CN106634704A - Anti-allergic medical pressure-sensitive adhesive and preparation process thereof - Google Patents
Anti-allergic medical pressure-sensitive adhesive and preparation process thereof Download PDFInfo
- Publication number
- CN106634704A CN106634704A CN201611118873.8A CN201611118873A CN106634704A CN 106634704 A CN106634704 A CN 106634704A CN 201611118873 A CN201611118873 A CN 201611118873A CN 106634704 A CN106634704 A CN 106634704A
- Authority
- CN
- China
- Prior art keywords
- parts
- sensitive adhesive
- medical pressure
- pressure sensitive
- antiallergy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000004820 Pressure-sensitive adhesive Substances 0.000 title claims abstract description 37
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims abstract description 29
- 239000004014 plasticizer Substances 0.000 claims abstract description 24
- 239000003999 initiator Substances 0.000 claims abstract description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 20
- -1 buckwheat-flavonoids Polymers 0.000 claims abstract description 20
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims abstract description 18
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002510 mandelic acid Drugs 0.000 claims abstract description 18
- LVGFPWDANALGOY-UHFFFAOYSA-N 8-methylnonyl prop-2-enoate Chemical compound CC(C)CCCCCCCOC(=O)C=C LVGFPWDANALGOY-UHFFFAOYSA-N 0.000 claims abstract description 17
- IIDNACBMUWTYIV-VIFPVBQESA-N benzyl (2s)-2-amino-3-hydroxypropanoate Chemical compound OC[C@H](N)C(=O)OCC1=CC=CC=C1 IIDNACBMUWTYIV-VIFPVBQESA-N 0.000 claims abstract description 17
- 229920002367 Polyisobutene Polymers 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 11
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940041616 menthol Drugs 0.000 claims abstract description 11
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 10
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 190000012306 pyrithione zinc Chemical compound 0.000 claims abstract description 10
- 229960001141 pyrithione zinc Drugs 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 229940046009 vitamin E Drugs 0.000 claims abstract description 10
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 10
- 239000011709 vitamin E Substances 0.000 claims abstract description 10
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims abstract description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 17
- 229920001651 Cyanoacrylate Polymers 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- 229920000459 Nitrile rubber Polymers 0.000 claims description 14
- 241000219051 Fagopyrum Species 0.000 claims description 10
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims description 10
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 10
- 229930003944 flavone Natural products 0.000 claims description 10
- 150000002212 flavone derivatives Chemical class 0.000 claims description 10
- 235000011949 flavones Nutrition 0.000 claims description 10
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 10
- 244000144730 Amygdalus persica Species 0.000 claims description 9
- 238000010792 warming Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- CWXZAJNUTOBAOI-UHFFFAOYSA-N 1-(2,3-dimethoxyphenyl)-2-hydroxy-2-phenylethanone Chemical compound COC1=CC=CC(C(=O)C(O)C=2C=CC=CC=2)=C1OC CWXZAJNUTOBAOI-UHFFFAOYSA-N 0.000 claims description 4
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims description 4
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 241000220324 Pyrus Species 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- XSMJZKTTXZAXHD-UHFFFAOYSA-N ethene;2-methylprop-2-enoic acid Chemical group C=C.CC(=C)C(O)=O XSMJZKTTXZAXHD-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 235000021017 pears Nutrition 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 abstract description 5
- 230000000172 allergic effect Effects 0.000 abstract description 4
- 208000010668 atopic eczema Diseases 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 229920001971 elastomer Polymers 0.000 abstract description 3
- 239000005060 rubber Substances 0.000 abstract description 3
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 abstract 1
- 240000006413 Prunus persica var. persica Species 0.000 abstract 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical class C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 abstract 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 abstract 1
- AZIQALWHRUQPHV-UHFFFAOYSA-N prop-2-eneperoxoic acid Chemical compound OOC(=O)C=C AZIQALWHRUQPHV-UHFFFAOYSA-N 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 7
- 229920000136 polysorbate Polymers 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003292 glue Substances 0.000 description 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- 150000008363 butyronitriles Chemical class 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229920006264 polyurethane film Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
- C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J123/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C09J123/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
- C09J123/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/08—Macromolecular additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J2301/00—Additional features of adhesives in the form of films or foils
- C09J2301/30—Additional features of adhesives in the form of films or foils characterized by the chemical, physicochemical or physical properties of the adhesive or the carrier
- C09J2301/302—Additional features of adhesives in the form of films or foils characterized by the chemical, physicochemical or physical properties of the adhesive or the carrier the adhesive being pressure-sensitive, i.e. tacky at temperatures inferior to 30°C
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses an anti-allergic medical pressure-sensitive adhesive and a preparation process thereof. The pressure-sensitive adhesive is prepared from the following raw materials: polyisobutene, isodecyl acrylate, acrylate-hydroxy ester, glycidyl methacrylate, alpha-cyanoacrylate, dithiothreitol, buckwheat-flavonoids, Tween 80, pyrithione zinc, L-serine benzyl ester, hydrogenated butadiene-acrylonitrile rubber, mandelic acid, menthol, peach gum, hydroxypropyl-beta-cyclodextrin, vitamin E, an initiator and plasticiser. The medical pressure-sensitive adhesive prepared by the invention presents a higher moisture-vapor transmission rate and moderate viscosity, can be used for repeatedly removing a label for more than 5 times, is flexible to use, has good compatibility with the skin, and has no stimulation to the skin and no allergic phenomenon, the experience effect of a patient is better, and the applied range is wide.
Description
Technical field
The invention belongs to medical material tech field, and in particular to a kind of antiallergy medical pressure sensitive adhesive and its preparation technology.
Background technology
Pressure sensitive adhesive be used to needing in the various applications being adhered on skin, such as medical adhesive tape, wound or surgical dressing, use
In the thick and heavy dressing of apparatus or comparison such as remaining needle, ductus venosus are fixed on skin yet with the flat of skin surface
Whole degree and hair, secretion, cuticular presence, surface property, the mechanical property of skin especially dynamic mechanical with
The difference of other materials is bigger, makes pressure sensitive adhesive increasingly complex with the bond properties problem of skin.Generally for increase pressure sensitive adhesive with
The cementitiousness of skin, reduces alice and obscission, and some tackifier are often added in pressure sensitive adhesive, but some are viscosified
The membership that adds of agent causes allergic, and in addition the breathable moisture permeability of conventional pressure sensitive adhesive is not good, is unfavorable for skin perspiration.Therefore,
In order to obtain more preferable using effect and range of application, need pressure sensitive adhesive to have preferable compatibility with skin, possess sufficiently high
Steam penetrability and gentle viscosity, and can repeatedly take off patch and use.
The content of the invention
For this purpose, the present invention provides a kind of antiallergy medical pressure sensitive adhesive and its preparation technology, solve at least one in prior art
Plant technical problem.
For this purpose, the present invention provides a kind of antiallergy medical pressure sensitive adhesive, it is prepared by the raw material of following weight portion：Poly- isobutyl
Alkene 34-45 parts, isodecyl acrylate 12-22 parts, crylic acid hydroxy ester 6-15 parts, GMA 3-9 parts, a-
Cyanoacrylate 2-5 parts, dithiothreitol (DTT) 1-6 parts, buckwheat flavone 2-5 parts, Tween 80 1-3 parts, pyrithione zinc 1-4 parts, L-
Serine benzyl ester 2-6 part, hydrogenated nitrile-butadiene rubber 5-9 parts, mandelic acid 2-7 parts, menthol 3-6 parts, peach gum 5-12 parts, hydroxypropyl-
Beta-schardinger dextrin 4-8 parts, vitamin E 1.2-3 parts, initiator 0.6-1.8 parts, plasticizer 1.4-2.2 parts.
An embodiment of the invention, wherein, the initiator is benzoyl peroxide or tetramethylethylenediamine
Or dimethoxybenzoin.
An embodiment of the invention, wherein, the plasticizer is glycerine, sorbierite, mannose or poly- second two
Alcohol.
An embodiment of the invention, wherein, it is prepared by the raw material of following weight portion：Polyisobutene 36-
43 parts, isodecyl acrylate 14-21 parts, crylic acid hydroxy ester 7.5-13 parts, GMA 3.5-8 parts, a-
Cyanoacrylate 2.4-4.6 parts, dithiothreitol (DTT) 1.2-5.6 parts, buckwheat flavone 2.4-4.5 parts, Tween 80 1.4-2.5 parts,
Pyrithione zinc 1.8-3.2 parts, Serine benzyl ester 2.7-5 part, hydrogenated nitrile-butadiene rubber 5.2-7.5 parts, mandelic acid 2.4-6.3 parts,
Menthol 3.4-5.8 parts, peach gum 5.5-10 parts, HP-β-CD 4.2-7.6 parts, vitamin E 1.5-2.8 parts, initiation
Agent 0.8-1.5 parts, plasticizer 1.6-2.1 parts.
For this purpose, the present invention provides a kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then at 110-140 DEG C
At a temperature of banburying 4-10 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 7-15 minutes at a temperature of 110-140 DEG C；
Step 3）Room temperature is cooled to, is crushed standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 160-190 DEG C is first heated to, 20- is stirred
40min, is subsequently adding initiator, plasticizer and step 3）In crushed material, 190-230 DEG C is warming up to, in 500-1000r/min
Rotating speed under stir 15-30min；
Step 5）Remaining material is added, at 150-180 DEG C, to stir 1-3 hours under the rotating speed of 200-800r/min, is cooled to
Room temperature, you can.
An embodiment of the invention, wherein, the step 1）In at a temperature of 120 DEG C banburying 6 minutes；It is described
Step 2）In at a temperature of 135 DEG C banburying 12 minutes.
An embodiment of the invention, wherein, the step 3）In be crushed to 200-400 mesh.
An embodiment of the invention, wherein, the step 4）It is middle to be first heated to 175 DEG C, stir 35min；Institute
State step 4）In be warming up to 210 DEG C, stir 25min under the rotating speed of 800r/min.
An embodiment of the invention, wherein, the step 5）At 165 DEG C, with the rotating speed of 500r/min
Stirring 3 hours.
Beneficial effects of the present invention are：
The peel strength of medical pressure sensitive adhesive prepared by the present invention at 25 DEG C reaches 11.8-13.4N, and moisture transmission is 604-634
g/m2/ 24h, the higher moisture transmission of display and gentle viscosity, and the number of times that can be noticed repeatedly is more than 5 times, uses flexibly,
It is good with the compatibility of skin, it is non-stimulated to skin and without allergic phenomena, Patient Experience effect preferably, applied range.
Specific embodiment
With reference to embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention, but not
For limiting the scope of the present invention.
Embodiment 1
A kind of antiallergy medical pressure sensitive adhesive, is prepared by the raw material of following weight portion：34 parts of polyisobutene, isodecyl acrylate
12 parts, 6 parts of crylic acid hydroxy ester, 3 parts of GMA, 2 parts of a- cyanoacrylates, 1 part of dithiothreitol (DTT),
2 parts of buckwheat flavone, 1 part of Tween 80,1 part of pyrithione zinc, 2 parts of Serine benzyl ester, 5 parts of hydrogenated nitrile-butadiene rubber, 2 parts of mandelic acid,
3 parts of menthol, 5 parts of peach gum, 4 parts of HP-β-CD, 1.2 parts of vitamin E, 0.6 part of initiator, 1.4 parts of plasticizer.
Wherein, the initiator is benzoyl peroxide.
Wherein, the plasticizer is glycerine.
A kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then in 110 DEG C of temperature
Lower banburying 4 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 7 minutes at a temperature of 140 DEG C；
Step 3）Room temperature is cooled to, 200-400 mesh is crushed to, it is standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 160 DEG C are first heated to, 20min is stirred,
It is subsequently adding initiator, plasticizer and step 3）In crushed material, be warming up to 190 DEG C, under the rotating speed of 500r/min stir
15min；
Step 5）Remaining material is added, at 150 DEG C, to stir 1 hour under the rotating speed of 200r/min, room temperature is cooled to, you can.
Embodiment 2
A kind of antiallergy medical pressure sensitive adhesive, is prepared by the raw material of following weight portion：45 parts of polyisobutene, isodecyl acrylate
22 parts, 15 parts of crylic acid hydroxy ester, GMA 3-9 parts, 5 parts of a- cyanoacrylates, dithiothreitol (DTT) 6
Part, 5 parts of buckwheat flavone, 3 parts of Tween 80,4 parts of pyrithione zinc, 6 parts of Serine benzyl ester, 9 parts of hydrogenated nitrile-butadiene rubber, mandelic acid 7
Part, 6 parts of menthol, 12 parts of peach gum, 8 parts of HP-β-CD, 3 parts of vitamin E, 1.8 parts of initiator, 2.2 parts of plasticizer.
Wherein, the initiator is tetramethylethylenediamine.
Wherein, the plasticizer is sorbierite.
A kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then in 140 DEG C of temperature
Lower banburying 10 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 7 minutes at a temperature of 140 DEG C；
Step 3）Room temperature is cooled to, 200-400 mesh is crushed to, it is standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 190 DEG C are first heated to, 40min is stirred,
It is subsequently adding initiator, plasticizer and step 3）In crushed material, be warming up to 230 DEG C, under the rotating speed of 1000r/min stir
30min；
Step 5）Remaining material is added, at 180 DEG C, to stir 3 hours under the rotating speed of 800r/min, room temperature is cooled to, you can.
Embodiment 3
A kind of antiallergy medical pressure sensitive adhesive, is prepared by the raw material of following weight portion：36 parts of polyisobutene, isodecyl acrylate
14 parts, 7.5 parts of crylic acid hydroxy ester, 3.5 parts of GMA, 2.4 parts of a- cyanoacrylates, two sulphur threoses
1.2 parts of alcohol, 2.4 parts of buckwheat flavone, 1.4 parts of Tween 80,1.8 parts of pyrithione zinc, 2.7 parts of Serine benzyl ester, hydrogenated butyronitrile rubber
5.2 parts of glue, 2.4 parts of mandelic acid, 3.4 parts of menthol, 5.5 parts of peach gum, 4.2 parts of HP-β-CD, 1.5 parts of vitamin E,
0.8 part of initiator, 1.6 parts of plasticizer.
Wherein, the initiator is dimethoxybenzoin.
Wherein, the plasticizer is mannose.
A kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then in 120 DEG C of temperature
Lower banburying 8 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 10 minutes at a temperature of 135 DEG C；
Step 3）Room temperature is cooled to, 200-400 mesh is crushed to, it is standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 175 DEG C are first heated to, 35min is stirred,
It is subsequently adding initiator, plasticizer and step 3）In crushed material, be warming up to 210 DEG C, under the rotating speed of 700r/min stir
20min；
Step 5）Remaining material is added, at 170 DEG C, to stir 2 hours under the rotating speed of 650r/min, room temperature is cooled to, you can.
Embodiment 4
A kind of antiallergy medical pressure sensitive adhesive, is prepared by the raw material of following weight portion：43 parts of polyisobutene, isodecyl acrylate
21 parts, 13 parts of crylic acid hydroxy ester, 8 parts of GMA, 4.6 parts of a- cyanoacrylates, dithiothreitol (DTT)
5.6 parts, 4.5 parts of buckwheat flavone, 2.5 parts of Tween 80,3.2 parts of pyrithione zinc, 5 parts of Serine benzyl ester, hydrogenated nitrile-butadiene rubber
7.5 parts, 6.3 parts of mandelic acid, 5.8 parts of menthol, 10 parts of peach gum, 7.6 parts of HP-β-CD, 2.8 parts of vitamin E, draw
Send out 1.5 parts of agent, 2.1 parts of plasticizer.
Wherein, the initiator is tetramethylethylenediamine.
Wherein, the plasticizer is polyethylene glycol.
A kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then in 130 DEG C of temperature
Lower banburying 5 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 14 minutes at a temperature of 120 DEG C；
Step 3）Room temperature is cooled to, 200-400 mesh is crushed to, it is standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 185 DEG C are first heated to, 35min is stirred,
It is subsequently adding initiator, plasticizer and step 3）In crushed material, be warming up to 210 DEG C, under the rotating speed of 800r/min stir
20min；
Step 5）Remaining material is added, at 170 DEG C, to stir 3 hours under the rotating speed of 550r/min, room temperature is cooled to, you can.
Embodiment 5
A kind of antiallergy medical pressure sensitive adhesive, is prepared by the raw material of following weight portion：40 parts of polyisobutene, isodecyl acrylate
18 parts, 10.2 parts of crylic acid hydroxy ester, 5.7 parts of GMA, 3.5 parts of a- cyanoacrylates, two sulphur Soviet Union
3.4 parts of sugar alcohol, 3.5 parts of buckwheat flavone, 2 parts of Tween 80,2.5 parts of pyrithione zinc, 3.8 parts of Serine benzyl ester, hydrogenated butyronitrile rubber
6.3 parts of glue, 4.1 parts of mandelic acid, 4 parts of menthol, 7.5 parts of peach gum, 5.8 parts of HP-β-CD, 2 parts of vitamin E, initiation
1.1 parts of agent, 1.8 parts of plasticizer.
Wherein, the initiator is dimethoxybenzoin.
Wherein, the plasticizer is mannose.
A kind of preparation technology of antiallergy medical pressure sensitive adhesive, including following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then in 120 DEG C of temperature
Lower banburying 6 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 12 minutes at a temperature of 135 DEG C；
Step 3）Room temperature is cooled to, 200-400 mesh is crushed to, it is standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 175 DEG C are first heated to, 35min is stirred,
It is subsequently adding initiator, plasticizer and step 3）In crushed material, be warming up to 210 DEG C, under the rotating speed of 800r/min stir
25min；
Step 5）Remaining material is added, at 165 DEG C, to stir 3 hours under the rotating speed of 500r/min, room temperature is cooled to, you can.
Comparative example 1
It is in place of this comparative example and the difference of embodiment 1：Not comprising a- cyanoacrylates, buckwheat flavone and menthol.
Comparative example 2
It is in place of this comparative example and the difference of embodiment 1：Not comprising vitamin E, mandelic acid and Serine benzyl ester.
To the pressure-sensitive adhesives prepared by above example and comparative example on polyurethane film, dry glue thickness is 25 micro-
Rice, tests its gas permeability at 25 DEG C, is then affixed to test its peel strength on skin, and observes its service condition, its test
As a result it is as shown in the table：
| Numbering | Peel strength/N | Moisture transmission/g/m2/24h | Whether sensitization | Skin irritation index | Patch number of times can repeatedly be taken off |
| Embodiment 1 | 11.8 | 604 | It is no | 0 | 5-6 |
| Embodiment 2 | 12.3 | 616 | It is no | 0 | 4-5 |
| Embodiment 3 | 12.9 | 623 | It is no | 0 | 5-6 |
| Embodiment 4 | 13.1 | 628 | It is no | 0 | 6-7 |
| Embodiment 5 | 13.4 | 634 | It is no | 0 | 6-7 |
| Comparative example 1 | 9.6 | 577 | It is no | 0 | 2-3 |
| Comparative example 2 | 8.9 | 583 | Slightly | 0 | 3-4 |
Test from more than, the peel strength of medical pressure sensitive adhesive prepared by the present invention at 25 DEG C reaches 11.8-13.4N, moisture
Transmitance is 604-634 g/m2/ 24h, the higher moisture transmission of display and gentle viscosity, and the number of times that can be noticed repeatedly
It is good with the compatibility of skin using flexible more than 5 times, it is non-stimulated to skin and without allergic phenomena, Patient Experience effect preferably,
Applied range.
Claims (9)
1. a kind of antiallergy medical pressure sensitive adhesive, it is characterised in that be prepared by the raw material of following weight portion：Polyisobutene 34-
45 parts, isodecyl acrylate 12-22 parts, crylic acid hydroxy ester 6-15 parts, GMA 3-9 parts, a- cyano group
Acrylate 2-5 parts, dithiothreitol (DTT) 1-6 parts, buckwheat flavone 2-5 parts, Tween 80 1-3 parts, pyrithione zinc 1-4 parts, L- silk ammonia
Acid benzyl ester 2-6 parts, hydrogenated nitrile-butadiene rubber 5-9 parts, mandelic acid 2-7 parts, menthol 3-6 parts, peach gum 5-12 parts, hydroxy propyl-Beta-ring
Dextrin 4-8 parts, vitamin E 1.2-3 parts, initiator 0.6-1.8 parts, plasticizer 1.4-2.2 parts.
2. a kind of antiallergy medical pressure sensitive adhesive according to claim 1, it is characterised in that the initiator is benzoyl peroxide
Formyl or tetramethylethylenediamine or dimethoxybenzoin.
3. a kind of antiallergy medical pressure sensitive adhesive according to claim 1, it is characterised in that the plasticizer is glycerine, mountain
Pears alcohol, mannose or polyethylene glycol.
4. a kind of antiallergy medical pressure sensitive adhesive according to claim 1, it is characterised in that by the raw material of following weight portion
It is prepared：Polyisobutene 36-43 parts, isodecyl acrylate 14-21 parts, crylic acid hydroxy ester 7.5-13 parts, methacrylic acid
Ethylene oxidic ester 3.5-8 parts, a- cyanoacrylate 2.4-4.6 parts, dithiothreitol (DTT) 1.2-5.6 parts, buckwheat flavone 2.4-4.5
Part, Tween 80 1.4-2.5 parts, pyrithione zinc 1.8-3.2 parts, Serine benzyl ester 2.7-5 part, hydrogenated nitrile-butadiene rubber 5.2-7.5
Part, mandelic acid 2.4-6.3 parts, menthol 3.4-5.8 parts, peach gum 5.5-10 parts, HP-β-CD 4.2-7.6 parts, dimension life
Plain E 1.5-2.8 parts, initiator 0.8-1.5 parts, plasticizer 1.6-2.1 parts.
5. according to a kind of preparation technology of the arbitrary described antiallergy medical pressure sensitive adhesive of claim 1-4, it is characterised in that include
Following preparation process：
Step 1）Hydrogenated nitrile-butadiene rubber, Serine benzyl ester and a- cyanoacrylates are well mixed, then at 110-140 DEG C
At a temperature of banburying 4-10 minutes；
Step 2）Isodecyl acrylate, crylic acid hydroxy ester and GMA are added, is well mixed, Ran Hou
Banburying 7-15 minutes at a temperature of 110-140 DEG C；
Step 3）Room temperature is cooled to, is crushed standby；
Step 4）Polyisobutene, dithiothreitol (DTT) and mandelic acid are added in reactor, 160-190 DEG C is first heated to, 20- is stirred
40min, is subsequently adding initiator, plasticizer and step 3）In crushed material, 190-230 DEG C is warming up to, in 500-1000r/min
Rotating speed under stir 15-30min；
Step 5）Remaining material is added, at 150-180 DEG C, to stir 1-3 hours under the rotating speed of 200-800r/min, is cooled to
Room temperature, you can.
6. a kind of preparation technology of antiallergy medical pressure sensitive adhesive according to claim 5, it is characterised in that the step 1）
In at a temperature of 120 DEG C banburying 6 minutes；The step 2）In at a temperature of 135 DEG C banburying 12 minutes.
7. a kind of preparation technology of antiallergy medical pressure sensitive adhesive according to claim 5, it is characterised in that the step 3）
In be crushed to 200-400 mesh.
8. a kind of preparation technology of antiallergy medical pressure sensitive adhesive according to claim 5, it is characterised in that the step 4）
It is middle to be first heated to 175 DEG C, stir 35min；The step 4）In be warming up to 210 DEG C, under the rotating speed of 800r/min stir
25min。
9. a kind of preparation technology of antiallergy medical pressure sensitive adhesive according to claim 5, it is characterised in that the step 5）
At 165 DEG C, to stir 3 hours under the rotating speed of 500r/min.
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