CN213347840U - Lopinavir intermediate crystallization device - Google Patents
Lopinavir intermediate crystallization device Download PDFInfo
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- CN213347840U CN213347840U CN202021635790.8U CN202021635790U CN213347840U CN 213347840 U CN213347840 U CN 213347840U CN 202021635790 U CN202021635790 U CN 202021635790U CN 213347840 U CN213347840 U CN 213347840U
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Abstract
The utility model discloses a lopinavir midbody crystallization device, the power distribution box comprises a box body, fixedly connected with disc in the middle of the box top, disc top front end rear side through connection has the inlet pipe, through connection has the rotation post in the middle of the disc top, the rotation post top is rotated and is connected with the rotation motor, fixedly connected with reation kettle in the middle of the inside roof of box, through connection has first discharging pipe in the middle of the reation kettle bottom, first discharging pipe front side bottom fixedly connected with second discharging pipe, the outside fixedly connected with condenser pipe of second discharging pipe. The utility model discloses an oily liquid gives reation kettle heating to oily liquid parcel reation kettle can accomplish for reation kettle even heating, prevents that local heating from producing and be unfavorable for the crystallization, and the worker can also avoid user direct contact reaction solution through the particular case of high temperature resistant glass observation box internal heating simultaneously.
Description
Technical Field
The utility model mainly relates to lopinavir makes technical field, concretely relates to lopinavir midbody crystallization device.
Background
Lopinavir is an HIV-1 box HIV-2 protease inhibitor, can be combined with low-dose ritonavir, can improve the pharmacokinetics characteristics of the lopinavir, is approved by the United states food and drug administration to be on the market in 2000 by lopinavir and low-dose ritonavir composite tablets, has reliable curative effect, low side effect and small food influence, and plays an important role in antiviral treatment of HIV patients who fail to initially treat drug resistance.
The method is also extremely important for producing lopinavir intermediate which is an important raw material for producing lopinavir, when the lopinavir intermediate is obtained by using a combination reaction, the lopinavir intermediate in a solution needs to be crystallized and precipitated, the existing crystallization equipment is too simple, the crystallization effect is not obvious, the solution and the crystal need to be artificially taken out after crystallization, the process is very complicated, and workers are possibly injured.
SUMMERY OF THE UTILITY MODEL
The utility model mainly provides a lopinavir midbody crystallization device for solve the technical problem who provides among the above-mentioned background art.
The utility model provides a technical scheme that above-mentioned technical problem adopted does:
a lopinavir intermediate crystallization device comprises a box body, wherein high-temperature glass is fixedly connected in the middle of the top of the front end of the box body through a groove, a water pump is fixedly connected in the rear of the bottom of the front end of the box body, a water outlet pipe is fixedly connected in the middle of the front end of the water pump and penetrates through the front wall of the box body, a water inlet pipe is connected in the rear of the top of the front side of the box body and penetrates through the inner wall of the box body, a disc is fixedly connected in the middle of the top of the box body, an inlet pipe is connected in the rear of the front end of the top of the disc and penetrates through the inner wall of the box body, a rotating column is connected in the middle of the top of the disc and rotatably connected with a rotating motor, a reaction kettle is fixedly connected in the middle of the inner wall of the box body, the rotating, the middle of reation kettle bottom through connection has first discharging pipe, first discharging pipe front side bottom fixedly connected with second discharging pipe, the outside fixedly connected with condenser pipe of second discharging pipe, condenser pipe rear side fixedly connected with outlet pipe, condenser pipe front side fixedly connected with inlet tube, the one end contact that first discharging pipe was kept away from to the second discharging pipe is connected with material receiving box, the fixedly connected with filter screen in the middle of the inside four walls of material receiving box, fixedly connected with temperature-sensing ware in the middle of the inside diapire rear end of box, fixedly connected with heating machine in the middle of the inside diapire front end of box.
The temperature sensor is connected with a heater through a lead, and sealant is coated at the joint of the high-temperature-resistant glass and the box body.
The oil-based liquid is filled in the box body, a rubber belt is fixedly mounted on the inner wall of the box body, a rubber belt is fixedly mounted on the outer portion of the reaction kettle, and a rubber belt is fixedly mounted on the outer portion of the heater.
The filter screen material is the microporous membrane filter core, the filter screen is equipped with drying device, the inlet pipe top can be sealed.
The condenser pipe communicates the outlet pipe, the condenser pipe communicates the inlet tube, high temperature resistant glass adopts double-deck design, and the centre is the vacuum.
The water pump is connected with a power supply device through a wire, and the rotating motor is connected with the power supply device through a wire.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model adopts the oily liquid to heat the reaction kettle, and the oily liquid wraps the reaction kettle, can uniformly heat the reaction kettle, after the reaction kettle is heated, the solvent in the lopinavir intermediate solution can be volatilized, so that the concentration of the lopinavir intermediate is improved, meanwhile, workers can observe the specific condition of heating in the box body through the high-temperature resistant glass, the process is favorably carried out, meanwhile, after the heating, the concentration of the lopinavir intermediate is promoted, after a locking device of a first discharging pipe is opened, the lopinavir intermediate solution automatically enters a second discharging pipe and is cooled through a condensing pipe, the condensing pipe adopts a lower inlet and outlet principle, the temperature of the lopinavir intermediate solution can be rapidly reduced, crystals are separated out, then the filtering is carried out on a filter screen, the required lopinavir intermediate fine product is obtained by drying, the novel use does not need the direct contact of the user with the lopinavir intermediate solution, reducing the harm to the user.
The present invention will be explained in detail with reference to the drawings and specific embodiments.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the cross-sectional structure of the present invention;
fig. 3 is the schematic view of the sectional structure of the reaction kettle of the present invention.
In the figure: 1. a feed pipe; 2. a disc; 3. high temperature resistant glass; 4. a box body; 5. a water pump; 6. a water outlet conduit; 7. a water inlet pipe; 8. rotating the motor; 9. a water inlet conduit; 10. a condenser tube; 11. a second discharge pipe; 12. a material receiving box; 13. a filter screen; 14. a temperature sensor; 15. a reaction kettle; 16. a heater; 17. rotating the rod; 18. rotating the column; 19. a first discharge pipe; 20. and (5) discharging a water pipe.
Detailed Description
In order to facilitate understanding of the present invention, the present invention will be described more fully with reference to the accompanying drawings, in which several embodiments of the present invention are shown, but the present invention can be implemented in different forms, and is not limited to the embodiments described in the text, but rather, these embodiments are provided to make the disclosure of the present invention more thorough and comprehensive.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may be present, and when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, as the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the use of the term knowledge in the specification of the present invention is for the purpose of describing particular embodiments and is not intended to limit the present invention, and the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Please refer to fig. 1-3 heavily, a lopinavir intermediate crystallization device comprises a box 4, a high temperature resistant glass 3 is fixedly connected to the middle of the top of the front end of the box 4 through a groove, a water pump 5 is fixedly connected to the rear side of the bottom of the front end of the box 4, a water outlet pipe 6 is fixedly connected to the middle of the front end of the water pump 5, the water outlet pipe 6 penetrates through the front wall of the box 4, a water inlet pipe 9 is connected to the rear end of the top of the front side of the box 4, the water inlet pipe 9 penetrates through the inner wall of the box 4, a disc 2 is fixedly connected to the middle of the top of the box 4, a feeding pipe 1 is connected to the rear side of the front end of the top of the disc 2, the feeding pipe 1 penetrates through the top wall of the box 4, a rotating column 18 is connected to the middle of the top of the disc 2, a, rotate post 18 bottom through connection and have a plurality of rotating rod 17, through connection has first discharging pipe 19 in the middle of the 15 bottom of reation kettle, first discharging pipe 19 front side bottom fixedly connected with second discharging pipe 11, the outside fixedly connected with condenser pipe 10 of second discharging pipe 11, condenser pipe 10 rear side fixedly connected with outlet pipe 20, condenser pipe 10 front side fixedly connected with inlet tube 7, the one end contact that first discharging pipe 19 was kept away from to second discharging pipe 11 is connected with material receiving box 12, fixedly connected with filter screen 13 in the middle of the inside four walls of material receiving box 12, fixedly connected with temperature-sensing ware 14 in the middle of the inside diapire rear end of box 4, fixedly connected with heating machine 16 in the middle of the inside diapire front end of box 4.
The temperature sensor 14 is connected with a heater 16 through a wire, the heater 16 is controlled by the temperature sensor 14, when the temperature does not meet the requirement, the automatic heating process is realized, and the joint of the high-temperature-resistant glass 3 and the box body 4 is coated with sealant, so that the whole box body is sealed, and the temperature is prevented from being leaked.
The inside packing of box 4 has oily class liquid, and oily class liquid fixed mounting has the heating block, can realize the even heating to the time of temperature maintenance is long, and 4 inner wall fixed mounting of box have the rubber band, and reation kettle 15 external fixed mounting has the rubber band, and 16 external fixed mounting of heater has the rubber band, can prevent that oily class liquid from corroding internal arrangement, protects internal arrangement, makes whole device life longer. The filter screen 13 material is the microporous membrane filter core, and filter screen 13 is equipped with drying device, and inlet pipe 1 top can be sealed, and filterable guide lopinavir midbody essence can be to lopinavir midbody essence heating simultaneously.
The utility model discloses a concrete operation as follows:
when the user uses the novel water tank, the oily liquid is injected into the tank body 4 by the water inlet conduit 9, then the water inlet conduit 9 is closed, then the user pours the lopinavir intermediate liquid obtained after the reaction into the reaction kettle 15 by using the feed pipe 1, then the user starts the rotating motor 8 to start the stirring of the reaction kettle 15, and simultaneously starts the heating machine 16 to uniformly heat the reaction kettle 15 by the water bath heating method and fully stir, and the user observes the heating condition in front of the high temperature resistant glass 3, and the temperature sensor 14 monitors the temperature of the oily liquid in real time, when the temperature reaches a certain value, the temperature sensor 14 will cut off the power supply to the heater 16, customize the heating, then the user opens the first discharge pipe 19 blocking device to start discharging, and simultaneously cold water is added into the condensation pipe 10 to cool the solution, and finally the user obtains lopinavir intermediate fine products on the filter screen 13.
The present invention has been described above with reference to the accompanying drawings, and it is obvious that the present invention is not limited by the above-mentioned manner, if the method and the technical solution of the present invention are adopted, the present invention can be directly applied to other occasions without substantial improvement, and the present invention is within the protection scope of the present invention.
Claims (6)
1. The utility model provides a lopinavir midbody crystallization device, includes box (4), its characterized in that: the middle of the top of the front end of the box body (4) is fixedly connected with high-temperature-resistant glass (3) through a groove, the rear side of the bottom of the front end of the box body (4) is fixedly connected with a water pump (5), the middle of the front end of the water pump (5) is fixedly connected with a water outlet pipe (6), the water outlet pipe (6) penetrates through the front wall of the box body (4), the rear end of the top of the front side of the box body (4) is connected with a water inlet pipe (9) in a penetrating manner, the water inlet pipe (9) penetrates through the inner wall of the box body (4), the middle of the top of the box body (4) is fixedly connected with a disc (2), the rear side of the front end of the top of the disc (2) is connected with a feeding pipe (1) in a penetrating manner, the feeding pipe (1) penetrates through the inner top wall of the box, fixedly connected with reation kettle (15) in the middle of the inside roof of box (4), rotate post (18) and run through the inside roof of reation kettle (15), it has a plurality of rotating rods (17) to rotate post (18) bottom through connection, first discharging pipe (19) is run through connected in the middle of reation kettle (15) bottom, first discharging pipe (19) front side bottom fixedly connected with second discharging pipe (11), second discharging pipe (11) outside fixedly connected with condenser pipe (10), condenser pipe (10) rear side fixedly connected with outlet pipe (20), condenser pipe (10) front side fixedly connected with inlet tube (7), the one end contact that first discharging pipe (19) was kept away from in second discharging pipe (11) is connected with material receiving box (12), fixedly connected with filter screen (13) in the middle of the inside four walls of material receiving box (12), fixedly connected with temperature-sensing ware (14) in the middle of the inside diapire rear end of box (4), and a heater (16) is fixedly connected in the middle of the front end of the bottom wall in the box body (4).
2. The lopinavir intermediate crystallization device of claim 1, wherein: the temperature-sensing ware (14) are connected with heater (16) through the wire, high temperature resistant glass (3) scribble sealed glue with box (4) junction, first discharging pipe (19) fixed mounting has the blocking device.
3. The lopinavir intermediate crystallization device of claim 1, wherein: the oil-based liquid is filled in the box body (4), a rubber belt is fixedly mounted on the inner wall of the box body (4), the rubber belt is fixedly mounted on the outer portion of the reaction kettle (15), and the rubber belt is fixedly mounted on the outer portion of the heater (16).
4. The lopinavir intermediate crystallization device of claim 1, wherein: filter screen (13) material is the micropore membrane filter core, filter screen (13) are equipped with drying device, inlet pipe (1) top can be sealed.
5. The lopinavir intermediate crystallization device of claim 1, wherein: condenser pipe (10) intercommunication outlet pipe (20), condenser pipe (10) intercommunication inlet tube (7), high temperature resistant glass (3) adopt the double-deck design, and the centre is the vacuum.
6. The lopinavir intermediate crystallization device of claim 1, wherein: the water pump (5) is connected with a power supply device through a wire, and the rotating motor (8) is connected with the power supply device through a wire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021635790.8U CN213347840U (en) | 2020-08-10 | 2020-08-10 | Lopinavir intermediate crystallization device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021635790.8U CN213347840U (en) | 2020-08-10 | 2020-08-10 | Lopinavir intermediate crystallization device |
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| CN213347840U true CN213347840U (en) | 2021-06-04 |
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| CN202021635790.8U Active CN213347840U (en) | 2020-08-10 | 2020-08-10 | Lopinavir intermediate crystallization device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274758A (en) * | 2021-06-24 | 2021-08-20 | 温州市金榜轻工机械有限公司 | Crystallizing tank for crystallizing cannabidiol in industrial hemp |
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2020
- 2020-08-10 CN CN202021635790.8U patent/CN213347840U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274758A (en) * | 2021-06-24 | 2021-08-20 | 温州市金榜轻工机械有限公司 | Crystallizing tank for crystallizing cannabidiol in industrial hemp |
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