CN106674272A - Processing method for amifostine - Google Patents
Processing method for amifostine Download PDFInfo
- Publication number
- CN106674272A CN106674272A CN201611223892.7A CN201611223892A CN106674272A CN 106674272 A CN106674272 A CN 106674272A CN 201611223892 A CN201611223892 A CN 201611223892A CN 106674272 A CN106674272 A CN 106674272A
- Authority
- CN
- China
- Prior art keywords
- amifostine
- drier
- tank
- crystallizing tank
- processing method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 229960001097 amifostine Drugs 0.000 title claims abstract description 57
- 238000003672 processing method Methods 0.000 title claims abstract description 15
- 238000002425 crystallisation Methods 0.000 claims abstract description 21
- 230000008025 crystallization Effects 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 17
- 229910052782 aluminium Inorganic materials 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 16
- 230000007246 mechanism Effects 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 238000004090 dissolution Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000004411 aluminium Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000005096 rolling process Methods 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 239000013078 crystal Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000007599 discharging Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- YFYIWIZSIVZILB-UHFFFAOYSA-N N.[P] Chemical compound N.[P] YFYIWIZSIVZILB-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a processing method for amifostine. Through control of temperature and time parameters during crystallization, amifostine doesn't undergo other chemical reactions during crystallization, so that amifostine is high in crystallization efficiency. A single-cone vacuum dryer is arranged and can effectively purify and dry amifostine crystal to prepare an amifostine powder product.
Description
Technical field
The present invention relates to a kind of processing method for Amifostine.
Background technology
Amifostine in radiotherapy or chemotherapy process, is killing cancer as chemotherapy cytoprotection medicine and radiation therapy protective reagents
Normal tissue cell can be optionally protected during cell, patient is continuously received treatment.Kidney poison for releasing anticarcinogen,
The toxicities such as hemopoietic system, immunologic mjury that preventive radiotherapy causes have certain effect, are also used for reducing and neutrocyte
Reduce the related infection of disease.
Amifostine as cell-protecting, for chemotherapy to kidney, marrow, heart protection.
The existing processing to Amifostine, processing step is complex, and equipment is costly, relatively costly, and easily exists
Amifostine is chemically reacted during crystallization, cause the waste to Amifostine raw material, improve processing cost, and reduce ammonia phosphorus
The production and processing efficiency of spit of fland product.
The content of the invention
It is an object of the invention to provide a kind of processing method for Amifostine, step is simple, and processing efficiency is higher.
To reach above-mentioned purpose, the technical solution adopted by the present invention is：
A kind of processing method for Amifostine, comprises the following steps：
（1）Dissolution filter：1 part of Amifostine raw material is put into dissolving tank, and adds 1-3.5 parts of water, preheat the dissolving tank extremely
20-60 DEG C makes Amifostine dissolution of raw material, then adds the dissolving after 0.1-0.8 parts of water is mixed with 0.01-0.15 parts of activated carbon
In tank, 20-60 DEG C of temperature is kept, the mixture in the dissolving tank is stirred, the Amifostine raw material press filtration that will be dissolved
Into crystallizing tank；
（2）Crystallization：The crystallizing tank is heated to 20-60 DEG C, then to the second of 95% concentration that 0.1-10 parts is added dropwise in the crystallizing tank
Alcohol, keeps 20-60 DEG C of temperature, and 0.1-2.5h is stirred to the mixture in the crystallizing tank, then slow to the crystallizing tank
Slow cool down, makes the crystallizing tank that 0-15 DEG C is cooled in 2.5-6.5h, by obtained Amifostine crystallization press filtration to drier；
（3）Dry：The vavuum pump for vacuumizing is provided in the drier, is provided for taking out second in the drier bottom
The vacuum valve of alcohol, is provided for the rabbling mechanism of stirring in the drier, and portion is provided for week on the outside of the drier
The hot water circulating pump of heat drying；
First by the vavuum pump to being vacuumized inside the drier, secondly open the vacuum valve and extract ethanol, then
Open the rabbling mechanism to be stirred with the rotating speed of 5-35r/min, then start the hot water circulating pump with 20-55 DEG C of temperature
Degree dries 1-12h to the drier, finally closes the hot water circulating pump and the rabbling mechanism, takes out Amifostine finished product.
Preferably, in the step（1）In, will dissolve Amifostine raw material press filtration to the crystallizing tank in after, then
To water the cleaning activated carbon and the dissolving tank that 0.1-0.6 parts is added in the dissolving tank, the Amifostine raw material that will be remained
After dissolving in press filtration to the crystallizing tank.
Preferably, in the step（2）In, after obtained Amifostine is crystallized in press filtration to the drier, then
To the ethanol of 95% concentration that 0.1-0.5 parts is added in the crystallizing tank, after being cleaned to the inside of the crystallizing tank, then
In press filtration to the drier.
Preferably, in the step（2）In, the crystallizing tank is being cooled to 0-15 DEG C afterwards in 2.5-6.5h, make
The crystallizing tank maintains 0-15 DEG C, and continues 1-8h, then again by obtained Amifostine crystallization press filtration to the drier.
Preferably, in the step（3）In, the drier is single cone vacuum desiccator of the shape in back taper.
Preferably, in the step（3）Afterwards, Amifostine finished product is slowly fitted into sterile bag, the sterile bag is located at
In Aluminum Bottle, the Aluminum Bottle is weighed by weighing mechanism, when weight reaches setting value, tie the sterile bag, and cover
Upper aluminium lid.
It is highly preferred that the aluminium lid is tightened on the Aluminum Bottle by Cover-rolling machine.
Due to the utilization of above-mentioned technical proposal, the present invention has following advantages compared with prior art：A kind of use of the invention
In the processing method of Amifostine, by controlling temperature parameter and time parameter during crystallization, Amifostine is set not sent out in crystallization
Raw other chemical reactions, crystalline rate is high；By setting single cone vacuum desiccator, efficiently Amifostine crystallization can be carried
Pure drying, so that powdery Amifostine product is obtained.
Brief description of the drawings
Accompanying drawing 1 is the process chart of the inventive method.
Specific embodiment
The technical solution of the present invention will be further described below with reference to the accompanying drawings.
Shown in Figure 1, here is a kind of for Amifostine（C5H21N2O6PS）One of processing method specific implementation
Example, the method is comprised the following steps：
（1）Dissolution filter：The Amifostine raw material that quality is 1 part is put into dissolving tank, and to 2 parts of water are added in dissolving tank, in advance
The hot dissolving tank makes Amifostine dissolution of raw material in water to 40 DEG C, then after 0.5 part of water mix with 0.08 part of activated carbon addition this
In dissolving tank, dissolving tank is kept 40 DEG C of temperature, the mixture in dissolving tank is stirred, the Amifostine raw material that will be dissolved
In press filtration to crystallizing tank；After in Amifostine raw material press filtration to the crystallizing tank that will be dissolved, then to adding 0.3 part in dissolving tank
Inside water cleaning active charcoal and dissolving tank, after the Amifostine dissolution of raw material that will be remained also in press filtration to crystallizing tank；The step is molten
Carried out between solution, the clean rank between dissolving is C grades；
（2）Crystallization：Heating crystalline tank protects crystallizing tank to 50 DEG C, then to the ethanol of 95% concentration that 5 parts are added dropwise in the crystallizing tank
50 DEG C of temperature is held, 1.5h is stirred to the mixture in crystallizing tank, then to crystallizing tank Slow cooling, make crystallizing tank in 4.5h
Inside it is cooled to 0-15 DEG C；Crystallizing tank is being cooled to 0-15 DEG C afterwards in 4.5h, crystallizing tank is kept 0-15 DEG C of temperature, and
Continue 4.5h, then by obtained Amifostine crystallization press filtration to drier；Obtained Amifostine is being crystallized into press filtration to drying
After in device, then to the ethanol of 95% concentration that 0.3 part of normal temperature is added in crystallizing tank, the inside to crystallizing tank carries out cleaning
Afterwards, then by residue press filtration to drier；The step between crystallization in carry out, the clean rank between crystallization be A grades or B grades；
（3）Dry：The drier is single cone vacuum desiccator of the shape in back taper, is provided in singly cone vacuum desiccator
The vavuum pump for vacuumizing, is provided for taking out the vacuum valve of ethanol, in singly cone vacuum desiccator in singly cone vacuum desiccator bottom
The rabbling mechanism of stirring is provided for, portion is provided for the hot water circulating pump of heat drying week on the outside of singly cone vacuum desiccator；
First by vavuum pump to being vacuumized inside single cone vacuum desiccator, the vacuum valve for secondly opening bottom extracts waste ethanol,
Waste ethanol is drained net rear rabbling mechanism of opening to be stirred with the rotating speed of 20r/min, then starts hot water circulating pump with 35 DEG C
Temperature 6h is dried to single cone vacuum desiccator, finally close hot water circulating pump and rabbling mechanism, take out powdered Amifostine into
Product；The step between crystallization in carry out, the clean rank between crystallization be A grades or B grades；
（4）Discharging：It is provided for exporting the valve of powdered Amifostine finished product, turning for discharging in singly cone vacuum desiccator
Fortune bucket, the transferring barrel visor for observing transferring barrel state；
During discharging, slow Open valve observes material from transferring barrel visor, and valve is closed after bucket to be transported is full, unclamps docking, uses
It is aseptic change trains or buses by transferring barrel be transported to packing between dispense and weigh；The step between crystallization in carry out, the clean rank between crystallization be A
Level or B grades；
（5）Packing：Transferring barrel is docked with material guiding hopper valve, Aluminum Bottle is placed in the discharging opening of material guiding hopper valve, placed in Aluminum Bottle aseptic
Bag, powdered Amifostine finished product is slowly fitted into sterile bag, Aluminum Bottle is weighed by weighing mechanism, in the present embodiment
In, the weighing mechanism is electronic weighing balance, when the weight of Aluminum Bottle reaches setting value 10kg, ties sterile bag, and cover aluminium lid；
The step between packing in carry out, the clean rank between packing be A grades；
（6）Roll lid：Aluminium lid is tightened on Aluminum Bottle by Cover-rolling machine；The step is carried out in rolling between lid, rolls the clean level between lid
Wei A grades or B grades.
The above embodiments merely illustrate the technical concept and features of the present invention, its object is to allow person skilled in the art
Scholar will appreciate that present disclosure and be carried out that it is not intended to limit the scope of the present invention, all according to the present invention
The equivalent change or modification that Spirit Essence is made, should all cover within the scope of the present invention.
Claims (7)
1. a kind of processing method for Amifostine, it is characterised in that：Comprise the following steps：
（1）Dissolution filter：1 part of Amifostine raw material is put into dissolving tank, and adds 1-3.5 parts of water, preheat the dissolving tank extremely
20-60 DEG C makes Amifostine dissolution of raw material, then adds the dissolving after 0.1-0.8 parts of water is mixed with 0.01-0.15 parts of activated carbon
In tank, 20-60 DEG C of temperature is kept, the mixture in the dissolving tank is stirred, the Amifostine raw material press filtration that will be dissolved
Into crystallizing tank；
（2）Crystallization：The crystallizing tank is heated to 20-60 DEG C, then to the second of 95% concentration that 0.1-10 parts is added dropwise in the crystallizing tank
Alcohol, keeps 20-60 DEG C of temperature, and 0.1-2.5h is stirred to the mixture in the crystallizing tank, then slow to the crystallizing tank
Slow cool down, makes the crystallizing tank that 0-15 DEG C is cooled in 2.5-6.5h, by obtained Amifostine crystallization press filtration to drier；
（3）Dry：The vavuum pump for vacuumizing is provided in the drier, is provided for taking out second in the drier bottom
The vacuum valve of alcohol, is provided for the rabbling mechanism of stirring in the drier, and portion is provided for week on the outside of the drier
The hot water circulating pump of heat drying；
First by the vavuum pump to being vacuumized inside the drier, secondly open the vacuum valve and extract ethanol, then
Open the rabbling mechanism to be stirred with the rotating speed of 5-35r/min, then start the hot water circulating pump with 20-55 DEG C of temperature
Degree dries 1-12h to the drier, finally closes the hot water circulating pump and the rabbling mechanism, takes out Amifostine finished product.
2. a kind of processing method for Amifostine according to claim 1, it is characterised in that：In the step（1）In,
After in Amifostine raw material press filtration to the crystallizing tank that will be dissolved, then to adding 0.1-0.6 parts of water in the dissolving tank
The activated carbon and the dissolving tank are cleaned, after the Amifostine dissolution of raw material that will be remained in press filtration to the crystallizing tank.
3. a kind of processing method for Amifostine according to claim 1, it is characterised in that：In the step（2）In,
After obtained Amifostine is crystallized in press filtration to the drier, then to 95% of 0.1-0.5 parts of addition in the crystallizing tank
The ethanol of concentration, after being cleaned to the inside of the crystallizing tank, then in press filtration to the drier.
4. a kind of processing method for Amifostine according to claim 1, it is characterised in that：In the step（2）In,
The crystallizing tank is being cooled to 0-15 DEG C afterwards in 2.5-6.5h, the crystallizing tank is maintained 0-15 DEG C, and continue 1-
8h, then again by obtained Amifostine crystallization press filtration to the drier.
5. a kind of processing method for Amifostine according to claim 1, it is characterised in that：In the step（3）In,
The drier is single cone vacuum desiccator of the shape in back taper.
6. a kind of processing method for Amifostine according to claim 1, it is characterised in that：In the step（3）It
Afterwards, Amifostine finished product is slowly fitted into sterile bag, the sterile bag is entered by weighing mechanism in Aluminum Bottle to the Aluminum Bottle
Row is weighed, and when weight reaches setting value, ties the sterile bag, and cover aluminium lid.
7. a kind of processing method for Amifostine according to claim 6, it is characterised in that：Will be described by Cover-rolling machine
Aluminium lid is tightened on the Aluminum Bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223892.7A CN106674272A (en) | 2016-12-27 | 2016-12-27 | Processing method for amifostine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223892.7A CN106674272A (en) | 2016-12-27 | 2016-12-27 | Processing method for amifostine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106674272A true CN106674272A (en) | 2017-05-17 |
Family
ID=58871605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611223892.7A Pending CN106674272A (en) | 2016-12-27 | 2016-12-27 | Processing method for amifostine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106674272A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101412732A (en) * | 2008-09-02 | 2009-04-22 | 大连美罗药业股份有限公司 | Trihydrate 3-amino propyl amine ethyl phosphorothioic acid high purity stable crystal and preparation thereof |
| CN102260288A (en) * | 2010-06-08 | 2011-11-30 | 成都大有得药业有限公司 | Synthesis method of 3-amino-propyl aminoethyl thiophosphate trihydrate |
| CN102445058A (en) * | 2010-10-08 | 2012-05-09 | 沈善明 | Non-sealing single-cone vacuum dryer |
| CN103509046A (en) * | 2013-07-22 | 2014-01-15 | 衡阳师范学院 | Bis(tri(2-methyl-2-phenyl propyl)tin) dicarboxylic ester and preparation method and application thereof |
| CN103727753A (en) * | 2012-10-12 | 2014-04-16 | 沈善明 | Wedge-shaped plate internal heating pyramid vacuum dryer |
-
2016
- 2016-12-27 CN CN201611223892.7A patent/CN106674272A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101412732A (en) * | 2008-09-02 | 2009-04-22 | 大连美罗药业股份有限公司 | Trihydrate 3-amino propyl amine ethyl phosphorothioic acid high purity stable crystal and preparation thereof |
| CN102260288A (en) * | 2010-06-08 | 2011-11-30 | 成都大有得药业有限公司 | Synthesis method of 3-amino-propyl aminoethyl thiophosphate trihydrate |
| CN102445058A (en) * | 2010-10-08 | 2012-05-09 | 沈善明 | Non-sealing single-cone vacuum dryer |
| CN103727753A (en) * | 2012-10-12 | 2014-04-16 | 沈善明 | Wedge-shaped plate internal heating pyramid vacuum dryer |
| CN103509046A (en) * | 2013-07-22 | 2014-01-15 | 衡阳师范学院 | Bis(tri(2-methyl-2-phenyl propyl)tin) dicarboxylic ester and preparation method and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 沈善明: "介绍小型无密封单锥药品真空干燥机", 《医药工程设计》 * |
| 沈善明: "热敏性药品的干燥", 《医药工程设计》 * |
| 沈善明等: "提高中药粉粒体蒸汽灭菌的效率和节能探讨", 《医药工程设计》 * |
| 沈善明等: "用作特殊性物料干燥的单锥真空干燥机", 《医药工程设计》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170517 |
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| RJ01 | Rejection of invention patent application after publication |