will become from the following description
Obtain substantially, or recognized by practice of the invention.
Brief description of the drawings
Technical scheme in order to illustrate more clearly the embodiments of the present invention, below will be to that will use needed for embodiment description
Accompanying drawing be briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for this
For the those of ordinary skill of field, without having to pay creative labor, other can also be obtained according to these accompanying drawings
Accompanying drawing.
Fig. 1 is the sectional view of the self-driven micro-fluidic liquid or bubble detection device rubbed based on solid-liquid.
Fig. 2 is to be regarded on the fluidic channel portion of the self-driven micro-fluidic liquid or bubble detecting method rubbed based on solid-liquid
Figure.
Fig. 3 is the hydrophobic material or electrode of the self-driven micro-fluidic liquid or bubble detecting method rubbed based on solid-liquid
Or substrate portions top view.
Fig. 4 is defeated when liquid is flowed on the self-driven micro-fluidic liquid or bubble detecting method rubbed based on solid-liquid
Go out electric signal waveform.
Fig. 5 is relation between the speed that liquid flows and output waveform.
Fig. 6 is output waveform when there is bubble in liquid.
Wherein, backing material 1, electrod-array 2, insulating hydrophobic material 3, microfluidic channel backing material 4 and micro-fluidic core
Microfluidic channel 5 in piece.
Specific embodiment
Embodiments of the present invention are described below in detail, the example of the implementation method is shown in the drawings, wherein ad initio
Same or similar element or element with same or like function are represented to same or similar label eventually.Below by ginseng
The implementation method for examining Description of Drawings is exemplary, is only used for explaining the present invention, and is not construed as limiting the claims.
Those skilled in the art of the present technique are appreciated that unless expressly stated, singulative " " used herein, " one
It is individual ", " described " and " being somebody's turn to do " may also comprise plural form.It is to be further understood that what is used in specification of the invention arranges
Diction " including " refer to exist the feature, integer, step, operation, element and or or component, but it is not excluded that in the presence of or add
Plus one or more other features, integer, step, operation, element, component and or or their group.It should be understood that working as us
Element is claimed to be " connected " or during " coupled " to another element, it can be directly connected or coupled to other elements, or can also
There is intermediary element.Additionally, " connection " used herein or " coupling " can include wireless connection or coupling.It is used herein to arrange
Diction " and or or " includes one or more associated any cells for listing item and all combines.
Those skilled in the art of the present technique are appreciated that unless otherwise defined, all terms used herein (including technology art
Language and scientific terminology) have with art of the present invention in those of ordinary skill general understanding identical meaning.Should also
Understand, those terms defined in such as general dictionary should be understood that the meaning having with the context of prior art
The consistent meaning of justice, and unless defined as here, will not be with idealizing or excessively formal implication be explained.
For ease of the understanding to the embodiment of the present invention, done by taking several specific embodiments as an example further below in conjunction with accompanying drawing
Explanation, and each embodiment does not constitute the restriction to the embodiment of the present invention.
The embodiment of the invention provides liquid and bubble in a kind of micro-fluidic chip of the self energizing based on solid-liquid friction
Detection method.The method have the advantages that simple structure, making easy to process and can large-scale integrated, and due to itself energy
Electric energy is enough exported, the design driven with detection circuit can be greatly simplified.Functionally, the method can realize liquid form,
The multi-functional detection of speed, electrolyte concentration, flow direction and bubble within fluid.
1- Fig. 3 illustrates the micro-fluidic liquid rubbed based on solid-liquid or the bubble detection of present invention offer below in conjunction with the accompanying drawings
The structure composition and application method of device.
Reference picture 1, Fig. 1 is that the embodiment of the invention provides a kind of micro-fluidic liquid based on solid-liquid friction or bubble inspection
The schematic cross-section of device is surveyed, its structure includes successively from the bottom to top：Backing material 1, electrod-array 2, insulating hydrophobic material 3,
Microfluidic channel 5 in microfluidic channel backing material 4 and micro-fluidic chip.The backing material, for supporting micro-fluidic core
Piece；
The electrod-array, for positioned at the top of the backing material, for sensing solid-liquid triboelectrification；Including multiple
The conductive electrode of comb teeth-shaped, each conductive electrode is interconnected, and is arranged according to specified queueing discipline, forming array.
The insulating hydrophobic material, for being electrified positioned at the top of the electrod-array, and fluid friction, and plays insulation
Effect；The insulating polymer has same size with the cavity of the microfluidic channel.
The microfluidic channel, for positioned at the top of the insulating hydrophobic material, guiding liquid from the insulating hydrophobic
Flowed through on material.
The microfluidic channel backing material, for supporting the microfluidic channel.
Fig. 2 is the fluidic channel portion top view in the device shown in Fig. 1, reference picture 2, in microfluidic channel backing material 4
Cavity composition microfluidic channel.
Fig. 3 be Fig. 1 shown in device in hydrophobic material or electrode or substrate portions top view, reference picture 3, absolutely
Edge polymer is located at the top of comb-like electrode, and has a same size with the cavity of fluid channel, comb-like electrode array it is mutual
Connection mode is as shown in Figure 3.
The backing material is material such as silica (SiO2), silicon (Si), the acrylic lucite for having certain degree of hardness
(PMMA), the material such as polytetrafluoroethylene (PTFE) (PTFE), paper.
The material of the electrod-array be with certain conductive capability material, including metal such as gold, copper, aluminium, with leading
The semi-conducting material of electric energy power such as indium and tin oxide film (indium tin oxide film, ITO), with conductive capability
Carbon-based material such as Graphene, CNT, graphite, carbon black etc., such as polymeric material with conductive capability, PEDOT:PSS etc.,
Electrod-array refers to that electrode is made up of at least one pair of array being arranged side by side.
The insulating hydrophobic material is the material for having certain hydrophobic ability, or is attached to the hydrophobic painting on common insulating materials
Layer, including fluorinated material such as Teflon (Teflon is also called polytetrafluoroethylene (PTFE)), silica gel material such as dimethyl silicone polymer
Fluorocarbon polymer and the micro- knot by Surface Machining that (Polydimethylsiloxane, PDMS), plasma deposition are produced
The hydrophobic material that structure is produced.Insulating hydrophobic material is located at the top of electrod-array, and plays insulation and sensing solid-liquid contact generation
Electric charge effect
The microfluidic channel backing material refers to the backing material for supporting fluid channel, and the material is general by poly dimethyl silicon
The materials such as oxygen alkane (Polydimethylsiloxane, PDMS), silica (SiO2), polytetrafluoroethylene (PTFE) (PTFE) and silicon (Si)
Material composition.
The microfluidic channel is that the cavity is usually by fid for the runner for allowing liquid to flow in micro-fluidic chip
Expect the cavity for being formed, for liquid, air, the flowing of various reactants in micro-fluidic chip and exchange.Microfluidic channel is located at
The top of the insulating hydrophobic material, play a part of guiding liquid flowing, and allow fluid to just from it is described for
Flowed through on the insulating hydrophobic material of fluid friction electrification.
The use process of micro-fluidic liquid or bubble detecting method based on solid-liquid friction provided in an embodiment of the present invention
Including following steps：
Step 1, by it is above-mentioned based on solid-liquid friction micro-fluidic liquid or bubble detection device be arranged on micro-fluidic chip
Fluid passage in；
Step 2, liquid is ordered about using the drive device in micro-fluidic chip from being coated with the electrode of insulating hydrophobic material
Flow through；
Step 3, the measurement at the same time entering array of row electrodes two ends electric current, and sentenced according to sense of current, size, frequency
Flowing is the information such as bubble or liquid and direction, speed and the electrolyte concentration of its flowing in disconnected fluid channel.
The operation principle of detection method proposed by the invention is：Based on the triboelectrification between solid and liquid, work as liquid
When being flowed on hydrophobic material, electric charge can be produced on hydrophobic material, due to the effect of electrostatic induction, on an array may be used
To induce electric charge, the rearrangement of the electric charge for thus causing, it is possible to current signal, electrolyte are formed between electrod-array
The difference of concentration can cause the change of output signal size, and the use of electrod-array can distinguish liquid flow direction, speed
Spend, whether contain the information such as bubble.
When in unidirectional flowing, single direction is only included in the individual signals sequence of the electrod-array two ends output
Current signal, it is determined that the liquid of bubbles does not flow on the electrod-array；And according to the electric current in the single direction
Signal is forward signal or reverse signal, judges the flow direction of the not liquid of bubbles.
After it is determined that the liquid of bubbles does not flow on the electrod-array, the electric current of the electrod-array two ends output
Flow rate of the amplitude proportional of signal in the liquid on the electrod-array.
After it is determined that the liquid of bubbles does not flow on the electrod-array, if single current signal is in the electrode array
The duration on counter electrode on row is t, and the electrode width of the counter electrode is w, and the liquid is in the electrode array
The computing formula of the flow rate v on row is as follows：
V=w/t.
When in unidirectional flowing, the individual signals sequence of the electrod-array two ends output include forward signal with
Reverse signal, it is determined that the liquid comprising bubble flows on the electrod-array.
Fig. 4 is a kind of liquid provided in an embodiment of the present invention in the self-driven micro-fluidic liquid or gas rubbed based on solid-liquid
Output electric signal waveform schematic diagram when being flowed in bubble detection method, when the liquid of not bubbles back and forth flows on the device
When, its output waveform is alternate positive negative signal, and in the unidirectional flowing of single, can only export the signal in single direction,
Such as forward current signal of flowing output to the right, the reverse current signal of flowing output to the left, such that it is able to according to current signal
Positive negative judgement liquid flow direction.
Fig. 5 is relation between the speed that a kind of liquid provided in an embodiment of the present invention flows and output waveform, can according to data
, output current amplitude increases and increases with liquid flow dynamic frequency, because liquid flow dynamic frequency is proportional to liquid flow rate, because
This can release flow rate according to current amplitude is counter；On the other hand, according to single current signal during lasting on counter electrode
Between t, this duration t and liquid is corresponding the time required to flowing through the electrode, can be measured by Wave data, and electrode width
W (this is given data), so that it may by formula v=w/t, is calculated the average speed that liquid flows on this electrode, similarly
The average speed on Different electrodes can be obtained.
Fig. 6 is output waveform when there is bubble in a kind of liquid provided in an embodiment of the present invention, during with the absence of bubble
One-way flow can only export one way signal difference, when there is bubble in liquid, reversely letter occur in individual signals sequence
Number, i.e., there is forward signal and reverse signal simultaneously.Now just can determine whether the presence of bubble.
In sum, the micro-fluidic liquid rubbed based on solid-liquid or bubble detection device of the embodiment of the present invention are by setting
Put：It is micro-fluidic logical in backing material, electrod-array, insulating hydrophobic material, microfluidic channel backing material and micro-fluidic chip
Road, with following beneficial effect：
1st, the present invention utilizes solid-liquid frictional electricity principle for detecting liquid or bubbly flow, electrolysis in fluid channel
The information such as matter concentration, are easily integrated etc. excellent without externally fed, simple structure, preparation easy to process and existing micro-fluidic chip
Point.
2nd, the design of the array comb electrodes that the present invention is used, is capable of detecting when the difference and liquid of liquid and bubble
The direction of flowing, reaches the purpose that detection bubble is present；And the time difference flowed in Different electrodes part according to liquid, calculate
The speed of liquid flowing, is finally reached the purpose of multi-functional detection, and has significant difference between unlike signal, it is easy to distinguish.
3rd, detection method proposed by the present invention has detection quick, and the optical detecting method compared to before can be realized whole
It is the miniaturization of individual detecting system, integrated.
One of ordinary skill in the art will appreciate that：Accompanying drawing is the schematic diagram of one embodiment, module in accompanying drawing or
Flow is not necessarily implemented necessary to the present invention.
One of ordinary skill in the art will appreciate that：The part in device in embodiment can be according to embodiment description point
It is distributed in the device of embodiment, it is also possible to carry out respective change and be disposed other than in one or more devices of the present embodiment.On
Stating the part of embodiment can merge into a part, it is also possible to be further split into multiple subassemblies.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any one skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
Should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with scope of the claims
It is defined.
Claims (10)
1. it is a kind of based on solid-liquid friction micro-fluidic liquid or bubble detection device, it is characterised in that including：Backing material,
Microfluidic channel in electrod-array, insulating hydrophobic material, microfluidic channel backing material and micro-fluidic chip；
The backing material, for supporting micro-fluidic chip；
The electrod-array, for positioned at the top of the backing material, for sensing solid-liquid triboelectrification；
The insulating hydrophobic material, makees for being electrified positioned at the top of the electrod-array, and fluid friction, and playing insulation
With；
The microfluidic channel, for positioned at the top of the insulating hydrophobic material, guiding liquid from the insulating hydrophobic material
On flow through；
The microfluidic channel backing material, for supporting the microfluidic channel.
2. device according to claim 1, it is characterised in that the electrod-array includes the conduction electricity of multiple comb teeth-shapeds
Pole, each conductive electrode is interconnected, and is arranged according to specified queueing discipline, forming array.
3. device according to claim 2, it is characterised in that the cavity of the insulating polymer and the microfluidic channel
With same size.
4. device according to claim 3, it is characterised in that the backing material is the material for having certain degree of hardness；It is described
The material of electrod-array is the material with certain conductive capability；The insulating hydrophobic material is the material for having certain hydrophobic ability
Or it is attached to the hydrophobic coating on common insulating materials.
5. device according to claim 4, it is characterised in that the microfluidic channel is by the microfluidic channel fid
The cavity that material is internally formed is constituted, and liquid, air and various reactants are carried out in the microfluidic channel in micro-fluidic chip
Flow and exchange.
6. a kind of micro-fluidic liquid or bubble detecting method based on solid-liquid friction, are suitable for any one of claim 1 to 5 institute
The micro-fluidic liquid rubbed based on solid-liquid or bubble detection device stated, it is characterised in that including：
The micro-fluidic liquid based on solid-liquid friction or bubble detection device are arranged on the fluid passage of micro-fluidic chip
In；
Liquid is ordered about using the drive device in micro-fluidic chip to flow through from being coated with the electrod-array of insulating hydrophobic material；
Measure the electric current at the electrod-array two ends, and according to sense of current, size, frequency judge in fluid channel liquid or
The direction of bubbly flow, velocity information.
7. it is according to claim 6 based on solid-liquid friction micro-fluidic liquid or bubble detecting method, it is characterised in that
The electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency judge in fluid channel liquid or
The direction of person's bubbly flow, velocity information, including：
When in unidirectional flowing, the electricity in single direction is only included in the individual signals sequence of the electrod-array two ends output
Stream signal, it is determined that the liquid of bubbles does not flow on the electrod-array；And according to the current signal in the single direction
It is forward signal or reverse signal, judges the flow direction of the not liquid of bubbles.
8. it is according to claim 7 based on solid-liquid friction micro-fluidic liquid or bubble detecting method, it is characterised in that
The electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency judge in fluid channel liquid or
The direction of person's bubbly flow, velocity information, including：
After it is determined that the liquid of bubbles does not flow on the electrod-array, the current signal of the electrod-array two ends output
Flow rate of the amplitude proportional in the liquid on the electrod-array.
9. it is according to claim 7 based on solid-liquid friction micro-fluidic liquid or bubble detecting method, it is characterised in that
The electric current at the described measurement electrod-array two ends, and according to sense of current, size, frequency judge in fluid channel liquid or
The direction of person's bubbly flow, velocity information, including：
After it is determined that the liquid of bubbles does not flow on the electrod-array, if single current signal is on the electrod-array
Counter electrode on duration be t, the electrode width of the counter electrode is w, and the liquid is on the electrod-array
Flow rate v computing formula it is as follows：
V=w/t.
10. micro-fluidic liquid or bubble detecting method based on solid-liquid friction according to claim 6, its feature exists
In described measures the electric current at the electrod-array two ends, and judges liquid in fluid channel according to sense of current, size, frequency
The direction of body or bubbly flow, velocity information, including：
When in unidirectional flowing, the individual signals sequence of the electrod-array two ends output includes forward signal and reverse
Signal, it is determined that the liquid comprising bubble flows on the electrod-array.
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