CN106691881A - Composition of solubilized phytosterol or ester, application of composition and cosmetic prepared from composition - Google Patents
Composition of solubilized phytosterol or ester, application of composition and cosmetic prepared from composition Download PDFInfo
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- CN106691881A CN106691881A CN201611078661.1A CN201611078661A CN106691881A CN 106691881 A CN106691881 A CN 106691881A CN 201611078661 A CN201611078661 A CN 201611078661A CN 106691881 A CN106691881 A CN 106691881A
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- Prior art keywords
- ester
- composition
- phytosterol
- alcohol
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- 150000002148 esters Chemical class 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 239000002537 cosmetic Substances 0.000 title claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 35
- 238000006116 polymerization reaction Methods 0.000 claims description 43
- -1 hexyl decyl Chemical group 0.000 claims description 37
- 229920001223 polyethylene glycol Polymers 0.000 claims description 37
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 26
- 239000003921 oil Substances 0.000 claims description 15
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 12
- 239000004359 castor oil Substances 0.000 claims description 12
- 235000019438 castor oil Nutrition 0.000 claims description 10
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 9
- 229930195729 fatty acid Natural products 0.000 claims description 9
- 239000000194 fatty acid Substances 0.000 claims description 9
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 4
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 claims description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 229960005082 etohexadiol Drugs 0.000 claims description 4
- 229940055577 oleyl alcohol Drugs 0.000 claims description 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 4
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000005456 glyceride group Chemical group 0.000 claims description 3
- OILXMJHPFNGGTO-NRHJOKMGSA-N Brassicasterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@](C)([C@H]([C@@H](/C=C/[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 OILXMJHPFNGGTO-NRHJOKMGSA-N 0.000 claims description 2
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 claims description 2
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 claims description 2
- OILXMJHPFNGGTO-ZRUUVFCLSA-N UNPD197407 Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)C=C[C@H](C)C(C)C)[C@@]1(C)CC2 OILXMJHPFNGGTO-ZRUUVFCLSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- OILXMJHPFNGGTO-ZAUYPBDWSA-N brassicasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@H](C)C(C)C)[C@@]1(C)CC2 OILXMJHPFNGGTO-ZAUYPBDWSA-N 0.000 claims description 2
- 235000004420 brassicasterol Nutrition 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 claims description 2
- 235000000431 campesterol Nutrition 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 229940113120 dipropylene glycol Drugs 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 2
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims description 2
- 229940051250 hexylene glycol Drugs 0.000 claims description 2
- 229940043348 myristyl alcohol Drugs 0.000 claims description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N n-decyl alcohol Natural products CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical class CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims description 2
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 claims description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 claims 1
- 235000016831 stigmasterol Nutrition 0.000 claims 1
- 229940032091 stigmasterol Drugs 0.000 claims 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 16
- 230000001815 facial effect Effects 0.000 abstract description 2
- 206010022998 Irritability Diseases 0.000 abstract 1
- 239000000686 essence Substances 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000001502 supplementing effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000009499 grossing Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003432 sterols Chemical group 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 1
- BQODPTQLXVVEJG-UHFFFAOYSA-N [O].C=C Chemical compound [O].C=C BQODPTQLXVVEJG-UHFFFAOYSA-N 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition of solubilized phytosterol or ester, application of the composition and a cosmetic prepared from the composition. The composition contains the components of phytosterol or ester thereof, higher alcohol, a low-polymerization-degree PEG-structured nonionic surfactant, a high-polymerization-degree PEG-structured nonionic surfactant and low alcohol in a weight ratio of 1 to (1-3) to (2-5) to (2-5) to (60-120). The prepared composition of solubilized phytosterol or ester thereof is applied to low-alcohol and alcohol-free water-based cosmetics such as lotions, essences and facial masks and is capable of promoting the dissolving of effective skin components such as phytosterol or ester in water, supplementing the oil content of the skin and increasing moist degree of the skin, the sticky feel of skin is low, and the irritability of the skin is low; and the composition is applicable to most aqueous systems, and the stability of the systems is not influenced.
Description
Technical field
The present invention relates to cosmetic field, the composition of more particularly to a kind of solubilized phytosterol or its ester and its application and
Cosmetics prepared therefrom.
Background technology
With the improvement of people ' s living standards, cosmetics have come into huge numbers of families, and people need to high-quality cosmetic
Ask increasingly serious.Due to needing, may require that some greases, active matter, essence, preservative are added in selection in water-based system sometimes
Deng oil soluble material.But, under general case, these lipophilic components are difficult to dissolve in formula system, it is impossible to form homogeneous.Cause
This, solubilizer just serves vital effect in this kind of cosmetics, and solubilizer can help lipophilic component to be dissolved in water
In, and form the homogeneous system of transparent and homogeneous.
In the market solubilizer composition is main based on nonionic surfactant and anion surfactant.By some
Nonpolar Low grease carries out solubilising, and generally requiring a large amount of HLB values nonionic table high and living carries out solubilising, but by phytosterol
Or the nonpolar grease high such as its ester solubilising in water, to transparent, be made the preparations such as toner and be difficult to, it is often adopted
With the nonionic surfactant of substantial amounts of high polymerization degree, but solution be also difficult to it is transparent, it is impossible to ensure that Cutaneous permeation absorbs.This
Outward, using the nonionic surfactant of a large amount of high polymerization degrees, glutinous soapy feeling and excitant can be caused to skin.
The content of the invention
For the shortcoming and deficiency that overcome prior art to exist, primary and foremost purpose of the invention is to provide a kind of solubilized plant
The composition of sterol or its ester, said composition is applied in water system cosmetics, can make solution solubilising to transparent, and the glutinous soapy feeling of skin
Low, excitant is small.
The present invention is achieved by the following technical solutions：
The composition of a kind of solubilized phytosterol or its ester, comprising component：Phytosterol or its ester, higher alcohol, oligomerization
Degree carries PEG structures nonionic surfactant and lower alcohol with PEG structures nonionic surfactant, high polymerization degree, its
In, phytosterol or its ester：Higher alcohol：Low polymerization degree carries PEG structure nonionic surfactants：High polymerization degree carries PEG
Structure nonionic surfactant：The weight ratio of lower alcohol is 1：1-3：2-5：2-5：60-120.
The present invention not selects tween according to HLB value, but by being conceived to the polarity of water, oil components
The technical method found with the PEG degree of polymerization of nonionic surfactant.Oil components are phytosterol or its ester, are non-pole
Property oil.However, the polarity highest of water, high polymerization degree is soluble in water with PEG structure nonionic surfactants, can not but be dissolved in
Oil.Low polymerization degree of the present invention by addition positioned at the rwo intermediate polarity carries PEG structures nonionic surfactant and height
Level alcohol, becomes both materials compatible.Additionally, being located at water and high polymerization degree with PEG structure nonionic tables plus polarity
Lower alcohol between the activating agent of face, make oil components in water can solubilising to transparent.From the point of view of the chemical constitution of higher alcohol, its alkane
The end of base carries hydroxyl, and polarity is high in oil components.Polarity bit of the low polymerization degree with PEG structure nonionic surfactants
Between the nonionic surfactant of higher alcohol and high polymerization degree with PEG structures, both are all solvable.The present invention is by research
Higher alcohol, low polymerization degree are lived with PEG structures nonionic surfactant, high polymerization degree with PEG structures non-ionic surface
Property agent and lower alcohol be combined with oil components, and the amount of each component is controlled in certain proportion, make its into
It is water and the intermediate polarity connectionist of oil components, can be by the small dispersion of oil components and solubilising to transparent.
According to phytosterol or its ester, higher alcohol, low polymerization degree with PEG structures nonionic surfactant, polymerization high
With the polar relationship between PEG structures nonionic surfactant and lower alcohol, it is 1 to select respective ratio to degree：1-3：2-5：
2-5：60-120.If low polymerization degree and high polymerization degree are very few with PEG structure nonionic surfactants, higher alcohol is excessive,
So polarity of the high polymerization degree with PEG structure nonionic surfactants but can not be soluble in the polarities match of water
It is so as to lamination occur or even muddy in higher alcohol.If low polymerization degree and high polymerization degree carry PEG structure nonionic tables
Face activating agent is excessive, and higher alcohol is very few, then polarity of the low polymerization degree with PEG structure nonionic surfactants can not and it is high
Level alcohol polarities match, also occurs corresponding layering, or even muddy.
Used as further preferred scheme of the invention, the composition of solubilized phytosterol of the present invention or its ester is planted
Thing sterol or its ester：Higher alcohol：Low polymerization degree carries PEG structure nonionic surfactants：High polymerization degree is non-with PEG structures
Ionic surface active agent：The weight ratio of lower alcohol is 1：2：3-4：3-4：80-100.
Wherein, the phytosterol or its ester are selected from phytosterol, phytosterol isostearate, cupreol, beans steroid
One or more in alcohol, campesterol, brassicasterol.
Wherein, the higher alcohol is in octyl dodecanol, isooctadecanol, myristyl alcohol, laruyl alcohol, hexyl decyl alcohol or oleyl alcohol
One or more, preferably octyl dodecanol, isooctadecanol or oleyl alcohol.
Wherein, the degree of polymerization of the high polymerization degree with PEG structure nonionic surfactants is 30-80, is chosen in particular from
Polyoxyethylene fatty glyceride type, polyoxyethylene hardened castor oil fatty acid ester type, polyoxyethylene hardened castor oil type, PCA are different
Stearate polyoxyethylene hardened castor oil type, polyoxyethylene fatty acid type, polyoxyethylene sorbitol type, polyoxyethylene alkyl ether
One or more in type, preferably one or more in Cremophor RH40 or PEG-60 rilanit specials.
Wherein, the degree of polymerization of the low polymerization degree with PEG structure nonionic surfactants is 6-20, is chosen in particular from gathering
Oxygen ethene fatty acid glycerine type, polyoxyethylene hardened castor oil fatty acid ester type, polyoxyethylene hardened castor oil type, PCA are different hard
Resin acid ester polyoxyethylene hardened castor oil type, polyoxyethylene fatty acid type, polyoxyethylene sorbitol type, polyoxyethylene alkyl ether-type
In one or more, preferably PEG-6 iso stearic acid of glycerine ester, PEG-8 iso stearic acid of glycerine ester, PEG-7 glyceryl cocoates
In one or more.
Wherein, the lower alcohol is one or more in C2-C9 alcohols, preferably glycerine, propane diols, butanediol, different
One or more in pentanediol, hexylene glycol, 1,2- pentanediols, ethohexadiol, ethohexadiol, dipropylene glycol or diglycerol.
The preparation method of the composition of the above-mentioned a kind of solubilized phytosterol of the present invention or its ester be by phytosterol or its
Ester, higher alcohol, low polymerization degree are lived with PEG structures nonionic surfactant, high polymerization degree with PEG structures non-ionic surface
Property agent and lower alcohol in proportion at 80 DEG C, dissolve it by stirring, reach solubilizing effect.
Composition present invention also offers above-mentioned solubilized phytosterol or its ester is in cosmetics, food or health products
Application.
Present invention also offers a kind of cosmetics, the composition comprising above-mentioned solubilized phytosterol or its ester.
Preferably, the addition of the composition of the solubilized phytosterol or its ester is the 5- of whole cosmetics gross mass
15%.
In the solubilized phytosterol of the invention described above or the composition of its ester, the scope of effect of the present invention is not being damaged
It is interior, can arbitrarily coordinate and generally may be fitted to the composition in cosmetics to prepare cosmetics.This any condition includes anti-corrosion
Agent, NMF, ultra-violet absorber, antioxidant, Ph conditioning agents etc..Its consumption is the conventional amount used for preparing cosmetics.
The present invention compared with prior art, has the advantages that：
(1) present invention carries PEG structures nonionic surfactant, high polymerization degree band by by higher alcohol, low polymerization degree
There are PEG structures nonionic surfactant and lower alcohol to be combined with oil components, and the amount of each component is controlled one
In fixed proportion, the solubilized phytosterol or the composition of its ester for preparing are applied to toner, Essence, facial mask
In etc. low alcohol, without alcohol aqua cosmetics, it is soluble in water to effectively facilitate the skin active ingredient such as phytosterol or its ester, can give
Skin supplement oil, the moist degree for increasing skin；
(2) the nonionic table containing PEG structures used in the composition of the solubilized phytosterol for preparing of the invention or its ester
Face activating agent consumption is few, and the glutinous soapy feeling of skin is low, excitant is small, it is adaptable to most of aqua system, and will not to system stability
Have an impact；
(3) preparation method of the present invention is simple to operate, easily realizes, prepared cosmetics cost performance is high, low cost.
Specific embodiment
The present invention is further illustrated below by specific embodiment, following examples are the present invention preferably embodiment party
Formula, but embodiments of the present invention are not limited by following embodiments.
Raw material of the present invention derives from commercial products.
Performance test methods：
The method of testing of appearance transparence stability：
Take transparent smoothing toner, be placed in 40 DEG C deposit 1 month, 25 DEG C of room temperature deposit 1 month, 5 DEG C of low temperature deposit 1 month, it is extensive
Answer and observe appearance transparence to room temperature.
The method of testing of the particle diameter of vitamin and its derivative：Tested using LS900 type laser particle size analyzers, surveyed
Examination scope：0.05~500 μm；Input mode：Wet method, circular sample feeder and static sample pond；Repeatability error：<3%；Test
Time：1-2 minutes；Standalone probe unit number：53；Light source category：Helium-neon laser, power：2.0mW, wavelength：0.6328μm；Work
Make environment：Temperature：5-35 DEG C, humidity：＜ 85%.
Light transmittance method of testing：Using ultraviolet-uisible spectrophotometer UV1000, Exposure Metering：Single beam；Wave-length coverage:
190.0~1100.0nm；Spectral bandwidth:2nm；Transmittance ranges:0~200%T；Range of absorbency:- 0.3~3Abs；Light source:
Deuterium lamp, halogen tungsten lamp；Dispersion element:Grating, 1200L/mm；Detector:Silicon photo diode；Use environment temperature:5 DEG C~35 DEG C；
Use environment relative humidity:≤ 85%.
The preparation of the composition of solubilized phytosterol or its ester：
It is formulated by table 1, phytosterol or phytosterol isostearate, higher alcohol, low polymerization degree is non-with PEG structures
Ionic surface active agent, high polymerization degree in proportion at 80 DEG C, pass through with PEG structures nonionic surfactant and lower alcohol
Stirring dissolves it, you can obtain solubilized phytosterol or the composition of its ester.
Table 1：The composition (weight portion) of the composition of solubilized phytosterol or its ester
Continued 1
Embodiment 1-13 and comparative example 1-5：
It is formulated by table 2, by the composition of solubilized phytosterol obtained above or its ester, preservative, pure water according to certain
Ratio at 40 DEG C, stirring is mixed with and obtains transparent smoothing toner, tests its performance, and results of property is as shown in table 2：
The composition and the performance test results (%) of the embodiment 1-13 of table 2 and the transparent smoothing toners of comparative example 1-5
Continued 2：
The present invention can be seen that by the result of the embodiment of table 2 and comparative example higher alcohol, low polymerization degree are carried into PEG structures
Nonionic surfactant, high polymerization degree are carried out with PEG structures nonionic surfactant and lower alcohol and oil components
Combination, and the amount of each component is controlled in certain proportion, the combination of the solubilized phytosterol or its ester that prepare
Thing, is applied in smoothing toner, and it is soluble in water to effectively facilitate the skin active ingredient such as phytosterol or its ester, can solubilising to saturating
It is bright.
Claims (10)
1. the composition of a kind of solubilized phytosterol or its ester, it is characterised in that comprising component：It is phytosterol or its ester, senior
Alcohol, low polymerization degree with PEG structures nonionic surfactant, high polymerization degree with PEG structures nonionic surfactant and
Lower alcohol, wherein, phytosterol or its ester：Higher alcohol：Low polymerization degree carries PEG structure nonionic surfactants：Height polymerization
Degree carries PEG structure nonionic surfactants：The weight ratio of lower alcohol is 1：1-3：2-5：2-5：60-120, preferably 1：1：
3-4：3-4：80-100.
2. the composition of solubilized phytosterol according to claim 1 or its ester, it is characterised in that the phytosterol or
Its ester is selected from phytosterol, phytosterol isostearate, cupreol, stigmasterol, campesterol and brassicasterol
Plant or several.
3. the composition of solubilized phytosterol according to claim 1 or its ester, it is characterised in that the higher alcohol is pungent
One or more in base lauryl alcohol, isooctadecanol, myristyl alcohol, laruyl alcohol, hexyl decyl alcohol or oleyl alcohol, preferably octyl group 12
One or more in alcohol, isooctadecanol or oleyl alcohol.
4. the composition of solubilized phytosterol according to claim 1 or its ester, it is characterised in that the high polymerization degree band
There is the degree of polymerization of PEG structure nonionic surfactants for 30-80, be chosen in particular from polyoxyethylene fatty glyceride type, polyoxy second
Alkene hardened castor oil fatty acid ester type, polyoxyethylene hardened castor oil type, PCA isostearate polyoxyethylene hardened castor oils
One or more in type, polyoxyethylene fatty acid type, polyoxyethylene sorbitol type, polyoxyethylene alkyl ether-type, preferably PEG-
One or more in 40 rilanit specials or PEG-60 rilanit specials.
5. the composition of solubilized phytosterol according to claim 1 or its ester, it is characterised in that the low polymerization degree band
There is the degree of polymerization of PEG structure nonionic surfactants for 6-20, be chosen in particular from polyoxyethylene fatty glyceride type, polyoxyethylene
Hardened castor oil fatty acid ester type, polyoxyethylene hardened castor oil type, PCA isostearate polyoxyethylene hardened castor oils type,
One or more in polyoxyethylene fatty acid type, polyoxyethylene sorbitol type, polyoxyethylene alkyl ether-type, preferably PEG-6 is sweet
One or more in oily isostearate, PEG-8 iso stearic acid of glycerine ester or PEG-7 glyceryl cocoates.
6. the composition of solubilized phytosterol according to claim 1 or its ester, it is characterised in that the lower alcohol is
One or more in C2-C9 alcohols.
7. the composition of solubilized phytosterol according to claim 6 or its ester, it is characterised in that the lower alcohol is sweet
Oil, propane diols, butanediol, isoprene, hexylene glycol, 1,2- pentanediols, ethohexadiol, ethohexadiol, dipropylene glycol or double sweet
One or more in oil.
8. solubilized phytosterol described in any one of claim 1-7 or the composition of its ester are in cosmetics, food or health products
In application.
9. a kind of cosmetics, comprising solubilized phytosterol or the composition of its ester described in claim any one of 1-8.
10. cosmetics according to claim 9, it is characterised in that the composition of the solubilized phytosterol or its ester
Addition is the 5-15% of whole cosmetics gross mass.
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